Yang Chai, DMD, PhD, DDS

TitleProfessor and Associate Dean, Research and Director, Center For Craniofacial Molecular Biology
InstitutionUniversity of Southern California
DepartmentBiomedical Engineering
AddressCSA 148
Health Sciences Campus
Los Angeles CA 90089-9062
Phone+1 323 442 3480
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    Collapse Biography 
    Collapse Awards and Honors
    NIDCR, NIH2013Chair of the Board of Scientific Counselors
    Craniofacial Biology Research Award2011IADR Distinguished Scientist Award
    Journal of Bone and Mineral Research2010  - 2014Editorial Board
    NIH2010 NIH MERIT Award
    2010American Association for the Advancement of Sciences (AAAS) Elected Fellow
    NIDCR, NIH2008  - 2012Member of the Board of Scientific Counselors
    JBMR2007  - 2014Editorial Board DEVELOPMENTAL BIOLOGY
    The Chinese Journal of Dental Research2006  - 2014Editorial Board
    2004  - 2008Regular member of SBDD study section CSR NIH
    2004Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
    2006Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
    2002  - 2014NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK
    University of Southern California2001  - 2003Award of Excellence in Teaching
    University of Southern California1997James H. Zumberge Faculty Research and Innovation Award
    University of Southern California2007James H. Zumberge Faculty Research and Innovation Award
    University of Southern California1997Annual Excellence in Teaching Award
    1996OKU Scholarship award for outstanding academic performance
    1996Special Recognition by the Dean for outstanding service and contribution to the University of Southe
    University of Southern California, School of Dentistry1995Annual Teaching Award
    University of Southern California, (GPA 4.0)1991PHI KAPPA PHI, All-University Honor Society
    University of Southern California1990Certificate for Outstanding Academic Achievement

    Collapse Overview 
    Collapse Overview
    Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

    Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

    Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

    Collapse Research 
    Collapse Research Activities and Funding
    Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH/NIDCR U24DE026914Mar 1, 2017 - Feb 29, 2020
    Role: Co-Principal Investigator
    Molecular and Cellular Basis of Craniosynostosis
    NIH/NIDCR R01DE026339Jul 1, 2016 - Mar 31, 2021
    Role: Co-Principal Investigator
    NIH/NIDCR R01DE025221May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    NIH/NIDCR R34DE025575Sep 1, 2015 - Aug 31, 2016
    Role: Principal Investigator
    NIH/NIDCR U01DE024421May 12, 2014 - Apr 30, 2019
    Role: Principal Investigator
    NIH/NIDCR R01DE022503Jul 19, 2012 - Jun 30, 2017
    Role: Principal Investigator
    NIH/NIDCR U01DE020065Sep 21, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Interdisciplinary New Faculty Recruitment in Craniofacial Development
    NIH/NIDCR P30DE020750Sep 17, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Molecular Regulatory Mechanism of Calvarial Morphogenesis
    NIH/NIDCR R01DE017007Sep 1, 2005 - Aug 31, 2012
    Role: Principal Investigator
    NIH/NIDCR R13DE015783Jan 1, 2004 - Dec 31, 2008
    Role: Co-Principal Investigator
    NIH/NIDCR R01DE014078Apr 1, 2001 - Jun 30, 2014
    Role: Principal Investigator
    NIH/NIDCR R37DE012711Jan 1, 1999 - Jun 30, 2019
    Role: Principal Investigator
    NIH/NIDCR R01DE012711Jan 1, 1999 - May 31, 2010
    Role: Principal Investigator

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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang H, Han X, Tian Y, Li Y, Yang K, Hao H, Chai Y, Xu X. Process analysis of anaerobic fermentation of Phragmites australis straw and cow dung exposing to elevated chromium (VI) concentrations. J Environ Manage. 2018 Jul 23; 224:414-424. PMID: 30075309.
      View in: PubMed
    2. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 Jul 05; 23(1):147. PMID: 29979989.
      View in: PubMed
    3. Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y. Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 Jul 04. PMID: 29981310.
