Abhay Sagare, PhD

Title(s)Assistant Professor of Research Physiology & Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 301, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1911
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    Other Positions
    Title(s)Assistant Director, Biomarkers Assay Core


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr 05. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 38580816.
      View in: PubMed   Mentions:    Fields:    
    2. Retraction Note: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2024 Apr 03; 15(1):2882. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 38570509; PMCID: PMC10991248.
      View in: PubMed   Mentions:    Fields:    
    3. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2024 Mar 22; 19(1):27. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 38519970; PMCID: PMC10960407.
      View in: PubMed   Mentions:    Fields:    
    4. Fluid biomarkers of the neurovascular unit in cerebrovascular disease and vascular cognitive disorders: A systematic review and meta-analysis. Cereb Circ Cogn Behav. 2024; 6:100216. Hansra GK, Jayasena T, Hosoki S, Poljak A, Lam BCP, Rust R, Sagare A, Zlokovic B, Thalamuthu A, Sachdev PS. PMID: 38510579; PMCID: PMC10951911.
      View in: PubMed   Mentions:
    5. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024 Jan; 27(1):208. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 37985802.
      View in: PubMed   Mentions:    Fields:    
    6. Age of onset predicted by Aβ profiling in a novel PSEN1 (I180F) mutation. Neurosci Lett. 2024 Jan 18; 820:137591. Robbie L, Fernández SG, Montoya L, Sagare A, Barrera L, Sheikh-Bahaei N, Gutierrez LC, Ringman JM. PMID: 38103630.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Molecular biomarkers for vascular cognitive impairment and dementia. Nat Rev Neurol. 2023 12; 19(12):737-753. Hosoki S, Hansra GK, Jayasena T, Poljak A, Mather KA, Catts VS, Rust R, Sagare A, Kovacic JC, Brodtmann A, Wallin A, Zlokovic BV, Ihara M, Sachdev PS. PMID: 37957261.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging. Neuron. 2023 Oct 04; 111(19):3131-3132. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 37797582; PMCID: PMC10765950.
      View in: PubMed   Mentions:    Fields:    
    9. Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2023 Oct 03; 14(1):6151. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 37788984; PMCID: PMC10547792.
      View in: PubMed   Mentions:    Fields:    
    10. Author Correction: Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2023 May; 617(7961):E12. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 37142785.
      View in: PubMed   Mentions:    Fields:    
    11. Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease. Alzheimers Dement. 2023 Nov; 19(11):5103-5113. Adhikari S, Qiao Y, Singer M, Sagare A, Jiang X, Shi Y, Ringman JM, Kashani AH. PMID: 37102308; PMCID: PMC10603214.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    12. Decreased functional connectivity is associated with increased levels of Cerebral Spinal Fluid soluble-PDGFRβ, a marker of blood brain barrier breakdown, in older adults. Res Sq. 2023 Mar 07. Contreras JA, Fujisaki K, Ortega N, Barisano G, Sagare A, Pappas I, Chui H, Ringman JM, Joe EB, Zlokovic B, Toga AW, Pa J. PMID: 36945439; PMCID: PMC10029080.
      View in: PubMed   Mentions:
    13. Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 Feb 24; 18(1):14. Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36829231; PMCID: PMC9960439.
      View in: PubMed   Mentions:    Fields:    
    14. Placental growth factor as a sensitive biomarker for vascular cognitive impairment. Alzheimers Dement. 2023 08; 19(8):3519-3527. Hinman JD, Elahi F, Chong D, Radabaugh H, Ferguson A, Maillard P, Thompson JF, Rosenberg GA, Sagare A, Moghekar A, Lu H, Lee T, Wilcock D, Satizabal CL, Tracy R, Seshadri S, Schwab K, Helmer K, Singh H, Kivisäkk P, Greenberg S, DeCarli C, Kramer J. PMID: 36815663; PMCID: PMC10440207.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. Characterization of spastic paraplegia in a family with a novel PSEN1 mutation. Brain Commun. 2023; 5(2):fcad030. Ringman JM, Dorrani N, Fernández SG, Signer R, Martinez-Agosto J, Lee H, Douine ED, Qiao Y, Shi Y, D'Orazio L, Pawar S, Robbie L, Kashani AH, Singer M, Byers JT, Magaki S, Guzman S, Sagare A, Zlokovic B, Cederbaum S, Nelson S, Sheikh-Bahaei N, Chui HC, Chávez-Gutiérrez L, Vinters HV. PMID: 36895955; PMCID: PMC9991506.
