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Berislav V Zlokovic, MD, PhD

Title(s)Chair and Professor of Physiology & Neuroscience
Phone+1 323 442 2722
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    Other Positions
    Title(s)Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research

    Title(s)Director, Zilkha Neurogenetic Institute


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    Collapse Overview
    Berislav V. Zlokovic is the director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC, and a Professor of Biological Sciences at the Dornsife College of Letters, Arts and Sciences. Zlokovic studies the role of brain microcirculation, particularly the blood-brain barrier (BBB) in health and disease in the adult brain and during brain aging. He made major contributions to our understanding of the role of BBB in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke. Using animal models and studying human brain, his laboratory has shown that dysfunction in the BBB and brain microcirculation can accumulate before neuronal loss, and is an early biomarker of human cognitive dysfunction. His group showed that disrupted cross-talk between BBB-associated pericytes and brain capillary endothelial cells, and astrocytes and pericytes, within the neurovascular unit leads to neuronal dysfunction in both sysnapses and neurons, and that targeting these BBB pathways can reverse neurodegenerative process. He has identified genes and receptors at the BBB that regulate brain levels of Alzheimer’s amyloid-beta toxin, which accumulates with aging and dementia. More recently, his team has developed new imaging techniques for studying neurovascular functions in animal models and the living human brain. These findings contributed to development of Phase 2/3 clinical trials for AD patients. He co-discovered with J.H. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C (APC) in the CNS, including the receptor requirements and downstream signaling pathways. These findings have been translated in successfully completed Phase 2 trial of 3K3A-APC, a 2nd generation cytoprotective-selective APC analog, in ischemic stroke patients, which led to a Phase 3 efficacy and safety pivotal trial of 3K3A-APC in patients with ischemic stroke.

    Current research interests
    • We study humans at genetic risk for AD, and use transgenic models, and iPSC-based human models of the BBB and brain on a chip to understand how genes that carry risk for sporadic AD (e.g., APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD disease onset and progression.
    • We are developing cell and gene therapy approaches for AD using i) iPSC-derived human pericytes that express different protective target genes, and/or ii) BBB cell-specific gene delivery to influence neuronal and synaptic functions.
    • We study APC biologics and mimetic peptides for white matter stroke, AD and ALS.
    • We work on identifying small molecules that influence genes/pathways linked to AD.
    • We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
    • Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic and human iPSC models.
    • We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human tissue studies.
    Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 17 consecutive years (2002-2019) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, Potamkin Prize from the American Academy of Neurology " in recognition of outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, Javits Award from NINDS "in recognition of distinguished record of substantial contributions in a field of neurological sciences”, and MERIT Award from NIA "in recognition of sustained contribution to aging and leadership and commitment to the field”. He is a fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. In 2017, 2018, 2019 and 2020, he was asked by the Nobel Assembly at Karolinska Institutet, The Nobel Committee to nominate candidates for the Nobel Prize in Physiology and Medicine. He is also an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders.

    Featured Publications representing interests of the Zlokovic laboratory:

    i-10 index: 243; h-index: 99; 43,599 citations (Google Scholar, Jan 2020); complete list in Google Scholar: https://goo.gl/2Npcj2
    Nation DA, Sweeney MD, Montagne A, Sagare AP, D’Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel D, Liu CY, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV (2019) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine 25, 270-276.

    Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience 22, 1089–1098.

    Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews 99, 21-78.

    Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV (2019) 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. Journal of Experimental Medicine 216(2), 279-293.

    Lyden P, Pryor KE, Coffey CS, Cudkowicz M, …Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators. (2019) Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Annals of Neurology 85(1), 125-136.

    Sweeney MD, Kisler K, Montagne A, Toga A, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience 21(10), 1318-1331

    Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV (2018) Pericyte degeneration causes white matter dysfunction in the mouse CNS. Nature Medicine 24(3), 326-337.

    Sweeney MD, Sagare AP, Zlokovic BV (2018) Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders. Nature Reviews Neurology 14(3), 133-150.

    Kisler K, Lazic D, Sweeney M, Plunkett S, Khatib ME, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV (2018) Diverse protocols for in vivo measurements of cerebrovascular hemodynamic responses and tissue oxygen levels and delivery in the mouse brain. Nature Protocols 13(6), 1377-1402.

    Sweeney MD, Zlokovic BV (2018) A lymphatic waste-disposal system implicated in Alzheimer’s disease. Nature 560 (7717) 172-174.

    Kisler K, Nelson A, Montagne A, Zlokovic BV (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer’s disease. Nature Reviews Neuroscience 18, 419-434.

    Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV (2017) Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience 20, 406-416.

    Wang Y, Zhao Z, Rege S, Griffin JH, Goldman SA, Zlokovic BV (2016) 3K3A-APC stimulates post-ischemic neuronal repair by human neural progenitor cells in mice. Nature Medicine 22 (9): 1050-1055.

    Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience 19 (6): 771-783.

    Zhao Z, Nelson A, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of blood-brain barrier. Cell 163, Nov 19;163(5):1064-78.

    Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NQ, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance. Nature Neuroscience 18, 978-987.

    Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience 18, 521-530.

    Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.

    Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated Protein C: Biased for Translation. Blood 125 (19), 2898-2907.

    Zhao Z and Zlokovic BV (2014) Blood-Brain Barrier: A Dual Life of MFSD2A? Neuron 82, 728–730.

    Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong G, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV (2014) Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proceedings of the National Academy of Sciences USA 111(11), E1035-42.

    Bell RD, Winkler E, Sagare A, Singh I, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk B, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.

    Deane R, Singh I, Sagare A, Bell R, Ross NT, Larue B, Love R, Perry S, Deane RJ, Thiyagarajan M, Zarcone T, Friedman A, Miller BL, Zlokovic BV (2012) A novel multi-modal RAGE-specific inhibitor controls amyloid-beta-mediated brain disorder in mice. Journal of Clinical Investigation 122 (4), 1377-1392.

    Winkler E, Bell R, Zlokovic BV (2011) Functions of CNS pericytes in health and disease. Nature Neuroscience 14, 1398-1405.

    Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nature Reviews Neuroscience 12, 723-738.

    Winkler EA, Bell RD, Zlokovic BV (2011) Lack of Smad and Notch Leads to a Fatal Game of Brain Pericyte Hopscotch. Developmental Cell (Cell) 20 (3), 279-281.

    Zlokovic BV, Griffin JH (2011) Activated protein C cytoprotective pathways and implications for stroke and neurological disorders. Trends in Neurosciences 34 (4), 1198-2009.

    Zlokovic BV (2010) Neurodegeneration and the neurovascular unit. Nature Medicine 16(12), 1370-71.

    Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and the neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.

    Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV (2010) Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115, 4963-4972.

    Bell RD , Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JP, Zlokovic BV (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology 11(2), 143-153.

    Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino F, Stojanovic K, Cleveland DW, Zlokovic BV (2009) Activated protein C slows ALS-like disease by transcrptionally inhibiting SOD1 in motor neurons and microglial cells. Journal of Clinical Investigation 119(11), 3437-3440.

    Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) Apolipoprotein E isoform-specific disruption of Alzheimer’s amyloid ?-peptide clearance from mouse brain. Journal of Clinical Investigation 118(12), 4002-4013.

    Zhong Z, Deane R, Zarina A, Parisi M, Shapovalov Y, 0’Banion K, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience 11(4), 420-422.

    Zlokovic BV (2008) Blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201.

    Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Pelmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine 13 (9), 1029-1031.

    Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV (2007). Serum response factor and myocardin mediate cerebral arterial hypercontractility and blood flow dysregulation in Alzheimer’s phenotype. Proceedings of the National Academy of Sciences USA 104, 823-828.

    Mosnier L, Zlokovic BV, Griffin JH (2007) The cellular protein C pathway. Blood 109(8), 161-172.

    Cheng T, Petraglia A, Li Z, Meedakshisudaram T, Wu Z, Zhong Z, Liu D, Maggirwar SB, Deane R, Fernandez J, LaRue B, Griffin J, Chopp M, Zlokovic BV (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine 12 (11), 1278-1285.

    Zlokovic BV (2006) Remodeling after stroke. Nature Medicine 12 (4) 390-391.

    Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks A, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetski R, Song H, Hofman F, Zlokovic BV (2005) Role of MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine 11(9), 959-965.

    Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer’s neurodegeneration. Trends in Neurosciences 28, 202-208.

    Deane R, Wu Z, Davis J, Yan SD, Hamm K, Sagare A, Xu F, Spijkers P, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-beta interaction mediates differential brain efflux of Abeta isoforms. Neuron 43, 33-44.

    Liu D, Cheng T, Guo H, Fernandez AJ, Griffin JH, Song X, Zlokovic BV (2004) Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine 10, (12), 1379-1383.

    Guo H, Liu D, Gelbard H, Cheng T, Fernandez JA, Insalaca R, Griffin JH, Zlokovic BV (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41, 563-572.

    Deane R, Yan SD, Kumar R, Jovanovic S, LaRue B, Welch D, Maness L, Yu J, Zhu H, Ghiso J, Frangione B, Schmidt AM, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic BV (2003) RAGE mediates amyloid-ß peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9(7), 907-913.

    Cheng T, Liu D, Fernández JA, Griffin JH, Castellino F, Rosen E, Fukudome K, Zlokovic BV (2003) Activated protein C blocks P53-mediated apoptosis in ischemic human brain endothelium and is neuroportective. Nature Medicine 9, 338-342.

    Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003) Activated protein C alters cytosolic Ca2+ flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease-activated receptor-1. Blood 101, 4797-4801.

    Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV (2001) Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis. Circulation 103, 1799-1805.

    Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer’s amyloid-ß1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106(12), 1489-1499.

    Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B (2000) Clearance of amyloid ß-peptide from brain: transport or metabolism? Nature Medicine 6, 718-719.

    Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV (1998) Human blood-brain barrier receptors for Alzheimer's amyloid-? 1-40: Asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. Journal of Clinical Investigation 102, 734-743.

    Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: Porbable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's Disease amyloid-? at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences USA 93, 4229-4236.

