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Berislav V Zlokovic, MD, PhD

Title(s)Chair and Professor of Physiology & Neuroscience
Phone+1 323 442 2722
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    Other Positions
    Title(s)Mary Hayley and Selim Zilkha Chair in Alzheimer's Disease Research

    Title(s)Director, Zilkha Neurogenetic Institute


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    Collapse Overview
    Berislav V. Zlokovic is the director of the Zilkha Neurogenetic Institute and Professor and Chair of the Department of Physiology & Neuroscience at the Keck School of Medicine of USC, and a Professor of Biological Sciences at the Dornsife College of Letters, Arts and Sciences. Zlokovic studies the role of cerebral blood vessels in the pathogenesis and treatment of Alzheimer’s disease (AD), related disorders and stroke. Using animal models and studying human brain, his laboratory has shown that dysfunction in the blood-brain barrier (BBB) and brain microcirculation can accumulate before neuronal dysfunction in both synapses and nerve cells contributing to neurodegeneration, cognitive impairment and AD pathology. His group has identified molecular mechanisms at the BBB that maintain brain clearance of Alzheimer’s toxin amyloid-beta into the circulation, and its influx or re-entry from blood to brain, reflecting an important physiological function of the BBB in maintaining brain amyloid-beta homeostasis. These findings contributed to development of Phase 2/3 clinical trials for AD patients. He co-discovered with J.H. Griffin vasculoprotective, neuroprotective, and anti-inflammatory activities of activated protein C (APC), including the receptor requirements and downstream signaling pathways. These findings have been translated successfully into Phase 2 clinical trial of 3K3A-APC, a 2nd generation cytoprotective-selective APC analog, in ischemic stroke patients, which led to a Phase 3 efficacy and safety pivotal trial of 3K3A-APC in patients with ischemic stroke.

    Current research interests
    • We study humans at genetic risk for AD, and use transgenic models, and iPSC-based human models of the BBB and brain on a chip to understand how genes that carry risk for sporadic AD (e.g., APOE4, PICALM) affect the cerebrovascular system contributing to dementia, and AD disease onset and progression.
    • We are developing cell and gene therapy approaches for AD using i) iPSC-derived human pericytes that express different protective target genes, and/or ii) BBB cell-specific gene delivery to influence neuronal and synaptic functions.
    • We study APC biologics and mimetic peptides for white matter stroke, AD and ALS.
    • We work on identifying small molecules that influence genes/pathways linked to AD.
    • We work on CSF and imaging BBB biomarkers of human cognitive dysfunction.
    • Recently, we have initiated studies to understand how gut microbiome influences BBB in relation to neuronal and synaptic functions using transgenic and human iPSC models.
    • We initiated program on BBB molecular signatures (snRNAseq, proteome) in health and disease using transgenic and human models, and human tissue studies.

    Zlokovic is recognized internationally as a leader in the fields of AD and stroke research. Thomson Reuters and Clarivate Analytics listed Zlokovic as one of “The World’s Most Influential Scientific Minds” for 17 consecutive years (2002-2019) for ranking in 1 % of the most-cited authors in the field of neurosciences and behavioral sciences. He received MetLife Award for Medical Research for “significant contributions to our understanding of Alzheimer’s disease and for bringing us closer to a cure”, Potamkin Prize from the American Academy of Neurology " in recognition of outstanding achievements in research on Alzheimer’s and related neurodegenerative diseases”, Javits Award from NINDS "in recognition of distinguished record of substantial contributions in a field of neurological sciences”, and MERIT Award from NIA "in recognition of sustained contribution to aging and leadership and commitment to the field”. He is a fellow of the AAAS, The European Academy of Sciences, and The Dana Alliance for Brain Initiative. In 2017, 2018 and 2019, he was asked by the Nobel Assembly at Karolinska Institutet, The Nobel Committee to nominate one or more candidates for the Nobel Prize in Physiology and Medicine. He is also an active entrepreneur and inventor. He co-founded ZZ Biotech, a biotechnology company that is developing treatments for stroke and neurological disorders. 

    Featured Publications representing interests of the Zlokovic laboratory:

    i-10 index: 241; h-index: 98; 41,208 citations (Google Scholar, Sep 2019); complete list in Google Scholar: https://goo.gl/2Npcj2
    Nation DA, Sweeney MD, Montagne A, Sagare AP, D’Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel D, Liu CY, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV (2019) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nature Medicine 25, 270-276.

    Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV (2019) Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nature Neuroscience 22, 1089–1098.

    Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV (2019) Blood-Brain Barrier: From Physiology to Disease and Back. Physiological Reviews 99, 21-78.

    Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV (2019) 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. Journal of Experimental Medicine 216(2), 279-293.

    Lyden P, Pryor KE, Coffey CS, Cudkowicz M, …Davis TP, Toga AW, Griffin JH, Zlokovic BV, NeuroNEXT Clinical Trials Network NN104 Investigators. (2019) Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Annals of Neurology 85(1), 125-136.

    Sweeney MD, Kisler K, Montagne A, Toga A, Zlokovic BV (2018) The role of brain vasculature in neurodegenerative disorders. Nature Neuroscience 21(10), 1318-1331

    Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV (2018) Pericyte degeneration causes white matter dysfunction in the mouse CNS. Nature Medicine 24(3), 326-337. 

    Sweeney MD, Sagare AP, Zlokovic BV (2018) Blood-brain barrier breakdown in Alzheimer’s disease and other neurodegenerative disorders. Nature Reviews Neurology 14(3), 133-150. 

    Kisler K, Lazic D, Sweeney M, Plunkett S, Khatib ME, Vinogradov SA, Boas DA, Sakadzic S, Zlokovic BV (2018) Diverse protocols for in vivo measurements of cerebrovascular hemodynamic responses and tissue oxygen levels and delivery in the mouse brain. Nature Protocols 13(6), 1377-1402. 

    Sweeney MD, Zlokovic BV (2018) A lymphatic waste-disposal system implicated in Alzheimer’s disease. Nature 560 (7717) 172-174.

    Kisler K, Nelson A, Montagne A, Zlokovic BV (2017) Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer’s disease. Nature Reviews Neuroscience 18, 419-434. 

    Kisler K, Nelson AR, Rege SV, Ramanathan A, Wang Y, Ahuja A, Lazic D, Tsai PS, Zhao Z, Zhou Y, Boas DA, Sakadžic S, Zlokovic BV (2017) Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain. Nature Neuroscience 20, 406-416. 

