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Vasilis Marmarelis, PhD

Title(s)Professor Of Biomedical Engineering And Electrical Engineering - Systems
Phone+1 213 740 0841
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    Vasilis Z. Marmarelis received his diploma in Electrical and Mechanical Engineering from the National Technical University of Athens in 1972 and his M.S. and Ph.D. in Engineering Science (Bio-Information Systems) from the California Institute of Technology in 1973 and 1976, respectively. He was Simon Ramo Lecturer and Research Fellow at the California Institute of Technology from 1976 to 1978. In September 1978, he joined the faculty of the Biomedical and Electrical Engineering Departments at USC, where he is currently Professor and Co-Director of the Biomedical Simulations Resource (BMSR), a research center dedicated to modeling and simulation of physiological systems that has been funded by the NIH through multi-million dollar grants since 1985. Dr. Marmarelis served as Chairman of the Biomedical Engineering Department from 1990 to 1996 and he is a Fellow of the IEEE and the AIMBE.

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    Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression.
    NIH/NIA R01AG058162Sep 1, 2018 - May 31, 2023
    Role: Principal Investigator
    Biomedical Simulations Resource (BMSR)
    NIH/NIBIB P41EB001978Sep 30, 1997 - Aug 31, 2018
    Role: Co-Principal Investigator
    BIOMEDICAL SIMULATIONS RESOURCE
    NIH/NCRR P41RR001861Sep 30, 1985 - Sep 29, 1998
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Elting JW, Sanders ML, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Müller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR. Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability? PLoS One. 2020; 15(1):e0227651. PMID: 31923919.
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    2. Marmarelis VZ, Shin DC, Oesterreich M, Mueller M. Quantification of dynamic cerebral autoregulation and CO2 dynamic vasomotor reactivity impairment in essential hypertension. J Appl Physiol (1985). 2020 Jan 09. PMID: 31917625.
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    3. Marmarelis VZ, Shin DC, Tarumi T, Zhang R. Comparing model-based cerebrovascular physiomarkers with DTI biomarkers in MCI patients. Brain Behav. 2019 08; 9(8):e01356. PMID: 31286695.
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    4. Sanders ML, Elting JWJ, Panerai RB, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Müller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Claassen JAHR. Dynamic Cerebral Autoregulation Reproducibility Is Affected by Physiological Variability. Front Physiol. 2019; 10:865. PMID: 31354518.
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    5. Marmarelis VZ, Shin DC, Zhang R. Closed-loop modeling of the heart-rate reflex for improved diagnosis and monitoring of Mild Cognitive Impairment. Conf Proc IEEE Eng Med Biol Soc. 2019 Jul; 2019:1879-1882. PMID: 31946264.
      View in: PubMed
    6. Geng K, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ. Multi-Input, Multi-Output Neuronal Mode Network Approach to Modeling the Encoding Dynamics and Functional Connectivity of Neural Systems. Neural Comput. 2019 Jul; 31(7):1327-1355. PMID: 31113305.
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    7. Sanders ML, Claassen JAHR, Aries M, Bor-Seng-Shu E, Caicedo A, Chacon M, Gommer ED, Van Huffel S, Jara JL, Kostoglou K, Mahdi A, Marmarelis VZ, Mitsis GD, Müller M, Nikolic D, Nogueira RC, Payne SJ, Puppo C, Shin DC, Simpson DM, Tarumi T, Yelicich B, Zhang R, Panerai RB, Elting JWJ. Reproducibility of dynamic cerebral autoregulation parameters: a multi-centre, multi-method study. Physiol Meas. 2018 12 07; 39(12):125002. PMID: 30523976.
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    8. Hampson RE, Song D, Robinson BS, Fetterhoff D, Dakos AS, Roeder BM, She X, Wicks RT, Witcher MR, Couture DE, Laxton AW, Munger-Clary H, Popli G, Sollman MJ, Whitlow CT, Marmarelis VZ, Berger TW, Deadwyler SA. Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall. J Neural Eng. 2018 06; 15(3):036014. PMID: 29589592.
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    9. Sandler RA, Geng K, Song D, Hampson RE, Witcher MR, Deadwyler SA, Berger TW, Marmarelis VZ. Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression. Neural Comput. 2018 05; 30(5):1180-1208. PMID: 29566356.
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    10. Geng K, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ. Mechanism-Based and Input-Output Modeling of the Key Neuronal Connections and Signal Transformations in the CA3-CA1 Regions of the Hippocampus. Neural Comput. 2018 01; 30(1):149-183. PMID: 29064783.
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    11. Sandler RA, Fetterhoff D, Hampson RE, Deadwyler SA, Marmarelis VZ. Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3. PLoS Comput Biol. 2017 Jul; 13(7):e1005624. PMID: 28686594.
