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Helena Chang Chui, MD

TitleChair and Professor of Neurology
InstitutionUniversity of Southern California
DepartmentNeurology
AddressCHP 215
Health Sciences Campus
Los Angeles CA 90089-9207
Phone+1 323 442 7686
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    Other Positions
    TitleRaymond and Betty McCarron Chair in Neurology


    Collapse Biography 
    Collapse Awards and Honors
    Pasadena Magazine2011Top Doctor

    Collapse Overview 
    Collapse Overview
    Dr. Chui is internationally recognized for her research in Alzheimer disease and vascular cognitive impairment. She is the principal investigator for the NIA-funded Alzheimer Disease Research Center, as well as a multi-institutional program project on vascular dementia.

    Dr. Chui is the author of over 120 publications and has served on the editorial board for Stroke, Alzheimer Disease and Associated Disorders, and Archives of Neurology. She holds the Raymond and Betty McCarron endowed Chair at the Keck School of Medicine and serves as the Chair of the Department of Neurology.


    Collapse Research 
    Collapse Research Activities and Funding
    The Aging Brain: Vasculature, Ischemia, and Behavior
    NIH/NIA P01AG012435Sep 30, 1994 - May 31, 2014
    Role: Principal Investigator
    ALZHEIMER'S DISEASE AND CEREBRAL AMYLOID ANGIOPATHY
    NIH/NIA R01AG007624Jan 1, 1989 - Dec 31, 1994
    Role: Principal Investigator
    Alzheimer Disease Research Center
    NIH/NIA P50AG005142Sep 28, 1984 - Mar 31, 2020
    Role: Principal Investigator
    STUDY SECTION CHAIRMANS FUND (NIH)
    NIH/NIA U09AG005389Aug 15, 1984 - Jul 31, 2005
    Role: Co-Principal Investigator
    HISTOPATHOLOGY OF SENILE DEMENTIA
    NIH/NINDS K07NS000794Jul 1, 1983 - Jun 30, 1988
    Role: Principal Investigator
    Core A Administrative Core
    NIH P50-31
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384. PMID: 28714976.
      View in: PubMed
    2. Parthasarathy V, Frazier DT, Bettcher BM, Jastrzab L, Chao L, Reed B, Mungas D, Weiner M, DeCarli C, Chui H, Kramer JH. Triglycerides are negatively correlated with cognitive function in nondemented aging adults. Neuropsychology. 2017 Sep; 31(6):682-688. PMID: 28604016.
      View in: PubMed
    3. Ramirez-Gomez L, Zheng L, Reed B, Kramer J, Mungas D, Zarow C, Vinters H, Ringman JM, Chui H. Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort. Dement Geriatr Cogn Disord. 2017; 44(1-2):1-11. PMID: 28595184.
      View in: PubMed
    4. Chui H, Ramirez Gomez L. Vascular Contributions to Cognitive Impairment in Late Life. Neurol Clin. 2017 05; 35(2):295-323. PMID: 28410661.
      View in: PubMed
    5. Yassine HN, Braskie MN, Mack WJ, Castor KJ, Fonteh AN, Schneider LS, Harrington MG, Chui H. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review. JAMA Neurol. 2017 Mar 01; 74(3):339-347. PMID: 28114437.
      View in: PubMed
    6. Liu CY, Ohki Y, Tomita T, Osawa S, Reed BR, Jagust W, Van Berlo V, Jin LW, Chui H, Coppola G, Ringman JM. Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease. J Alzheimers Dis. 2017; 58(4):1035-1041. PMID: 28550247.
      View in: PubMed
    7. Lao Y, Nguyen B, Tsao S, Gajawelli N, Law M, Chui H, Weiner M, Wang Y, Leporé N. A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile. Neuroimage Clin. 2017; 14:298-307. PMID: 28210541.
      View in: PubMed
    8. Tso JV, Farinpour R, Chui H, Liu CY. A Multidisciplinary Model of Dementia Care in an Underserved Retirement Community, Made Possible by Telemedicine. Front Neurol. 2016; 7:225. PMID: 28066313.
      View in: PubMed
    9. Casanova R, Wang X, Reyes J, Akita Y, Serre ML, Vizuete W, Chui H, Driscoll I, Resnick SM, Espeland MA, Chen JC. A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women. Front Hum Neurosci. 2016; 10:495. PMID: 27790103.
