Berislav V Zlokovic, MD, PhD

Title(s)Chair and University Professor of Physiology & Neuroscience
AddressZNI 101 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2722
vCardDownload vCard
    Other Positions
    Title(s)Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research

    Title(s)Director, Zilkha Neurogenetic Institute


    Collapse Overview 
    Collapse Overview
    Berislav V. Zlokovic is the director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC, and a Professor of Biological Sciences at the Dornsife College of Letters, Arts and Sciences. Zlokovic studies the role of brain microcirculation, particularly the blood-brain barrier (BBB) in health and disease in the adult brain and during brain aging. He made major contributions to our understanding of the role of BBB in the pathogenesis and treatment of Alzheimer’s disease (AD) and stroke. Using animal models and studying human brain, his laboratory has shown that dysfunction in the BBB and brain microcirculation can accumulate before neuronal loss, and is an early biomarker of human cognitive dysfunction. His group showed that disrupted cross-talk between BBB-associated pericytes and brain capillary endothelial cells, and astrocytes and pericytes, within the neurovascular unit leads to neuronal dysfunction in both synapses and neurons, and that targeting the BBB cellular and molecular pathways can slow down, arrest and of prevent development of a neurodegenerative process. He has identified genes and receptors at the BBB that regulate brain levels of Alzheimer’s amyloid-beta toxin, which accumulates with aging and dementia. More recently, his team has developed new imaging techniques for studying BBB function in animal models and the living human brain. These findings contributed to development of Phase 2/3 clinical trials for AD patients. He co-discovered with J.H. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C (APC) in the CNS, including the receptor requirements and downstream signaling pathways. These findings have been translated in successfully completed Phase 2 trial of 3K3A-APC, a 2nd generation cytoprotective-selective APC analog, in ischemic stroke patients, which led to a Phase 3 efficacy and safety pivotal trial of 3K3A-APC in patients with ischemic stroke.

    Current research interests
    • We study humans at genetic risk for AD, and use transgenic models, and iPSC-based human models of the BBB and brain on a chip to understand how genes that carry risk for sporadic AD (e.g., APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD disease onset and progression.
    • We are developing cell and gene therapy approaches for AD using i) iPSC-derived human pericytes that express different protective target genes, and/or ii) BBB cell-specific gene delivery to influence neuronal and synaptic functions.
    • We study APC biologics and mimetic peptides for white matter stroke, AD and ALS.
    • We work on identifying small molecules that influence genes/pathways linked to AD.
    • We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
    • Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic and human iPSC models.
    • We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human brain tissue.

    Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 18 consecutive years (2002-2020) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, Potamkin Prize from the American Academy of Neurology in recognition of outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, Javits Award from NINDS in recognition of distinguished record of substantial contributions in a field of neurological sciences”, MERIT Award from NIA in recognition of sustained contribution to aging and leadership and commitment to the field”, and more recently USC Associates Award for Creativity in Research and Scholarship “the highest honor the university faculty bestows on its members for distinguished intellectual achievements” He is a fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. In 2017, 2018, 2019, 2020 and 2021, he was asked by the Nobel Assembly at Karolinska Institutet, The Nobel Committee to nominate candidates for the Nobel Prize in Physiology and Medicine. He is an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders.

    Featured Publications representing interests of the Zlokovic laboratory:

    i-10 index: 259; h-index: 107; 51,753 citations (Google Scholar, Mar 2021); complete list in Google Scholar: https://goo.gl/2Npcj2

    Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. (2021) Endothelial LRP1 protects against neurodegeneration via cyclophilin A. Journal of Experimental Medicine 218(4):e20202207

    Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D’Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Julia TCW, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. (2020) APOE4 leads to early blood-brain barrier dysfunction predicting human cognitive decline. Nature 581, 71-76.

    Zhao Z, Zlokovic BV. (2020) Therapeutic TVs for crossing barriers in the brain. Cell 182(2):267-269.

    Nation DA, Sweeney MD, Montagne A, Sagare AP, D’Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel D, Liu CY, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV (2019) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine 25, 270-276.

    Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience 22, 1089–1098.

    Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews 99, 21-78.

    Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV (2019) 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. Journal of Experimental Medicine 216(2), 279-293.

    Lyden P, Pryor KE, Coffey CS, Cudkowicz M, …Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators. (2019) Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Annals of Neurology 85(1), 125-136.

    Sweeney MD, Kisler K, Montagne A, Toga A, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience 21(10), 1318-1331

    Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV (2018) Pericyte degeneration causes white matter dysfunction in the mouse CNS. Nature Medicine 24(3), 326-337.

    Sweeney MD, Sagare AP, Zlokovic BV (2018) Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders. Nature Reviews Neurology 14(3), 133-150.

    Kisler K, Lazic D, Sweeney M, Plunkett S, Khatib ME, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV (2018) Diverse protocols for in vivo measurements of cerebrovascular hemodynamic responses and tissue oxygen levels and delivery in the mouse brain. Nature Protocols 13(6), 1377-1402.

    Sweeney MD, Zlokovic BV (2018) A lymphatic waste-disposal system implicated in Alzheimer’s disease. Nature 560 (7717) 172-174.

    Kisler K, Nelson A, Montagne A, Zlokovic BV (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer’s disease. Nature Reviews Neuroscience 18, 419-434.

    Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV (2017) Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience 20, 406-416.

    Wang Y, Zhao Z, Rege S, Griffin JH, Goldman SA, Zlokovic BV (2016) 3K3A-APC stimulates post-ischemic neuronal repair by human neural progenitor cells in mice. Nature Medicine 22 (9): 1050-1055.

    Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience 19 (6): 771-783.

    Zhao Z, Nelson A, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of blood-brain barrier. Cell 163, Nov 19;163(5):1064-78.

    Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NQ, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance. Nature Neuroscience 18, 978-987.

    Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience 18, 521-530.

    Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.

    Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated Protein C: Biased for Translation. Blood 125 (19), 2898-2907.

    Zhao Z and Zlokovic BV (2014) Blood-Brain Barrier: A Dual Life of MFSD2A? Neuron 82, 728–730.

    Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong G, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV (2014) Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proceedings of the National Academy of Sciences USA 111(11), E1035-42.

    Bell RD, Winkler E, Sagare A, Singh I, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk B, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.

    Deane R, Singh I, Sagare A, Bell R, Ross NT, Larue B, Love R, Perry S, Deane RJ, Thiyagarajan M, Zarcone T, Friedman A, Miller BL, Zlokovic BV (2012) A novel multi-modal RAGE-specific inhibitor controls amyloid-beta-mediated brain disorder in mice. Journal of Clinical Investigation 122 (4), 1377-1392.

    Winkler E, Bell R, Zlokovic BV (2011) Functions of CNS pericytes in health and disease. Nature Neuroscience 14, 1398-1405.

    Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nature Reviews Neuroscience 12, 723-738.

    Winkler EA, Bell RD, Zlokovic BV (2011) Lack of Smad and Notch Leads to a Fatal Game of Brain Pericyte Hopscotch. Developmental Cell (Cell) 20 (3), 279-281.

    Zlokovic BV, Griffin JH (2011) Activated protein C cytoprotective pathways and implications for stroke and neurological disorders. Trends in Neurosciences 34 (4), 1198-2009.

    Zlokovic BV (2010) Neurodegeneration and the neurovascular unit. Nature Medicine 16(12), 1370-71.

    Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and the neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.

    Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV (2010) Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115, 4963-4972.

    Bell RD , Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JP, Zlokovic BV (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology 11(2), 143-153.

    Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino F, Stojanovic K, Cleveland DW, Zlokovic BV (2009) Activated protein C slows ALS-like disease by transcrptionally inhibiting SOD1 in motor neurons and microglial cells. Journal of Clinical Investigation 119(11), 3437-3440.

    Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) Apolipoprotein E isoform-specific disruption of Alzheimer’s amyloid ?-peptide clearance from mouse brain. Journal of Clinical Investigation 118(12), 4002-4013.

    Zhong Z, Deane R, Zarina A, Parisi M, Shapovalov Y, 0’Banion K, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience 11(4), 420-422.

    Zlokovic BV (2008) Blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201.

    Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Pelmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine 13 (9), 1029-1031.

    Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV (2007). Serum response factor and myocardin mediate cerebral arterial hypercontractility and blood flow dysregulation in Alzheimer’s phenotype. Proceedings of the National Academy of Sciences USA 104, 823-828.

    Mosnier L, Zlokovic BV, Griffin JH (2007) The cellular protein C pathway. Blood 109(8), 161-172.

    Cheng T, Petraglia A, Li Z, Meedakshisudaram T, Wu Z, Zhong Z, Liu D, Maggirwar SB, Deane R, Fernandez J, LaRue B, Griffin J, Chopp M, Zlokovic BV (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine 12 (11), 1278-1285.

    Zlokovic BV (2006) Remodeling after stroke. Nature Medicine 12 (4) 390-391.

    Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks A, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetski R, Song H, Hofman F, Zlokovic BV (2005) Role of MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine 11(9), 959-965.

    Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer’s neurodegeneration. Trends in Neurosciences 28, 202-208.

    Deane R, Wu Z, Davis J, Yan SD, Hamm K, Sagare A, Xu F, Spijkers P, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-beta interaction mediates differential brain efflux of Abeta isoforms. Neuron 43, 33-44.

    Liu D, Cheng T, Guo H, Fernandez AJ, Griffin JH, Song X, Zlokovic BV (2004) Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine 10, (12), 1379-1383.

    Guo H, Liu D, Gelbard H, Cheng T, Fernandez JA, Insalaca R, Griffin JH, Zlokovic BV (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41, 563-572.

    Deane R, Yan SD, Kumar R, Jovanovic S, LaRue B, Welch D, Maness L, Yu J, Zhu H, Ghiso J, Frangione B, Schmidt AM, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic BV (2003) RAGE mediates amyloid-ß peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9(7), 907-913.

    Cheng T, Liu D, Fernández JA, Griffin JH, Castellino F, Rosen E, Fukudome K, Zlokovic BV (2003) Activated protein C blocks P53-mediated apoptosis in ischemic human brain endothelium and is neuroportective. Nature Medicine 9, 338-342.

    Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003) Activated protein C alters cytosolic Ca2+ flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease-activated receptor-1. Blood 101, 4797-4801.

    Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV (2001) Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis. Circulation 103, 1799-1805.

    Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer’s amyloid-ß1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106(12), 1489-1499.

    Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B (2000) Clearance of amyloid ß-peptide from brain: transport or metabolism? Nature Medicine 6, 718-719.

    Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV (1998) Human blood-brain barrier receptors for Alzheimer's amyloid-? 1-40: Asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. Journal of Clinical Investigation 102, 734-743.

    Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: Porbable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's Disease amyloid-? at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences USA 93, 4229-4236.
    Collapse In The News

    Collapse Research 
    Collapse Research Activities and Funding
    Alzheimer Disease Research Center
    NIH P30AG066530Sep 1, 2020 - Feb 28, 2025
    Role: Co-Principal Investigator
    Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injury
    NIH R01NS117827Jul 15, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Interaction of the microbiome with the blood-brain barrier
    Open Philanthropy Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    The role of PICALM mutations in Alzheimer’s disease
    Cure Alzheimer's Fund Dec 27, 2017 - Dec 28, 2019
    Role: Principal Investigator
    Vascular Contributions To Dementia and Amyloid and Tau Lesions in APOE4
    Alzheimer's Association Sep 30, 2017 - Aug 30, 2022
    Role: Principal Investigator
    Understanding the role of the perivascular space in cerebral small vessel disease
    Fondation Leducq Jan 1, 2017 - Jan 1, 2022
    Role: North American Coordinator
    The role of pericytes in white matter disease
    NIH R01NS100459Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
    NIH P01AG052350Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Activated protein C system in stroke models
    NIH R01NS090904Sep 30, 2014 - Jul 31, 2021
    Role: Principal Investigator
    Caloric restriction and Alzheimers ABeta clearance pathway
    NIH R03AG046216Aug 15, 2013 - May 31, 2017
    Role: Principal Investigator
    The role of PICALM in vascular clearance of amyloid-b
    Cure Alzheimer's Fund Sep 1, 2012 - Nov 30, 2019
    Role: Principal Investigator
    The role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathology
    NIH RF1AG039452Aug 1, 2011 - Jan 31, 2024
    Role: Principal Investigator
    The role of pericytes in the adult and the aging brain
    NIH R01AG039452Aug 1, 2011 - May 31, 2017
    Role: Principal Investigator
    Protein S: Neurovascular Protection in Stroke
    NIH R01HL081528Jul 1, 2006 - Apr 30, 2011
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH R01AG023084Dec 1, 2003 - Mar 31, 2021
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH R37AG023084Dec 1, 2003 - Jun 14, 2015
    Role: Principal Investigator
    Regulation of Brain Thrombosis in Stroke Models
    NIH R01HL063290Jul 15, 1999 - Apr 30, 2015
    Role: Principal Investigator
    AGING BRAIN--CEREBROVASCULAR MECHANISM &AMYLOID BETA
    NIH P01AG016223May 1, 1999 - Apr 30, 2004
    Role: Principal Investigator
    AGING AND BLOOD BRAIN BARRIER AB TRASPORT IN PRIMATES
    NIH R03AG014526Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    Alzheimer's Abeta, Tau, Apolipoproteins and Blood-brain barrier
    NIH R01NS034467Sep 1, 1995 - Feb 28, 2025
    Role: Principal Investigator
    Alzheimer's Abeta, apolipoproteins and blood-brain barrier
    NIH R37NS034467Sep 1, 1995 - Mar 31, 2014
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH R01EY009399Aug 1, 1993 - Jul 31, 1996
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH R55EY009399Sep 30, 1992 - Jul 31, 1993
    Role: Principal Investigator

