Gage Dekoeyer Crump, PhD

Title(s)Professor of Stem Cell & Regenerative Medicine
SchoolKeck School of Medicine of Usc
AddressBCC 406 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2693
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    Other Positions
    Title(s)Director, DSR PhD Program

    Title(s)Vice Chair, Department of Stem Cell Biology and Regenerative Medicine

    Title(s)Interim Chair of Stem Cell Biology and Regenerative Medicine


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    Modular control of jaw tendon specification by the Nr5a2 orphan nuclear receptor
    NIH R21DE029656Mar 1, 2020 - Feb 28, 2022
    Role: Principal Investigator
    Progenitor Regulation in Craniofacial Development and Regeneration
    NIH R35DE027550Sep 14, 2017 - Jun 30, 2025
    Role: Principal Investigator
    Molecular and Cellular Basis of Craniosynostosis
    NIH R01DE026339Jul 1, 2016 - Jul 31, 2026
    Role: Co-Investigator
    Role of Ossifying Chondrocytes in Regeneration of the Adult Jaw Skeleton
    NIH R21DE023899Sep 1, 2014 - Aug 30, 2016
    Role: Principal Investigator
    Molecular and Cellular Basis of Pharyngeal Pouch Development
    NIH R01DE022572Jul 18, 2013 - May 31, 2018
    Role: Principal Investigator
    Training in Developmental Biology, Stem Cells and Regeneration
    NIH T32HD060549May 1, 2011 - Apr 30, 2022
    Role: Principal Investigator
    Epithelial-mesenchymal interactions in facial patterning
    NIH R01DE018405Sep 1, 2007 - Mar 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biol Open. 2021 02 25; 10(2). Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G, Gill PS. PMID: 32694189; PMCID: PMC7928229.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    2. Evolution of vertebrate gill covers via shifts in an ancient Pou3f3 enhancer. Proc Natl Acad Sci U S A. 2020 10 06; 117(40):24876-24884. Barske L, Fabian P, Hirschberger C, Jandzik D, Square T, Xu P, Nelson N, Yu HV, Medeiros DM, Gillis JA, Crump JG. PMID: 32958671; PMCID: PMC7547273.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    3. Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms. Dev Biol. 2018 02 01; 434(1):7-14. Duong TB, Ravisankar P, Song YC, Gafranek JT, Rydeen AB, Dohn TE, Barske LA, Crump JG, Waxman JS. PMID: 29157563; PMCID: PMC5785549.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    4. Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nat Commun. 2017 10 03; 8(1):769. Zhang D, Gates KP, Barske L, Wang G, Lancman JJ, Zeng XI, Groff M, Wang K, Parsons MJ, Crump JG, Dong PDS. PMID: 28974684; PMCID: PMC5626745.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    5. Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration. Nat Genet. 2017 Sep; 49(9):1346-1353. Patterson M, Barske L, Van Handel B, Rau CD, Gan P, Sharma A, Parikh S, Denholtz M, Huang Y, Yamaguchi Y, Shen H, Allayee H, Crump JG, Force TI, Lien CL, Makita T, Lusis AJ, Kumar SR, Sucov HM. PMID: 28783163; PMCID: PMC5736145.
      View in: PubMed   Mentions: 164     Fields:    Translation:AnimalsCells
    6. Genome-wide analysis of facial skeletal regionalization in zebrafish. Development. 2017 08 15; 144(16):2994-3005. Askary A, Xu P, Barske L, Bay M, Bump P, Balczerski B, Bonaguidi MA, Crump JG. PMID: 28705894; PMCID: PMC5592815.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    7. Requirement for Jagged1-Notch2 signaling in patterning the bones of the mouse and human middle ear. Sci Rep. 2017 05 31; 7(1):2497. Teng CS, Yen HY, Barske L, Smith B, Llamas J, Segil N, Go J, Sanchez-Lara PA, Maxson RE, Crump JG. PMID: 28566723; PMCID: PMC5451394.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    8. Lessons on skeletal cell plasticity from studying jawbone regeneration in zebrafish. Bonekey Rep. 2016; 5:853. Paul S, Crump JG. PMID: 27867499; PMCID: PMC5111230.
