Uttam Kumar Sinha, MD

Title(s)Professor of Otolaryngology--Head and Neck Surgery
SchoolKeck School of Medicine of Usc
Address1537 Norfolk Street Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 5790
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    Other Positions
    Title(s)Medical Director of Head and Neck Surgery

    Title(s)Watt Family Endowed Chair for Head and Neck Cancers


    Collapse Biography 
    Collapse Awards and Honors
    1992Alpha Omega Alpha (Gamma Chapter) as an Outstanding Resident
    House Ear Institute1986Rupley Fellowship
    Calcutta University1977Gold Medal for highest marks in General Surgery
    Calcutta University1977Annual Scholarship for Academic Merit
    Government of India1973National Scholarship for Academic Merit

    Collapse Overview 
    Collapse Overview
    Dr. Uttam K. Sinha graduated with distinction from the Calcutta University, India in 1985. He was invited by the House Ear Institute and University of Southern California where he started his research career in molecular biology of neuroscience and cancer. He then finished residency in Otolaryngology-Head and Neck Surgery at USC. He continued to peruse academic career and completed a clinical fellowship in Microvascular and Plastic and Reconstructive Surgery in Mount Sinai Hospital, New York. He then went to Leon, France to complete a clinical fellowship in laryngology. Subsequently, he joined the faculty of the Department of Otolaryngology-Head and Neck Surgery at USC. Because of his academic achievements, leadership, teaching and research, he became Chief and Residency Program Director for the department. His major areas of research are head and neck cancer, thyroid cancer, plastic and reconstructive surgery, trauma, and speech and swallowing. By using nanotechnology, Dr. Sinha and his team are able to detect cancer cell in the saliva and serum. He is also studying the mechanism of metastasis. Dysphagia (difficulty in swallowing) is a common symptom following head and neck cancer therapy. Dr. Sinha and his team introduced a novel treatment called neuromuscular electrical stimulation (NMES) for rehabilitation of swallowing using a new “platform” technology called BION. He received multiple federal and foundation grants. His dedication to patient care and research made him world authority in head and neck diseases. To further the research endeavors, Dr. Sinha has established collaboration with multiple national and international institutes from England, France, India, China and Mexico. Three years ago Dr. Sinha launched a Patient Survivorship Program (http://hncsupport.org). The Support Group is actively involved in patient education and promoting awareness about head and neck cancer.



    https://keck.usc.edu/otolaryngology/

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer. Nat Commun. 2024 Mar 20; 15(1):2484. Jiang Y, Zheng Y, Zhang YW, Kong S, Dong J, Wang F, Ziman B, Gery S, Hao JJ, Zhou D, Zhou J, Ho AS, Sinha UK, Chen J, Zhang S, Yin C, Wei DD, Hazawa M, Pan H, Lu Z, Wei WQ, Wang MR, Koeffler HP, Lin DC, Jiang YY. PMID: 38509096; PMCID: PMC10954759.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Activation of Epstein-Barr Virus' Lytic Cycle in Nasopharyngeal Carcinoma Cells by NEO212, a Conjugate of Perillyl Alcohol and Temozolomide. Cancers (Basel). 2024 Feb 26; 16(5). Hartman-Houstman H, Swenson S, Minea RO, Sinha UK, Chiang MF, Chen TC, Schönthal AH. PMID: 38473298; PMCID: PMC10931041.
      View in: PubMed   Mentions:
    3. Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma. Cell Death Dis. 2024 Feb 19; 15(2):152. Ziman B, Yang Q, Zheng Y, Sheth M, Nam C, Zhao H, Zhang L, Hu B, Bhowmick NA, Sinha UK, Lin DC. PMID: 38373993; PMCID: PMC10876663.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Free Flap Outcomes for Head and Neck Surgery in Patients with COVID-19. Laryngoscope. 2023 Nov 08. Domack A, Sandelski MM, Ali S, Blackwell KE, Buchakjian M, Bur AM, Cannady SB, Castellanos CX, Ducic Y, Ghanem TA, Huang AT, Jackson RS, Kokot N, Li S, Pipkorn P, Puram SV, Rezaee R, Rajasekaran K, Shnayder Y, Sinha UK, Sukato D, Suresh N, Tamaki A, Thomas CM, Thorpe EJ, Wax MK, Yang S, Ziegler A, Pittman AL. PMID: 37937733.
      View in: PubMed   Mentions:    Fields:    
    5. Comprehensive analyses of partially methylated domains and differentially methylated regions in esophageal cancer reveal both cell-type- and cancer-specific epigenetic regulation. Genome Biol. 2023 08 24; 24(1):193. Zheng Y, Ziman B, Ho AS, Sinha UK, Xu LY, Li EM, Koeffler HP, Berman BP, Lin DC. PMID: 37620896; PMCID: PMC10463844.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    6. Comparison of Free Flap Outcomes at a University Hospital versus County Hospital Setting for Head and Neck Reconstruction. Int Arch Otorhinolaryngol. 2023 Apr; 27(2):e183-e190. Swanson MS, Gantz O, Zhou S, Fisher L, Kezirian E, Tan MH, Zhang Y, Chambers TN, Sinha UK, Kokot N. PMID: 37125366; PMCID: PMC10147463.