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microglia have a grip on brain microvasculature. Nat Commun. 2021 09 06; 12(1):5290. Kisler K, Nikolakopoulou AM, Zlokovic BV. PMID: 34489417.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    2. Reply to: Rethink the classical view of cerebrospinal fluid production. Nat Rev Neurol. 2021 Sep; 17(9):590-591. Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Charpak S, Smith KJ, Black SE. PMID: 34253900.
      View in: PubMed   Mentions:    Fields:    
    3. Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model. Environ Health Perspect. 2021 Aug; 129(8):87006. Liu Q, Shkirkova K, Lamorie-Foote K, Connor M, Patel A, Babadjouni R, Huuskonen M, Montagne A, Baertsch H, Zhang H, Chen JC, Mack WJ, Walcott BP, Zlokovic BV, Sioutas C, Morgan TE, Finch CE, Mack WJ. PMID: 34424052.
      View in: PubMed   Mentions:    Fields:    
    4. Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure". J Magn Reson Imaging. 2021 Jul 31. Huuskonen MT, Barisano G, Chakhoyan A, Zlokovic BV. PMID: 34331486.
      View in: PubMed   Mentions:    Fields:    
    5. On the intersection between systemic infection, brain vascular dysfunction and dementia. Brain. 2021 07 28; 144(6):1629-1631. Huuskonen MT, Kisler K, Sagare AP, Zlokovic BV. PMID: 33974045.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021 04 05; 218(4). Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. PMID: 33533918.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    7. Investigating the blood-spinal cord barrier in preclinical models: a systematic review of in vivo imaging techniques. Spinal Cord. 2021 Jun; 59(6):596-612. Bakhsheshian J, Strickland BA, Mack WJ, Zlokovic BV. PMID: 33742118.
      View in: PubMed   Mentions:    Fields:    
    8. Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache. 2021 Mar; 61(3):536-545. Cowan RP, Gross NB, Sweeney MD, Sagare AP, Montagne A, Arakaki X, Fonteh AN, Zlokovic BV, Pogoda JM, Harrington MG. PMID: 33724462.
      View in: PubMed   Mentions:    Fields:    
    9. Stroke Treatment With PAR-1 Agents to Decrease Hemorrhagic Transformation. Front Neurol. 2021; 12:593582. Lyden PD, Pryor KE, Minigh J, Davis TP, Griffin JH, Levy H, Zlokovic BV. PMID: 33790846.
      View in: PubMed   Mentions:
    10. Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Brain Behav Immun. 2021 05; 94:299-307. Albrecht DS, Sagare A, Pachicano M, Sweeney MD, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Morris JC, Benzinger T, Pa J. PMID: 33486003.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    11. Cranial Suture Regeneration Mitigates Skull and Neurocognitive Defects in Craniosynostosis. Cell. 2021 01 07; 184(1):243-256.e18. Yu M, Ma L, Yuan Y, Ye X, Montagne A, He J, Ho TV, Wu Y, Zhao Z, Sta Maria N, Jacobs R, Urata M, Wang H, Zlokovic BV, Chen JF, Chai Y. PMID: 33417861.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Comparison Between Blood-Brain Barrier Water Exchange Rate and Permeability to Gadolinium-Based Contrast Agent in an Elderly Cohort. Front Neurosci. 2020; 14:571480. Shao X, Jann K, Ma SJ, Yan L, Montagne A, Ringman JM, Zlokovic BV, Wang DJJ. PMID: 33328848.
      View in: PubMed   Mentions:
    13. Endothelial Tip Cell Finds Its Way with Piezo1. Neuron. 2020 10 14; 108(1):5-7. Zhao Z, Zlokovic BV. PMID: 33058766.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid. J Neurosci. 2020 10 28; 40(44):8573-8586. Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Conti P, Jann K, Pa J. PMID: 33046556.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020 12; 16(12):1714-1733. Zlokovic BV, Gottesman RF, Bernstein KE, Seshadri S, McKee A, Snyder H, Greenberg SM, Yaffe K, Schaffer CB, Yuan C, Hughes TM, Daemen MJ, Williamson JD, González HM, Schneider J, Wellington CL, Katusic ZS, Stoeckel L, Koenig JI, Corriveau RA, Fine L, Galis ZS, Reis J, Wright JD, Chen J. PMID: 33030307.
      View in: PubMed   Mentions: 12     Fields:    
    16. A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease. Transl Stroke Res. 2021 02; 12(1):15-30. Stringer MS, Lee H, Huuskonen MT, MacIntosh BJ, Brown R, Montagne A, Atwi S, Ramirez J, Jansen MA, Marshall I, Black SE, Zlokovic BV, Benveniste H, Wardlaw JM. PMID: 32936435.
      View in: PubMed   Mentions: 3     Fields:    
    17. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA): Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease-Opportunities for Therapy. Alzheimers Dement (Amst). 2020; 12(1):e12053. Carare RO, Aldea R, Agarwal N, Bacskai BJ, Bechman I, Boche D, Bu G, Bulters D, Clemens A, Counts SE, de Leon M, Eide PK, Fossati S, Greenberg SM, Hamel E, Hawkes CA, Koronyo-Hamaoui M, Hainsworth AH, Holtzman D, Ihara M, Jefferson A, Kalaria RN, Kipps CM, Kanninen KM, Leinonen V, McLaurin J, Miners S, Malm T, Nicoll JAR, Piazza F, Paul G, Rich SM, Saito S, Shih A, Scholtzova H, Snyder H, Snyder P, Thormodsson FR, van Veluw SJ, Weller RO, Werring DJ, Wilcock D, Wilson MR, Zlokovic BV, Verma A. PMID: 32775596.
      View in: PubMed   Mentions:
    18. Therapeutic TVs for Crossing Barriers in the Brain. Cell. 2020 07 23; 182(2):267-269. Zhao Z, Zlokovic BV. PMID: 32707092.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    19. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine. 2020 Sep; 59:102883. Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. PMID: 32690472.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(7):e0236379. Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32663228.
      View in: PubMed   Mentions:    Fields:    
    21. 3K3A-Activated Protein C Variant Does Not Interfere With the Plasma Clot Lysis Activity of Tenecteplase. Stroke. 2020 07; 51(7):2236-2239. Mukherjee P, Lyden P, Fernández JA, Davis TP, Pryor KE, Zlokovic BV, Griffin JH. PMID: 32568648.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature. Lab Anim (NY). 2020 06; 49(6):175-176. Kisler K, Huuskonen MT, Zlokovic BV. PMID: 32424313.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    23. Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(5):e0232785. Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32469871.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954.
      View in: PubMed   Mentions: 134     Fields:    Translation:HumansCells
    25. Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo. Front Aging Neurosci. 2020; 12:108. Nelson AR, Sagare MA, Wang Y, Kisler K, Zhao Z, Zlokovic BV. PMID: 32410982.
      View in: PubMed   Mentions:
    26. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020 06; 16(6):821-830. Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. PMID: 32301266.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    27. Perivascular spaces in the brain: anatomy, physiology and pathology. Nat Rev Neurol. 2020 03; 16(3):137-153. Wardlaw JM, Benveniste H, Nedergaard M, Zlokovic BV, Mestre H, Lee H, Doubal FN, Brown R, Ramirez J, MacIntosh BJ, Tannenbaum A, Ballerini L, Rungta RL, Boido D, Sweeney M, Montagne A, Charpak S, Joutel A, Smith KJ, Black SE, colleagues from the Fondation Leducq Transatlantic Network of Excellence on the Role of the Perivasc . PMID: 32094487.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimals
    28. APOE4 Accelerates Development of Dementia After Stroke: Is There a Role for Cerebrovascular Dysfunction? Stroke. 2020 03; 51(3):699-700. Montagne A, Nation DA, Zlokovic BV. PMID: 32070225.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling. Front Cell Neurosci. 2020; 14:27. Kisler K, Nikolakopoulou AM, Sweeney MD, Lazic D, Zhao Z, Zlokovic BV. PMID: 32116568.
      View in: PubMed   Mentions:
    30. Every-other-day feeding exacerbates inflammation and neuronal deficits in 5XFAD mouse model of Alzheimer's disease. Neurobiol Dis. 2020 03; 136:104745. Lazic D, Tesic V, Jovanovic M, Brkic M, Milanovic D, Zlokovic BV, Kanazir S, Perovic M. PMID: 31931140.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 12; 15(12):1568-1575. Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 31862169.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers. Neurobiol Aging. 2020 02; 86:112-122. Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. PMID: 31870643.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22; 1747493019871915. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. PMID: 31543058.
      View in: PubMed   Mentions: 3     Fields:    
    34. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 10 03; 25(4):486-500.e9. Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. PMID: 31523028.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    35. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. PMID: 31310593.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    36. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 07; 15(7):961-984. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. PMID: 31327392.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    37. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. PMID: 31235908.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    38. Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis. . 2019 08 01; 317(2):H255-H263. Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ. PMID: 31125259.
      View in: PubMed   Mentions:
    39. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS One. 2019; 14(5):e0216726. Jovic M, Loncarevic-Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, Kanazir S. PMID: 31095617.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    40. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2019 04 09; 27(2):549-560.e6. Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. PMID: 30970257.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76. Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. PMID: 30661727.
      View in: PubMed   Mentions: 1     Fields:    
    42. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. PMID: 30647119.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    43. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 30643288.
      View in: PubMed   Mentions: 260     Fields:    Translation:Humans
    44. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136. Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators . PMID: 30450637.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    45. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. PMID: 30642436.
      View in: PubMed   Mentions: 122     Fields:    Translation:Humans