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    12. Lytton WW, Arle J, Bobashev G, Ji S, Klassen TL, Marmarelis VZ, Schwaber J, Sherif MA, Sanger TD. Multiscale modeling in the clinic: diseases of the brain and nervous system. Brain Inform. 2017 Dec; 4(4):219-230. PMID: 28488252.
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    13. Marmarelis VZ, Shin DC, Tarumi T, Zhang R. Comparison of Model-Based Indices of Cerebral Autoregulation and Vasomotor Reactivity Using Transcranial Doppler versus Near-Infrared Spectroscopy in Patients with Amnestic Mild Cognitive Impairment. J Alzheimers Dis. 2017; 56(1):89-105. PMID: 27911329.
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    14. Song D, Robinson BS, Hampson RE, Marmarelis VZ, Deadwyler SA, Berger TW. Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses. IEEE Trans Neural Syst Rehabil Eng. 2018 02; 26(2):272-280. PMID: 28113595.
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    15. Cole M, Eikenberry S, Kato T, Sandler RA, Yamashiro SM, Marmarelis VZ. Nonparametric Model of Smooth Muscle Force Production During Electrical Stimulation. J Comput Biol. 2017 Mar; 24(3):229-237. PMID: 27494114.
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    16. Hampson RE, Robinson BS, Marmarelis VZ, Deadwyler SA, Berger TW. Decoding memory features from hippocampal spiking activities using sparse classification models. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:1620-1623. PMID: 28268639.
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    17. Henley BC, Shin DC, Zhang R, Marmarelis VZ. Compartmental and Data-Based Modeling of Cerebral Hemodynamics: Nonlinear Analysis. IEEE Trans Biomed Eng. 2017 05; 64(5):1078-1088. PMID: 27411214.
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    18. Geng K, Marmarelis VZ. Methodology of Recurrent Laguerre-Volterra Network for Modeling Nonlinear Dynamic Systems. IEEE Trans Neural Netw Learn Syst. 2017 09; 28(9):2196-2208. PMID: 27352401.
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    19. Deadwyler SA, Hampson RE, Song D, Opris I, Gerhardt GA, Marmarelis VZ, Berger TW. A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain. Exp Neurol. 2017 01; 287(Pt 4):452-460. PMID: 27233622.
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    20. Marmarelis VZ, Mitsis GD, Shin DC, Zhang R. Multiple-input nonlinear modelling of cerebral haemodynamics using spontaneous arterial blood pressure, end-tidal CO2 and heart rate measurements. Philos Trans A Math Phys Eng Sci. 2016 May 13; 374(2067). PMID: 27044989.
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    21. Henley BC, Shin DC, Zhang R, Marmarelis VZ. Compartmental and Data-Based Modeling of Cerebral Hemodynamics: Linear Analysis. IEEE Access. 2015; 3:2317-2332. PMID: 26900535.
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    22. Fetterhoff D, Kraft RA, Sandler RA, Opris I, Sexton CA, Marmarelis VZ, Hampson RE, Deadwyler SA. Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences. Front Syst Neurosci. 2015; 9:130. PMID: 26441562.
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    23. Sandler RA, Song D, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ. Hippocampal closed-loop modeling and implications for seizure stimulation design. J Neural Eng. 2015 Oct; 12(5):056017. PMID: 26355815.
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    24. Kang Y, Escudero J, Shin D, Ifeachor E, Marmarelis V. Principal Dynamic Mode Analysis of EEG Data for Assisting the Diagnosis of Alzheimer's Disease. IEEE J Transl Eng Health Med. 2015; 3:1800110. PMID: 27170890.
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    25. Sandler RA, Marmarelis VZ. Understanding spike-triggered covariance using Wiener theory for receptive field identification. J Vis. 2015; 15(9):16. PMID: 26230978.
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    26. Song D, Robinson BS, Hampson RE, Marmarelis VZ, Deadwyler SA, Berger TW. Sparse generalized volterra model of human hippocampal spike train transformation for memory prostheses. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:3961-4. PMID: 26737161.
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    27. Sandler RA, Deadwyler SA, Hampson RE, Song D, Berger TW, Marmarelis VZ. System identification of point-process neural systems using probability based Volterra kernels. J Neurosci Methods. 2015 Jan 30; 240:179-92. PMID: 25479231.
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    28. Eikenberry SE, Marmarelis VZ. Principal dynamic mode analysis of the Hodgkin-Huxley equations. Int J Neural Syst. 2015 Mar; 25(2):1550001. PMID: 25630480.
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    29. Song D, Chan RH, Robinson BS, Marmarelis VZ, Opris I, Hampson RE, Deadwyler SA, Berger TW. Identification of functional synaptic plasticity from spiking activities using nonlinear dynamical modeling. J Neurosci Methods. 2015 Apr 15; 244:123-35. PMID: 25280984.
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    30. Sandler RA, Song D, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ. Model-based asessment of an in-vivo predictive relationship from CA1 to CA3 in the rodent hippocampus. J Comput Neurosci. 2015 Feb; 38(1):89-103. PMID: 25260381.