      View in: PubMed   Mentions:
    7. A novel role of master regulator transcription factor in anti-tumor immunity and cancer immunotherapy. Theranostics. 2023; 13(6):1823-1825. Sinha UK, Lin DC. PMID: 37064876; PMCID: PMC10091883.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. Opioid Sparing Multimodal Analgesia for Transoral Robotic Surgery: Improved Analgesia and Narcotic Use Reduction. OTO Open. 2023 Jan-Mar; 7(1):e17. Castellanos CX, Paoletti M, Ulloa R, Kim C, Fong M, Xepoleas M, Sinha U, Kokot N, Swanson MS. PMID: 36998552; PMCID: PMC10046737.
      View in: PubMed   Mentions:
    9. Single-cell genomics identifies immune response to neoadjuvant chemoradiotherapy. EBioMedicine. 2022 12; 86:104389. Sinha UK, Kast WM, Lin DC. PMID: 36463779; PMCID: PMC9718959.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models. Comput Struct Biotechnol J. 2022; 20:5309-5315. Zhao H, Collet C, Peng D, Sinha UK, Lin DC. PMID: 36212534; PMCID: PMC9513696.
      View in: PubMed   Mentions: 1  
    11. Human papillomavirus detection in oral rinses and history of tonsillectomy in U.S. adults. Am J Otolaryngol. 2022 Nov-Dec; 43(6):103558. Wu FM, Yu AJ, Choi JS, Swanson MS, Chambers TN, Kokot NC, Sinha UK. PMID: 36029622.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Variation in compensatory strategies as a function of target constriction degree in post-glossectomy speech. JASA Express Lett. 2022 Apr; 2(4):045205. Hagedorn C, Lu Y, Toutios A, Sinha U, Goldstein L, Narayanan S. PMID: 35495774; PMCID: PMC9036259.
      View in: PubMed   Mentions:    Fields:    
    13. An Exploration of Online Support Community Participation Among Patients With Vestibular Disorders. Laryngoscope. 2022 09; 132(9):1835-1842. Vanstrum EB, Doherty JK, Sinha UK, Voelker CCJ, Bassett AM. PMID: 34889460.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Improved Swallow Outcomes with Early Intervention using Combined Swallow Therapy in Advanced Oropharyngeal Carcinoma. J Laryngol Otol. 2021 Oct 27; 1-22. Kwon DI, Villegas BC, Ouyoung LM, Sinha UK. PMID: 34702385.
      View in: PubMed   Mentions:    Fields:    
    15. Complexity of vocal tract shaping in glossectomy patients and typical speakers: A principal component analysis. J Acoust Soc Am. 2021 06; 149(6):4437. Hagedorn C, Kim J, Sinha U, Goldstein L, Narayanan SS. PMID: 34241468; PMCID: PMC8221817.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. Outcomes of Combined Antegrade-Retrograde Dilations for Radiation-Induced Esophageal Strictures in Head and Neck Cancer Patients. Dysphagia. 2021 12; 36(6):1040-1047. Liu D, Pickering T, Kokot N, Crookes P, Sinha UK, Swanson MS. PMID: 33386998; PMCID: PMC8559520.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Evidence for AJUBA-catenin-CDH4-linked differentiation resistance of mesenchymal stem cells implies tumorigenesis and progression of head and neck squamous cell carcinoma: a single-cell transcriptome approach. Blood Genom. 2021; 5(1):29-39. Stucky A, Gao L, Sun L, Li SC, Chen X, Park TH, Cai J, Kabeer MH, Zhang X, Sinha UK, Zhong JF. PMID: 34368804; PMCID: PMC8346230.
      View in: PubMed   Mentions:
    18. Evaluation of lymph node ratio and lymph node yield as prognosticators of locoregional recurrence in p16-associated oropharyngeal squamous cell carcinoma. Head Neck. 2020 10; 42(10):2811-2820. Nurimba M, Hines W, Sinha U, Mathew A, Kokot N, Swanson M. PMID: 32542889; PMCID: PMC8559522.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    19. ERAS for Head and Neck Tissue Transfer Reduces Opioid Usage, Peak Pain Scores, and Blood Utilization. Laryngoscope. 2021 03; 131(3):E792-E799. Clark BS, Swanson M, Widjaja W, Cameron B, Yu V, Ershova K, Wu FM, Vanstrum EB, Ulloa R, Heng A, Nurimba M, Kokot N, Kochhar A, Sinha UK, Kim MP, Dickerson S. PMID: 32516508; PMCID: PMC8559523.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. Enhanced Recovery After Surgery-Based Perioperative Protocol for Head and Neck Free Flap Reconstruction. OTO Open. 2020 Apr-Jun; 4(2):2473974X20931037. Bertelsen C, Hur K, Nurimba M, Choi J, Acevedo JR, Jackanich A, Sinha UK, Kochhar A, Kokot N, Swanson M. PMID: 32537554; PMCID: PMC7268136.
