Hussein Yassine, MD

Title(s)Professor of Neurology and Department of Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
AddressCSC 210
Health Sciences Campus
Los Angeles CA 90089-9073
Phone+1 323 442 1909
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    Other Positions
    Title(s)Kenneth and Bette Volk Professorship in Neurology

    Title(s)Director, Center for Personalized Brain Health


    Collapse Biography 
    Collapse awards and honors
    Beirut Arab University, Beirut, Lebanon 2002Dean's Distinguished Student Medicine Day Award
    Beirut Arab University, Beirut, Lebanon 2003Dean's Honor List on graduation
    Case Western Reserve University, Cleveland, OH 2007Resident Teacher of the Year Award
    2009Department of Veterans Affairs VISN 18 Outstanding Research Award
    2009Presidential Poster Award, Endocrine Society

    Collapse Overview 
    Collapse overview
    Dr. Yassine is the Volke Endowed Professor of Neurology at Keck School of Medicine of USC.

    The Yassine lab specializes in how lipid metabolism and nutrition changes affect cognition and the risk of developing late-onset Alzheimer's disease (AD). The lab is interested in studying how carrying the APOE4 allele, the strongest genetic risk factor for developing AD, affects lipid metabolism, neuroinflammation, and the response to the diet; combining basic science, clinical trials, and brain imaging studies.

    Dr. Yassine directs the USC Center for Personalized Brain Health (https://keck.usc.edu/cpbh/) focused on understanding mechanisms and risk factors of dementia in patients carrying the APOE4 allele.
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    Collapse Research 
    Collapse research activities and funding
    A Symposium on Nutrition State of Science for Dementia Prevention
    NIH R13AG069386Aug 15, 2020 - Jul 31, 2021
    Role: Principal Investigator
    ApoE, ABCA1 and endosomal dysregulation in AD
    NIH R01AG067063May 15, 2020 - Feb 28, 2025
    Role: Principal Investigator
    DHA brain delivery by APOE genotype
    NIH R21AG056518May 15, 2018 - Jan 31, 2021
    Role: Principal Investigator
    The delivery of essential fatty acids to the Brain in Alzheimer's disease
    NIH R01AG054434Sep 1, 2017 - Apr 30, 2022
    Role: Principal Investigator
    Biomarkers of ABCA1 mediated functions in Alzheimers disease
    NIH R01AG055770Jun 1, 2017 - May 31, 2022
    Role: Principal Investigator
    The Effect of Saturated Fat Ingestion on the HDL Proteome
    NIH K23HL107389May 15, 2012 - Apr 30, 2018
    Role: Principal Investigator

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    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. High precision and cost-effective multiplex quantification of amyloid-β40, amyloid-β42, p181Tau, p217Tau, neurofilament light chain, and glial fibrillary acidic protein from plasma and serum. J Alzheimers Dis. 2025 May 13; 13872877251340999. Alishahi F, Beam CR, Gatz M, Schneider LS, Nation DA, Yassine HN, Kaplan H, Ganesan S, Pappas I, Davis DW, Zandi E. PMID: 40356374.
      View in: PubMed   Mentions:    Fields:    
    2. Cerebral hypoperfusion, brain structural integrity, and cognitive impairment in older APOE4 carriers. Geroscience. 2025 Apr 12. Pappas I, Lohman T, Dutt S, Kapoor A, Engstrom AC, Alitin JPM, Barnes S, Chakhoyan A, Saca L, Gaggar R, Nourollahimoghadam E, Wang DJJ, Lai MHC, Joe EB, Ringman JM, Yassine HN, Schneider LS, Chui HC, Toga AW, Zlokovic BV, Nation DA. PMID: 40220152.
      View in: PubMed   Mentions:    Fields:    
    3. Evidence for cPLA2 activation in Alzheimer's Disease Synaptic Pathology. bioRxiv. 2025 Apr 01. Ma QL, Ebright B, Li B, Li J, Galvan J, Sanchez A, Renteln M, Dikeman D, Wang S, Kerman BE, Seidler P, Gutierrez-Grebenkova B, Hjelm BE, Hawes D, Hiniker AE, Hurth KM, Bennett DA, Louie SG, Chui HC, Limon A, Arvanitakis Z, Yassine HN. PMID: 40236242; PMCID: PMC11996316.
