Joseph G Hacia, PhD

TitleAssociate Professor of Biochemistry & Molecular Medicine
InstitutionUniversity of Southern California
DepartmentBiochemistry and Molecular Biology
AddressCSC 261 2250 Alcazar Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 3030
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    Other Positions
    TitleVice Chair For Medical Education

    Collapse Biography 
    Collapse Awards and Honors
    1989  - 1995Howard Hughes Medical Institute Predoctoral Fellow
    2000American Society of Human Genetics (ASHG) Postdoctoral Translational Research Award
    2002V Foundation Scholar
    2004  - 2010Editorial Board of Genome Research
    2008  - 2013Member of NIH Comparative Genomics Study Section
    2008Editorial Board Nucleic Acids Research
    2010Chaired Session at ASHG meeting on Early Diagnosis and Treatment of CNS-based Metabolic Disorders
    2010Editorial Board BMC Genomics
    2010Member, Scientific Advisory Board of the Global Foundation for Peroxisomal Disorders
    2012External Reviewer, Institute of Medicine Review of California Institute for Regenerative Medicine
    2013Year 1 USC Medical Teaching Award
    2014Chaired Session at ASHG meeting on Targeted Drug Therapies for Progressive Genetic Disorders
    2015Year 2 USC Medical Teaching Award
    2015Member of X-linked Adrenoleukodystrophy (ALD) Connect Workgroup on Therapy Review
    2015Member of Chemical Gene & Cell Therapy Committee of the American Society of Gene & Cell Therapy
    2016Editorial Board BMC Medical Genomics
    2016Year 1 USC Medical Teaching Award
    2016Year 1 Outstanding Course Award for USC Medical Teaching
    2016Master Teacher of the Keck School of Medicine of USC
    2016Member, Scientific Advisory Board of RhizoKids International
    2016Chaired Session at ‘Leukodystrophies Conference’ in Baltimore, Maryland
    2017Member, Medical Advisory Board of RhizoKids International
    2017Co-organized Development of Therapies for Peroxisome Biogenesis Disorders Conference; Washington, DC
    2017Award of Recognition for Excellence in Scientific Community Building for PBD Research by the GFPD

    Collapse Overview 
    Collapse Overview
    Joe Hacia, an Associate Professor of Biochemistry and Molecular Medicine, is a medical geneticist who obtained his undergraduate training at Rutgers University and graduate training at the California Institute of Technology. Prior to joining the USC faculty, he obtained his post-doctoral training at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

    The Hacia laboratory focuses on developing therapies for genetic disorders caused by impaired peroxisome assembly, structure, and function. His group focuses on peroxisome biogenesis disorders (PBDs), which include Zellweger spectrum disorder (PBD-ZSD) and rhizomelic chondrodysplasia punctata (RCDP). Affected children frequently show progressive loss of vision and hearing, brain and liver dysfunction, craniofacial dysmorphism, and enamel defects.

    The Hacia laboratory is involved in screening of large chemical libraries for candidate small molecule therapies as well as gene therapy and cell transplantation therapy projects. As part of these efforts, they developed patient-specific induced pluripotent stem cells (iPSCs) models of peroxisomal disorders. By working closely with physician-scientists and patient advocacy groups, the Global Foundation for Peroxisomal Disorders (GFPD) (http://www.thegfpd.org/) and RhizoKids International (http://www.rhizokids.com/), they seek to translate their research into improved treatments in the near future.

    The Hacia laboratory has used comparative genomic and lipidomic approaches to uncover evidence that peroxisomal metabolic activities has been strongly influenced by diet in primate lineages. They wish to use the knowledge gained from these projects to benefit the health of captive non-human primates and people with peroxisomal disorders.

