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Yang Chai, DMD, PhD, DDS

Title(s)Professor and Associate Dean, Research and Director, Center for Craniofacial Molecular Biology
Phone+1 323 442 3480
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    Collapse Biography 
    Collapse Awards and Honors
    NIDCR, NIH2013Chair of the Board of Scientific Counselors
    Craniofacial Biology Research Award2011IADR Distinguished Scientist Award
    Journal of Bone and Mineral Research2010  - 2014Editorial Board
    NIH2010 NIH MERIT Award
    2010American Association for the Advancement of Sciences (AAAS) Elected Fellow
    NIDCR, NIH2008  - 2012Member of the Board of Scientific Counselors
    JBMR2007  - 2014Editorial Board DEVELOPMENTAL BIOLOGY
    The Chinese Journal of Dental Research2006  - 2014Editorial Board
    2004  - 2008Regular member of SBDD study section CSR NIH
    2004Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
    2006Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration
    2002  - 2014NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK
    University of Southern California2001  - 2003Award of Excellence in Teaching
    University of Southern California1997James H. Zumberge Faculty Research and Innovation Award
    University of Southern California2007James H. Zumberge Faculty Research and Innovation Award
    University of Southern California1997Annual Excellence in Teaching Award
    1996OKU Scholarship award for outstanding academic performance
    1996Special Recognition by the Dean for outstanding service and contribution to the University of Southe
    University of Southern California, School of Dentistry1995Annual Teaching Award
    University of Southern California, (GPA 4.0)1991PHI KAPPA PHI, All-University Honor Society
    University of Southern California1990Certificate for Outstanding Academic Achievement

    Collapse Overview 
    Collapse Overview
    Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

    Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

    Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

    Collapse Research 
    Collapse Research Activities and Funding
    USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub
    NIH/NIDCR U01DE028729Aug 1, 2019 - Jul 31, 2024
    Role: Co-Principal Investigator
    Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH/NIDCR U24DE026914Mar 1, 2017 - Feb 29, 2020
    Role: Co-Principal Investigator
    Molecular and Cellular Basis of Craniosynostosis
    NIH/NIDCR R01DE026339Jul 1, 2016 - Mar 31, 2021
    Role: Co-Principal Investigator
    MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISORS
    NIH/NIDCR R01DE025221May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator
    CENTER FOR DENTAL, ORAL AND CRANIOFACIAL TISSUE ORGAN REGENERATION (C-DOCTOR)
    NIH/NIDCR R34DE025575Sep 1, 2015 - Aug 31, 2016
    Role: Principal Investigator
    INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESIS
    NIH/NIDCR U01DE024421May 12, 2014 - Apr 30, 2019
    Role: Principal Investigator
    THE MOLECULAR REGULATORY MECHANISM OF TOOTH ROOT DEVELOPMENT
    NIH/NIDCR R01DE022503Jul 19, 2012 - Apr 30, 2024
    Role: Principal Investigator
    RESEARCH ON FUNCTIONAL GENOMICS, IMAGE ANALYSIS AND RESCUE OF CLEFT PALATE
    NIH/NIDCR U01DE020065Sep 21, 2009 - Apr 30, 2014
    Role: Principal Investigator
    Interdisciplinary New Faculty Recruitment in Craniofacial Development
    NIH/NIDCR P30DE020750Sep 17, 2009 - Aug 31, 2013
    Role: Principal Investigator
    Molecular Regulatory Mechanism of Calvarial Morphogenesis
    NIH/NIDCR R01DE017007Sep 1, 2005 - Aug 31, 2012
    Role: Principal Investigator
    CRANIOFACIAL MORHOGENESIS AND TISSUE REGENERATION GORDON CONFERENCE
    NIH/NIDCR R13DE015783Jan 1, 2004 - Dec 31, 2008
    Role: Co-Principal Investigator
    MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    NIH/NIDCR R01DE014078Apr 1, 2001 - Jun 30, 2014
    Role: Principal Investigator
    TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH/NIDCR R01DE012711Jan 1, 1999 - Jul 31, 2024
    Role: Principal Investigator
    TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH/NIDCR R37DE012711Jan 1, 1999 - Jun 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Janecková E, Feng J, Li J, Rodriguez G, Chai Y. Dynamic activation of Wnt, Fgf, and Hh signaling during soft palate development. PLoS One. 2019; 14(10):e0223879. PMID: 31613912.