    Wang Y, Zhao Z, Rege S, Griffin JH, Goldman SA, Zlokovic BV (2016) 3K3A-APC stimulates post-ischemic neuronal repair by human neural progenitor cells in mice. Nature Medicine 22 (9): 1050-1055.

    Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nature Neuroscience 19 (6): 771-783.

    Zhao Z, Nelson A, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of blood-brain barrier. Cell 163, Nov 19;163(5):1064-78. 

    Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NQ, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV (2015) Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance. Nature Neuroscience 18, 978-987.

    Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV (2015) GLUT1 reductions exacerbate Alzheimer’s disease vasculo-neuronal dysfunction and degeneration. Nature Neuroscience 18, 521-530.

    Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.

    Griffin JH, Zlokovic BV, Mosnier LO (2015) Activated Protein C: Biased for Translation. Blood 125 (19), 2898-2907.

    Zhao Z and Zlokovic BV (2014) Blood-Brain Barrier: A Dual Life of MFSD2A? Neuron 82, 728–730.

    Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong G, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV (2014) Blood-spinal cord barrier disruption contributes to early motor neuron degeneration in ALS model mice. Proceedings of the National Academy of Sciences USA 111(11), E1035-42.

    Bell RD, Winkler E, Sagare A, Singh I, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk B, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.

    Deane R, Singh I, Sagare A, Bell R, Ross NT, Larue B, Love R, Perry S, Deane RJ, Thiyagarajan M, Zarcone T, Friedman A, Miller BL, Zlokovic BV (2012) A novel multi-modal RAGE-specific inhibitor controls amyloid-beta-mediated brain disorder in mice. Journal of Clinical Investigation 122 (4), 1377-1392.

    Winkler E, Bell R, Zlokovic BV (2011) Functions of CNS pericytes in health and disease. Nature Neuroscience 14, 1398-1405.

    Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders. Nature Reviews Neuroscience 12, 723-738.

    Winkler EA, Bell RD, Zlokovic BV (2011) Lack of Smad and Notch Leads to a Fatal Game of Brain Pericyte Hopscotch. Developmental Cell (Cell) 20 (3), 279-281.

    Zlokovic BV, Griffin JH (2011) Activated protein C cytoprotective pathways and implications for stroke and neurological disorders. Trends in Neurosciences 34 (4), 1198-2009.

    Zlokovic BV (2010) Neurodegeneration and the neurovascular unit. Nature Medicine 16(12), 1370-71.

    Bell RD, Winkler EA, Sagare A, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and the neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427.

    Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV (2010) Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood 115, 4963-4972.

    Bell RD , Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JP, Zlokovic BV (2009) SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nature Cell Biology 11(2), 143-153.

    Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino F, Stojanovic K, Cleveland DW, Zlokovic BV (2009) Activated protein C slows ALS-like disease by transcrptionally inhibiting SOD1 in motor neurons and microglial cells. Journal of Clinical Investigation 119(11), 3437-3440.

    Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV (2008) Apolipoprotein E isoform-specific disruption of Alzheimer’s amyloid ?-peptide clearance from mouse brain Journal of Clinical Investigation 118(12), 4002-4013.

    Zhong Z, Deane R, Zarina A, Parisi M, Shapovalov Y, 0’Banion K, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nature Neuroscience 11(4), 420-422.

    Zlokovic BV (2008) Blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57, 178-201.

    Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Pelmutter D, Coma M, Zhong Z, Zlokovic BV (2007) Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine 13 (9), 1029-1031.

    Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV (2007). Serum response factor and myocardin mediate cerebral arterial hypercontractility and blood flow dysregulation in Alzheimer’s phenotype. Proceedings of the National Academy of Sciences USA 104, 823-828.

    Mosnier L, Zlokovic BV, Griffin JH (2007) The cellular protein C pathway. Blood 109(8), 161-172.

    Cheng T, Petraglia A, Li Z, Meedakshisudaram T, Wu Z, Zhong Z, Liu D, Maggirwar SB, Deane R, Fernandez J, LaRue B, Griffin J, Chopp M, Zlokovic BV (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nature Medicine 12 (11), 1278-1285.

    Zlokovic BV (2006) Remodeling after stroke. Nature Medicine 12 (4) 390-391.

    Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks A, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetski R, Song H, Hofman F, Zlokovic BV (2005) Role of MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nature Medicine 11(9), 959-965.

    Zlokovic BV (2005) Neurovascular mechanisms of Alzheimer’s neurodegeneration. Trends in Neurosciences 28, 202-208.

    Deane R, Wu Z, Davis J, Yan SD, Hamm K, Sagare A, Xu F, Spijkers P, Lenting PJ, Van Nostrand WE, Zlokovic BV (2004) LRP-amyloid-beta interaction mediates differential brain efflux of Abeta isoforms Neuron 43, 33-44.

    Liu D, Cheng T, Guo H, Fernandez AJ, Griffin JH, Song X, Zlokovic BV (2004) Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C. Nature Medicine 10, (12), 1379-1383.

    Guo H, Liu D, Gelbard H, Cheng T, Fernandez JA, Insalaca R, Griffin JH, Zlokovic BV (2004) Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron 41, 563-572.

    Deane R, Yan SD, Kumar R, Jovanovic S, LaRue B, Welch D, Maness L, Yu J, Zhu H, Ghiso J, Frangione B, Schmidt AM, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic BV (2003) RAGE mediates amyloid-ß peptide transport across the blood-brain barrier and accumulation in brain. Nature Medicine 9(7), 907-913.

    Cheng T, Liu D, Fernández JA, Griffin JH, Castellino F, Rosen E, Fukudome K, Zlokovic BV (2003) Activated protein C blocks P53-mediated apoptosis in ischemic human brain endothelium and is neuroportective. Nature Medicine 9, 338-342.

    Domotor E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV (2003) Activated protein C alters cytosolic Ca2+ flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease-activated receptor-1. Blood 101, 4797-4801.

    Shibata M, Subramanyan RK, Amar A, Fernandez J, Griffin J, Zlokovic BV (2001) Anti-inflammatory, antithrombotic and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke with cerebrovascular thrombosis. Circulation 103, 1799-1805.

    Shibata M, Yamada S, Kumar RS, Calero M, Bading B, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV (2000) Clearance of Alzheimer’s amyloid-ß1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. Journal of Clinical Investigation 106(12), 1489-1499.

    Zlokovic BV, Shinya Y, Holtzman D, Ghiso J, Frangione B (2000) Clearance of amyloid ß-peptide from brain: transport or metabolism? Nature Medicine 6, 718-719.

    Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV (1998) Human blood-brain barrier receptors for Alzheimer's amyloid-? 1-40: Asymmetrical binding, endocytosis and transcytosis at the apical side of brain microvascular endothelial cell monolayer. Journal of Clinical Investigation 102, 734-743.

    Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J (1996) Glycoprotein 330/megalin: Porbable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer's Disease amyloid-? at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences USA 93, 4229-4236.

    Collapse Research 
    Collapse Research Activities and Funding
    Interaction of the microbiome with the blood-brain barrier
    Open Philanthropy Nov 1, 2018 - Oct 31, 2022
    Role: Principal Investigator
    The role of PICALM mutations in Alzheimer’s disease
    Cure Alzheimer's Fund Dec 27, 2017 - Dec 28, 2019
    Role: Principal Investigator
    Vascular Contributions To Dementia and Amyloid and Tau Lesions in APOE4
    Alzheimer's Association Sep 30, 2017 - Aug 30, 2022
    Role: Principal Investigator
    Understanding the role of the perivascular space in cerebral small vessel disease
    Fondation Leducq Jan 1, 2017 - Jan 1, 2022
    Role: North American Coordinator
    The role of pericytes in white matter disease
    NIH/NINDS R01NS100459Sep 30, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease
    NIH/NIA P01AG052350Sep 30, 2016 - May 31, 2021
    Role: Principal Investigator
    Activated protein C system in stroke models
    NIH/NINDS R01NS090904Sep 30, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Caloric restriction and Alzheimers ABeta clearance pathway
    NIH/NIA R03AG046216Aug 15, 2013 - Jul 31, 2016
    Role: Principal Investigator
    The role of PICALM in vascular clearance of amyloid-b
    Cure Alzheimer's Fund Sep 1, 2012 - Nov 30, 2019
    Role: Principal Investigator
    The role of pericytes in the aging brain and pathogenesis and treatment of neurodegeneration, and Alzheimer's A-beta and tau pathology
    NIH/NIA R01AG039452Aug 1, 2011 - Nov 30, 2023
    Role: Principal Investigator
    Protein S: Neurovascular Protection in Stroke
    NIH/NHLBI R01HL081528Jul 1, 2006 - Jun 30, 2011
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH/NIA R01AG023084Dec 1, 2003 - Mar 31, 2020
    Role: Principal Investigator
    Cerebrovascular beta-Amyloidosis: A-beta CNS Transport Pathways
    NIH/NIA R37AG023084Dec 1, 2003 - Aug 31, 2014
    Role: Principal Investigator
    Regulation of Brain Thrombosis in Stroke Models
    NIH/NHLBI R01HL063290Jul 15, 1999 - Apr 30, 2014
    Role: Principal Investigator
    AGING BRAIN--CEREBROVASCULAR MECHANISM &AMYLOID BETA
    NIH/NIA P01AG016223May 1, 1999 - Apr 30, 2004
    Role: Principal Investigator
    AGING AND BLOOD BRAIN BARRIER AB TRASPORT IN PRIMATES
    NIH/NIA R03AG014526Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
    Alzheimer's Abeta, apolipoproteins and blood-brain barrier
    NIH/NINDS R01NS034467Sep 1, 1995 - Mar 31, 2019
    Role: Principal Investigator
    Alzheimer's Abeta, apolipoproteins and blood-brain barrier
    NIH/NINDS R37NS034467Sep 1, 1995 - Mar 31, 2014
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH/NEI R01EY009399Aug 1, 1993 - Jul 31, 1996
    Role: Principal Investigator
    BLOOD-LENS TRANSFER OF GLUTATHIONE &SULFUR AMINO ACIDS
    NIH/NEI R55EY009399Sep 30, 1992 - Jul 31, 1993
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Montagne A, Huuskonen MT, Rajagopal G, Sweeney MD, Nation DA, Sepehrband F, D'Orazio LM, Harrington MG, Chui HC, Law M, Toga AW, Zlokovic BV. Undetectable gadolinium brain retention in individuals with an age-dependent blood-brain barrier breakdown in the hippocampus and mild cognitive impairment. Alzheimers Dement. 2019 Dec; 15(12):1568-1575. PMID: 31862169.
      View in: PubMed
    2. Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-a in APOE4 carriers. Neurobiol Aging. 2019 Nov 05. PMID: 31870643.
      View in: PubMed
    3. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Int J Stroke. 2019 Sep 22; 1747493019871915. PMID: 31543058.
      View in: PubMed
    4. Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 Oct 03; 25(4):486-500.e9. PMID: 31523028.
      View in: PubMed
    5. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. PMID: 31310593.
      View in: PubMed
    6. Hachinski V, Einhäupl K, Ganten D, Alladi S, Brayne C, Stephan BCM, Sweeney MD, Zlokovic B, Iturria-Medina Y, Iadecola C, Nishimura N, Schaffer CB, Whitehead SN, Black SE, Østergaard L, Wardlaw J, Greenberg S, Friberg L, Norrving B, Rowe B, Joanette Y, Hacke W, Kuller L, Dichgans M, Endres M, Khachaturian ZS. Preventing dementia by preventing stroke: The Berlin Manifesto. Alzheimers Dement. 2019 Jul; 15(7):961-984. PMID: 31327392.
      View in: PubMed
    7. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. PMID: 31235908.
      View in: PubMed
    8. Methner C, Mishra A, Golgotiu K, Li Y, Wei W, Yanez ND, Zlokovic B, Wang RK, Alkayed NJ, Kaul S, Iliff JJ. Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis. Am J Physiol Heart Circ Physiol. 2019 Aug 01; 317(2):H255-H263. PMID: 31125259.
      View in: PubMed
    9. Jovic M, Loncarevic-Vasiljkovic N, Ivkovic S, Dinic J, Milanovic D, Zlokovic B, Kanazir S. Short-term fish oil supplementation applied in presymptomatic stage of Alzheimer's disease enhances microglial/macrophage barrier and prevents neuritic dystrophy in parietal cortex of 5xFAD mouse model. PLoS One. 2019; 14(5):e0216726. PMID: 31095617.
      View in: PubMed
    10. Zeng J, Wang Y, Luo Z, Chang LC, Yoo JS, Yan H, Choi Y, Xie X, Deverman BE, Gradinaru V, Gupton SL, Zlokovic BV, Zhao Z, Jung JU. TRIM9-Mediated Resolution of Neuroinflammation Confers Neuroprotection upon Ischemic Stroke in Mice. Cell Rep. 2019 Apr 09; 27(2):549-560.e6. PMID: 30970257.
      View in: PubMed
    11. Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. Prion Protein Antagonists Rescue Alzheimer's Amyloid-ß-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76. PMID: 30661727.
      View in: PubMed
    12. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. PMID: 30647119.
      View in: PubMed
    13. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. PMID: 30643288.
      View in: PubMed
    14. Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV. Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke. Ann Neurol. 2019 01; 85(1):125-136. PMID: 30450637.
      View in: PubMed
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    112. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. PMID: 20043896.
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    122. Thiyagarajan M, Fernández JA, Lane SM, Griffin JH, Zlokovic BV. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci. 2008 Nov 26; 28(48):12788-97. PMID: 19036971.