      View in: PubMed   Mentions: 8  
    21. Prevalence of oral human papillomavirus infections by race in the United States: An association with sexual behavior. Oral Dis. 2020 Jul; 26(5):930-940. Choi JS, Tang L, Yu AJ, Swanson MS, Chambers TN, Kokot NC, Sinha UK. PMID: 32011771.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Association of Race/Ethnicity, Stage, and Survival in Oral Cavity Squamous Cell Carcinoma: A SEER Study. OTO Open. 2019 Oct-Dec; 3(4):2473974X19891126. Yu AJ, Choi JS, Swanson MS, Kokot NC, Brown TN, Yan G, Sinha UK. PMID: 31840132; PMCID: PMC6904786.
      View in: PubMed   Mentions: 18  
    23. Association of insurance type with time course of care in head and neck cancer management. Laryngoscope. 2020 11; 130(11):E587-E592. Itamura K, Kokot N, Sinha U, Swanson M. PMID: 31756005.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    24. A Practical Mathematic Method to Predict and Manage Hypocalcemia After Parathyroidectomy and Thyroidectomy. Ann Otol Rhinol Laryngol. 2020 Jan; 129(1):70-77. Liu C, Tang L, Goel P, Chambers T, Kokot N, Sinha U, Maceri D. PMID: 31510765.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    25. Outcomes of Self-Esophageal Dilation for Head and Neck Cancer Patients. Am J Speech Lang Pathol. 2019 08 09; 28(3):1060-1066. Sinha UK, Swanson MS, Villegas BC, Ouyoung LM, Kokot N. PMID: 31112391.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    26. Rapidly Enlarging Parapharyngeal Mass. JAMA Otolaryngol Head Neck Surg. 2018 12 01; 144(12):1178-1179. Kim-Orden N, Chambers T, Sinha U. PMID: 30267038.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. The molecular mechanisms of increased radiosensitivity of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC): an extensive review. J Otolaryngol Head Neck Surg. 2018 Sep 21; 47(1):59. Liu C, Mann D, Sinha UK, Kokot NC. PMID: 30241572; PMCID: PMC6150985.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    28. How Does Smoking Change the Clinicopathological Characteristics of Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma? One Medical Center Experience. Clin Med Insights Ear Nose Throat. 2018; 11:1179550618792248. Liu C, Talmor G, Low GM, Wang TV, Mann DS, Sinha UK, Kokot NC. PMID: 30147388; PMCID: PMC6102755.
      View in: PubMed   Mentions: 2  
    29. Outcomes of reconstruction after temporal bone resection for malignancy. J Craniomaxillofac Surg. 2018 Oct; 46(10):1856-1861. Bertelsen C, Simsolo E, Maceri D, Sinha U, Kokot N. PMID: 30170960.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Effects of Resonance Voice Therapy on Hormone-Related Vocal Disorders in Professional Singers: A Pilot Study. Clin Med Insights Ear Nose Throat. 2018; 11:1179550618786934. Ouyoung LM, Villegas BC, Liu C, Talmor G, Sinha UK. PMID: 30093799; PMCID: PMC6081754.
      View in: PubMed   Mentions: 2  
    31. Interdisciplinary Telemedicine in the Management of Dysphagia in Head and Neck. Dysphagia. 2018 Aug; 33(4):474-480. Mayadevi M, Thankappan K, Limbachiya SV, Vidhyadharan S, Villegas B, Ouyoung M, Balasubramanian D, Menon JR, Sinha U, Iyer S. PMID: 29404691.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    32. Transoral surgery vs intensity-modulated radiotherapy for early supraglottic cancer: a systematic review. Curr Opin Otolaryngol Head Neck Surg. 2017 Apr; 25(2):133-141. Swanson MS, Low G, Sinha UK, Kokot N. PMID: 28106658.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    33. Management of Chyle Leak after Head and Neck Surgery: Review of Current Treatment Strategies. Int J Otolaryngol. 2017; 2017:8362874. Delaney SW, Shi H, Shokrani A, Sinha UK. PMID: 28203252; PMCID: PMC5288539.
      View in: PubMed   Mentions: 40  
    34. Overcoming radioresistance in head and neck squamous cell carcinoma. Oral Oncol. 2016 12; 63:44-51. Yamamoto VN, Thylur DS, Bauschard M, Schmale I, Sinha UK. PMID: 27938999.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    35. Erratum to "The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma" [Oral Oncol. 61 (2016) 27-30]. Oral Oncol. 2016 11; 62:e5. Low GM, Thylur DS, Yamamoto V, Sinha UK. PMID: 27806837.