      View in: PubMed
    2. Shim H, Sim K, Ershad F, Yang P, Thukral A, Rao Z, Kim HJ, Liu Y, Wang X, Gu G, Gao L, Wang X, Chai Y, Yu C. Stretchable elastic synaptic transistors for neurologically integrated soft engineering systems. Sci Adv. 2019 Oct; 5(10):eaax4961. PMID: 31646177.
      View in: PubMed
    3. Jing J, Feng J, Li J, Han X, He J, Ho TV, Du J, Zhou X, Urata M, Chai Y. Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars. Elife. 2019 07 01; 8. PMID: 31259687.
      View in: PubMed
    4. Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 May 15; 28(10):1726-1737. PMID: 30689861.
      View in: PubMed
    5. Yuan Y, Chai Y. Regulatory mechanisms of jaw bone and tooth development. Curr Top Dev Biol. 2019; 133:91-118. PMID: 30902260.
      View in: PubMed
    6. Guo Y, Zhang W, Wu H, Han J, Zhang Y, Lin S, Liu C, Xu K, Qiao J, Ji W, Chen Q, Gao S, Zhang W, Zhang X, Chai Y. Discovering the forbidden Raman modes at the edges of layered materials. Sci Adv. 2018 Dec; 4(12):eaau6252. PMID: 30555917.
      View in: PubMed
    7. Guo Y, Yuan Y, Wu L, Ho TV, Jing J, Sugii H, Li J, Han X, Feng J, Guo C, Chai Y. BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair. Bone Res. 2018; 6:30. PMID: 30345151.
      View in: PubMed
    8. Zhang H, Han X, Tian Y, Li Y, Yang K, Hao H, Chai Y, Xu X. Process analysis of anaerobic fermentation of Phragmites australis straw and cow dung exposing to elevated chromium (VI) concentrations. J Environ Manage. 2018 Oct 15; 224:414-424. PMID: 30075309.
      View in: PubMed
    9. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 07 05; 23(1):147. PMID: 29979989.
      View in: PubMed
    10. Li J, Yuan Y, He J, Feng J, Han X, Jing J, Ho TV, Xu J, Chai Y. Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion. Dev Biol. 2018 09 01; 441(1):191-203. PMID: 29981310.
      View in: PubMed
    11. An Z, Akily B, Sabalic M, Zong G, Chai Y, Sharpe PT. Regulation of Mesenchymal Stem to Transit-Amplifying Cell Transition in the Continuously Growing Mouse Incisor. Cell Rep. 2018 06 05; 23(10):3102-3111. PMID: 29874594.
      View in: PubMed
    12. Xing M, Zhou Y, Dong C, Cai L, Zeng L, Shen B, Pan L, Dong C, Chai Y, Zhang J, Yin Y. Modulation of the Reduction Potential of TiO2- x by Fluorination for Efficient and Selective CH4 Generation from CO2 Photoreduction. Nano Lett. 2018 06 13; 18(6):3384-3390. PMID: 29701060.
      View in: PubMed
    13. Gou Y, Li J, Wu J, Gupta R, Cho I, Ho TV, Chai Y, Merrill A, Wang J, Xu J. Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 08; 152:13-20. PMID: 29727702.
      View in: PubMed
    14. Li SK, Liu ZT, Li JY, Chen AY, Chai YQ, Yuan R, Zhuo Y. Enzyme-free Target Recycling and Double-Output Amplification System for Electrochemiluminescent Assay of Mucin 1 with MoS2 Nanoflowers as Co-reaction Accelerator. ACS Appl Mater Interfaces. 2018 May 02; 10(17):14483-14490. PMID: 29664278.
      View in: PubMed
    15. Bobarnac Dogaru GL, Juneja SC, Shokrani A, Hui RY, Chai Y, Pepper JP. The role of Hedgehog-responsive fibroblasts in facial nerve regeneration. Exp Neurol. 2018 05; 303:72-79. PMID: 29337143.
      View in: PubMed
    16. Sugii H, Grimaldi A, Li J, Parada C, Vu-Ho T, Feng J, Jing J, Yuan Y, Guo Y, Maeda H, Chai Y. The Dlx5-FGF10 signaling cascade controls cranial neural crest and myoblast interaction during oropharyngeal patterning and development. Development. 2017 11 01; 144(21):4037-4045. PMID: 28982687.