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    123. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. PMID: 19033669.
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    126. Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10. PMID: 18451334.
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    127. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. PMID: 18344992.
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    131. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. PMID: 17694066.
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    135. Chow N, Bell RD, Deane R, Streb JW, Chen J, Brooks A, Van Nostrand W, Miano JM, Zlokovic BV. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):823-8. PMID: 17215356.
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    136. Mosnier LO, Zlokovic BV, Griffin JH. The cytoprotective protein C pathway. Blood. 2007 Apr 15; 109(8):3161-72. PMID: 17110453.
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    139. Zlokovic BV. Remodeling after stroke. Nat Med. 2006 Apr; 12(4):390-1. PMID: 16598283.
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    141. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. PMID: 16354907.
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    142. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. PMID: 16239972.
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    144. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. PMID: 16116430.
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    145. Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005 Apr; 28(4):202-8. PMID: 15808355.
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    146. Giri RK, Rajagopal V, Shahi S, Zlokovic BV, Kalra VK. Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1. Am J Physiol Cell Physiol. 2005 Aug; 289(2):C264-76. PMID: 15743889.
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    149. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. PMID: 15325132.
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    150. Deane R, Wu Z, Zlokovic BV. RAGE (yin) versus LRP (yang) balance regulates alzheimer amyloid beta-peptide clearance through transport across the blood-brain barrier. Stroke. 2004 Nov; 35(11 Suppl 1):2628-31. PMID: 15459432.
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    151. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. PMID: 15294142.
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    152. Filbrandt CR, Wu Z, Zlokovic B, Opanashuk L, Gasiewicz TA. Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes. Neurotoxicology. 2004 Jun; 25(4):605-16. PMID: 15183014.
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    153. Zlokovic BV. Clearing amyloid through the blood-brain barrier. J Neurochem. 2004 May; 89(4):807-11. PMID: 15140180.
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    155. Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem. 2004 May 07; 279(19):20296-306. PMID: 14985348.
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    156. Guo H, Liu D, Gelbard H, Cheng T, Insalaco R, Fernández JA, Griffin JH, Zlokovic BV. Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3. Neuron. 2004 Feb 19; 41(4):563-72. PMID: 14980205.
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    157. Deane R, Zheng W, Zlokovic BV. Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain. J Neurochem. 2004 Feb; 88(4):813-20. PMID: 14756801.
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    158. Wu Z, Hofman FM, Zlokovic BV. A simple method for isolation and characterization of mouse brain microvascular endothelial cells. J Neurosci Methods. 2003 Nov 30; 130(1):53-63. PMID: 14583404.
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    159. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003 Jul; 9(7):907-13. PMID: 12808450.
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    160. Fernández JA, Xu X, Liu D, Zlokovic BV, Griffin JH. Recombinant murine-activated protein C is neuroprotective in a murine ischemic stroke model. Blood Cells Mol Dis. 2003 May-Jun; 30(3):271-6. PMID: 12737945.
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    161. Liu D, Guo H, Griffin JH, Fernández JA, Zlokovic BV. Protein S confers neuronal protection during ischemic/hypoxic injury in mice. Circulation. 2003 Apr 08; 107(13):1791-6. PMID: 12665496.
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    162. Dömötör E, Benzakour O, Griffin JH, Yule D, Fukudome K, Zlokovic BV. Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1. Blood. 2003 Jun 15; 101(12):4797-801. PMID: 12586611.
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    163. Cheng T, Liu D, Griffin JH, Fernández JA, Castellino F, Rosen ED, Fukudome K, Zlokovic BV. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat Med. 2003 Mar; 9(3):338-42. PMID: 12563316.
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    164. Amar AP, Zlokovic BV, Apuzzo ML. Endovascular restorative neurosurgery: a novel concept for molecular and cellular therapy of the nervous system. Neurosurgery. 2003 Feb; 52(2):402-12; discussion 412-3. PMID: 12535371.
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    165. Zlokovic BV. Current treatments and therapeutic targets in Alzheimer's disease. Adv Drug Deliv Rev. 2002 Dec 07; 54(12):1533-7. PMID: 12453670.
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    167. Giri R, Selvaraj S, Miller CA, Hofman F, Yan SD, Stern D, Zlokovic BV, Kalra VK. Effect of endothelial cell polarity on beta-amyloid-induced migration of monocytes across normal and AD endothelium. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C895-904. PMID: 12176746.
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    168. Griffin JH, Zlokovic B, Fernández JA. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol. 2002 Jul; 39(3):197-205. PMID: 12124682.
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    169. Mackic JB, Bading J, Ghiso J, Walker L, Wisniewski T, Frangione B, Zlokovic BV. Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions. Vascul Pharmacol. 2002 Jun; 38(6):303-13. PMID: 12529925.
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    170. Bading JR, Yamada S, Mackic JB, Kirkman L, Miller C, Calero M, Ghiso J, Frangione B, Zlokovic BV. Brain clearance of Alzheimer's amyloid-beta40 in the squirrel monkey: a SPECT study in a primate model of cerebral amyloid angiopathy. J Drug Target. 2002 Jun; 10(4):359-68. PMID: 12164385.
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    171. Grammas P, Yamada M, Zlokovic B. The cerebromicrovasculature: a key player in the pathogenesis of Alzheimer's disease. J Alzheimers Dis. 2002 Jun; 4(3):217-23. PMID: 12226540.
