Berislav V Zlokovic, MD, PhD

Title(s)Chair and University Professor of Physiology & Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 101 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2722
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    Other Positions
    Title(s)Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research

    Title(s)Director, Zilkha Neurogenetic Institute


    Collapse Overview 
    Collapse Overview
    Berislav Zlokovic, MD, PhD is the University Professor, Mary Hayley and Selim K. Zilkha Chair in Alzheimer’s Disease Research, director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC. Zlokovic studies the role of brain microcirculation, particularly the blood-brain barrier (BBB) in health and disease in the adult and aging brain. He made major contributions to our understanding of the role of BBB in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke. Using animal models and studying human brain, his laboratory has shown that dysfunction in the BBB and brain microcirculation can accumulate before neuronal loss and is an early biomarker of human cognitive dysfunction. His group showed that disrupted cross-talk between BBB-associated pericytes and brain capillary endothelial cells within the neurovascular unit leads to neuronal dysfunction in both synapses and neurons. He showed that targeting the BBB cellular and molecular pathways by gene and cell therapy approaches, small molecules and/or biologics can slow down, arrest and/or prevent development of neurodegenerative changes. He has identified genes and receptors at the BBB that regulate brain levels of Alzheimer’s amyloid-beta toxin, which accumulates with aging and in AD. His team has developed new imaging techniques for studying BBB function in animal models and the living human brain. His findings contributed to development of Phase 2/3 clinical trials for AD. He co-discovered with J.H. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C (APC) in the CNS, including the receptor requirements and downstream signaling pathways. These findings have been translated in successfully completed Ph 1 and Ph 2 trial of 3K3A-APC, a 2nd generation cell-signaling APC analog, in ischemic stroke patients, which led to a Ph 3 efficacy pivotal trial of 3K3A-APC in patients with ischemic stroke.

    Current research interests:
    • We study humans at genetic risk for AD, use transgenic models, and iPSC-based human models of the BBB to understand how genes that carry risk for sporadic AD (APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD onset and progression.
    • We are developing gene and cell therapy approaches for AD using i) BBB cell-specific gene delivery; and ii) iPSC-derived human pericytes to influence and protect neuronal and synaptic functions.
    • We study APC biologics and mimetic peptides in the white matter stroke, AD and ALS.
    • We work on identifying small molecules that influence genes/pathways linked to AD.
    • We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
    • We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human brain tissue.
    • Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic models of AD.

    Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 21 consecutive years (2002-2022) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received the MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, the Potamkin Prize from the American Academy of Neurology in recognition of “outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, the Javits Award from the NINDS in recognition of “distinguished record of substantial contributions in a field of neurological sciences”, the MERIT Award from the NIA in recognition of “sustained contribution to aging and leadership and commitment to the field”, and the USC Associates Award for Creativity in Research and Scholarship “the highest honor the university faculty bestows on its members for distinguished intellectual achievements”. He is the University Professor “awarded very selectively by the President based on multi-disciplinary interests and significant accomplishments in several disciplines”. He is fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. He was appointed nominator for the Nobel Prize in Physiology and Medicine for 5 consecutive years (2017-2022). He is an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders.
    Collapse In The News

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    Collapse Research Activities and Funding
    PICALM: Role in the pathogenesis and treatment of Alzheimer vascular blood-brain barrier clearance dysfunction, neuronal dysfunction, and amyloid-beta, tau and neurodegenerative disorders
    NIH RF1AG076921Aug 15, 2022 - Jul 31, 2025
    Role: Principal Investigator
    Understanding Why the Major Susceptibility Gene for Alzheimer's Disease, APOE4, Affects Women More Than Men
    Krueger Settlement Jan 1, 2022 - Dec 31, 2026
    Role: Principal Investigator
    Cellular and Molecular studies of APOE regulation of Blood-Brain Barrier, Synaptic and Neuronal Functions and Protection Strategies in Mouse Models with and without Alzheimer's Pathology
    Cure Alzheimer's Fund 014795-00001Jan 1, 2022 - Jun 30, 2024
    Role: Principal Investigator
    Alzheimer Disease Research Center
    NIH P30AG066530Sep 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injury
    NIH R01NS117827Jul 15, 2020 - Apr 30, 2025
    Role: Principal Investigator
    BBB Permeability Imaging in CADASIL
    NIH R01NS114382Feb 1, 2020 - Jan 31, 2025
    Role: Co-Investigator
    Molecular Signatures of APOE-mediated Blood-Brain Barrier Dysfunction Causing Neuronal and Synaptic Dysfunction
    Cure Alzheimer's Fund 012032-00001Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
    Interaction of the microbiome with the blood brain barrier
    Good Ventures Foundation 010337-00001Oct 8, 2018 - Oct 31, 2025
    Role: Principal Investigator
    Urban Air Pollution and Alzheimer's Disease: Risk, Heterogeneity, and Mechanisms
    NIH P01AG055367Jul 1, 2018 - Jun 30, 2023
    Role: Co-Investigator
    Vascular Contributions To Dementia and Amyloid and Tau Lesions in APOE4
    Alzheimer's Association 008369-00001Jun 1, 2017 - Jun 30, 2025
    Role: Principal Investigator
    Description: To investigate preclinical changes in cerebrospinal fluid and imaging biomarkers of vascular/Blood-brain barrier injury in cognitively normal APOE4 carriers relative to non-carriers.
