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Gage Dekoeyer Crump, PhD

TitleProfessor of Stem Cell & Regenerative Medicine
InstitutionUniversity of Southern California
DepartmentStem Cell Biology & Regenerative Medicine
AddressBCC 406 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2693
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    Other Positions
    TitleDirector, DSR PhD Program


    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Progenitor Regulation in Craniofacial Development and Regeneration
    NIH/NIDCR R35DE027550Sep 14, 2017 - Jun 30, 2025
    Role: Principal Investigator
    Molecular and Cellular Basis of Craniosynostosis
    NIH/NIDCR R01DE026339Jul 1, 2016 - Mar 31, 2021
    Role: Co-Investigator
    Role of Ossifying Chondrocytes in Regeneration of the Adult Jaw Skeleton
    NIH/NIDCR R21DE023899Sep 1, 2014 - Aug 30, 2016
    Role: Principal Investigator
    Molecular and Cellular Basis of Pharyngeal Pouch Development
    NIH/NIDCR R01DE022572Jul 18, 2013 - May 31, 2018
    Role: Principal Investigator
    Training in Developmental Biology, Stem Cells and Regeneration
    NIH/NICHD T32HD060549May 1, 2011 - Apr 30, 2022
    Role: Principal Investigator
    Epithelial-mesenchymal interactions in facial patterning
    NIH/NIDCR R01DE018405Sep 1, 2007 - Mar 31, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Duong TB, Ravisankar P, Song YC, Gafranek JT, Rydeen AB, Dohn TE, Barske LA, Crump G, Waxman JS. Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms. Dev Biol. 2018 Feb 01; 434(1):7-14. PMID: 29157563.
      View in: PubMed
    2. Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump G, Dong PDS. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017 10 03; 8(1):769. PMID: 28974684.
      View in: PubMed
    3. Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump G, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. PMID: 28783163.
      View in: PubMed
    4. Askary A, Xu P, Barske L, Bay M, Bump P, Balczerski B, Bonaguidi MA, Crump G. Genome-wide analysis of facial skeletal regionalization in zebrafish. Development. 2017 08 15; 144(16):2994-3005. PMID: 28705894.
      View in: PubMed
    5. Teng CS, Yen HY, Barske L, Smith B, Llamas J, Segil N, Go J, Sanchez-Lara PA, Maxson RE, Crump G. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017 May 31; 7(1):2497. PMID: 28566723.
      View in: PubMed
    6. Paul S, Crump G. Lessons on skeletal cell plasticity from studying jawbone regeneration in zebrafish. Bonekey Rep. 2016; 5:853. PMID: 27867499.
      View in: PubMed
    7. Smeeton J, Askary A, Crump G. Building and maintaining joints by exquisite local control of cell fate. Wiley Interdiscip Rev Dev Biol. 2017 01; 6(1). PMID: 27581688.
      View in: PubMed
    8. Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis NA, Postlethwait J, Miller CT, Crump G. Ancient origin of lubricated joints in bony vertebrates. Elife. 2016 07 19; 5. PMID: 27434666.
      View in: PubMed
    9. Paul S, Schindler S, Giovannone D, de Millo Terrazzani A, Mariani FV, Crump G. Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development. 2016 06 15; 143(12):2066-76. PMID: 27122168; PMCID: PMC4920169 [Available on 06/15/17].
    10. Barske L, Askary A, Zuniga E, Balczerski B, Bump P, Nichols JT, Crump G. Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet. 2016 Apr; 12(4):e1005967. PMID: 27058748; PMCID: PMC4825933.
    11. Askary A, Mork L, Paul S, He X, Izuhara AK, Gopalakrishnan S, Ichida JK, McMahon AP, Dabizljevic S, Dale R, Mariani FV, Crump G. Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 09; 35(3):358-65. PMID: 26555055; PMCID: PMC4758819 [Available on 11/09/16].
    12. Mork L, Crump G. Zebrafish Craniofacial Development: A Window into Early Patterning. Curr Top Dev Biol. 2015; 115:235-69. PMID: 26589928; PMCID: PMC4758817.
    13. Choe CP, Crump G. Dynamic epithelia of the developing vertebrate face. Curr Opin Genet Dev. 2015 Jun; 32:66-72. PMID: 25748249; PMCID: PMC4470803.
    14. Choe CP, Crump G. Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development. 2015 Mar 15; 142(6):1089-94. PMID: 25725065; PMCID: PMC4360181.
    15. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump G, Traver D. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. PMID: 25230933; PMCID: PMC4253525.
    16. Choe CP, Crump G. Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a. Development. 2014 Sep; 141(18):3583-93. PMID: 25142463; PMCID: PMC4197720.
    17. Choe CP, Collazo A, Trinh le A, Pan L, Moens CB, Crump G. Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013 Feb 11; 24(3):296-309. PMID: 23375584; PMCID: PMC3656592.