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    172. Monro OR, Mackic JB, Yamada S, Segal MB, Ghiso J, Maurer C, Calero M, Frangione B, Zlokovic BV. Substitution at codon 22 reduces clearance of Alzheimer's amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood. Neurobiol Aging. 2002 May-Jun; 23(3):405-12. PMID: 11959403.
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    173. Chen P, Shibata M, Zidovetzki R, Fisher M, Zlokovic BV, Hofman FM. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J Neuroimmunol. 2001 May 01; 116(1):62-73. PMID: 11311331.
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    174. Zlokovic BV, Cox C. Lower cognitive performance of older football players possessing apolipoprotein E epsilon4. Neurosurgery. 2001 May; 48(5):1196-7. PMID: 11334298.
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    175. Shibata M, Kumar SR, Amar A, Fernandez JA, Hofman F, Griffin JH, Zlokovic BV. Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke. Circulation. 2001 Apr 03; 103(13):1799-805. PMID: 11282913.
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    176. MacDonald TJ, Taga T, Shimada H, Tabrizi P, Zlokovic BV, Cheresh DA, Laug WE. Preferential susceptibility of brain tumors to the antiangiogenic effects of an alpha(v) integrin antagonist. Neurosurgery. 2001 Jan; 48(1):151-7. PMID: 11152340.
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    177. Giri R, Shen Y, Stins M, Du Yan S, Schmidt AM, Stern D, Kim KS, Zlokovic B, Kalra VK. beta-amyloid-induced migration of monocytes across human brain endothelial cells involves RAGE and PECAM-1. Am J Physiol Cell Physiol. 2000 Dec; 279(6):C1772-81. PMID: 11078691.
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    178. Shibata M, Yamada S, Kumar SR, Calero M, Bading J, Frangione B, Holtzman DM, Miller CA, Strickland DK, Ghiso J, Zlokovic BV. Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest. 2000 Dec; 106(12):1489-99. PMID: 11120756.
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    179. Calero M, Rostagno A, Matsubara E, Zlokovic B, Frangione B, Ghiso J. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech. 2000 Aug 15; 50(4):305-15. PMID: 10936885.
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    180. Yan SD, Roher A, Chaney M, Zlokovic B, Schmidt AM, Stern D. Cellular cofactors potentiating induction of stress and cytotoxicity by amyloid beta-peptide. Biochim Biophys Acta. 2000 Jul 26; 1502(1):145-57. PMID: 10899440.
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    182. Tokuda T, Calero M, Matsubara E, Vidal R, Kumar A, Permanne B, Zlokovic B, Smith JD, Ladu MJ, Rostagno A, Frangione B, Ghiso J. Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides. Biochem J. 2000 Jun 01; 348 Pt 2:359-65. PMID: 10816430.
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    183. Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV. Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab. 2000 Jun; 20(6):998-1009. PMID: 10894183.
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    184. Zlokovic BV, Jovanovic S, Miao W, Samara S, Verma S, Farrell CL. Differential regulation of leptin transport by the choroid plexus and blood-brain barrier and high affinity transport systems for entry into hypothalamus and across the blood-cerebrospinal fluid barrier. Endocrinology. 2000 Apr; 141(4):1434-41. PMID: 10746647.
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    185. Calero M, Tokuda T, Rostagno A, Kumar A, Zlokovic B, Frangione B, Ghiso J. Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J. 1999 Dec 01; 344 Pt 2:375-83. PMID: 10567218.
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    186. Tabrizi P, Wang L, Seeds N, McComb JG, Yamada S, Griffin JH, Carmeliet P, Weiss MH, Zlokovic BV. Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background. Arterioscler Thromb Vasc Biol. 1999 Nov; 19(11):2801-6. PMID: 10559029.
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    187. Yu H, Wang Y, Eton D, Stins M, Wang L, Apuzzo ML, Weaver FA, McComb JG, Weiss MH, Zlokovic BV. Retroviral vector-mediated transfer and expression of human tissue plasminogen activator cDNA in bovine brain endothelial cells. Neurosurgery. 1999 Oct; 45(4):962-8; discussion 968-70. PMID: 10515502.
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    188. Imai F, Sawada M, Suzuki H, Zlokovic BV, Kojima J, Kuno S, Nagatsu T, Nitatori T, Uchiyama Y, Kanno T. Exogenous microglia enter the brain and migrate into ischaemic hippocampal lesions. Neurosci Lett. 1999 Sep 10; 272(2):127-30. PMID: 10507558.
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    189. Mackic JB, Stins M, Jovanovic S, Kim KS, Bartus RT, Zlokovic BV. Cereport (RMP-7) increases the permeability of human brain microvascular endothelial cell monolayers. Pharm Res. 1999 Sep; 16(9):1360-5. PMID: 10496650.
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    190. Kannan R, Mackic JB, Zlokovic BV. Corneal transport of circulating glutathione in normal and galactosemic guinea pigs. Cornea. 1999 May; 18(3):321-7. PMID: 10336036.
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    191. Chun JT, Wang L, Pasinetti GM, Finch CE, Zlokovic BV. Glycoprotein 330/megalin (LRP-2) has low prevalence as mRNA and protein in brain microvessels and choroid plexus. Exp Neurol. 1999 May; 157(1):194-201. PMID: 10222122.
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    192. Wang L, Tran ND, Schreiber SS, Fisher M, Zlokovic BV. Rat brain capillary thrombomodulin: structure and function. Thromb Res. 1998 Dec 01; 92(5):213-9. PMID: 9851812.
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    193. MacDonald TJ, Tabrizi P, Shimada H, Zlokovic BV, Laug WE. Detection of brain tumor invasion and micrometastasis in vivo by expression of enhanced green fluorescent protein. Neurosurgery. 1998 Dec; 43(6):1437-42; discussion 1442-3. PMID: 9848858.
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    194. Schreiber SS, Tan Z, Sun N, Wang L, Zlokovic BV. Immunohistochemical localization of tissue plasminogen activator in vascular endothelium of stroke-prone regions of the rat brain. Neurosurgery. 1998 Oct; 43(4):909-13. PMID: 9766319.
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    195. Zlokovic BV, Apuzzo ML. Strategies to circumvent vascular barriers of the central nervous system. Neurosurgery. 1998 Oct; 43(4):877-8. PMID: 9766315.
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    196. Tran ND, Wang L, Schreiber SS, Zlokovic B, Fisher M. Measurement of thrombomodulin mRNA expression in brain capillaries by polymerase chain reaction. Thromb Res. 1998 Aug 15; 91(4):191-7. PMID: 9736422.
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    197. Mackic JB, Stins M, McComb JG, Calero M, Ghiso J, Kim KS, Yan SD, Stern D, Schmidt AM, Frangione B, Zlokovic BV. Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer. J Clin Invest. 1998 Aug 15; 102(4):734-43. PMID: 9710442.