      View in: PubMed
    17. Zeng WJ, Liao N, Lei YM, Zhao J, Chai YQ, Yuan R, Zhuo Y. Hemin as electrochemically regenerable co-reaction accelerator for construction of an ultrasensitive PTCA-based electrochemiluminescent aptasensor. Biosens Bioelectron. 2018 Feb 15; 100:490-496. PMID: 28965054.
      View in: PubMed
    18. He D, Qiao J, Zhang L, Wang J, Lan T, Qian J, Li Y, Shi Y, Chai Y, Lan W, Ono LK, Qi Y, Xu JB, Ji W, Wang X. Ultrahigh mobility and efficient charge injection in monolayer organic thin-film transistors on boron nitride. Sci Adv. 2017 09; 3(9):e1701186. PMID: 28913429.
      View in: PubMed
    19. Zhao J, Liang WB, Lei YM, Ou YX, Chai YQ, Yuan R, Zhuo Y. An efficient electrochemiluminescence amplification strategy via bis-co-reaction accelerator for sensitive detection of laminin to monitor overnutrition associated liver damage. Biosens Bioelectron. 2017 Dec 15; 98:317-324. PMID: 28697444.
      View in: PubMed
    20. Johnson MB, Pang B, Gardner DJ, Niknam-Benia S, Soundarajan V, Bramos A, Perrault DP, Banks K, Lee GK, Baker RY, Kim GH, Lee S, Chai Y, Chen M, Li W, Kwong L, Hong YK, Wong AK. Topical Fibronectin Improves Wound Healing of Irradiated Skin. Sci Rep. 2017 06 20; 7(1):3876. PMID: 28634413.
      View in: PubMed
    21. Ma S, Zeng L, Tao L, Tang CY, Yuan H, Long H, Cheng PK, Chai Y, Chen C, Fung KH, Zhang X, Lau SP, Tsang YH. Enhanced Photocatalytic Activity of WS2 Film by Laser Drilling to Produce Porous WS2/WO3 Heterostructure. Sci Rep. 2017 06 09; 7(1):3125. PMID: 28600560.
      View in: PubMed
    22. Feng J, Jing J, Li J, Zhao H, Punj V, Zhang T, Xu J, Chai Y. BMP signaling orchestrates a transcriptional network to control the fate of mesenchymal stem cells in mice. Development. 2017 07 15; 144(14):2560-2569. PMID: 28576771.
      View in: PubMed
    23. Tian H, Feng J, Li J, Ho TV, Yuan Y, Liu Y, Brindopke F, Figueiredo JC, Magee W, Sanchez-Lara PA, Chai Y. Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate. Hum Mol Genet. 2017 03 01; 26(5):860-872. PMID: 28069795.
      View in: PubMed
    24. Li J, Parada C, Chai Y. Cellular and molecular mechanisms of tooth root development. Development. 2017 02 01; 144(3):374-384. PMID: 28143844.
      View in: PubMed
    25. Long M, Zhang T, Chai Y, Ng CF, Mak TC, Xu J, Yan K. Nonstoichiometric acid-base reaction as reliable synthetic route to highly stable CH3NH3PbI3 perovskite film. Nat Commun. 2016 11 15; 7:13503. PMID: 27843140.
      View in: PubMed
    26. Park S, Zhao H, Urata M, Chai Y. Sutures Possess Strong Regenerative Capacity for Calvarial Bone Injury. Stem Cells Dev. 2016 12 01; 25(23):1801-1807. PMID: 27762665.
      View in: PubMed
    27. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 11 15; 143(22):4115-4126. PMID: 27660324.
      View in: PubMed
    28. Feng J, Jing J, Sanchez-Lara PA, Bootwalla MS, Buckley J, Wu N, Yan Y, Chai Y. Generation and characterization of tamoxifen-inducible Pax9-CreER knock-in mice using CrispR/Cas9. Genesis. 2016 09; 54(9):490-6. PMID: 27381449.
      View in: PubMed
    29. Zhao J, Lei YM, Chai YQ, Yuan R, Zhuo Y. Novel electrochemiluminescence of perylene derivative and its application to mercury ion detection based on a dual amplification strategy. Biosens Bioelectron. 2016 Dec 15; 86:720-727. PMID: 27474970.
