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Brain repair mechanisms after cell therapy for stroke. Brain. 2024 Oct 03; 147(10):3286-3305.
Rust R, Nih LR, Liberale L, Yin H, El Amki M, Ong LK, Zlokovic BV. PMID: 38916992; PMCID: PMC11449145.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Brain Imaging Behav. 2024 Sep 10.
Contreras JA, Fujisaki K, Ortega NE, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic BV, Toga AW, Pa J. PMID: 39254921.
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A molecular brain atlas reveals cellular shifts during the repair phase of stroke. bioRxiv. 2024 Aug 22.
Weber RZ, Buil BA, Rentsch NH, Bosworth A, Zhang M, Kisler K, Tackenberg C, Zlokovic BV, Rust R. PMID: 39229128; PMCID: PMC11370539.
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Iron chelation by oral deferoxamine treatment decreased brain iron and iron signaling proteins. bioRxiv. 2024 Aug 17.
Thorwald MA, Godoy-Lugo JA, Santa Maria N, Chakhoyan A, O'Day P, Jacobs R, Zlokovic B, Finch C. PMID: 39211245; PMCID: PMC11361199.
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Editorial Expression of Concern: Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2024 Jun; 30(6):1792.
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 38509330.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Neuronally differentiated macula densa cells regulate tissue remodeling and regeneration in the kidney. J Clin Invest. 2024 Apr 10; 134(11).
Gyarmati G, Shroff UN, Riquier-Brison A, Desposito D, Ju W, Stocker SD, Izuhara A, Deepak S, Becerra Calderon A, Burford JL, Kadoya H, Moon JY, Chen Y, Rinschen MM, Ahmadi N, Lau L, Biemesderfer D, James AW, Minichiello L, Zlokovic BV, Gill IS, Kretzler M, Peti-Peterdi J. PMID: 38598837; PMCID: PMC11142747.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2024 Apr 03; 15(1):2882.
Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 38570509; PMCID: PMC10991248.
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PubMed Mentions: Fields:
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Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr; 30(4):1215.
Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 38580816; PMCID: PMC11036445.
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PubMed Mentions: Fields:
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Retraction Note: Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2024 Apr; 30(4):1214.
Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. PMID: 38509331.
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PubMed Mentions: Fields:
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Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2024 Mar 22; 19(1):27.
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 38519970; PMCID: PMC10960407.
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PubMed Mentions: Fields:
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Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis. Cereb Circ Cogn Behav. 2024; 6:100216.
Hansra GK, Jayasena T, Hosoki S, Poljak A, Lam BCP, Rust R, Sagare A, Zlokovic B, Thalamuthu A, Sachdev PS. PMID: 38510579; PMCID: PMC10951911.
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PubMed Mentions:
4
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Erratum: "Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model". Environ Health Perspect. 2024 Feb; 132(2):29001.
Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, Morgan TE, Finch CE, Mack WJ. PMID: 38358996; PMCID: PMC10868724.
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PubMed Mentions: Fields:
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The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity. Nat Commun. 2024 Feb 03; 15(1):1037.
Wang XF, Vigouroux R, Syonov M, Baglaenko Y, Nikolakopoulou AM, Ringuette D, Rus H, DiStefano PV, Dufour S, Shabanzadeh AP, Lee S, Mueller BK, Charish J, Harada H, Fish JE, Wither J, Wälchli T, Cloutier JF, Zlokovic BV, Carlen PL, Monnier PP. PMID: 38310100; PMCID: PMC10838306.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024 Jan; 27(1):208.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 37985802.
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PubMed Mentions: Fields:
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Activated Protein C Prevents Neuronal Apoptosis via Protease Activated Receptors 1 and 3. Neuron. 2023 Dec 20; 111(24):4116.
Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. PMID: 38135361.
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PubMed Mentions: Fields:
Translation:
Cells
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Molecular biomarkers for vascular cognitive impairment and dementia. Nat Rev Neurol. 2023 12; 19(12):737-753.
Hosoki S, Hansra GK, Jayasena T, Poljak A, Mather KA, Catts VS, Rust R, Sagare A, Kovacic JC, Brodtmann A, Wallin A, Zlokovic BV, Ihara M, Sachdev PS. PMID: 37957261.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging. Neuron. 2023 Oct 04; 111(19):3131-3132.
Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 37797582; PMCID: PMC10765950.
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PubMed Mentions:
1 Fields:
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Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2023 Oct 03; 14(1):6151.
Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 37788984; PMCID: PMC10547792.
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PubMed Mentions:
1 Fields:
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TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2023 Aug 29; 42(8):113050.
Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. PMID: 37597183; PMCID: PMC10521935.
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PubMed Mentions: Fields:
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Magnetic resonance imaging of white matter response to diesel exhaust particles. Res Sq. 2023 Jul 18.
Chakhoyan A, Shkrkova K, Sizdahkhani S, Huuskonen MT, Lamorie-Foote K, Diaz A, Chen S, Liu Q, D'Agostino C, Zhang H, Mack WJ, Sioutas C, Finch CE, Zlokovic B, Mack WJ. PMID: 37503159; PMCID: PMC10371072.
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PubMed Mentions:
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Analysis of brain edema in RHAPSODY. Int J Stroke. 2024 Jan; 19(1):68-75.
Schleicher RL, Vorasayan P, McCabe ME, Bevers MB, Davis TP, Griffin JH, Hinduja A, Jadhav AP, Lee JM, Sawyer RN, Zlokovic BV, Sheth KN, Fedler JK, Lyden P, Kimberly WT, NN104 Investigators. PMID: 37382409; PMCID: PMC10789908.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2023 May; 617(7961):E12.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 37142785.
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PubMed Mentions: Fields:
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Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Res Sq. 2023 Mar 07.
Contreras JA, Fujisaki K, Ortega N, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic B, Toga AW, Pa J. PMID: 36945439; PMCID: PMC10029080.
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PubMed Mentions:
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Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 Feb 24; 18(1):14.
Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36829231; PMCID: PMC9960439.
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PubMed Mentions: Fields:
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Characterization of spastic paraplegia in a family with a novel PSEN1 mutation. Brain Commun. 2023; 5(2):fcad030.
Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, Magaki S, Guzman S, Sagare A, Zlokovic B, Cederbaum S, Nelson S, Sheikh-Bahaei N, Chui HC, Chávez-Gutiérrez L, Vinters HV. PMID: 36895955; PMCID: PMC9991506.
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PubMed Mentions:
2
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PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell. 2023 02 16; 186(4):786-802.e28.
Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. PMID: 36754049; PMCID: PMC10062012.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 01 27; 18(1):7.
Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36707892; PMCID: PMC9883925.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimers Dement. 2023 03; 19(3):1041-1066.
Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. PMID: 36479795; PMCID: PMC10576546.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling. Front Cell Neurosci. 2022; 16:1078919.
Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. PMID: 36523817; PMCID: PMC9746286.
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PubMed Mentions:
1
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Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2022 Nov 03; 17(1):71.
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 36329501; PMCID: PMC9632156.
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PubMed Mentions:
2 Fields:
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A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. J Exp Med. 2022 11 07; 219(11).
Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV. PMID: 36040482; PMCID: PMC9435921.
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PubMed Mentions:
21 Fields:
Translation:
HumansAnimalsCells
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Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging. J Cereb Blood Flow Metab. 2022 10; 42(10):1813-1826.
Monte B, Constantinou S, Koundal S, Lee H, Dai F, Gursky Z, Van Nostrand WE, Darbinyan A, Zlokovic BV, Wardlaw J, Benveniste H. PMID: 35673963; PMCID: PMC9536121.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimals
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How the brain regulates its own immune system. Nat Neurosci. 2022 05; 25(5):532-534.
Kisler K, Zlokovic BV. PMID: 35501381.
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PubMed Mentions:
6 Fields:
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Imaging subtle leaks in the blood-brain barrier in the aging human brain: potential pitfalls, challenges, and possible solutions. Geroscience. 2022 06; 44(3):1339-1351.
Montagne A, Barnes SR, Nation DA, Kisler K, Toga AW, Zlokovic BV. PMID: 35469116; PMCID: PMC9213625.
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PubMed Mentions:
24 Fields:
Translation:
Humans
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The small HDL particle hypothesis of Alzheimer's disease. Alzheimers Dement. 2023 02; 19(2):391-404.
Martinez AE, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, Rees JC, Parks BA, Gardner MS, King SM, Collier TS, Harrington MG, Sweeney MD, Wang X, Zlokovic BV, Joe E, Nation DA, Schneider LS, Chui HC, Barr JR, Han SD, Krauss RM, Yassine HN. PMID: 35416404; PMCID: PMC10563117.
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PubMed Mentions:
18 Fields:
Translation:
Humans
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Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2113310119.
Zhao Q, Dai W, Chen HY, Jacobs RE, Zlokovic BV, Lund BT, Montagne A, Bonnin A. PMID: 35377817; PMCID: PMC9169666.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice. Front Neurosci. 2022; 16:841916.
Wang Y, Kisler K, Nikolakopoulou AM, Fernandez JA, Griffin JH, Zlokovic BV. PMID: 35431776; PMCID: PMC9005806.
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PubMed Mentions:
11
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A single-cell atlas of the normal and malformed human brain vasculature. Science. 2022 03 04; 375(6584):eabi7377.
Winkler EA, Kim CN, Ross JM, Garcia JH, Gil E, Oh I, Chen LQ, Wu D, Catapano JS, Raygor K, Narsinh K, Kim H, Weinsheimer S, Cooke DL, Walcott BP, Lawton MT, Gupta N, Zlokovic BV, Chang EF, Abla AA, Lim DA, Nowakowski TJ. PMID: 35084939; PMCID: PMC8995178.
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PubMed Mentions:
108 Fields:
Translation:
HumansCells
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Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease. Nat Cardiovasc Res. 2022 Feb; 1(2):108-115.
Barisano G, Montagne A, Kisler K, Schneider JA, Wardlaw JM, Zlokovic BV. PMID: 35450117; PMCID: PMC9017393.
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PubMed Mentions:
44
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Brain barriers and their potential role in migraine pathophysiology. J Headache Pain. 2022 Jan 26; 23(1):16.
Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M, Ashina M. PMID: 35081902; PMCID: PMC8903554.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Can prehospital "plasma supplement" neutralize the systemic storm in severe trauma? Cell Rep Med. 2021 12 21; 2(12):100481.
Zhao Z, Zlokovic BV. PMID: 35028620; PMCID: PMC8715060.
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PubMed Mentions:
1 Fields:
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Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. J Exp Med. 2022 01 03; 219(1).
Huuskonen MT, Wang Y, Nikolakopoulou AM, Montagne A, Dai Z, Lazic D, Sagare AP, Zhao Z, Fernandez JA, Griffin JH, Zlokovic BV. PMID: 34846535; PMCID: PMC8635278.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion. Front Immunol. 2021; 12:785519.
Huuskonen MT, Liu Q, Lamorie-Foote K, Shkirkova K, Connor M, Patel A, Montagne A, Baertsch H, Sioutas C, Morgan TE, Finch CE, Zlokovic BV, Mack WJ. PMID: 34868068; PMCID: PMC8635097.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Microglia have a grip on brain microvasculature. Nat Commun. 2021 09 06; 12(1):5290.
Kisler K, Nikolakopoulou AM, Zlokovic BV. PMID: 34489417; PMCID: PMC8421408.
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PubMed Mentions:
17 Fields:
Translation:
Cells
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Reply to: Rethink the classical view of cerebrospinal fluid production. Nat Rev Neurol. 2021 09; 17(9):590-591.
Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Charpak S, Smith KJ, Black SE. PMID: 34253900.
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PubMed Mentions:
2 Fields:
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Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model. Environ Health Perspect. 2021 08; 129(8):87006.
Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, Morgan TE, Finch CE, Mack WJ. PMID: 34424052; PMCID: PMC8382048.
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PubMed Mentions:
15 Fields:
Translation:
AnimalsPHPublic Health
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Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure". J Magn Reson Imaging. 2021 11; 54(5):1527-1528.
Huuskonen MT, Barisano G, Chakhoyan A, Zlokovic BV. PMID: 34331486; PMCID: PMC8976593.
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PubMed Mentions: Fields:
Translation:
Humans
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On the intersection between systemic infection, brain vascular dysfunction and dementia. Brain. 2021 07 28; 144(6):1629-1631.
Huuskonen MT, Kisler K, Sagare AP, Zlokovic BV. PMID: 33974045; PMCID: PMC8320279.
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Translation:
Humans
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Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021 Jul; 1(7):624.
Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV. PMID: 37117809.
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PubMed Mentions:
2 Fields:
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APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021 06; 1(6):506-520.
Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV. PMID: 35291561; PMCID: PMC8920485.
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PubMed Mentions:
53 Fields:
Translation:
Animals
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Acetylated tau: A missing link between head injury and dementia. Med. 2021 06 11; 2(6):637-639.
Zhao Z, Zlokovic BV. PMID: 35590136.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021 04 05; 218(4).
Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. PMID: 33533918; PMCID: PMC7863706.
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PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques. Spinal Cord. 2021 Jun; 59(6):596-612.
Bakhsheshian J, Strickland BA, Mack WJ, Zlokovic BV. PMID: 33742118.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache. 2021 Mar; 61(3):536-545.
Cowan RP, Gross NB, Sweeney MD, Sagare AP, Montagne A, Arakaki X, Fonteh AN, Zlokovic BV, Pogoda JM, Harrington MG. PMID: 33724462; PMCID: PMC8023403.
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PubMed Mentions:
9 Fields:
Translation:
Humans
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Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation. Front Neurol. 2021; 12:593582.
Lyden PD, Pryor KE, Minigh J, Davis TP, Griffin JH, Levy H, Zlokovic BV. PMID: 33790846; PMCID: PMC8005555.
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PubMed Mentions:
9
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Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Brain Behav Immun. 2021 05; 94:299-307.