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    198. LeMay DR, Kittaka M, Gordon EM, Gray B, Stins MF, McComb JG, Jovanovic S, Tabrizi P, Weiss MH, Bartus R, Anderson WF, Zlokovic BV. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy. Hum Gene Ther. 1998 May 01; 9(7):989-95. PMID: 9607410.
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    199. Mackic JB, Weiss MH, Miao W, Kirkman E, Ghiso J, Calero M, Bading J, Frangione B, Zlokovic BV. Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer's amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy. J Neurochem. 1998 Jan; 70(1):210-5. PMID: 9422364.
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    200. Lavine SD, Hofman FM, Zlokovic BV. Circulating antibody against tumor necrosis factor-alpha protects rat brain from reperfusion injury. J Cereb Blood Flow Metab. 1998 Jan; 18(1):52-8. PMID: 9428305.
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    201. Kittaka M, Giannotta SL, Zelman V, Correale JD, DeGiorgio CM, Weiss MH, Zlokovic BV. Attenuation of brain injury and reduction of neuron-specific enolase by nicardipine in systemic circulation following focal ischemia and reperfusion in a rat model. J Neurosurg. 1997 Nov; 87(5):731-7. PMID: 9347982.
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    202. Wang L, Tran ND, Kittaka M, Fisher MJ, Schreiber SS, Zlokovic BV. Thrombomodulin expression in bovine brain capillaries. Anticoagulant function of the blood-brain barrier, regional differences, and regulatory mechanisms. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):3139-46. PMID: 9409303.
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    203. Martel CL, Mackic JB, Matsubara E, Governale S, Miguel C, Miao W, McComb JG, Frangione B, Ghiso J, Zlokovic BV. Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta. J Neurochem. 1997 Nov; 69(5):1995-2004. PMID: 9349544.
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    204. Zlokovic BV. Antithrombotic, procoagulant, and fibrinolytic mechanisms in cerebral circulation: implications for brain injury and protection. Neurosurg Focus. 1997 Jun 15; 2(6):e5. PMID: 15099052.
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    205. Mackic JB, Kannan R, Kaplowitz N, Zlokovic BV. Low de novo glutathione synthesis from circulating sulfur amino acids in the lens epithelium. Exp Eye Res. 1997 Apr; 64(4):615-26. PMID: 9227280.
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    206. Zlokovic BV, Apuzzo ML. Cellular and molecular neurosurgery: pathways from concept to reality--part I: target disorders and concept approaches to gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):789-803; discussion 803-4. PMID: 9092853.
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    207. Zlokovic BV, Apuzzo ML. Cellular and molecular neurosurgery: pathways from concept to reality--part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery. 1997 Apr; 40(4):805-12; discussion 812-3. PMID: 9092854.
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    208. Kannan R, Fernández-Checa JC, García-Ruiz C, Mackic JB, Zlokovic BV. Liver and lens glutathione and cysteine regulation in galactose-fed guinea pigs. Curr Eye Res. 1997 Apr; 16(4):365-71. PMID: 9134326.
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    209. Wang L, Kittaka M, Sun N, Schreiber SS, Zlokovic BV. Chronic nicotine treatment enhances focal ischemic brain injury and depletes free pool of brain microvascular tissue plasminogen activator in rats. J Cereb Blood Flow Metab. 1997 Feb; 17(2):136-46. PMID: 9040492.
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    210. Elliot PJ, Bartus RT, Mackic JB, Zlokovic BV. Intravenous infusion of RMP-7 increases ocular uptake of ganciclovir. Pharm Res. 1997 Jan; 14(1):80-5. PMID: 9034225.
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    211. Zlokovic B. Can blood-brain barrier play a role in the development of cerebral amyloidosis and Alzheimer's disease pathology. Neurobiol Dis. 1997; 4(1):23-6. PMID: 9258908.
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    212. Kannan R, Yi JR, Tang D, Zlokovic BV, Kaplowitz N. Identification of a novel, sodium-dependent, reduced glutathione transporter in the rat lens epithelium. Invest Ophthalmol Vis Sci. 1996 Oct; 37(11):2269-75. PMID: 8843923.
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    213. Zlokovic BV, Martel CL, Matsubara E, McComb JG, Zheng G, McCluskey RT, Frangione B, Ghiso J. Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4229-34. PMID: 8633046.
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    214. Kannan R, Yi JR, Tang D, Li Y, Zlokovic BV, Kaplowitz N. Evidence for the existence of a sodium-dependent glutathione (GSH) transporter. Expression of bovine brain capillary mRNA and size fractions in Xenopus laevis oocytes and dissociation from gamma-glutamyltranspeptidase and facilitative GSH transporters. J Biol Chem. 1996 Apr 19; 271(16):9754-8. PMID: 8621654.
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    215. Kittaka M, Wang L, Sun N, Schreiber SS, Seeds NW, Fisher M, Zlokovic BV. Brain capillary tissue plasminogen activator in a diabetes stroke model. Stroke. 1996 Apr; 27(4):712-9. PMID: 8614937.
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    216. Martel CL, Mackic JB, McComb JG, Ghiso J, Zlokovic BV. Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer's amyloid beta in guinea pigs. Neurosci Lett. 1996 Mar 15; 206(2-3):157-60. PMID: 8710175.
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    217. Martel CL, Mackic JB, Adams JD, McComb JG, Weiss MH, Zlokovic BV. Transport of dopamine at the blood-brain barrier of the guinea pig: inhibition by psychotropic drugs and nicotine. Pharm Res. 1996 Feb; 13(2):290-5. PMID: 8932451.
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    218. Chen TC, Mackic JB, McComb JG, Giannotta SL, Weiss MH, Zlokovic BV. Cellular uptake and transport of methylprednisolone at the blood-brain barrier. Neurosurgery. 1996 Feb; 38(2):348-54. PMID: 8869063.
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    219. Mackic JB, Jinagouda S, McComb JG, Weiss MH, Kannan R, Kaplowitz N, Zlokovic BV. Transport of circulating reduced glutathione at the basolateral side of the anterior lens epithelium: physiologic importance and manipulations. Exp Eye Res. 1996 Jan; 62(1):29-37. PMID: 8674510.
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    220. Zlokovic BV. Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier. Life Sci. 1996; 59(18):1483-97. PMID: 8890929.
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    221. Zlokovic BV, Wang L, Sun N, Haffke S, Verrall S, Seeds NW, Fisher MJ, Schreiber SS. Expression of tissue plasminogen activator in cerebral capillaries: possible fibrinolytic function of the blood-brain barrier. Neurosurgery. 1995 Nov; 37(5):955-61. PMID: 8559345.