      View in: PubMed
    4. An Z, Akily B, Sabalic M, Zong G, Chai Y, Sharpe PT. Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor. Cell Rep. 2018 Jun 05; 23(10):3102-3111. PMID: 29874594.
      View in: PubMed
    5. Xing M, Zhou Y, Dong C, Cai L, Zeng L, Shen B, Pan L, Dong C, Chai Y, Zhang J, Yin Y. Modulation of the Reduction Potential of TiO2- x by Fluorination for Efficient and Selective CH4 Generation from CO2 Photoreduction. Nano Lett. 2018 May 02. PMID: 29701060.
      View in: PubMed
    6. Gou Y, Li J, Wu J, Gupta R, Cho I, Ho TV, Chai Y, Merrill A, Wang J, Xu J. Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 May 01. PMID: 29727702.
      View in: PubMed
    7. Li SK, Liu ZT, Li JY, Chen AY, Chai YQ, Yuan R, Zhuo Y. Enzyme-free Target Recycling and Double-Output Amplification System for Electrochemiluminescent Assay of Mucin 1 with MoS2 Nanoflowers as Co-reaction Accelerator. ACS Appl Mater Interfaces. 2018 May 02; 10(17):14483-14490. PMID: 29664278.
      View in: PubMed
    8. Bobarnac Dogaru GL, Juneja SC, Shokrani A, Hui RY, Chai Y, Pepper JP. The role of Hedgehog-responsive fibroblasts in facial nerve regeneration. Exp Neurol. 2018 May; 303:72-79. PMID: 29337143.
      View in: PubMed
    9. Sugii H, Grimaldi A, Li J, Parada C, Vu-Ho T, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y. The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development. 2017 11 01; 144(21):4037-4045. PMID: 28982687.
      View in: PubMed
    10. Zeng WJ, Liao N, Lei YM, Zhao J, Chai YQ, Yuan R, Zhuo Y. Hemin as electrochemically regenerable co-reaction accelerator for construction of an ultrasensitive PTCA-based electrochemiluminescent aptasensor. Biosens Bioelectron. 2018 Feb 15; 100:490-496. PMID: 28965054.
      View in: PubMed
    11. He D, Qiao J, Zhang L, Wang J, Lan T, Qian J, Li Y, Shi Y, Chai Y, Lan W, Ono LK, Qi Y, Xu JB, Ji W, Wang X. Ultrahigh mobility and efficient charge injection in monolayer organic thin-film transistors on boron nitride. Sci Adv. 2017 Sep; 3(9):e1701186. PMID: 28913429.
      View in: PubMed
    12. Zhao J, Liang WB, Lei YM, Ou YX, Chai YQ, Yuan R, Zhuo Y. An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. Biosens Bioelectron. 2017 Dec 15; 98:317-324. PMID: 28697444.
      View in: PubMed
    13. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 Jun 20; 7(1):3876. PMID: 28634413.
      View in: PubMed
    14. Ma S, Zeng L, Tao L, Tang CY, Yuan H, Long H, Cheng PK, Chai Y, Chen C, Fung KH, Zhang X, Lau SP, Tsang YH. Enhanced Photocatalytic Activity of WS2 Film by Laser Drilling to Produce Porous WS2/WO3 Heterostructure. Sci Rep. 2017 Jun 09; 7(1):3125. PMID: 28600560.
      View in: PubMed
    15. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 07 15; 144(14):2560-2569. PMID: 28576771.
      View in: PubMed
    16. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W, Sanchez-Lara PA, Chai Y. Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 03 01; 26(5):860-872. PMID: 28069795.
      View in: PubMed
    17. Li J, Parada C, Chai Y. Cellular and molecular mechanisms of tooth root development. Development. 2017 02 01; 144(3):374-384. PMID: 28143844.
      View in: PubMed
    18. Gao YL, Lu B, Zhai JH, Liu YC, Qi HX, Yao Y, Chai YF, Shou ST. The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression. Mediators Inflamm. 2017; 2017:4024672. PMID: 28210072.