      View in: PubMed
    30. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J, Chai Y. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 07 15; 143(14):2677-88. PMID: 27287806.
      View in: PubMed
    31. Burg ML, Chai Y, Yao CA, Magee W, Figueiredo JC. Epidemiology, Etiology, and Treatment of Isolated Cleft Palate. Front Physiol. 2016; 7:67. PMID: 26973535.
      View in: PubMed
    32. Grimaldi A, Parada C, Chai Y. A Comprehensive Study of Soft Palate Development in Mice. PLoS One. 2015; 10(12):e0145018. PMID: 26671681.
      View in: PubMed
    33. Parada C, Chai Y. Mandible and Tongue Development. Curr Top Dev Biol. 2015; 115:31-58. PMID: 26589920.
      View in: PubMed
    34. Parada C, Han D, Grimaldi A, Sarrión P, Park SS, Pelikan R, Sanchez-Lara PA, Chai Y. Disruption of the ERK/MAPK pathway in neural crest cells as a potential cause of Pierre Robin sequence. Development. 2015 Nov 01; 142(21):3734-45. PMID: 26395480.
      View in: PubMed
    35. Liu Y, Feng J, Li J, Zhao H, Ho TV, Chai Y. An Nfic-hedgehog signaling cascade regulates tooth root development. Development. 2015 Oct 01; 142(19):3374-82. PMID: 26293299.
      View in: PubMed
    36. Li J, Feng J, Liu Y, Ho TV, Grimes W, Ho HA, Park S, Wang S, Chai Y. BMP-SHH signaling network controls epithelial stem cell fate via regulation of its niche in the developing tooth. Dev Cell. 2015 Apr 20; 33(2):125-35. PMID: 25865348.
      View in: PubMed
    37. Zhao H, Feng J, Ho TV, Grimes W, Urata M, Chai Y. The suture provides a niche for mesenchymal stem cells of craniofacial bones. Nat Cell Biol. 2015 Apr; 17(4):386-96. PMID: 25799059.
      View in: PubMed
    38. Kim TH, Bae CH, Lee JY, Lee JC, Ko SO, Chai Y, Cho ES. Temporo-spatial requirement of Smad4 in dentin formation. Biochem Biophys Res Commun. 2015 Apr 17; 459(4):706-12. PMID: 25770424.
      View in: PubMed
    39. Ho TV, Iwata J, Ho HA, Grimes WC, Park S, Sanchez-Lara PA, Chai Y. Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development. Dev Biol. 2015 Apr 15; 400(2):180-90. PMID: 25722190.
      View in: PubMed
    40. Shen WJ, Zhuo Y, Chai YQ, Yang ZH, Han J, Yuan R. Enzyme-free electrochemical immunosensor based on host-guest nanonets catalyzing amplification for procalcitonin detection. ACS Appl Mater Interfaces. 2015 Feb 25; 7(7):4127-34. PMID: 25629216.
      View in: PubMed
    41. Han J, Zhuo Y, Chai YQ, Xiang Y, Yuan R. New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal Chem. 2015 Feb 03; 87(3):1669-75. PMID: 25547661.
      View in: PubMed
    42. Chai Y. Preface. Curr Top Dev Biol. 2015; 115:xix-xxi. PMID: 26589940.
      View in: PubMed
    43. Slavkin HC, Sanchez-Lara PA, Chai Y, Urata M. A model for interprofessional health care: lessons learned from craniofacial teams. J Calif Dent Assoc. 2014 Sep; 42(9):637-44. PMID: 25265730.
      View in: PubMed
    44. Han A, Zhao H, Li J, Pelikan R, Chai Y. ALK5-mediated transforming growth factor ß signaling in neural crest cells controls craniofacial muscle development via tissue-tissue interactions. Mol Cell Biol. 2014 Aug; 34(16):3120-31. PMID: 24912677.
      View in: PubMed
    45. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 06; 14(2):160-73. PMID: 24506883.
      View in: PubMed
    46. Iwata J, Suzuki A, Yokota T, Ho TV, Pelikan R, Urata M, Sanchez-Lara PA, Chai Y. TGFß regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate. Development. 2014 Feb; 141(4):909-17. PMID: 24496627.