    Collapse Research 
    Collapse Research Activities and Funding
    Interaction of the microbiome with the blood-brain barrier
    Open Philanthropy Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    The role of PICALM mutations in Alzheimer’s disease
    Cure Alzheimer's Fund Dec 27, 2017 - Dec 28, 2019
    Role: Principal Investigator
    Vascular Contributions To Dementia and Amyloid and Tau Lesions in APOE4
    Alzheimer's Association Sep 30, 2017 - Aug 30, 2022
    Role: Principal Investigator
    Understanding the role of the perivascular space in cerebral small vessel disease
    Fondation Leducq Jan 1, 2017 - Jan 1, 2022
    Role: North American Coordinator
    The role of pericytes in white matter disease
    NIH/NINDS R01NS100459Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
    NIH/NIA P01AG052350Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Activated protein C system in stroke models
    NIH/NINDS R01NS090904Sep 30, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Caloric restriction and Alzheimers ABeta clearance pathway
    NIH/NIA R03AG046216Aug 15, 2013 - May 31, 2016
    Role: Principal Investigator
    The role of PICALM in vascular clearance of amyloid-b
    Cure Alzheimer's Fund Sep 1, 2012 - Nov 30, 2019
    Role: Principal Investigator
    The role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathology
    NIH/NIA R01AG039452Aug 1, 2011 - Nov 30, 2023
    Role: Principal Investigator
    Protein S: Neurovascular Protection in Stroke
    NIH/NHLBI R01HL081528Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH/NIA R01AG023084Dec 1, 2003 - Mar 31, 2020
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH/NIA R37AG023084Dec 1, 2003 - Jan 31, 2012
    Role: Principal Investigator
    Regulation of Brain Thrombosis in Stroke Models
    NIH/NHLBI R01HL063290Jul 15, 1999 - Jun 30, 2009
    Role: Principal Investigator
    AGING BRAIN--CEREBROVASCULAR MECHANISM &AMYLOID BETA
    NIH/NIA P01AG016223May 1, 1999 - Apr 30, 2004
    Role: Principal Investigator
    AGING AND BLOOD BRAIN BARRIER AB TRASPORT IN PRIMATES
    NIH/NIA R03AG014526Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrier
    NIH/NINDS R01NS034467Sep 1, 1995 - Mar 31, 2019
    Role: Principal Investigator
    Alzheimer's Abeta, apolipoproteins and blood-brain barrier
    NIH/NINDS R37NS034467Sep 1, 1995 - Mar 31, 2014
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH/NEI R01EY009399Aug 1, 1993 - Jul 31, 1996
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH/NEI R55EY009399Sep 30, 1992 - Jul 31, 1993
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020 03; 16(3):137-153. PMID: 32094487.
      View in: PubMed
    2. Montagne A, Nation DA, Zlokovic BV. APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 Mar; 51(3):699-700. PMID: 32070225.
      View in: PubMed
    3. Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020; 14:27. PMID: 32116568.
      View in: PubMed
    4. Lazic D, Tesic V, Jovanovic M, Brkic M, Milanovic D, Zlokovic BV, Kanazir S, Perovic M. Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease. Neurobiol Dis. 2020 Jan 10; 136:104745. PMID: 31931140.
      View in: PubMed
    5. Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 Dec; 15(12):1568-1575. PMID: 31862169.
      View in: PubMed
    6. Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-a in APOE4 carriers. Neurobiol Aging. 2020 Feb; 86:112-122. PMID: 31870643.
      View in: PubMed
    7. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22; 1747493019871915. PMID: 31543058.
      View in: PubMed
    8. Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 Oct 03; 25(4):486-500.e9. PMID: 31523028.
      View in: PubMed
    9. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. PMID: 31310593.
      View in: PubMed
    10. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 Jul; 15(7):961-984. PMID: 31327392.
      View in: PubMed
    11. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. PMID: 31235908.
      View in: PubMed
    12. Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ. Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis. Am J Physiol Heart Circ Physiol. 2019 Aug 01; 317(2):H255-H263. PMID: 31125259.
      View in: PubMed
    13. Jovic M, Loncarevic-Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, Kanazir S. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS One. 2019; 14(5):e0216726. PMID: 31095617.
      View in: PubMed
    14. Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2019 04 09; 27(2):549-560.e6. PMID: 30970257.
      View in: PubMed
    15. Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76. PMID: 30661727.
      View in: PubMed
    16. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. PMID: 30647119.
      View in: PubMed
    17. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. PMID: 30643288.
      View in: PubMed
    18. Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136. PMID: 30450637.
      View in: PubMed
    19. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. PMID: 30642436.
      View in: PubMed
    20. Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 01 01; 99(1):21-78. PMID: 30280653.
      View in: PubMed
    21. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-ß42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018 10 19; 13(1):57. PMID: 30340601.
      View in: PubMed
    22. Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018 10; 21(10):1318-1331. PMID: 30250261.
      View in: PubMed
    23. Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM. Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res. 2018 09 01; 114(11):1462-1473. PMID: 29726891.
      View in: PubMed
    24. Sweeney MD, Zlokovic BV. A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature. 2018 08; 560(7717):172-174. PMID: 30076374.
      View in: PubMed
    25. Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C, protease activated receptor 1, and neuroprotection. Blood. 2018 07 12; 132(2):159-169. PMID: 29866816.
      View in: PubMed
    26. Netto JP, Iliff J, Stanimirovic D, Krohn KA, Hamilton B, Varallyay C, Gahramanov S, Daldrup-Link H, d'Esterre C, Zlokovic B, Sair H, Lee Y, Taheri S, Jain R, Panigrahy A, Reich DS, Drewes LR, Castillo M, Neuwelt EA. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. Neurosurgery. 2018 06 01; 82(6):770-780. PMID: 28973554.
      View in: PubMed
