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Hussein Yassine, MD

Title(s)Associate Professor of Medicine
AddressCSC 210
Health Sciences Campus
Los Angeles CA 90089-9073
Phone+1 323 442 1909
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    Collapse Biography 
    Collapse Awards and Honors
    Beirut Arab University, Beirut, Lebanon 2002Dean's Distinguished Student Medicine Day Award
    Beirut Arab University, Beirut, Lebanon 2003Dean's Honor List on graduation
    Case Western Reserve University, Cleveland, OH 2007Resident Teacher of the Year Award
    2009Department of Veterans Affairs VISN 18 Outstanding Research Award
    2009Presidential Poster Award, Endocrine Society

    Collapse Overview 
    Collapse Overview
    Dr. Yassine is an Associate Professor in the Department of Medicine, Keck School of Medicine of USC.

    The Yassine lab (www.yassinelab.com) specializes in how changes in lipid metabolism and nutrition affect cognition and the risk of developing Alzheimer's disease (AD). The lab has an interest in studying how carrying the APOE4 allele, strongest genetic risk factors for developing AD, affects lipid metabolism, the response to the diet; combining basic science, clinical trials and brain imaging studies.

    Dr. Yassine directs the Roybal AD Research program focused on understanding how obesity, diabetes and vascular risk factors in Los Angeles’s Latinx population affect cognition and AD risk using longitudinal studies with cerebrospinal fluid and brain imaging biomarkers.

    Dr. Yassine runs the Lipid Clinic at Roybal Healthcare Center in East LA, providing care for a large population of complex lipid and diabetes disorders that are referred from all LA county clinics.