    Understanding the role of the perivascular space in cerebral small vessel disease
    Fondation Leducq 007851-00001Jan 1, 2017 - Dec 31, 2023
    Role: North American Coordinator
    Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
    NIH P01AG052350-06Sep 30, 2016 - Mar 31, 2027
    Role: Principal Investigator
    The role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathology
    NIH RF1AG039452Aug 1, 2011 - Jan 31, 2024
    Role: Principal Investigator
    Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrier
    NIH R01NS034467Sep 1, 1995 - Feb 28, 2025
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain repair mechanisms after cell therapy for stroke. Brain. 2024 Oct 03; 147(10):3286-3305. Rust R, Nih LR, Liberale L, Yin H, El Amki M, Ong LK, Zlokovic BV. PMID: 38916992; PMCID: PMC11449145.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    2. Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Brain Imaging Behav. 2024 Sep 10. Contreras JA, Fujisaki K, Ortega NE, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic BV, Toga AW, Pa J. PMID: 39254921.
      View in: PubMed   Mentions:    Fields:    
    3. A molecular brain atlas reveals cellular shifts during the repair phase of stroke. bioRxiv. 2024 Aug 22. Weber RZ, Buil BA, Rentsch NH, Bosworth A, Zhang M, Kisler K, Tackenberg C, Zlokovic BV, Rust R. PMID: 39229128; PMCID: PMC11370539.
      View in: PubMed   Mentions:
    4. Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins. bioRxiv. 2024 Aug 17. Thorwald MA, Godoy-Lugo JA, Santa Maria N, Chakhoyan A, O'Day P, Jacobs R, Zlokovic B, Finch C. PMID: 39211245; PMCID: PMC11361199.
      View in: PubMed   Mentions:
    5. Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2024 Jun; 30(6):1792. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 38509330.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney. J Clin Invest. 2024 Apr 10; 134(11). Gyarmati G, Shroff UN, Riquier-Brison A, Desposito D, Ju W, Stocker SD, Izuhara A, Deepak S, Becerra Calderon A, Burford JL, Kadoya H, Moon JY, Chen Y, Rinschen MM, Ahmadi N, Lau L, Biemesderfer D, James AW, Minichiello L, Zlokovic BV, Gill IS, Kretzler M, Peti-Peterdi J. PMID: 38598837; PMCID: PMC11142747.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2024 Apr 03; 15(1):2882. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 38570509; PMCID: PMC10991248.
      View in: PubMed   Mentions:    Fields:    
    8. Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr; 30(4):1215. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 38580816; PMCID: PMC11036445.
      View in: PubMed   Mentions:    Fields:    
    9. Retraction Note: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2024 Apr; 30(4):1214. Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. PMID: 38509331.
      View in: PubMed   Mentions:    Fields:    
    10. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2024 Mar 22; 19(1):27. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 38519970; PMCID: PMC10960407.
      View in: PubMed   Mentions:    Fields:    
    11. Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis. Cereb Circ Cogn Behav. 2024; 6:100216. Hansra GK, Jayasena T, Hosoki S, Poljak A, Lam BCP, Rust R, Sagare A, Zlokovic B, Thalamuthu A, Sachdev PS. PMID: 38510579; PMCID: PMC10951911.
      View in: PubMed   Mentions: 4  
    12. Erratum: "Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model". Environ Health Perspect. 2024 Feb; 132(2):29001. Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, Morgan TE, Finch CE, Mack WJ. PMID: 38358996; PMCID: PMC10868724.