      View in: PubMed   Mentions:    Fields:    
    36. The effect of human papillomavirus on DNA repair in head and neck squamous cell carcinoma. Oral Oncol. 2016 10; 61:27-30. Low GM, Thylur DS, Yamamoto V, Sinha UK. PMID: 27688101.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    37. Neuromuscular electrical stimulation improves radiation-induced fibrosis through Tgf-Β1/MyoD homeostasis in head and neck cancer. J Surg Oncol. 2016 Jul; 114(1):27-31. Peng G, Masood K, Gantz O, Sinha U. PMID: 27144672.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    38. The Role of HPV in Head and Neck Cancer Stem Cell Formation and Tumorigenesis. Cancers (Basel). 2016 Feb 19; 8(2). Swanson MS, Kokot N, Sinha UK. PMID: 26907349; PMCID: PMC4773747.
      View in: PubMed   Mentions: 11  
    39. Device Life of Two Generations of Provox Voice Prostheses. Ann Otol Rhinol Laryngol. 2016 Jun; 125(6):501-7. Thylur DS, Villegas BC, Fisher LM, Sinha UK, Kokot N. PMID: 26747630.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    40. ABCLOVE: Voice therapy outcomes for patients with head and neck cancer. Head Neck. 2016 04; 38 Suppl 1:E1810-3. Ouyoung LM, Swanson MS, Villegas BC, Damodar D, Kokot N, Sinha UK. PMID: 26689974.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Use of Octreotide for the Management of Chyle Fistula Following Neck Dissection. JAMA Otolaryngol Head Neck Surg. 2015 Aug; 141(8):723-7. Swanson MS, Hudson RL, Bhandari N, Sinha UK, Maceri DR, Kokot N. PMID: 26135979.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Rationale for combined blockade of PD-1 and CTLA-4 in advanced head and neck squamous cell cancer—review of current data. Oral Oncol. 2015 Jan; 51(1):12-5. Swanson MS, Sinha UK. PMID: 25459157.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    43. Defining the localization and molecular characteristic of minor salivary gland label-retaining cells. Stem Cells. 2014 Aug; 32(8):2267-77. Zhang H, Boddupally K, Kandyba E, Kobielak K, Chen Y, Zu S, Krishnan R, Sinha U, Kobielak A. PMID: 24715701; PMCID: PMC4106972.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. Diagnosis and management of merkel cell carcinoma of the head and neck: current trends and controversies. Cancers (Basel). 2014 Jun 27; 6(3):1256-66. Swanson MS, Sinha UK. PMID: 24978433; PMCID: PMC4190540.
      View in: PubMed   Mentions: 3  
    45. Bacterial biofilms and increased bacterial counts are associated with airway stenosis. Otolaryngol Head Neck Surg. 2014 May; 150(5):834-40. Mazhar K, Gunawardana M, Webster P, Hochstim C, Koempel J, Kokot N, Sinha U, Rice D, Baum M. PMID: 24515969.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    46. Use of the supraclavicular artery island flap for reconstruction of cervicofacial defects. Otolaryngol Head Neck Surg. 2014 Feb; 150(2):222-8. Kokot N, Mazhar K, Reder LS, Peng GL, Sinha UK. PMID: 24316793.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Evaluation of swallow function after tongue cancer treatment using real-time magnetic resonance imaging: a pilot study. JAMA Otolaryngol Head Neck Surg. 2013 Dec; 139(12):1312-9. Zu Y, Narayanan SS, Kim YC, Nayak K, Bronson-Lowe C, Villegas B, Ouyoung M, Sinha UK. PMID: 24177574; PMCID: PMC5110428.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    48. The supraclavicular artery island flap in head and neck reconstruction: applications and limitations. JAMA Otolaryngol Head Neck Surg. 2013 Nov; 139(11):1247-55. Kokot N, Mazhar K, Reder LS, Peng GL, Sinha UK. PMID: 24158458.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    49. A novel orthotopic mouse model of head and neck cancer and lymph node metastasis. Oncogenesis. 2013 Sep 09; 2:e68. Masood R, Hochstim C, Cervenka B, Zu S, Baniwal SK, Patel V, Kobielak A, Sinha UK. PMID: 24018643; PMCID: PMC3816223.
      View in: PubMed   Mentions: 16  
    50. Solitary fibrous tumor of the postcricoid region: a case report and literature review. Case Rep Otolaryngol. 2013; 2013:908327. Cervenka B, Villegas B, Sinha U. PMID: 24027649; PMCID: PMC3762137.