    Collapse Research 
    Collapse Research Activities and Funding
    A Symposium on Nutrition State of Science for Dementia Prevention
    NIH/NIA R13AG069386Aug 15, 2020 - Jul 31, 2021
    Role: Principal Investigator
    ApoE, ABCA1 and endosomal dysregulation in AD
    NIH/NIA R01AG067063May 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    DHA brain delivery by APOE genotype
    NIH/NIA R21AG056518May 15, 2018 - Jan 31, 2020
    Role: Principal Investigator
    The delivery of essential fatty acids to the Brain in Alzheimer's disease
    NIH/NIA R01AG054434Sep 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Biomarkers of ABCA1 mediated functions in Alzheimers disease
    NIH/NIA R01AG055770Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    The Effect of Saturated Fat Ingestion on the HDL Proteome
    NIH/NHLBI K23HL107389May 15, 2012 - Apr 30, 2017
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine. 2020 Sep; 59:102883. Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. PMID: 32690472.
      View in: PubMed   Mentions: 1     Fields:    
    2. APOE Alleles and Diet in Brain Aging and Alzheimer's Disease. Front Aging Neurosci. 2020; 12:150. Yassine HN, Finch CE. PMID: 32587511.
      View in: PubMed   Mentions:
    3. Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus? Neurobiol Aging. 2020 08; 92:61-72. Yassine HN, Anderson A, Brinton R, Carmichael O, Espeland MA, Hoscheidt S, Hugenschmidt CE, Keller JN, Peters A, Pi-Sunyer X. PMID: 32388179.
      View in: PubMed   Mentions: 1     Fields:    
    4. Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2020 Mar 09; 75(4):771-778. Espeland MA, Hayden KM, Lockhart SN, Yassine HN, Hoscheidt S, Yasar S, Luchsinger JA, Neiberg RH, Diaz Brinton R, Carmichael O. PMID: 30997482.
      View in: PubMed   Mentions:    Fields:    
    5. Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial. J Alzheimers Dis. 2020; 74(3):975-990. Tomaszewski N, He X, Solomon V, Lee M, Mack WJ, Quinn JF, Braskie MN, Yassine HN. PMID: 32116250.
      View in: PubMed   Mentions: 1     Fields:    
    6. Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid. J Alzheimers Dis. 2020; 76(3):883-893. Hu Y, Meuret C, Go S, Yassine HN, Nedelkov D. PMID: 32568201.
      View in: PubMed   Mentions: 1     Fields:    
    7. ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes. J Neurosci. 2019 11 27; 39(48):9611-9622. Rawat V, Wang S, Sima J, Bar R, Liraz O, Gundimeda U, Parekh T, Chan J, Johansson JO, Tang C, Chui HC, Harrington MG, Michaelson DM, Yassine HN. PMID: 31641056.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    8. ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2145-2156. Kegulian NC, Ramms B, Horton S, Trenchevska O, Nedelkov D, Graham MJ, Lee RG, Esko JD, Yassine HN, Gordts PLSM. PMID: 31390883.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    9. Development of a delayed-release nutrient for appetite control in adults with obesity and type 2 diabetes and initial clinical testing in a single dose randomized controlled trial. Nutr Diabetes. 2019 07 15; 9(1):20. Beale E, Lim E, Yassine H, Azen C, Christopher C. PMID: 31308360.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis. J Alzheimers Dis. 2019; 68(3):983-990. Lee S, Parekh T, King SM, Reed B, Chui HC, Krauss RM, Yassine HN. PMID: 30883362.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Targeting prodromal Alzheimer's disease: too late for prevention? Lancet Neurol. 2017 12; 16(12):946-947. Yassine HN. PMID: 29097165.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Ex vivo instability of glycated albumin: A role for autoxidative glycation. Arch Biochem Biophys. 2017 09 01; 629:36-42. Jeffs JW, Ferdosi S, Yassine HN, Borges CR. PMID: 28712850.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Lessons from the Multidomain Alzheimer Preventive Trial. Lancet Neurol. 2017 08; 16(8):585-586. Yassine HN, Schneider LS. PMID: 28721922.
      View in: PubMed   Mentions: 1     Fields:    
    14. DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA. Alzheimers Res Ther. 2017 Mar 23; 9(1):23. Yassine HN, Croteau E, Rawat V, Hibbeln JR, Rapoport SI, Cunnane SC, Umhau JC. PMID: 28335828.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review. JAMA Neurol. 2017 Mar 01; 74(3):339-347. Yassine HN, Braskie MN, Mack WJ, Castor KJ, Fonteh AN, Schneider LS, Harrington MG, Chui HC. PMID: 28114437.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    16. Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions. J Clin Lipidol. 2017 Jan - Feb; 11(1):224-233.e2. Mendoza S, Trenchevska O, King SM, Nelson RW, Nedelkov D, Krauss RM, Yassine HN. PMID: 28391889.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    17. Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis. JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. Yassine HN, Feng Q, Azizkhanian I, Rawat V, Castor K, Fonteh AN, Harrington MG, Zheng L, Reed BR, DeCarli C, Jagust WJ, Chui HC. PMID: 27532692.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    18. Development of quantitative mass spectrometric immunoassay for serum amyloid A. Biomarkers. 2016 Dec; 21(8):743-751. Trenchevska O, Yassine HN, Borges CR, Nelson RW, Nedelkov D. PMID: 27308834.