      View in: PubMed   Mentions:    Fields:    
    13. The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. Nat Commun. 2024 Feb 03; 15(1):1037. Wang XF, Vigouroux R, Syonov M, Baglaenko Y, Nikolakopoulou AM, Ringuette D, Rus H, DiStefano PV, Dufour S, Shabanzadeh AP, Lee S, Mueller BK, Charish J, Harada H, Fish JE, Wither J, Wälchli T, Cloutier JF, Zlokovic BV, Carlen PL, Monnier PP. PMID: 38310100; PMCID: PMC10838306.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024 Jan; 27(1):208. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 37985802.
      View in: PubMed   Mentions:    Fields:    
    15. Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. Neuron. 2023 Dec 20; 111(24):4116. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. PMID: 38135361.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    16. Molecular biomarkers for vascular cognitive impairment and dementia. Nat Rev Neurol. 2023 12; 19(12):737-753. Hosoki S, Hansra GK, Jayasena T, Poljak A, Mather KA, Catts VS, Rust R, Sagare A, Kovacic JC, Brodtmann A, Wallin A, Zlokovic BV, Ihara M, Sachdev PS. PMID: 37957261.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    17. Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging. Neuron. 2023 Oct 04; 111(19):3131-3132. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 37797582; PMCID: PMC10765950.
      View in: PubMed   Mentions: 1     Fields:    
    18. Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2023 Oct 03; 14(1):6151. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 37788984; PMCID: PMC10547792.
      View in: PubMed   Mentions: 1     Fields:    
    19. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2023 Aug 29; 42(8):113050. Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. PMID: 37597183; PMCID: PMC10521935.
      View in: PubMed   Mentions:    Fields:    
    20. Magnetic resonance imaging of white matter response to diesel exhaust particles. Res Sq. 2023 Jul 18. Chakhoyan A, Shkrkova K, Sizdahkhani S, Huuskonen MT, Lamorie-Foote K, Diaz A, Chen S, Liu Q, D'Agostino C, Zhang H, Mack WJ, Sioutas C, Finch CE, Zlokovic B, Mack WJ. PMID: 37503159; PMCID: PMC10371072.
      View in: PubMed   Mentions:
    21. Analysis of brain edema in RHAPSODY. Int J Stroke. 2024 Jan; 19(1):68-75. Schleicher RL, Vorasayan P, McCabe ME, Bevers MB, Davis TP, Griffin JH, Hinduja A, Jadhav AP, Lee JM, Sawyer RN, Zlokovic BV, Sheth KN, Fedler JK, Lyden P, Kimberly WT, NN104 Investigators. PMID: 37382409; PMCID: PMC10789908.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2023 May; 617(7961):E12. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 37142785.
      View in: PubMed   Mentions:    Fields:    
    23. Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Res Sq. 2023 Mar 07. Contreras JA, Fujisaki K, Ortega N, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic B, Toga AW, Pa J. PMID: 36945439; PMCID: PMC10029080.
      View in: PubMed   Mentions:
    24. Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 Feb 24; 18(1):14. Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36829231; PMCID: PMC9960439.
      View in: PubMed   Mentions:    Fields:    
    25. Characterization of spastic paraplegia in a family with a novel PSEN1 mutation. Brain Commun. 2023; 5(2):fcad030. Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, Magaki S, Guzman S, Sagare A, Zlokovic B, Cederbaum S, Nelson S, Sheikh-Bahaei N, Chui HC, Chávez-Gutiérrez L, Vinters HV. PMID: 36895955; PMCID: PMC9991506.
      View in: PubMed   Mentions: 2  
    26. PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell. 2023 02 16; 186(4):786-802.e28. Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. PMID: 36754049; PMCID: PMC10062012.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    27. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 01 27; 18(1):7. Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36707892; PMCID: PMC9883925.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    28. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimers Dement. 2023 03; 19(3):1041-1066. Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. PMID: 36479795; PMCID: PMC10576546.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    29. Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling. Front Cell Neurosci. 2022; 16:1078919. Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. PMID: 36523817; PMCID: PMC9746286.
      View in: PubMed   Mentions: 1  
    30. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2022 Nov 03; 17(1):71. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 36329501; PMCID: PMC9632156.