      View in: PubMed
    47. Zhang S, Tang C, Zhao Q, Li J, Yang L, Qie L, Fan X, Li L, Zhang N, Zhao M, Liu X, Chai Y, Zhang X, Wang H, Li Y, Li W, Zhi H, Jia G, Diao X. Development of highly polymorphic simple sequence repeat markers using genome-wide microsatellite variant analysis in Foxtail millet [Setaria italica (L.) P. Beauv]. BMC Genomics. 2014 Jan 28; 15:78. PMID: 24472631.
      View in: PubMed
    48. Zhuo Y, Liao N, Chai YQ, Gui GF, Zhao M, Han J, Xiang Y, Yuan R. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal Chem. 2014 Jan 21; 86(2):1053-60. PMID: 24328308.
      View in: PubMed
    49. Jia G, Shi S, Wang C, Niu Z, Chai Y, Zhi H, Diao X. Molecular diversity and population structure of Chinese green foxtail [Setaria viridis (L.) Beauv.] revealed by microsatellite analysis. J Exp Bot. 2013 Sep; 64(12):3645-56. PMID: 23956411.
      View in: PubMed
    50. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Chai Y. Modulation of lipid metabolic defects rescues cleft palate in Tgfbr2 mutant mice. Hum Mol Genet. 2014 Jan 01; 23(1):182-93. PMID: 23975680.
      View in: PubMed
    51. Iwata J, Suzuki A, Pelikan RC, Ho TV, Chai Y. Noncanonical transforming growth factor ß (TGFß) signaling in cranial neural crest cells causes tongue muscle developmental defects. J Biol Chem. 2013 Oct 11; 288(41):29760-70. PMID: 23950180.
      View in: PubMed
    52. Xie WB, Li Z, Shi N, Guo X, Tang J, Ju W, Han J, Liu T, Bottinger EP, Chai Y, Jose PA, Chen SY. Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells. Circ Res. 2013 Sep 27; 113(8):e76-86. PMID: 23817199.
      View in: PubMed
    53. Parada C, Li J, Iwata J, Suzuki A, Chai Y. CTGF mediates Smad-dependent transforming growth factor ß signaling to regulate mesenchymal cell proliferation during palate development. Mol Cell Biol. 2013 Sep; 33(17):3482-93. PMID: 23816882.
      View in: PubMed
    54. Mima J, Koshino A, Oka K, Uchida H, Hieda Y, Nohara K, Kogo M, Chai Y, Sakai T. Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One. 2013; 8(4):e61653. PMID: 23613893.
      View in: PubMed
    55. Gui G, Zhuo Y, Chai YQ, Liao N, Zhao M, Han J, Zhu Q, Yuan R, Xiang Y. Supersandwich-type electrochemiluminescenct aptasensor based on Ru(phen)3(2+) functionalized hollow gold nanoparticles as signal-amplifying tags. Biosens Bioelectron. 2013 Sep 15; 47:524-9. PMID: 23643946.
      View in: PubMed
    56. Pelikan RC, Iwata J, Suzuki A, Chai Y, Hacia JG. Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling. J Cell Biochem. 2013 Apr; 114(4):796-807. PMID: 23060211.
      View in: PubMed
    57. Song Z, Liu C, Iwata J, Gu S, Suzuki A, Sun C, He W, Shu R, Li L, Chai Y, Chen Y. Mice with Tak1 deficiency in neural crest lineage exhibit cleft palate associated with abnormal tongue development. J Biol Chem. 2013 Apr 12; 288(15):10440-50. PMID: 23460641.
      View in: PubMed
    58. Liao N, Zhuo Y, Chai YQ, Xiang Y, Han J, Yuan R. Reagentless electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens Bioelectron. 2013 Jul 15; 45:189-94. PMID: 23500362.
      View in: PubMed
    59. Iwata J, Suzuki A, Pelikan RC, Ho TV, Sanchez-Lara PA, Urata M, Dixon MJ, Chai Y. Smad4-Irf6 genetic interaction and TGFß-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. Development. 2013 Mar; 140(6):1220-30. PMID: 23406900.
      View in: PubMed
    60. Huang XF, Chai Y. Molecular regulatory mechanism of tooth root development. Int J Oral Sci. 2012 Dec; 4(4):177-81. PMID: 23222990.