      View in: PubMed   Mentions:
    4. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD. Mol Neurodegener. 2025 Feb 04; 20(1):15. Wang S, Li B, Li J, Cai Z, Hugo C, Sun Y, Qian L, Tcw J, Chui HC, Dikeman D, Asante I, Louie SG, Bennett DA, Arvanitakis Z, Remaley AT, Kerman BE, Yassine HN. PMID: 39901180; PMCID: PMC11792374.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer's disease biomarkers. bioRxiv. 2024 Dec 21. Nedelkov D, Tsokolas ZE, Rodrigues MS, Sible I, Han SD, Kerman BE, Renteln M, Mack WJ, Pascoal TA, Yassine HN, Alzheimer’s Disease Neuroimaging Initiative. PMID: 39763949; PMCID: PMC11702616.
      View in: PubMed   Mentions:
    6. Development of Calcium-Dependent Phospholipase A2 Inhibitors to Target Cellular Senescence and Oxidative Stress in Neurodegenerative Diseases. Antioxid Redox Signal. 2024 Dec; 41(16-18):1100-1116. Hugo C, Asante I, Sadybekov A, Katritch V, Yassine HN. PMID: 39575710.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    7. Microglia States are Susceptible to Senescence and Cholesterol Dysregulation in Alzheimer's Disease. bioRxiv. 2024 Nov 18. Li B, Wang S, Kerman B, Hugo C, Shwab EK, Shu C, Chiba-Falek O, Arvanitakis Z, Yassine H. PMID: 39605544; PMCID: PMC11601396.
      View in: PubMed   Mentions:
    8. APOE ε4 and Dietary Patterns in Relation to Cognitive Function: An Umbrella Review of Systematic Reviews. Nutr Rev. 2024 Nov 05. Urich TJ, Tsiknia AA, Ali N, Park J, Mack WJ, Cortessis VK, Dinalo JE, Yassine HN. PMID: 39499795.
      View in: PubMed   Mentions:    Fields:    
    9. Lower entorhinal cortex thickness is associated with greater financial exploitation vulnerability in cognitively unimpaired older adults. Cereb Cortex. 2024 09 03; 34(9). Fenton L, Salminen LE, Lim AC, Weissberger GH, Nguyen AL, Axelrod J, Noriega-Makarskyy D, Yassine H, Mosqueda L, Han SD. PMID: 39227308; PMCID: PMC11371417.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer's Disease. Aging Dis. 2024 Aug 01; 15(4):1688-1725. Rhea EM, Leclerc M, Yassine HN, Capuano AW, Tong H, Petyuk VA, Macauley SL, Fioramonti X, Carmichael O, Calon F, Arvanitakis Z. PMID: 37611907; PMCID: PMC11272209.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    11. Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. Alzheimers Dement. 2024 Sep; 20(9):6590-6605. Kloske CM, Belloy ME, Blue EE, Bowman GR, Carrillo MC, Chen X, Chiba-Falek O, Davis AA, Paolo GD, Garretti F, Gate D, Golden LR, Heinecke JW, Herz J, Huang Y, Iadecola C, Johnson LA, Kanekiyo T, Karch CM, Khvorova A, Koppes-den Hertog SJ, Lamb BT, Lawler PE, Guen YL, Litvinchuk A, Liu CC, Mahinrad S, Marcora E, Marino C, Michaelson DM, Miller JJ, Morganti JM, Narayan PS, Naslavsky MS, Oosthoek M, Ramachandran KV, Ramakrishnan A, Raulin AC, Robert A, Saleh RNM, Sexton C, Shah N, Shue F, Sible IJ, Soranno A, Strickland MR, Tcw J, Thierry M, Tsai LH, Tuckey RA, Ulrich JD, van der Kant R, Wang N, Wellington CL, Weninger SC, Yassine HN, Zhao N, Bu G, Goate AM, Holtzman DM. PMID: 39031528; PMCID: PMC11497726.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    12. Cellular senescence induced by cholesterol accumulation is mediated by lysosomal ABCA1 in APOE4 and AD. Res Sq. 2024 May 14. Wang S, Li B, Cai Z, Hugo C, Li J, Sun Y, Qian L, Remaley AT, Tcw J, Chui HC, Bennett DA, Arvanitakis Z, Kerman B, Yassine H. PMID: 38798644; PMCID: PMC11118681.
      View in: PubMed   Mentions:
    13. Sex Specific Associations of Sex hormone With Brain Volumes and Cerebral Blood Flow: A Cross Sectional Observational Study Within the Look AHEAD Type 2 Diabetes Cohort. Res Sq. 2024 Apr 29. Vaidya D, Yeboah-Kordieh Y, Howard M, Hugenschmidt CE, Nyquist PA, Michos ED, Kalyani RR, Yasar S, Robusto BA, Yassine HN, Clark JM, Espeland MA, Bennett WL. PMID: 38746210; PMCID: PMC11092849.
