Justin Ichida, PhD

Title(s)Associate Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of Usc
AddressBCC 307 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0063
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    Other Positions
    Title(s)John Douglas French Alzheimer’s Endowed Professor in Regenerative Medicine


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    Collapse Research 
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    Validating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTD
    NIH R01NS097850Sep 1, 2016 - Jun 30, 2025
    Role: Principal Investigator
    Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
    NIH R01DC015530Jul 1, 2016 - Jun 30, 2021
    Role: Co-Principal Investigator
    Conversion of Fibroblasts to fxnal Spinal Motor Neurons Using Defined Factor
    NIH R00NS077435Jan 1, 2013 - Dec 31, 2016
    Role: Principal Investigator
    Conversion of fibroblasts to functional spinal motor neurons using defined factor
    NIH K99NS077435Sep 30, 2011 - Aug 31, 2013
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics. Clin Proteomics. 2025 Apr 28; 22(1):16. Yu SF, Michon M, Lingappa AF, Paulvannan K, Solas D, Staats K, Ichida J, Dey D, Rosenfeld J, Lingappa VR. PMID: 40295933; PMCID: PMC12036218.
      View in: PubMed   Mentions:
    2. Elucidating the Synergistic Effect of the PrimeC Combination for Amyotrophic Lateral Sclerosis in Human Induced Pluripotent Stem Cell-Derived Motor Neurons and Mouse Models. Pharmaceuticals (Basel). 2025 Apr 03; 18(4). Salomon-Zimri S, Kerem N, Linares GR, Russek-Blum N, Ichida JK, Tracik F. PMID: 40283960; PMCID: PMC12030000.
      View in: PubMed   Mentions:
    3. KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids. Neuron. 2025 Apr 16; 113(8):1169-1189.e7. Berlind JE, Lai JD, Lie C, Vicente J, Lam K, Guo S, Chang J, Yu V, Ichida JK. PMID: 40049159; PMCID: PMC12005969.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques. ACS Biomater Sci Eng. 2025 Mar 10; 11(3):1731-1740. Santoso JW, Do SK, Verma R, Do AV, Hendricks E, Ichida JK, McCain ML. PMID: 39973396; PMCID: PMC11897949.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques. bioRxiv. 2024 Dec 05. Santoso JW, Do SK, Verma R, Do AV, Hendricks E, Ichida JK, McCain ML. PMID: 39677637; PMCID: PMC11642770.
      View in: PubMed   Mentions:
    6. Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases. bioRxiv. 2024 May 14. Zhang S, Shu H, Zhou J, Rubin-Sigler J, Yang X, Liu Y, Cooper-Knock J, Monte E, Zhu C, Tu S, Li H, Tong M, Ecker JR, Ichida JK, Shen Y, Zeng J, Tsao PS, Snyder MP. PMID: 38798507; PMCID: PMC11118500.
      View in: PubMed   Mentions:
    7. KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury. Cell Stem Cell. 2024 Apr 04; 31(4):519-536.e8. Lai JD, Berlind JE, Fricklas G, Lie C, Urenda JP, Lam K, Sta Maria N, Jacobs R, Yu V, Zhao Z, Ichida JK. PMID: 38579683.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    8. Deep learning modeling of rare noncoding genetic variants in human motor neurons defines CCDC146 as a therapeutic target for ALS. medRxiv. 2024 Apr 01. Zhang S, Moll T, Rubin-Sigler J, Tu S, Li S, Yuan E, Liu M, Butt A, Harvey C, Gornall S, Alhalthli E, Shaw A, Souza CDS, Ferraiuolo L, Hornstein E, Shelkovnikova T, van Dijk CH, Timpanaro IS, Kenna KP, Zeng J, Tsao PS, Shaw PJ, Ichida JK, Cooper-Knock J, Snyder MP. PMID: 38633814; PMCID: PMC11023684.
      View in: PubMed   Mentions:
    9. Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024 Jan; 27(1):208. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 37985802.