      View in: PubMed   Mentions: 2     Fields:    
    31. A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. J Exp Med. 2022 11 07; 219(11). Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV. PMID: 36040482; PMCID: PMC9435921.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    32. Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. J Cereb Blood Flow Metab. 2022 10; 42(10):1813-1826. Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. PMID: 35673963; PMCID: PMC9536121.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    33. How the brain regulates its own immune system. Nat Neurosci. 2022 05; 25(5):532-534. Kisler K, Zlokovic BV. PMID: 35501381.
      View in: PubMed   Mentions: 6     Fields:    
    34. Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions. Geroscience. 2022 06; 44(3):1339-1351. Montagne A, Barnes SR, Nation DA, Kisler K, Toga AW, Zlokovic BV. PMID: 35469116; PMCID: PMC9213625.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    35. The small HDL particle hypothesis of Alzheimer's disease. Alzheimers Dement. 2023 02; 19(2):391-404. Martinez AE, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, Rees JC, Parks BA, Gardner MS, King SM, Collier TS, Harrington MG, Sweeney MD, Wang X, Zlokovic BV, Joe E, Nation DA, Schneider LS, Chui HC, Barr JR, Han SD, Krauss RM, Yassine HN. PMID: 35416404; PMCID: PMC10563117.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    36. Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119. Zhao Q, Dai W, Chen HY, Jacobs RE, Zlokovic BV, Lund BT, Montagne A, Bonnin A. PMID: 35377817; PMCID: PMC9169666.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    37. 3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice. Front Neurosci. 2022; 16:841916. Wang Y, Kisler K, Nikolakopoulou AM, Fernandez JA, Griffin JH, Zlokovic BV. PMID: 35431776; PMCID: PMC9005806.
      View in: PubMed   Mentions: 11  
    38. A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022 03 04; 375(6584):eabi7377. Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ. PMID: 35084939; PMCID: PMC8995178.
      View in: PubMed   Mentions: 108     Fields:    Translation:HumansCells
    39. Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease. Nat Cardiovasc Res. 2022 Feb; 1(2):108-115. Barisano G, Montagne A, Kisler K, Schneider JA, Wardlaw JM, Zlokovic BV. PMID: 35450117; PMCID: PMC9017393.
      View in: PubMed   Mentions: 44  
    40. Brain barriers and their potential role in migraine pathophysiology. J Headache Pain. 2022 Jan 26; 23(1):16. Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M, Ashina M. PMID: 35081902; PMCID: PMC8903554.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    41. Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma? Cell Rep Med. 2021 12 21; 2(12):100481. Zhao Z, Zlokovic BV. PMID: 35028620; PMCID: PMC8715060.
      View in: PubMed   Mentions: 1     Fields:    
    42. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. J Exp Med. 2022 01 03; 219(1). Huuskonen MT, Wang Y, Nikolakopoulou AM, Montagne A, Dai Z, Lazic D, Sagare AP, Zhao Z, Fernandez JA, Griffin JH, Zlokovic BV. PMID: 34846535; PMCID: PMC8635278.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    43. Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion. Front Immunol. 2021; 12:785519. Huuskonen MT, Liu Q, Lamorie-Foote K, Shkirkova K, Connor M, Patel A, Montagne A, Baertsch H, Sioutas C, Morgan TE, Finch CE, Zlokovic BV, Mack WJ. PMID: 34868068; PMCID: PMC8635097.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Microglia have a grip on brain microvasculature. Nat Commun. 2021 09 06; 12(1):5290. Kisler K, Nikolakopoulou AM, Zlokovic BV. PMID: 34489417; PMCID: PMC8421408.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    45. Reply to: Rethink the classical view of cerebrospinal fluid production. Nat Rev Neurol. 2021 09; 17(9):590-591. Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Charpak S, Smith KJ, Black SE. PMID: 34253900.
      View in: PubMed   Mentions: 2     Fields:    
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    101. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714; PMCID: PMC6112156.
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    102. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711; PMCID: PMC5840035.
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    103. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 03; 14(3):133-150. Sweeney MD, Sagare AP, Zlokovic BV. PMID: 29377008; PMCID: PMC5829048.
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    104. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PMID: 29343482; PMCID: PMC5855020.
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    105. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. PMID: 29192539; PMCID: PMC6365610.
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    106. Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169. Montagne A, Zhao Z, Zlokovic BV. PMID: 29061693; PMCID: PMC5679168.
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    107. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278; PMCID: PMC5857404.
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    108. Role of clusterin in the brain vascular clearance of amyloid-β. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. Nelson AR, Sagare AP, Zlokovic BV. PMID: 28765369; PMCID: PMC5565473.