      View in: PubMed   Mentions: 1  
    16. Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier. Mol Neurodegener. 2023 01 27; 18(1):7. Kisler K, Sagare AP, Lazic D, Bazzi S, Lawson E, Hsu CJ, Wang Y, Ramanathan A, Nelson AR, Zhao Z, Zlokovic BV. PMID: 36707892; PMCID: PMC9883925.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    17. Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2022 Nov 03; 17(1):71. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 36329501; PMCID: PMC9632156.
      View in: PubMed   Mentions: 1     Fields:    
    18. A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. J Exp Med. 2022 11 07; 219(11). Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV. PMID: 36040482; PMCID: PMC9435921.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    19. Brain barriers and their potential role in migraine pathophysiology. J Headache Pain. 2022 Jan 26; 23(1):16. Wiggers A, Ashina H, Hadjikhani N, Sagare A, Zlokovic BV, Lauritzen M, Ashina M. PMID: 35081902; PMCID: PMC8903554.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    20. Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C. J Exp Med. 2022 01 03; 219(1). Huuskonen MT, Wang Y, Nikolakopoulou AM, Montagne A, Dai Z, Lazic D, Sagare AP, Zhao Z, Fernandez JA, Griffin JH, Zlokovic BV. PMID: 34846535; PMCID: PMC8635278.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. On the intersection between systemic infection, brain vascular dysfunction and dementia. Brain. 2021 07 28; 144(6):1629-1631. Huuskonen MT, Kisler K, Sagare AP, Zlokovic BV. PMID: 33974045; PMCID: PMC8320279.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Author Correction: APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021 Jul; 1(7):624. Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV. PMID: 37117809.
      View in: PubMed   Mentions: 2  
    23. APOE4 accelerates advanced-stage vascular and neurodegenerative disorder in old Alzheimer's mice via cyclophilin A independently of amyloid-β. Nat Aging. 2021 06; 1(6):506-520. Montagne A, Nikolakopoulou AM, Huuskonen MT, Sagare AP, Lawson EJ, Lazic D, Rege SV, Grond A, Zuniga E, Barnes SR, Prince J, Sagare M, Hsu CJ, LaDu MJ, Jacobs RE, Zlokovic BV. PMID: 35291561; PMCID: PMC8920485.
      View in: PubMed   Mentions: 44  Translation:Animals
    24. Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A. J Exp Med. 2021 04 05; 218(4). Nikolakopoulou AM, Wang Y, Ma Q, Sagare AP, Montagne A, Huuskonen MT, Rege SV, Kisler K, Dai Z, Körbelin J, Herz J, Zhao Z, Zlokovic BV. PMID: 33533918; PMCID: PMC7863706.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    25. Evidence that blood-CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache. 2021 Mar; 61(3):536-545. Cowan RP, Gross NB, Sweeney MD, Sagare AP, Montagne A, Arakaki X, Fonteh AN, Zlokovic BV, Pogoda JM, Harrington MG. PMID: 33724462; PMCID: PMC8023403.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    26. Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults. Brain Behav Immun. 2021 05; 94:299-307. Albrecht DS, Sagare A, Pachicano M, Sweeney MD, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Morris JC, Benzinger T, Pa J. PMID: 33486003; PMCID: PMC8793040.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    27. MarkVCID cerebral small vessel consortium: I. Enrollment, clinical, fluid protocols. Alzheimers Dement. 2021 04; 17(4):704-715. Wilcock D, Jicha G, Blacker D, Albert MS, D'Orazio LM, Elahi FM, Fornage M, Hinman JD, Knoefel J, Kramer J, Kryscio RJ, Lamar M, Moghekar A, Prestopnik J, Ringman JM, Rosenberg G, Sagare A, Satizabal CL, Schneider J, Seshadri S, Sur S, Tracy RP, Yasar S, Williams V, Singh H, Mazina L, Helmer KG, Corriveau RA, Schwab K, Kivisäkk P, Greenberg SM, MarkVCID Consortium. PMID: 33480172; PMCID: PMC8122220.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    28. Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid. J Neurosci. 2020 10 28; 40(44):8573-8586. Albrecht D, Isenberg AL, Stradford J, Monreal T, Sagare A, Pachicano M, Sweeney M, Toga A, Zlokovic B, Chui H, Joe E, Schneider L, Conti P, Jann K, Pa J. PMID: 33046556; PMCID: PMC7605425.