    46. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 01 01; 99(1):21-78. Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. PMID: 30280653.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimalsCells
    47. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018 10 19; 13(1):57. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 30340601.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    48. The role of brain vasculature in neurodegenerative disorders. Nat Neurosci. 2018 10; 21(10):1318-1331. Sweeney MD, Kisler K, Montagne A, Toga AW, Zlokovic BV. PMID: 30250261.
      View in: PubMed   Mentions: 161     Fields:    Translation:HumansAnimals
    49. Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovasc Res. 2018 09 01; 114(11):1462-1473. Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM. PMID: 29726891.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimals
    50. A lymphatic waste-disposal system implicated in Alzheimer's disease. Nature. 2018 08; 560(7717):172-174. Sweeney MD, Zlokovic BV. PMID: 30076374.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    51. Activated protein C, protease activated receptor 1, and neuroprotection. Blood. 2018 07 12; 132(2):159-169. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 29866816.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    52. Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol. Neurosurgery. 2018 06 01; 82(6):770-780. Netto JP, Iliff J, Stanimirovic D, Krohn KA, Hamilton B, Varallyay C, Gahramanov S, Daldrup-Link H, d'Esterre C, Zlokovic B, Sair H, Lee Y, Taheri S, Jain R, Panigrahy A, Reich DS, Drewes LR, Castillo M, Neuwelt EA. PMID: 28973554.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    53. In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain. Nat Protoc. 2018 06; 13(6):1377-1402. Kisler K, Lazic D, Sweeney MD, Plunkett S, El Khatib M, Vinogradov SA, Boas DA, Sakadži S, Zlokovic BV. PMID: 29844521.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    54. Permeability imaging as a predictor of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2018 06; 38(6):973-979. Russin JJ, Montagne A, D'Amore F, He S, Shiroishi MS, Rennert RC, Depetris J, Zlokovic BV, Mack WJ. PMID: 29611451.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    55. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimalsCells
    56. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    57. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 03; 14(3):133-150. Sweeney MD, Sagare AP, Zlokovic BV. PMID: 29377008.
      View in: PubMed   Mentions: 398     Fields:    Translation:Humans
    58. PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke. Blood. 2018 03 15; 131(11):1163-1171. Sinha RK, Wang Y, Zhao Z, Xu X, Burnier L, Gupta N, Fernández JA, Martin G, Kupriyanov S, Mosnier LO, Zlokovic BV, Griffin JH. PMID: 29343482.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    59. Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum. J Cereb Blood Flow Metab. 2019 02; 39(2):240-250. Liu Q, Radwanski R, Babadjouni R, Patel A, Hodis DM, Baumbacher P, Zhao Z, Zlokovic B, Mack WJ. PMID: 29192539.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    60. Alzheimer's disease: A matter of blood-brain barrier dysfunction? J Exp Med. 2017 Nov 06; 214(11):3151-3169. Montagne A, Zhao Z, Zlokovic BV. PMID: 29061693.
      View in: PubMed   Mentions: 145     Fields:    Translation:HumansAnimals
    61. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    62. Role of clusterin in the brain vascular clearance of amyloid-β. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. Nelson AR, Sagare AP, Zlokovic BV. PMID: 28765369.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    63. Remote control of BBB: A tale of exosomes and microRNA. Cell Res. 2017 07; 27(7):849-850. Zhao Z, Zlokovic BV. PMID: 28674430.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    64. Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease. Nat Rev Neurosci. 2017 07; 18(7):419-434. Kisler K, Nelson AR, Montagne A, Zlokovic BV. PMID: 28515434.
      View in: PubMed   Mentions: 234     Fields:    Translation:Humans
    65. NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017 May 01; 14(1):12. Ochocinska MJ, Zlokovic BV, Searson PC, Crowder AT, Kraig RP, Ljubimova JY, Mainprize TG, Banks WA, Warren RQ, Kindzelski A, Timmer W, Liu CH. PMID: 28457227.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    66. Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling. PLoS One. 2017; 12(4):e0176225. Nikolakopoulou AM, Zhao Z, Montagne A, Zlokovic BV. PMID: 28441414.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    67. Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nat Neurosci. 2017 Mar; 20(3):406-416. Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV. PMID: 28135240.
      View in: PubMed   Mentions: 132     Fields:    Translation:AnimalsCells
    68. 2016 Scientific Sessions Sol Sherry Distinguished Lecturer in Thrombosis: Thrombotic Stroke: Neuroprotective Therapy by Recombinant-Activated Protein C. Arterioscler Thromb Vasc Biol. 2016 11; 36(11):2143-2151. Griffin JH, Mosnier LO, Fernández JA, Zlokovic BV. PMID: 27758767.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    69. 3K3A-activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice. Nat Med. 2016 09; 22(9):1050-5. Wang Y, Zhao Z, Rege SV, Wang M, Si G, Zhou Y, Wang S, Griffin JH, Goldman SA, Zlokovic BV. PMID: 27548576.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    70. Zika Virus NS4A and NS4B Proteins Deregulate Akt-mTOR Signaling in Human Fetal Neural Stem Cells to Inhibit Neurogenesis and Induce Autophagy. Cell Stem Cell. 2016 11 03; 19(5):663-671. Liang Q, Luo Z, Zeng J, Chen W, Foo SS, Lee SA, Ge J, Wang S, Goldman SA, Zlokovic BV, Zhao Z, Jung JU. PMID: 27524440.
      View in: PubMed   Mentions: 167     Fields:    Translation:HumansAnimalsCells
    71. Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci. 2016 05 26; 19(6):771-83. Sweeney MD, Ayyadurai S, Zlokovic BV. PMID: 27227366.
      View in: PubMed   Mentions: 238     Fields:    Translation:HumansAnimalsCells
    72. Activated protein C promotes neuroprotection: mechanisms and translation to the clinic. Thromb Res. 2016 May; 141 Suppl 2:S62-4. Griffin JH, Fernández JA, Lyden PD, Zlokovic BV. PMID: 27207428.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    73. Brain imaging of neurovascular dysfunction in Alzheimer's disease. Acta Neuropathol. 2016 May; 131(5):687-707. Montagne A, Nation DA, Pa J, Sweeney MD, Toga AW, Zlokovic BV. PMID: 27038189.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimals
    74. Clearance systems in the brain--implications for Alzheimer diseaser. Nat Rev Neurol. 2016 Apr; 12(4):248. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. PMID: 27020556.
      View in: PubMed   Mentions: 14     Fields:    
    75. Neurovascular and Immuno-Imaging: From Mechanisms to Therapies. Proceedings of the Inaugural Symposium. Front Neurosci. 2016; 10:46. Akassoglou K, Agalliu D, Chang CJ, Davalos D, Grutzendler J, Hillman EM, Khakh BS, Kleinfeld D, McGavern DB, Nelson SJ, Zlokovic BV. PMID: 26941593.
      View in: PubMed   Mentions:
    76. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. PMID: 26198175.
      View in: PubMed   Mentions: 63     Fields:    Translation:Humans
    77. Accelerated pericyte degeneration and blood-brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer's disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):216-27. Halliday MR, Rege SV, Ma Q, Zhao Z, Miller CA, Winkler EA, Zlokovic BV. PMID: 25757756.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansCells
    78. Blood-Brain Barrier Permeability and Gadolinium: Benefits and Potential Pitfalls in Research. JAMA Neurol. 2016 Jan; 73(1):13-4. Montagne A, Toga AW, Zlokovic BV. PMID: 26524294.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    79. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900. Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. PMID: 26705676.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimals
    80. Establishment and Dysfunction of the Blood-Brain Barrier. Cell. 2015 Nov 19; 163(5):1064-1078. Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV. PMID: 26590417.
      View in: PubMed   Mentions: 411     Fields:    Translation:HumansAnimalsCells
    81. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101. Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. PMID: 26407747.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    82. Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke. Front Cell Neurosci. 2015; 9:344. Amar AP, Griffin JH, Zlokovic BV. PMID: 26388732.
      View in: PubMed   Mentions:
    83. Clearance systems in the brain-implications for Alzheimer disease. Nat Rev Neurol. 2015 Aug; 11(8):457-70. Tarasoff-Conway JM, Carare RO, Osorio RS, Glodzik L, Butler T, Fieremans E, Axel L, Rusinek H, Nicholson C, Zlokovic BV, Frangione B, Blennow K, Ménard J, Zetterberg H, Wisniewski T, de Leon MJ. PMID: 26195256.
      View in: PubMed   Mentions: 353     Fields:    Translation:HumansCells
    84. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. PMID: 26236233.
      View in: PubMed   Mentions:
    85. ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies. BMC Med Imaging. 2015 Jun 16; 15:19. Barnes SR, Ng TS, Santa-Maria N, Montagne A, Zlokovic BV, Jacobs RE. PMID: 26076957.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    86. Optimal acquisition and modeling parameters for accurate assessment of low Ktrans blood-brain barrier permeability using dynamic contrast-enhanced MRI. Magn Reson Med. 2016 May; 75(5):1967-77. Barnes SR, Ng TS, Montagne A, Law M, Zlokovic BV, Jacobs RE. PMID: 26077645.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    87. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    88. Vascular plasticity and cognition during normal aging and dementia. JAMA Neurol. 2015 May; 72(5):495-6. Montagne A, Pa J, Zlokovic BV. PMID: 25751405.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    89. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. Sweeney MD, Sagare AP, Zlokovic BV. PMID: 25899298.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    90. Activated protein C: biased for translation. Blood. 2015 May 07; 125(19):2898-907. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 25824691.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    91. 7T Multi-shell Hybrid Diffusion Imaging (HYDI) for Mapping Brain Connectivity in Mice. Proc SPIE Int Soc Opt Eng. 2015 Mar 20; 9413. Daianu M, Jahanshad N, Villalon-Reina JE, Prasad G, Jacobs RE, Barnes S, Zlokovic BV, Montagne A, Thompson PM. PMID: 25859293.