      View in: PubMed   Mentions:    Fields:    
    10. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology. Sci Adv. 2023 11 10; 9(45):eadf7997. Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E. PMID: 37948524; PMCID: PMC10637751.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis. Cell Rep. 2023 10 31; 42(10):113160. Tsioras K, Smith KC, Edassery SL, Garjani M, Li Y, Williams C, McKenna ED, Guo W, Wilen AP, Hark TJ, Marklund SL, Ostrow LW, Gilthorpe JD, Ichida JK, Kalb RG, Savas JN, Kiskinis E. PMID: 37776851; PMCID: PMC10785776.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    12. The C9ORF72 repeat expansion alters neurodevelopment. Cell Rep. 2023 08 29; 42(8):112983. Hendricks E, Quihuis AM, Hung ST, Chang J, Dorjsuren N, Der B, Staats KA, Shi Y, Sta Maria NS, Jacobs RE, Ichida JK. PMID: 37590144; PMCID: PMC10757587.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    13. Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features. Front Cell Neurosci. 2023; 17:1179796. Lorenzini I, Alsop E, Levy J, Gittings LM, Lall D, Rabichow BE, Moore S, Pevey R, Bustos LM, Burciu C, Bhatia D, Singer M, Saul J, McQuade A, Tzioras M, Mota TA, Logemann A, Rose J, Almeida S, Gao FB, Marks M, Donnelly CJ, Hutchins E, Hung ST, Ichida J, Bowser R, Spires-Jones T, Blurton-Jones M, Gendron TF, Baloh RH, Van Keuren-Jensen K, Sattler R. PMID: 37346371; PMCID: PMC10279871.
      View in: PubMed   Mentions: 7  
    14. Transcriptomic analysis of feeder-free culture system for maintaining naïve-state pluripotency in human pluripotent stem cells. Stem Cell Investig. 2023; 10:10. Isono W, Kawasaki T, Ichida JK, Nagasaka K, Hiraike O, Umezawa A, Akutsu H. PMID: 37155477; PMCID: PMC10122725.
      View in: PubMed   Mentions:
    15. Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD. Neuron. 2023 05 03; 111(9):1381-1390.e6. Lee S, Jun YW, Linares GR, Butler B, Yuva-Adyemir Y, Moore J, Krishnan G, Ruiz-Juarez B, Santana M, Pons M, Silverman N, Weng Z, Ichida JK, Gao FB. PMID: 36931278; PMCID: PMC10264157.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. PIKFYVE inhibition mitigates disease in models of diverse forms of ALS. Cell. 2023 02 16; 186(4):786-802.e28. Hung ST, Linares GR, Chang WH, Eoh Y, Krishnan G, Mendonca S, Hong S, Shi Y, Santana M, Kueth C, Macklin-Isquierdo S, Perry S, Duhaime S, Maios C, Chang J, Perez J, Couto A, Lai J, Li Y, Alworth SV, Hendricks E, Wang Y, Zlokovic BV, Dickman DK, Parker JA, Zarnescu DC, Gao FB, Ichida JK. PMID: 36754049; PMCID: PMC10062012.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    17. SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS. Cell Stem Cell. 2023 02 02; 30(2):171-187.e14. Linares GR, Li Y, Chang WH, Rubin-Sigler J, Mendonca S, Hong S, Eoh Y, Guo W, Huang YH, Chang J, Tu S, Dorjsuren N, Santana M, Hung ST, Yu J, Perez J, Chickering M, Cheng TY, Huang CC, Lee SJ, Deng HJ, Bach KT, Gray K, Subramanyam V, Rosenfeld J, Alworth SV, Goodarzi H, Ichida JK. PMID: 36736291; PMCID: PMC10062011.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    18. Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications. Pharmacol Rev. 2023 03; 75(2):263-308. Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. PMID: 36549866; PMCID: PMC9976797.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    19. Radiogenomics of C9orf72 Expansion Carriers Reveals Global Transposable Element Derepression and Enables Prediction of Thalamic Atrophy and Clinical Impairment. J Neurosci. 2023 01 11; 43(2):333-345. Bonham LW, Geier EG, Sirkis DW, Leong JK, Ramos EM, Wang Q, Karydas A, Lee SE, Sturm VE, Sawyer RP, Friedberg A, Ichida JK, Gitler AD, Sugrue L, Cordingley M, Bee W, Weber E, Kramer JH, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Ravits J, Miller BL, Yokoyama JS. PMID: 36446586; PMCID: PMC9838702.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. A "multi-omics" analysis of blood-brain barrier and synaptic dysfunction in APOE4 mice. J Exp Med. 2022 11 07; 219(11). Barisano G, Kisler K, Wilkinson B, Nikolakopoulou AM, Sagare AP, Wang Y, Gilliam W, Huuskonen MT, Hung ST, Ichida JK, Gao F, Coba MP, Zlokovic BV. PMID: 36040482; PMCID: PMC9435921.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    21. A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nat Neurosci. 2022 09; 25(9):1149-1162. Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M. PMID: 35953545; PMCID: PMC9448678.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    22. Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS. Nat Neurosci. 2022 04; 25(4):433-445. Eitan C, Siany A, Barkan E, Olender T, van Eijk KR, Moisse M, Farhan SMK, Danino YM, Yanowski E, Marmor-Kollet H, Rivkin N, Yacovzada NS, Hung ST, Cooper-Knock J, Yu CH, Louis C, Masters SL, Kenna KP, van der Spek RAA, Sproviero W, Al Khleifat A, Iacoangeli A, Shatunov A, Jones AR, Elbaz-Alon Y, Cohen Y, Chapnik E, Rothschild D, Weissbrod O, Beck G, Ainbinder E, Ben-Dor S, Werneburg S, Schafer DP, Brown RH, Shaw PJ, Van Damme P, van den Berg LH, Phatnani H, Segal E, Ichida JK, Al-Chalabi A, Veldink JH, Project MinE ALS Sequencing Consortium, NYGC ALS Consortium, Hornstein E. PMID: 35361972; PMCID: PMC7614916.