      View in: PubMed
    19. Gao YL, Yu MM, Shou ST, Yao Y, Liu YC, Wang LJ, Lu B, Chai YF. Tuftsin prevents the negative immunoregulation of neuropilin-1highCD4+CD25+Regulatory T cells and improves survival rate in septic mice. Oncotarget. 2016 Dec 06; 7(49):81791-81805. PMID: 27835904.
      View in: PubMed
    20. Long M, Zhang T, Chai Y, Ng CF, Mak TC, Xu J, Yan K. Nonstoichiometric acid-base reaction as reliable synthetic route to highly stable CH3NH3PbI3 perovskite film. Nat Commun. 2016 Nov 15; 7:13503. PMID: 27843140.
      View in: PubMed
    21. Park S, Zhao H, Urata M, Chai Y. Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 12 01; 25(23):1801-1807. PMID: 27762665.
      View in: PubMed
    22. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 11 15; 143(22):4115-4126. PMID: 27660324.
      View in: PubMed
    23. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 Sep; 54(9):490-6. PMID: 27381449; PMCID: PMC5021577 [Available on 09/01/17].
    24. Zhao J, Lei YM, Chai YQ, Yuan R, Zhuo Y. Novel electrochemiluminescence of perylene derivative and its application to mercury ion detection based on a dual amplification strategy. Biosens Bioelectron. 2016 Dec 15; 86:720-727. PMID: 27474970.
      View in: PubMed
    25. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 07 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338.
    26. Gao YL, Chai YF, Qi AL, Yao Y, Liu YC, Dong N, Wang LJ, Yao YM. Neuropilin-1highCD4?CD25? Regulatory T Cells Exhibit Primary Negative Immunoregulation in Sepsis. Mediators Inflamm. 2016; 2016:7132158. PMID: 27239104; PMCID: PMC4863118.
    27. Burg ML, Chai Y, Yao CA, Magee W, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016; 7:67. PMID: 26973535; PMCID: PMC4771933.
    28. Grimaldi A, Parada C, Chai Y. A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015; 10(12):e0145018. PMID: 26671681; PMCID: PMC4687642.
    29. Gao YL, Chai YF, Dong N, Han S, Zhu XM, Zhang QH, Yao YM. Tuftsin-derived T-peptide prevents cellular immunosuppression and improves survival rate in septic mice. Sci Rep. 2015 Nov 18; 5:16725. PMID: 26577833; PMCID: PMC4649719.
    30. Parada C, Chai Y. Mandible and Tongue Development. Curr Top Dev Biol. 2015; 115:31-58. PMID: 26589920; PMCID: PMC4869709.
    31. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01; 142(21):3734-45. PMID: 26395480; PMCID: PMC4647211 [Available on 11/01/16].
    32. Liu Y, Feng J, Li J, Zhao H, Ho TV, Chai Y. An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 01; 142(19):3374-82. PMID: 26293299; PMCID: PMC4631759 [Available on 10/01/16].
    33. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang S, Chai Y. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell. 2015 Apr 20; 33(2):125-35. PMID: 25865348; PMCID: PMC4406846.
    34. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr; 17(4):386-96. PMID: 25799059; PMCID: PMC4380556.
    35. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17; 459(4):706-12. PMID: 25770424.
      View in: PubMed
    36. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15; 400(2):180-90. PMID: 25722190; PMCID: PMC4385433.
    37. Shen WJ, Zhuo Y, Chai YQ, Yang ZH, Han J, Yuan R. Enzyme-free electrochemical immunosensor based on host-guest nanonets catalyzing amplification for procalcitonin detection. ACS Appl Mater Interfaces. 2015 Feb 25; 7(7):4127-34. PMID: 25629216.
      View in: PubMed
    38. Han J, Zhuo Y, Chai YQ, Xiang Y, Yuan R. New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal Chem. 2015 Feb 03; 87(3):1669-75. PMID: 25547661.