      View in: PubMed   Mentions: 41     Fields:    Translation:Humans
    29. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. EBioMedicine. 2020 Sep; 59:102883. Arellanes IC, Choe N, Solomon V, He X, Kavin B, Martinez AE, Kono N, Buennagel DP, Hazra N, Kim G, D'Orazio LM, McCleary C, Sagare A, Zlokovic BV, Hodis HN, Mack WJ, Chui HC, Harrington MG, Braskie MN, Schneider LS, Yassine HN. PMID: 32690472; PMCID: PMC7502665.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    30. Correction: Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(7):e0236379. Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32663228; PMCID: PMC7360049.
      View in: PubMed   Mentions: 2     Fields:    
    31. Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline. PLoS One. 2020; 15(5):e0232785. Asanad S, Fantini M, Sultan W, Nassisi M, Felix CM, Wu J, Karanjia R, Ross-Cisneros FN, Sagare AP, Zlokovic BV, Chui HC, Pogoda JM, Arakaki X, Fonteh AN, Sadun AA, Harrington MG. PMID: 32469871; PMCID: PMC7259639.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    32. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954; PMCID: PMC7250000.
      View in: PubMed   Mentions: 439     Fields:    Translation:HumansCells
    33. A novel sensitive assay for detection of a biomarker of pericyte injury in cerebrospinal fluid. Alzheimers Dement. 2020 06; 16(6):821-830. Sweeney MD, Sagare AP, Pachicano M, Harrington MG, Joe E, Chui HC, Schneider LS, Montagne A, Ringman JM, Fagan AM, Morris JC, Pa J, Nation DA, Toga AW, Zlokovic BV. PMID: 32301266; PMCID: PMC7986963.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    34. Functional connectivity among brain regions affected in Alzheimer's disease is associated with CSF TNF-α in APOE4 carriers. Neurobiol Aging. 2020 02; 86:112-122. Contreras JA, Aslanyan V, Sweeney MD, Sanders LMJ, Sagare AP, Zlokovic BV, Toga AW, Han SD, Morris JC, Fagan A, Massoumzadeh P, Benzinger TL, Pa J. PMID: 31870643; PMCID: PMC7205323.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. PMID: 31310593; PMCID: PMC6693831.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    36. Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss. Nat Neurosci. 2019 07; 22(7):1089-1098. Nikolakopoulou AM, Montagne A, Kisler K, Dai Z, Wang Y, Huuskonen MT, Sagare AP, Lazic D, Sweeney MD, Kong P, Wang M, Owens NC, Lawson EJ, Xie X, Zhao Z, Zlokovic BV. PMID: 31235908; PMCID: PMC6668719.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    37. Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits. Trends Mol Med. 2019 02; 25(2):74-76. Sagare AP, Sweeney MD, Nelson AR, Zhao Z, Zlokovic BV. PMID: 30661727; PMCID: PMC6377285.
      View in: PubMed   Mentions: 2     Fields:    
    38. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. J Exp Med. 2019 02 04; 216(2):279-293. Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. PMID: 30647119; PMCID: PMC6363429.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    39. Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med. 2019 02; 25(2):270-276. Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M, Sepehrband F, Nelson AR, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Chui HC, Law M, Toga AW, Zlokovic BV. PMID: 30643288; PMCID: PMC6367058.
      View in: PubMed   Mentions: 613     Fields:    Translation:Humans
    40. Vascular dysfunction-The disregarded partner of Alzheimer's disease. Alzheimers Dement. 2019 01; 15(1):158-167. Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Al-Shahi Salman R, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV. PMID: 30642436; PMCID: PMC6338083.
      View in: PubMed   Mentions: 278     Fields:    Translation:Humans
    41. Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism. Mol Neurodegener. 2018 10 19; 13(1):57. Ma Q, Zhao Z, Sagare AP, Wu Y, Wang M, Owens NC, Verghese PB, Herz J, Holtzman DM, Zlokovic BV. PMID: 30340601; PMCID: PMC6194676.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    42. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711; PMCID: PMC5840035.
      View in: PubMed   Mentions: 183     Fields:    
    43. Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders. Nat Rev Neurol. 2018 03; 14(3):133-150. Sweeney MD, Sagare AP, Zlokovic BV. PMID: 29377008; PMCID: PMC5829048.