    18. Heur M, Jiao S, Schindler S, Crump G. Regenerative potential of the zebrafish corneal endothelium. Exp Eye Res. 2013 Jan; 106:1-4. PMID: 23108006; PMCID: PMC3538902.
    19. Cox SG, Kim H, Garnett AT, Medeiros DM, An W, Crump G. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012 Sep; 8(9):e1002938. PMID: 23028350; PMCID: PMC3447937.
    20. Medeiros DM, Crump G. New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw. Dev Biol. 2012 Nov 15; 371(2):121-35. PMID: 22960284; PMCID: PMC3466404.
    21. Witzel HR, Jungblut B, Choe CP, Crump G, Braun T, Dobreva G. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell. 2012 Jul 17; 23(1):58-70. PMID: 22771034; PMCID: PMC3671491.
    22. Das A, Crump G. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012; 8(5):e1002710. PMID: 22589745; PMCID: PMC3349740.
    23. Balczerski B, Matsutani M, Castillo P, Osborne N, Stainier DY, Crump G. Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. Dev Biol. 2012 Feb 15; 362(2):230-41. PMID: 22185793; PMCID: PMC3265674.
    24. Alexander C, Zuniga E, Blitz IL, Wada N, Le Pabic P, Javidan Y, Zhang T, Cho KW, Crump G, Schilling TF. Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development. 2011 Dec; 138(23):5135-46. PMID: 22031543; PMCID: PMC3210495.
    25. Zuniga E, Rippen M, Alexander C, Schilling TF, Crump G. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 2011 Dec; 138(23):5147-56. PMID: 22031546; PMCID: PMC3210496.
    26. Lou X, Deshwar AR, Crump G, Scott IC. Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development. 2011 Aug; 138(15):3113-23. PMID: 21715426.
      View in: PubMed
    27. Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump G, Hozumi K, Yonemura S, Kawakami K, Itoh M. Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development. 2010 Aug 01; 137(15):2527-37. PMID: 20573700; PMCID: PMC2927672.
    28. Zuniga E, Stellabotte F, Crump G. Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development. 2010 Jun; 137(11):1843-52. PMID: 20431122; PMCID: PMC2867320.
    29. Laue K, Daujat S, Crump G, Plaster N, Roehl HH. The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development. 2008 Jun; 135(11):1935-46. PMID: 18469222; PMCID: PMC2919486.
    30. Patel MR, Lehrman EK, Poon VY, Crump G, Zhen M, Bargmann CI, Shen K. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci. 2006 Dec; 9(12):1488-98. PMID: 17115039; PMCID: PMC3917495.
    31. Crump G, Swartz ME, Eberhart JK, Kimmel CB. Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development. 2006 Jul; 133(14):2661-9. PMID: 16774997.
      View in: PubMed
    32. Eberhart JK, Swartz ME, Crump G, Kimmel CB. Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development. 2006 Mar; 133(6):1069-77. PMID: 16481351.
      View in: PubMed
    33. Kishi M, Pan YA, Crump G, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11; 307(5711):929-32. PMID: 15705853.
      View in: PubMed
    34. Yan YL, Willoughby J, Liu D, Crump G, Wilson C, Miller CT, Singer A, Kimmel C, Westerfield M, Postlethwait JH. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 2005 Mar; 132(5):1069-83. PMID: 15689370.
      View in: PubMed
    35. Crump G, Maves L, Lawson ND, Weinstein BM, Kimmel CB. An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development. 2004 Nov; 131(22):5703-16. PMID: 15509770.
      View in: PubMed
    36. Crump G, Swartz ME, Kimmel CB. An integrin-dependent role of pouch endoderm in hyoid cartilage development. PLoS Biol. 2004 Sep; 2(9):E244. PMID: 15269787; PMCID: PMC479042.
    37. Kimmel CB, Ullmann B, Walker M, Miller CT, Crump G. Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development. 2003 Apr; 130(7):1339-51. PMID: 12588850.
      View in: PubMed
    38. Dwyer ND, Adler CE, Crump G, L'Etoile ND, Bargmann CI. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron. 2001 Aug 02; 31(2):277-87. PMID: 11502258.
      View in: PubMed
    39. Crump G, Zhen M, Jin Y, Bargmann CI. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Neuron. 2001 Jan; 29(1):115-29. PMID: 11182085.
      View in: PubMed
    40. Roayaie K, Crump G, Sagasti A, Bargmann CI. The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron. 1998 Jan; 20(1):55-67. PMID: 9459442.
      View in: PubMed
    41. Chou JH, Troemel ER, Sengupta P, Colbert HA, Tong L, Tobin DM, Roayaie K, Crump G, Dwyer ND, Bargmann CI. Olfactory recognition and discrimination in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1996; 61:157-64. PMID: 9246444.
      View in: PubMed
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