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    222. Elliott PJ, Mackic JB, Graney WF, Bartus RT, Zlokovic BV. RMP-7, a bradykinin agonist, increases permeability of blood-ocular barriers in the guinea pig. Invest Ophthalmol Vis Sci. 1995 Nov; 36(12):2542-7. PMID: 7591644.
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    223. Zlokovic BV. Cerebrovascular permeability to peptides: manipulations of transport systems at the blood-brain barrier. Pharm Res. 1995 Oct; 12(10):1395-406. PMID: 8584471.
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    224. Kannan R, Yi JR, Zlokovic BV, Kaplowitz N. Molecular characterization of a reduced glutathione transporter in the lens. Invest Ophthalmol Vis Sci. 1995 Aug; 36(9):1785-92. PMID: 7635653.
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    225. Redzic ZB, Markovic ID, Jovanovic SS, Mitrovic DM, Zlokovic BV, Rakic LM. Slow penetration of [3H] tiazofurin into guinea pig brain by a saturable mechanism. Methods Find Exp Clin Pharmacol. 1995 Jul-Aug; 17(6):407-14. PMID: 8642902.
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    226. Redzic ZB, Markovic ID, Jovanovic SS, Zlokovic BV, Rakic LM. Penetration of [3H] tiazofurin into guinea pig eye by a saturable mechanism. Eur J Ophthalmol. 1995 Apr-Jun; 5(2):131-5. PMID: 7549442.
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    227. Zlokovic BV, Martel CL, Mackic JB, Matsubara E, Wisniewski T, McComb JG, Frangione B, Ghiso J. Brain uptake of circulating apolipoproteins J and E complexed to Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1431-7. PMID: 7802679.
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    228. Zlokovic BV, Mackic JB, McComb JG, Kaplowitz N, Weiss MH, Kannan R. Blood-to-lens transport of reduced glutathione in an in situ perfused guinea-pig eye. Exp Eye Res. 1994 Oct; 59(4):487-96. PMID: 7859824.
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    229. Zlokovic BV, Mackic JB, McComb JG, Weiss MH, Kaplowitz N, Kannan R. Evidence for transcapillary transport of reduced glutathione in vascular perfused guinea-pig brain. Biochem Biophys Res Commun. 1994 May 30; 201(1):402-8. PMID: 8198602.
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    230. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. PMID: 8147886.
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    231. Mackic JB, Ross-Cisneros FN, McComb JG, Bekhor I, Weiss MH, Kannan R, Zlokovic BV. Galactose-induced cataract formation in guinea pigs: morphologic changes and accumulation of galactitol. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):804-10. PMID: 8125742.
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    232. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, Frangione B. Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun. 1993 Dec 30; 197(3):1034-40. PMID: 8280117.
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    233. Zlokovic BV. The blood-brain barrier in vitro: recent progress. Neurochem Int. 1993 Dec; 23(6):523. PMID: 8281120.
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    234. Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25. PMID: 8385133.
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    235. Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 1993 Mar-Apr; 34(2):211-9. PMID: 8384107.
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    236. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Dunlop DS, Jacobson AE, Rice KC, de Costa B, Reith ME. Metaphit-induced audiogenic seizures in mice: I. Pharmacologic characterization. Epilepsia. 1993 Mar-Apr; 34(2):201-10. PMID: 8384106.
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    237. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. PMID: 8392783.
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    238. Kannan R, Tang D, Mackic JB, Zlokovic BV, Fernandez-Checa JC. A simple technique to determine glutathione (GSH) levels and synthesis in ocular tissues as GSH-bimane adduct: application to normal and galactosemic guinea-pigs. Exp Eye Res. 1993 Jan; 56(1):45-50. PMID: 8432334.
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    239. Zlokovic BV, McComb JG, Lipovac MN, Chen TC, Mackic JB, Schneider J, Gianotta SL, Weiss MH. Differential brain penetration of cerebroprotective drugs. Adv Exp Med Biol. 1993; 331:117-20. PMID: 8333325.
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    240. Zlokovic BV, Mackic JB, Lipovac MN, McComb JG, Weiss MH. Blood-brain transport of vasopressin. Adv Exp Med Biol. 1993; 331:143-7. PMID: 8333329.
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    241. Zlokovic BV, Banks WA, el Kadi H, Erchegyi J, Mackic JB, McComb JG, Kastin AJ. Transport, uptake, and metabolism of blood-borne vasopressin by the blood-brain barrier. Brain Res. 1992 Sep 11; 590(1-2):213-8. PMID: 1422832.
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    242. Zlokovic BV, Mackic JB, McComb JG, Kannan R, Weiss MH. An in situ perfused guinea-pig eye model for blood-ocular transport studies: application to amino acids. Exp Eye Res. 1992 Mar; 54(3):471-7. PMID: 1381681.
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    243. Zlokovic BV, McComb JG, Perlmutter L, Weiss MH, Davson H. Neuroactive peptides and amino acids at the blood-brain barrier: possible implications for drug abuse. NIDA Res Monogr. 1992; 120:26-42. PMID: 1501689.
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    244. Susic V, Reith ME, Zlokovic BV, Lajtha A, Jacobson AE, Rice KC, Lipovac MN. Electroencephalographic characteristics of audiogenic seizures induced in metaphit-treated small rodents. Epilepsia. 1991 Nov-Dec; 32(6):783-90. PMID: 1743149.
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    245. Zlokovic BV, Hyman S, McComb JG, Tang G, Rezai AR, Weiss MH. Vasopressin uptake by hypothalamopituitary axis and pineal gland in guinea pigs. Am J Physiol. 1991 Apr; 260(4 Pt 1):E633-40. PMID: 1902062.
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    246. Zlokovic BV, Segal MB, McComb JG, Hyman S, Weiss MH, Davson H. Kinetics of circulating vasopressin uptake by choroid plexus. Am J Physiol. 1991 Feb; 260(2 Pt 2):F216-24. PMID: 1899978.
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    247. Rosic M, Collis CS, Anjelkovic IZ, Segal MB, Djuric D, Zlokovic BV. The effects of (R) alpha-methyl histamine on the isolated guinea pig aorta. Agents Actions Suppl. 1991; 33:283-7. PMID: 1647128.
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    248. Begley DJ, Squires LK, Zlokovic BV, Mitrovic DM, Hughes CC, Revest PA, Greenwood J. Permeability of the blood-brain barrier to the immunosuppressive cyclic peptide cyclosporin A. J Neurochem. 1990 Oct; 55(4):1222-30. PMID: 2398356.