      View in: PubMed   Mentions: 3  
    51. Transoral robotic resection of oropharyngeal synovial sarcoma in a pediatric patient. Int J Pediatr Otorhinolaryngol. 2013 Jun; 77(6):1042-4. Kokot N, Mazhar K, O'Dell K, Huang N, Lin A, Sinha UK. PMID: 23639341.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    52. Uncommon cutaneous neoplasms of the head and neck. Facial Plast Surg Clin North Am. 2012 Nov; 20(4):483-91. Reinstadler DR, Sinha UK. PMID: 23084300.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    53. DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays. Oral Oncol. 2013 Feb; 49(2):93-101. Patel V, Martin D, Malhotra R, Marsh CA, Doçi CL, Veenstra TD, Nathan CA, Sinha UK, Singh B, Molinolo AA, Rusling JF, Gutkind JS. PMID: 23010602; PMCID: PMC3546158.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    54. α-Catulin marks the invasion front of squamous cell carcinoma and is important for tumor cell metastasis. Mol Cancer Res. 2012 Jul; 10(7):892-903. Cao C, Chen Y, Masood R, Sinha UK, Kobielak A. PMID: 22648798; PMCID: PMC3482427.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    55. Predictive value of bedside clinical signs and symptoms in early diagnosis of deep vein thrombosis in acutely ill medical patients with special reference to deep vein thrombosis prophylaxis. J Indian Med Assoc. 2012 Apr; 110(4):218-23. Mukhopadhyay P, Sinha U, Ghosh J, Philips CA. PMID: 23025220.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    56. Recent advances in biomarkers and potential targeted therapies in head and neck squamous cell carcinoma. ISRN Surg. 2012; 2012:715743. Yavrouian EJ, Sinha UK. PMID: 22523710; PMCID: PMC3302015.
      View in: PubMed   Mentions: 2  
    57. Prevalidation of salivary biomarkers for oral cancer detection. Cancer Epidemiol Biomarkers Prev. 2012 Apr; 21(4):664-72. Elashoff D, Zhou H, Reiss J, Wang J, Xiao H, Henson B, Hu S, Arellano M, Sinha U, Le A, Messadi D, Wang M, Nabili V, Lingen M, Morris D, Randolph T, Feng Z, Akin D, Kastratovic DA, Chia D, Abemayor E, Wong DT. PMID: 22301830; PMCID: PMC3319329.
      View in: PubMed   Mentions: 64     Fields:    Translation:Humans
    58. Gold nanorod-sphingosine kinase siRNA nanocomplexes: a novel therapeutic tool for potent radiosensitization of head and neck cancer. Integr Biol (Camb). 2012 Feb; 4(2):132-41. Masood R, Roy I, Zu S, Hochstim C, Yong KT, Law WC, Ding H, Sinha UK, Prasad PN. PMID: 22159374.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    59. Osteoradionecrosis. Oral Maxillofac Surg Clin North Am. 2011 Aug; 23(3):455-64. O'Dell K, Sinha U. PMID: 21798443.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    60. USC-HN2, a new model cell line for recurrent oral cavity squamous cell carcinoma with immunosuppressive characteristics. Oral Oncol. 2011 Sep; 47(9):810-7. Russell SM, Lechner MG, Gong L, Megiel C, Liebertz DJ, Masood R, Correa AJ, Han J, Puri RK, Sinha UK, Epstein AL. PMID: 21719345; PMCID: PMC3164740.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    61. The role of salivary cytokine biomarkers in tongue cancer invasion and mortality. Oral Oncol. 2011 Apr; 47(4):282-7. Korostoff A, Reder L, Masood R, Sinha UK. PMID: 21397550.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    62. Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. Head Neck. 2011 Feb; 33(2):178-88. Sinha UK, Schorn VJ, Hochstim C, Chinn SB, Zhu S, Masood R. PMID: 20848438.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    63. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia JG. PMID: 20069569; PMCID: PMC3122883.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    64. Establishment and characterization of a novel head and neck squamous cell carcinoma cell line USC-HN1. Head Neck Oncol. 2010 Feb 22; 2:5. Liebertz DJ, Lechner MG, Masood R, Sinha UK, Han J, Puri RK, Correa AJ, Epstein AL. PMID: 20175927; PMCID: PMC2841166.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    65. Invasion characteristics of oral tongue cancer: frequency of reporting and effect on survival in a population-based study. Cancer. 2009 Sep 01; 115(17):4010-20. Goodman M, Liu L, Ward K, Zhang J, Almon L, Su G, Berglund L, Chen A, Sinha UK, Young JL. PMID: 19551891.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansPHPublic Health
    66. Use of an oral sensory feedback device in the management of jaw-opening dystonia. Otolaryngol Head Neck Surg. 2009 Jul; 141(1):142-3. Verma SP, Sinha UK. PMID: 19559975.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    67. The significance of EphB4 and EphrinB2 expression and survival in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2008 Sep; 134(9):985-91. Yavrouian EJ, Sinha UK, Rice DH, Salam MT, Gill PS, Masood R. PMID: 18794445.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    68. Efficient multilevel brain tumor segmentation with integrated bayesian model classification. IEEE Trans Med Imaging. 2008 May; 27(5):629-40. Corso JJ, Sharon E, Dube S, El-Saden S, Sinha U, Yuille A. PMID: 18450536.