    27. Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadži S, Zlokovic BV. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nat Protoc. 2018 06; 13(6):1377-1402. PMID: 29844521.
      View in: PubMed
    28. Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. PMID: 29611451.
      View in: PubMed
    29. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. PMID: 29400714.
      View in: PubMed
    30. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. PMID: 29400711.
      View in: PubMed
    31. Sweeney MD, Sagare AP, Zlokovic BV. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 03; 14(3):133-150. PMID: 29377008.
      View in: PubMed
    32. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. PMID: 29343482.
      View in: PubMed
    33. Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. PMID: 29192539.
      View in: PubMed
    34. Montagne A, Zhao Z, Zlokovic BV. Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169. PMID: 29061693.
      View in: PubMed
    35. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. PMID: 28923278.
      View in: PubMed
    36. Nelson AR, Sagare AP, Zlokovic BV. Role of clusterin in the brain vascular clearance of amyloid-ß. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. PMID: 28765369.
      View in: PubMed
    37. Zhao Z, Zlokovic BV. Remote control of BBB: A tale of exosomes and microRNA. Cell Res. 2017 07; 27(7):849-850. PMID: 28674430.
      View in: PubMed
    38. Kisler K, Nelson AR, Montagne A, Zlokovic BV. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434. PMID: 28515434.
      View in: PubMed
    39. Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017 May 01; 14(1):12. PMID: 28457227.
      View in: PubMed
    40. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-ß signaling. PLoS One. 2017; 12(4):e0176225. PMID: 28441414.
      View in: PubMed
    41. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. PMID: 28135240.
      View in: PubMed
    42. Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. PMID: 27758767.
      View in: PubMed
    43. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. PMID: 27548576.
      View in: PubMed
    44. Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 2016 11 03; 19(5):663-671. PMID: 27524440.
      View in: PubMed
    45. Sweeney MD, Ayyadurai S, Zlokovic BV. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci. 2016 05 26; 19(6):771-83. PMID: 27227366.
      View in: PubMed
    46. Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4. PMID: 27207428.
      View in: PubMed
    47. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707. PMID: 27038189.
      View in: PubMed
    48. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. Clearance systems in the brain--implications for Alzheimer diseaser. Nat Rev Neurol. 2016 Apr; 12(4):248. PMID: 27020556.
      View in: PubMed
    49. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. PMID: 26941593.
      View in: PubMed
    50. Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. PMID: 26198175.
      View in: PubMed
    51. Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. PMID: 25757756.
      View in: PubMed
    52. Montagne A, Toga AW, Zlokovic BV. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4. PMID: 26524294.
      View in: PubMed
    53. Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900. PMID: 26705676.
      View in: PubMed
    54. Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 2015 Nov 19; 163(5):1064-1078. PMID: 26590417.
      View in: PubMed
    55. Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. Shedding of soluble platelet-derived growth factor receptor-ß from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101. PMID: 26407747.
      View in: PubMed
    56. Amar AP, Griffin JH, Zlokovic BV. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. PMID: 26388732.
      View in: PubMed
    57. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015 Aug; 11(8):457-70. PMID: 26195256.
      View in: PubMed
    58. Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. PMID: 26236233.
      View in: PubMed
    59. Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. PMID: 26076957.
      View in: PubMed
    60. Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77. PMID: 26077645.
      View in: PubMed
    61. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. PMID: 26005850.
      View in: PubMed
    62. Montagne A, Pa J, Zlokovic BV. Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol. 2015 May; 72(5):495-6. PMID: 25751405.
      View in: PubMed
    63. Sweeney MD, Sagare AP, Zlokovic BV. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. PMID: 25899298.
      View in: PubMed
    64. Griffin JH, Zlokovic BV, Mosnier LO. Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907. PMID: 25824691.
      View in: PubMed
    65. Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. PMID: 25859293.
      View in: PubMed
    66. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530. PMID: 25730668.
      View in: PubMed
    67. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. PMID: 25611508.
      View in: PubMed
    68. Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 2015 Jun; 11(6):710-7. PMID: 25510382.
      View in: PubMed
    69. Mosnier LO, Zlokovic BV, Griffin JH. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92. PMID: 25230930.
      View in: PubMed
    70. Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. Negative regulation of NF-?B activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014 Sep 05; 5:4820. PMID: 25190485.
      View in: PubMed
    71. Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, Sieber BA, Silverberg NB, Sutherland M, Torborg CL, Waddy SP, Zlokovic BV, Corriveau RA. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 2014 Aug 26; 83(9):851-60. PMID: 25080517.
      View in: PubMed
    72. Winkler EA, Sagare AP, Zlokovic BV. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86. PMID: 24946075.
      View in: PubMed
    73. Zhao Z, Zlokovic BV. Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30. PMID: 24853933.
      View in: PubMed
    74. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. PMID: 24591593.
      View in: PubMed
    75. Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. J Thromb Haemost. 2013 Nov; 11(11):2059-62. PMID: 24034518.
      View in: PubMed
    76. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. PMID: 24159062.
      View in: PubMed
    77. Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200. PMID: 24030206.