      View in: PubMed   Mentions: 1     Fields:    
    19. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimers Res Ther. 2016 06 30; 8:25. Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. PMID: 27358067.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    20. The association of plasma cystatin C proteoforms with diabetic chronic kidney disease. Proteome Sci. 2016; 14:7. Yassine HN, Trenchevska O, Dong Z, Bashawri Y, Koska J, Reaven PD, Nelson RW, Nedelkov D. PMID: 27019641.
      View in: PubMed   Mentions:
    21. Posttranslational modifications of apolipoprotein A-II proteoforms in type 2 diabetes. J Clin Lipidol. 2016 Jul-Aug; 10(4):808-815. Azizkhanian I, Trenchevska O, Bashawri Y, Hu J, Koska J, Reaven PD, Nelson RW, Nedelkov D, Yassine HN. PMID: 27578111.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    22. Disialylated apolipoprotein C-III proteoform is associated with improved lipids in prediabetes and type 2 diabetes. J Lipid Res. 2016 05; 57(5):894-905. Koska J, Yassine H, Trenchevska O, Sinari S, Schwenke DC, Yen FT, Billheimer D, Nelson RW, Nedelkov D, Reaven PD. PMID: 26945091.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Am Heart Assoc. 2016 Feb 12; 5(2). Yassine HN, Feng Q, Chiang J, Petrosspour LM, Fonteh AN, Chui HC, Harrington MG. PMID: 26873692.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    24. The Association of Human Apolipoprotein C-III Sialylation Proteoforms with Plasma Triglycerides. PLoS One. 2015; 10(12):e0144138. Yassine HN, Trenchevska O, Ramrakhiani A, Parekh A, Koska J, Walker RW, Billheimer D, Reaven PD, Yen FT, Nelson RW, Goran MI, Nedelkov D. PMID: 26633899.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    25. Site specific modification of the human plasma proteome by methylglyoxal. Toxicol Appl Pharmacol. 2015 Dec 01; 289(2):155-62. Kimzey MJ, Kinsky OR, Yassine HN, Tsaprailis G, Stump CS, Monks TJ, Lau SS. PMID: 26435215.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    26. Serum amyloid a truncations in type 2 diabetes mellitus. PLoS One. 2015; 10(1):e0115320. Yassine HN, Trenchevska O, He H, Borges CR, Nedelkov D, Mack W, Kono N, Koska J, Reaven PD, Nelson RW. PMID: 25607823.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    27. The Application of Multiple Reaction Monitoring to Assess Apo A-I Methionine Oxidations in Diabetes and Cardiovascular Disease. Transl Proteom. 2014 Dec 01; 4-5:18-24. Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH. PMID: 25705587.
      View in: PubMed   Mentions:
    28. Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions. Mol Cell Proteomics. 2014 Jul; 13(7):1890-9. Borges CR, Rehder DS, Jensen S, Schaab MR, Sherma ND, Yassine H, Nikolova B, Breburda C. PMID: 24736286.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    29. Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes. Metabolism. 2014 May; 63(5):727-34. Yassine HN, Belopolskaya A, Schall C, Stump CS, Lau SS, Reaven PD. PMID: 24636347.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    30. The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins. Lipids Health Dis. 2014 Jan 08; 13:8. Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH. PMID: 24397693.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    31. Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: potential applications to cardiovascular disease and diabetes. Proteomics Clin Appl. 2013 Aug; 7(7-8):528-40. Yassine H, Borges CR, Schaab MR, Billheimer D, Stump C, Reaven P, Lau SS, Nelson R. PMID: 23696124.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    32. Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade. Endocr Pract. 2012 Sep-Oct; 18(5):e111-3. Kastoon T, Stump CS, Thomson SP, Yassine H. PMID: 22440982.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Adjusting for Urinary Creatinine Overestimates Arsenic Concentrations in Diabetics. Cardiorenal Med. 2012 Feb; 2(1):26-32. Yassine H, Kimzey MJ, Galligan MA, Gandolfi AJ, Stump CS, Lau SS. PMID: 22493600.
      View in: PubMed   Mentions: 9     Fields:    
    34. Effect of glucose or fat challenge on aspirin resistance in diabetes. Int J Endocrinol. 2010; 2010:820876. Yassine HN, Davis-Gorman G, Stump CS, Thomson SS, Peterson J, McDonagh PF. PMID: 21318184.
      View in: PubMed   Mentions:
    35. New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chem Biol Interact. 2011 Jun 30; 192(1-2):122-8. Kimzey MJ, Yassine HN, Riepel BM, Tsaprailis G, Monks TJ, Lau SS. PMID: 20934417.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    36. Clinical determinants of aspirin resistance in diabetes. Diabetes Res Clin Pract. 2010 Oct; 90(1):e19-21. Yassine HN, Davis-Gorman G, Stump CS, Thomson SS, Peterson J, McDonagh PF. PMID: 20719400.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):90-5. Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. PMID: 19164269.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
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