      View in: PubMed   Mentions:
    14. Effects of APOE4 on omega-3 brain metabolism across the lifespan. Trends Endocrinol Metab. 2024 Aug; 35(8):745-757. Ebright B, Duro MV, Chen K, Louie S, Yassine HN. PMID: 38609814; PMCID: PMC11321946.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    15. Designing Newer Omega-3 Supplementation Trials for Cognitive Outcomes: A Systematic Review Guided Analysis. J Alzheimers Dis. 2024; 101(s1):S455-S466. Yassine HN, Carrasco AS, Badie DS. PMID: 39422948.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Can the gut microbiome inform the effects of omega-3 fatty acid supplementation trials on cognition? Curr Opin Clin Nutr Metab Care. 2024 03 01; 27(2):116-124. Kerman BE, Self W, Yassine HN. PMID: 38170690; PMCID: PMC10872319.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    17. Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics. ACS Chem Neurosci. 2023 12 20; 14(24):4409-4418. Duro MVV, Van Valkenburgh J, Ingles DE, Tran J, Cai Z, Ebright B, Wang S, Kerman BE, Galvan J, Hwang SH, Sta Maria NS, Zanderigo F, Croteau E, Cunnane SC, Rapoport SI, Louie SG, Jacobs RE, Yassine HN, Chen K. PMID: 38048230; PMCID: PMC10739598.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    18. The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions. bioRxiv. 2023 Jul 13. Nandana V, Rathnayaka-Mudiyanselage IW, Muthunayak NS, Hatami A, Mousseau CB, Ortiz-Rodríguez LA, Vaishnav J, Collins M, Gega A, Mallikaarachchi KS, Yassine H, Ghosh A, Biteen JS, Zhu Y, Champion MM, Childers WS, Schrader JM. PMID: 36712072; PMCID: PMC9882336.
      View in: PubMed   Mentions:
    19. An association of CSF apolipoprotein E glycosylation and amyloid-beta 42 in individuals who carry the APOE4 allele. Alzheimers Res Ther. 2023 05 23; 15(1):96. Meuret CJ, Hu Y, Smadi S, Bantugan MA, Xian H, Martinez AE, Krauss RM, Ma QL, Nedelkov D, Yassine HN. PMID: 37221560; PMCID: PMC10204298.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    20. Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness. J Lipid Res. 2023 06; 64(6):100354. Bantugan MA, Xian H, Solomon V, Lee M, Cai Z, Wang S, Duro MV, Kerman BE, Fonteh A, Meuret C, Li M, Braskie MN, McIntire LBJ, Jurin L, Oberlin S, Evans J, Davis R, Mack WJ, Abdullah L, Yassine HN. PMID: 36958720; PMCID: PMC10230261.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    21. Baseline Findings of PreventE4: A Double-Blind Placebo Controlled Clinical Trial Testing High Dose DHA in APOE4 Carriers before the Onset of Dementia. J Prev Alzheimers Dis. 2023; 10(4):810-820. Yassine HN, Arellanes IC, Mazmanian A, De La Cruz L, Martinez J, Contreras L, Kono N, Liu BS, Badie D, Bantugan MA, Grindon A, Urich T, D'Orazio L, Emmanuel BA, Chui HC, Mack WJ, Harrington MG, Braskie MN, Schneider LS. PMID: 37874103.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. The omega-3 index in Alzheimer's disease: Ready for prime time? Am J Clin Nutr. 2022 12 19; 116(6):1474-1475. Yassine HN. PMID: 36253954; PMCID: PMC9761771.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    23. Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias. Alzheimers Dement. 2023 03; 19(3):1041-1066. Yassine HN, Self W, Kerman BE, Santoni G, Navalpur Shanmugam N, Abdullah L, Golden LR, Fonteh AN, Harrington MG, Gräff J, Gibson GE, Kalaria R, Luchsinger JA, Feldman HH, Swerdlow RH, Johnson LA, Albensi BC, Zlokovic BV, Tanzi R, Cunnane S, Samieri C, Scarmeas N, Bowman GL. PMID: 36479795; PMCID: PMC10576546.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    24. APOE alleles modulate associations of plasma metabolites with variants from multiple genes on chromosome 19q13.3. Front Aging Neurosci. 2022; 14:1023493. Nazarian A, Loiko E, Yassine HN, Finch CE, Kulminski AM. PMID: 36389057; PMCID: PMC9650319.