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    109. Remote control of BBB: A tale of exosomes and microRNA. Cell Res. 2017 07; 27(7):849-850. Zhao Z, Zlokovic BV. PMID: 28674430; PMCID: PMC5518990.
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    110. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434. Kisler K, Nelson AR, Montagne A, Zlokovic BV. PMID: 28515434; PMCID: PMC5759779.
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    111. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017 May 01; 14(1):12. Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. PMID: 28457227; PMCID: PMC5410699.
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    112. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. PLoS One. 2017; 12(4):e0176225. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. PMID: 28441414; PMCID: PMC5404855.
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    113. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240; PMCID: PMC5323291.
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    114. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. PMID: 27758767; PMCID: PMC5119536.
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    115. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. PMID: 27548576; PMCID: PMC5215920.
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    116. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 2016 11 03; 19(5):663-671. Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. PMID: 27524440; PMCID: PMC5144538.
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    119. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. PMID: 27038189; PMCID: PMC5283382.
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    120. Clearance systems in the brain--implications for Alzheimer diseaser. Nat Rev Neurol. 2016 Apr; 12(4):248. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. PMID: 27020556.
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    121. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. PMID: 26941593; PMCID: PMC4761864.
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    123. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. PMID: 25757756; PMCID: PMC4758554.
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    124. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4. Montagne A, Toga AW, Zlokovic BV. PMID: 26524294; PMCID: PMC4736734.
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    125. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900. Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. PMID: 26705676; PMCID: PMC4821735.
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    126. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 2015 Nov 19; 163(5):1064-1078. Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. PMID: 26590417; PMCID: PMC4655822.
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    127. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101. Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. PMID: 26407747; PMCID: PMC4631673.
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    128. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. Amar AP, Griffin JH, Zlokovic BV. PMID: 26388732; PMCID: PMC4556986.
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    130. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. PMID: 26236233; PMCID: PMC4502358.
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    132. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. PMID: 26076957; PMCID: PMC4466867.
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    133. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850; PMCID: PMC4482781.
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    137. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. PMID: 25859293; PMCID: PMC4386863.
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    139. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. PMID: 25611508; PMCID: PMC4350773.
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    140. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 2015 Jun; 11(6):710-7. Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC. PMID: 25510382; PMCID: PMC4731036.
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    142. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014 Sep 05; 5:4820. Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. PMID: 25190485; PMCID: PMC4157316.
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    144. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86. Winkler EA, Sagare AP, Zlokovic BV. PMID: 24946075; PMCID: PMC4423607.
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    146. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. PMID: 24591593; PMCID: PMC3964055.
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    148. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. PMID: 24159062; PMCID: PMC3912991.
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    149. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200. Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. PMID: 24030206; PMCID: PMC4047029.
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    150. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. PMID: 23580652; PMCID: PMC3663536.
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    154. A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4. Zlokovic BV. PMID: 23441580.
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    169. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92. Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. PMID: 22406537; PMCID: PMC3314449.
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    170. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. PMID: 22632606; PMCID: PMC3472038.
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    171. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. Zlokovic BV. PMID: 22048062; PMCID: PMC4036520.
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    172. Central nervous system pericytes in health and disease. Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. Winkler EA, Bell RD, Zlokovic BV. PMID: 22030551; PMCID: PMC4020628.
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    173. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res. 2011 Jul; 89(7):967-8. Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. PMID: 21544850.
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    174. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. Zhong Z, Winkler EA, Zlokovic BV. PMID: 21413850.
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    175. Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell. 2011 Mar 15; 20(3):279-80. Winkler EA, Bell RD, Zlokovic BV. PMID: 21397835.
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    177. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21291561; PMCID: PMC3042387.
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    179. Methamphetamine causes sustained depression in cerebral blood flow. Brain Res. 2011 Feb 10; 1373:91-100. Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. PMID: 21156163; PMCID: PMC3026925.
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    180. Neurodegeneration and the neurovascular unit. Nat Med. 2010 Dec; 16(12):1370-1. Zlokovic BV. PMID: 21135839.
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    181. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21084607; PMCID: PMC3012432.
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    182. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 21040844; PMCID: PMC3056408.
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    183. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. PMID: 20854368; PMCID: PMC2972355.
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    184. Pericyte constriction after stroke: the jury is still out. Nat Med. 2010 Sep; 16(9):959; author reply 960. Vates GE, Takano T, Zlokovic B, Nedergaard M. PMID: 20823870.