    Research Interests: medical genetics, molecular therapeutics
    Diseases Models: cultured fibroblasts, induced pluripotent stem cells, genome-edited cell lines, genetically engineered mice
    Consortia: Global Foundation for Peroxisomal Disorders and RhizoKids International

    Collapse Research 
    Collapse Research Activities and Funding
    Development of Targeted Therapies for Peroxisome Biogenesis Disorders: Current and future prospects
    NIH/NINDS R13NS100379Sep 30, 2016 - Aug 31, 2017
    Role: Principal Investigator
    NINDS Exploratory/Developmental Projects in Translational Research
    NIH/NINDS R21NS064572Sep 15, 2008 - Aug 31, 2011
    Role: Principal Investigator
    Mutational Analysis of Peroxisome Biogenesis Disorders
    NIH/NICHD R21HD050277Aug 3, 2005 - Jul 31, 2008
    Role: Principal Investigator
    Comparative Genomics of Peroxisomal Lipid Metabolism
    NIH/NIGMS R01GM072477Apr 1, 2005 - Mar 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Featured Videos
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Curiel J, Steinberg SJ, Bright S, Snowden A, Moser AB, Eichler F, Dubbs HA, Hacia J, Ely JJ, Bezner J, Gean A, Vanderver A. X-linked adrenoleukodystrophy in a chimpanzee due to an ABCD1 mutation reported in multiple unrelated humans. Mol Genet Metab. 2017 Nov; 122(3):130-133. PMID: 28919002.
      View in: PubMed
    2. Yin K, Lin W, Guo J, Sugiyama T, Snead ML, Hacia J, Paine ML. MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies. Sci Rep. 2017 Mar 13; 7:44118. PMID: 28287144.
      View in: PubMed
    3. Shahabi A, Lewinger JP, Ren J, April C, Sherrod AE, Hacia J, Daneshmand S, Gill I, Pinski JK, Fan JB, Stern MC. Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients. Prostate. 2016 Oct; 76(14):1239-56. PMID: 27272349.
      View in: PubMed
    4. Braverman NE, Raymond GV, Rizzo WB, Moser AB, Wilkinson ME, Stone EM, Steinberg SJ, Wangler MF, Rush ET, Hacia J, Bose M. Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines. Mol Genet Metab. 2016 Mar; 117(3):313-21. PMID: 26750748.
      View in: PubMed
    5. Ramaswamy K, Yik WY, Wang XM, Oliphant EN, Lu W, Shibata D, Ryder OA, Hacia J. Derivation of induced pluripotent stem cells from orangutan skin fibroblasts. BMC Res Notes. 2015 Oct 16; 8:577. PMID: 26475477; PMCID: PMC4609060.
    6. Wang XM, Yik WY, Zhang P, Lu W, Huang N, Kim BR, Shibata D, Zitting M, Chow RH, Moser AB, Steinberg SJ, Hacia J. Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities. Stem Cell Res Ther. 2015 Aug 29; 6:158. PMID: 26319495; PMCID: PMC4553005.
    7. Yin K, Hacia J, Zhong Z, Paine ML. Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics. 2014 Nov 19; 15:998. PMID: 25406666; PMCID: PMC4254193.
    8. Hiebler S, Masuda T, Hacia J, Moser AB, Faust PL, Liu A, Chowdhury N, Huang N, Lauer A, Bennett J, Watkins PA, Zack DJ, Braverman NE, Raymond GV, Steinberg SJ. The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab. 2014 Apr; 111(4):522-532. PMID: 24503136; PMCID: PMC4901203.
    9. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia J. Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr; 114(4):796-807. PMID: 23060211; PMCID: PMC3777336.
    10. Moser AB, Hey J, Dranchak PK, Karaman MW, Zhao J, Cox LA, Ryder OA, Hacia J. Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells. Lipids Health Dis. 2013 Feb 04; 12:10. PMID: 23379307; PMCID: PMC3571895.
    11. Wang XM, Yik WY, Zhang P, Lu W, Dranchak PK, Shibata D, Steinberg SJ, Hacia J. The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis. Stem Cell Res Ther. 2012 Oct 04; 3(5):39. PMID: 23036268; PMCID: PMC3580430.