      View in: PubMed   Mentions: 45     Fields:    Translation:Humans
    69. Provider perceptions of patient psychosocial needs after orofacial injury. J Oral Maxillofac Surg. 2007 Aug; 65(8):1584-9. Zazzali JL, Marshall GN, Shetty V, Yamashita DD, Sinha UK, Rayburn NR. PMID: 17656287.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    70. The association between elevated EphB4 expression, smoking status, and advanced-stage disease in patients with head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Oct; 132(10):1053-9. Sinha UK, Mazhar K, Chinn SB, Dhillon VK, Liu L, Masood R, Rice DH, Gill PS. PMID: 17043250.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    71. EphB4 provides survival advantage to squamous cell carcinoma of the head and neck. Int J Cancer. 2006 Sep 15; 119(6):1236-48. Masood R, Kumar SR, Sinha UK, Crowe DL, Krasnoperov V, Reddy RK, Zozulya S, Singh J, Xia G, Broek D, Schönthal AH, Gill PS. PMID: 16615113.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    72. Circles of prominence: a new theory on facial aesthetics. Arch Facial Plast Surg. 2006 Jul-Aug; 8(4):263-7. Young PA, Sinha U, Rice DH, Stucker F. PMID: 16847173.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    73. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 2006 Apr 10; 24(11):1754-60. Li Y, Elashoff D, Oh M, Sinha U, St John MA, Zhou X, Abemayor E, Wong DT. PMID: 16505414.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    74. p53 apoptotic response to DNA damage dependent on bcl2 but not bax in head and neck squamous cell carcinoma lines. Head Neck. 2006 Jan; 28(1):15-23. Crowe DL, Sinha UK. PMID: 16302195.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    75. Sperm protein 17 expression defines 2 subsets of primary esthesioneuroblastoma. Hum Pathol. 2005 Dec; 36(12):1289-93. Bumm K, Grizzi F, Franceschini B, Koch M, Iro H, Wurm J, Ceva-Grimaldi G, Dimmler A, Cobos E, Dioguardi N, Sinha UK, Kast WM, Chiriva-Internati M. PMID: 16311122.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    76. Analysis of the brain-stem white-matter tracts with diffusion tensor imaging. Neuroradiology. 2005 Dec; 47(12):895-902. Salamon N, Sicotte N, Alger J, Shattuck D, Perlman S, Sinha U, Schultze-Haakh H, Salamon G. PMID: 16158279.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    77. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res. 2004 Dec 15; 10(24):8442-50. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. PMID: 15623624.
      View in: PubMed   Mentions: 197     Fields:    Translation:HumansCells
    78. Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Aug; 130(8):929-35. St John MA, Li Y, Zhou X, Denny P, Ho CM, Montemagno C, Shi W, Qi F, Wu B, Sinha U, Jordan R, Wolinsky L, Park NH, Liu H, Abemayor E, Wong DT. PMID: 15313862.
      View in: PubMed   Mentions: 155     Fields:    Translation:Humans
    79. Relationships between stem cells and cancer stem cells. Histol Histopathol. 2004 04; 19(2):505-9. Crowe DL, Parsa B, Sinha UK. PMID: 15024711.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    80. Functional outcomes following palatal reconstruction with a folded radial forearm free flap. Ear Nose Throat J. 2004 Jan; 83(1):45-8. Sinha UK, Young P, Hurvitz K, Crockett DM. PMID: 14986758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    81. Quantitative assessment of parallel acquisition techniques in diffusion tensor imaging at 3.0 Tesla. Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1072-5. Ardekani S, Sinha U. PMID: 17271868.
