-
Erratum. Inhibition of motility by NEO100 through the calpain-1/RhoA pathway. J Neurosurg. 2024 Nov 29; 1-2.
Chen TC, Marín-Ramos NI. PMID: 39612493.
View in:
PubMed Mentions: Fields:
-
In Reply: Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model. Neurosurgery. 2025 Feb 01; 96(2):e34.
Chen TC, Schönthal AH. PMID: 39812481.
View in:
PubMed Mentions: Fields:
-
Characterization of cerebrospinal fluid markers as indicators of spinal cord ischemia following an endovascular aortic aneurysm repair procedure. J Neurosurg. 2024 Nov 01; 1-10.
Danilov CA, Yu JYH, Gong M, Han SM, Fleischman F, Magee GA, Weaver F, Schönthal AH, Chen TC. PMID: 39486078.
View in:
PubMed Mentions: Fields:
-
Automated patient selection and care coaches to increase advance care planning for cancer patients. J Natl Cancer Inst. 2024 Sep 30.
Gensheimer MF, Teuteberg W, Patel MI, Gupta D, Noroozi M, Ling X, Fardeen T, Seevaratnam B, Lu Y, Alves N, Rogers B, Asuncion MK, Denofrio J, Hansen J, Shah NH, Chen T, Cabebe E, Blayney DW, Colevas AD, Ramchandran K. PMID: 39348179.
View in:
PubMed Mentions: Fields:
-
Application and Safety of Externally Controlled Metronomic Drug Delivery to the Brain by an Implantable Smart Pump in a Sheep Model. Neurosurgery. 2024 Sep 06.
Chen TC, Wu WH, Chang KE, Schönthal AH, Gang ES, Indravudh V, Lobl T, Adell F, Shachar Y. PMID: 39240099; PMCID: PMC11698269.
View in:
PubMed Mentions: Fields:
-
Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage. Photochem Photobiol. 2024 Jul 05.
Swenson S, Silva-Hirschberg C, Freeland L, Chen KL, Marín-Ramos NI, Schönthal AH, Chen TC. PMID: 38970228.
View in:
PubMed Mentions: Fields:
-
NEO212, temozolomide conjugated to NEO100, exerts superior therapeutic activity over temozolomide in preclinical chemoradiation models of glioblastoma. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae095.
Minea RO, Thein TZ, Yang Z, Campan M, Ward PM, Schönthal AH, Chen TC. PMID: 39022643; PMCID: PMC11252566.
View in:
PubMed Mentions:
-
MicroRNA-133b Dysregulation in a Mouse Model of Cervical Contusion Injury. Int J Mol Sci. 2024 Mar 06; 25(5).
Yu JYH, Chen TC, Danilov CA. PMID: 38474302; PMCID: PMC10931801.
View in:
PubMed Mentions: Fields:
Translation:
Animals
-
Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide. Cancers (Basel). 2024 Feb 26; 16(5).
Hartman-Houstman H, Swenson S, Minea RO, Sinha UK, Chiang MF, Chen TC, Schönthal AH. PMID: 38473298; PMCID: PMC10931041.
View in:
PubMed Mentions:
-
Enhancing brain entry and therapeutic activity of chimeric antigen receptor T cells with intra-arterial NEO100 in a mouse model of CNS lymphoma. J Neurosurg. 2024 Jun 01; 140(6):1549-1557.
Wang W, He H, Zheng L, Zeng S, Cho HY, Kouhi A, Khawli LA, Chen L, Stathopoulos A, Schönthal AH, Epstein AL, Chen TC. PMID: 38157532.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
-
Reduced non-CpG methylation is a potential epigenetic target after spinal cord injury. Neural Regen Res. 2023 Nov; 18(11):2489-2496.
Wu Z, Li C, Zhu R, Cao Y, Chen TC, Cheng L. PMID: 37282481; PMCID: PMC10360082.
View in:
PubMed Mentions:
1
-
A cross-sectional study to test equivalence of low- versus intermediate-flip angle dynamic susceptibility contrast MRI measures of relative cerebral blood volume in patients with high-grade gliomas at 1.5 Tesla field strength. Front Oncol. 2023; 13:1156843.
Shiroishi MS, Weinert D, Cen SY, Varghese B, Dondlinger T, Prah M, Mendoza J, Nazemi S, Ameli N, Amini N, Shohas S, Chen S, Bigjahan B, Zada G, Chen T, Neman-Ebrahim J, Chang EL, Chow FE, Fan Z, Yang W, Attenello FJ, Ye J, Kim PE, Patel VN, Lerner A, Acharya J, Hu LS, Quarles CC, Boxerman JL, Wu O, Schmainda KM. PMID: 37799462; PMCID: PMC10548232.
View in:
PubMed Mentions:
3
-
Using machine learning and big data for the prediction of venous thromboembolic events after spine surgery: A single-center retrospective analysis of multiple models on a cohort of 6869 patients. J Craniovertebr Junction Spine. 2023 Jul-Sep; 14(3):221-229.
Hopkins BS, Cloney MB, Dhillon ES, Texakalidis P, Dallas J, Nguyen VN, Ordon M, Tecle NE, Chen TC, Hsieh PC, Liu JC, Koski TR, Dahdaleh NS. PMID: 37860027; PMCID: PMC10583792.
View in:
PubMed Mentions:
1
-
Inhibition of autophagy and induction of glioblastoma cell death by NEO214, a perillyl alcohol-rolipram conjugate. Autophagy. 2023 12; 19(12):3169-3188.
Ou M, Cho HY, Fu J, Thein TZ, Wang W, Swenson SD, Minea RO, Stathopoulos A, Schönthal AH, Hofman FM, Tang L, Chen TC. PMID: 37545052; PMCID: PMC10621246.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
From the groin to the brain: a transfemoral path to blood-brain barrier opening. Oncotarget. 2023 05 04; 14:413-416.
Chen TC, Wang W, Schönthal AH. PMID: 37141417; PMCID: PMC10159364.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Intranasal Delivery of miR133b in a NEO100-Based Formulation Induces a Healing Response in Spinal Cord-Injured Mice. Cells. 2023 03 18; 12(6).
Danilov CA, Thein TZ, Tahara SM, Schönthal AH, Chen TC. PMID: 36980272; PMCID: PMC10047048.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
-
Enhanced brain entry of checkpoint-inhibitory therapeutic antibodies facilitated by intraarterial NEO100 in mouse models of brain-localized malignancies. J Neurosurg. 2023 09 01; 139(3):822-830.
Wang W, He H, Zeng S, Cho HY, Minea RO, Swenson SD, Zheng L, Epstein AL, Stathopoulos A, Chen L, Schönthal AH, Chen TC. PMID: 36738464.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
NEO212, a Perillyl Alcohol-Temozolomide Conjugate, Triggers Macrophage Differentiation of Acute Myeloid Leukemia Cells and Blocks Their Tumorigenicity. Cancers (Basel). 2022 Dec 09; 14(24).