      View in: PubMed   Mentions: 6  
    9. Building and maintaining joints by exquisite local control of cell fate. Wiley Interdiscip Rev Dev Biol. 2017 01; 6(1). Smeeton J, Askary A, Crump JG. PMID: 27581688; PMCID: PMC5877473.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    10. Ancient origin of lubricated joints in bony vertebrates. Elife. 2016 07 19; 5. Askary A, Smeeton J, Paul S, Schindler S, Braasch I, Ellis NA, Postlethwait J, Miller CT, Crump JG. PMID: 27434666; PMCID: PMC4951194.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    11. Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development. 2016 06 15; 143(12):2066-76. Paul S, Schindler S, Giovannone D, de Millo Terrazzani A, Mariani FV, Crump JG. PMID: 27122168; PMCID: PMC4920169.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    12. Competition between Jagged-Notch and Endothelin1 Signaling Selectively Restricts Cartilage Formation in the Zebrafish Upper Face. PLoS Genet. 2016 Apr; 12(4):e1005967. Barske L, Askary A, Zuniga E, Balczerski B, Bump P, Nichols JT, Crump JG. PMID: 27058748; PMCID: PMC4825933.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    13. Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell. 2015 Nov 09; 35(3):358-65. Askary A, Mork L, Paul S, He X, Izuhara AK, Gopalakrishnan S, Ichida JK, McMahon AP, Dabizljevic S, Dale R, Mariani FV, Crump JG. PMID: 26555055; PMCID: PMC4758819.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    14. Zebrafish Craniofacial Development: A Window into Early Patterning. Curr Top Dev Biol. 2015; 115:235-69. Mork L, Crump G. PMID: 26589928; PMCID: PMC4758817.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    15. Dynamic epithelia of the developing vertebrate face. Curr Opin Genet Dev. 2015 Jun; 32:66-72. Choe CP, Crump JG. PMID: 25748249; PMCID: PMC4470803.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    16. Eph-Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics. Development. 2015 Mar 15; 142(6):1089-94. Choe CP, Crump JG. PMID: 25725065; PMCID: PMC4360181.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    17. Discrete Notch signaling requirements in the specification of hematopoietic stem cells. EMBO J. 2014 Oct 16; 33(20):2363-73. Kim AD, Melick CH, Clements WK, Stachura DL, Distel M, Panáková D, MacRae C, Mork LA, Crump JG, Traver D. PMID: 25230933; PMCID: PMC4253525.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    18. Tbx1 controls the morphogenesis of pharyngeal pouch epithelia through mesodermal Wnt11r and Fgf8a. Development. 2014 Sep; 141(18):3583-93. Choe CP, Crump JG. PMID: 25142463; PMCID: PMC4197720.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    19. Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013 Feb 11; 24(3):296-309. Choe CP, Collazo A, Trinh le A, Pan L, Moens CB, Crump JG. PMID: 23375584; PMCID: PMC3656592.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    20. Regenerative potential of the zebrafish corneal endothelium. Exp Eye Res. 2013 Jan; 106:1-4. Heur M, Jiao S, Schindler S, Crump JG. PMID: 23108006; PMCID: PMC3538902.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    21. An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012 Sep; 8(9):e1002938. Cox SG, Kim H, Garnett AT, Medeiros DM, An W, Crump JG. PMID: 23028350; PMCID: PMC3447937.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    22. New perspectives on pharyngeal dorsoventral patterning in development and evolution of the vertebrate jaw. Dev Biol. 2012 Nov 15; 371(2):121-35. Medeiros DM, Crump JG. PMID: 22960284; PMCID: PMC3466404.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    23. The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell. 2012 Jul 17; 23(1):58-70. Witzel HR, Jungblut B, Choe CP, Crump JG, Braun T, Dobreva G. PMID: 22771034; PMCID: PMC3671491.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    24. Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012; 8(5):e1002710. Das A, Crump JG. PMID: 22589745; PMCID: PMC3349740.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    25. Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. Dev Biol. 2012 Feb 15; 362(2):230-41. Balczerski B, Matsutani M, Castillo P, Osborne N, Stainier DY, Crump JG. PMID: 22185793; PMCID: PMC3265674.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    26. Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development. 2011 Dec; 138(23):5135-46. Alexander C, Zuniga E, Blitz IL, Wada N, Le Pabic P, Javidan Y, Zhang T, Cho KW, Crump JG, Schilling TF. PMID: 22031543; PMCID: PMC3210495.