      View in: PubMed
    78. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-ß and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66. PMID: 23580652.
      View in: PubMed
    79. Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90. PMID: 23554499.
      View in: PubMed
    80. Zlokovic BV. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol. 2013 Apr; 70(4):440-4. PMID: 23400708.
      View in: PubMed
    81. Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. PMID: 23541526.
      View in: PubMed
    82. Zlokovic BV. A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4. PMID: 23441580.
      View in: PubMed
    83. Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104. PMID: 23438513.
      View in: PubMed
    84. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013; 4:2932. PMID: 24336108.
      View in: PubMed
    85. Sagare AP, Bell RD, Zlokovic BV. Neurovascular defects and faulty amyloid-ß vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. PMID: 22751174.
      View in: PubMed
    86. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85. PMID: 24372304.
      View in: PubMed
    87. Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol. 2013 May; 23(3):303-10. PMID: 23126372.
      View in: PubMed
    88. Sagare AP, Bell RD, Zlokovic BV. Neurovascular dysfunction and faulty amyloid ß-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). PMID: 23028132.
      View in: PubMed
    89. Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol. 2013 Jan; 125(1):111-20. PMID: 22941226.
      View in: PubMed
    90. Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aß clearance in a mouse model of ß-amyloidosis. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. PMID: 22927427.
      View in: PubMed
    91. Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. PMID: 22850407.
      View in: PubMed
    92. Sagare AP, Deane R, Zlokovic BV. Low-density lipoprotein receptor-related protein 1: a physiological Aß homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 2012 Oct; 136(1):94-105. PMID: 22820095.
      View in: PubMed
    93. Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9. PMID: 22811462.
      View in: PubMed
    94. Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G. Hypertension induces brain ß-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension. 2012 Jul; 60(1):188-97. PMID: 22615109.
      View in: PubMed
    95. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 16; 485(7399):512-6. PMID: 22622580.
      View in: PubMed
    96. Griffin JH, Zlokovic BV, Mosnier LO. Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45. PMID: 22477541.
      View in: PubMed
    97. Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. A multimodal RAGE-specific inhibitor reduces amyloid ß-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92. PMID: 22406537.
      View in: PubMed
    98. Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. PMID: 22632606.
      View in: PubMed
    99. Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. PMID: 22048062.
      View in: PubMed
    100. Winkler EA, Bell RD, Zlokovic BV. Central nervous system pericytes in health and disease. Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. PMID: 22030551.
      View in: PubMed
    101. Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-ß levels. J Neurosci Res. 2011 Jul; 89(7):967-8. PMID: 21544850.
      View in: PubMed
    102. Zhong Z, Winkler EA, Zlokovic BV. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. PMID: 21413850.
      View in: PubMed
    103. Winkler EA, Bell RD, Zlokovic BV. Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell. 2011 Mar 15; 20(3):279-80. PMID: 21397835.
      View in: PubMed
    104. Zlokovic BV, Griffin JH. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209. PMID: 21353711.
      View in: PubMed
    105. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. PMID: 21291561.
      View in: PubMed
    106. Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-ß is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis. 2011; 24(1):25-34. PMID: 21157031.
      View in: PubMed
    107. Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. Methamphetamine causes sustained depression in cerebral blood flow. Brain Res. 2011 Feb 10; 1373:91-100. PMID: 21156163.
      View in: PubMed
    108. Zlokovic BV. Neurodegeneration and the neurovascular unit. Nat Med. 2010 Dec; 16(12):1370-1. PMID: 21135839.
      View in: PubMed
    109. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. PMID: 21084607.
      View in: PubMed
    110. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27. PMID: 21040844.
      View in: PubMed
    111. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid ß-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89. PMID: 20854368.
      View in: PubMed
    112. Vates GE, Takano T, Zlokovic B, Nedergaard M. Pericyte constriction after stroke: the jury is still out. Nat Med. 2010 Sep; 16(9):959; author reply 960. PMID: 20823870.
      View in: PubMed
    113. Winkler EA, Bell RD, Zlokovic BV. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener. 2010 Aug 25; 5:32. PMID: 20738866.
      View in: PubMed
    114. Walker CT, Marky AH, Petraglia AL, Ali T, Chow N, Zlokovic BV. Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Res. 2010 Aug 06; 1347:125-31. PMID: 20513369.
      View in: PubMed
    115. Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72. PMID: 20348395.
      View in: PubMed
    116. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. PMID: 20043896.
      View in: PubMed
    117. Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. PMID: 20023547.
      View in: PubMed
    118. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. PMID: 19841542.
      View in: PubMed
    119. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. PMID: 19815836.
      View in: PubMed
    120. Bell RD, Zlokovic BV. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009 Jul; 118(1):103-13. PMID: 19319544.
      View in: PubMed
    121. Deane R, Bell RD, Sagare A, Zlokovic BV. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. PMID: 19275634.
      View in: PubMed
    122. Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30. PMID: 19302148.
      View in: PubMed
    123. Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24. PMID: 19166505.
      View in: PubMed
    124. Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53. PMID: 19098903.