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    185. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener. 2010 Aug 25; 5:32. Winkler EA, Bell RD, Zlokovic BV. PMID: 20738866; PMCID: PMC2936891.
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    187. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72. Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. PMID: 20348395; PMCID: PMC2890172.
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    188. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. PMID: 20043896; PMCID: PMC2861918.
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    189. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. PMID: 20023547; PMCID: PMC2800370.
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    190. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. PMID: 19841542; PMCID: PMC2769191.
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    191. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. PMID: 19815836; PMCID: PMC2791928.
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    192. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009 Jul; 118(1):103-13. Bell RD, Zlokovic BV. PMID: 19319544; PMCID: PMC2853006.
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    196. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53. Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 19098903; PMCID: PMC2654279.
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    198. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. PMID: 19036971; PMCID: PMC2742231.
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    199. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. PMID: 19033669; PMCID: PMC2582453.
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    200. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. PMID: 18841163; PMCID: PMC2895315.
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    201. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):409-14. Zlokovic BV. PMID: 18625452; PMCID: PMC2536515.
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    202. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. PMID: 18451334; PMCID: PMC2574857.
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    203. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. PMID: 18344992; PMCID: PMC2895310.
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    204. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24; 57(2):178-201. Zlokovic BV. PMID: 18215617.
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    205. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5. Deane R, Sagare A, Zlokovic BV. PMID: 18673201; PMCID: PMC2895311.
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    206. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71. Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. PMID: 17971789; PMCID: PMC2744583.
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    207. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. PMID: 17694066; PMCID: PMC2936449.
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    208. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):191-7. Deane R, Zlokovic BV. PMID: 17430246.
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    209. Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7. Thiyagarajan M, Cheng T, Zlokovic BV. PMID: 17272817.
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    210. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:40-50. Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. PMID: 17413008.
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    211. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 17215356; PMCID: PMC1783398.
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    212. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. Mosnier LO, Zlokovic BV, Griffin JH. PMID: 17110453.
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    213. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. PMID: 17077814; PMCID: PMC2853021.
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    214. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 17072311.
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    215. Remodeling after stroke. Nat Med. 2006 Apr; 12(4):390-1. Zlokovic BV. PMID: 16598283.
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    216. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 16464623.
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    217. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. PMID: 16354907; PMCID: PMC6726020.
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    218. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. PMID: 16239972; PMCID: PMC1257538.
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    219. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. PMID: 16130108.
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    220. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. PMID: 16116430.
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    221. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr; 28(4):202-8. Zlokovic BV. PMID: 15808355.
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    222. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. PMID: 15743889.
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    225. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. Deane R, Wu Z, Zlokovic BV. PMID: 15459432.
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    226. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. PMID: 15325132.
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    227. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. PMID: 15294142.
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    228. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16. Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. PMID: 15183014.
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    229. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 15118526.
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    230. Clearing amyloid through the blood-brain barrier. J Neurochem. 2004 May; 89(4):807-11. Zlokovic BV. PMID: 15140180.
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    231. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 07; 279(19):20296-306. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. PMID: 14985348.
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    233. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004 Feb; 88(4):813-20. Deane R, Zheng W, Zlokovic BV. PMID: 14756801; PMCID: PMC3980859.
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    234. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. Wu Z, Hofman FM, Zlokovic BV. PMID: 14583404.
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    235. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. PMID: 12808450.
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    239. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. PMID: 12563316.
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    240. Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. Amar AP, Zlokovic BV, Apuzzo ML. PMID: 12535371.
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    241. Current treatments and therapeutic targets in Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7. Zlokovic BV. PMID: 12453670.
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    243. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. PMID: 12176746.
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    244. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. Griffin JH, Zlokovic B, Fernández JA. PMID: 12124682.
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    245. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun; 38(6):303-13. Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. PMID: 12529925.
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    246. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target. 2002 Jun; 10(4):359-68. Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. PMID: 12164385.
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    247. The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2002 Jun; 4(3):217-23. Grammas P, Yamada M, Zlokovic B. PMID: 12226540.
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    248. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun; 23(3):405-12. Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. PMID: 11959403.
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    249. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2001 May; 48(5):1196-7. Zlokovic BV, Cox C. PMID: 11334298.
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    250. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. PMID: 11311331.
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    251. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. PMID: 11282913.
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    252. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001 Jan; 48(1):151-7. MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. PMID: 11152340.