      View in: PubMed   Mentions: 978     Fields:    Translation:Humans
    44. Can adjunctive therapies augment the efficacy of endovascular thrombolysis? A potential role for activated protein C. Neuropharmacology. 2018 05 15; 134(Pt B):293-301. Amar AP, Sagare AP, Zhao Z, Wang Y, Nelson AR, Griffin JH, Zlokovic BV. PMID: 28923278; PMCID: PMC5857404.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    45. Role of clusterin in the brain vascular clearance of amyloid-β. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8681-8682. Nelson AR, Sagare AP, Zlokovic BV. PMID: 28765369; PMCID: PMC5565473.
      View in: PubMed   Mentions: 44     Fields:    Translation:Humans
    46. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease. Biochim Biophys Acta. 2016 05; 1862(5):887-900. Nelson AR, Sweeney MD, Sagare AP, Zlokovic BV. PMID: 26705676; PMCID: PMC4821735.
      View in: PubMed   Mentions: 229     Fields:    Translation:HumansAnimals
    47. Shedding of soluble platelet-derived growth factor receptor-β from human brain pericytes. Neurosci Lett. 2015 Oct 21; 607:97-101. Sagare AP, Sweeney MD, Makshanoff J, Zlokovic BV. PMID: 26407747; PMCID: PMC4631673.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    48. Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer's disease: the role, regulation and restoration of LRP1. Front Aging Neurosci. 2015; 7:136. Ramanathan A, Nelson AR, Sagare AP, Zlokovic BV. PMID: 26236233; PMCID: PMC4502358.
      View in: PubMed   Mentions: 93  
    49. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850; PMCID: PMC4482781.
      View in: PubMed   Mentions: 218     Fields:    Translation:HumansAnimalsCells
    50. Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1055-68. Sweeney MD, Sagare AP, Zlokovic BV. PMID: 25899298; PMCID: PMC4640280.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    51. GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration. Nat Neurosci. 2015 Apr; 18(4):521-530. Winkler EA, Nishida Y, Sagare AP, Rege SV, Bell RD, Perlmutter D, Sengillo JD, Hillman S, Kong P, Nelson AR, Sullivan JS, Zhao Z, Meiselman HJ, Wendy RB, Soto J, Abel ED, Makshanoff J, Zuniga E, De Vivo DC, Zlokovic BV. PMID: 25730668; PMCID: PMC4734893.
      View in: PubMed   Mentions: 284     Fields:    Translation:Animals
    52. Blood-brain barrier breakdown in the aging human hippocampus. Neuron. 2015 Jan 21; 85(2):296-302. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV. PMID: 25611508; PMCID: PMC4350773.
      View in: PubMed   Mentions: 898     Fields:    Translation:HumansCells
    53. The pericyte: a forgotten cell type with important implications for Alzheimer's disease? Brain Pathol. 2014 Jul; 24(4):371-86. Winkler EA, Sagare AP, Zlokovic BV. PMID: 24946075; PMCID: PMC4423607.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansAnimalsCells
    54. Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):E1035-42. Winkler EA, Sengillo JD, Sagare AP, Zhao Z, Ma Q, Zuniga E, Wang Y, Zhong Z, Sullivan JS, Griffin JH, Cleveland DW, Zlokovic BV. PMID: 24591593; PMCID: PMC3964055.
      View in: PubMed   Mentions: 117     Fields:    Translation:HumansAnimalsCells
    55. Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown. JAMA Neurol. 2013 Sep 01; 70(9):1198-200. Halliday MR, Pomara N, Sagare AP, Mack WJ, Frangione B, Zlokovic BV. PMID: 24030206; PMCID: PMC4047029.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    56. Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14771-6. Singh I, Sagare AP, Coma M, Perlmutter D, Gelein R, Bell RD, Deane RJ, Zhong E, Parisi M, Ciszewski J, Kasper RT, Deane R. PMID: 23959870; PMCID: PMC3767519.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    57. A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain. J Biol Chem. 2013 May 24; 288(21):15154-66. Sagare AP, Bell RD, Srivastava A, Sengillo JD, Singh I, Nishida Y, Chow N, Zlokovic BV. PMID: 23580652; PMCID: PMC3663536.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    58. Pericyte loss influences Alzheimer-like neurodegeneration in mice. Nat Commun. 2013; 4:2932. Sagare AP, Bell RD, Zhao Z, Ma Q, Winkler EA, Ramanathan A, Zlokovic BV. PMID: 24336108; PMCID: PMC3945879.
      View in: PubMed   Mentions: 338     Fields:    Translation:AnimalsCells
    59. Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease. J Alzheimers Dis. 2013; 33 Suppl 1:S87-100. Sagare AP, Bell RD, Zlokovic BV. PMID: 22751174; PMCID: PMC4416477.