      View in: PubMed   Mentions: 2  
    25. Radiosynthesis of 20-[18F]fluoroarachidonic acid for PET-MR imaging: Biological evaluation in ApoE4-TR mice. Prostaglandins Leukot Essent Fatty Acids. 2022 11; 186:102510. Van Valkenburgh J, Duro MVV, Burnham E, Chen Q, Wang S, Tran J, Kerman BE, Hwang SH, Liu X, Sta Maria NS, Zanderigo F, Croteau E, Rapoport SI, Cunnane SC, Jacobs RE, Yassine HN, Chen K. PMID: 36341886; PMCID: PMC9888757.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    26. Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer's dementia. Alzheimers Res Ther. 2022 10 11; 14(1):152. Ebright B, Assante I, Poblete RA, Wang S, Duro MV, Bennett DA, Arvanitakis Z, Louie SG, Yassine HN. PMID: 36217192; PMCID: PMC9552454.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    27. Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4: Application of single cell-type lipidomics. Ann N Y Acad Sci. 2022 12; 1518(1):84-105. Asante I, Louie S, Yassine HN. PMID: 36200578; PMCID: PMC10092192.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    28. APOE ε4 and Alzheimer's disease diagnosis associated differences in L-carnitine, GBB, TMAO, and acylcarnitines in blood and brain. Curr Res Transl Med. 2023 Jan-Mar; 71(1):103362. Huguenard CJC, Cseresznye A, Evans JE, Darcey T, Nkiliza A, Keegan AP, Luis C, Bennett DA, Arvanitakis Z, Yassine HN, Mullan M, Crawford F, Abdullah L. PMID: 36436355; PMCID: PMC10066735.
      View in: PubMed   Mentions: 7  Translation:Humans
    29. Associations between cognitive function and endogenous levels of estradiol and testosterone in adults with type 2 diabetes. J Diabetes Complications. 2022 09; 36(9):108268. Espeland MA, Howard M, Bennett W, Robusto BA, Yasar S, Hugenschmidt CE, Luchsinger JA, Bahnson J, Yassine H, Johnson KC, Cook D, Hayden KM, Action for Health in Diabetes (Look AHEAD) MIND Ancillary Study Group. PMID: 35926332; PMCID: PMC10162709.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    30. Cognitive and neuroimaging correlates of financial exploitation vulnerability in older adults without dementia: Implications for early detection of Alzheimer's disease. Neurosci Biobehav Rev. 2022 09; 140:104773. Fenton L, Weissberger GH, Boyle PA, Mosqueda L, Yassine HN, Nguyen AL, Lim AC, Han SD. PMID: 35811006; PMCID: PMC9815424.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    31. Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group. Lancet Healthy Longev. 2022 07; 3(7):e501-e512. Yassine HN, Samieri C, Livingston G, Glass K, Wagner M, Tangney C, Plassman BL, Ikram MA, Voigt RM, Gu Y, O'Bryant S, Minihane AM, Craft S, Fink HA, Judd S, Andrieu S, Bowman GL, Richard E, Albensi B, Meyers E, Khosravian S, Solis M, Carrillo M, Snyder H, Grodstein F, Scarmeas N, Schneider LS. PMID: 35821792; PMCID: PMC9273104.
      View in: PubMed   Mentions: 31     Fields:    
    32. Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys. Alzheimers Res Ther. 2022 06 24; 14(1):87. Noveir SD, Kerman BE, Xian H, Meuret C, Smadi S, Martinez AE, Johansson J, Zetterberg H, Parks BA, Kuklenyik Z, Mack WJ, Johansson JO, Yassine HN. PMID: 35751102; PMCID: PMC9229758.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    33. Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Mol Neurodegener. 2022 06 15; 17(1):42. Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Sullivan PM, Yassine HN. PMID: 35705959; PMCID: PMC9202185.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    34. The small HDL particle hypothesis of Alzheimer's disease. Alzheimers Dement. 2023 02; 19(2):391-404. Martinez AE, Weissberger G, Kuklenyik Z, He X, Meuret C, Parekh T, Rees JC, Parks BA, Gardner MS, King SM, Collier TS, Harrington MG, Sweeney MD, Wang X, Zlokovic BV, Joe E, Nation DA, Schneider LS, Chui HC, Barr JR, Han SD, Krauss RM, Yassine HN. PMID: 35416404; PMCID: PMC10563117.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    35. Retraction Note: Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Mol Neurodegener. 2022 02 04; 17(1):14. Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Miller C, Sullivan PM, Wang HY, Yassine HN. PMID: 35115039; PMCID: PMC8815133.