      View in: PubMed
    10. Yassine HN, Feng Q, Azizkhanian I, Rawat V, Castor K, Fonteh AN, Harrington MG, Zheng L, Reed BR, DeCarli C, Jagust WJ, Chui H. Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis. JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. PMID: 27532692.
      View in: PubMed
    11. Besser LM, Alosco ML, Ramirez Gomez L, Zhou XH, McKee AC, Stern RA, Gunstad J, Schneider JA, Chui H, Kukull WA. Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition. J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962. PMID: 27516116.
      View in: PubMed
    12. Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui H, Schneider LS. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimers Res Ther. 2016 Jun 30; 8:25. PMID: 27358067; PMCID: PMC4928349.
    13. Yassine HN, Feng Q, Chiang J, Petrosspour LM, Fonteh AN, Chui H, Harrington MG. ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Am Heart Assoc. 2016 Feb 12; 5(2). PMID: 26873692; PMCID: PMC4802440.
    14. Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui H, Hachinski V. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. PMID: 26198175; PMCID: PMC4758552 [Available on 01/01/17].
    15. Zheng L, Vinters HV, Mack WJ, Weiner MW, Chui H. Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition. J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. PMID: 26126864; PMCID: PMC4758550 [Available on 01/01/17].
    16. La Morgia C, Ross-Cisneros FN, Koronyo Y, Hannibal J, Gallassi R, Cantalupo G, Sambati L, Pan BX, Tozer KR, Barboni P, Provini F, Avanzini P, Carbonelli M, Pelosi A, Chui H, Liguori R, Baruzzi A, Koronyo-Hamaoui M, Sadun AA, Carelli V. Melanopsin retinal ganglion cell loss in Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):90-109. PMID: 26505992; PMCID: PMC4737313.
    17. Chui H, Gerstorf D, Hoppmann CA, Luszcz MA. Trajectories of depressive symptoms in old age: Integrating age-, pathology-, and mortality-related changes. Psychol Aging. 2015 Dec; 30(4):940-51. PMID: 26502093.
      View in: PubMed
    18. Chen JC, Wang X, Wellenius GA, Serre ML, Driscoll I, Casanova R, McArdle JJ, Manson JE, Chui H, Espeland MA. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study. Ann Neurol. 2015 Sep; 78(3):466-76. PMID: 26075655; PMCID: PMC4546504.
    19. Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, Haase CM, Miller J, Poon WW, Rosen A, Rosen H, Sapozhnikova A, Shapira J, Varpetian A, Foroud TM, Levenson RW, Levey AI, Kukull WA, Mendez MF, Ringman J, Chui H, Cotman C, DeCarli C, Miller BL, Geschwind DH, Coppola G. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. JAMA Neurol. 2015 Apr; 72(4):414-22. PMID: 25706306; PMCID: PMC4397175.
    20. Chui H, Ramirez-Gomez L. Clinical and imaging features of mixed Alzheimer and vascular pathologies. Alzheimers Res Ther. 2015; 7(1):21. PMID: 25722748; PMCID: PMC4342006.
    21. Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Rogaeva E. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16. PMID: 25531812.
      View in: PubMed
    22. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui H, Law M, Zlokovic BV. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. PMID: 25611508; PMCID: PMC4350773.
    23. Frazier DT, Seider T, Bettcher BM, Mack WJ, Jastrzab L, Chao L, Weiner MW, DeCarli C, Reed BR, Mungas D, Chui H, Kramer JH. The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort. Cerebrovasc Dis. 2014; 38(6):441-7. PMID: 25502351; PMCID: PMC4303029.
    24. Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, Baldwin CT, Jarvik GP, Crane PK, Rogaeva E, Barmada MM, Demirci FY, Cruchaga C, Kramer PL, Ertekin-Taner N, Hardy J, Graff-Radford NR, Green RC, Larson EB, St George-Hyslop PH, Buxbaum JD, Evans DA, Schneider JA, Lunetta KL, Kamboh MI, Saykin AJ, Reiman EM, De Jager PL, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Martin ER, Haines JL, Mayeux RP, Farrer LA, Schellenberg GD, Pericak-Vance MA. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404. PMID: 25199842.
      View in: PubMed
    25. Hajjar I, Marmerelis V, Shin DC, Chui H. Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension. Cerebrovasc Dis. 2014; 38(1):10-6. PMID: 25171390; PMCID: PMC4216224.