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    253. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec; 106(12):1489-99. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. PMID: 11120756; PMCID: PMC387254.
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    254. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81. Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. PMID: 11078691.
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    255. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech. 2000 Aug 15; 50(4):305-15. Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. PMID: 10936885.
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    256. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. PMID: 10899440.
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    257. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9. Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. PMID: 10888892.
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    258. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 01; 348 Pt 2:359-65. Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. PMID: 10816430; PMCID: PMC1221074.
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    259. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. PMID: 10894183.
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    260. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000 Apr; 141(4):1434-41. Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. PMID: 10746647.
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    261. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999 Dec 01; 344 Pt 2:375-83. Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. PMID: 10567218; PMCID: PMC1220653.
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    262. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. PMID: 10559029.
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    263. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. PMID: 10515502.
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    264. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett. 1999 Sep 10; 272(2):127-30. Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. PMID: 10507558.
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    265. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res. 1999 Sep; 16(9):1360-5. Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. PMID: 10496650.
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    266. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea. 1999 May; 18(3):321-7. Kannan R, Mackic JB, Zlokovic BV. PMID: 10336036.
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    267. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol. 1999 May; 157(1):194-201. Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. PMID: 10222122.
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    268. Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec 01; 92(5):213-9. Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. PMID: 9851812.
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    269. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. PMID: 9848858.
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    270. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery. 1998 Oct; 43(4):909-13. Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. PMID: 9766319.
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    271. Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998 Oct; 43(4):877-8. Zlokovic BV, Apuzzo ML. PMID: 9766315.
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    272. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug 15; 91(4):191-7. Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. PMID: 9736422.
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    273. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. PMID: 9710442; PMCID: PMC508936.
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    274. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther. 1998 May 01; 9(7):989-95. LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. PMID: 9607410.
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    275. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan; 70(1):210-5. Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. PMID: 9422364.
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    276. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. Lavine SD, Hofman FM, Zlokovic BV. PMID: 9428305.
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    277. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. J Neurosurg. 1997 Nov; 87(5):731-7. Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. PMID: 9347982.
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    278. Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. PMID: 9409303.
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    279. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem. 1997 Nov; 69(5):1995-2004. Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. PMID: 9349544.
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    280. Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 1997 Jun 15; 2(6):e5. Zlokovic BV. PMID: 15099052.
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    281. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 9227280.
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    282. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs. Curr Eye Res. 1997 Apr; 16(4):365-71. Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. PMID: 9134326.
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    283. Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. Zlokovic BV, Apuzzo ML. PMID: 9092853.
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    284. Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. Zlokovic BV, Apuzzo ML. PMID: 9092854.
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    285. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. PMID: 9040492.
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    286. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharm Res. 1997 Jan; 14(1):80-5. Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. PMID: 9034225.
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    287. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiol Dis. 1997; 4(1):23-6. Zlokovic B. PMID: 9258908.
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    288. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. PMID: 8843923.
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    289. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. PMID: 8633046; PMCID: PMC39517.
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    290. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. PMID: 8621654.
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    291. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke. 1996 Apr; 27(4):712-9. Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. PMID: 8614937.
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    292. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. PMID: 8710175.
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    293. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5. Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. PMID: 8932451.
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    294. Cellular uptake and transport of methylprednisolone at the blood-brain barrier. Neurosurgery. 1996 Feb; 38(2):348-54. Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. PMID: 8869063.
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    295. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 8674510.
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    296. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci. 1996; 59(18):1483-97. Zlokovic BV. PMID: 8890929.
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    297. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 1995 Nov; 37(5):955-61. Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. PMID: 8559345.
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    298. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. PMID: 7591644.
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    299. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res. 1995 Oct; 12(10):1395-406. Zlokovic BV. PMID: 8584471.
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    300. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. PMID: 7635653.
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    301. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. PMID: 8642902.
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    302. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism. Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic LM. PMID: 7549442.
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    303. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. PMID: 7802679.
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    304. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. PMID: 7859824.
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    305. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. PMID: 8198602.
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    306. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. PMID: 8147886.
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    307. Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. PMID: 8125742.
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    308. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. PMID: 8280117.
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    309. The blood-brain barrier in vitro: recent progress. Neurochem Int. 1993 Dec; 23(6):523. Zlokovic BV. PMID: 8281120.
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    310. Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25. Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. PMID: 8385133.
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    311. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. PMID: 8384107.
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    312. Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. PMID: 8384106.
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    313. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. PMID: 8392783.