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    31. Zografos G, Liakou P, Koulocheri D, Liovarou I, Sofras M, Hadjiagapis S, Orme M, Marmarelis V. Differentiation of BIRADS-4 small breast lesions via Multimodal Ultrasound Tomography. Eur Radiol. 2015 Feb; 25(2):410-8. PMID: 25218763.
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    32. Song D, Harway M, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Extraction and restoration of hippocampal spatial memories with non-linear dynamical modeling. Front Syst Neurosci. 2014; 8:97. PMID: 24904318.
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    33. Meel-van den Abeelen AS, Simpson DM, Wang LJ, Slump CH, Zhang R, Tarumi T, Rickards CA, Payne S, Mitsis GD, Kostoglou K, Marmarelis V, Shin D, Tzeng YC, Ainslie PN, Gommer E, Müller M, Dorado AC, Smielewski P, Yelicich B, Puppo C, Liu X, Czosnyka M, Wang CY, Novak V, Panerai RB, Claassen JA. Between-centre variability in transfer function analysis, a widely used method for linear quantification of the dynamic pressure-flow relation: the CARNet study. Med Eng Phys. 2014 May; 36(5):620-7. PMID: 24725709.
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    34. Marmarelis VZ, Shin DC, Orme ME, Zhang R. Model-based physiomarkers of cerebral hemodynamics in patients with mild cognitive impairment. Med Eng Phys. 2014 May; 36(5):628-37. PMID: 24698010.
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    35. Deadwyler SA, Berger TW, Sweatt AJ, Song D, Chan RH, Opris I, Gerhardt GA, Marmarelis VZ, Hampson RE. Donor/recipient enhancement of memory in rat hippocampus. Front Syst Neurosci. 2013; 7:120. PMID: 24421759.
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    36. Hampson RE, Song D, Opris I, Santos LM, Shin DC, Gerhardt GA, Marmarelis VZ, Berger TW, Deadwyler SA. Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing. J Neural Eng. 2013 Dec; 10(6):066013. PMID: 24216292.
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    37. Marmarelis VZ, Shin DC, Orme M. Time-varying modeling of cerebral hemodynamics. IEEE Trans Biomed Eng. 2014 Mar; 61(3):694-704. PMID: 24184697.
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    38. Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW. On parsing the neural code in the prefrontal cortex of primates using principal dynamic modes. J Comput Neurosci. 2014 Jun; 36(3):321-37. PMID: 23929124.
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    39. Marmarelis VZ, Shin DC, Zhang Y, Kautzky-Willer A, Pacini G, D'Argenio DZ. Analysis of intravenous glucose tolerance test data using parametric and nonparametric modeling: application to a population at risk for diabetes. J Diabetes Sci Technol. 2013 Jul 01; 7(4):952-62. PMID: 23911176.
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    40. Marmarelis VZ, Shin DC, Orme ME, Zhang R. Model-based quantification of cerebral hemodynamics as a physiomarker for Alzheimer's disease? Ann Biomed Eng. 2013 Nov; 41(11):2296-317. PMID: 23771298.
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    41. Song D, Wang H, Tu CY, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Identification of sparse neural functional connectivity using penalized likelihood estimation and basis functions. J Comput Neurosci. 2013 Dec; 35(3):335-57. PMID: 23674048.
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    42. Marmarelis VZ, Shin DC, Orme ME, Zhang R. Closed-loop dynamic modeling of cerebral hemodynamics. Ann Biomed Eng. 2013 May; 41(5):1029-48. PMID: 23292615.
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    43. Hampson RE, Fuqua JL, Huettl PF, Opris I, Song D, Shin D, Marmarelis VZ, Berger TW, Gerhardt GA, Deadwyler SA. Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:5954-7. PMID: 24111095.
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    44. Marmarelis VZ, Shin DC, Hampson RE, Deadwyler SA, Song D, Berger TW. Design of optimal stimulation patterns for neuronal ensembles based on Volterra-type hierarchical modeling. J Neural Eng. 2012 Dec; 9(6):066003. PMID: 23075519.
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    45. Zografos G, Koulocheri D, Liakou P, Sofras M, Hadjiagapis S, Orme M, Marmarelis V. Novel technology of multimodal ultrasound tomography detects breast lesions. Eur Radiol. 2013 Mar; 23(3):673-83. PMID: 22983317.
      View in: PubMed
    46. Hampson RE, Gerhardt GA, Marmarelis V, Song D, Opris I, Santos L, Berger TW, Deadwyler SA. Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing. J Neural Eng. 2012 Oct; 9(5):056012. PMID: 22976769.