    26. Brothers A, Chui H, Diehl M. Measuring future time perspective across adulthood: development and evaluation of a brief multidimensional questionnaire. Gerontologist. 2014 Dec; 54(6):1075-88. PMID: 25063938; PMCID: PMC4296169.
    27. Sachdev P, Kalaria R, O'Brien J, Skoog I, Alladi S, Black SE, Blacker D, Blazer DG, Chen C, Chui H, Ganguli M, Jellinger K, Jeste DV, Pasquier F, Paulsen J, Prins N, Rockwood K, Roman G, Scheltens P. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):206-18. PMID: 24632990; PMCID: PMC4139434.
    28. Villeneuve S, Reed BR, Madison CM, Wirth M, Marchant NL, Kriger S, Mack WJ, Sanossian N, DeCarli C, Chui H, Weiner MW, Jagust WJ. Vascular risk and Aß interact to reduce cortical thickness in AD vulnerable brain regions. Neurology. 2014 Jul 01; 83(1):40-7. PMID: 24907234; PMCID: PMC4114172.
    29. Tsao S, Gajawelli N, Hwang DH, Kriger S, Law M, Chui H, Weiner M, Lepore N. Mapping of ApoE4 Related White Matter Damage using Diffusion MRI. Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390H. PMID: 25076830.
      View in: PubMed
    30. Tsao S, Ma SJ, Michels PA, Gajawelli N, Law M, Chui H, Lepore N. The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR. Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390I. PMID: 25076831.
      View in: PubMed
    31. Reed B, Villeneuve S, Mack W, DeCarli C, Chui H, Jagust W. Associations between serum cholesterol levels and cerebral amyloidosis. JAMA Neurol. 2014 Feb; 71(2):195-200. PMID: 24378418; PMCID: PMC4083819.
    32. Villeneuve S, Reed BR, Wirth M, Haase CM, Madison CM, Ayakta N, Mack W, Mungas D, Chui H, DeCarli C, Weiner MW, Jagust WJ. Cortical thickness mediates the effect of ß-amyloid on episodic memory. Neurology. 2014 Mar 04; 82(9):761-7. PMID: 24489134; PMCID: PMC3945649.
    33. Lee JY, Park S, Mackin S, Ewers M, Chui H, Jagust W, Insel PS, Weiner MW. Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression. PLoS One. 2014; 9(1):e87747. PMID: 24498184; PMCID: PMC3909227.
    34. Lyness SA, Lee AY, Zarow C, Teng EL, Chui H. 10-minute delayed recall from the modified mini-mental state test predicts Alzheimer's disease pathology. J Alzheimers Dis. 2014; 39(3):575-82. PMID: 24240637; PMCID: PMC4220788.
    35. Rannikmäe K, Kalaria RN, Greenberg SM, Chui H, Schmitt FA, Samarasekera N, Al-Shahi Salman R, Sudlow CL. APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis. J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):300-5. PMID: 24163429; PMCID: PMC4018226.
    36. Zheng L, Vinters HV, Mack WJ, Zarow C, Ellis WG, Chui H. Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes. Stroke. 2013 Oct; 44(10):2835-41. PMID: 23887837; PMCID: PMC4049465.
    37. Diehl M, Chui H, Hay EL, Lumley MA, Grühn D, Labouvie-Vief G. Change in coping and defense mechanisms across adulthood: longitudinal findings in a European American sample. Dev Psychol. 2014 Feb; 50(2):634-48. PMID: 23834293; PMCID: PMC3936469.
    38. Chao LL, Decarli C, Kriger S, Truran D, Zhang Y, Laxamana J, Villeneuve S, Jagust WJ, Sanossian N, Mack WJ, Chui H, Weiner MW. Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI. PLoS One. 2013; 8(6):e65175. PMID: 23762308.
      View in: PubMed
    39. Marchant NL, Reed BR, Sanossian N, Madison CM, Kriger S, Dhada R, Mack WJ, DeCarli C, Weiner MW, Mungas DM, Chui H, Jagust WJ. The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction. JAMA Neurol. 2013 Apr; 70(4):488-95. PMID: 23400560; PMCID: PMC3771392.
    40. Hajjar I, Brown L, Mack WJ, Chui H. Alzheimer pathology and angiotension receptor blockers. JAMA Neurol. 2013 Mar 01; 70(3):414. PMID: 23478841.