Chen TC, Minea RO, Swenson S, Yang Z, Thein TZ, Schönthal AH. PMID: 36551551; PMCID: PMC9776529.
View in:
PubMed Mentions:
3
-
Detection of perillyl alcohol and its metabolite perillic acid in postsurgical glioblastoma tissue after intranasal administration of NEO100: illustrative case. J Neurosurg Case Lessons. 2022 Aug 22; 4(8).
Schönthal AH, Swenson S, Bonney PA, Wagle N, Simmon VF, Mathew AJ, Hurth KM, Chen TC. PMID: 36088606; PMCID: PMC9706323.
View in:
PubMed Mentions:
3
-
A Prospective, Cohort Study of SITOIGANAP to Treat Glioblastoma When Given in Combination With Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Nivolumab or Granulocyte-Macrophage Colony-Stimulating Factor/Cyclophosphamide/Bevacizumab/Pembrolizumab in Patients Who Failed Prior Treatment With Surgical Resection, Radiation, and Temozolomide. Front Oncol. 2022; 12:934638.
Bota DA, Taylor TH, Lomeli N, Kong XT, Fu BD, Schönthal AH, Singer S, Blumenthal DT, Senecal FM, Linardou H, Rokas E, Antoniou DG, Schijns VEJC, Chen TC, Elliot J, Stathopoulos A. PMID: 35837107; PMCID: PMC9273968.
View in:
PubMed Mentions:
2
-
5-Aminolevulinic acid-enhanced fluorescence-guided treatment of high-grade glioma using angled endoscopic blue light visualization: technical case series with preliminary follow-up. J Neurosurg. 2022 Nov 01; 137(5):1378-1386.
Strickland BA, Wedemeyer M, Ruzevick J, Micko A, Shahrestani S, Daneshmand S, Shiroishi MS, Hwang DH, Attenello F, Chen T, Zada G. PMID: 35303704.
View in:
PubMed Mentions:
4 Fields:
-
Lumbar surgical drains do not increase the risk of infections in patients undergoing spine surgery. Eur Spine J. 2022 07; 31(7):1775-1783.
Buser Z, Chang KE, Kall R, Formanek B, Arakelyan A, Pak S, Schafer B, Liu JC, Wang JC, Hsieh P, Chen TC. PMID: 35147769.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers. Pharmaceutics. 2021 Dec 16; 13(12).
Chen TC, da Fonseca CO, Levin D, Schönthal AH. PMID: 34959448; PMCID: PMC8709132.
View in:
PubMed Mentions:
12
-
Corrigendum to: Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer. Neuro Oncol. 2021 Dec 01; 23(12):2123.
Wang W, He H, Marín-Ramos NI, Zeng S, Swenson SD, Cho HY, Fu J, Beringer PM, Neman J, Chen L, Schönthal AH, Chen TC. PMID: 34519783; PMCID: PMC8643429.
View in:
PubMed Mentions: Fields:
-
Surviving Over a Decade With Glioblastoma: A Clinical Course Characterized by Multiple Recurrences, Numerous Salvage Treatments, and Novel Use of Cesium-131 Tiles. Cureus. 2021 Nov; 13(11):e19573.
Mehta S, Vassantachart AK, Fossum CC, Yang W, Shen ZL, Chang KE, Ye JC, Chen TC, Chang EL. PMID: 34926045; PMCID: PMC8671070.
View in:
PubMed Mentions:
2
-
Enhanced brain delivery and therapeutic activity of trastuzumab after blood-brain barrier opening by NEO100 in mouse models of brain-metastatic breast cancer. Neuro Oncol. 2021 10 01; 23(10):1656-1667.
Wang W, He H, Marín-Ramos NI, Zeng S, Swenson SD, Cho HY, Fu J, Beringer PM, Neman J, Chen L, Schönthal AH, Chen TC. PMID: 33659980; PMCID: PMC8485439.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 Jul 27; 36(4):109475.
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34320362.
View in:
PubMed Mentions:
3 Fields:
-
Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia. Cancers (Basel). 2021 Jul 06; 13(14).
Schönthal AH, Swenson S, Minea RO, Kim HN, Cho H, Mohseni N, Kim YM, Chen TC. PMID: 34298603; PMCID: PMC8305595.
View in:
PubMed Mentions:
2
-
Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination. Cell Rep. 2021 06 29; 35(13):109302.
Martirosian V, Deshpande K, Zhou H, Shen K, Smith K, Northcott P, Lin M, Stepanosyan V, Das D, Remsik J, Isakov D, Boire A, De Feyter H, Hurth K, Li S, Wiemels J, Wiemels J, Nakamura B, Shao L, Danilov C, Chen T, Neman J. PMID: 34192534; PMCID: PMC8848833.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory. Curr Protoc. 2021 Jun; 1(6):e140.
Martirosian V, Deshpande K, Lin M, Jarvis C, Yuan E, Chen TC, Zada G, Giannotta SL, Attenello FJ, Chow F, Neman J. PMID: 34170630; PMCID: PMC8869842.
View in:
PubMed Mentions:
3 Fields:
Translation:
Humans
-
In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models. J Neurosci Res. 2021 09; 99(9):2029-2045.
Attenello FJ, Tsung K, Bishara I, Loh YE, Chen TC. PMID: 33969526.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
Phase I trial of intranasal NEO100, highly purified perillyl alcohol, in adult patients with recurrent glioblastoma. Neurooncol Adv. 2021 Jan-Dec; 3(1):vdab005.
Schönthal AH, Peereboom DM, Wagle N, Lai R, Mathew AJ, Hurth KM, Simmon VF, Howard SP, Taylor LP, Chow F, da Fonseca CO, Chen TC. PMID: 33604574; PMCID: PMC7879254.
View in:
PubMed Mentions:
11
-
NEO100 enables brain delivery of blood‒brain barrier impermeable therapeutics. Neuro Oncol. 2021 01 30; 23(1):63-75.
Wang W, Marín-Ramos NI, He H, Zeng S, Cho HY, Swenson SD, Zheng L, Epstein AL, Schönthal AH, Hofman FM, Chen L, Chen TC. PMID: 32877532; PMCID: PMC7850137.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Pharmacokinetic properties of the temozolomide perillyl alcohol conjugate (NEO212) in mice. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa160.
Cho HY, Swenson S, Thein TZ, Wang W, Wijeratne NR, Marín-Ramos NI, Katz JE, Hofman FM, Schönthal AH, Chen TC. PMID: 33392507; PMCID: PMC7764505.
View in:
PubMed Mentions:
5
-
Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas. PLoS One. 2020; 15(9):e0238238.