      View in: PubMed   Mentions: 1     Fields:    
    82. Expression of EphB4 in head and neck squamous cell carcinoma. Ear Nose Throat J. 2003 Nov; 82(11):866, 869-70, 887. Sinha UK, Kundra A, Scalia P, Smith DL, Parsa B, Masood R, Gill PS. PMID: 14661437.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    83. Pressure-Specifying Sensory Device: quantitative sensory measurement in the oral cavity and oropharynx of normal adults. Ear Nose Throat J. 2003 Sep; 82(9):682-4, 687-90. Sinha UK, Rhee J, Alcaraz N, Urken ML. PMID: 14569703.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    84. Overexpression of cell cycle regulatory proteins correlates with advanced tumor stage in head and neck squamous cell carcinomas. Int J Oncol. 2003 Jun; 22(6):1285-90. Nguyen DC, Parsa B, Close A, Magnusson B, Crowe DL, Sinha UK. PMID: 12738995.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    85. Effects of steel scalpel, ultrasonic scalpel, CO2 laser, and monopolar and bipolar electrosurgery on wound healing in guinea pig oral mucosa. Laryngoscope. 2003 Feb; 113(2):228-36. Sinha UK, Gallagher LA. PMID: 12567074.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    86. Use of AlloDerm implant to prevent frey syndrome after parotidectomy. Arch Facial Plast Surg. 2003 Jan-Feb; 5(1):109-12. Sinha UK, Saadat D, Doherty CM, Rice DH. PMID: 12533152.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCTClinical Trials
    87. Three-layer reconstruction for large defects of the anterior skull base. Laryngoscope. 2002 Mar; 112(3):424-7. Sinha UK, Johnson TE, Crockett D, Vadapalli S, Gruen P. PMID: 12148847.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    88. Use of AlloDerm for coverage of radial forearm free flap donor site. Laryngoscope. 2002 Feb; 112(2):230-4. Sinha UK, Shih C, Chang K, Rice DH. PMID: 11889375.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    89. Molecular pathology of head and neck cancer. Histol Histopathol. 2002; 17(3):909-14. Crowe DL, Hacia JG, Hsieh CL, Sinha UK, Rice H. PMID: 12168802.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    90. Reconstruction of pharyngeal defects using AlloDerm and sternocleidomastoid muscle flap. Laryngoscope. 2001 Nov; 111(11 Pt 1):1910-6. Sinha UK, Chang KE, Shih CW. PMID: 11801968.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    91. Frontotemporal reconstruction with hydroxyapatite cement and the radial forearm free flap. Arch Facial Plast Surg. 2001 Oct-Dec; 3(4):271-6. Sinha UK, Zim S, Maceri D. PMID: 11710865.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    92. Drop metastasis from sinonasal undifferentiated carcinoma: clinical implications. Spine (Phila Pa 1976). 2001 Jul 01; 26(13):1486-91. Ghosh S, Weiss M, Streeter O, Sinha U, Commins D, Chen TC. PMID: 11458156.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    93. Image content extraction: application to MR images of the brain. Radiographics. 2001 Mar-Apr; 21(2):535-47. Sinha U, Ton A, Yaghmai A, Taira RK, Kangarloo H. PMID: 11259717.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    94. Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol. 2000 Dec; 50(3):215-26. Gupta RK, Cloughesy TF, Sinha U, Garakian J, Lazareff J, Rubino G, Rubino L, Becker DP, Vinters HV, Alger JR. PMID: 11263501.
      View in: PubMed   Mentions: 114     Fields:    Translation:HumansCells
    95. Interactive software for generation and visualization of structured findings in radiology reports. AJR Am J Roentgenol. 2000 Sep; 175(3):609-12. Sinha U, Dai B, Johnson DB, Taira R, Dionisio J, Tashima G, Golamco M, Kangarloo H. PMID: 10954439.
      View in: PubMed   Mentions: 3     Fields:    
    96. Teleradiology as a foundation for an enterprise-wide health care delivery system. Radiographics. 2000 Jul-Aug; 20(4):1137-50. Dionisio JD, Taira RK, Sinha U, Johnson DB, Dai BY, Tashima GH, Blythe S, Johnson R, Kangarloo H. PMID: 10903702.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    97. Improving the quality of care through routine teleradiology consultation. Acad Radiol. 2000 Mar; 7(3):149-55. Kangarloo H, Valdez JA, Yao L, Chen S, Curran J, Goldman D, Sinha U, Dionisio JD, Taira R, Sayre J, Seeger L, Johnson R, Barbaric Z, Steckel R. PMID: 10730809.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    98. Evaluation of SNOMED3.5 in representing concepts in chest radiology reports: integration of a SNOMED mapper with a radiology reporting workstation. Proc AMIA Symp. 2000; 799-803. Sinha U, Yaghmai A, Thompson L, Dai B, Taira RK, Dionisio JD, Kangarloo H. PMID: 11079994; PMCID: PMC2243808.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    99. Endoscopic surgical management of sphenoid sinus disease. Laryngoscope. 1999 Oct; 109(10):1601-6. Rosen FS, Sinha UK, Rice DH. PMID: 10522928.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    100. Surgery of the salivary glands. Otolaryngol Clin North Am. 1999 Oct; 32(5):887-906. Sinha UK, Ng M. PMID: 10477794.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    101. Case-based explanation of non-case-based learning methods. Proc AMIA Symp. 1999; 212-5. Caruana R, Kangarloo H, Dionisio JD, Sinha U, Johnson D. PMID: 10566351; PMCID: PMC2232607.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    102. Initial experiences with building a health care infrastructure based on Java and object-oriented database technology. Proc AMIA Symp. 1999; 515-9. Dionisio JD, Sinha U, Dai B, Johnson DB, Taira RK. PMID: 10566412; PMCID: PMC2232573.