    12. Levesque S, Morin C, Guay SP, Villeneuve J, Marquis P, Yik WY, Jiralerspong S, Bouchard L, Steinberg S, Hacia J, Dewar K, Braverman NE. A founder mutation in the PEX6 gene is responsible for increased incidence of Zellweger syndrome in a French Canadian population. BMC Med Genet. 2012 Aug 15; 13:72. PMID: 22894767; PMCID: PMC3483250.
    13. Lacruz RS, Hacia J, Bromage TG, Boyde A, Lei Y, Xu Y, Miller JD, Paine ML, Snead ML. The circadian clock modulates enamel development. J Biol Rhythms. 2012 Jun; 27(3):237-45. PMID: 22653892; PMCID: PMC3511783.
    14. Lacruz RS, Smith CE, Bringas P, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia J, Hubbard MJ, Paine ML. Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol. 2012 May; 227(5):2264-75. PMID: 21809343; PMCID: PMC3243804.
    15. Han D, Zhao H, Parada C, Hacia J, Bringas P, Chai Y. A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. PMID: 22438570; PMCID: PMC3317969.
    16. Iwata J, Hacia J, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. PMID: 22326956; PMCID: PMC3287237.
    17. Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia J, Paine ML. Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci. 2011 Dec; 119 Suppl 1:149-57. PMID: 22243241; PMCID: PMC3286129.
    18. Iwata J, Tung L, Urata M, Hacia J, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. PMID: 22123828; PMCID: PMC3268397.
    19. Moser AB, Steinberg SJ, Watkins PA, Moser HW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia J. Human and great ape red blood cells differ in plasmalogen levels and composition. Lipids Health Dis. 2011 Jun 17; 10:101. PMID: 21679470; PMCID: PMC3129581.
    20. Dranchak PK, Di Pietro E, Snowden A, Oesch N, Braverman NE, Steinberg SJ, Hacia J. Nonsense suppressor therapies rescue peroxisome lipid metabolism and assembly in cells from patients with specific PEX gene mutations. J Cell Biochem. 2011 May; 112(5):1250-8. PMID: 21465523; PMCID: PMC3136445.
    21. Lacruz RS, Lakshminarayanan R, Bromley KM, Hacia J, Bromage TG, Snead ML, Moradian-Oldak J, Paine ML. Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin. PLoS One. 2011 Mar 18; 6(3):e18028. PMID: 21437261; PMCID: PMC3060920.
    22. Watkins PA, Moser AB, Toomer CB, Steinberg SJ, Moser HW, Karaman MW, Ramaswamy K, Siegmund KD, Lee DR, Ely JJ, Ryder OA, Hacia J. Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions. BMC Physiol. 2010 Oct 08; 10:19. PMID: 20932325; PMCID: PMC2964658.
    23. Wang XM, Greiner TC, Bibikova M, Pike BL, Siegmund KD, Sinha UK, Müschen M, Jaeger EB, Weisenburger DD, Chan WC, Shibata D, Fan JB, Hacia J. Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations. J Cell Biochem. 2010 Mar 01; 109(4):818-27. PMID: 20069569; PMCID: PMC3122883.
    24. Toleno DM, Renaud G, Wolfsberg TG, Islam M, Wildman DE, Siegmund KD, Hacia J. Development and evaluation of new mask protocols for gene expression profiling in humans and chimpanzees. BMC Bioinformatics. 2009 Mar 05; 10:77. PMID: 19265541; PMCID: PMC2660304.
    25. Yik WY, Steinberg SJ, Moser AB, Moser HW, Hacia J. Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders. Hum Mutat. 2009 Mar; 30(3):E467-80. PMID: 19105186; PMCID: PMC2649967.
    26. Magda D, Lecane P, Prescott J, Thiemann P, Ma X, Dranchak PK, Toleno DM, Ramaswamy K, Siegmund KD, Hacia J. mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft. BMC Genomics. 2008 Nov 03; 9:521. PMID: 18980691; PMCID: PMC2612029.
    27. Magda D, Lecane P, Wang Z, Hu W, Thiemann P, Ma X, Dranchak PK, Wang X, Lynch V, Wei W, Csokai V, Hacia J, Sessler JL. Synthesis and anticancer properties of water-soluble zinc ionophores. Cancer Res. 2008 Jul 01; 68(13):5318-25. PMID: 18593933; PMCID: PMC3033660.