      View in: PubMed   Mentions: 17     Fields:    
    23. Repairing the blood-brain barrier. Science. 2022 02 18; 375(6582):715-716. McMahon AP, Ichida JK. PMID: 35175806.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    24. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. 2021 08 19; 184(17):4547-4563.e17. Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S. PMID: 34314701; PMCID: PMC8635409.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansCells
    25. Engineering skeletal muscle tissues with advanced maturity improves synapse formation with human induced pluripotent stem cell-derived motor neurons. APL Bioeng. 2021 Sep; 5(3):036101. Santoso JW, Li X, Gupta D, Suh GC, Hendricks E, Lin S, Perry S, Ichida JK, Dickman D, McCain ML. PMID: 34286174; PMCID: PMC8282350.
      View in: PubMed   Mentions: 16  
    26. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). Cell. 2021 02 04; 184(3):689-708.e20. Maor-Nof M, Shipony Z, Lopez-Gonzalez R, Nakayama L, Zhang YJ, Couthouis J, Blum JA, Castruita PA, Linares GR, Ruan K, Ramaswami G, Simon DJ, Nof A, Santana M, Han K, Sinnott-Armstrong N, Bassik MC, Geschwind DH, Tessier-Lavigne M, Attardi LD, Lloyd TE, Ichida JK, Gao FB, Greenleaf WJ, Yokoyama JS, Petrucelli L, Gitler AD. PMID: 33482083; PMCID: PMC7886018.
      View in: PubMed   Mentions: 74     Fields:    Translation:AnimalsCells
    27. The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease. Neurobiol Dis. 2021 02; 149:105228. Bakkar N, Starr A, Rabichow BE, Lorenzini I, McEachin ZT, Kraft R, Chaung M, Macklin-Isquierdo S, Wingfield T, Carhart B, Zahler N, Chang WH, Bassell GJ, Betourne A, Boulis N, Alworth SV, Ichida JK, August PR, Zarnescu DC, Sattler R, Bowser R. PMID: 33359139; PMCID: PMC9676097.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    28. Protocol for Differentiation of Human iPSCs into Pulmonary Neuroendocrine Cells. STAR Protoc. 2020 09 18; 1(2):100068. Hor P, Ichida JK, Borok Z, Ryan AL. PMID: 33111106; PMCID: PMC7580194.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    29. Generation of inner ear hair cells by direct lineage conversion of primary somatic cells. Elife. 2020 06 30; 9. Menendez L, Trecek T, Gopalakrishnan S, Tao L, Markowitz AL, Yu HV, Wang X, Llamas J, Huang C, Lee J, Kalluri R, Ichida J, Segil N. PMID: 32602462; PMCID: PMC7326493.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    30. Efficient Generation and Transcriptomic Profiling of Human iPSC-Derived Pulmonary Neuroendocrine Cells. iScience. 2020 May 22; 23(5):101083. Hor P, Punj V, Calvert BA, Castaldi A, Miller AJ, Carraro G, Stripp BR, Brody SL, Spence JR, Ichida JK, Ryan Firth AL, Borok Z. PMID: 32380423; PMCID: PMC7205764.
      View in: PubMed   Mentions: 15  
    31. Organoids Develop Motor Skills: 3D Human Neuromuscular Junctions. Cell Stem Cell. 2020 02 06; 26(2):131-133. Ichida JK, Ko CP. PMID: 32032521.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. 2019 Nov; 138(5):883-884. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. PMID: 31559488.