      View in: PubMed   Mentions:
    92. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. PMID: 25730668.
      View in: PubMed   Mentions: 163     Fields:    Translation:Animals
    93. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. PMID: 25611508.
      View in: PubMed   Mentions: 525     Fields:    Translation:HumansCells
    94. Vascular contributions to cognitive impairment and dementia including Alzheimer's disease. Alzheimers Dement. 2015 Jun; 11(6):710-7. Snyder HM, Corriveau RA, Craft S, Faber JE, Greenberg SM, Knopman D, Lamb BT, Montine TJ, Nedergaard M, Schaffer CB, Schneider JA, Wellington C, Wilcock DM, Zipfel GJ, Zlokovic B, Bain LJ, Bosetti F, Galis ZS, Koroshetz W, Carrillo MC. PMID: 25510382.
      View in: PubMed   Mentions: 194     Fields:    Translation:HumansAnimals
    95. Cytoprotective-selective activated protein C therapy for ischaemic stroke. Thromb Haemost. 2014 Nov; 112(5):883-92. Mosnier LO, Zlokovic BV, Griffin JH. PMID: 25230930.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    96. Negative regulation of NF-κB activity by brain-specific TRIpartite Motif protein 9. Nat Commun. 2014 Sep 05; 5:4820. Shi M, Cho H, Inn KS, Yang A, Zhao Z, Liang Q, Versteeg GA, Amini-Bavil-Olyaee S, Wong LY, Zlokovic BV, Park HS, García-Sastre A, Jung JU. PMID: 25190485.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    97. Recommendations of the Alzheimer's disease-related dementias conference. Neurology. 2014 Aug 26; 83(9):851-60. Montine TJ, Koroshetz WJ, Babcock D, Dickson DW, Galpern WR, Glymour MM, Greenberg SM, Hutton ML, Knopman DS, Kuzmichev AN, Manly JJ, Marder KS, Miller BL, Phelps CH, Seeley WW, Sieber BA, Silverberg NB, Sutherland M, Torborg CL, Waddy SP, Zlokovic BV, Corriveau RA, ADRD 2013 Conference Organizing Committee . PMID: 25080517.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    98. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR, Winkler EA, Sagare AP, Zlokovic BV. PMID: 24946075; PMCID: PMC4423607.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    99. Blood-brain barrier: a dual life of MFSD2A? Neuron. 2014 May 21; 82(4):728-30. Zhao Z, Zlokovic BV. PMID: 24853933.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    100. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. PMID: 24591593.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    101. Influence of the 3K3A-activated protein C variant on the plasma clot lysis activity of t-PA and of t-PA on the variant's anticoagulant activity. J Thromb Haemost. 2013 Nov; 11(11):2059-62. Mosnier LO, Fernández JA, Davis TP, Zlokovic BV, Griffin JH. PMID: 24034518.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    102. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats. Stroke. 2013 Dec; 44(12):3529-36. Wang Y, Zhao Z, Chow N, Rajput PS, Griffin JH, Lyden PD, Zlokovic BV. PMID: 24159062.
      View in: PubMed   Mentions: 32     Fields:    Translation:Animals
    103. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200. Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. PMID: 24030206.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    104. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. PMID: 23580652.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    105. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. J Neurosci. 2013 Apr 03; 33(14):6181-90. Guo H, Zhao Z, Yang Q, Wang M, Bell RD, Wang S, Chow N, Davis TP, Griffin JH, Goldman SA, Zlokovic BV. PMID: 23554499.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    106. Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease. JAMA Neurol. 2013 Apr; 70(4):440-4. Zlokovic BV. PMID: 23400708.
      View in: PubMed   Mentions: 99     Fields:    Translation:HumansAnimals
    107. Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice. Blood Cells Mol Dis. 2013 Aug; 51(2):104-8. Wang Y, Sinha RK, Mosnier LO, Griffin JH, Zlokovic BV. PMID: 23541526.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    108. A gliovascular idea for the white matter repair? J Neurochem. 2013 Apr; 125(2):172-4. Zlokovic BV. PMID: 23441580.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    109. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1. Brain Res. 2013 Apr 24; 1507:97-104. Wang Y, Zhao Z, Chow N, Ali T, Griffin JH, Zlokovic BV. PMID: 23438513.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    110. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013; 4:2932. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 24336108.
      View in: PubMed   Mentions: 214     Fields:    Translation:AnimalsCells
    111. Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. Sagare AP, Bell RD, Zlokovic BV. PMID: 22751174.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    112. Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers. Curr Pharm Des. 2013; 19(42):7479-85. Lyden P, Levy H, Weymer S, Pryor K, Kramer W, Griffin JH, Davis TP, Zlokovic B. PMID: 24372304.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCTClinical Trials
    113. Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease. Brain Pathol. 2013 May; 23(3):303-10. Sengillo JD, Winkler EA, Walker CT, Sullivan JS, Johnson M, Zlokovic BV. PMID: 23126372.
      View in: PubMed   Mentions: 159     Fields:    Translation:HumansCells
    114. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). Sagare AP, Bell RD, Zlokovic BV. PMID: 23028132.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimals
    115. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis. Acta Neuropathol. 2013 Jan; 125(1):111-20. Winkler EA, Sengillo JD, Sullivan JS, Henkel JS, Appel SH, Zlokovic BV. PMID: 22941226.
      View in: PubMed   Mentions: 122     Fields:    Translation:HumansCells
    116. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15502-7. Castellano JM, Deane R, Gottesdiener AJ, Verghese PB, Stewart FR, West T, Paoletti AC, Kasper TR, DeMattos RB, Zlokovic BV, Holtzman DM. PMID: 22927427.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    117. Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability. J Cereb Blood Flow Metab. 2012 Oct; 32(10):1841-52. Winkler EA, Sengillo JD, Bell RD, Wang J, Zlokovic BV. PMID: 22850407.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    118. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 2012 Oct; 136(1):94-105. Sagare AP, Deane R, Zlokovic BV. PMID: 22820095.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimals
    119. An activated protein C analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents. Stroke. 2012 Sep; 43(9):2444-9. Wang Y, Zhang Z, Chow N, Davis TP, Griffin JH, Chopp M, Zlokovic BV. PMID: 22811462.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    120. Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature. Hypertension. 2012 Jul; 60(1):188-97. Carnevale D, Mascio G, D'Andrea I, Fardella V, Bell RD, Branchi I, Pallante F, Zlokovic B, Yan SS, Lembo G. PMID: 22615109.
      View in: PubMed   Mentions: 77     Fields:    Translation:Animals
    121. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 16; 485(7399):512-6. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 22622580.
      View in: PubMed   Mentions: 455     Fields:    Translation:HumansAnimalsCells
    122. Protein C anticoagulant and cytoprotective pathways. Int J Hematol. 2012 Apr; 95(4):333-45. Griffin JH, Zlokovic BV, Mosnier LO. PMID: 22477541.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    123. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92. Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. PMID: 22406537.
      View in: PubMed   Mentions: 196     Fields:    Translation:HumansAnimalsCells
    124. Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke. Curr Pharm Des. 2012; 18(27):4215-22. Williams PD, Zlokovic BV, Griffin JH, Pryor KE, Davis TP. PMID: 22632606.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    125. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011 Nov 03; 12(12):723-38. Zlokovic BV. PMID: 22048062.
      View in: PubMed   Mentions: 864     Fields:    Translation:HumansAnimalsCells
    126. Central nervous system pericytes in health and disease. Nat Neurosci. 2011 Oct 26; 14(11):1398-1405. Winkler EA, Bell RD, Zlokovic BV. PMID: 22030551.
      View in: PubMed   Mentions: 350     Fields:    Translation:HumansCells
    127. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res. 2011 Jul; 89(7):967-8. Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. PMID: 21544850.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    128. Microhemorrhages: undetectable but clinically meaningful the question persists. Amyotroph Lateral Scler. 2011 May; 12(3):231-2; author reply 233-4. Zhong Z, Winkler EA, Zlokovic BV. PMID: 21413850.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    129. Lack of Smad or Notch leads to a fatal game of brain pericyte hopscotch. Dev Cell. 2011 Mar 15; 20(3):279-80. Winkler EA, Bell RD, Zlokovic BV. PMID: 21397835.
      View in: PubMed   Mentions: 12     Fields:    
    130. Cytoprotective protein C pathways and implications for stroke and neurological disorders. Trends Neurosci. 2011 Apr; 34(4):198-209. Zlokovic BV, Griffin JH. PMID: 21353711.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimalsCells
    131. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener. 2011 Feb 03; 6:13. Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21291561.
      View in: PubMed   Mentions: 10     Fields:    
    132. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis. 2011; 24(1):25-34. Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. PMID: 21157031.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    133. Methamphetamine causes sustained depression in cerebral blood flow. Brain Res. 2011 Feb 10; 1373:91-100. Polesskaya O, Silva J, Sanfilippo C, Desrosiers T, Sun A, Shen J, Feng C, Polesskiy A, Deane R, Zlokovic B, Kasischke K, Dewhurst S. PMID: 21156163.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    134. Neurodegeneration and the neurovascular unit. Nat Med. 2010 Dec; 16(12):1370-1. Zlokovic BV. PMID: 21135839.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    135. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21084607.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    136. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 21040844.