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    47. Berger T, Song D, Chan R, Shin D, Marmarelis V, Hampson R, Sweatt A, Heck C, Liu C, Wills J, Lacoss J, Granacki J, Gerhardt G, Deadwyler S. Role of the hippocampus in memory formation: restorative encoding memory integration neural device as a cognitive neural prosthesis. IEEE Pulse. 2012 Sep-Oct; 3(5):17-22. PMID: 23014702.
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    48. Eikenberry SE, Marmarelis VZ. A nonlinear autoregressive Volterra model of the Hodgkin-Huxley equations. J Comput Neurosci. 2013 Feb; 34(1):163-83. PMID: 22878687.
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    49. Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW. Nonlinear modeling of dynamic interactions within neuronal ensembles using Principal Dynamic Modes. J Comput Neurosci. 2013 Feb; 34(1):73-87. PMID: 23011343.
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    50. Berger T, Meng E, George S, Khoo M, Marmarelis V, McCulloch A, Cauwenberghs G, Ohno-Machado L, Schultz J, Johnson JP. Southern California: a hotbed of biomedical engineering: nine bioengineers describe their research and why Southern California has the biotech market cornered. IEEE Pulse. 2012 Jul; 3(4):14-21. PMID: 23008840.
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    51. Hampson RE, Song D, Chan RH, Sweatt AJ, Riley MR, Goonawardena AV, Marmarelis VZ, Gerhardt GA, Berger TW, Deadwyler SA. Closing the loop for memory prosthesis: detecting the role of hippocampal neural ensembles using nonlinear models. IEEE Trans Neural Syst Rehabil Eng. 2012 Jul; 20(4):510-25. PMID: 22498704.
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    52. Hampson RE, Song D, Chan RH, Sweatt AJ, Riley MR, Gerhardt GA, Shin DC, Marmarelis VZ, Berger TW, Deadwyler SA. A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation. IEEE Trans Neural Syst Rehabil Eng. 2012 Mar; 20(2):184-97. PMID: 22438334.
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    53. Berger TW, Song D, Chan RH, Marmarelis VZ, LaCoss J, Wills J, Hampson RE, Deadwyler SA, Granacki JJ. A hippocampal cognitive prosthesis: multi-input, multi-output nonlinear modeling and VLSI implementation. IEEE Trans Neural Syst Rehabil Eng. 2012 Mar; 20(2):198-211. PMID: 22438335.
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    54. Ghaderi VS, Roach S, Song D, Marmarelis VZ, Choma J, Berger TW. Analog low-power hardware implementation of a Laguerre-Volterra model of intracellular subthreshold neuronal activity. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:767-70. PMID: 23366005.
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    55. Song D, Opris I, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Functional connectivity between Layer 2/3 and Layer 5 neurons in prefrontal cortex of nonhuman primates during a delayed match-to-sample task. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:2555-8. PMID: 23366446.
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    56. Zanos S, Zanos TP, Marmarelis VZ, Ojemann GA, Fetz EE. Relationships between spike-free local field potentials and spike timing in human temporal cortex. J Neurophysiol. 2012 Apr; 107(7):1808-21. PMID: 22157112.
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    57. Coatrieux JL, Frangi AF, Peng GC, D'Argenio DZ, Marmarelis VZ, Michailova A. Editorial: TBME Letters special issue on multiscale modeling and analysis in computational biology and medicine--part-2. IEEE Trans Biomed Eng. 2011 Dec; 58(12):3434-9. PMID: 22105190.
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    58. Frangi AF, Coatrieux JL, Peng GC, D'Argenio DZ, Marmarelis VZ, Michailova A. Editorial: Special issue on multiscale modeling and analysis in computational biology and medicine--part-1. IEEE Trans Biomed Eng. 2011 Oct; 58(10):2936-42. PMID: 21937299.
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    59. Hampson RE, Sweatt AJ, Goonawardena AV, Song D, Chan RH, Marmarelis VZ, Berger TW, Deadwyler SA. Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors. Behav Pharmacol. 2011 Aug; 22(4):335-46. PMID: 21558844.
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    60. Berger TW, Hampson RE, Song D, Goonawardena A, Marmarelis VZ, Deadwyler SA. A cortical neural prosthesis for restoring and enhancing memory. J Neural Eng. 2011 Aug; 8(4):046017. PMID: 21677369.
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    61. Marmarelis VZ, Shin DC, Diaz-Arrastia R, Zhang R. Diagnostic biomarkers for Alzheimer's disease using dynamic nonlinear models based on Principal Dynamic Modes. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:7119-22. PMID: 22255979.
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    62. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Estimation and statistical validation of event-invariant nonlinear dynamic models of hippocampal CA3-CA1 population activities. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3330-3. PMID: 22255052.
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    63. Marmarelis VZ, Shin DC, Song D, Hampson RE, Deadwyler SA, Berger TW. Dynamic nonlinear modeling of interactions between neuronal ensembles using principal dynamic modes. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3334-7. PMID: 22255053.