Minea RO, Duc TC, Swenson SD, Cho HY, Huang M, Hartman H, Hofman FM, Schönthal AH, Chen TC. PMID: 32881880; PMCID: PMC7470340.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
miR-18a Inhibits BMP4 and HIF-1α Normalizing Brain Arteriovenous Malformations. Circ Res. 2020 10 09; 127(9):e210-e231.
Marín-Ramos NI, Thein TZ, Ghaghada KB, Chen TC, Giannotta SL, Hofman FM. PMID: 32755283.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Preclinical studies of a novel snake venom-derived recombinant disintegrin with antitumor activity: A review. Biochem Pharmacol. 2020 11; 181:114149.
Schönthal AH, Swenson SD, Chen TC, Markland FS. PMID: 32663453.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice. Spine J. 2020 07; 20(7):1138-1151.
Danilov CA, Gu Y, Punj V, Wu Z, Steward O, Schönthal AH, Tahara SM, Hofman FM, Chen TC. PMID: 32145360.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model. Int J Mol Sci. 2020 Feb 20; 21(4).
Chen SH, Sun JM, Chen BM, Lin SC, Chang HF, Collins S, Chang D, Wu SF, Lu YC, Wang W, Chen TC, Kasahara N, Wang HE, Tai CK. PMID: 32093290; PMCID: PMC7073086.
View in:
PubMed Mentions:
7 Fields:
Translation:
AnimalsCells
-
Simultaneous measurement of perillyl alcohol and its metabolite perillic acid in plasma and lung after inhalational administration in Wistar rats. Drug Test Anal. 2020 Feb; 12(2):268-279.
de Lima DC, Rodrigues SV, Boaventura GT, Cho HY, Chen TC, Schönthal AH, Da Fonseca CO. PMID: 31800149.
View in:
PubMed Mentions:
5 Translation:
HumansAnimalsCells
-
Association Between Outdoor Air Pollution and Risk of Malignant and Benign Brain Tumors: The Multiethnic Cohort Study. JNCI Cancer Spectr. 2020 Apr; 4(2):pkz107.
Wu AH, Wu J, Tseng C, Yang J, Shariff-Marco S, Fruin S, Larson T, Setiawan VW, Masri S, Porcel J, Jain J, Chen TC, Stram DO, Marchand LL, Ritz B, Cheng I. PMID: 32211584; PMCID: PMC7083235.
View in:
PubMed Mentions:
8 Fields:
-
Cytotoxic impact of a perillyl alcohol-temozolomide conjugate, NEO212, on cutaneous T-cell lymphoma in vitro. Ther Adv Med Oncol. 2019; 11:1758835919891567.
Silva-Hirschberg C, Hartman H, Stack S, Swenson S, Minea RO, Davitz MA, Chen TC, Schönthal AH. PMID: 31839810; PMCID: PMC6900611.
View in:
PubMed Mentions:
7
-
Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. Neurochem Res. 2019 Nov; 44(11):2517-2526.
Fu J, Peng L, Wang W, He H, Zeng S, Chen TC, Chen Y. PMID: 31512113.
View in:
PubMed Mentions:
7 Fields:
Translation:
Animals
-
Inhibition of motility by NEO100 through the calpain-1/RhoA pathway. J Neurosurg. 2020 10 01; 133(4):1020-1031.
Marín-Ramos NI, Pérez-Hernández M, Tam A, Swenson SD, Cho HY, Thein TZ, Hofman FM, Chen TC. PMID: 31419797.
View in:
PubMed Mentions:
6 Fields:
-
NEO212 induces mitochondrial apoptosis and impairs autophagy flux in ovarian cancer. J Exp Clin Cancer Res. 2019 Jun 07; 38(1):239.
Song X, Liu L, Chang M, Geng X, Wang X, Wang W, Chen TC, Xie L, Song X. PMID: 31174569; PMCID: PMC6554966.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
-
Efficient brain targeting and therapeutic intracranial activity of bortezomib through intranasal co-delivery with NEO100 in rodent glioblastoma models. J Neurosurg. 2020 03 01; 132(3):959-967.
Wang W, Swenson S, Cho HY, Hofman FM, Schönthal AH, Chen TC. PMID: 30875688.
View in:
PubMed Mentions:
10 Fields:
-
The Rolipram-Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway. Mol Cancer Ther. 2019 03; 18(3):517-530.
Cho HY, Thein TZ, Wang W, Swenson SD, Fayngor RA, Ou M, Marín-Ramos NI, Schönthal AH, Hofman FM, Chen TC. PMID: 30647121.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
-
Distribution of cancer stem cells in two human brain gliomas. Oncol Lett. 2019 Feb; 17(2):2123-2130.
Peng L, Fu J, Wang W, Hofman FM, Chen TC, Chen L. PMID: 30719107; PMCID: PMC6351732.
View in:
PubMed Mentions:
11
-
NEO412: A temozolomide analog with transdermal activity in melanoma in vitro and in vivo. Oncotarget. 2018 Dec 11; 9(97):37026-37041.
Swenson S, Silva-Hirschberg C, Wang W, Singh A, Hofman FM, Chen KL, Schönthal AH, Chen TC. PMID: 30651933; PMCID: PMC6319336.
View in:
PubMed Mentions:
5 Fields:
-
Intranasal Perillyl Alcohol for Glioma Therapy: Molecular Mechanisms and Clinical Development. Int J Mol Sci. 2018 Dec 06; 19(12).
Chen TC, da Fonseca CO, Schönthal AH. PMID: 30563210; PMCID: PMC6321279.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells
-
A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice. Molecules. 2018 Nov 08; 23(11).
Swenson S, Minea RO, Tuan CD, Thein TZ, Chen TC, Markland FS. PMID: 30413113; PMCID: PMC6278533.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis. ACS Chem Biol. 2018 11 16; 13(11):3054-3058.
Darabedian N, Chen TC, Molina H, Pratt MR, Schönthal AH. PMID: 30395437.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
NEO212, a conjugate of temozolomide and perillyl alcohol, blocks the endothelial-to-mesenchymal transition in tumor-associated brain endothelial cells in glioblastoma. Cancer Lett. 2019 02 01; 442:170-180.
Marín-Ramos NI, Jhaveri N, Thein TZ, Fayngor RA, Chen TC, Hofman FM. PMID: 30392789.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Temozolomide-Perillyl alcohol conjugate impairs Mitophagy flux by inducing lysosomal dysfunction in non-small cell lung Cancer cells and sensitizes them to irradiation. J Exp Clin Cancer Res. 2018 Oct 16; 37(1):250.
Chang M, Song X, Geng X, Wang X, Wang W, Chen TC, Xie L, Song X. PMID: 30326943; PMCID: PMC6191917.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo. Cancers (Basel). 2018 Sep 28; 10(10).
Chen TC, Chan N, Minea RO, Hartman H, Hofman FM, Schönthal AH. PMID: 30274152; PMCID: PMC6209933.
