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Justin Ichida, PhD

Title(s)Associate Professor of Stem Cell Biology and Regenerative Medicine
AddressBCC 307 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0063
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    Other Positions
    Title(s)John Douglas French Alzheimer's Endowed Professor in Regenerative Medicine


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    The Role of C9ORF72 Protein Function in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
    NIH/NINDS R01NS097850Feb 16, 2017 - Mar 31, 2020
    Role: Principal Investigator
    Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
    NIH/NIDCD R01DC015530Jul 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Conversion of Fibroblasts to fxnal Spinal Motor Neurons Using Defined Factor
    NIH/NINDS R00NS077435Jan 1, 2013 - Dec 31, 2015
    Role: Principal Investigator
    Conversion of fibroblasts to functional spinal motor neurons using defined factor
    NIH/NINDS K99NS077435Sep 30, 2011 - Dec 31, 2012
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells. iScience. 2020 Apr 21; 23(5):101083. Hor P, Punj V, Calvert BA, Castaldi A, Miller AJ, Carraro G, Stripp BR, Brody SL, Spence JR, Ichida JK, Ryan Firth AL, Borok Z. PMID: 32380423.
      View in: PubMed   Mentions:
    2. Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions. Cell Stem Cell. 2020 Feb 06; 26(2):131-133. Ichida JK, Ko CP. PMID: 32032521.
      View in: PubMed   Mentions:    Fields:    
    3. Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. 2019 Nov; 138(5):883-884. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. PMID: 31559488.
      View in: PubMed   Mentions:    Fields:    
    4. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 11 12; 13(5):939-955. Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S. PMID: 31631020.
      View in: PubMed   Mentions:    Fields:    
    5. C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis. Neurosci Lett. 2019 11 20; 713:134523. Lai JD, Ichida JK. PMID: 31568865.
      View in: PubMed   Mentions:    Fields:    
    6. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 10 03; 25(4):486-500.e9. Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. PMID: 31523028.
      View in: PubMed   Mentions: 1     Fields:    
    7. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci. 2019 09; 22(9):1383-1388. Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD. PMID: 31358992.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    8. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. PMID: 31310593.
      View in: PubMed   Mentions:    Fields:    
    9. Directly Reprogrammed Neurons Still Have Some Growing Up to Do. Cell Stem Cell. 2019 07 03; 25(1):1-2. Li Y, Ichida JK. PMID: 31271745.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. 2019 07; 138(1):49-65. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. PMID: 30945056.
      View in: PubMed   Mentions: 2     Fields:    
    11. Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development. 2018 11 21; 145(22). Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K. PMID: 30337375.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. Biol Psychiatry. 2019 02 15; 85(4):305-316. Wilkinson B, Evgrafov OV, Zheng D, Hartel N, Knowles JA, Graham NA, Ichida JK, Coba MP. PMID: 29961565.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nat Genet. 2018 04; 50(4):603-612. Kramer NJ, Haney MS, Morgens DW, Jovicic A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. PMID: 29507424.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    14. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    15. Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI Insight. 2017 11 16; 2(22). Patten SA, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong GA, La Fontaine A, Maios C, Liao M, Ciura S, Wen XY, Rafuse V, Ichida J, Zinman L, Julien JP, Kabashi E, Robitaille R, Korngut L, Parker JA, Drapeau P. PMID: 29202456.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    16. Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury. JAMA Facial Plast Surg. 2017 May 01; 19(3):197-205. Pepper JP, Wang TV, Hennes V, Sun SY, Ichida JK. PMID: 27978547.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    17. Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 09; 35(3):358-65. Askary A, Mork L, Paul S, He X, Izuhara AK, Gopalakrishnan S, Ichida JK, McMahon AP, Dabizljevic S, Dale R, Mariani FV, Crump JG. PMID: 26555055.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    18. New approaches for direct conversion of patient fibroblasts into neural cells. Brain Res. 2017 02 01; 1656:2-13. Gopalakrishnan S, Hor P, Ichida JK. PMID: 26475975.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    19. Small Molecules Take a Big Step by Converting Fibroblasts into Neurons. Cell Stem Cell. 2015 Aug 06; 17(2):127-9. Babos K, Ichida JK. PMID: 26253195.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    20. Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    21. Probing disorders of the nervous system using reprogramming approaches. EMBO J. 2015 Jun 03; 34(11):1456-77. Ichida JK, Kiskinis E. PMID: 25925386.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    22. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. 2015 Jan 21; 35(3):1291-306. Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF. PMID: 25609642.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 2014 Dec 17; 84(6):1213-25. Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. PMID: 25521377.
      View in: PubMed   Mentions: 109     Fields:    Translation:HumansAnimalsCells
    24. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. PMID: 25420066.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    25. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639. Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. PMID: 24952596.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    26. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. PMID: 24746641.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. PMID: 24704492.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansCells
    28. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2014 Feb 11; 2(2):119-26. Carter AC, Davis-Dusenbery BN, Koszka K, Ichida JK, Eggan K. PMID: 24527385.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    29. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cell Reprogram. 2013 Dec; 15(6):495-502. Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. PMID: 24182315.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    30. ß-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells. PLoS One. 2013; 8(5):e63265. Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A. PMID: 23691006.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    31. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. PMID: 23474986.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    32. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. PMID: 21971503.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 02; 9(3):205-18. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. PMID: 21852222.
      View in: PubMed   Mentions: 248     Fields:    Translation:HumansAnimalsCells
    34. Shushing down the epigenetic landscape towards stem cell differentiation. Development. 2010 Aug 01; 137(15):2455-60. Ichida JK, Kiskinis E, Eggan K. PMID: 20554719.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    35. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. PMID: 20359213.
      View in: PubMed   Mentions: 34     Fields:    Translation:Cells
    36. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. PMID: 19818703.
      View in: PubMed   Mentions: 272     Fields:    Translation:AnimalsCells
    37. Elucidating nuclear reprogramming mechanisms: taking a synergistic approach. Reprod Biomed Online. 2008 Jan; 16(1):41-50. Sullivan S, Ichida JK, Umezawa A, Akutsu H. PMID: 18252046.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
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