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    64. Markakis MG, Mitsis GD, Papavassilopoulos GP, Ioannou PA, Marmarelis VZ. A switching control strategy for the attenuation of blood glucose disturbances. Optim Control Appl Methods. 2011; 32(2):185-195. PMID: 21516241.
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    65. Berger TW, Song D, Chan RH, Marmarelis VZ. The Neurobiological Basis of Cognition: Identification by Multi-Input, Multioutput Nonlinear Dynamic Modeling: A method is proposed for measuring and modeling human long-term memory formation by mathematical analysis and computer simulation of nerve-cell dynamics. Proc IEEE Inst Electr Electron Eng. 2010 Mar 04; 98(3):356-374. PMID: 20700470.
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    66. Mitsis GD, Zhang R, Levine BD, Tzanalaridou E, Katritsis DG, Marmarelis VZ. Autonomic neural control of cerebral hemodynamics. IEEE Eng Med Biol Mag. 2009 Nov-Dec; 28(6):54-62. PMID: 19914889.
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    67. Marmarelis VZ, Zanos TP, Berger TW. Boolean modeling of neural systems with point-process inputs and outputs. Part I: theory and simulations. Ann Biomed Eng. 2009 Aug; 37(8):1654-67. PMID: 19517238.
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    68. Zanos TP, Hampson RE, Deadwyler SE, Berger TW, Marmarelis VZ. Boolean modeling of neural systems with point-process inputs and outputs. Part II: Application to the rat hippocampus. Ann Biomed Eng. 2009 Aug; 37(8):1668-82. PMID: 19499341.
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    69. Mitsis GD, Markakis MG, Marmarelis VZ. Nonlinear modeling of the dynamic effects of infused insulin on glucose: comparison of compartmental with Volterra models. IEEE Trans Biomed Eng. 2009 Oct; 56(10):2347-58. PMID: 19497805.
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    70. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Nonlinear modeling of neural population dynamics for hippocampal prostheses. Neural Netw. 2009 Nov; 22(9):1340-51. PMID: 19501484.
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    71. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Sparse generalized Laguerre-Volterra model of neural population dynamics. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4555-8. PMID: 19963836.
      View in: PubMed
    72. Zanos TP, Courellis SH, Berger TW, Hampson RE, Deadwyler SA, Marmarelis VZ. Nonlinear modeling of causal interrelationships in neuronal ensembles. IEEE Trans Neural Syst Rehabil Eng. 2008 Aug; 16(4):336-52. PMID: 18701382.
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    73. Song D, Marmarelis VZ, Berger TW. Parametric and non-parametric modeling of short-term synaptic plasticity. Part I: Computational study. J Comput Neurosci. 2009 Feb; 26(1):1-19. PMID: 18506609.
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    74. Song D, Wang Z, Marmarelis VZ, Berger TW. Parametric and non-parametric modeling of short-term synaptic plasticity. Part II: Experimental study. J Comput Neurosci. 2009 Feb; 26(1):21-37. PMID: 18504530.
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    75. Jeong JW, Shin DC, Do SH, Blanco C, Klipfel NE, Holmes DR, Hovanessian-Larsen LJ, Marmarelis VZ. Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography. J Ultrasound Med. 2008 Mar; 27(3):435-51. PMID: 18314522.
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    76. Dimoka A, Courellis SH, Marmarelis VZ, Berger TW. Modeling the nonlinear dynamic interactions of afferent pathways in the dentate gyrus of the hippocampus. Ann Biomed Eng. 2008 May; 36(5):852-64. PMID: 18299993.
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    77. Dimoka A, Courellis SH, Gholmieh GI, Marmarelis VZ, Berger TW. Modeling the nonlinear properties of the in vitro hippocampal perforant path-dentate system using multielectrode array technology. IEEE Trans Biomed Eng. 2008 Feb; 55(2 Pt 1):693-702. PMID: 18270006.
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    78. Markakis MG, Mitsis GD, Marmarelis VZ. Computational study of an augmented minimal model for glycaemia control. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:5445-8. PMID: 19163949.
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    79. Markakis MG, Mitsis GD, Papavassilopoulos GP, Marmarelis VZ. Model Predictive Control of blood glucose in Type 1 diabetes: the Principal Dynamic Modes approach. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:5466-9. PMID: 19163954.
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    80. Zanos TP, Hampson RE, Deadwyler SA, Berger TW, Marmarelis VZ. Functional connectivity through nonlinear modeling: an application to the rat hippocampus. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:5522-5. PMID: 19163968.
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    81. Song D, Hendrickson P, Marmarelis VZ, Aguayo J, He J, Loeb GE, Berger TW. Predicting EMG with generalized Volterra kernel model. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:201-4. PMID: 19162628.
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    82. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Nonlinear dynamic modeling of spike train transformations for hippocampal-cortical prostheses. IEEE Trans Biomed Eng. 2007 Jun; 54(6 Pt 1):1053-66. PMID: 17554824.