      View in: PubMed
    125. Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009 May; 40(5):1864-9. PMID: 19057019.
      View in: PubMed
    126. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. PMID: 19036971.
      View in: PubMed
    127. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. PMID: 19033669.
      View in: PubMed
    128. Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. PMID: 18841163.
      View in: PubMed
    129. Zlokovic BV. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):409-14. PMID: 18625452.
      View in: PubMed
    130. Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. PMID: 18451334.
      View in: PubMed
    131. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. PMID: 18344992.
      View in: PubMed
    132. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24; 57(2):178-201. PMID: 18215617.
      View in: PubMed
    133. Deane R, Sagare A, Zlokovic BV. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5. PMID: 18673201.
      View in: PubMed
    134. Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71. PMID: 17971789.
      View in: PubMed
    135. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. PMID: 17694066.
      View in: PubMed
    136. Deane R, Zlokovic BV. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):191-7. PMID: 17430246.
      View in: PubMed
    137. Thiyagarajan M, Cheng T, Zlokovic BV. Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7. PMID: 17272817.
      View in: PubMed
    138. Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:40-50. PMID: 17413008.
      View in: PubMed
    139. Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. PMID: 17215356.
      View in: PubMed
    140. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. PMID: 17110453.
      View in: PubMed
    141. Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. PMID: 17077814.
      View in: PubMed
    142. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. PMID: 17072311.
      View in: PubMed
    143. Zlokovic BV. Remodeling after stroke. Nat Med. 2006 Apr; 12(4):390-1. PMID: 16598283.
      View in: PubMed
    144. Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. PMID: 16464623.
      View in: PubMed
    145. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. PMID: 16354907.
      View in: PubMed
    146. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. PMID: 16239972.
      View in: PubMed
    147. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. PMID: 16130108.
      View in: PubMed
    148. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. PMID: 16116430.
      View in: PubMed
    149. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr; 28(4):202-8. PMID: 15808355.
      View in: PubMed
    150. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. PMID: 15743889.
      View in: PubMed
    151. Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathol. 2005 Jan; 15(1):78-83. PMID: 15779240.
      View in: PubMed
    152. Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83. PMID: 15516929.
      View in: PubMed
    153. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. PMID: 15325132.
      View in: PubMed
    154. Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. PMID: 15459432.
      View in: PubMed
    155. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. PMID: 15294142.
      View in: PubMed
    156. Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16. PMID: 15183014.
      View in: PubMed
    157. Zlokovic BV. Clearing amyloid through the blood-brain barrier. J Neurochem. 2004 May; 89(4):807-11. PMID: 15140180.
      View in: PubMed
    158. Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. PMID: 15118526.
      View in: PubMed
    159. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 07; 279(19):20296-306. PMID: 14985348.
      View in: PubMed
    160. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. PMID: 14980205.
      View in: PubMed
    161. Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004 Feb; 88(4):813-20. PMID: 14756801.
      View in: PubMed
    162. Wu Z, Hofman FM, Zlokovic BV. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. PMID: 14583404.
      View in: PubMed
    163. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. PMID: 12808450.
      View in: PubMed
    164. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. PMID: 12737945.
      View in: PubMed
    165. Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. PMID: 12665496.
      View in: PubMed
    166. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. PMID: 12586611.
      View in: PubMed
    167. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. PMID: 12563316.
      View in: PubMed
    168. Amar AP, Zlokovic BV, Apuzzo ML. Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. PMID: 12535371.
      View in: PubMed
    169. Zlokovic BV. Current treatments and therapeutic targets in Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7. PMID: 12453670.
      View in: PubMed
    170. Zlokovic BV. Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1553-9. PMID: 12453672.
      View in: PubMed
    171. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. PMID: 12176746.
      View in: PubMed
    172. Griffin JH, Zlokovic B, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. PMID: 12124682.
      View in: PubMed
    173. Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun; 38(6):303-13. PMID: 12529925.
      View in: PubMed
    174. Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target. 2002 Jun; 10(4):359-68. PMID: 12164385.
      View in: PubMed
    175. Grammas P, Yamada M, Zlokovic B. The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2002 Jun; 4(3):217-23. PMID: 12226540.
      View in: PubMed
    176. Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun; 23(3):405-12. PMID: 11959403.
      View in: PubMed
    177. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73. PMID: 11311331.
      View in: PubMed
    178. Zlokovic BV, Cox C. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2001 May; 48(5):1196-7. PMID: 11334298.
      View in: PubMed
    179. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. PMID: 11282913.
      View in: PubMed
    180. MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001 Jan; 48(1):151-7. PMID: 11152340.
      View in: PubMed
    181. Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81. PMID: 11078691.