Albrecht DS, Sagare A, Pachicano M, Sweeney MD, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Morris JC, Benzinger T, Pa J. PMID: 33486003; PMCID: PMC8793040.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell. 2021 01 07; 184(1):243-256.e18.
Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. PMID: 33417861; PMCID: PMC7891303.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort. Front Neurosci. 2020; 14:571480.
Shao X, Jann K, Ma SJ, Yan L, Montagne A, Ringman JM, Zlokovic BV, Wang DJJ. PMID: 33328848; PMCID: PMC7733970.
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PubMed Mentions:
29
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Endothelial Tip Cell Finds Its Way with Piezo1. Neuron. 2020 10 14; 108(1):5-7.
Zhao Z, Zlokovic BV. PMID: 33058766; PMCID: PMC7737505.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid. J Neurosci. 2020 10 28; 40(44):8573-8586.
Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Conti P, Jann K, Pa J. PMID: 33046556; PMCID: PMC7605425.
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PubMed Mentions:
44 Fields:
Translation:
Humans
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Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020 12; 16(12):1714-1733.
Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Koenig JI, Corriveau RA, Fine L, Galis ZS, Reis J, Wright JD, Chen J. PMID: 33030307.
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PubMed Mentions:
83 Fields:
Translation:
Humans
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A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease. Transl Stroke Res. 2021 02; 12(1):15-30.
Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM. PMID: 32936435; PMCID: PMC7803876.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansAnimals
-
Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimers Dement (Amst). 2020; 12(1):e12053.
Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, Hawkes CA, Koronyo-Hamaoui M, Hainsworth AH, Holtzman D, Ihara M, Jefferson A, Kalaria RN, Kipps CM, Kanninen KM, Leinonen V, McLaurin J, Miners S, Malm T, Nicoll JAR, Piazza F, Paul G, Rich SM, Saito S, Shih A, Scholtzova H, Snyder H, Snyder P, Thormodsson FR, van Veluw SJ, Weller RO, Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A. PMID: 32775596; PMCID: PMC7396859.
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PubMed Mentions:
50
-
Therapeutic TVs for Crossing Barriers in the Brain. Cell. 2020 07 23; 182(2):267-269.
Zhao Z, Zlokovic BV. PMID: 32707092; PMCID: PMC7737504.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine. 2020 Sep; 59:102883.
Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. PMID: 32690472; PMCID: PMC7502665.
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PubMed Mentions:
47 Fields:
Translation:
Humans
-
Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(7):e0236379.
Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32663228; PMCID: PMC7360049.
View in:
PubMed Mentions:
3 Fields:
-
3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase. Stroke. 2020 07; 51(7):2236-2239.
Mukherjee P, Lyden P, Fernández JA, Davis TP, Pryor KE, Zlokovic BV, Griffin JH. PMID: 32568648; PMCID: PMC7380733.
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PubMed Mentions: Fields:
Translation:
Humans
-
Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature. Lab Anim (NY). 2020 06; 49(6):175-176.
Kisler K, Huuskonen MT, Zlokovic BV. PMID: 32424313.
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PubMed Mentions:
1 Fields:
Translation:
Animals
-
Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(5):e0232785.
Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32469871; PMCID: PMC7259639.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76.
Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954; PMCID: PMC7250000.
View in:
PubMed Mentions:
527 Fields:
Translation:
HumansCells
-
Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo. Front Aging Neurosci. 2020; 12:108.
Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. PMID: 32410982; PMCID: PMC7201096.
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PubMed Mentions:
40
-
A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020 06; 16(6):821-830.
Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. PMID: 32301266; PMCID: PMC7986963.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
-
Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020 03; 16(3):137-153.
Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE, colleagues from the Fondation Leducq Transatlantic Network of Excellence on the Role of the Perivasc. PMID: 32094487.
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PubMed Mentions:
285 Fields:
Translation:
HumansAnimals
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APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700.
Montagne A, Nation DA, Zlokovic BV. PMID: 32070225; PMCID: PMC7041876.
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PubMed Mentions:
11 Fields:
Translation:
Humans
-
Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020; 14:27.
Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. PMID: 32116568; PMCID: PMC7033444.
View in:
PubMed Mentions:
34
-
Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease. Neurobiol Dis. 2020 03; 136:104745.
Lazic D, Tesic V, Jovanovic M, Brkic M, Milanovic D, Zlokovic BV, Kanazir S, Perovic M. PMID: 31931140.
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PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 12; 15(12):1568-1575.
Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 31862169; PMCID: PMC6927478.
View in:
PubMed Mentions:
18 Fields:
Translation:
Humans
-
Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers. Neurobiol Aging. 2020 02; 86:112-122.
Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. PMID: 31870643; PMCID: PMC7205323.
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PubMed Mentions:
13 Fields:
Translation:
Humans
-
Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22; 1747493019871915.
Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. PMID: 31543058.
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PubMed Mentions:
8 Fields:
-
Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 10 03; 25(4):486-500.e9.
Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. PMID: 31523028; PMCID: PMC6778044.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5.
Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. PMID: 31310593; PMCID: PMC6693831.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 07; 15(7):961-984.
Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. PMID: 31327392; PMCID: PMC7001744.
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PubMed Mentions:
112 Fields:
Translation:
Humans
-
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098.
Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. PMID: 31235908; PMCID: PMC6668719.
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PubMed Mentions:
174 Fields:
Translation:
AnimalsCells
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Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis. Am J Physiol Heart Circ Physiol. 2019 08 01; 317(2):H255-H263.
Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ. PMID: 31125259; PMCID: PMC6732474.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS One. 2019; 14(5):e0216726.
Jovic M, Loncarevic-Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, Kanazir S. PMID: 31095617; PMCID: PMC6522015.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2019 04 09; 27(2):549-560.e6.
Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. PMID: 30970257; PMCID: PMC6485958.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76.
Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. PMID: 30661727; PMCID: PMC6377285.
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PubMed Mentions:
2 Fields:
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3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293.
Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. PMID: 30647119; PMCID: PMC6363429.
View in:
PubMed Mentions:
32 Fields:
Translation:
AnimalsCells
-
Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276.
Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 30643288; PMCID: PMC6367058.
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PubMed Mentions:
685 Fields:
Translation:
Humans
-
Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136.
Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators. PMID: 30450637; PMCID: PMC6342508.
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PubMed Mentions:
78 Fields:
Translation:
HumansCTClinical Trials
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Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167.
Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Al-Shahi Salman R, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. PMID: 30642436; PMCID: PMC6338083.
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PubMed Mentions:
302 Fields:
Translation:
Humans
-
Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 01 01; 99(1):21-78.
Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. PMID: 30280653; PMCID: PMC6335099.
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PubMed Mentions:
829 Fields:
Translation:
HumansAnimalsCells
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Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018 10 19; 13(1):57.
Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 30340601; PMCID: PMC6194676.
View in:
PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
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The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018 10; 21(10):1318-1331.
Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. PMID: 30250261; PMCID: PMC6198802.
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PubMed Mentions:
420 Fields:
Translation:
HumansAnimals
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Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res. 2018 09 01; 114(11):1462-1473.
Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM. PMID: 29726891; PMCID: PMC6455920.