View in:
PubMed Mentions:
3
-
Therapeutic Immunization against Glioblastoma. Int J Mol Sci. 2018 Aug 27; 19(9).
Schijns VEJC, Pretto C, Strik AM, Gloudemans-Rijkers R, Deviller L, Pierre D, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FPK, Hofman FM, Chen TC, Zidovetzki R, Bota DA, Stathopoulos A. PMID: 30150597; PMCID: PMC6163986.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansPHPublic Health
-
Phase II study of ERC1671 plus bevacizumab versus bevacizumab plus placebo in recurrent glioblastoma: interim results and correlations with CD4+ T-lymphocyte counts. CNS Oncol. 2018 07 01; 7(3):CNS22.
Bota DA, Chung J, Dandekar M, Carrillo JA, Kong XT, Fu BD, Hsu FP, Schönthal AH, Hofman FM, Chen TC, Zidovetzki R, Pretto C, Strik A, Schijns VE, Stathopoulos A. PMID: 30157683; PMCID: PMC6200061.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCellsCTClinical Trials
-
NEO212: sub-cytotoxic doses capable of inhibiting glioma stem cell invasion. Oncoscience. 2018 May; 5(5-6):148-149.
Marín-Ramos NI, Hofman FM, Chen TC. PMID: 30035171; PMCID: PMC6049296.
View in:
PubMed Mentions:
-
Influence of Treatment With Tumor-Treating Fields on Health-Related Quality of Life of Patients With Newly Diagnosed Glioblastoma: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 Apr 01; 4(4):495-504.
Taphoorn MJB, Dirven L, Kanner AA, Lavy-Shahaf G, Weinberg U, Taillibert S, Toms SA, Honnorat J, Chen TC, Sroubek J, David C, Idbaih A, Easaw JC, Kim CY, Bruna J, Hottinger AF, Kew Y, Roth P, Desai R, Villano JL, Kirson ED, Ram Z, Stupp R. PMID: 29392280; PMCID: PMC5885193.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansCTClinical Trials
-
NEO212 Inhibits Migration and Invasion of Glioma Stem Cells. Mol Cancer Ther. 2018 03; 17(3):625-637.
Marín-Ramos NI, Thein TZ, Cho HY, Swenson SD, Wang W, Schönthal AH, Chen TC, Hofman FM. PMID: 29440289; PMCID: PMC5935548.
View in:
PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
-
Temozolomide-perillyl alcohol conjugate downregulates O6-methylguanin DNA methltransferase via inducing ubiquitination-dependent proteolysis in non-small cell lung cancer. Cell Death Dis. 2018 02 09; 9(2):202.
Song X, Xie L, Chang M, Geng X, Wang X, Chen TC, Song X. PMID: 29426908; PMCID: PMC5833843.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram. Int J Mol Sci. 2018 Jan 17; 19(1).
Chen TC, Chan N, Labib S, Yu J, Cho HY, Hofman FM, Schönthal AH. PMID: 29342125; PMCID: PMC5796223.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Spine Surgery Complicated by an Engorged Lumbar Epidural Venous Plexus from Cerebrospinal Fluid Overshunting: A Case Report and Review of the Literature. World Neurosurg. 2018 Mar; 111:68-72.
Fredrickson VL, Patel A, Pham MH, Strickland BA, Ohiorhenuan I, Chen T. PMID: 29248773.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Transpedicular Corpectomy and Cage Placement in the Treatment of Traumatic Lumbar Burst Fractures. Clin Spine Surg. 2017 Oct; 30(8):360-366.
Pham MH, Tuchman A, Chen TC, Acosta FL, Hsieh PC, Liu JC. PMID: 28937458.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174.
Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH. PMID: 28450161.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. J Neurosurg. 2018 03; 128(3):695-700.
Wang W, Cho HY, Rosenstein-Sisson R, Marín Ramos NI, Price R, Hurth K, Schönthal AH, Hofman FM, Chen TC. PMID: 28409734.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
-
Heterocellular Contacts with Mouse Brain Endothelial Cells Via Laminin and α6β1 Integrin Sustain Subventricular Zone (SVZ) Stem/Progenitor Cells Properties. Front Cell Neurosci. 2016; 10:284.
Rosa AI, Grade S, Santos SD, Bernardino L, Chen TC, Relvas J, Hofman FM, Agasse F. PMID: 28018177; PMCID: PMC5156690.
View in:
PubMed Mentions:
8
-
Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma. Oncotarget. 2016 11 01; 7(44):71211-71222.
Krepler C, Xiao M, Samanta M, Vultur A, Chen HY, Brafford P, Reyes-Uribe PI, Halloran M, Chen T, He X, Hristova D, Liu Q, Samatar AA, Davies MA, Nathanson KL, Fukunaga-Kalabis M, Herlyn M, Villanueva J. PMID: 27655717; PMCID: PMC5342073.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Medulloblastoma initiation and spread: Where neurodevelopment, microenvironment and cancer cross pathways. J Neurosci Res. 2016 12; 94(12):1511-1519.
Martirosian V, Chen TC, Lin M, Neman J. PMID: 27629382.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
-
Perillyl Alcohol and Its Drug-Conjugated Derivatives as Potential Novel Methods of Treating Brain Metastases. Int J Mol Sci. 2016 Sep 02; 17(9).
Chen TC, Da Fonseca CO, Schönthal AH. PMID: 27598140; PMCID: PMC5037741.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
-
Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016 Mar 22; 7(12):13842-53.
Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman FM, Shih JC. PMID: 26871599; PMCID: PMC4924682.
View in:
PubMed Mentions:
44 Fields:
Translation:
HumansAnimalsCells
-
Temozolomide-perillyl alcohol conjugate induced reactive oxygen species accumulation contributes to its cytotoxicity against non-small cell lung cancer. Sci Rep. 2016 Mar 07; 6:22762.
Song X, Xie L, Wang X, Zeng Q, Chen TC, Wang W, Song X. PMID: 26949038; PMCID: PMC4780103.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansCells
-
Primary Intraosseous Meningioma. Neurosurg Clin N Am. 2016 Apr; 27(2):189-93.
Chen TC. PMID: 27012383.
View in:
PubMed Mentions:
18 Fields:
Translation:
Humans
-
Therapeutic effect of TMZ-POH on human nasopharyngeal carcinoma depends on reactive oxygen species accumulation. Oncotarget. 2016 Jan 12; 7(2):1651-62.
Xie L, Song X, Guo W, Wang X, Wei L, Li Y, Lv L, Wang W, Chen TC, Song X. PMID: 26625208; PMCID: PMC4811487.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial. JAMA. 2015 Dec 15; 314(23):2535-43.