      View in: PubMed
    182. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec; 106(12):1489-99. PMID: 11120756.
      View in: PubMed
    183. Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech. 2000 Aug 15; 50(4):305-15. PMID: 10936885.
      View in: PubMed
    184. Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. PMID: 10899440.
      View in: PubMed
    185. Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9. PMID: 10888892.
      View in: PubMed
    186. Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 01; 348 Pt 2:359-65. PMID: 10816430.
      View in: PubMed
    187. Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. PMID: 10894183.
      View in: PubMed
    188. Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000 Apr; 141(4):1434-41. PMID: 10746647.
      View in: PubMed
    189. Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999 Dec 01; 344 Pt 2:375-83. PMID: 10567218.
      View in: PubMed
    190. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. PMID: 10559029.
      View in: PubMed
    191. Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. PMID: 10515502.
      View in: PubMed
    192. Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett. 1999 Sep 10; 272(2):127-30. PMID: 10507558.
      View in: PubMed
    193. Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res. 1999 Sep; 16(9):1360-5. PMID: 10496650.
      View in: PubMed
    194. Kannan R, Mackic JB, Zlokovic BV. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea. 1999 May; 18(3):321-7. PMID: 10336036.
      View in: PubMed
    195. Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol. 1999 May; 157(1):194-201. PMID: 10222122.
      View in: PubMed
    196. Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec 01; 92(5):213-9. PMID: 9851812.
      View in: PubMed
    197. MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. PMID: 9848858.
      View in: PubMed
    198. Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery. 1998 Oct; 43(4):909-13. PMID: 9766319.
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    199. Zlokovic BV, Apuzzo ML. Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998 Oct; 43(4):877-8. PMID: 9766315.
      View in: PubMed
    200. Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug 15; 91(4):191-7. PMID: 9736422.
      View in: PubMed
    201. Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. PMID: 9710442.
      View in: PubMed
    202. LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther. 1998 May 01; 9(7):989-95. PMID: 9607410.
      View in: PubMed
    203. Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan; 70(1):210-5. PMID: 9422364.
      View in: PubMed
    204. Lavine SD, Hofman FM, Zlokovic BV. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. PMID: 9428305.
      View in: PubMed
    205. Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. J Neurosurg. 1997 Nov; 87(5):731-7. PMID: 9347982.
      View in: PubMed
    206. Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. PMID: 9409303.
      View in: PubMed
    207. Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem. 1997 Nov; 69(5):1995-2004. PMID: 9349544.
      View in: PubMed
    208. Zlokovic BV. Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 1997 Jun 15; 2(6):e5. PMID: 15099052.
      View in: PubMed
    209. Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. PMID: 9227280.
      View in: PubMed
    210. Zlokovic BV, Apuzzo ML. Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. PMID: 9092853.
      View in: PubMed
    211. Zlokovic BV, Apuzzo ML. Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. PMID: 9092854.
      View in: PubMed
    212. Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs. Curr Eye Res. 1997 Apr; 16(4):365-71. PMID: 9134326.
      View in: PubMed
    213. Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. PMID: 9040492.
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    214. Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharm Res. 1997 Jan; 14(1):80-5. PMID: 9034225.
      View in: PubMed
    215. Zlokovic B. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiol Dis. 1997; 4(1):23-6. PMID: 9258908.
      View in: PubMed
    216. Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. PMID: 8843923.
      View in: PubMed
    217. Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. PMID: 8633046.
      View in: PubMed
    218. Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. PMID: 8621654.
      View in: PubMed
    219. Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke. 1996 Apr; 27(4):712-9. PMID: 8614937.
      View in: PubMed
    220. Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. PMID: 8710175.
      View in: PubMed
    221. Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5. PMID: 8932451.
      View in: PubMed
    222. Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. Cellular uptake and transport of methylprednisolone at the blood-brain barrier. Neurosurgery. 1996 Feb; 38(2):348-54. PMID: 8869063.
      View in: PubMed
    223. Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. PMID: 8674510.
      View in: PubMed
    224. Zlokovic BV. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci. 1996; 59(18):1483-97. PMID: 8890929.
      View in: PubMed
    225. Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 1995 Nov; 37(5):955-61. PMID: 8559345.
      View in: PubMed
    226. Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. PMID: 7591644.
      View in: PubMed
    227. Zlokovic BV. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res. 1995 Oct; 12(10):1395-406. PMID: 8584471.
      View in: PubMed
    228. Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. PMID: 7635653.
      View in: PubMed
    229. Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. PMID: 8642902.
      View in: PubMed
    230. Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic LM. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism. Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. PMID: 7549442.
      View in: PubMed
    231. Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. PMID: 7802679.
      View in: PubMed
    232. Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. PMID: 7859824.
      View in: PubMed
    233. Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. PMID: 8198602.
      View in: PubMed
    234. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. PMID: 8147886.
      View in: PubMed