View in:
PubMed Mentions:
154 Fields:
Translation:
HumansAnimals
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A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature. 2018 08; 560(7717):172-174.
Sweeney MD, Zlokovic BV. PMID: 30076374; PMCID: PMC6201839.
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PubMed Mentions:
16 Fields:
Translation:
Humans
-
Activated protein C, protease activated receptor 1, and neuroprotection. Blood. 2018 07 12; 132(2):159-169.
Griffin JH, Zlokovic BV, Mosnier LO. PMID: 29866816; PMCID: PMC6043978.
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PubMed Mentions:
71 Fields:
Translation:
HumansAnimalsCells
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Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. Neurosurgery. 2018 06 01; 82(6):770-780.
Netto JP, Iliff J, Stanimirovic D, Krohn KA, Hamilton B, Varallyay C, Gahramanov S, Daldrup-Link H, d'Esterre C, Zlokovic B, Sair H, Lee Y, Taheri S, Jain R, Panigrahy A, Reich DS, Drewes LR, Castillo M, Neuwelt EA. PMID: 28973554; PMCID: PMC6256943.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nat Protoc. 2018 06; 13(6):1377-1402.
Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadži S, Zlokovic BV. PMID: 29844521; PMCID: PMC6402338.
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PubMed Mentions:
23 Fields:
Translation:
Animals
-
Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2018 06; 38(6):973-979.
Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. PMID: 29611451; PMCID: PMC5998996.
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PubMed Mentions:
13 Fields:
Translation:
HumansCTClinical Trials
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Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325.
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714; PMCID: PMC6112156.
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PubMed Mentions:
294 Fields:
Translation:
HumansAnimalsCells
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Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337.
Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711; PMCID: PMC5840035.
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PubMed Mentions:
192 Fields:
Translation:
HumansAnimalsCells
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Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 03; 14(3):133-150.
Sweeney MD, Sagare AP, Zlokovic BV. PMID: 29377008; PMCID: PMC5829048.
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PubMed Mentions:
1116 Fields:
Translation:
Humans
-
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171.
Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PMID: 29343482; PMCID: PMC5855020.
View in:
PubMed Mentions:
59 Fields:
Translation:
AnimalsCells
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Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. J Cereb Blood Flow Metab. 2019 02; 39(2):240-250.
Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. PMID: 29192539; PMCID: PMC6365610.
View in:
PubMed Mentions:
44 Fields:
Translation:
AnimalsCells
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Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169.
Montagne A, Zhao Z, Zlokovic BV. PMID: 29061693; PMCID: PMC5679168.
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PubMed Mentions:
313 Fields:
Translation:
HumansAnimals
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Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301.
Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278; PMCID: PMC5857404.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Role of clusterin in the brain vascular clearance of amyloid-β. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682.
Nelson AR, Sagare AP, Zlokovic BV. PMID: 28765369; PMCID: PMC5565473.
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PubMed Mentions:
49 Fields:
Translation:
Humans
-
Remote control of BBB: A tale of exosomes and microRNA. Cell Res. 2017 07; 27(7):849-850.
Zhao Z, Zlokovic BV. PMID: 28674430; PMCID: PMC5518990.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimalsCells
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Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434.
Kisler K, Nelson AR, Montagne A, Zlokovic BV. PMID: 28515434; PMCID: PMC5759779.
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PubMed Mentions:
517 Fields:
Translation:
Humans
-
NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017 May 01; 14(1):12.
Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. PMID: 28457227; PMCID: PMC5410699.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
-
Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. PLoS One. 2017; 12(4):e0176225.
Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. PMID: 28441414; PMCID: PMC5404855.
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PubMed Mentions:
63 Fields:
Translation:
AnimalsCells
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Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416.
Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240; PMCID: PMC5323291.
View in:
PubMed Mentions:
243 Fields:
Translation:
AnimalsCells
-
2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151.
Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. PMID: 27758767; PMCID: PMC5119536.
View in:
PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5.
Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. PMID: 27548576; PMCID: PMC5215920.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 2016 11 03; 19(5):663-671.
Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. PMID: 27524440; PMCID: PMC5144538.
View in:
PubMed Mentions:
280 Fields:
Translation:
HumansAnimalsCells
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Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci. 2016 05 26; 19(6):771-83.
Sweeney MD, Ayyadurai S, Zlokovic BV. PMID: 27227366; PMCID: PMC5745011.
View in:
PubMed Mentions:
483 Fields:
Translation:
HumansAnimalsCells
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Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4.
Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. PMID: 27207428; PMCID: PMC4904825.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
-
Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707.
Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. PMID: 27038189; PMCID: PMC5283382.
View in:
PubMed Mentions:
98 Fields:
Translation:
HumansAnimals
-
Clearance systems in the brain--implications for Alzheimer diseaser. Nat Rev Neurol. 2016 Apr; 12(4):248.
Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. PMID: 27020556.
View in:
PubMed Mentions:
29 Fields:
-
Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46.
Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. PMID: 26941593; PMCID: PMC4761864.
View in:
PubMed Mentions:
2
-
Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25.
Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. PMID: 26198175; PMCID: PMC4758552.
View in:
PubMed Mentions:
105 Fields:
Translation:
Humans
-
Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27.
Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. PMID: 25757756; PMCID: PMC4758554.
View in:
PubMed Mentions:
322 Fields:
Translation:
HumansCells
-
Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4.
Montagne A, Toga AW, Zlokovic BV. PMID: 26524294; PMCID: PMC4736734.
View in:
PubMed Mentions:
49 Fields:
Translation:
HumansAnimals
-
Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900.
Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. PMID: 26705676; PMCID: PMC4821735.
View in:
PubMed Mentions:
246 Fields:
Translation:
HumansAnimals
-
Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 2015 Nov 19; 163(5):1064-1078.
Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. PMID: 26590417; PMCID: PMC4655822.
View in:
PubMed Mentions:
723 Fields:
Translation:
HumansAnimalsCells
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Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101.
Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. PMID: 26407747; PMCID: PMC4631673.
View in:
PubMed Mentions:
77 Fields:
Translation:
HumansCells
-
Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344.
Amar AP, Griffin JH, Zlokovic BV. PMID: 26388732; PMCID: PMC4556986.
View in:
PubMed Mentions:
15
-
Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015 Aug; 11(8):457-70.
Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. PMID: 26195256; PMCID: PMC4694579.
View in:
PubMed Mentions:
699 Fields:
Translation:
HumansCells
-
Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136.
Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. PMID: 26236233; PMCID: PMC4502358.
View in:
PubMed Mentions:
96
-
Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77.
Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. PMID: 26077645; PMCID: PMC4726482.
View in:
PubMed Mentions:
62 Fields:
Translation:
Humans
-
ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19.
Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. PMID: 26076957; PMCID: PMC4466867.
View in:
PubMed Mentions:
49 Fields:
Translation:
Humans
-
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850; PMCID: PMC4482781.
View in:
PubMed Mentions:
225 Fields:
Translation:
HumansAnimalsCells
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Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol. 2015 May; 72(5):495-6.
Montagne A, Pa J, Zlokovic BV. PMID: 25751405; PMCID: PMC4428924.
View in:
PubMed Mentions:
21 Fields:
Translation:
Humans
-
Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68.