      View in: PubMed
    39. Chai Y. Preface. Curr Top Dev Biol. 2015; 115:xix-xxi. PMID: 26589940.
      View in: PubMed
    40. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep; 42(9):637-44. PMID: 25265730.
      View in: PubMed
    41. Han A, Zhao H, Li J, Pelikan R, Chai Y. ALK5-mediated transforming growth factor ß signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug; 34(16):3120-31. PMID: 24912677; PMCID: PMC4135603.
    42. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. PMID: 24506883; PMCID: PMC3951379.
    43. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb; 141(4):909-17. PMID: 24496627; PMCID: PMC3912833.
    44. Zhang S, Tang C, Zhao Q, Li J, Yang L, Qie L, Fan X, Li L, Zhang N, Zhao M, Liu X, Chai Y, Zhang X, Wang H, Li Y, Li W, Zhi H, Jia G, Diao X. Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L.) P. Beauv]. BMC Genomics. 2014 Jan 28; 15:78. PMID: 24472631; PMCID: PMC3930901.
    45. Zhuo Y, Liao N, Chai YQ, Gui GF, Zhao M, Han J, Xiang Y, Yuan R. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal Chem. 2014 Jan 21; 86(2):1053-60. PMID: 24328308.
      View in: PubMed
    46. Jia G, Shi S, Wang C, Niu Z, Chai Y, Zhi H, Diao X. Molecular diversity and population structure of Chinese green foxtail [Setaria viridis (L.) Beauv.] revealed by microsatellite analysis. J Exp Bot. 2013 Sep; 64(12):3645-56. PMID: 23956411; PMCID: PMC3745726.
    47. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 01; 23(1):182-93. PMID: 23975680; PMCID: PMC3857953.
    48. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. Noncanonical transforming growth factor ß (TGFß) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11; 288(41):29760-70. PMID: 23950180; PMCID: PMC3795273.
    49. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 2013 Sep 27; 113(8):e76-86. PMID: 23817199; PMCID: PMC3837448.
    50. Parada C, Li J, Iwata J, Suzuki A, Chai Y. CTGF mediates Smad-dependent transforming growth factor ß signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013 Sep; 33(17):3482-93. PMID: 23816882; PMCID: PMC3753855.
    51. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One. 2013; 8(4):e61653. PMID: 23613893; PMCID: PMC3629100.
    52. Gui G, Zhuo Y, Chai YQ, Liao N, Zhao M, Han J, Zhu Q, Yuan R, Xiang Y. Supersandwich-type electrochemiluminescenct aptasensor based on Ru(phen)3(2+) functionalized hollow gold nanoparticles as signal-amplifying tags. Biosens Bioelectron. 2013 Sep 15; 47:524-9. PMID: 23643946.
      View in: PubMed
    53. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr; 114(4):796-807. PMID: 23060211; PMCID: PMC3777336.
    54. Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12; 288(15):10440-50. PMID: 23460641; PMCID: PMC3624426.
    55. Liao N, Zhuo Y, Chai YQ, Xiang Y, Han J, Yuan R. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron. 2013 Jul 15; 45:189-94. PMID: 23500362.
      View in: PubMed
    56. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar; 140(6):1220-30. PMID: 23406900; PMCID: PMC3585659.
    57. Huang XF, Chai Y. Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012 Dec; 4(4):177-81. PMID: 23222990; PMCID: PMC3633063.
    58. Wang C, Jia G, Zhi H, Niu Z, Chai Y, Li W, Wang Y, Li H, Lu P, Zhao B, Diao X. Genetic diversity and population structure of Chinese foxtail millet [Setaria italica (L.) Beauv.] landraces. G3 (Bethesda). 2012 Jul; 2(7):769-77. PMID: 22870400; PMCID: PMC3385983.
    59. Parada C, Chai Y. Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012; 16:60-70. PMID: 22759670; PMCID: PMC3661199.
    60. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May; 40(5):433-6, 438-9. PMID: 22685951.
      View in: PubMed
    61. Han D, Zhao H, Parada C, Hacia JG, Bringas P, Chai Y. A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. PMID: 22438570; PMCID: PMC3317969.