    28. Hacia J, Lee CC, Jimenez DF, Karaman MW, Ho VV, Siegmund KD, Tarantal AF. Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells. J Cell Biochem. 2008 Mar 01; 103(4):1198-210. PMID: 17685434.
      View in: PubMed
    29. Ku TK, Nguyen DC, Karaman M, Gill P, Hacia J, Crowe DL. Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer. Mol Cancer Res. 2007 Apr; 5(4):351-62. PMID: 17426250.
      View in: PubMed
    30. Wang Z, Lecane PS, Thiemann P, Fan Q, Cortez C, Ma X, Tonev D, Miles D, Naumovski L, Miller RA, Magda D, Cho DG, Sessler JL, Pike BL, Yeligar SM, Karaman MW, Hacia J. Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression. Mol Cancer. 2007 Jan 19; 6:9. PMID: 17233922; PMCID: PMC1784109.
    31. Pike BL, Groshen S, Hsu YH, Shai RM, Wang X, Holtan N, Futscher BW, Hacia J. Comparisons of PCR-based genome amplification systems using CpG island microarrays. Hum Mutat. 2006 Jun; 27(6):589-96. PMID: 16652338.
      View in: PubMed
    32. Greiner TC, Dasgupta C, Ho VV, Weisenburger DD, Smith LM, Lynch JC, Vose JM, Fu K, Armitage JO, Braziel RM, Campo E, Delabie J, Gascoyne RD, Jaffe ES, Muller-Hermelink HK, Ott G, Rosenwald A, Staudt LM, Im MY, Karaman MW, Pike BL, Chan WC, Hacia J. Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma. Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2352-7. PMID: 16461462; PMCID: PMC1413716.
    33. Lecane PS, Karaman MW, Sirisawad M, Naumovski L, Miller RA, Hacia J, Magda D. Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15; 65(24):11676-88. PMID: 16357179.
      View in: PubMed
    34. Magda D, Lecane P, Miller RA, Lepp C, Miles D, Mesfin M, Biaglow JE, Ho VV, Chawannakul D, Nagpal S, Karaman MW, Hacia J. Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 01; 65(9):3837-45. PMID: 15867382.
      View in: PubMed
    35. Smith E, Meyerrose TE, Kohler T, Namdar-Attar M, Bab N, Lahat O, Noh T, Li J, Karaman MW, Hacia J, Chen TT, Nolta JA, Müller R, Bab I, Frenkel B. Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo. Nucleic Acids Res. 2005; 33(4):1298-308. PMID: 15741183; PMCID: PMC552952.
    36. Karaman MW, Groshen S, Lee CC, Pike BL, Hacia J. Comparisons of substitution, insertion and deletion probes for resequencing and mutational analysis using oligonucleotide microarrays. Nucleic Acids Res. 2005 Feb 18; 33(3):e33. PMID: 15722479; PMCID: PMC549431.
    37. Leclerc N, Luppen CA, Ho VV, Nagpal S, Hacia J, Smith E, Frenkel B. Gene expression profiling of glucocorticoid-inhibited osteoblasts. J Mol Endocrinol. 2004 Aug; 33(1):175-93. PMID: 15291752.
      View in: PubMed
    38. Lipkin SM, Rozek LS, Rennert G, Yang W, Chen PC, Hacia J, Hunt N, Shin B, Fodor S, Kokoris M, Greenson JK, Fearon E, Lynch H, Collins F, Gruber SB. The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer. Nat Genet. 2004 Jul; 36(7):694-9. PMID: 15184898.
      View in: PubMed
    39. Nagpal S, Karaman MW, Timmerman MM, Ho VV, Pike BL, Hacia J. Improving the sensitivity and specificity of gene expression analysis in highly related organisms through the use of electronic masks. Nucleic Acids Res. 2004 Mar 18; 32(5):e51. PMID: 15031318; PMCID: PMC390348.
    40. Karaman MW, Houck ML, Chemnick LG, Nagpal S, Chawannakul D, Sudano D, Pike BL, Ho VV, Ryder OA, Hacia J. Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts. Genome Res. 2003 Jul; 13(7):1619-30. PMID: 12840040; PMCID: PMC403735.
    41. Fang NY, Greiner TC, Weisenburger DD, Chan WC, Vose JM, Smith LM, Armitage JO, Mayer RA, Pike BL, Collins FS, Hacia J. Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5372-7. PMID: 12697903; PMCID: PMC154352.