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    249. Zlokovic BV, Hyman S, McComb JG, Lipovac MN, Tang G, Davson H. Kinetics of arginine-vasopressin uptake at the blood-brain barrier. Biochim Biophys Acta. 1990 Jun 27; 1025(2):191-8. PMID: 2364078.
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    250. Segal MB, Preston JE, Collis CS, Zlokovic BV. Kinetics and Na independence of amino acid uptake by blood side of perfused sheep choroid plexus. Am J Physiol. 1990 May; 258(5 Pt 2):F1288-94. PMID: 2186633.
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    251. Segal MB, Preston JE, Zlokovic B. Comparison between blood and saline perfusion on the uptake of amino acids by choroid plexus of the sheep. Endocrinol Exp. 1990 Mar; 24(1-2):29-36. PMID: 2361466.
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    252. Zlokovic BV, Skundric DS, Segal MB, Lipovac MN, Mackic JB, Davson H. A saturable mechanism for transport of immunoglobulin G across the blood-brain barrier of the guinea pig. Exp Neurol. 1990 Mar; 107(3):263-70. PMID: 1689666.
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    253. Zlokovic BV, Segal MB, Davson H, Lipovac MN, Hyman S, McComb JG. Circulating neuroactive peptides and the blood-brain and blood-cerebrospinal fluid barriers. Endocrinol Exp. 1990 Mar; 24(1-2):9-17. PMID: 2193795.
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    254. Kozlowski GP, Nilaver G, Zlokovic BV. Immunoneurology: a serum protein afferent limb to the CNS. Adv Exp Med Biol. 1990; 274:345-70. PMID: 2239432.
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    255. Rakic LM, Zlokovic BV, Davson H, Segal MB, Begley DJ, Lipovac MN, Mitrovic DM. Chronic amphetamine intoxication and the blood-brain barrier permeability to inert polar molecules studied in the vascularly perfused guinea pig brain. J Neurol Sci. 1989 Dec; 94(1-3):41-50. PMID: 2515257.
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    256. Zlokovic BV, Mackic JB, Djuricic B, Davson H. Kinetic analysis of leucine-enkephalin cellular uptake at the luminal side of the blood-brain barrier of an in situ perfused guinea-pig brain. J Neurochem. 1989 Nov; 53(5):1333-40. PMID: 2795003.
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    257. Debler EA, Lipovac MN, Lajtha A, Zlokovic BV, Jacobson AE, Rice KC, Reith ME. Metaphit, an isothiocyanate analog of PCP, induces audiogenic seizures in mice. Eur J Pharmacol. 1989 Jun 08; 165(1):155-9. PMID: 2548879.
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    258. Zlokovic BV, Skundric DS, Segal MB, Colover J, Jankov RM, Pejnovic N, Lackovic V, Mackic J, Lipovac MN, Davson H. Blood-brain barrier permeability changes during acute allergic encephalomyelitis induced in the guinea pig. Metab Brain Dis. 1989 Mar; 4(1):33-40. PMID: 2495422.
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    259. Zlokovic BV, Susic VT, Davson H, Begley DJ, Jankov RM, Mitrovic DM, Lipovac MN. Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain. Peptides. 1989 Mar-Apr; 10(2):249-54. PMID: 2547200.
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    260. Rakic LM, Zlokovic BV, Segal MB, Lipovac MH, Mitrovic DM, Veskov R, Mackic JB, Davson H. Effects of sensory-motor cortical lesions on blood-brain permeability in guinea pigs. Metab Brain Dis. 1989 Mar; 4(1):9-15. PMID: 2495423.
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    261. Preston JE, Segal MB, Walley GJ, Zlokovic BV. Neutral amino acid uptake by the isolated perfused sheep choroid plexus. J Physiol. 1989 Jan; 408:31-43. PMID: 2506339.
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    262. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. Slow penetration of thyrotropin-releasing hormone across the blood-brain barrier of an in situ perfused guinea pig brain. J Neurochem. 1988 Jul; 51(1):252-7. PMID: 3132534.
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    263. Zlokovic BV, Segal MB, Davson H, Jankov RM. Passage of delta sleep-inducing peptide (DSIP) across the blood-cerebrospinal fluid barrier. Peptides. 1988 May-Jun; 9(3):533-8. PMID: 3420012.
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    264. Zlokovic BV, Andjelkovic IZ. Glucagon effect on myocardial transport and utilization of energy-metabolites from the coronary microcirculation in the perfused rabbit heart. Arch Int Physiol Biochim. 1988 Mar; 96(1):7-16. PMID: 2460051.
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    265. Zlokovic BV, Segal MB, Davson H, Mitrovic DM. Unidirectional uptake of enkephalins at the blood-tissue interface of the blood-cerebrospinal fluid barrier: a saturable mechanism. Regul Pept. 1988 Jan; 20(1):33-44. PMID: 3127863.
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    266. Zlokovic BV, Davson H, Preston JE, Segal MB. The effects of aluminum chloride on the rate of secretion of the cerebrospinal fluid. Exp Neurol. 1987 Nov; 98(2):436-52. PMID: 2444450.
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    267. Zlokovic BV, Lipovac MN, Begley DJ, Davson H, Rakic L. Transport of leucine-enkephalin across the blood-brain barrier in the perfused guinea pig brain. J Neurochem. 1987 Jul; 49(1):310-5. PMID: 3585338.
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    268. Zlokovic BV, Begley DJ, Djuricic BM, Mitrovic DM. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J Neurochem. 1986 May; 46(5):1444-51. PMID: 3083044.
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    269. Zlokovic BV, Segal MB, Begley DJ, Davson H, Rakic L. Permeability of the blood-cerebrospinal fluid and blood-brain barriers to thyrotropin-releasing hormone. Brain Res. 1985 Dec 09; 358(1-2):191-9. PMID: 3935272.
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    270. Mann GE, Zlokovic BV, Yudilevich DL. Evidence for a lactate transport system in the sarcolemmal membrane of the perfused rabbit heart: kinetics of unidirectional influx, carrier specificity and effects of glucagon. Biochim Biophys Acta. 1985 Oct 10; 819(2):241-8. PMID: 4041458.
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    271. Zlokovic BV, Begley DJ, Chain-Eliash DG. Blood-brain barrier permeability to leucine-enkephalin, D-alanine2-D-leucine5-enkephalin and their N-terminal amino acid (tyrosine). Brain Res. 1985 Jun 10; 336(1):125-32. PMID: 3891014.
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    272. Zlokovic BV, Begley DJ, Chain DG. Blood-brain barrier permeability to dipeptides and their constituent amino acids. Brain Res. 1983 Jul 18; 271(1):65-71. PMID: 6883121.
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    273. Andjelkovic I, Zlokovic B. Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol. 1982 Jul; 76(3):483-9. PMID: 6179557.
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