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    Meredith N. Braskie, PhD

    TitleAssistant Professor of Research Neurology
    SchoolKeck School of Medicine of USC
    DepartmentNeurology
    AddressISI, 4676 Admiralty Way, Ste. 200
    Health Sciences Campus
    Marina Del Rey California 90292
    Phone+1 323 442 7246
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      My research focus is to evaluate how genetic and environmental risk factors for Alzheimer's disease (AD) relate to brain structure, function, and connectivity throughout adulthood, with an emphasis on cognitively intact adults and those with early mild cognitive impairment. We also seek to understand the biological mechanisms and signaling pathways that may contribute to or protect against AD-related changes, using relevant blood and cerebrospinal fluid measures, and multimodal imaging (structural and functional MRI, diffusion tensor imaging, and PET). When possible, we engage in collaborative research with laboratories investigating similar concepts in a wet lab environment.


      Collapse Biography 
      Collapse Awards and Honors
      2011Turken Award for Alzheimer’s Disease Research
      2009  - 2010Ruth L. Kirschstein National Research Service Award
      2004  - 2006Achievement Rewards for College Scientists (ARCS) fellowship
      2003  - 2006Ruth L Kirschstein National Research Service Award

      Collapse ORNG Applications 
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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Nashiro K, Sakaki M, Braskie M, Mather M. Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing. Neurobiol Aging. 2017 Mar 11. PMID: 28390824.
        View in: PubMed
      2. Yassine HN, Braskie M, Mack WJ, Castor KJ, Fonteh AN, Schneider LS, Harrington MG, Chui HC. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review. JAMA Neurol. 2017 Mar 01; 74(3):339-347. PMID: 28114437.
        View in: PubMed
      3. Scott JA, Tosun D, Braskie M, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Independent value added by diffusion MRI for prediction of cognitive function in older adults. Neuroimage Clin. 2017; 14:166-173. PMID: 28180075.
        View in: PubMed
      4. Nashiro K, Guevara-Aguirre J, Braskie M, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD. Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans. J Neurosci. 2017 Feb 15; 37(7):1696-1707. PMID: 28073935.
        View in: PubMed
      5. Wang J, Braskie M, Hafzalla GW, Faskowitz J, McMahon KL, de Zubicaray GI, Wright MJ, Yu C, Thompson PM. Relationship of a common OXTR gene variant to brain structure and default mode network function in healthy humans. Neuroimage. 2017 Feb 15; 147:500-506. PMID: 28017919.
        View in: PubMed
      6. Scott JA, Braskie M, Tosun D, Maillard P, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral amyloid is associated with greater white-matter hyperintensity accrual in cognitively normal older adults. Neurobiol Aging. 2016 Dec; 48:48-52. PMID: 27639120.
        View in: PubMed
      7. Soosman SK, Joseph-Mathurin N, Braskie M, Bordelon YM, Wharton D, Casado M, Coppola G, McCallum H, Nuwer M, Coutin-Churchman P, Apostolova LG, Benzinger T, Ringman JM. Widespread white matter and conduction defects in PSEN1-related spastic paraparesis. Neurobiol Aging. 2016 Nov; 47:201-209. PMID: 27614114.
        View in: PubMed
      8. Scott JA, Braskie M, Tosun D, Thompson PM, Weiner M, DeCarli C, Carmichael OT. Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. Front Aging Neurosci. 2015; 7:221. PMID: 26648866; PMCID: PMC4664630.
      9. Dennis EL, Jahanshad N, Braskie M, Warstadt NM, Hibar DP, Kohannim O, Nir TM, McMahon KL, de Zubicaray GI, Montgomery GW, Martin NG, Toga AW, Wright MJ, Thompson PM. Obesity gene NEGR1 associated with white matter integrity in healthy young adults. Neuroimage. 2014 Nov 15; 102 Pt 2:548-57. PMID: 25072390; PMCID: PMC4269485.
      10. Braskie M, Boyle CP, Rajagopalan P, Gutman BA, Toga AW, Raji CA, Tracy RP, Kuller LH, Becker JT, Lopez OL, Thompson PM. Physical activity, inflammation, and volume of the aging brain. Neuroscience. 2014 Jul 25; 273:199-209. PMID: 24836855; PMCID: PMC4076831.
      11. Braskie M, Thompson PM. A focus on structural brain imaging in the Alzheimer's disease neuroimaging initiative. Biol Psychiatry. 2014 Apr 01; 75(7):527-33. PMID: 24367935; PMCID: PMC4019004.
      12. Braskie M, Thompson PM. Understanding cognitive deficits in Alzheimer's disease based on neuroimaging findings. Trends Cogn Sci. 2013 Oct; 17(10):510-6. PMID: 24029445; PMCID: PMC3947610.
      13. Braskie M, Kohannim O, Jahanshad N, Chiang MC, Barysheva M, Toga AW, Ringman JM, Montgomery GW, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM. Relation between variants in the neurotrophin receptor gene, NTRK3, and white matter integrity in healthy young adults. Neuroimage. 2013 Nov 15; 82:146-53. PMID: 23727532; PMCID: PMC3948328.
      14. Braskie M, Toga AW, Thompson PM. Recent advances in imaging Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S313-27. PMID: 22672880; PMCID: PMC4110110.