      View in: PubMed   Mentions: 73     Fields:    Translation:HumansAnimals
    60. Neurovascular dysfunction and faulty amyloid β-peptide clearance in Alzheimer disease. Cold Spring Harb Perspect Med. 2012 Oct 01; 2(10). Sagare AP, Bell RD, Zlokovic BV. PMID: 23028132; PMCID: PMC3475405.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimals
    61. Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities. Pharmacol Ther. 2012 Oct; 136(1):94-105. Sagare AP, Deane R, Zlokovic BV. PMID: 22820095; PMCID: PMC3432694.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    62. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature. 2012 May 16; 485(7399):512-6. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, Holtzman DM, Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV. PMID: 22622580; PMCID: PMC4047116.
      View in: PubMed   Mentions: 642     Fields:    Translation:HumansAnimalsCells
    63. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012 Apr; 122(4):1377-92. Deane R, Singh I, Sagare AP, Bell RD, Ross NT, LaRue B, Love R, Perry S, Paquette N, Deane RJ, Thiyagarajan M, Zarcone T, Fritz G, Friedman AE, Miller BL, Zlokovic BV. PMID: 22406537; PMCID: PMC3314449.
      View in: PubMed   Mentions: 277     Fields:    Translation:HumansAnimalsCells
    64. From the liver to the blood-brain barrier: an interconnected system regulating brain amyloid-β levels. J Neurosci Res. 2011 Jul; 89(7):967-8. Sagare AP, Winkler EA, Bell RD, Deane R, Zlokovic BV. PMID: 21544850.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    65. Impaired lipoprotein receptor-mediated peripheral binding of plasma amyloid-β is an early biomarker for mild cognitive impairment preceding Alzheimer's disease. J Alzheimers Dis. 2011; 24(1):25-34. Sagare AP, Deane R, Zetterberg H, Wallin A, Blennow K, Zlokovic BV. PMID: 21157031; PMCID: PMC4096563.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    66. Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. J Neurosci. 2010 Nov 17; 30(46):15521-34. Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV. PMID: 21084607; PMCID: PMC3012432.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    67. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron. 2010 Nov 04; 68(3):409-27. Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV. PMID: 21040844; PMCID: PMC3056408.
      View in: PubMed   Mentions: 773     Fields:    Translation:AnimalsCells
    68. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010 Dec; 115(5):1077-89. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. PMID: 20854368; PMCID: PMC2972355.
      View in: PubMed   Mentions: 128     Fields:    Translation:HumansAnimals
    69. Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor. Blood. 2010 Jun 10; 115(23):4963-72. Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV. PMID: 20348395; PMCID: PMC2890172.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    70. Impaired spine formation and learning in GPCR kinase 2 interacting protein-1 (GIT1) knockout mice. Brain Res. 2010 Mar 04; 1317:218-26. Menon P, Deane R, Sagare A, Lane SM, Zarcone TJ, O'Dell MR, Yan C, Zlokovic BV, Berk BC. PMID: 20043896; PMCID: PMC2861918.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    71. Clearance of amyloid-beta peptide across the blood-brain barrier: implication for therapies in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2009 Mar; 8(1):16-30. Deane R, Bell RD, Sagare A, Zlokovic BV. PMID: 19275634; PMCID: PMC2872930.
      View in: PubMed   Mentions: 244     Fields:    Translation:HumansAnimals
    72. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53. Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. PMID: 19098903; PMCID: PMC2654279.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    73. apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest. 2008 Dec; 118(12):4002-13. Deane R, Sagare A, Hamm K, Parisi M, Lane S, Finn MB, Holtzman DM, Zlokovic BV. PMID: 19033669; PMCID: PMC2582453.
      View in: PubMed   Mentions: 368     Fields:    Translation:HumansAnimalsCells
    74. Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab. 2009 Jan; 29(1):25-33. Deane R, LaRue B, Sagare AP, Castellino FJ, Zhong Z, Zlokovic BV. PMID: 18841163; PMCID: PMC2895315.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    75. ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci. 2008 Apr; 11(4):420-2. Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV. PMID: 18344992; PMCID: PMC2895310.