      View in: PubMed
    41. Hajjar I, Brown L, Mack WJ, Chui H. Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series. Arch Neurol. 2012 Dec; 69(12):1632-8. PMID: 22964777; PMCID: PMC3608189.
    42. Cardenas VA, Reed B, Chao LL, Chui H, Sanossian N, DeCarli CC, Mack W, Kramer J, Hodis HN, Yan M, Buonocore MH, Carmichael O, Jagust WJ, Weiner MW. Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults. Stroke. 2012 Nov; 43(11):2865-70. PMID: 22984010; PMCID: PMC3732460.
    43. Lee JY, Insel P, Mackin RS, Schuff N, Chui H, DeCarli C, Park KH, Mueller SG, Weiner MW. Different associations of white matter lesions with depression and cognition. BMC Neurol. 2012 Aug 25; 12:83. PMID: 22920586; PMCID: PMC3482604.
    44. Zheng L, Teng EL, Varma R, Mack WJ, Mungas D, Lu PH, Chui H. Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects. Int J Alzheimers Dis. 2012; 2012:204623. PMID: 22830073; PMCID: PMC3399373.
    45. Jung S, Zarow C, Mack WJ, Zheng L, Vinters HV, Ellis WG, Lyness SA, Chui H. Preservation of neurons of the nucleus basalis in subcortical ischemic vascular disease. Arch Neurol. 2012 Jul; 69(7):879-86. PMID: 22393167; PMCID: PMC4184885.
    46. Zarow C, Weiner MW, Ellis WG, Chui H. Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample. Brain Behav. 2012 Jul; 2(4):435-42. PMID: 22950047; PMCID: PMC3432966.
    47. Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Schultz D, Rakhshan F, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8. PMID: 22722634.
      View in: PubMed
    48. Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, Cotman CW, Decarli CS, Levey AI, Ringman JM, Mendez MF, Chui H, Le Ber I, Brice A, Lupton MK, Preza E, Lovestone S, Powell J, Graff-Radford N, Petersen RC, Boeve BF, Lippa CF, Bigio EH, Mackenzie I, Finger E, Kertesz A, Caselli RJ, Gearing M, Juncos JL, Ghetti B, Spina S, Bordelon YM, Tourtellotte WW, Frosch MP, Vonsattel JP, Zarow C, Beach TG, Albin RL, Lieberman AP, Lee VM, Trojanowski JQ, Van Deerlin VM, Bird TD, Galasko DR, Masliah E, White CL, Troncoso JC, Hannequin D, Boxer AL, Geschwind MD, Kumar S, Mandelkow EM, Wszolek ZK, Uitti RJ, Dickson DW, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. PMID: 22556362.
      View in: PubMed
    49. Hajjar I, Hart M, Chen YL, Mack W, Milberg W, Chui H, Lipsitz L. Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial. Arch Intern Med. 2012 Mar 12; 172(5):442-4. PMID: 22412114; PMCID: PMC3536822.
    50. Zheng L, Mack WJ, Chui H, Heflin L, Mungas D, Reed B, DeCarli C, Weiner MW, Kramer JH. Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults. J Am Geriatr Soc. 2012 Mar; 60(3):499-504. PMID: 22283410; PMCID: PMC3302932.
    51. Chui H, Zheng L, Reed BR, Vinters HV, Mack WJ. Vascular risk factors and Alzheimer's disease: are these risk factors for plaques and tangles or for concomitant vascular pathology that increases the likelihood of dementia? An evidence-based review. Alzheimers Res Ther. 2012 Jan 04; 4(1):1. PMID: 22182734; PMCID: PMC3471388.
    52. Reed BR, Marchant NL, Jagust WJ, DeCarli CC, Mack W, Chui H. Coronary risk correlates with cerebral amyloid deposition. Neurobiol Aging. 2012 Sep; 33(9):1979-87. PMID: 22078485; PMCID: PMC3371309.
    53. Marchant NL, Reed BR, DeCarli CS, Madison CM, Weiner MW, Chui H, Jagust WJ. Cerebrovascular disease, ß-amyloid, and cognition in aging. Neurobiol Aging. 2012 May; 33(5):1006.e25-36. PMID: 22048124; PMCID: PMC3274647.
    54. Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui H, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep; 42(9):2672-713. PMID: 21778438; PMCID: PMC3778669.
    55. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui H, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41. PMID: 21460841.
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