      View in: PubMed   Mentions:    Fields:    
    33. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 11 12; 13(5):939-955. Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S, Tau Consortium Stem Cell Group. PMID: 31631020; PMCID: PMC6895712.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    34. C9ORF72 protein function and immune dysregulation in amyotrophic lateral sclerosis. Neurosci Lett. 2019 11 20; 713:134523. Lai JD, Ichida JK. PMID: 31568865.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    35. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming. Cell Stem Cell. 2019 10 03; 25(4):486-500.e9. Babos KN, Galloway KE, Kisler K, Zitting M, Li Y, Shi Y, Quintino B, Chow RH, Zlokovic BV, Ichida JK. PMID: 31523028; PMCID: PMC6778044.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    36. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nat Neurosci. 2019 09; 22(9):1383-1388. Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, Partridge L, Ichida JK, Isaacs AM, Petrucelli L, Gitler AD. PMID: 31358992; PMCID: PMC6713615.
      View in: PubMed   Mentions: 48     Fields:    
    37. Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons. JCI Insight. 2019 07 16; 5. Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK. PMID: 31310593; PMCID: PMC6693831.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    38. Directly Reprogrammed Neurons Still Have Some Growing Up to Do. Cell Stem Cell. 2019 07 03; 25(1):1-2. Li Y, Ichida JK. PMID: 31271745.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. 2019 07; 138(1):49-65. Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K, Sattler R. PMID: 30945056; PMCID: PMC6750285.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    40. Comparative genomic analysis of embryonic, lineage-converted and stem cell-derived motor neurons. Development. 2018 11 21; 145(22). Ichida JK, Staats KA, Davis-Dusenbery BN, Clement K, Galloway KE, Babos KN, Shi Y, Son EY, Kiskinis E, Atwater N, Gu H, Gnirke A, Meissner A, Eggan K. PMID: 30337375; PMCID: PMC6262794.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    41. Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. Biol Psychiatry. 2019 02 15; 85(4):305-316. Wilkinson B, Evgrafov OV, Zheng D, Hartel N, Knowles JA, Graham NA, Ichida JK, Coba MP. PMID: 29961565; PMCID: PMC6251761.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    42. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nat Genet. 2018 04; 50(4):603-612. Kramer NJ, Haney MS, Morgens DW, Jovicic A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, Gitler AD. PMID: 29507424; PMCID: PMC5893388.
      View in: PubMed   Mentions: 110     Fields:    Translation:HumansAnimalsCells
    43. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nat Med. 2018 03; 24(3):313-325. Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK. PMID: 29400714; PMCID: PMC6112156.
      View in: PubMed   Mentions: 278     Fields:    Translation:HumansAnimalsCells
    44. Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI Insight. 2017 11 16; 2(22). Patten SA, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong GA, La Fontaine A, Maios C, Liao M, Ciura S, Wen XY, Rafuse V, Ichida J, Zinman L, Julien JP, Kabashi E, Robitaille R, Korngut L, Parker JA, Drapeau P. PMID: 29202456; PMCID: PMC5752378.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
    45. Human Induced Pluripotent Stem Cell-Derived Motor Neuron Transplant for Neuromuscular Atrophy in a Mouse Model of Sciatic Nerve Injury. JAMA Facial Plast Surg. 2017 May 01; 19(3):197-205. Pepper JP, Wang TV, Hennes V, Sun SY, Ichida JK. PMID: 27978547; PMCID: PMC5815137.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    46. Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 09; 35(3):358-65. Askary A, Mork L, Paul S, He X, Izuhara AK, Gopalakrishnan S, Ichida JK, McMahon AP, Dabizljevic S, Dale R, Mariani FV, Crump JG. PMID: 26555055; PMCID: PMC4758819.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    47. New approaches for direct conversion of patient fibroblasts into neural cells. Brain Res. 2017 02 01; 1656:2-13. Gopalakrishnan S, Hor P, Ichida JK. PMID: 26475975; PMCID: PMC4834061.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    48. Small Molecules Take a Big Step by Converting Fibroblasts into Neurons. Cell Stem Cell. 2015 Aug 06; 17(2):127-9. Babos K, Ichida JK. PMID: 26253195.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2015 Jul; 18(7):978-87. Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV. PMID: 26005850; PMCID: PMC4482781.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    50. Probing disorders of the nervous system using reprogramming approaches. EMBO J. 2015 Jun 03; 34(11):1456-77. Ichida JK, Kiskinis E. PMID: 25925386; PMCID: PMC4474524.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    51. Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons. J Neurosci. 2015 Jan 21; 35(3):1291-306. Toma JS, Shettar BC, Chipman PH, Pinto DM, Borowska JP, Ichida JK, Fawcett JP, Zhang Y, Eggan K, Rafuse VF. PMID: 25609642; PMCID: PMC4402330.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    52. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 2014 Dec 17; 84(6):1213-25. Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. PMID: 25521377; PMCID: PMC4632245.