      View in: PubMed   Mentions: 210     Fields:    Translation:HumansAnimalsCells
    76. The role of the cell surface LRP and soluble LRP in blood-brain barrier Abeta clearance in Alzheimer's disease. Curr Pharm Des. 2008; 14(16):1601-5. Deane R, Sagare A, Zlokovic BV. PMID: 18673201; PMCID: PMC2895311.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimals
    77. Clearance of amyloid-beta by circulating lipoprotein receptors. Nat Med. 2007 Sep; 13(9):1029-31. Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, Zlokovic BV. PMID: 17694066; PMCID: PMC2936449.
      View in: PubMed   Mentions: 200     Fields:    Translation:HumansAnimals
    78. Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab. 2007 May; 27(5):909-18. Bell RD, Sagare AP, Friedman AE, Bedi GS, Holtzman DM, Deane R, Zlokovic BV. PMID: 17077814; PMCID: PMC2853021.
      View in: PubMed   Mentions: 298     Fields:    Translation:HumansAnimals
    79. IgG-assisted age-dependent clearance of Alzheimer's amyloid beta peptide by the blood-brain barrier neonatal Fc receptor. J Neurosci. 2005 Dec 14; 25(50):11495-503. Deane R, Sagare A, Hamm K, Parisi M, LaRue B, Guo H, Wu Z, Holtzman DM, Zlokovic BV. PMID: 16354907; PMCID: PMC6726020.
      View in: PubMed   Mentions: 112     Fields:    Translation:HumansAnimals
    80. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J Clin Invest. 2005 Nov; 115(11):3285-90. Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM. PMID: 16239972; PMCID: PMC1257538.
      View in: PubMed   Mentions: 286     Fields:    Translation:AnimalsCells
    81. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med. 2005 Sep; 11(9):959-65. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, Brooks AI, Kanagala S, Rubio A, Sagare A, Liu D, Li F, Armstrong D, Gasiewicz T, Zidovetzki R, Song X, Hofman F, Zlokovic BV. PMID: 16116430.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    82. Method for measurement of the blood-brain barrier permeability in the perfused mouse brain: application to amyloid-beta peptide in wild type and Alzheimer's Tg2576 mice. J Neurosci Methods. 2004 Sep 30; 138(1-2):233-42. LaRue B, Hogg E, Sagare A, Jovanovic S, Maness L, Maurer C, Deane R, Zlokovic BV. PMID: 15325132.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    83. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 2004 Aug 05; 43(3):333-44. Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, Zlokovic BV. PMID: 15294142.
      View in: PubMed   Mentions: 414     Fields:    Translation:HumansAnimalsCells
    84. Formation of protoberberine-type alkaloids by the tubers of somatic embryo-derived plants of Corydalis yanhusuo. Planta Med. 2001 Dec; 67(9):839-42. Lee YL, Sagare AP, Lee CY, Feng HT, Ko YC, Shaw JF, Tsay HS. PMID: 11745021.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    85. De novo regeneration of Scrophularia yoshimurae Yamazaki (Scrophulariaceae) and quantitative analysis of harpagoside, an iridoid glucoside, formed in aerial and underground parts of in vitro propagated and wild plants by HPLC. Biol Pharm Bull. 2001 Nov; 24(11):1311-5. Sagare AP, Kuo CL, Chueh FS, Tsay HS. PMID: 11725970.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    86. Quantitative determination of secoiridoid glucosides in in vitro propagated plants of Gentiana davidii var. formosana by high performance liquid chromatography. Planta Med. 2001 Feb; 67(1):70-3. Chueh FS, Chen CC, Sagare AP, Tsay HS. PMID: 11270726.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    87. Cytokinin-induced somatic embryogenesis and plant regeneration in Corydalis yanhusuo (Fumariaceae) - a medicinal plant. Plant Sci. 2000 Dec 07; 160(1):139-147. Sagare AP, Lee YL, Lin TC, Chen CC, Tsay HS. PMID: 11164586.
      View in: PubMed   Mentions: 11     Fields:    
    88. Agrobacterium mediated transformation of chickpea (Cicer arietinum L.) embryo axes. Plant Cell Rep. 2000 Jan; 19(3):235-240. Krishnamurthy KV, Suhasini K, Sagare AP, Meixner M, de Kathen A, Pickardt T, Schieder O. PMID: 30754901.
      View in: PubMed   Mentions: 15     Fields:    
    89. Plant regeneration via somatic embryogenesis in chick pea (Cicer arietinum L.). Plant Cell Rep. 1993 Sep; 12(11):652-5. Sagare AP, Suhasini K, Krishnamurthy KV. PMID: 24201882.
      View in: PubMed   Mentions: 6     Fields:    
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