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    83. Gholmieh G, Courellis S, Marmarelis V, Berger T. Nonlinear dynamic model of CA1 short-term plasticity using random impulse train stimulation. Ann Biomed Eng. 2007 May; 35(5):847-57. PMID: 17380396.
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    84. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Statistical selection of multiple-input multiple-output nonlinear dynamic models of spike train transformation. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:4727-30. PMID: 18003061.
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    85. Mitsis GD, Marmarelis VZ. Nonlinear modeling of glucose metabolism: comparison of parametric vs. nonparametric methods. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:5968-71. PMID: 18003373.
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    86. Mitsis GD, Debert CT, Hajo MI, Marmarelis VZ, Poulin MJ. Nonlinear, multiple-input modeling of cerebral hemodynamics during baseline and hypercapnia in young and post-menopausal women. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:2855-8. PMID: 18002590.
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    87. Gholmieh GI, Courellis SH, Fluster D, Chen LS, Marmarelis VZ, Baudry M, Berger TW. Improving bioassay sensitivity for neurotoxins detection using volterra based third order nonlinear analysis. Conf Proc IEEE Eng Med Biol Soc. 2007; 2007:2261-4. PMID: 18002441.
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    88. Mitsis GD, French AS, Höger U, Courellis S, Marmarelis VZ. Principal dynamic mode analysis of action potential firing in a spider mechanoreceptor. Biol Cybern. 2007 Jan; 96(1):113-27. PMID: 17021828.
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    89. Jeong JW, Shin DC, Do S, Marmarelis VZ. Segmentation methodology for automated classification and differentiation of soft tissues in multiband images of high-resolution ultrasonic transmission tomography. IEEE Trans Med Imaging. 2006 Aug; 25(8):1068-78. PMID: 16894999.
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    90. Mitsis GD, Zhang R, Levine BD, Marmarelis VZ. Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling. J Appl Physiol (1985). 2006 Jul; 101(1):354-66. PMID: 16514006.
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    92. Hsiao MC, Chan CH, Srinivasan V, Ahuja A, Erinjippurath G, Zanos TP, Gholmieh G, Song D, Wills JD, LaCoss J, Courellis S, Tanguay AR, Granacki JJ, Marmarelis VZ, Berger TW. VLSI implementation of a nonlinear neuronal model: a "neural prosthesis" to restore hippocampal trisynaptic dynamics. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4396-9. PMID: 17946244.
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    93. Dimoka A, Courellis SH, Marmarelis VZ, Berger TW. Modeling the nonlinear dynamic interactions of the lateral and the medial perforant path of the hippocampal dentate gyrus. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:5539-42. PMID: 17946313.
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    95. Song D, Chan RH, Marmarelis VZ, Hampson RE, Deadwyler SA, Berger TW. Physiologically plausible stochastic nonlinear kernel models of spike train to spike train transformation. Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:6129-32. PMID: 17946359.
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    96. Zanos TP, Courellis SH, Hampson RE, Deadwyler SA, Marmarelis VZ, Berger TW. A multi-input modeling approach to quantify hippocampal nonlinear dynamic transformations. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4967-70. PMID: 17946273.
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    97. Xie X, Song D, Wang Z, Marmarelis VZ, Berger TW. Interaction of short-term neuronal plasticity and synaptic plasticity revealed by nonlinear systems analysis in dentate granule cells. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:5543-6. PMID: 17946314.
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    98. Berger TW, Ahuja A, Courellis SH, Deadwyler SA, Erinjippurath G, Gerhardt GA, Gholmieh G, Granacki JJ, Hampson R, Hsaio MC, LaCoss J, Marmarelis VZ, Nasiatka P, Srinivasan V, Song D, Tanguay AR, Wills J. Restoring lost cognitive function. IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):30-44. PMID: 16248115.
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    99. Marmarelis VZ, Berger TW. General methodology for nonlinear modeling of neural systems with Poisson point-process inputs. Math Biosci. 2005 Jul; 196(1):1-13. PMID: 15963534.
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    100. Jeong JW, Kim TS, Shin DC, Do S, Singh M, Marmarelis VZ. Soft tissue differentiation using multiband signatures of high resolution ultrasonic transmission tomography. IEEE Trans Med Imaging. 2005 Mar; 24(3):399-408. PMID: 15754990.
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    101. Huang C, Marmarelis VZ, Zhou Q, Shung KK. An analytical model of multilayer ultrasonic transducers with an inversion layer. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):469-79. PMID: 15857055.
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    102. Zhou Q, Cannata JM, Guo H, Huang C, Marmarelis VZ, Shung KK. Half-thickness inversion layer high-frequency ultrasonic transducers using LiNbO3 single crystal. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Jan; 52(1):127-33. PMID: 15742569.