      View in: PubMed   Mentions: 76     Fields:    Translation:AnimalsCells
    27. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 2011 Dec; 138(23):5147-56. Zuniga E, Rippen M, Alexander C, Schilling TF, Crump JG. PMID: 22031546; PMCID: PMC3210496.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    28. Smarcd3b and Gata5 promote a cardiac progenitor fate in the zebrafish embryo. Development. 2011 Aug; 138(15):3113-23. Lou X, Deshwar AR, Crump JG, Scott IC. PMID: 21715426.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    29. Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. Development. 2010 Aug 01; 137(15):2527-37. Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M. PMID: 20573700; PMCID: PMC2927672.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    30. Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development. 2010 Jun; 137(11):1843-52. Zuniga E, Stellabotte F, Crump JG. PMID: 20431122; PMCID: PMC2867320.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    31. The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity. Development. 2008 Jun; 135(11):1935-46. Laue K, Daujat S, Crump JG, Plaster N, Roehl HH, Tübingen 2000 Screen Consortium, Kimmel CB, Schneider R, Hammerschmidt M. PMID: 18469222; PMCID: PMC2919486.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    32. Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nat Neurosci. 2006 Dec; 9(12):1488-98. Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI, Shen K. PMID: 17115039; PMCID: PMC3917495.
      View in: PubMed   Mentions: 101     Fields:    Translation:AnimalsCells
    33. Moz-dependent Hox expression controls segment-specific fate maps of skeletal precursors in the face. Development. 2006 Jul; 133(14):2661-9. Crump JG, Swartz ME, Eberhart JK, Kimmel CB. PMID: 16774997.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    34. Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development. 2006 Mar; 133(6):1069-77. Eberhart JK, Swartz ME, Crump JG, Kimmel CB. PMID: 16481351.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    35. Mammalian SAD kinases are required for neuronal polarization. Science. 2005 Feb 11; 307(5711):929-32. Kishi M, Pan YA, Crump JG, Sanes JR. PMID: 15705853.
      View in: PubMed   Mentions: 157     Fields:    Translation:AnimalsCells
    36. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development. 2005 Mar; 132(5):1069-83. Yan YL, Willoughby J, Liu D, Crump JG, Wilson C, Miller CT, Singer A, Kimmel C, Westerfield M, Postlethwait JH. PMID: 15689370.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    37. An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development. 2004 Nov; 131(22):5703-16. Crump JG, Maves L, Lawson ND, Weinstein BM, Kimmel CB. PMID: 15509770.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    38. An integrin-dependent role of pouch endoderm in hyoid cartilage development. PLoS Biol. 2004 Sep; 2(9):E244. Crump JG, Swartz ME, Kimmel CB. PMID: 15269787; PMCID: PMC479042.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    39. Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish. Development. 2003 Apr; 130(7):1339-51. Kimmel CB, Ullmann B, Walker M, Miller CT, Crump JG. PMID: 12588850.
      View in: PubMed   Mentions: 55     Fields:    Translation:Animals
    40. Polarized dendritic transport and the AP-1 mu1 clathrin adaptor UNC-101 localize odorant receptors to olfactory cilia. Neuron. 2001 Aug 02; 31(2):277-87. Dwyer ND, Adler CE, Crump JG, L'Etoile ND, Bargmann CI. PMID: 11502258.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    41. The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination. Neuron. 2001 Jan; 29(1):115-29. Crump JG, Zhen M, Jin Y, Bargmann CI. PMID: 11182085.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    42. The G alpha protein ODR-3 mediates olfactory and nociceptive function and controls cilium morphogenesis in C. elegans olfactory neurons. Neuron. 1998 Jan; 20(1):55-67. Roayaie K, Crump JG, Sagasti A, Bargmann CI. PMID: 9459442.
      View in: PubMed   Mentions: 136     Fields:    Translation:AnimalsCells
    43. Olfactory recognition and discrimination in Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol. 1996; 61:157-64. Chou JH, Troemel ER, Sengupta P, Colbert HA, Tong L, Tobin DM, Roayaie K, Crump JG, Dwyer ND, Bargmann CI. PMID: 9246444.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
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