      View in: PubMed   Mentions: 538     Fields:    Translation:AnimalsCells
    137. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. PMID: 20854368.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimals
    138. Pericyte constriction after stroke: the jury is still out. Nat Med. 2010 Sep; 16(9):959; author reply 960. Vates GE, Takano T, Zlokovic B, Nedergaard M. PMID: 20823870.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    139. Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling. Mol Neurodegener. 2010 Aug 25; 5:32. Winkler EA, Bell RD, Zlokovic BV. PMID: 20738866.
      View in: PubMed   Mentions: 113     Fields:    
    140. Activated protein C analog with reduced anticoagulant activity improves functional recovery and reduces bleeding risk following controlled cortical impact. Brain Res. 2010 Aug 06; 1347:125-31. Walker CT, Marky AH, Petraglia AL, Ali T, Chow N, Zlokovic BV. PMID: 20513369.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    141. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72. Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. PMID: 20348395.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    142. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. PMID: 20043896.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    143. Activated protein C is neuroprotective and mediates new blood vessel formation and neurogenesis after controlled cortical impact. Neurosurgery. 2010 Jan; 66(1):165-71; discussion 171-2. Petraglia AL, Marky AH, Walker C, Thiyagarajan M, Zlokovic BV. PMID: 20023547.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    144. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest. 2009 Nov; 119(11):3437-49. Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. PMID: 19841542.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    145. Species-specific anticoagulant and mitogenic activities of murine protein S. Haematologica. 2009 Dec; 94(12):1721-31. Fernández JA, Heeb MJ, Xu X, Singh I, Zlokovic BV, Griffin JH. PMID: 19815836.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    146. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol. 2009 Jul; 118(1):103-13. Bell RD, Zlokovic BV. PMID: 19319544.
      View in: PubMed   Mentions: 304     Fields:    Translation:HumansAnimalsCells
    147. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. Deane R, Bell RD, Sagare A, Zlokovic BV. PMID: 19275634.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimals
    148. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity. Eur J Neurosci. 2009 Mar; 29(6):1119-30. Guo H, Singh I, Wang Y, Deane R, Barrett T, Fernández JA, Chow N, Griffin JH, Zlokovic BV. PMID: 19302148.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    149. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity. J Neurochem. 2009 Apr; 109(1):116-24. Guo H, Wang Y, Singh I, Liu D, Fernández JA, Griffin JH, Chow N, Zlokovic BV. PMID: 19166505.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    150. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53. Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 19098903.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimalsCells
    151. Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity. Stroke. 2009 May; 40(5):1864-9. Wang Y, Thiyagarajan M, Chow N, Singh I, Guo H, Davis TP, Zlokovic BV. PMID: 19057019.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    152. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. PMID: 19036971.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    153. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. PMID: 19033669.
      View in: PubMed   Mentions: 292     Fields:    Translation:HumansAnimalsCells
    154. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. PMID: 18841163.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    155. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008 Jul; 5(3):409-14. Zlokovic BV. PMID: 18625452.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimals
    156. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. PMID: 18451334.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    157. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. PMID: 18344992.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    158. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008 Jan 24; 57(2):178-201. Zlokovic BV. PMID: 18215617.
      View in: PubMed   Mentions: 1056     Fields:    Translation:HumansAnimals
    159. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5. Deane R, Sagare A, Zlokovic BV. PMID: 18673201.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimals
    160. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008 Apr; 28(4):764-71. Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, Gregg SR, Wu Z, Jiang A, Lu M, Zlokovic BV, Chopp M. PMID: 17971789.
      View in: PubMed   Mentions: 110     Fields:    Translation:AnimalsCells
    161. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. PMID: 17694066.
      View in: PubMed   Mentions: 166     Fields:    Translation:HumansAnimals
    162. Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease. Curr Alzheimer Res. 2007 Apr; 4(2):191-7. Deane R, Zlokovic BV. PMID: 17430246.
      View in: PubMed   Mentions: 130     Fields:    Translation:HumansAnimals
    163. Endothelial cell protein C receptor: role beyond endothelium? Circ Res. 2007 Feb 02; 100(2):155-7. Thiyagarajan M, Cheng T, Zlokovic BV. PMID: 17272817.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    164. Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann N Y Acad Sci. 2007 Feb; 1097:40-50. Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. PMID: 17413008.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    165. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 17215356.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    166. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. Mosnier LO, Zlokovic BV, Griffin JH. PMID: 17110453.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansAnimals
    167. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. PMID: 17077814.
      View in: PubMed   Mentions: 240     Fields:    Translation:HumansAnimals
    168. Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat Med. 2006 Nov; 12(11):1278-85. Cheng T, Petraglia AL, Li Z, Thiyagarajan M, Zhong Z, Wu Z, Liu D, Maggirwar SB, Deane R, Fernández JA, LaRue B, Griffin JH, Chopp M, Zlokovic BV. PMID: 17072311.
      View in: PubMed   Mentions: 117     Fields:    Translation:AnimalsCells
    169. Remodeling after stroke. Nat Med. 2006 Apr; 12(4):390-1. Zlokovic BV. PMID: 16598283.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    170. The promise of protein C. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):211-6. Griffin JH, Fernández JA, Mosnier LO, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 16464623.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    171. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. PMID: 16354907.
      View in: PubMed   Mentions: 93     Fields:    Translation:HumansAnimals
    172. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. PMID: 16239972.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    173. Functional recovery after embolic stroke in rodents by activated protein C. Ann Neurol. 2005 Sep; 58(3):474-7. Zlokovic BV, Zhang C, Liu D, Fernandez J, Griffin JH, Chopp M. PMID: 16130108.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    174. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. PMID: 16116430.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansAnimalsCells
    175. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr; 28(4):202-8. Zlokovic BV. PMID: 15808355.
      View in: PubMed   Mentions: 312     Fields:    Translation:HumansAnimals
    176. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. . 2005 Aug; 289(2):C264-76. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. PMID: 15743889.
      View in: PubMed   Mentions:
    177. Neurovascular pathways and Alzheimer amyloid beta-peptide. Brain Pathol. 2005 Jan; 15(1):78-83. Zlokovic BV, Deane R, Sallstrom J, Chow N, Miano JM. PMID: 15779240.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimals
    178. Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nat Med. 2004 Dec; 10(12):1379-83. Liu D, Cheng T, Guo H, Fernández JA, Griffin JH, Song X, Zlokovic BV. PMID: 15516929.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    179. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. PMID: 15325132.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    180. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. Deane R, Wu Z, Zlokovic BV. PMID: 15459432.
      View in: PubMed   Mentions: 136     Fields:    Translation:HumansAnimals
    181. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. PMID: 15294142.
      View in: PubMed   Mentions: 337     Fields:    Translation:HumansAnimalsCells
    182. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16. Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. PMID: 15183014.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    183. Clearing amyloid through the blood-brain barrier. J Neurochem. 2004 May; 89(4):807-11. Zlokovic BV. PMID: 15140180.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimals
    184. Activated protein C and ischemic stroke. Crit Care Med. 2004 May; 32(5 Suppl):S247-53. Griffin JH, Fernández JA, Liu D, Cheng T, Guo H, Zlokovic BV. PMID: 15118526.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    185. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 07; 279(19):20296-306. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. PMID: 14985348.
      View in: PubMed   Mentions: 168     Fields:    Translation:HumansAnimalsCells
    186. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. PMID: 14980205.
      View in: PubMed   Mentions: 102     Fields:    Translation:AnimalsCells
    187. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004 Feb; 88(4):813-20. Deane R, Zheng W, Zlokovic BV. PMID: 14756801.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    188. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. Wu Z, Hofman FM, Zlokovic BV. PMID: 14583404.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    189. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. PMID: 12808450.
      View in: PubMed   Mentions: 487     Fields:    Translation:HumansAnimals