Stupp R, Taillibert S, Kanner AA, Kesari S, Steinberg DM, Toms SA, Taylor LP, Lieberman F, Silvani A, Fink KL, Barnett GH, Zhu JJ, Henson JW, Engelhard HH, Chen TC, Tran DD, Sroubek J, Tran ND, Hottinger AF, Landolfi J, Desai R, Caroli M, Kew Y, Honnorat J, Idbaih A, Kirson ED, Weinberg U, Palti Y, Hegi ME, Ram Z. PMID: 26670971.
View in:
PubMed Mentions:
576 Fields:
Translation:
HumansCTClinical Trials
-
A novel drug conjugate, NEO212, targeting proneural and mesenchymal subtypes of patient-derived glioma cancer stem cells. Cancer Lett. 2016 Feb 28; 371(2):240-50.
Jhaveri N, Agasse F, Armstrong D, Peng L, Commins D, Wang W, Rosenstein-Sisson R, Vaikari VP, Santiago SV, Santos T, Chen L, Schönthal AH, Chen TC, Hofman FM. PMID: 26683773.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
-
Effects of fusion and conservative treatment on disc degeneration and rates of subsequent surgery after thoracolumbar fracture. J Neurosurg Spine. 2016 Mar; 24(3):476-82.
D'Oro A, Spoonamore MJ, Cohen JR, Acosta FL, Hsieh PC, Liu JC, Chen TC, Buser Z, Wang JC. PMID: 26637065.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Nanoparticle biointerfacing by platelet membrane cloaking. Nature. 2015 Oct 01; 526(7571):118-21.
Hu CM, Fang RH, Wang KC, Luk BT, Thamphiwatana S, Dehaini D, Nguyen P, Angsantikul P, Wen CH, Kroll AV, Carpenter C, Ramesh M, Qu V, Patel SH, Zhu J, Shi W, Hofman FM, Chen TC, Gao W, Zhang K, Chien S, Zhang L. PMID: 26374997; PMCID: PMC4871317.
View in:
PubMed Mentions:
526 Fields:
Translation:
HumansAnimalsCells
-
Chemotherapeutic effect of a novel temozolomide analog on nasopharyngeal carcinoma in vitro and in vivo. J Biomed Sci. 2015 Aug 19; 22:71.
Chen TC, Cho HY, Wang W, Wetzel SJ, Singh A, Nguyen J, Hofman FM, Schönthal AH. PMID: 26282951; PMCID: PMC4539921.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
-
A Conserved Glycan in the C2 Domain of HIV-1 Envelope Acts as a Molecular Switch to Control X4 Utilization by Clonal Variants with Identical V3 Loops. PLoS One. 2015; 10(6):e0128116.
Lombardi F, Nakamura KJ, Chen T, Sobrera ER, Tobin NH, Aldrovandi GM. PMID: 26083631; PMCID: PMC4471078.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
-
Development of the Metronomic Biofeedback Pump for leptomeningeal carcinomatosis: technical note. J Neurosurg. 2015 Aug; 123(2):362-72.
Chen TC, Napolitano GR, Adell F, Schönthal AH, Shachar Y. PMID: 25955873.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
Preclinical development and clinical use of perillyl alcohol for chemoprevention and cancer therapy. Am J Cancer Res. 2015; 5(5):1580-93.
Chen TC, Fonseca CO, Schönthal AH. PMID: 26175929; PMCID: PMC4497427.
View in:
PubMed Mentions:
47
-
First clinical results of a personalized immunotherapeutic vaccine against recurrent, incompletely resected, treatment-resistant glioblastoma multiforme (GBM) tumors, based on combined allo- and auto-immune tumor reactivity. Vaccine. 2015 May 28; 33(23):2690-6.
Schijns VE, Pretto C, Devillers L, Pierre D, Hofman FM, Chen TC, Mespouille P, Hantos P, Glorieux P, Bota DA, Stathopoulos A. PMID: 25865468; PMCID: PMC10494870.
-
Introduction. Neurooncology: update on therapeutic options. Neurosurg Focus. 2015 Mar; 38(3):E1.
Fults DW, Chen T, Bruce JN. PMID: 25727218.
View in:
PubMed Mentions: Fields:
Translation:
Humans
-
Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors. Neurosurg Focus. 2015 Mar; 38(3):E12.
Golden EB, Cho HY, Hofman FM, Louie SG, Schönthal AH, Chen TC. PMID: 25727221.
View in:
PubMed Mentions:
68 Fields:
Translation:
HumansAnimalsCells
-
Use of ERC-1671 Vaccine in a Patient with Recurrent Glioblastoma Multiforme after Progression during Bevacizumab Therapy: First Published Report. Perm J. 2015; 19(2):41-6.
Bota DA, Alexandru-Abrams D, Pretto C, Hofman FM, Chen TC, Fu B, Carrillo JA, Schijns VE, Stathopoulos A. PMID: 25785641; PMCID: PMC4403580.
View in:
PubMed Mentions:
10 Fields:
Translation:
Humans
-
Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals. Neurosurg Focus. 2015 Mar; 38(3):E8.
Wang W, Sivakumar W, Torres S, Jhaveri N, Vaikari VP, Gong A, Howard A, Golden EB, Louie SG, Schönthal AH, Hofman FM, Chen TC. PMID: 25727230.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
-
Stereotactic radiosurgery to the resection cavity for brain metastases: prognostic factors and outcomes. J Radiosurg SBRT. 2015; 3(3):179-186.
Abel RJ, Ji L, Yu C, Lederman A, Chen T, Liu C, Zada G, Kim PE, Apuzzo M, Chang EL. PMID: 29296400; PMCID: PMC5746332.
View in:
PubMed Mentions:
10
-
Tumor vasculature and glioma stem cells: Contributions to glioma progression. Cancer Lett. 2016 10 01; 380(2):545-551.
Jhaveri N, Chen TC, Hofman FM. PMID: 25527451.
View in:
PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
-
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo. Cancer Lett. 2015 Mar 28; 358(2):144-151.
Chen TC, Cho HY, Wang W, Nguyen J, Jhaveri N, Rosenstein-Sisson R, Hofman FM, Schönthal AH. PMID: 25524552.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
-
Introduction: Glioblastoma: an update on pathophysiology and management strategies. Neurosurg Focus. 2014 Dec; 37(6):Introduction.
Berger MS, Bruce JN, Chen TC, Zadeh G. PMID: 25434392.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy. Neurosurg Focus. 2014 Dec; 37(6):E12.
Golden EB, Cho HY, Jahanian A, Hofman FM, Louie SG, Schönthal AH, Chen TC. PMID: 25434381.
View in:
PubMed Mentions:
88 Fields:
Translation:
HumansAnimalsCells
-
Sequential administration of carbon nanotubes and near-infrared radiation for the treatment of gliomas. Front Oncol. 2014; 4:180.