      View in: PubMed
    61. Wang C, Jia G, Zhi H, Niu Z, Chai Y, Li W, Wang Y, Li H, Lu P, Zhao B, Diao X. Genetic diversity and population structure of Chinese foxtail millet [Setaria italica (L.) Beauv.] landraces. G3 (Bethesda). 2012 Jul; 2(7):769-77. PMID: 22870400.
      View in: PubMed
    62. Parada C, Chai Y. Roles of BMP signaling pathway in lip and palate development. Front Oral Biol. 2012; 16:60-70. PMID: 22759670.
      View in: PubMed
    63. Stephens H, Jensen B, Carpiaux W, Sedghizadeh P, Chai Y. A collaborative approach to advance student research at the University of Southern California. J Calif Dent Assoc. 2012 May; 40(5):433-6, 438-9. PMID: 22685951.
      View in: PubMed
    64. Han D, Zhao H, Parada C, Hacia JG, Bringas P, Chai Y. A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development. Development. 2012 May; 139(9):1640-50. PMID: 22438570.
      View in: PubMed
    65. Iwata J, Hacia JG, Suzuki A, Sanchez-Lara PA, Urata M, Chai Y. Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice. J Clin Invest. 2012 Mar; 122(3):873-85. PMID: 22326956.
      View in: PubMed
    66. Iwata J, Tung L, Urata M, Hacia JG, Pelikan R, Suzuki A, Ramenzoni L, Chaudhry O, Parada C, Sanchez-Lara PA, Chai Y. Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis. J Biol Chem. 2012 Jan 20; 287(4):2353-63. PMID: 22123828.
      View in: PubMed
    67. Han J, Zhuo Y, Chai YQ, Yuan YL, Yuan R. Novel electrochemical catalysis as signal amplified strategy for label-free detection of neuron-specific enolase. Biosens Bioelectron. 2012 Jan 15; 31(1):399-405. PMID: 22169815.
      View in: PubMed
    68. Hung Y, Huang X, Chai Y. Molecular regulatory mechanism of root development. J Calif Dent Assoc. 2011 May; 39(5):321-4. PMID: 21721476.
      View in: PubMed
    69. Li J, Huang X, Xu X, Mayo J, Bringas P, Jiang R, Wang S, Chai Y. SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis. Development. 2011 May; 138(10):1977-89. PMID: 21490069.
      View in: PubMed
    70. Hochheiser H, Aronow BJ, Artinger K, Beaty TH, Brinkley JF, Chai Y, Clouthier D, Cunningham ML, Dixon M, Donahue LR, Fraser SE, Hallgrimsson B, Iwata J, Klein O, Marazita ML, Murray JC, Murray S, de Villena FP, Postlethwait J, Potter S, Shapiro L, Spritz R, Visel A, Weinberg SM, Trainor PA. The FaceBase Consortium: a comprehensive program to facilitate craniofacial research. Dev Biol. 2011 Jul 15; 355(2):175-82. PMID: 21458441.
      View in: PubMed
    71. Han J, Zhuo Y, Chai YQ, Mao L, Yuan YL, Yuan R. Highly conducting gold nanoparticles-graphene nanohybrid films for ultrasensitive detection of carcinoembryonic antigen. Talanta. 2011 Jul 15; 85(1):130-5. PMID: 21645681.
      View in: PubMed
    72. Zhao H, Li S, Han D, Kaartinen V, Chai Y. Alk5-mediated transforming growth factor ß signaling acts upstream of fibroblast growth factor 10 to regulate the proliferation and maintenance of dental epithelial stem cells. Mol Cell Biol. 2011 May; 31(10):2079-89. PMID: 21402782.
      View in: PubMed
    73. Zhuo Y, Chai YQ, Yuan R, Mao L, Yuan YL, Han J. Glucose oxidase and ferrocene labels immobilized at Au/TiO2 nanocomposites with high load amount and activity for sensitive immunoelectrochemical measurement of ProGRP biomarker. Biosens Bioelectron. 2011 May 15; 26(9):3838-44. PMID: 21429733.
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    74. Chung IH, Han J, Iwata J, Chai Y. Msx1 and Dlx5 function synergistically to regulate frontal bone development. Genesis. 2010 Nov; 48(11):645-55. PMID: 20824629.
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