    235. Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. PMID: 8125742.
      View in: PubMed
    236. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. PMID: 8280117.
      View in: PubMed
    237. Zlokovic BV. The blood-brain barrier in vitro: recent progress. Neurochem Int. 1993 Dec; 23(6):523. PMID: 8281120.
      View in: PubMed
    238. Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25. PMID: 8385133.
      View in: PubMed
    239. Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. PMID: 8384107.
      View in: PubMed
    240. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. PMID: 8384106.
      View in: PubMed
    241. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. PMID: 8392783.
      View in: PubMed
    242. Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Exp Eye Res. 1993 Jan; 56(1):45-50. PMID: 8432334.
      View in: PubMed
    243. Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. Differential brain penetration of cerebroprotective drugs. Adv Exp Med Biol. 1993; 331:117-20. PMID: 8333325.
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    244. Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. Blood-brain transport of vasopressin. Adv Exp Med Biol. 1993; 331:143-7. PMID: 8333329.
      View in: PubMed
    245. Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res. 1992 Sep 11; 590(1-2):213-8. PMID: 1422832.
      View in: PubMed
    246. Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Exp Eye Res. 1992 Mar; 54(3):471-7. PMID: 1381681.
      View in: PubMed
    247. Zlokovic BV, McComb JG, Perlmutter L, Weiss MH, Davson H. Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse. NIDA Res Monogr. 1992; 120:26-42. PMID: 1501689.
      View in: PubMed
    248. Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 1991 Nov-Dec; 32(6):783-90. PMID: 1743149.
      View in: PubMed
    249. Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. PMID: 1902062.
      View in: PubMed
    250. Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. PMID: 1899978.
      View in: PubMed
    251. Rosic M, Collis CS, Anjelkovic IZ, Segal MB, Djuric D, Zlokovic BV. The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta. Agents Actions Suppl. 1991; 33:283-7. PMID: 1647128.
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    252. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, Greenwood J. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem. 1990 Oct; 55(4):1222-30. PMID: 2398356.
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    253. Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. PMID: 2364078.
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    254. Segal MB, Preston JE, Collis CS, Zlokovic BV. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. PMID: 2186633.
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    255. Segal MB, Preston JE, Zlokovic B. Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep. Endocrinol Exp. 1990 Mar; 24(1-2):29-36. PMID: 2361466.
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    256. Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990 Mar; 107(3):263-70. PMID: 1689666.
      View in: PubMed
    257. Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG. Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers. Endocrinol Exp. 1990 Mar; 24(1-2):9-17. PMID: 2193795.
      View in: PubMed
    258. Kozlowski GP, Nilaver G, Zlokovic BV. Immunoneurology: a serum protein afferent limb to the CNS. Adv Exp Med Biol. 1990; 274:345-70. PMID: 2239432.
      View in: PubMed
    259. Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. J Neurol Sci. 1989 Dec; 94(1-3):41-50. PMID: 2515257.
      View in: PubMed
    260. Zlokovic BV, Mackic JB, Djuricic B, Davson H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem. 1989 Nov; 53(5):1333-40. PMID: 2795003.
      View in: PubMed
    261. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. PMID: 2548879.
      View in: PubMed
    262. Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H. Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis. 1989 Mar; 4(1):33-40. PMID: 2495422.
      View in: PubMed
    263. Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989 Mar-Apr; 10(2):249-54. PMID: 2547200.
      View in: PubMed
    264. Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metab Brain Dis. 1989 Mar; 4(1):9-15. PMID: 2495423.
      View in: PubMed
    265. Preston JE, Segal MB, Walley GJ, Zlokovic BV. Neutral amino acid uptake by the isolated perfused sheep choroid plexus. J Physiol. 1989 Jan; 408:31-43. PMID: 2506339.
      View in: PubMed
    266. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem. 1988 Jul; 51(1):252-7. PMID: 3132534.
      View in: PubMed
    267. Zlokovic BV, Segal MB, Davson H, Jankov RM. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1988 May-Jun; 9(3):533-8. PMID: 3420012.
      View in: PubMed
    268. Zlokovic BV, Andjelkovic IZ. Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. PMID: 2460051.
      View in: PubMed
    269. Zlokovic BV, Segal MB, Davson H, Mitrovic DM. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept. 1988 Jan; 20(1):33-44. PMID: 3127863.
      View in: PubMed
    270. Zlokovic BV, Davson H, Preston JE, Segal MB. The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Exp Neurol. 1987 Nov; 98(2):436-52. PMID: 2444450.
      View in: PubMed
    271. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem. 1987 Jul; 49(1):310-5. PMID: 3585338.
      View in: PubMed
    272. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J Neurochem. 1986 May; 46(5):1444-51. PMID: 3083044.
      View in: PubMed
    273. Zlokovic BV, Segal MB, Begley DJ, Davson H, Rakic L. Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 1985 Dec 09; 358(1-2):191-9. PMID: 3935272.
      View in: PubMed
    274. Mann GE, Zlokovic BV, Yudilevich DL. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. PMID: 4041458.
      View in: PubMed
    275. Zlokovic BV, Begley DJ, Chain-Eliash DG. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985 Jun 10; 336(1):125-32. PMID: 3891014.
      View in: PubMed
    276. Zlokovic BV, Begley DJ, Chain DG. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res. 1983 Jul 18; 271(1):65-71. PMID: 6883121.
      View in: PubMed
    277. Andjelkovic I, Zlokovic B. Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol. 1982 Jul; 76(3):483-9. PMID: 6179557.
      View in: PubMed
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