      View in: PubMed   Mentions: 1     Fields:    
    36. Lipids and brain inflammation in APOE4-associated dementia. Curr Opin Lipidol. 2022 02 01; 33(1):16-24. Duro MV, Ebright B, Yassine HN. PMID: 34907965; PMCID: PMC8769806.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    37. An Association Between Saturated Fatty Acid-Containing Phosphatidylcholine in Cerebrospinal Fluid with Tau Phosphorylation. J Alzheimers Dis. 2022; 87(2):609-617. Solomon V, Hafez M, Xian H, Harrington MG, Fonteh A, Yassine HN. PMID: 35367966.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    38. Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in-depth exploration of seven established risk factors. Alzheimers Dement (N Y). 2021; 7(1):e12202. Peters R, Breitner J, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH, Kehoe PG, Beckett N, Weber C, Anderson C, Anstey KJ, Dodge HH. PMID: 34934803; PMCID: PMC8655351.
      View in: PubMed   Mentions: 7  
    39. Personalized nutrition for dementia prevention. Alzheimers Dement. 2022 07; 18(7):1424-1437. Samieri C, Yassine HN, Melo van Lent D, Lefèvre-Arbogast S, van de Rest O, Bowman GL, Scarmeas N. PMID: 34757699.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    40. The epidemiology is promising, but the trial evidence is weak. Why pharmacological dementia risk reduction trials haven't lived up to expectations, and where do we go from here? Alzheimers Dement. 2022 03; 18(3):507-512. Peters R, Dodge HH, James S, Jicha GA, Meyer PF, Richards M, Smith AD, Yassine HN, Abner E, Hainsworth AH, Kehoe PG, Beckett N, Anderson CS, Anstey KJ. PMID: 34726352.
      View in: PubMed   Mentions: 6     Fields:    
    41. Brain energy failure in dementia syndromes: Opportunities and challenges for glucagon-like peptide-1 receptor agonists. Alzheimers Dement. 2022 03; 18(3):478-497. Yassine HN, Solomon V, Thakral A, Sheikh-Bahaei N, Chui HC, Braskie MN, Schneider LS, Talbot K. PMID: 34647685; PMCID: PMC8940606.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    42. Editorial: Lipid Metabolism and Transport in CNS Health and Disease. Front Physiol. 2021; 12:768417. Bruce KD, Yassine HN, Fonteh AN. PMID: 34721089; PMCID: PMC8548761.
      View in: PubMed   Mentions:
    43. Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative Diseases. Front Physiol. 2021; 12:700847. Van Valkenburgh J, Meuret C, Martinez AE, Kodancha V, Solomon V, Chen K, Yassine HN. PMID: 34552500; PMCID: PMC8450374.
      View in: PubMed   Mentions: 16  
    44. Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. Mol Neurodegener. 2021 04 16; 16(1):26. Wang S, Li B, Solomon V, Fonteh A, Rapoport SI, Bennett DA, Arvanitakis Z, Chui HC, Miller C, Sullivan PM, Wang HY, Yassine HN. PMID: 33863362; PMCID: PMC8052701.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    45. Sex-related differences in cognitive trajectories in older individuals with type 2 diabetes and overweight or obesity. Alzheimers Dement (N Y). 2021; 7(1):e12160. Espeland MA, Yassine H, Hayden KD, Hugenschmidt C, Bennett WL, Chao A, Neiberg R, Kahn SE, Luchsinger JA, Action for Health in Diabetes (Look AHEAD) Research Group. PMID: 33860069; PMCID: PMC8033410.
      View in: PubMed   Mentions: 5  
    46. Distinct patterns of apolipoprotein C-I, C-II, and C-III isoforms are associated with markers of Alzheimer's disease. J Lipid Res. 2021; 62:100014. Hu Y, Meuret C, Martinez A, Yassine HN, Nedelkov D. PMID: 33518512; PMCID: PMC7859854.
      View in: PubMed   Mentions: 8     Fields:    
    47. THE PREVALENCE OF PROBABLE FAMILIAL CHYLOMICRONEMIA SYNDROME IN A SOUTHERN CALIFORNIA POPULATION. Endocr Pract. 2021 Jan; 27(1):71-76. Tripathi M, Wong A, Solomon V, Yassine HN. PMID: 33475504.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    48. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine. 2020 Sep; 59:102883. Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. PMID: 32690472; PMCID: PMC7502665.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    49. APOE Alleles and Diet in Brain Aging and Alzheimer's Disease. Front Aging Neurosci. 2020; 12:150. Yassine HN, Finch CE. PMID: 32587511; PMCID: PMC7297981.