    190. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. PMID: 12737945.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    191. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. PMID: 12665496.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    192. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. PMID: 12586611.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    193. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. PMID: 12563316.
      View in: PubMed   Mentions: 193     Fields:    Translation:HumansAnimalsCells
    194. Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. Amar AP, Zlokovic BV, Apuzzo ML. PMID: 12535371.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    195. Current treatments and therapeutic targets in Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7. Zlokovic BV. PMID: 12453670.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    196. Vascular disorder in Alzheimer's disease: role in pathogenesis of dementia and therapeutic targets. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1553-9. Zlokovic BV. PMID: 12453672.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    197. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. . 2002 Sep; 283(3):C895-904. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. PMID: 12176746.
      View in: PubMed   Mentions:
    198. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. Griffin JH, Zlokovic B, Fernández JA. PMID: 12124682.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    199. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun; 38(6):303-13. Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. PMID: 12529925.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimals
    200. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target. 2002 Jun; 10(4):359-68. Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. PMID: 12164385.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    201. The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2002 Jun; 4(3):217-23. Grammas P, Yamada M, Zlokovic B. PMID: 12226540.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    202. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun; 23(3):405-12. Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. PMID: 11959403.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    203. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. PMID: 11311331.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    204. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2001 May; 48(5):1196-7. Zlokovic BV, Cox C. PMID: 11334298.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    205. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. PMID: 11282913.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
    206. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001 Jan; 48(1):151-7. MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. PMID: 11152340.
      View in: PubMed   Mentions: 71     Fields:    Translation:HumansAnimals
    207. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. . 2000 Dec; 279(6):C1772-81. Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. PMID: 11078691.
      View in: PubMed   Mentions:
    208. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec; 106(12):1489-99. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. PMID: 11120756.
      View in: PubMed   Mentions: 451     Fields:    Translation:HumansAnimalsCells
    209. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech. 2000 Aug 15; 50(4):305-15. Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. PMID: 10936885.
      View in: PubMed   Mentions: 76     Fields:    Translation:Humans
    210. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. PMID: 10899440.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    211. Clearance of amyloid beta-peptide from brain: transport or metabolism? Nat Med. 2000 Jul; 6(7):718-9. Zlokovic BV, Yamada S, Holtzman D, Ghiso J, Frangione B. PMID: 10888892.
      View in: PubMed   Mentions: 68     Fields:    
    212. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 01; 348 Pt 2:359-65. Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. PMID: 10816430.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    213. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. PMID: 10894183.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    214. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000 Apr; 141(4):1434-41. Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. PMID: 10746647.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    215. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999 Dec 01; 344 Pt 2:375-83. Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. PMID: 10567218.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    216. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. PMID: 10559029.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    217. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. PMID: 10515502.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    218. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett. 1999 Sep 10; 272(2):127-30. Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. PMID: 10507558.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    219. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res. 1999 Sep; 16(9):1360-5. Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. PMID: 10496650.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    220. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea. 1999 May; 18(3):321-7. Kannan R, Mackic JB, Zlokovic BV. PMID: 10336036.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    221. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol. 1999 May; 157(1):194-201. Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. PMID: 10222122.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    222. Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec 01; 92(5):213-9. Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. PMID: 9851812.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    223. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. PMID: 9848858.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    224. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery. 1998 Oct; 43(4):909-13. Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. PMID: 9766319.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    225. Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998 Oct; 43(4):877-8. Zlokovic BV, Apuzzo ML. PMID: 9766315.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    226. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug 15; 91(4):191-7. Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. PMID: 9736422.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    227. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. PMID: 9710442.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansCells
    228. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther. 1998 May 01; 9(7):989-95. LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. PMID: 9607410.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    229. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan; 70(1):210-5. Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. PMID: 9422364.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    230. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. Lavine SD, Hofman FM, Zlokovic BV. PMID: 9428305.
      View in: PubMed   Mentions: 48     Fields:    Translation:Animals
    231. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. J Neurosurg. 1997 Nov; 87(5):731-7. Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. PMID: 9347982.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    232. Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. PMID: 9409303.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    233. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem. 1997 Nov; 69(5):1995-2004. Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. PMID: 9349544.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    234. Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 1997 Jun 15; 2(6):e5. Zlokovic BV. PMID: 15099052.
      View in: PubMed   Mentions: 4     Fields:    
    235. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 9227280.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    236. Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. Zlokovic BV, Apuzzo ML. PMID: 9092853.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    237. Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. Zlokovic BV, Apuzzo ML. PMID: 9092854.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    238. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs. Curr Eye Res. 1997 Apr; 16(4):365-71. Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. PMID: 9134326.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    239. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. PMID: 9040492.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    240. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharm Res. 1997 Jan; 14(1):80-5. Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. PMID: 9034225.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    241. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiol Dis. 1997; 4(1):23-6. Zlokovic B. PMID: 9258908.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    242. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. PMID: 8843923.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    243. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. PMID: 8633046.
      View in: PubMed   Mentions: 127     Fields:    Translation:AnimalsCells