    62. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. PMID: 22326956; PMCID: PMC3287237.
    63. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. PMID: 22123828; PMCID: PMC3268397.
    64. Han J, Zhuo Y, Chai YQ, Yuan YL, Yuan R. Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase. Biosens Bioelectron. 2012 Jan 15; 31(1):399-405. PMID: 22169815.
      View in: PubMed
    65. Hung Y, Huang X, Chai Y. Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May; 39(5):321-4. PMID: 21721476.
      View in: PubMed
    66. Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, Wang S, Chai Y. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May; 138(10):1977-89. PMID: 21490069; PMCID: PMC3082303.
    67. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441; PMCID: PMC3440302.
    68. Han J, Zhuo Y, Chai YQ, Mao L, Yuan YL, Yuan R. Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen. Talanta. 2011 Jul 15; 85(1):130-5. PMID: 21645681.
      View in: PubMed
    69. Zhao H, Li S, Han D, Kaartinen V, Chai Y. Alk5-mediated transforming growth factor ß signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol. 2011 May; 31(10):2079-89. PMID: 21402782; PMCID: PMC3133354.
    70. Zhuo Y, Chai YQ, Yuan R, Mao L, Yuan YL, Han J. Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker. Biosens Bioelectron. 2011 May 15; 26(9):3838-44. PMID: 21429733.
      View in: PubMed
    71. Chung IH, Han J, Iwata J, Chai Y. Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov; 48(11):645-55. PMID: 20824629; PMCID: PMC2995851.
    72. Jinno H, Morozova O, Jones KL, Biernaskie JA, Paris M, Hosokawa R, Rudnicki MA, Chai Y, Rossi F, Marra MA, Miller FD. Convergent genesis of an adult neural crest-like dermal stem cell from distinct developmental origins. Stem Cells. 2010 Nov; 28(11):2027-40. PMID: 20848654; PMCID: PMC3087810.
    73. He F, Xiong W, Wang Y, Matsui M, Yu X, Chai Y, Klingensmith J, Chen Y. Modulation of BMP signaling by Noggin is required for the maintenance of palatal epithelial integrity during palatogenesis. Dev Biol. 2010 Nov 01; 347(1):109-21. PMID: 20727875; PMCID: PMC3010875.
    74. Huang X, Xu X, Bringas P, Hung YP, Chai Y. Smad4-Shh-Nfic signaling cascade-mediated epithelial-mesenchymal interaction is crucial in regulating tooth root development. J Bone Miner Res. 2010 May; 25(5):1167-78. PMID: 19888897; PMCID: PMC3153373.
    75. Lu L, Wang J, Zhang F, Chai Y, Brand D, Wang X, Horwitz DA, Shi W, Zheng SG. Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol. 2010 Apr 15; 184(8):4295-306. PMID: 20304828; PMCID: PMC3087811.
    76. Hosokawa R, Oka K, Yamaza T, Iwata J, Urata M, Xu X, Bringas P, Nonaka K, Chai Y. TGF-beta mediated FGF10 signaling in cranial neural crest cells controls development of myogenic progenitor cells through tissue-tissue interactions during tongue morphogenesis. Dev Biol. 2010 May 01; 341(1):186-95. PMID: 20193675; PMCID: PMC3336866.
    77. Chai Y. Towards a molecular understanding of cleft palate. Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Feb 18; 42(1):9-13. PMID: 20429146.
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    78. Huang XF, Chai Y. TGF-ß signalling and tooth development. Chin J Dent Res. 2010; 13(1):7-15. PMID: 20936186.
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    79. Iwata J, Hosokawa R, Sanchez-Lara PA, Urata M, Slavkin H, Chai Y. Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells. J Biol Chem. 2010 Feb 12; 285(7):4975-82. PMID: 19959467; PMCID: PMC2836101.