Sweeney MD, Sagare AP, Zlokovic BV. PMID: 25899298; PMCID: PMC4640280.
View in:
PubMed Mentions:
54 Fields:
Translation:
HumansAnimalsCells
-
Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907.
Griffin JH, Zlokovic BV, Mosnier LO. PMID: 25824691; PMCID: PMC4424414.
View in:
PubMed Mentions:
138 Fields:
Translation:
HumansAnimals
-
7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413.
Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. PMID: 25859293; PMCID: PMC4386863.
View in:
PubMed Mentions:
9
-
GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530.
Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. PMID: 25730668; PMCID: PMC4734893.
View in:
PubMed Mentions:
307 Fields:
Translation:
Animals
-
Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302.
Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. PMID: 25611508; PMCID: PMC4350773.
View in:
PubMed Mentions:
963 Fields:
Translation:
HumansCells
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Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 2015 Jun; 11(6):710-7.
Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC. PMID: 25510382; PMCID: PMC4731036.
View in:
PubMed Mentions:
299 Fields:
Translation:
HumansAnimals
-
Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92.
Mosnier LO, Zlokovic BV, Griffin JH. PMID: 25230930; PMCID: PMC4356129.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014 Sep 05; 5:4820.
Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. PMID: 25190485; PMCID: PMC4157316.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 2014 Aug 26; 83(9):851-60.
Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, Sieber BA, Silverberg NB, Sutherland M, Torborg CL, Waddy SP, Zlokovic BV, Corriveau RA, ADRD 2013 Conference Organizing Committee. PMID: 25080517; PMCID: PMC4155046.
View in:
PubMed Mentions:
67 Fields:
Translation:
Humans
-
The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86.
Winkler EA, Sagare AP, Zlokovic BV. PMID: 24946075; PMCID: PMC4423607.
View in:
PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30.
Zhao Z, Zlokovic BV. PMID: 24853933; PMCID: PMC4114515.
View in:
PubMed Mentions:
34 Fields:
Translation:
Animals
-
Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42.
Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. PMID: 24591593; PMCID: PMC3964055.
View in:
PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
-
Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. J Thromb Haemost. 2013 Nov; 11(11):2059-62.
Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. PMID: 24034518; PMCID: PMC3850769.
View in:
PubMed Mentions:
5 Fields:
Translation:
Humans
-
Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36.
Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. PMID: 24159062; PMCID: PMC3912991.
View in:
PubMed Mentions:
36 Fields:
Translation:
Animals
-
Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200.
Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. PMID: 24030206; PMCID: PMC4047029.
View in:
PubMed Mentions:
74 Fields:
Translation:
Humans
-
A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66.
Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. PMID: 23580652; PMCID: PMC3663536.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90.
Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. PMID: 23554499; PMCID: PMC3707621.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol. 2013 Apr; 70(4):440-4.
Zlokovic BV. PMID: 23400708; PMCID: PMC4414030.
View in:
PubMed Mentions:
140 Fields:
Translation:
HumansAnimals
-
Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8.
Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. PMID: 23541526; PMCID: PMC3812054.
View in:
PubMed Mentions:
9 Fields:
Translation:
Animals
-
A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4.
Zlokovic BV. PMID: 23441580.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104.
Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. PMID: 23438513; PMCID: PMC3739836.
View in:
PubMed Mentions:
18 Fields:
Translation:
Animals
-
Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013; 4:2932.
Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 24336108; PMCID: PMC3945879.
View in:
PubMed Mentions:
345 Fields:
Translation:
AnimalsCells
-
Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S87-100.
Sagare AP, Bell RD, Zlokovic BV. PMID: 22751174; PMCID: PMC4416477.
View in:
PubMed Mentions:
76 Fields:
Translation:
HumansAnimals
-
Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85.
Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. PMID: 24372304; PMCID: PMC4040367.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansCTClinical Trials
-
Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol. 2013 May; 23(3):303-10.
Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. PMID: 23126372; PMCID: PMC3628957.
View in:
PubMed Mentions:
281 Fields:
Translation:
HumansCells
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Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10).
Sagare AP, Bell RD, Zlokovic BV. PMID: 23028132; PMCID: PMC3475405.
View in:
PubMed Mentions:
125 Fields:
Translation:
HumansAnimals
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Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol. 2013 Jan; 125(1):111-20.
Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. PMID: 22941226; PMCID: PMC3535352.
View in:
PubMed Mentions:
182 Fields:
Translation:
HumansCells
-
Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7.
Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. PMID: 22927427; PMCID: PMC3458349.
View in:
PubMed Mentions:
88 Fields:
Translation:
Animals
-
Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52.
Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. PMID: 22850407; PMCID: PMC3463878.
View in:
PubMed Mentions:
117 Fields:
Translation:
AnimalsCells
-
Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 2012 Oct; 136(1):94-105.
Sagare AP, Deane R, Zlokovic BV. PMID: 22820095; PMCID: PMC3432694.
View in:
PubMed Mentions:
56 Fields:
Translation:
HumansAnimals
-
An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9.
Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. PMID: 22811462; PMCID: PMC3429704.
View in:
PubMed Mentions:
42 Fields:
Translation:
Animals
-
Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension. 2012 Jul; 60(1):188-97.
Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G. PMID: 22615109; PMCID: PMC3530195.
View in:
PubMed Mentions:
114 Fields:
Translation:
Animals
-
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 16; 485(7399):512-6.
Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 22622580; PMCID: PMC4047116.
View in:
PubMed Mentions:
676 Fields:
Translation:
HumansAnimalsCells
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Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45.
Griffin JH, Zlokovic BV, Mosnier LO. PMID: 22477541; PMCID: PMC3413316.
View in:
PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92.
Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. PMID: 22406537; PMCID: PMC3314449.
View in:
PubMed Mentions:
288 Fields:
Translation:
HumansAnimalsCells
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Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22.
Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. PMID: 22632606; PMCID: PMC3472038.
View in:
PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
-
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38.
Zlokovic BV. PMID: 22048062; PMCID: PMC4036520.
View in:
PubMed Mentions:
1331 Fields:
Translation:
HumansAnimalsCells
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Central nervous system pericytes in health and disease. Nat Neurosci. 2011 Oct 26; 14(11):1398-1405.
Winkler EA, Bell RD, Zlokovic BV. PMID: 22030551; PMCID: PMC4020628.
View in:
PubMed Mentions:
498 Fields:
Translation:
HumansCells
-
From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res. 2011 Jul; 89(7):967-8.
Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. PMID: 21544850.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimals
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Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4.
Zhong Z, Winkler EA, Zlokovic BV. PMID: 21413850.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
-
Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell. 2011 Mar 15; 20(3):279-80.
Winkler EA, Bell RD, Zlokovic BV. PMID: 21397835.
View in:
PubMed Mentions:
14 Fields:
-
Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209.
Zlokovic BV, Griffin JH. PMID: 21353711; PMCID: PMC3491752.
View in:
PubMed Mentions:
85 Fields:
Translation:
HumansAnimalsCells
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Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13.
Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21291561; PMCID: PMC3042387.
View in:
PubMed Mentions:
15 Fields:
-
Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis. 2011; 24(1):25-34.
Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. PMID: 21157031; PMCID: PMC4096563.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Methamphetamine causes sustained depression in cerebral blood flow. Brain Res. 2011 Feb 10; 1373:91-100.
Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. PMID: 21156163; PMCID: PMC3026925.
View in:
PubMed Mentions:
34 Fields:
Translation:
Animals
-
Neurodegeneration and the neurovascular unit. Nat Med. 2010 Dec; 16(12):1370-1.
Zlokovic BV. PMID: 21135839.
View in:
PubMed Mentions:
93 Fields:
Translation:
HumansAnimalsCells
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Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34.
Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21084607; PMCID: PMC3012432.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27.
Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 21040844; PMCID: PMC3056408.
View in:
PubMed Mentions:
795 Fields:
Translation:
AnimalsCells
-
Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89.
Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. PMID: 20854368; PMCID: PMC2972355.
View in:
PubMed Mentions:
135 Fields:
Translation:
HumansAnimals
-
Pericyte constriction after stroke: the jury is still out. Nat Med. 2010 Sep; 16(9):959; author reply 960.
Vates GE, Takano T, Zlokovic B, Nedergaard M. PMID: 20823870.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
-
Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener. 2010 Aug 25; 5:32.
Winkler EA, Bell RD, Zlokovic BV. PMID: 20738866; PMCID: PMC2936891.
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PubMed Mentions:
167 Fields:
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Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Res. 2010 Aug 06; 1347:125-31.
Walker CT, Marky AH, Petraglia AL, Ali T, Chow N, Zlokovic BV. PMID: 20513369; PMCID: PMC4068704.
View in:
PubMed Mentions:
25 Fields:
Translation:
AnimalsCells
-
Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72.
Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. PMID: 20348395; PMCID: PMC2890172.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansAnimalsCells
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Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26.
Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. PMID: 20043896; PMCID: PMC2861918.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2.
Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. PMID: 20023547; PMCID: PMC2800370.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. PMID: 19841542; PMCID: PMC2769191.
View in:
PubMed Mentions:
105 Fields:
Translation:
AnimalsCells
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Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31.
Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. PMID: 19815836; PMCID: PMC2791928.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009 Jul; 118(1):103-13.
Bell RD, Zlokovic BV. PMID: 19319544; PMCID: PMC2853006.
View in:
PubMed Mentions:
393 Fields:
Translation:
HumansAnimalsCells
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Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30.
Deane R, Bell RD, Sagare A, Zlokovic BV. PMID: 19275634; PMCID: PMC2872930.
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PubMed Mentions:
255 Fields:
Translation:
HumansAnimals
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Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30.
Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. PMID: 19302148; PMCID: PMC2692517.
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PubMed Mentions:
50 Translation:
HumansAnimalsCells
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Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24.
Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. PMID: 19166505; PMCID: PMC2692505.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53.
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 19098903; PMCID: PMC2654279.
View in:
PubMed Mentions:
134 Fields:
Translation:
HumansAnimalsCells
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Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009 May; 40(5):1864-9.
Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. PMID: 19057019; PMCID: PMC2691176.
View in:
PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97.
Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. PMID: 19036971; PMCID: PMC2742231.
View in:
PubMed Mentions:
68 Fields:
Translation:
AnimalsCells
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apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13.
Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. PMID: 19033669; PMCID: PMC2582453.
View in:
PubMed Mentions:
380 Fields:
Translation:
HumansAnimalsCells
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Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33.
Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. PMID: 18841163; PMCID: PMC2895315.
View in:
PubMed Mentions:
42 Fields:
Translation:
AnimalsCells
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New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):409-14.
Zlokovic BV. PMID: 18625452; PMCID: PMC2536515.
View in:
PubMed Mentions:
65 Fields:
Translation:
HumansAnimals
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Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10.
Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. PMID: 18451334; PMCID: PMC2574857.
View in:
PubMed Mentions:
66 Fields:
Translation:
HumansAnimalsCells
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ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2.
Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. PMID: 18344992; PMCID: PMC2895310.
View in:
PubMed Mentions:
224 Fields:
Translation:
HumansAnimalsCells
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The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24; 57(2):178-201.
Zlokovic BV. PMID: 18215617.
View in:
PubMed Mentions:
1446 Fields:
Translation:
HumansAnimals
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The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5.
Deane R, Sagare A, Zlokovic BV. PMID: 18673201; PMCID: PMC2895311.
View in:
PubMed Mentions:
101 Fields:
Translation:
HumansAnimals
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Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71.
Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. PMID: 17971789; PMCID: PMC2744583.
View in:
PubMed Mentions:
128 Fields:
Translation:
AnimalsCells
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Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31.
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. PMID: 17694066; PMCID: PMC2936449.
View in:
PubMed Mentions:
199 Fields:
Translation:
HumansAnimals
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Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):191-7.
Deane R, Zlokovic BV. PMID: 17430246.
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PubMed Mentions:
154 Fields:
Translation:
HumansAnimals
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Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7.
Thiyagarajan M, Cheng T, Zlokovic BV. PMID: 17272817.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:40-50.
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. PMID: 17413008.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8.
Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 17215356; PMCID: PMC1783398.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansAnimalsCells
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The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72.
Mosnier LO, Zlokovic BV, Griffin JH. PMID: 17110453.
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PubMed Mentions:
347 Fields:
Translation:
HumansAnimals
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Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18.
Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. PMID: 17077814; PMCID: PMC2853021.
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PubMed Mentions:
304 Fields:
Translation:
HumansAnimals
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Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85.
Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 17072311.
View in:
PubMed Mentions:
125 Fields:
Translation:
AnimalsCells
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Remodeling after stroke. Nat Med. 2006 Apr; 12(4):390-1.
Zlokovic BV. PMID: 16598283.
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PubMed Mentions:
27 Fields:
Translation:
HumansAnimalsCells
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The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6.
Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 16464623.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimals
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IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503.
Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. PMID: 16354907; PMCID: PMC6726020.
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PubMed Mentions:
112 Fields:
Translation:
HumansAnimals
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P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90.
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. PMID: 16239972; PMCID: PMC1257538.
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PubMed Mentions:
290 Fields:
Translation:
AnimalsCells
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Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7.
Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. PMID: 16130108.
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PubMed Mentions:
38 Fields:
Translation:
AnimalsCells
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Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65.
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. PMID: 16116430.
View in:
PubMed Mentions:
128 Fields:
Translation:
HumansAnimalsCells
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Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr; 28(4):202-8.
Zlokovic BV. PMID: 15808355.
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PubMed Mentions:
378 Fields:
Translation:
HumansAnimals
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Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76.
Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. PMID: 15743889.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathol. 2005 Jan; 15(1):78-83.
Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. PMID: 15779240; PMCID: PMC8095816.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimals
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Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83.
Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. PMID: 15516929.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
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RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov; 35(11 Suppl 1):2628-31.
Deane R, Wu Z, Zlokovic BV. PMID: 15459432.
View in:
PubMed Mentions:
168 Fields:
Translation:
HumansAnimals
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Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42.
LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. PMID: 15325132.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimals
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LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44.
Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. PMID: 15294142.
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PubMed Mentions:
414 Fields:
Translation:
HumansAnimalsCells
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Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16.
Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. PMID: 15183014.
View in:
PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53.
Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 15118526.
View in:
PubMed Mentions:
21 Fields:
Translation:
HumansAnimals
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Clearing amyloid through the blood-brain barrier. J Neurochem. 2004 May; 89(4):807-11.
Zlokovic BV. PMID: 15140180.
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PubMed Mentions:
120 Fields:
Translation:
HumansAnimals
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Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 07; 279(19):20296-306.
Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. PMID: 14985348.
View in:
PubMed Mentions:
200 Fields:
Translation:
HumansAnimalsCells
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Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72.
Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. PMID: 14980205.
View in:
PubMed Mentions:
115 Fields:
Translation:
AnimalsCells
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Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004 Feb; 88(4):813-20.
Deane R, Zheng W, Zlokovic BV. PMID: 14756801; PMCID: PMC3980859.
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PubMed Mentions:
43 Fields:
Translation:
AnimalsCells
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A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63.
Wu Z, Hofman FM, Zlokovic BV. PMID: 14583404.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13.
Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. PMID: 12808450.
View in:
PubMed Mentions:
632 Fields:
Translation:
HumansAnimals
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Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6.
Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. PMID: 12737945.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimals
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Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6.
Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. PMID: 12665496.
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PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801.
Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. PMID: 12586611.
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PubMed Mentions:
47 Fields:
Translation:
HumansCells
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Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42.
Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. PMID: 12563316.
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PubMed Mentions:
207 Fields:
Translation:
HumansAnimalsCells
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Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3.
Amar AP, Zlokovic BV, Apuzzo ML. PMID: 12535371.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Current treatments and therapeutic targets in Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7.
Zlokovic BV. PMID: 12453670.
View in:
PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1553-9.
Zlokovic BV. PMID: 12453672.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimals
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Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904.
Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. PMID: 12176746.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205.
Griffin JH, Zlokovic B, Fernández JA. PMID: 12124682.
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PubMed Mentions:
35 Fields:
Translation:
Humans
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Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun; 38(6):303-13.
Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. PMID: 12529925.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimals
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Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target. 2002 Jun; 10(4):359-68.
Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. PMID: 12164385.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2002 Jun; 4(3):217-23.
Grammas P, Yamada M, Zlokovic B. PMID: 12226540.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun; 23(3):405-12.
Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. PMID: 11959403.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2001 May; 48(5):1196-7.
Zlokovic BV, Cox C. PMID: 11334298.
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PubMed Mentions: Fields:
Translation:
Humans
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Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73.
Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. PMID: 11311331.
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PubMed Mentions:
22 Fields:
Translation:
HumansAnimalsCells
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Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805.
Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. PMID: 11282913.
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PubMed Mentions:
73 Fields:
Translation:
HumansAnimalsCells
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Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001 Jan; 48(1):151-7.
MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. PMID: 11152340.
View in:
PubMed Mentions:
76 Fields:
Translation:
HumansAnimals
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Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec; 106(12):1489-99.
Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. PMID: 11120756; PMCID: PMC387254.
View in:
PubMed Mentions:
584 Fields:
Translation:
HumansAnimalsCells
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beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81.
Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. PMID: 11078691.
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PubMed Mentions:
83 Fields:
Translation:
HumansCells
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Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech. 2000 Aug 15; 50(4):305-15.
Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. PMID: 10936885.
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PubMed Mentions:
88 Fields:
Translation:
Humans
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Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57.
Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. PMID: 10899440.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9.
Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. PMID: 10888892.
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PubMed Mentions:
27 Fields:
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Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 01; 348 Pt 2:359-65.
Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. PMID: 10816430; PMCID: PMC1221074.
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PubMed Mentions:
113 Fields:
Translation:
HumansAnimalsCells
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Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009.
Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. PMID: 10894183.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000 Apr; 141(4):1434-41.
Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. PMID: 10746647.
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PubMed Mentions:
55 Fields:
Translation:
AnimalsCells
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Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999 Dec 01; 344 Pt 2:375-83.
Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. PMID: 10567218; PMCID: PMC1220653.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6.
Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. PMID: 10559029.
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PubMed Mentions:
34 Fields:
Translation:
Animals
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Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70.
Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. PMID: 10515502.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett. 1999 Sep 10; 272(2):127-30.
Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. PMID: 10507558.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res. 1999 Sep; 16(9):1360-5.
Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. PMID: 10496650.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea. 1999 May; 18(3):321-7.
Kannan R, Mackic JB, Zlokovic BV. PMID: 10336036.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol. 1999 May; 157(1):194-201.
Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. PMID: 10222122.
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PubMed Mentions:
25 Fields:
Translation:
Animals
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Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec 01; 92(5):213-9.
Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. PMID: 9851812.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3.
MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. PMID: 9848858.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery. 1998 Oct; 43(4):909-13.
Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. PMID: 9766319.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998 Oct; 43(4):877-8.
Zlokovic BV, Apuzzo ML. PMID: 9766315.
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PubMed Mentions:
14 Fields:
Translation:
Humans
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Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug 15; 91(4):191-7.
Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. PMID: 9736422.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43.
Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. PMID: 9710442; PMCID: PMC508936.
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PubMed Mentions:
84 Fields:
Translation:
HumansCells
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Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther. 1998 May 01; 9(7):989-95.
LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. PMID: 9607410.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan; 70(1):210-5.
Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. PMID: 9422364.
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PubMed Mentions:
41 Fields:
Translation:
AnimalsCells
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Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8.
Lavine SD, Hofman FM, Zlokovic BV. PMID: 9428305.
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PubMed Mentions:
49 Fields:
Translation:
Animals
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Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. J Neurosurg. 1997 Nov; 87(5):731-7.
Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. PMID: 9347982.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46.
Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. PMID: 9409303.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem. 1997 Nov; 69(5):1995-2004.
Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. PMID: 9349544.
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PubMed Mentions:
52 Fields:
Translation:
HumansAnimalsCells
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Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 1997 Jun 15; 2(6):e5.
Zlokovic BV. PMID: 15099052.
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PubMed Mentions:
5 Fields:
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Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26.
Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 9227280.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs. Curr Eye Res. 1997 Apr; 16(4):365-71.
Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. PMID: 9134326.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4.
Zlokovic BV, Apuzzo ML. PMID: 9092853.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimals
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Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3.
Zlokovic BV, Apuzzo ML. PMID: 9092854.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46.
Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. PMID: 9040492.
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PubMed Mentions:
36 Fields:
Translation:
Animals
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Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharm Res. 1997 Jan; 14(1):80-5.
Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. PMID: 9034225.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiol Dis. 1997; 4(1):23-6.
Zlokovic B. PMID: 9258908.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75.
Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. PMID: 8843923.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34.
Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. PMID: 8633046; PMCID: PMC39517.
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PubMed Mentions:
140 Fields:
Translation:
AnimalsCells
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Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8.
Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. PMID: 8621654.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke. 1996 Apr; 27(4):712-9.
Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. PMID: 8614937.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci Lett. 1996 Mar 15; 206(2-3):157-60.
Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. PMID: 8710175.
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PubMed Mentions:
26 Fields:
Translation:
AnimalsCells
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Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5.
Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. PMID: 8932451.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Cellular uptake and transport of methylprednisolone at the blood-brain barrier. Neurosurgery. 1996 Feb; 38(2):348-54.
Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. PMID: 8869063.
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PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
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Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37.
Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 8674510.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci. 1996; 59(18):1483-97.
Zlokovic BV. PMID: 8890929.
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PubMed Mentions:
52 Fields:
Translation:
Humans
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Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 1995 Nov; 37(5):955-61.
Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. PMID: 8559345.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7.
Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. PMID: 7591644.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res. 1995 Oct; 12(10):1395-406.
Zlokovic BV. PMID: 8584471.
View in:
PubMed Mentions:
51 Fields:
Translation:
Animals
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Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92.
Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. PMID: 7635653.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14.
Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. PMID: 8642902.
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PubMed Mentions: Fields:
Translation:
Animals
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Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism. Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5.
Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic LM. PMID: 7549442.
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PubMed Mentions: Fields:
Translation:
Animals
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Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7.
Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. PMID: 7802679.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96.
Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. PMID: 7859824.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8.
Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. PMID: 8198602.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
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Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7.
Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. PMID: 8147886.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10.
Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. PMID: 8125742.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40.
Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. PMID: 8280117.
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PubMed Mentions:
61 Fields:
Translation:
HumansAnimals
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The blood-brain barrier in vitro: recent progress. Neurochem Int. 1993 Dec; 23(6):523.
Zlokovic BV. PMID: 8281120.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25.
Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. PMID: 8385133.
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PubMed Mentions:
35 Fields:
Translation:
Animals
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Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9.
Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. PMID: 8384107.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10.
Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. PMID: 8384106.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
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Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60.
Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. PMID: 8392783.
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PubMed Mentions: Fields:
Translation:
Animals
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A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Exp Eye Res. 1993 Jan; 56(1):45-50.
Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. PMID: 8432334.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Blood-brain transport of vasopressin. Adv Exp Med Biol. 1993; 331:143-7.
Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. PMID: 8333329.
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PubMed Mentions: Fields:
Translation:
Animals
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Differential brain penetration of cerebroprotective drugs. Adv Exp Med Biol. 1993; 331:117-20.
Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. PMID: 8333325.
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PubMed Mentions: Fields:
Translation:
Animals
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Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res. 1992 Sep 11; 590(1-2):213-8.
Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. PMID: 1422832.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Exp Eye Res. 1992 Mar; 54(3):471-7.
Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. PMID: 1381681.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse. NIDA Res Monogr. 1992; 120:26-42.
Zlokovic BV, McComb JG, Perlmutter L, Weiss MH, Davson H. PMID: 1501689.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 1991 Nov-Dec; 32(6):783-90.
Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. PMID: 1743149.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40.
Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. PMID: 1902062.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24.
Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. PMID: 1899978.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta. Agents Actions Suppl. 1991; 33:283-7.
Rosic M, Collis CS, Anjelkovic IZ, Segal MB, Djuric D, Zlokovic BV. PMID: 1647128.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem. 1990 Oct; 55(4):1222-30.
Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, Greenwood J. PMID: 2398356.
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PubMed Mentions:
28 Fields:
Translation:
Animals
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Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8.
Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. PMID: 2364078.
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PubMed Mentions:
28 Fields:
Translation:
Animals
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Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94.
Segal MB, Preston JE, Collis CS, Zlokovic BV. PMID: 2186633.
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PubMed Mentions:
18 Fields:
Translation:
Animals
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Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep. Endocrinol Exp. 1990 Mar; 24(1-2):29-36.
Segal MB, Preston JE, Zlokovic B. PMID: 2361466.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990 Mar; 107(3):263-70.
Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. PMID: 1689666.
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PubMed Mentions:
25 Fields:
Translation:
Animals
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Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers. Endocrinol Exp. 1990 Mar; 24(1-2):9-17.
Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG. PMID: 2193795.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Immunoneurology: a serum protein afferent limb to the CNS. Adv Exp Med Biol. 1990; 274:345-70.
Kozlowski GP, Nilaver G, Zlokovic BV. PMID: 2239432.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. J Neurol Sci. 1989 Dec; 94(1-3):41-50.
Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. PMID: 2515257.
View in:
PubMed Mentions:
2 Fields:
Translation:
Animals
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Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem. 1989 Nov; 53(5):1333-40.
Zlokovic BV, Mackic JB, Djuricic B, Davson H. PMID: 2795003.
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PubMed Mentions:
21 Fields:
Translation:
AnimalsCells
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Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur J Pharmacol. 1989 Jun 08; 165(1):155-9.
Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. PMID: 2548879.
View in:
PubMed Mentions:
1 Fields:
Translation:
Animals
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Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis. 1989 Mar; 4(1):33-40.
Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H, et al. PMID: 2495422.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
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Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metab Brain Dis. 1989 Mar; 4(1):9-15.
Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. PMID: 2495423.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
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Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989 Mar-Apr; 10(2):249-54.
Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. PMID: 2547200.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Neutral amino acid uptake by the isolated perfused sheep choroid plexus. J Physiol. 1989 Jan; 408:31-43.
Preston JE, Segal MB, Walley GJ, Zlokovic BV. PMID: 2506339; PMCID: PMC1190388.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem. 1988 Jul; 51(1):252-7.
Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3132534.
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PubMed Mentions:
11 Fields:
Translation:
Animals
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Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1988 May-Jun; 9(3):533-8.
Zlokovic BV, Segal MB, Davson H, Jankov RM. PMID: 3420012.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16.
Zlokovic BV, Andjelkovic IZ. PMID: 2460051.
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Animals
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Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept. 1988 Jan; 20(1):33-44.
Zlokovic BV, Segal MB, Davson H, Mitrovic DM. PMID: 3127863.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Exp Neurol. 1987 Nov; 98(2):436-52.
Zlokovic BV, Davson H, Preston JE, Segal MB. PMID: 2444450.
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Animals
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Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem. 1987 Jul; 49(1):310-5.
Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3585338.
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PubMed Mentions:
38 Fields:
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Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J Neurochem. 1986 May; 46(5):1444-51.
Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM. PMID: 3083044.
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PubMed Mentions:
21 Fields:
Translation:
Animals
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Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 1985 Dec 09; 358(1-2):191-9.
Zlokovic BV, Segal MB, Begley DJ, Davson H, Rakic L. PMID: 3935272.
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PubMed Mentions:
32 Fields:
Translation:
Animals
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Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8.
Mann GE, Zlokovic BV, Yudilevich DL. PMID: 4041458.
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PubMed Mentions:
37 Fields:
Translation:
AnimalsCells
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Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985 Jun 10; 336(1):125-32.
Zlokovic BV, Begley DJ, Chain-Eliash DG. PMID: 3891014.
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PubMed Mentions:
44 Fields:
Translation:
Animals
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Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res. 1983 Jul 18; 271(1):65-71.
Zlokovic BV, Begley DJ, Chain DG. PMID: 6883121.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol. 1982 Jul; 76(3):483-9.
Andjelkovic I, Zlokovic B. PMID: 6179557; PMCID: PMC2071802.
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PubMed Mentions:
3 Fields:
Translation:
Animals