      View in: PubMed   Mentions: 59  
    50. Do menopausal status and APOE4 genotype alter the long-term effects of intensive lifestyle intervention on cognitive function in women with type 2 diabetes mellitus? Neurobiol Aging. 2020 08; 92:61-72. Yassine HN, Anderson A, Brinton R, Carmichael O, Espeland MA, Hoscheidt S, Hugenschmidt CE, Keller JN, Peters A, Pi-Sunyer X. PMID: 32388179; PMCID: PMC7269875.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    51. Sex-Related Differences in Brain Volumes and Cerebral Blood Flow Among Overweight and Obese Adults With Type 2 Diabetes: Exploratory Analyses From the Action for Health in Diabetes Brain Magnetic Resonance Imaging Study. J Gerontol A Biol Sci Med Sci. 2020 03 09; 75(4):771-778. Espeland MA, Hayden KM, Lockhart SN, Yassine HN, Hoscheidt S, Yasar S, Luchsinger JA, Neiberg RH, Diaz Brinton R, Carmichael O. PMID: 30997482; PMCID: PMC7205422.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    52. Effect of APOE Genotype on Plasma Docosahexaenoic Acid (DHA), Eicosapentaenoic Acid, Arachidonic Acid, and Hippocampal Volume in the Alzheimer's Disease Cooperative Study-Sponsored DHA Clinical Trial. J Alzheimers Dis. 2020; 74(3):975-990. Tomaszewski N, He X, Solomon V, Lee M, Mack WJ, Quinn JF, Braskie MN, Yassine HN. PMID: 32116250; PMCID: PMC7156328.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    53. Simple and Fast Assay for Apolipoprotein E Phenotyping and Glycotyping: Discovering Isoform-Specific Glycosylation in Plasma and Cerebrospinal Fluid. J Alzheimers Dis. 2020; 76(3):883-893. Hu Y, Meuret C, Go S, Yassine HN, Nedelkov D. PMID: 32568201; PMCID: PMC7504994.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    54. ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes. J Neurosci. 2019 11 27; 39(48):9611-9622. Rawat V, Wang S, Sima J, Bar R, Liraz O, Gundimeda U, Parekh T, Chan J, Johansson JO, Tang C, Chui HC, Harrington MG, Michaelson DM, Yassine HN. PMID: 31641056; PMCID: PMC6880458.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    55. ApoC-III Glycoforms Are Differentially Cleared by Hepatic TRL (Triglyceride-Rich Lipoprotein) Receptors. Arterioscler Thromb Vasc Biol. 2019 10; 39(10):2145-2156. Kegulian NC, Ramms B, Horton S, Trenchevska O, Nedelkov D, Graham MJ, Lee RG, Esko JD, Yassine HN, Gordts PLSM. PMID: 31390883; PMCID: PMC6761044.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    56. Development of a delayed-release nutrient for appetite control in adults with obesity and type 2 diabetes and initial clinical testing in a single dose randomized controlled trial. Nutr Diabetes. 2019 07 15; 9(1):20. Beale E, Lim E, Yassine H, Azen C, Christopher C. PMID: 31308360; PMCID: PMC6629646.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. Low-Density Lipoprotein Particle Size Subfractions and Cerebral Amyloidosis. J Alzheimers Dis. 2019; 68(3):983-990. Lee S, Parekh T, King SM, Reed B, Chui HC, Krauss RM, Yassine HN. PMID: 30883362.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    58. Targeting prodromal Alzheimer's disease: too late for prevention? Lancet Neurol. 2017 12; 16(12):946-947. Yassine HN. PMID: 29097165; PMCID: PMC5808883.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    59. Ex vivo instability of glycated albumin: A role for autoxidative glycation. Arch Biochem Biophys. 2017 09 01; 629:36-42. Jeffs JW, Ferdosi S, Yassine HN, Borges CR. PMID: 28712850; PMCID: PMC5568244.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    60. Lessons from the Multidomain Alzheimer Preventive Trial. Lancet Neurol. 2017 08; 16(8):585-586. Yassine HN, Schneider LS. PMID: 28721922; PMCID: PMC5812698.