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    103. Mitsis GD, Poulin MJ, Robbins PA, Marmarelis VZ. Nonlinear modeling of the dynamic effects of arterial pressure and CO2 variations on cerebral blood flow in healthy humans. IEEE Trans Biomed Eng. 2004 Nov; 51(11):1932-43. PMID: 15536895.
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    104. Gholmieh G, Courellis S, Dimoka A, Wills JD, LaCoss J, Granacki JJ, Marmarelis V, Berger T. An algorithm for real-time extraction of population EPSP and population spike amplitudes from hippocampal field potential recordings. J Neurosci Methods. 2004 Jul 30; 136(2):111-21. PMID: 15183263.
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    105. Song D, Wang Z, Marmarelis VZ, Berger TW. A modeling paradigm incorporating parametric and non-parametric methods. Conf Proc IEEE Eng Med Biol Soc. 2004; 2006:647-50. PMID: 17271760.
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    106. Mitsis GD, Ainslie PN, Poulin MJ, Robbins PA, Marmarelis VZ. Nonlinear modeling of the dynamic effects of arterial pressure and blood gas variations on cerebral blood flow in healthy humans. Adv Exp Med Biol. 2004; 551:259-65. PMID: 15602973.
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    107. Gholmieh G, Courellis S, Fakheri S, Cheung E, Marmarelis V, Baudry M, Berger T. Detection and classification of neurotoxins using a novel short-term plasticity quantification method. Biosens Bioelectron. 2003 Oct 15; 18(12):1467-78. PMID: 12941562.
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    108. Gholmieh G, Courellis S, Marmarelis V, Berger T. An efficient method for studying short-term plasticity with random impulse train stimuli. J Neurosci Methods. 2002 Dec 15; 121(2):111-27. PMID: 12468002.
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    109. Mitsis GD, Zhang R, Levine BD, Marmarelis VZ. Modeling of nonlinear physiological systems with fast and slow dynamics. II. Application to cerebral autoregulation. Ann Biomed Eng. 2002 Apr; 30(4):555-65. PMID: 12086006.
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    110. Mitsis GD, Marmarelis VZ. Modeling of nonlinear physiological systems with fast and slow dynamics. I. Methodology. Ann Biomed Eng. 2002 Feb; 30(2):272-81. PMID: 11962778.
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    111. Gholmieh G, Soussou W, Courellis S, Marmarelis V, Berger T, Baudry M. A biosensor for detecting changes in cognitive processing based on nonlinear systems analysis. Biosens Bioelectron. 2001 Sep; 16(7-8):491-501. PMID: 11544043.
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    112. Shehada RE, Marmarelis VZ, Mansour HN, Grundfest WS. Laser induced fluorescence attenuation spectroscopy: detection of hypoxia. IEEE Trans Biomed Eng. 2000 Mar; 47(3):301-12. PMID: 10743771.
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    113. Alataris K, Berger TW, Marmarelis VZ. A novel network for nonlinear modeling of neural systems with arbitrary point-process inputs. Neural Netw. 2000 Mar; 13(2):255-66. PMID: 10935764.
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    114. Iatrou M, Berger TW, Marmarelis VZ. Application of a novel modeling method to the nonstationary properties of potentiation in the rabbit hippocampus. Ann Biomed Eng. 1999 Sep-Oct; 27(5):581-91. PMID: 10548328.
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    115. Marmarelis VZ, Juusola M, French AS. Principal dynamic mode analysis of nonlinear transduction in a spider mechanoreceptor. Ann Biomed Eng. 1999 May-Jun; 27(3):391-402. PMID: 10374731.
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    116. Iatrou M, Berger TW, Marmarelis VZ. Modeling of nonlinear nonstationary dynamic systems with a novel class of artificial neural networks. IEEE Trans Neural Netw. 1999; 10(2):327-39. PMID: 18252530.
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    117. Marmarelis VZ, Chon KH, Holstein-Rathlou NH, Marsh DJ. Nonlinear analysis of renal autoregulation in rats using principal dynamic modes. Ann Biomed Eng. 1999 Jan-Feb; 27(1):23-31. PMID: 9916757.
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    118. Chon KH, Chen YM, Holstein-Rathlou NH, Marmarelis VZ. Nonlinear system analysis of renal autoregulation in normotensive and hypertensive rats. IEEE Trans Biomed Eng. 1998 Mar; 45(3):342-53. PMID: 9509750.
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    119. Chon KH, Holstein-Rathlou NH, Marsh DJ, Marmarelis VZ. Comparative nonlinear modeling of renal autoregulation in rats: Volterra approach versus artificial neural networks. IEEE Trans Neural Netw. 1998; 9(3):430-5. PMID: 18252466.
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    120. Marmarelis VZ. Modeling methodology for nonlinear physiological systems. Ann Biomed Eng. 1997 Mar-Apr; 25(2):239-51. PMID: 9084829.