      View in: PubMed   Mentions:    Fields:    
    103. Process models for telehealth: an industrial approach to quality management of distant medical practice. Proc AMIA Symp. 1999; 545-9. Kangarloo H, Dionisio JD, Sinha U, Johnson D, Taira RK. PMID: 10566418; PMCID: PMC2232705.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    104. Inverse correlation between choline magnetic resonance spectroscopy signal intensity and the apparent diffusion coefficient in human glioma. Magn Reson Med. 1999 Jan; 41(1):2-7. Gupta RK, Sinha U, Cloughesy TF, Alger JR. PMID: 10025604.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    105. Oromandibular reconstruction using microvascular composite flaps: report of 210 cases. Arch Otolaryngol Head Neck Surg. 1998 Jan; 124(1):46-55. Urken ML, Buchbinder D, Costantino PD, Sinha U, Okay D, Lawson W, Biller HF. PMID: 9440780.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    106. Intraoperative mapping of sensate flaps. Electrophysiologic techniques and neurosomal boundaries. Arch Otolaryngol Head Neck Surg. 1997 Aug; 123(8):823-9. Rhee JS, Weisz DJ, Hirigoyen MB, Sinha U, Alcaraz N, Urken ML. PMID: 9260547.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    107. Use of a mechanical microvascular anastomotic device in head and neck free tissue transfer. Arch Otolaryngol Head Neck Surg. 1996 May; 122(5):529-32. Shindo ML, Costantino PD, Nalbone VP, Rice DH, Sinha UK. PMID: 8615971.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    108. Temporal bone findings in Alzheimer's disease. Laryngoscope. 1996 Jan; 106(1 Pt 1):1-5. Sinha UK, Saadat D, Linthicum FH, Hollen KM, Miller CA. PMID: 8544613.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    109. Sensory recovery in noninnervated free flaps for head and neck reconstruction. Laryngoscope. 1995 Dec; 105(12 Pt 1):1290-3. Shindo ML, Sinha UK, Rice DH. PMID: 8523979.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    110. Safety of thyroidectomy in residency: a review of 186 consecutive cases. Laryngoscope. 1995 Nov; 105(11):1173-5. Shindo ML, Sinha UK, Rice DH. PMID: 7475870.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    111. Dynamic properties of the posterior cricoarytenoid muscle. Ann Otol Rhinol Laryngol. 1994 Dec; 103(12):937-44. Cooper DS, Shindo M, Sinha U, Hast MH, Rice DH. PMID: 7993005.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    112. MR imaging signal response to sustained stimulation in human visual cortex. J Magn Reson Imaging. 1994 Jul-Aug; 4(4):537-43. Hathout GM, Kirlew KA, So GJ, Hamilton DR, Zhang JX, Sinha U, Sinha S, Sayre J, Gozal D, Harper RM, et al. PMID: 7949678.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    113. Abnormal neuritic architecture identified by Di-I in Pick's disease. J Neuropathol Exp Neurol. 1993 Jul; 52(4):411-8. Sinha UK, Hollen KM, Miller CA. PMID: 8355029.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    114. Auditory system degeneration in Alzheimer's disease. Neurology. 1993 Apr; 43(4):779-85. Sinha UK, Hollen KM, Rodriguez R, Miller CA. PMID: 8469340.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansCells
    115. Magnetic resonance image synthesis from analytic solutions of spin-echo and radio frequency-spoiled gradient-echo images. Invest Radiol. 1992 Oct; 27(10):856-64. Sinha S, Sinha U, Kangarloo H, Huang HK. PMID: 1399443.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    116. Radionecrosis secondary to interstitial brachytherapy: correlation of magnetic resonance imaging and histopathology. Neurosurgery. 1992 Aug; 31(2):336-43. Oppenheimer JH, Levy ML, Sinha U, el-Kadi H, Apuzzo ML, Luxton G, Petrovich Z, Zee CS, Miller CA. PMID: 1513439.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansPHPublic Health
    117. A PACS-based interactive teaching module for radiologic sciences. AJR Am J Roentgenol. 1992 Jul; 159(1):199-205. Sinha S, Sinha U, Kangarloo H, Huang HK. PMID: 1609698.
      View in: PubMed   Mentions: 5     Fields:    
    118. Anatomical relationships of the cochlear nuclei and the pontobulbar body: possible significance for neuroprosthesis placement. Laryngoscope. 1987 Sep; 97(9):1009-11. Terr LI, Sinha UK, House WF. PMID: 3626721.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    119. Computer-aided three-dimensional reconstruction of the cochlear nerve root. Arch Otolaryngol Head Neck Surg. 1987 Jun; 113(6):651-5. Sinha UK, Terr LI, Galey FR, Linthicum FH. PMID: 3566949.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    120. Fractures of the upper-third of the tibial shaft. Int Surg. 1983 Jul-Sep; 68(3):267-70. Prasad P, Sinha UK. PMID: 6662643.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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