    80. Han J, Mayo J, Xu X, Li J, Bringas P, Maas RL, Rubenstein JL, Chai Y. Indirect modulation of Shh signaling by Dlx5 affects the oral-nasal patterning of palate and rescues cleft palate in Msx1-null mice. Development. 2009 Dec; 136(24):4225-33. PMID: 19934017; PMCID: PMC2781056.
    81. Huang X, Bringas P, Slavkin HC, Chai Y. Fate of HERS during tooth root development. Dev Biol. 2009 Oct 01; 334(1):22-30. PMID: 19576204; PMCID: PMC2744848.
    82. Hosokawa R, Deng X, Takamori K, Xu X, Urata M, Bringas P, Chai Y. Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. J Exp Zool B Mol Dev Evol. 2009 Jun 15; 312B(4):343-50. PMID: 19235875; PMCID: PMC2896559.
    83. Noh T, Gabet Y, Cogan J, Shi Y, Tank A, Sasaki T, Criswell B, Dixon A, Lee C, Tam J, Kohler T, Segev E, Kockeritz L, Woodgett J, Müller R, Chai Y, Smith E, Bab I, Frenkel B. Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner. PLoS One. 2009; 4(5):e5438. PMID: 19412553; PMCID: PMC2673053.
    84. Chung IH, Yamaza T, Zhao H, Choung PH, Shi S, Chai Y. Stem cell property of postmigratory cranial neural crest cells and their utility in alveolar bone regeneration and tooth development. Stem Cells. 2009 Apr; 27(4):866-77. PMID: 19350689; PMCID: PMC2896558.
    85. Shi S, Chai Y, Slavkin H. Emerging opportunities for the next generation of dental implants? Dent Today. 2009 Mar; 28(3):98-9. PMID: 19323323.
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    86. Zhang Z, Lan Y, Chai Y, Jiang R. Antagonistic actions of Msx1 and Osr2 pattern mammalian teeth into a single row. Science. 2009 Feb 27; 323(5918):1232-4. PMID: 19251632; PMCID: PMC2650836.
    87. Xu X, Han J, Ito Y, Bringas P, Deng C, Chai Y. Ectodermal Smad4 and p38 MAPK are functionally redundant in mediating TGF-beta/BMP signaling during tooth and palate development. Dev Cell. 2008 Aug; 15(2):322-9. PMID: 18694570; PMCID: PMC2610417.
    88. Xu WJ, Yuan R, Chai YQ, Zhang TT, Liang WB, Wu X. Fabrication of an iodide-selective electrode based on phthalocyaninatotitanium(IV) oxide and the selective determination of iodide in actual samples. Anal Bioanal Chem. 2008 Sep; 392(1-2):297-303. PMID: 18622753.
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    89. Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J Biol Chem. 2008 Aug 22; 283(34):23139-49. PMID: 18559345.
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    90. Anthwal N, Chai Y, Tucker AS. The role of transforming growth factor-beta signalling in the patterning of the proximal processes of the murine dentary. Dev Dyn. 2008 Jun; 237(6):1604-13. PMID: 18498113.
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    91. Xing Y, Li C, Hu L, Tiozzo C, Li M, Chai Y, Bellusci S, Anderson S, Minoo P. Mechanisms of TGFbeta inhibition of LUNG endodermal morphogenesis: the role of TbetaRII, Smads, Nkx2.1 and Pten. Dev Biol. 2008 Aug 15; 320(2):340-50. PMID: 18602626; PMCID: PMC2597224.
    92. Oka K, Oka S, Hosokawa R, Bringas P, Brockhoff HC, Nonaka K, Chai Y. TGF-beta mediated Dlx5 signaling plays a crucial role in osteo-chondroprogenitor cell lineage determination during mandible development. Dev Biol. 2008 Sep 15; 321(2):303-9. PMID: 18684439; PMCID: PMC3378386.
    93. Zhao H, Oka K, Bringas P, Kaartinen V, Chai Y. TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 01; 320(1):19-29. PMID: 18572160; PMCID: PMC3629921.
    94. De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS One. 2008 Jan 30; 3(1):e1516. PMID: 18231602; PMCID: PMC2211394.