    244. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. PMID: 8621654.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    245. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke. 1996 Apr; 27(4):712-9. Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. PMID: 8614937.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    246. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. PMID: 8710175.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    247. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5. Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. PMID: 8932451.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    248. Cellular uptake and transport of methylprednisolone at the blood-brain barrier. Neurosurgery. 1996 Feb; 38(2):348-54. Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. PMID: 8869063.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    249. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. PMID: 8674510.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    250. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci. 1996; 59(18):1483-97. Zlokovic BV. PMID: 8890929.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    251. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 1995 Nov; 37(5):955-61. Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. PMID: 8559345.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    252. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. PMID: 7591644.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    253. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res. 1995 Oct; 12(10):1395-406. Zlokovic BV. PMID: 8584471.
      View in: PubMed   Mentions: 45     Fields:    Translation:Animals
    254. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. PMID: 7635653.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    255. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. PMID: 8642902.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    256. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism. Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic LM. PMID: 7549442.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    257. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. PMID: 7802679.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    258. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. PMID: 7859824.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    259. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. PMID: 8198602.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    260. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. PMID: 8147886.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    261. Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. PMID: 8125742.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    262. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. PMID: 8280117.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimals
    263. The blood-brain barrier in vitro: recent progress. Neurochem Int. 1993 Dec; 23(6):523. Zlokovic BV. PMID: 8281120.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    264. Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25. Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. PMID: 8385133.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    265. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. PMID: 8384107.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    266. Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. PMID: 8384106.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    267. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. PMID: 8392783.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    268. A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Exp Eye Res. 1993 Jan; 56(1):45-50. Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. PMID: 8432334.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    269. Differential brain penetration of cerebroprotective drugs. Adv Exp Med Biol. 1993; 331:117-20. Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. PMID: 8333325.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    270. Blood-brain transport of vasopressin. Adv Exp Med Biol. 1993; 331:143-7. Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. PMID: 8333329.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    271. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res. 1992 Sep 11; 590(1-2):213-8. Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. PMID: 1422832.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    272. An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Exp Eye Res. 1992 Mar; 54(3):471-7. Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. PMID: 1381681.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    273. Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse. NIDA Res Monogr. 1992; 120:26-42. Zlokovic BV, McComb JG, Perlmutter L, Weiss MH, Davson H. PMID: 1501689.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    274. Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 1991 Nov-Dec; 32(6):783-90. Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. PMID: 1743149.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    275. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. PMID: 1902062.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    276. Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. PMID: 1899978.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    277. The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta. Agents Actions Suppl. 1991; 33:283-7. Rosic M, Collis CS, Anjelkovic IZ, Segal MB, Djuric D, Zlokovic BV. PMID: 1647128.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    278. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem. 1990 Oct; 55(4):1222-30. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, Greenwood J. PMID: 2398356.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    279. Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. PMID: 2364078.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    280. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. Segal MB, Preston JE, Collis CS, Zlokovic BV. PMID: 2186633.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    281. Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep. Endocrinol Exp. 1990 Mar; 24(1-2):29-36. Segal MB, Preston JE, Zlokovic B. PMID: 2361466.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    282. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990 Mar; 107(3):263-70. Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. PMID: 1689666.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    283. Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers. Endocrinol Exp. 1990 Mar; 24(1-2):9-17. Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG. PMID: 2193795.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    284. Immunoneurology: a serum protein afferent limb to the CNS. Adv Exp Med Biol. 1990; 274:345-70. Kozlowski GP, Nilaver G, Zlokovic BV. PMID: 2239432.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    285. Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. J Neurol Sci. 1989 Dec; 94(1-3):41-50. Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. PMID: 2515257.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    286. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem. 1989 Nov; 53(5):1333-40. Zlokovic BV, Mackic JB, Djuricic B, Davson H. PMID: 2795003.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    287. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. PMID: 2548879.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    288. Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis. 1989 Mar; 4(1):33-40. Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H, et al. PMID: 2495422.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    289. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989 Mar-Apr; 10(2):249-54. Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. PMID: 2547200.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    290. Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metab Brain Dis. 1989 Mar; 4(1):9-15. Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. PMID: 2495423.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    291. Neutral amino acid uptake by the isolated perfused sheep choroid plexus. J Physiol. 1989 Jan; 408:31-43. Preston JE, Segal MB, Walley GJ, Zlokovic BV. PMID: 2506339.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    292. Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem. 1988 Jul; 51(1):252-7. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3132534.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    293. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1988 May-Jun; 9(3):533-8. Zlokovic BV, Segal MB, Davson H, Jankov RM. PMID: 3420012.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    294. Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. Zlokovic BV, Andjelkovic IZ. PMID: 2460051.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    295. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept. 1988 Jan; 20(1):33-44. Zlokovic BV, Segal MB, Davson H, Mitrovic DM. PMID: 3127863.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    296. The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Exp Neurol. 1987 Nov; 98(2):436-52. Zlokovic BV, Davson H, Preston JE, Segal MB. PMID: 2444450.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    297. Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem. 1987 Jul; 49(1):310-5. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. PMID: 3585338.
      View in: PubMed   Mentions: 33     Fields:    
    298. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J Neurochem. 1986 May; 46(5):1444-51. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM. PMID: 3083044.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    299. Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 1985 Dec 09; 358(1-2):191-9. Zlokovic BV, Segal MB, Begley DJ, Davson H, Rakic L. PMID: 3935272.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    300. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. Mann GE, Zlokovic BV, Yudilevich DL. PMID: 4041458.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    301. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985 Jun 10; 336(1):125-32. Zlokovic BV, Begley DJ, Chain-Eliash DG. PMID: 3891014.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    302. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res. 1983 Jul 18; 271(1):65-71. Zlokovic BV, Begley DJ, Chain DG. PMID: 6883121.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    303. Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol. 1982 Jul; 76(3):483-9. Andjelkovic I, Zlokovic B. PMID: 6179557.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    Berislav's Networks
    Concepts (913)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (60)
    People in Profiles who have published with this person.
    Explore
    _
    Same Department
    Search Department
    _

    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

    This site is running Profiles RNS version v3.1.0-865-g7865d7b0 on PROFILES-PWEB02.