      15. Lee GJ, Lu PH, Medina LD, Rodriguez-Agudelo Y, Melchor S, Coppola G, Braskie M, Hua X, Apostolova LG, Leow AD, Thompson PM, Ringman JM. Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer's disease mutations. J Neurol Neurosurg Psychiatry. 2013 Feb; 84(2):154-62. PMID: 23085935; PMCID: PMC3779052.
      16. Braskie M, Jahanshad N, Toga AW, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Thompson PM. How a common variant in the growth factor receptor gene, NTRK1, affects white matter. Bioarchitecture. 2012 Sep-Oct; 2(5):181-4. PMID: 22986407; PMCID: PMC3696063.
      17. Braskie M, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Thompson PM, Cummings JL, Bookheimer SY, Ringman JM. Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease. Hum Brain Mapp. 2013 Dec; 34(12):3308-19. PMID: 22806961; PMCID: PMC3812259.
      18. Braskie M, Jahanshad N, Stein JL, Barysheva M, Johnson K, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Relationship of a variant in the NTRK1 gene to white matter microstructure in young adults. J Neurosci. 2012 Apr 25; 32(17):5964-72. PMID: 22539856; PMCID: PMC3393752.
      19. Kohannim O, Jahanshad N, Braskie M, Stein JL, Chiang MC, Reese AH, Hibar DP, Toga AW, McMahon KL, de Zubicaray GI, Medland SE, Montgomery GW, Martin NG, Wright MJ, Thompson PM. Predicting white matter integrity from multiple common genetic variants. Neuropsychopharmacology. 2012 Aug; 37(9):2012-9. PMID: 22510721; PMCID: PMC3398730.
      20. Protas HD, Kepe V, Hayashi KM, Klunder AD, Braskie M, Ercoli L, Siddarth P, Bookheimer SY, Thompson PM, Small GW, Barrio JR, Huang SC. Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET. Neuroimage. 2012 Jul 16; 61(4):749-60. PMID: 22401755; PMCID: PMC3839850.
      21. Apostolova LG, Hwang KS, Medina LD, Green AE, Braskie M, Dutton RA, Lai J, Geschwind DH, Cummings JL, Thompson PM, Ringman JM. Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dement Geriatr Cogn Disord. 2011; 32(2):118-25. PMID: 21952501; PMCID: PMC3222115.
      22. Braskie M, Jahanshad N, Stein JL, Barysheva M, McMahon KL, de Zubicaray GI, Martin NG, Wright MJ, Ringman JM, Toga AW, Thompson PM. Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci. 2011 May 04; 31(18):6764-70. PMID: 21543606; PMCID: PMC3176803.
      23. Klostermann EC, Braskie M, Landau SM, O'Neil JP, Jagust WJ. Dopamine and frontostriatal networks in cognitive aging. Neurobiol Aging. 2012 Mar; 33(3):623.e15-24. PMID: 21511369; PMCID: PMC3245323.
      24. Braskie M, Ringman JM, Thompson PM. Neuroimaging measures as endophenotypes in Alzheimer's disease. Int J Alzheimers Dis. 2011 Mar 31; 2011:490140. PMID: 21547229; PMCID: PMC3087508.
      25. Braskie M, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer SY, Ringman JM. Increased fMRI signal with age in familial Alzheimer's disease mutation carriers. Neurobiol Aging. 2012 Feb; 33(2):424.e11-21. PMID: 21129823; PMCID: PMC3097258.
      26. Ringman JM, Medina LD, Braskie M, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer S. Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cereb Cortex. 2011 Apr; 21(4):877-83. PMID: 20729396; PMCID: PMC3059887.
      27. Braskie M, Landau SM, Wilcox CE, Taylor SD, O'Neil JP, Baker SL, Madison CM, Jagust WJ. Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Hum Brain Mapp. 2011 Jun; 32(6):947-61. PMID: 20578173; PMCID: PMC3176660.
      28. Wilcox CE, Braskie M, Kluth JT, Jagust WJ. Overeating Behavior and Striatal Dopamine with 6-[F]-Fluoro-L-m-Tyrosine PET. J Obes. 2010; 2010. PMID: 20798859; PMCID: PMC2925447.
      29. Braskie M, Small GW, Bookheimer SY. Entorhinal cortex structure and functional MRI response during an associative verbal memory task. Hum Brain Mapp. 2009 Dec; 30(12):3981-92. PMID: 19507155; PMCID: PMC2787760.
      30. Protas HD, Huang SC, Kepe V, Hayashi K, Klunder A, Braskie M, Ercoli L, Bookheimer S, Thompson PM, Small GW, Barrio JR. FDDNP binding using MR derived cortical surface maps. Neuroimage. 2010 Jan 01; 49(1):240-8. PMID: 19703569; PMCID: PMC2764817.
      31. Braskie M, Wilcox CE, Landau SM, O'Neil JP, Baker SL, Madison CM, Kluth JT, Jagust WJ. Relationship of striatal dopamine synthesis capacity to age and cognition. J Neurosci. 2008 Dec 24; 28(52):14320-8. PMID: 19109513; PMCID: PMC2880923.
      32. Braskie M, Klunder AD, Hayashi KM, Protas H, Kepe V, Miller KJ, Huang SC, Barrio JR, Ercoli LM, Siddarth P, Satyamurthy N, Liu J, Toga AW, Bookheimer SY, Small GW, Thompson PM. Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease. Neurobiol Aging. 2010 Oct; 31(10):1669-78. PMID: 19004525; PMCID: PMC2891885.
      33. Braskie M, Small GW, Bookheimer SY. Vascular health risks and fMRI activation during a memory task in older adults. Neurobiol Aging. 2010 Sep; 31(9):1532-42. PMID: 18829134; PMCID: PMC2965069.
      34. Burggren AC, Zeineh MM, Ekstrom AD, Braskie M, Thompson PM, Small GW, Bookheimer SY. Reduced cortical thickness in hippocampal subregions among cognitively normal apolipoprotein E e4 carriers. Neuroimage. 2008 Jul 15; 41(4):1177-83. PMID: 18486492; PMCID: PMC2601686.
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