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    53. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. PMID: 25420066; PMCID: PMC4429606.
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    54. Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol. 2014 Aug; 10(8):632-639. Ichida JK, Tcw J, Williams LA, Carter AC, Shi Y, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. PMID: 24952596; PMCID: PMC4310751.
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    55. Ketamine exposure in early development impairs specification of the primary germ cell layers. Neurotoxicol Teratol. 2014 May-Jun; 43:59-68. Akeju O, Davis-Dusenbery BN, Cassel SH, Ichida JK, Eggan K. PMID: 24746641; PMCID: PMC4046705.
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    56. Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1. Cell Stem Cell. 2014 Jun 05; 14(6):781-95. Kiskinis E, Sandoe J, Williams LA, Boulting GL, Moccia R, Wainger BJ, Han S, Peng T, Thams S, Mikkilineni S, Mellin C, Merkle FT, Davis-Dusenbery BN, Ziller M, Oakley D, Ichida J, Di Costanzo S, Atwater N, Maeder ML, Goodwin MJ, Nemesh J, Handsaker RE, Paull D, Noggle S, McCarroll SA, Joung JK, Woolf CJ, Brown RH, Eggan K. PMID: 24704492; PMCID: PMC4653065.
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    57. Nanog-independent reprogramming to iPSCs with canonical factors. Stem Cell Reports. 2014 Feb 11; 2(2):119-26. Carter AC, Davis-Dusenbery BN, Koszka K, Ichida JK, Eggan K. PMID: 24527385; PMCID: PMC3923195.
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    58. Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies. Cell Reprogram. 2013 Dec; 15(6):495-502. Navara CS, Hornecker J, Grow D, Chaudhari S, Hornsby PJ, Ichida JK, Eggan K, McCarrey JR. PMID: 24182315; PMCID: PMC3848439.
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    59. β-catenin functions pleiotropically in differentiation and tumorigenesis in mouse embryo-derived stem cells. PLoS One. 2013; 8(5):e63265. Okumura N, Akutsu H, Sugawara T, Miura T, Takezawa Y, Hosoda A, Yoshida K, Ichida JK, Yamada M, Hamatani T, Kuji N, Miyado K, Yoshimura Y, Umezawa A. PMID: 23691006; PMCID: PMC3653942.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    60. CLP1 links tRNA metabolism to progressive motor-neuron loss. Nature. 2013 Mar 28; 495(7442):474-80. Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM. PMID: 23474986; PMCID: PMC3674495.
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    61. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. PMID: 21971503; PMCID: PMC3335196.
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    62. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 02; 9(3):205-18. Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. PMID: 21852222; PMCID: PMC3188987.
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    63. Shushing down the epigenetic landscape towards stem cell differentiation. Development. 2010 Aug 01; 137(15):2455-60. Ichida JK, Kiskinis E, Eggan K. PMID: 20554719.
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    64. Effect of stalling after mismatches on the error catastrophe in nonenzymatic nucleic acid replication. J Am Chem Soc. 2010 Apr 28; 132(16):5880-5. Rajamani S, Ichida JK, Antal T, Treco DA, Leu K, Nowak MA, Szostak JW, Chen IA. PMID: 20359213; PMCID: PMC2857888.
      View in: PubMed   Mentions: 56     Fields:    Translation:Cells
    65. A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog. Cell Stem Cell. 2009 Nov 06; 5(5):491-503. Ichida JK, Blanchard J, Lam K, Son EY, Chung JE, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu DR, Rubin LL, Eggan K. PMID: 19818703; PMCID: PMC3335195.
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    66. Elucidating nuclear reprogramming mechanisms: taking a synergistic approach. Reprod Biomed Online. 2008 Jan; 16(1):41-50. Sullivan S, Ichida JK, Umezawa A, Akutsu H. PMID: 18252046.
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    67. DNA polymerase-mediated DNA synthesis on a TNA template. J Am Chem Soc. 2003 Jan 29; 125(4):856-7. Chaput JC, Ichida JK, Szostak JW. PMID: 12537469.
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