      View in: PubMed   Mentions: 6     Fields:    
    61. DHA brain uptake and APOE4 status: a PET study with [1-11C]-DHA. Alzheimers Res Ther. 2017 Mar 23; 9(1):23. Yassine HN, Croteau E, Rawat V, Hibbeln JR, Rapoport SI, Cunnane SC, Umhau JC. PMID: 28335828; PMCID: PMC5364667.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    62. Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers: A Review. JAMA Neurol. 2017 Mar 01; 74(3):339-347. Yassine HN, Braskie MN, Mack WJ, Castor KJ, Fonteh AN, Schneider LS, Harrington MG, Chui HC. PMID: 28114437; PMCID: PMC5812012.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    63. Changes in low-density lipoprotein size phenotypes associate with changes in apolipoprotein C-III glycoforms after dietary interventions. J Clin Lipidol. 2017 Jan - Feb; 11(1):224-233.e2. Mendoza S, Trenchevska O, King SM, Nelson RW, Nedelkov D, Krauss RM, Yassine HN. PMID: 28391889; PMCID: PMC5790205.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    64. Association of Cystatin C Proteoforms with Estimated Glomerular Filtration Rate. Clin Mass Spectrom. 2016 Nov; 1:27-31. Trenchevska O, Koska J, Sinari S, Yassine H, Reaven PD, Billheimer DD, Nelson RW, Nedelkov D. PMID: 36778895; PMCID: PMC9913891.
      View in: PubMed   Mentions: 2  
    65. Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis. JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. Yassine HN, Feng Q, Azizkhanian I, Rawat V, Castor K, Fonteh AN, Harrington MG, Zheng L, Reed BR, DeCarli C, Jagust WJ, Chui HC. PMID: 27532692.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    66. Development of quantitative mass spectrometric immunoassay for serum amyloid A. Biomarkers. 2016 Dec; 21(8):743-751. Trenchevska O, Yassine HN, Borges CR, Nelson RW, Nedelkov D. PMID: 27308834; PMCID: PMC5253327.
      View in: PubMed   Mentions: 5     Fields:    
    67. The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease. Alzheimers Res Ther. 2016 06 30; 8:25. Yassine HN, Rawat V, Mack WJ, Quinn JF, Yurko-Mauro K, Bailey-Hall E, Aisen PS, Chui HC, Schneider LS. PMID: 27358067; PMCID: PMC4928349.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    68. The association of plasma cystatin C proteoforms with diabetic chronic kidney disease. Proteome Sci. 2016; 14:7. Yassine HN, Trenchevska O, Dong Z, Bashawri Y, Koska J, Reaven PD, Nelson RW, Nedelkov D. PMID: 27019641; PMCID: PMC4807542.
      View in: PubMed   Mentions: 12  
    69. Posttranslational modifications of apolipoprotein A-II proteoforms in type 2 diabetes. J Clin Lipidol. 2016 Jul-Aug; 10(4):808-815. Azizkhanian I, Trenchevska O, Bashawri Y, Hu J, Koska J, Reaven PD, Nelson RW, Nedelkov D, Yassine HN. PMID: 27578111; PMCID: PMC5195850.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    70. Disialylated apolipoprotein C-III proteoform is associated with improved lipids in prediabetes and type 2 diabetes. J Lipid Res. 2016 05; 57(5):894-905. Koska J, Yassine H, Trenchevska O, Sinari S, Schwenke DC, Yen FT, Billheimer D, Nelson RW, Nedelkov D, Reaven PD. PMID: 26945091; PMCID: PMC4847634.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    71. ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease. J Am Heart Assoc. 2016 Feb 12; 5(2). Yassine HN, Feng Q, Chiang J, Petrosspour LM, Fonteh AN, Chui HC, Harrington MG. PMID: 26873692; PMCID: PMC4802440.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    72. The Association of Human Apolipoprotein C-III Sialylation Proteoforms with Plasma Triglycerides. PLoS One. 2015; 10(12):e0144138. Yassine HN, Trenchevska O, Ramrakhiani A, Parekh A, Koska J, Walker RW, Billheimer D, Reaven PD, Yen FT, Nelson RW, Goran MI, Nedelkov D. PMID: 26633899; PMCID: PMC4669142.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    73. Site specific modification of the human plasma proteome by methylglyoxal. Toxicol Appl Pharmacol. 2015 Dec 01; 289(2):155-62. Kimzey MJ, Kinsky OR, Yassine HN, Tsaprailis G, Stump CS, Monks TJ, Lau SS. PMID: 26435215; PMCID: PMC4651758.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    74. Serum amyloid a truncations in type 2 diabetes mellitus. PLoS One. 2015; 10(1):e0115320. Yassine HN, Trenchevska O, He H, Borges CR, Nedelkov D, Mack W, Kono N, Koska J, Reaven PD, Nelson RW. PMID: 25607823; PMCID: PMC4301920.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCTClinical Trials
    75. The Application of Multiple Reaction Monitoring to Assess Apo A-I Methionine Oxidations in Diabetes and Cardiovascular Disease. Transl Proteom. 2014 Dec 01; 4-5:18-24. Yassine HN, Jackson AM, Reaven PD, Nedelkov D, Nelson RW, Lau SS, Borchers CH. PMID: 25705587; PMCID: PMC4331021.