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    314. A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Exp Eye Res. 1993 Jan; 56(1):45-50. Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. PMID: 8432334.
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    315. Blood-brain transport of vasopressin. Adv Exp Med Biol. 1993; 331:143-7. Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. PMID: 8333329.
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    316. Differential brain penetration of cerebroprotective drugs. Adv Exp Med Biol. 1993; 331:117-20. Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. PMID: 8333325.
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    317. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res. 1992 Sep 11; 590(1-2):213-8. Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. PMID: 1422832.
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    318. An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Exp Eye Res. 1992 Mar; 54(3):471-7. Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. PMID: 1381681.
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    319. Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse. NIDA Res Monogr. 1992; 120:26-42. Zlokovic BV, McComb JG, Perlmutter L, Weiss MH, Davson H. PMID: 1501689.
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    320. Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 1991 Nov-Dec; 32(6):783-90. Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. PMID: 1743149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    321. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. PMID: 1902062.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    322. Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. PMID: 1899978.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    323. The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta. Agents Actions Suppl. 1991; 33:283-7. Rosic M, Collis CS, Anjelkovic IZ, Segal MB, Djuric D, Zlokovic BV. PMID: 1647128.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    324. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem. 1990 Oct; 55(4):1222-30. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, Greenwood J. PMID: 2398356.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    325. Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. PMID: 2364078.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    326. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. Segal MB, Preston JE, Collis CS, Zlokovic BV. PMID: 2186633.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    327. Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep. Endocrinol Exp. 1990 Mar; 24(1-2):29-36. Segal MB, Preston JE, Zlokovic B. PMID: 2361466.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    328. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990 Mar; 107(3):263-70. Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. PMID: 1689666.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    329. Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers. Endocrinol Exp. 1990 Mar; 24(1-2):9-17. Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG. PMID: 2193795.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    330. Immunoneurology: a serum protein afferent limb to the CNS. Adv Exp Med Biol. 1990; 274:345-70. Kozlowski GP, Nilaver G, Zlokovic BV. PMID: 2239432.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    331. Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. J Neurol Sci. 1989 Dec; 94(1-3):41-50. Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. PMID: 2515257.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    332. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem. 1989 Nov; 53(5):1333-40. Zlokovic BV, Mackic JB, Djuricic B, Davson H. PMID: 2795003.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    333. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. PMID: 2548879.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    334. Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis. 1989 Mar; 4(1):33-40. Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H, et al. PMID: 2495422.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    335. Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metab Brain Dis. 1989 Mar; 4(1):9-15. Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. PMID: 2495423.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    336. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989 Mar-Apr; 10(2):249-54. Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. PMID: 2547200.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    337. Neutral amino acid uptake by the isolated perfused sheep choroid plexus. J Physiol. 1989 Jan; 408:31-43. Preston JE, Segal MB, Walley GJ, Zlokovic BV. PMID: 2506339; PMCID: PMC1190388.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    338. Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem. 1988 Jul; 51(1):252-7. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3132534.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    339. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1988 May-Jun; 9(3):533-8. Zlokovic BV, Segal MB, Davson H, Jankov RM. PMID: 3420012.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    340. Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. Zlokovic BV, Andjelkovic IZ. PMID: 2460051.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    341. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept. 1988 Jan; 20(1):33-44. Zlokovic BV, Segal MB, Davson H, Mitrovic DM. PMID: 3127863.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    342. The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Exp Neurol. 1987 Nov; 98(2):436-52. Zlokovic BV, Davson H, Preston JE, Segal MB. PMID: 2444450.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    343. Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem. 1987 Jul; 49(1):310-5. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3585338.
      View in: PubMed   Mentions: 38     Fields:    
    344. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J Neurochem. 1986 May; 46(5):1444-51. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM. PMID: 3083044.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    345. Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 1985 Dec 09; 358(1-2):191-9. Zlokovic BV, Segal MB, Begley DJ, Davson H, Rakic L. PMID: 3935272.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    346. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. Mann GE, Zlokovic BV, Yudilevich DL. PMID: 4041458.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    347. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985 Jun 10; 336(1):125-32. Zlokovic BV, Begley DJ, Chain-Eliash DG. PMID: 3891014.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    348. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res. 1983 Jul 18; 271(1):65-71. Zlokovic BV, Begley DJ, Chain DG. PMID: 6883121.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    349. Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol. 1982 Jul; 76(3):483-9. Andjelkovic I, Zlokovic B. PMID: 6179557; PMCID: PMC2071802.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
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