    95. Zehnaly A, Hosokawa R, Urata M, Chai Y. TGF-beta signaling and aplasia cutis congenita: proposed animal model. J Calif Dent Assoc. 2007 Dec; 35(12):865-9. PMID: 18240750.
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    96. Ko SO, Chung IH, Xu X, Oka S, Zhao H, Cho ES, Deng C, Chai Y. Smad4 is required to regulate the fate of cranial neural crest cells. Dev Biol. 2007 Dec 01; 312(1):435-47. PMID: 17964566; PMCID: PMC2704603.
    97. Hosokawa R, Urata M, Han J, Zehnaly A, Bringas P, Nonaka K, Chai Y. TGF-beta mediated Msx2 expression controls occipital somites-derived caudal region of skull development. Dev Biol. 2007 Oct 01; 310(1):140-53. PMID: 17727833; PMCID: PMC3337706.
    98. Pemberton TJ, Li FY, Oka S, Mendoza-Fandino GA, Hsu YH, Bringas P, Chai Y, Snead ML, Mehrian-Shai R, Patel PI. Identification of novel genes expressed during mouse tooth development by microarray gene expression analysis. Dev Dyn. 2007 Aug; 236(8):2245-57. PMID: 17626284; PMCID: PMC4457363.
    99. Han J, Ishii M, Bringas P, Maas RL, Maxson RE, Chai Y. Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development. Mech Dev. 2007 Sep-Oct; 124(9-10):729-45. PMID: 17693062; PMCID: PMC2220014.
    100. Oka S, Oka K, Xu X, Sasaki T, Bringas P, Chai Y. Cell autonomous requirement for TGF-beta signaling during odontoblast differentiation and dentin matrix formation. Mech Dev. 2007 Jul; 124(6):409-15. PMID: 17449229; PMCID: PMC2704601.
    101. Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Dev Biol. 2007 May 01; 305(1):90-102. PMID: 17335794; PMCID: PMC1892170.
    102. Oka K, Oka S, Sasaki T, Ito Y, Bringas P, Nonaka K, Chai Y. The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development. Dev Biol. 2007 Mar 01; 303(1):391-404. PMID: 17204263; PMCID: PMC2074881.
    103. Chai Y, Maxson RE. Recent advances in craniofacial morphogenesis. Dev Dyn. 2006 Sep; 235(9):2353-75. PMID: 16680722.
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    104. Dudas M, Kim J, Li WY, Nagy A, Larsson J, Karlsson S, Chai Y, Kaartinen V. Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusion. Dev Biol. 2006 Aug 15; 296(2):298-314. PMID: 16806156; PMCID: PMC1557652.
    105. Xu X, Han J, Ito Y, Bringas P, Urata MM, Chai Y. Cell autonomous requirement for Tgfbr2 in the disappearance of medial edge epithelium during palatal fusion. Dev Biol. 2006 Sep 01; 297(1):238-48. PMID: 16780827.
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    106. Zhao H, Bringas P, Chai Y. An in vitro model for characterizing the post-migratory cranial neural crest cells of the first branchial arch. Dev Dyn. 2006 May; 235(5):1433-40. PMID: 16245337; PMCID: PMC3337696.
    107. Sasaki T, Ito Y, Bringas P, Chou S, Urata MM, Slavkin H, Chai Y. TGFbeta-mediated FGF signaling is crucial for regulating cranial neural crest cell proliferation during frontal bone development. Development. 2006 Jan; 133(2):371-81. PMID: 16368934.
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    108. Choudhary B, Ito Y, Makita T, Sasaki T, Chai Y, Sucov HM. Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev Biol. 2006 Jan 15; 289(2):420-9. PMID: 16332365.
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    109. Hosokawa R, Urata MM, Ito Y, Bringas P, Chai Y. Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Invest Dermatol. 2005 Dec; 125(6):1302-9. PMID: 16354202.
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    110. Ishii M, Han J, Yen HY, Sucov HM, Chai Y, Maxson RE. Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest. Development. 2005 Nov; 132(22):4937-50. PMID: 16221730.