      View in: PubMed   Mentions: 14  
    76. A case report of defective endogenous vitamin D: a new clinical entity. Clin Cases Miner Bone Metab. 2014 May; 11(2):142-4. Alavala A, Yassine H, Szerlip HM. PMID: 25285147; PMCID: PMC4172186.
      View in: PubMed   Mentions:
    77. Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions. Mol Cell Proteomics. 2014 Jul; 13(7):1890-9. Borges CR, Rehder DS, Jensen S, Schaab MR, Sherma ND, Yassine H, Nikolova B, Breburda C. PMID: 24736286; PMCID: PMC4083123.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    78. Enhanced cholesterol efflux to HDL through the ABCA1 transporter in hypertriglyceridemia of type 2 diabetes. Metabolism. 2014 May; 63(5):727-34. Yassine HN, Belopolskaya A, Schall C, Stump CS, Lau SS, Reaven PD. PMID: 24636347; PMCID: PMC4014062.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    79. The application of multiple reaction monitoring and multi-analyte profiling to HDL proteins. Lipids Health Dis. 2014 Jan 08; 13:8. Yassine HN, Jackson AM, Borges CR, Billheimer D, Koh H, Smith D, Reaven P, Lau SS, Borchers CH. PMID: 24397693; PMCID: PMC3900256.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    80. The use of metformin is associated with decreased lumbar radiculopathy pain. J Pain Res. 2013; 6:755-63. Taylor A, Westveld AH, Szkudlinska M, Guruguri P, Annabi E, Patwardhan A, Price TJ, Yassine HN. PMID: 24357937; PMCID: PMC3862700.
      View in: PubMed   Mentions: 38  
    81. Mass spectrometric immunoassay and MRM as targeted MS-based quantitative approaches in biomarker development: potential applications to cardiovascular disease and diabetes. Proteomics Clin Appl. 2013 Aug; 7(7-8):528-40. Yassine H, Borges CR, Schaab MR, Billheimer D, Stump C, Reaven P, Lau SS, Nelson R. PMID: 23696124; PMCID: PMC4029342.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    82. Proteomic and functional annotation analysis of injured peripheral nerves reveals ApoE as a protein upregulated by injury that is modulated by metformin treatment. Mol Pain. 2013 Mar 26; 9:14. Melemedjian OK, Yassine HN, Shy A, Price TJ. PMID: 23531341; PMCID: PMC3623807.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    83. Erlotinib-associated exacerbation of hypothyroidism with pericardial tamponade. Endocr Pract. 2012 Sep-Oct; 18(5):e111-3. Kastoon T, Stump CS, Thomson SP, Yassine H. PMID: 22440982.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    84. Adjusting for Urinary Creatinine Overestimates Arsenic Concentrations in Diabetics. Cardiorenal Med. 2012 Feb; 2(1):26-32. Yassine H, Kimzey MJ, Galligan MA, Gandolfi AJ, Stump CS, Lau SS. PMID: 22493600; PMCID: PMC3318926.
      View in: PubMed   Mentions: 9     Fields:    
    85. Effect of glucose or fat challenge on aspirin resistance in diabetes. Int J Endocrinol. 2010; 2010:820876. Yassine HN, Davis-Gorman G, Stump CS, Thomson SS, Peterson J, McDonagh PF. PMID: 21318184; PMCID: PMC3034931.
      View in: PubMed   Mentions: 1  
    86. New site(s) of methylglyoxal-modified human serum albumin, identified by multiple reaction monitoring, alter warfarin binding and prostaglandin metabolism. Chem Biol Interact. 2011 Jun 30; 192(1-2):122-8. Kimzey MJ, Yassine HN, Riepel BM, Tsaprailis G, Monks TJ, Lau SS. PMID: 20934417; PMCID: PMC3050118.
      View in: PubMed   Mentions: 8     Fields:    
    87. Clinical determinants of aspirin resistance in diabetes. Diabetes Res Clin Pract. 2010 Oct; 90(1):e19-21. Yassine HN, Davis-Gorman G, Stump CS, Thomson SS, Peterson J, McDonagh PF. PMID: 20719400; PMCID: PMC2962939.
      View in: PubMed   Mentions: 4     Fields:    
    88. Effects of exercise and caloric restriction on insulin resistance and cardiometabolic risk factors in older obese adults--a randomized clinical trial. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):90-5. Yassine HN, Marchetti CM, Krishnan RK, Vrobel TR, Gonzalez F, Kirwan JP. PMID: 19164269; PMCID: PMC2691195.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
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