Santos T, Fang X, Chen MT, Wang W, Ferreira R, Jhaveri N, Gundersen M, Zhou C, Pagnini P, Hofman FM, Chen TC. PMID: 25077069; PMCID: PMC4097104.
View in:
PubMed Mentions:
13
-
NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas. Mol Cancer Ther. 2014 Aug; 13(8):2004-17.
Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC. PMID: 24994771.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
-
Argonaute-2 promotes miR-18a entry in human brain endothelial cells. J Am Heart Assoc. 2014 May 16; 3(3):e000968.
Ferreira R, Santos T, Amar A, Gong A, Chen TC, Tahara SM, Giannotta SL, Hofman FM. PMID: 24837588; PMCID: PMC4309089.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Diffusion restriction in a non-enhancing metastatic brain tumor treated with bevacizumab - recurrent tumor or atypical necrosis? Clin Imaging. 2014 Sep-Oct; 38(5):724-6.
Sivasundaram L, Hazany S, Wagle N, Zada G, Chen TC, Lerner A, Go JL, D'Amore F, Law M, Shiroishi MS. PMID: 24910165.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
A novel temozolomide-perillyl alcohol conjugate exhibits superior activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo. Mol Cancer Ther. 2014 May; 13(5):1181-93.
Chen TC, Cho HY, Wang W, Barath M, Sharma N, Hofman FM, Schönthal AH. PMID: 24623736.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
-
A systematic review of inhaled intranasal therapy for central nervous system neoplasms: an emerging therapeutic option. J Neurooncol. 2014 Feb; 116(3):437-46.
Peterson A, Bansal A, Hofman F, Chen TC, Zada G. PMID: 24398618.
View in:
PubMed Mentions:
13 Fields:
Translation:
Humans
-
Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas. Neurosurg Focus. 2013 Dec; 35(6):E3.
Chang X, Shi L, Gao F, Russin J, Zeng L, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Wang K, Mack WJ. PMID: 24289128.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
MicroRNA-18a improves human cerebral arteriovenous malformation endothelial cell function. Stroke. 2014 Jan; 45(1):293-7.
Ferreira R, Santos T, Amar A, Tahara SM, Chen TC, Giannotta SL, Hofman FM. PMID: 24203843.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansCells
-
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. PLoS One. 2013; 8(6):e65695.
Thomas S, Sharma N, Gonzalez R, Pao PW, Hofman FM, Chen TC, Louie SG, Pirrung MC, Schönthal AH. PMID: 23755268; PMCID: PMC3675020.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Lumbar facet joint and intervertebral disc loading during simulated pelvic obliquity. Spine J. 2013 Nov; 13(11):1581-9.
Popovich JM, Welcher JB, Hedman TP, Tawackoli W, Anand N, Chen TC, Kulig K. PMID: 23706384.
View in:
PubMed Mentions:
9 Fields:
Translation:
Humans
-
DNA methylation in the malignant transformation of meningiomas. PLoS One. 2013; 8(1):e54114.
Gao F, Shi L, Russin J, Zeng L, Chang X, He S, Chen TC, Giannotta SL, Weisenberger DJ, Zada G, Mack WJ, Wang K. PMID: 23349797; PMCID: PMC3551961.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansCells
-
Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603.
Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. PMID: 22984531; PMCID: PMC3439413.
View in:
PubMed Mentions:
97 Fields:
Translation:
AnimalsCells
-
Perillyl alcohol for the treatment of temozolomide-resistant gliomas. Mol Cancer Ther. 2012 Nov; 11(11):2462-72.
Cho HY, Wang W, Jhaveri N, Torres S, Tseng J, Leong MN, Lee DJ, Goldkorn A, Xu T, Petasis NA, Louie SG, Schönthal AH, Hofman FM, Chen TC. PMID: 22933703.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent. Cancer Lett. 2012 Dec 30; 326(2):143-54.
Sharma N, Thomas S, Golden EB, Hofman FM, Chen TC, Petasis NA, Schönthal AH, Louie SG. PMID: 22863539.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansCells
-
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett. 2012 Dec 01; 325(1):63-71.
Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG, Schönthal AH. PMID: 22664238.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
-
Development of immune memory to glial brain tumors after tumor regression induced by immunotherapeutic Toll-like receptor 7/8 activation. Oncoimmunology. 2012 May 01; 1(3):298-305.
Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Kruse C, Jadus M, Chen TC, Schijns VE. PMID: 22737605; PMCID: PMC3382858.
View in:
PubMed Mentions:
17 Fields:
-
Exploring the Therapeutic Efficacy of Glioma Vaccines Based on Allo- and Syngeneic Antigens and Distinct Immunological Costimulation Activators. J Clin Cell Immunol. 2012; Suppl 5:004.
Stathopoulos A, Pretto C, Devillers L, Pierre D, Hofman FM, Epstein AL, Farghadani H, Kruse CA, Jadus MR, Chen TC, Schijns VE. PMID: 24955288; PMCID: PMC4062195.
View in:
PubMed Mentions:
3
-
Noscapine inhibits tumor growth in TMZ-resistant gliomas. Cancer Lett. 2011 Dec 22; 312(2):245-52.
Jhaveri N, Cho H, Torres S, Wang W, Schönthal AH, Petasis NA, Louie SG, Hofman FM, Chen TC. PMID: 21925789.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansAnimals
-
Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms. Neurosurg Focus. 2011 May; 30(5):E7.
Pham MH, Zada G, Mosich GM, Chen TC, Giannotta SL, Wang K, Mack WJ. PMID: 21529178.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
A phase 1/2 study of orally administered synthetic hypericin for treatment of recurrent malignant gliomas. Cancer. 2011 Nov 01; 117(21):4905-15.
Couldwell WT, Surnock AA, Tobia AJ, Cabana BE, Stillerman CB, Forsyth PA, Appley AJ, Spence AM, Hinton DR, Chen TC. PMID: 21456013.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCTClinical Trials
-
Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett. 2011 Mar 28; 302(2):100-8.
Chen TC, Wang W, Golden EB, Thomas S, Sivakumar W, Hofman FM, Louie SG, Schönthal AH. PMID: 21257259.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
-
Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response. Curr Pharm Des. 2011; 17(23):2428-38.
Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. PMID: 21827419.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
-
A technical description of the brain tumor window model: an in vivo model for the evaluation of intraoperative contrast agents. Acta Neurochir Suppl. 2011; 109:259-63.
Orringer DA, Chen T, Huang DL, Philbert M, Kopelman R, Sagher O. PMID: 20960353; PMCID: PMC4438080.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
GRP78/BiP modulation of GRP78/BiP in altering sensitivity to chemotherapy. Methods Enzymol. 2011; 491:25-36.
Chen TC. PMID: 21329792.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
-
Phase 1/pharmacology study of intraperitoneal topotecan alone and with cisplatin: potential for consolidation in ovarian cancer. Cancer Chemother Pharmacol. 2011 Aug; 68(2):457-63.