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    121. Marmarelis VZ, Zhao X. Volterra models and three-layer perceptrons. IEEE Trans Neural Netw. 1997; 8(6):1421-33. PMID: 18255744.
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    122. Stavridi M, Marmarelis VZ, Grundfest WS. Spectro-temporal studies of Xe-Cl excimer laser-induced arterial wall fluorescence. Med Eng Phys. 1995 Dec; 17(8):595-601. PMID: 8564154.
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    123. French AS, Marmarelis VZ. Nonlinear neuronal mode analysis of action potential encoding in the cockroach tactile spine neuron. Biol Cybern. 1995 Oct; 73(5):425-30. PMID: 7578479.
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    124. Chon KH, Chen YM, Marmarelis VZ, Marsh DJ, Holstein-Rathlou NH. Detection of interactions between myogenic and TGF mechanisms using nonlinear analysis. Am J Physiol. 1994 Jul; 267(1 Pt 2):F160-73. PMID: 8048557.
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    125. Marmarelis VZ, Chon KH, Chen YM, Marsh DJ, Holstein-Rathlou NH. Nonlinear analysis of renal autoregulation under broadband forcing conditions. Ann Biomed Eng. 1993 Nov-Dec; 21(6):591-603. PMID: 8116912.
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    126. Marmarelis VZ, Orme ME. Modeling of neural systems by use of neuronal modes. IEEE Trans Biomed Eng. 1993 Nov; 40(11):1149-58. PMID: 8307599.
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    127. Marmarelis VZ. Identification of nonlinear biological systems using Laguerre expansions of kernels. Ann Biomed Eng. 1993 Nov-Dec; 21(6):573-89. PMID: 8116911.
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    128. Chon KH, Chen YM, Holstein-Rathlou NH, Marsh DJ, Marmarelis VZ. On the efficacy of linear system analysis of renal autoregulation in rats. IEEE Trans Biomed Eng. 1993 Jan; 40(1):8-20. PMID: 8468079.
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    129. Marmarelis VZ. Wiener analysis of nonlinear feedback in sensory systems. Ann Biomed Eng. 1991; 19(4):345-82. PMID: 1741522.
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    130. Papazoglou TG, Papaioannou T, Arakawa K, Fishbein M, Marmarelis VZ, Grundfest WS. Control of excimer laser aided tissue ablation via laser-induced fluorescence monitoring. Appl Opt. 1990 Nov 20; 29(33):4950-5. PMID: 20577490.
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    131. Marmarelis VZ. Signal transformation and coding in neural systems. IEEE Trans Biomed Eng. 1989 Jan; 36(1):15-24. PMID: 2646209.
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    132. Khoo MC, Marmarelis VZ. Estimation of peripheral chemoreflex gain from spontaneous sigh responses. Ann Biomed Eng. 1989; 17(6):557-70. PMID: 2511788.
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    133. Abdel-Malek A, Markham CH, Marmarelis PZ, Marmarelis VZ. Quantifying deficiencies associated with Parkinson's disease by use of time-series analysis. Electroencephalogr Clin Neurophysiol. 1988 Jan; 69(1):24-33. PMID: 2448118.
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    134. Marmarelis VZ. Coherence and apparent transfer function measurements for nonlinear physiological systems. Ann Biomed Eng. 1988; 16(1):143-57. PMID: 3408047.
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    135. Ghazanshahi SD, Yamashiro SM, Marmarelis VZ. Use of a random forcing for high-frequency ventilation. J Appl Physiol (1985). 1987 Mar; 62(3):1201-5. PMID: 3106310.
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    136. Curlander JC, Marmarelis VZ. A linear spatio-temporal model of the light-to-bipolar cell system and its response characteristics to moving bars. Biol Cybern. 1987; 57(6):357-63. PMID: 3435724.
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    137. Citron MC, Marmarelis VZ. Applications of minimum-order Wiener modeling to retinal ganglion cell spatiotemporal dynamics. Biol Cybern. 1987; 57(4-5):241-7. PMID: 3689833.
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    138. Marmarelis VZ, Citron MC, Vivo CP. Minimum-order Wiener modelling of spike-output systems. Biol Cybern. 1986; 54(2):115-23. PMID: 3719030.
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    139. Ghazanshahi SD, Marmarelis VZ, Yamashiro SM. Analysis of the gas exchange system dynamics during high-frequency ventilation. Ann Biomed Eng. 1986; 14(6):525-42. PMID: 3103501.
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    140. Marmarelis VZ. A family of quasi-white random signals and its optimal use in biological system identification. Part I: theory. Biol Cybern. 1977 Jul 08; 27(1):49-56. PMID: 889957.
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    141. Marmarelis VZ, McCann GD. A family of quasi-white random signals and its optimal use in biological system identification. Part II: application to the photoreceptor of Calliphora erythrocephala. Biol Cybern. 1977 Jul 08; 27(1):57-62. PMID: 889958.
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