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    111. Plikus MV, Zeichner-David M, Mayer JA, Reyna J, Bringas P, Thewissen JG, Snead ML, Chai Y, Chuong CM. Morphoregulation of teeth: modulating the number, size, shape and differentiation by tuning Bmp activity. Evol Dev. 2005 Sep-Oct; 7(5):440-57. PMID: 16174037; PMCID: PMC4386657.
    112. Cui XM, Shiomi N, Chen J, Saito T, Yamamoto T, Ito Y, Bringas P, Chai Y, Shuler CF. Overexpression of Smad2 in Tgf-beta3-null mutant mice rescues cleft palate. Dev Biol. 2005 Feb 01; 278(1):193-202. PMID: 15649471.
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    113. Sasaki T, Ito Y, Xu X, Han J, Bringas P, Maeda T, Slavkin HC, Grosschedl R, Chai Y. LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol. 2005 Feb 01; 278(1):130-43. PMID: 15649466.
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    114. Xu X, Bringas P, Soriano P, Chai Y. PDGFR-alpha signaling is critical for tooth cusp and palate morphogenesis. Dev Dyn. 2005 Jan; 232(1):75-84. PMID: 15543606.
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    115. Jamora C, Lee P, Kocieniewski P, Azhar M, Hosokawa R, Chai Y, Fuchs E. A signaling pathway involving TGF-beta2 and snail in hair follicle morphogenesis. PLoS Biol. 2005 Jan; 3(1):e11. PMID: 15630473; PMCID: PMC539061.
    116. Ito Y, Yeo JY, Chytil A, Han J, Bringas P, Nakajima A, Shuler CF, Moses HL, Chai Y. Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects. Development. 2003 Nov; 130(21):5269-80. PMID: 12975342.
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    117. Han J, Ito Y, Yeo JY, Sucov HM, Maas R, Chai Y. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. Dev Biol. 2003 Sep 01; 261(1):183-96. PMID: 12941628.
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    118. Cui XM, Chai Y, Chen J, Yamamoto T, Ito Y, Bringas P, Shuler CF. TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion. Dev Dyn. 2003 Jul; 227(3):387-94. PMID: 12815624.
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    119. Zhang Y, Wang S, Song Y, Han J, Chai Y, Chen Y. Timing of odontogenic neural crest cell migration and tooth-forming capability in mice. Dev Dyn. 2003 Apr; 226(4):713-8. PMID: 12666208.
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    120. Chai Y, Slavkin HC. Prospects for tooth regeneration in the 21st century: a perspective. Microsc Res Tech. 2003 Apr 01; 60(5):469-79. PMID: 12619122.
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    121. Xu X, Jeong L, Han J, Ito Y, Bringas P, Chai Y. Developmental expression of Smad1-7 suggests critical function of TGF-beta/BMP signaling in regulating epithelial-mesenchymal interaction during tooth morphogenesis. Int J Dev Biol. 2003 Feb; 47(1):31-9. PMID: 12653249.
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    122. Chai Y, Ito Y, Han J. TGF-beta signaling and its functional significance in regulating the fate of cranial neural crest cells. Crit Rev Oral Biol Med. 2003; 14(2):78-88. PMID: 12764071.
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    123. Jitpukdeebodintra S, Chai Y, Snead ML. Developmental patterning of the circumvallate papilla. Int J Dev Biol. 2002 Aug; 46(5):755-63. PMID: 12216988.
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    124. Ito Y, Bringas P, Mogharei A, Zhao J, Deng C, Chai Y. Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development. Dev Dyn. 2002 May; 224(1):69-78. PMID: 11984875.
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    125. Jaskoll T, Zhou YM, Chai Y, Makarenkova HP, Collinson JM, West JD, Hajihosseini MK, Lee J, Melnick M. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs, BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FgfR2-IIIc(+/Delta), BMP7(-/-) and Pax6(-/-) mice. Cells Tissues Organs. 2002; 170(2-3):83-98. PMID: 11731698.
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