Andreopoulou E, Chen T, Liebes L, Curtin J, Blank S, Wallach R, Hochster H, Muggia F. PMID: 21069334.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansCTClinical Trials
-
A novel method for administering intrathecal chemotherapy in patients with leptomeningeal metastases and shunted hydrocephalus: case report. Neurosurgery. 2010 Sep; 67(3 Suppl Operative):onsE306-7; discussion onsE307.
Zada G, Chen TC. PMID: 20679917.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivo. Laboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94.
Wang W, Ghandi A, Liebes L, Louie SG, Hofman FM, Schönthal AH, Chen TC. PMID: 20415520.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
-
The brain tumor window model: a combined cranial window and implanted glioma model for evaluating intraoperative contrast agents. Neurosurgery. 2010 Apr; 66(4):736-43.
Orringer DA, Chen T, Huang DL, Armstead WM, Hoff BA, Koo YE, Keep RF, Philbert MA, Kopelman R, Sagher O. PMID: 20305495; PMCID: PMC3970731.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
A-Mode ultrasound guidance for pedicle screw advancement in ovine vertebral bodies. Spine J. 2010 May; 10(5):422-32.
Raphael DT, Chang JH, Zhang YP, Kudija D, Chen TC, Shung KK. PMID: 20347399; PMCID: PMC2860664.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature. Mol Cancer Ther. 2010 Mar; 9(3):631-41.
Virrey JJ, Liu Z, Cho HY, Kardosh A, Golden EB, Louie SG, Gaffney KJ, Petasis NA, Schönthal AH, Chen TC, Hofman FM. PMID: 20197398.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
An intensive, progressive exercise program reduces disability and improves functional performance in patients after single-level lumbar microdiskectomy. Phys Ther. 2009 Nov; 89(11):1145-57.
Kulig K, Beneck GJ, Selkowitz DM, Popovich JM, Ge TT, Flanagan SP, Poppert EM, Yamada KA, Powers CM, Azen S, Winstein CJ, Gordon J, Samudrala S, Chen TC, Shamie AN, Khoo LT, Spoonamore MJ, Wang JC, Physical Therapy Clinical Research Network (PTClinResNet). PMID: 19778981.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
In vitro characterization of a targeted, dye-loaded nanodevice for intraoperative tumor delineation. Neurosurgery. 2009 May; 64(5):965-71; discussion 971-2.
Orringer DA, Koo YE, Chen T, Kim G, Hah HJ, Xu H, Wang S, Keep R, Philbert MA, Kopelman R, Sagher O. PMID: 19404156; PMCID: PMC2701445.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansCells
-
Glioma-associated endothelial cells are chemoresistant to temozolomide. J Neurooncol. 2009 Oct; 95(1):13-22.
Virrey JJ, Golden EB, Sivakumar W, Wang W, Pen L, Schönthal AH, Hofman FM, Chen TC. PMID: 19381445.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress. Cancer Lett. 2009 Sep 08; 282(1):87-97.
Cho HY, Thomas S, Golden EB, Gaffney KJ, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. PMID: 19345476.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood. 2009 Jun 04; 113(23):5927-37.
Golden EB, Lam PY, Kardosh A, Gaffney KJ, Cadenas E, Louie SG, Petasis NA, Chen TC, Schönthal AH. PMID: 19190249.
View in:
PubMed Mentions:
90 Fields:
Translation:
HumansAnimalsCells
-
Pharmacogenomics of brain cancer and personalized medicine in malignant gliomas. Future Oncol. 2008 Aug; 4(4):525-34.
Shai RM, Reichardt JK, Chen TC. PMID: 18684063.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
-
Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells. Mol Cancer Res. 2008 Aug; 6(8):1268-75.
Virrey JJ, Dong D, Stiles C, Patterson JB, Pen L, Ni M, Schönthal AH, Chen TC, Hofman FM, Lee AS. PMID: 18708359; PMCID: PMC2593417.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansCells
-
Increased survivin expression confers chemoresistance to tumor-associated endothelial cells. Am J Pathol. 2008 Aug; 173(2):575-85.
Virrey JJ, Guan S, Li W, Schönthal AH, Chen TC, Hofman FM. PMID: 18599610; PMCID: PMC2475793.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansCells
-
Therapeutic vaccination against malignant gliomas based on allorecognition and syngeneic tumor antigens: proof of principle in two strains of rat. Vaccine. 2008 Mar 25; 26(14):1764-72.
Stathopoulos A, Samuelson C, Milbouw G, Hermanne JP, Schijns VE, Chen TC. PMID: 18336964.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib. Cancer Res. 2008 Feb 01; 68(3):843-51.
Kardosh A, Golden EB, Pyrko P, Uddin J, Hofman FM, Chen TC, Louie SG, Petasis NA, Schönthal AH. PMID: 18245486.
View in:
PubMed Mentions:
55 Fields:
Translation:
HumansAnimalsCells
-
Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs. Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208.
Schönthal AH, Chen TC, Hofman FM, Louie SG, Petasis NA. PMID: 18230053.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansAnimals
-
HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Res. 2007 Nov 15; 67(22):10920-8.
Pyrko P, Kardosh A, Wang W, Xiong W, Schönthal AH, Chen TC. PMID: 18006837.
View in:
PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
-
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas. Cancer Res. 2007 Oct 15; 67(20):9809-16.
Pyrko P, Schönthal AH, Hofman FM, Chen TC, Lee AS. PMID: 17942911.
View in:
PubMed Mentions:
209 Fields:
Translation:
HumansCells
-
Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib. Mol Cancer Ther. 2007 Apr; 6(4):1262-75.
Pyrko P, Kardosh A, Liu YT, Soriano N, Xiong W, Chow RH, Uddin J, Petasis NA, Mircheff AK, Farley RA, Louie SG, Chen TC, Schönthal AH. PMID: 17431104.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
-
Irinotecan: a potential new chemotherapeutic agent for atypical or malignant meningiomas. J Neurosurg. 2007 Mar; 106(3):455-62.
Gupta V, Su YS, Samuelson CG, Liebes LF, Chamberlain MC, Hofman FM, Schönthal AH, Chen TC. PMID: 17367069.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Glioma-associated endothelial cells show evidence of replicative senescence. Exp Cell Res. 2007 Apr 01; 313(6):1192-202.
Charalambous C, Virrey J, Kardosh A, Jabbour MN, Qazi-Abdullah L, Pen L, Zidovetzki R, Schönthal AH, Chen TC, Hofman FM. PMID: 17291495.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansCells
-
Nelfinavir potentiation of imatinib cytotoxicity in meningioma cells via survivin inhibition. Neurosurg Focus. 2007; 23(4):E9.
Gupta V, Samuleson CG, Su S, Chen TC. PMID: 17961046.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
-
Adjuvant therapy for unresectable meningiomas: benign and malignant. Neurosurg Focus. 2007; 23(4):1.
Chen TC, Chamberlain MC. PMID: 18081514.
View in:
PubMed Mentions:
1 Fields:
Translation:
Humans
-
Primary intraosseous meningioma. Neurosurg Focus. 2007; 23(4):E13.
Elder JB, Atkinson R, Zee CS, Chen TC. PMID: 17961037.
View in:
PubMed Mentions:
37 Fields:
Translation:
Humans
-
Efficacy of celecoxib in the treatment of CNS lymphomas: an in vivo model. Neurosurg Focus. 2006 Nov 15; 21(5):E14.
Wang W, Kardosh A, Su YS, Schonthal AH, Chen TC. PMID: 17134116.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
-
Surgical interventions for primary central nervous system lymphoma. Neurosurg Focus. 2006 Nov 15; 21(5):E13.
Elder JB, Chen TC. PMID: 17134115.
View in:
PubMed Mentions:
11 Fields:
Translation:
Humans
-
Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. Mol Cancer. 2006 May 18; 5:19.
Pyrko P, Soriano N, Kardosh A, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen CS, Chen TC, Schönthal AH. PMID: 16707021; PMCID: PMC1479836.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
-
Characteristics of tumor-associated endothelial cells derived from glioblastoma multiforme. Neurosurg Focus. 2006 Apr 15; 20(4):E22.
Charalambous C, Chen TC, Hofman FM. PMID: 16709028.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansCells
-
Enhancement of glioblastoma cell killing by combination treatment with temozolomide and tamoxifen or hypericin. Neurosurg Focus. 2006 Apr 15; 20(4):E20.
Gupta V, Su YS, Wang W, Kardosh A, Liebes LF, Hofman FM, Schönthal AH, Chen TC. PMID: 16709026.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
-
Use of replication-competent retroviral vectors in an immunocompetent intracranial glioma model. Neurosurg Focus. 2006 Apr 15; 20(4):E25.
Wang W, Tai CK, Kershaw AD, Solly SK, Klatzmann D, Kasahara N, Chen TC. PMID: 16709031; PMCID: PMC8295718.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
-
Fibroblast growth factor-2-retargeted adenoviral vector for selective transduction of primary glioblastoma multiforme endothelial cells. Neurosurg Focus. 2006 Apr 15; 20(4):E26.
Gupta V, Wang W, Sosnowski BA, Hofman FM, Chen TC. PMID: 16709032.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Multiple signaling pathways are involved in endothelin-1-induced brain endothelial cell migration. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C155-64.
Milan J, Charalambous C, Elhag R, Chen TC, Li W, Guan S, Hofman FM, Zidovetzki R. PMID: 16452160.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
-
Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy. J Neurosurg. 2005 Dec; 103(6):1058-66.
Wang W, Zhu NL, Chua J, Swenson S, Costa FK, Schmitmeier S, Sosnowski BA, Shichinohe T, Kasahara N, Chen TC. PMID: 16381193.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
-
Interleukin-8 differentially regulates migration of tumor-associated and normal human brain endothelial cells. Cancer Res. 2005 Nov 15; 65(22):10347-54.
Charalambous C, Pen LB, Su YS, Milan J, Chen TC, Hofman FM. PMID: 16288024.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma. Mol Ther. 2005 Nov; 12(5):842-51.
Tai CK, Wang WJ, Chen TC, Kasahara N. PMID: 16257382; PMCID: PMC8185609.
View in:
PubMed Mentions:
61 Fields:
Translation:
HumansAnimalsCells
-
The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model. J Neurosurg. 2005 Sep; 103(3):526-37.
Pyrko P, Wang W, Markland FS, Swenson SD, Schmitmeier S, Schönthal AH, Chen TC. PMID: 16235686.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
-
Multitarget inhibition of drug-resistant multiple myeloma cell lines by dimethyl-celecoxib (DMC), a non-COX-2 inhibitory analog of celecoxib. Blood. 2005 Dec 15; 106(13):4330-8.
Kardosh A, Soriano N, Liu YT, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. PMID: 16123214.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansCells
-
Potent mimicry of fibronectin-induced intracellular signaling in glioma cells by the homodimeric snake venom disintegrin contortrostatin. Neurosurgery. 2005 Jul; 57(1):141-53; discussion 141-53.
Schmitmeier S, Markland FS, Schönthal AH, Chen TC. PMID: 15987550.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Dimethyl-celecoxib (DMC), a derivative of celecoxib that lacks cyclooxygenase-2-inhibitory function, potently mimics the anti-tumor effects of celecoxib on Burkitt's lymphoma in vitro and in vivo. Cancer Biol Ther. 2005 May; 4(5):571-82.
Kardosh A, Wang W, Uddin J, Petasis NA, Hofman FM, Chen TC, Schönthal AH. PMID: 15846081.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Functional and phenotypic differences between glioblastoma multiforme-derived and normal human brain endothelial cells. J Neurosurg. 2005 Apr; 102(4):699-705.
Charalambous C, Hofman FM, Chen TC. PMID: 15871513.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
-
Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent. Pathophysiol Haemost Thromb. 2005; 34(4-5):177-83.
Minea R, Swenson S, Costa F, Chen TC, Markland FS. PMID: 16707923.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
-
Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines. Cancer Biol Ther. 2004 Jan; 3(1):55-62.
Kardosh A, Blumenthal M, Wang WJ, Chen TC, Schönthal AH. PMID: 14726653.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansCells
-
Combination therapy with irinotecan and protein kinase C inhibitors in malignant glioma. Cancer. 2003 May 01; 97(9 Suppl):2363-73.
Chen TC, Su S, Fry D, Liebes L. PMID: 12712458.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors. Hum Gene Ther. 2003 Jan 20; 14(2):117-27.
Wang WJ, Tai CK, Kasahara N, Chen TC. PMID: 12614563; PMCID: PMC8295717.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
-
Functional effect of contortrostatin, a snake venom disintegrin, on human glioma cell invasion in vitro. Cell Commun Adhes. 2003 Jan-Feb; 10(1):1-16.
Schmitmeier S, Markland FS, Ritter MR, Sawcer DE, Chen TC. PMID: 12881036.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
-
Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway. Cancer Lett. 2002 Nov 28; 185(2):131-8.
Simard M, Zhang W, Hinton DR, Chen TC, Weiss MH, Su YZ, Gopalakrishna R, Law RE, Couldwell WT. PMID: 12169386.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
-
The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells. Cancer Biol Ther. 2002 May-Jun; 1(3):268-76.
Chen TC, Wadsten P, Su S, Rawlinson N, Hofman FM, Hill CK, Schönthal AH. PMID: 12432276.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansCells