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Promoter hypermethylation as a novel regulator of ANO1 expression and function in prostate cancer bone metastasis. Sci Rep. 2024 05 21; 14(1):11595.
Shin Y, Kim S, An W. PMID: 38773164; PMCID: PMC11109272.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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MMP-9-dependent proteolysis of the histone H3 N-terminal tail: a critical epigenetic step in driving oncogenic transcription and colon tumorigenesis. Mol Oncol. 2024 Aug; 18(8):2001-2019.
Shin Y, Kim S, Liang G, An W. PMID: 38600695; PMCID: PMC11306514.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Non-canonical MLL1 activity regulates centromeric phase separation and genome stability. Nat Cell Biol. 2023 Nov; 25(11):1637-1649.
Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz HJ, An W, Cho US, Dou Y. PMID: 37945831; PMCID: PMC11345869.
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PubMed Mentions:
5 Fields:
Translation:
HumansCells
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VprBP/DCAF1 Triggers Melanomagenic Gene Silencing through Histone H2A Phosphorylation. Biomedicines. 2023 Sep 17; 11(9).
Shin Y, Kim S, Liang G, Ulmer TS, An W. PMID: 37760992; PMCID: PMC10526264.
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PubMed Mentions:
2
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Phosphorylation and stabilization of EZH2 by DCAF1/VprBP trigger aberrant gene silencing in colon cancer. Nat Commun. 2023 04 17; 14(1):2140.
Ghate NB, Kim S, Shin Y, Kim J, Doche M, Valena S, Situ A, Kim S, Rhie SK, Lenz HJ, Ulmer TS, Mumenthaler SM, An W. PMID: 37069142; PMCID: PMC10110550.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
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VprBP/DCAF1 regulates p53 function and stability through site-specific phosphorylation. Oncogene. 2023 04; 42(17):1405-1416.
Ghate NB, Kim S, Mehmood R, Shin Y, Kim K, An W. PMID: 37041410; PMCID: PMC10121470.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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DNMT and EZH2 inhibitors synergize to activate therapeutic targets in hepatocellular carcinoma. Cancer Lett. 2022 11 01; 548:215899.
Zhang L, Li HT, Shereda R, Lu Q, Weisenberger DJ, O'Connell C, Machida K, An W, Lenz HJ, El-Khoueiry A, Jones PA, Liu M, Liang G. PMID: 36087682; PMCID: PMC9563073.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansCells
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MMP-9 drives the melanomagenic transcription program through histone H3 tail proteolysis. Oncogene. 2022 01; 41(4):560-570.
Shin Y, Kim S, Ghate NB, Rhie SK, An W. PMID: 34785776.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
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VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer. Mol Oncol. 2021 10; 15(10):2801-2817.
Ghate NB, Kim S, Spiller E, Kim S, Shin Y, Rhie SK, Smbatyan G, Lenz HJ, Mumenthaler SM, An W. PMID: 34312968; PMCID: PMC8486565.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
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MMP-2 is a novel histone H3 N-terminal protease necessary for myogenic gene activation. Epigenetics Chromatin. 2021 05 17; 14(1):23.
Rice JC, Weekley BH, Kanholm T, Chen Z, Lee S, Fernandez DJ, Abrahamson R, Castaldi A, Borok Z, Dynlacht BD, An W. PMID: 34001241; PMCID: PMC8130154.
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PubMed Mentions:
8 Fields:
Translation:
Animals
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Insight Into Pathological Integrin αIIbβ3 Activation From Safeguarding The Inactive State. J Mol Biol. 2021 04 02; 433(7):166832.
Situ AJ, Kim J, An W, Kim C, Ulmer TS. PMID: 33539882; PMCID: PMC11025565.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes. Genome Res. 2020 02; 30(2):155-163.
Zhang L, He A, Chen B, Bi J, Chen J, Guo D, Qian Y, Wang W, Shi T, Zhao Z, Shi J, An W, Attenello F, Lu W. PMID: 31953347; PMCID: PMC7050528.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansCells
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Epigenetic Modification as a Regulatory Mechanism for Spatiotemporal Dynamics of ANO1 Expression in Salivary Glands. Int J Mol Sci. 2019 Dec 13; 20(24).
Shin Y, Lee SW, Namkoong E, An W, Lee JH, Brown PD, Park K. PMID: 31847128; PMCID: PMC6940850.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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p32 is a negative regulator of p53 tetramerization and transactivation. Mol Oncol. 2019 09; 13(9):1976-1992.
Ghate NB, Kim J, Shin Y, Situ A, Ulmer TS, An W. PMID: 31293051; PMCID: PMC6717765.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansCells
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DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis. Epigenetics Chromatin. 2019 04 16; 12(1):25.
Shin Y, Ghate NB, Moon B, Park K, Lu W, An W. PMID: 30992059; PMCID: PMC6466663.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3. Cell Rep. 2018 07 03; 24(1):224-237.
Kim J, Shin Y, Lee S, Kim M, Punj V, Lu JF, Shin H, Kim K, Ulmer TS, Koh J, Jeong D, An W. PMID: 29972783; PMCID: PMC6061927.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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MacroH2A1.2 inhibits prostate cancer-induced osteoclastogenesis through cooperation with HP1α and H1.2. Oncogene. 2018 10; 37(43):5749-5765.
Kim JM, Shin Y, Lee S, Kim MY, Punj V, Shin HI, Kim K, Koh JM, Jeong D, An W. PMID: 29925860; PMCID: PMC6309402.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis. Epigenetics Chromatin. 2018 05 28; 11(1):23.
Kim K, Shin Y, Kim J, Ulmer TS, An W. PMID: 29807539; PMCID: PMC5971420.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Membrane Anchoring of α-Helical Proteins: Role of Tryptophan. J Phys Chem B. 2018 01 25; 122(3):1185-1194.
Situ AJ, Kang SM, Frey BB, An W, Kim C, Ulmer TS. PMID: 29323921; PMCID: PMC11025564.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing. Proc Natl Acad Sci U S A. 2017 09 19; 114(38):E7949-E7958.
Zhang Z, Jones AE, Wu W, Kim J, Kang Y, Bi X, Gu Y, Popov IK, Renfrow MB, Vassylyeva MN, Vassylyev DG, Giles KE, Chen D, Kumar A, Fan Y, Tong Y, Liu CF, An W, Chang C, Luo J, Chow LT, Wang H. PMID: 28855339; PMCID: PMC5617306.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Correction for Kim et al., "Vpr-Binding Protein Antagonizes p53-Mediated Transcription via Direct Interaction with H3 Tail". Mol Cell Biol. 2017 08 01; 37(15).
Kim K, Heo K, Choi J, Jackson S, Kim H, Xiong Y, An W. PMID: 28710123; PMCID: PMC5514449.
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PubMed Mentions: Fields:
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A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 08 19; 291(34):17536-46.
Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS. PMID: 27365391; PMCID: PMC5016151.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19.
Kim K, Punj V, Kim JM, Lee S, Ulmer TS, Lu W, Rice JC, An W. PMID: 26744418; PMCID: PMC4719310.
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PubMed Mentions:
57 Fields:
Translation:
AnimalsCells
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Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714.
Kim JM, Kim K, Punj V, Liang G, Ulmer TS, Lu W, An W. PMID: 26581166; PMCID: PMC4652225.
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PubMed Mentions:
28 Fields:
Translation:
HumansCells
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Analysis of a transgenic Oct4 enhancer reveals high fidelity long-range chromosomal interactions. Sci Rep. 2015 Oct 05; 5:14558.
Cai M, Gao F, Zhang P, An W, Shi J, Wang K, Lu W. PMID: 26435056; PMCID: PMC4592970.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83.
Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer TS, An W. PMID: 26350217; PMCID: PMC4605318.
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PubMed Mentions:
41 Fields:
Translation:
HumansCells
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Linker Histone H1.2 cooperates with Cul4A and PAF1 to drive H4K31 ubiquitylation-mediated transactivation. Cell Rep. 2013 Dec 26; 5(6):1690-703.
Kim K, Lee B, Kim J, Choi J, Kim JM, Xiong Y, Roeder RG, An W. PMID: 24360965; PMCID: PMC3901356.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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The histone variant MacroH2A regulates Ca(2+) influx through TRPC3 and TRPC6 channels. Oncogenesis. 2013 Oct 28; 2:e77.
Kim JM, Heo K, Choi J, Kim K, An W. PMID: 24165580; PMCID: PMC3816217.
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PubMed Mentions:
23
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VprBP has intrinsic kinase activity targeting histone H2A and represses gene transcription. Mol Cell. 2013 Nov 07; 52(3):459-67.
Kim K, Kim JM, Kim JS, Choi J, Lee YS, Neamati N, Song JS, Heo K, An W. PMID: 24140421; PMCID: PMC3851289.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Gene dysregulation by histone variant H2A.Z in bladder cancer. Epigenetics Chromatin. 2013 Oct 16; 6(1):34.
Kim K, Punj V, Choi J, Heo K, Kim JM, Laird PW, An W. PMID: 24279307; PMCID: PMC3853418.
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PubMed Mentions:
50 Fields:
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Nuclear CaMKII enhances histone H3 phosphorylation and remodels chromatin during cardiac hypertrophy. Nucleic Acids Res. 2013 09; 41(16):7656-72.
Awad S, Kunhi M, Little GH, Bai Y, An W, Bers D, Kedes L, Poizat C. PMID: 23804765; PMCID: PMC3763528.
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PubMed Mentions:
29 Fields:
Translation:
AnimalsCells
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Biological implications and regulatory mechanisms of long-range chromosomal interactions. J Biol Chem. 2013 Aug 02; 288(31):22369-77.
Wei Z, Huang D, Gao F, Chang WH, An W, Coetzee GA, Wang K, Lu W. PMID: 23779110; PMCID: PMC3829327.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Klf4 organizes long-range chromosomal interactions with the oct4 locus in reprogramming and pluripotency. Cell Stem Cell. 2013 Jul 03; 13(1):36-47.
Wei Z, Gao F, Kim S, Yang H, Lyu J, An W, Wang K, Lu W. PMID: 23747203.
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PubMed Mentions:
125 Fields:
Translation:
HumansAnimalsCells
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The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells. Sci Rep. 2013; 3:1588.
Gao F, Wei Z, An W, Wang K, Lu W. PMID: 23549118; PMCID: PMC4070749.
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PubMed Mentions:
15 Fields:
Translation:
HumansCells
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An essential role of variant histone H3.3 for ectomesenchyme potential of the cranial neural crest. PLoS Genet. 2012 Sep; 8(9):e1002938.
Cox SG, Kim H, Garnett AT, Medeiros DM, An W, Crump JG. PMID: 23028350; PMCID: PMC3447937.
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PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Cell-penetrating H4 tail peptides potentiate p53-mediated transactivation via inhibition of G9a and HDAC1. Oncogene. 2013 May 16; 32(20):2510-20.
Heo K, Kim JS, Kim K, Kim H, Choi J, Yang K, An W. PMID: 22751130.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Functional interplay between p53 acetylation and H1.2 phosphorylation in p53-regulated transcription. Oncogene. 2012 Sep 27; 31(39):4290-301.
Kim K, Jeong KW, Kim H, Choi J, Lu W, Stallcup MR, An W. PMID: 22249259; PMCID: PMC3330162.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansCells
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Vpr-binding protein antagonizes p53-mediated transcription via direct interaction with H3 tail. Mol Cell Biol. 2012 Feb; 32(4):783-96.
Kim K, Heo K, Choi J, Jackson S, Kim H, Xiong Y, An W. PMID: 22184063; PMCID: PMC3272969.
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PubMed Mentions:
26 Fields:
Translation:
HumansCells
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p53 requires an intact C-terminal domain for DNA binding and transactivation. J Mol Biol. 2012 Feb 03; 415(5):843-54.
Kim H, Kim K, Choi J, Heo K, Baek HJ, Roeder RG, An W. PMID: 22178617; PMCID: PMC3267882.
View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65.
Jeong KW, Kim K, Situ AJ, Ulmer TS, An W, Stallcup MR. PMID: 22081016; PMCID: PMC3230772.
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PubMed Mentions:
80 Fields:
Translation:
HumansCells
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Selective requirement of H2B N-Terminal tail for p14ARF-induced chromatin silencing. Nucleic Acids Res. 2011 Nov; 39(21):9167-80.
Choi J, Kim H, Kim K, Lee B, Lu W, An W. PMID: 21846774; PMCID: PMC3241654.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ. Nucleic Acids Res. 2011 Oct; 39(19):8329-41.
Kim H, Heo K, Choi J, Kim K, An W. PMID: 21742762; PMCID: PMC3201866.
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PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Res. 2011 Jan; 39(1):104-18.
Choi SH, Heo K, Byun HM, An W, Lu W, Yang AS. PMID: 20841325; PMCID: PMC3017615.
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PubMed Mentions:
35 Fields:
Translation:
HumansCells
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Cooperative action of TIP48 and TIP49 in H2A.Z exchange catalyzed by acetylation of nucleosomal H2A. Nucleic Acids Res. 2009 Oct; 37(18):5993-6007.
Choi J, Heo K, An W. PMID: 19696079; PMCID: PMC2764430.
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PubMed Mentions:
43 Fields:
Translation:
HumansCells
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Requirement of histone methyltransferase SMYD3 for estrogen receptor-mediated transcription. J Biol Chem. 2009 Jul 24; 284(30):19867-77.
Kim H, Heo K, Kim JH, Kim K, Choi J, An W. PMID: 19509295; PMCID: PMC2740412.
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PubMed Mentions:
49 Fields:
Translation:
HumansCells
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CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell. 2008 Aug 22; 31(4):510-519.
Kim JH, Yang CK, Heo K, Roeder RG, An W, Stallcup MR. PMID: 18722177; PMCID: PMC2562329.
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PubMed Mentions:
94 Fields:
Translation:
HumansAnimalsCells
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30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol. 2008 Sep 12; 381(4):816-25.
Robinson PJ, An W, Routh A, Martino F, Chapman L, Roeder RG, Rhodes D. PMID: 18653199; PMCID: PMC3870898.
View in:
PubMed Mentions:
154 Fields:
Translation:
AnimalsCells
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FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11; 30(1):86-97.
Heo K, Kim H, Choi SH, Choi J, Kim K, Gu J, Lieber MR, Yang AS, An W. PMID: 18406329.
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PubMed Mentions:
111 Fields:
Translation:
HumansAnimalsCells
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Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription. J Biol Chem. 2008 Apr 04; 283(14):9113-26.
Kim K, Choi J, Heo K, Kim H, Levens D, Kohno K, Johnson EM, Brock HW, An W. PMID: 18258596; PMCID: PMC2431041.
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PubMed Mentions:
67 Fields:
Translation:
HumansCells
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Purification and characterization of cellular proteins associated with histone H4 tails. J Biol Chem. 2007 Jul 20; 282(29):21024-31.
Choi J, Kim B, Heo K, Kim K, Kim H, Zhan Y, Ranish JA, An W. PMID: 17548343.
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PubMed Mentions:
6 Fields:
Translation:
HumansCells
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Isolation and characterization of proteins associated with histone H3 tails in vivo. J Biol Chem. 2007 May 25; 282(21):15476-83.
Heo K, Kim B, Kim K, Choi J, Kim H, Zhan Y, Ranish JA, An W. PMID: 17403666.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansCells
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Histone acetylation and methylation: combinatorial players for transcriptional regulation. Subcell Biochem. 2007; 41:351-69.
An W. PMID: 17484136.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol. 2006 Feb; 26(3):1156-64.
Doyen CM, An W, Angelov D, Bondarenko V, Mietton F, Studitsky VM, Hamiche A, Roeder RG, Bouvet P, Dimitrov S. PMID: 16428466; PMCID: PMC1347033.
View in:
PubMed Mentions:
72 Fields:
Translation:
AnimalsCells
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SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J. 2004 Oct 01; 23(19):3815-24.
Angelov D, Verdel A, An W, Bondarenko V, Hans F, Doyen CM, Studitsky VM, Hamiche A, Roeder RG, Bouvet P, Dimitrov S. PMID: 15372075; PMCID: PMC522799.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell. 2004 Jun 11; 117(6):735-48.
An W, Kim J, Roeder RG. PMID: 15186775.
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PubMed Mentions:
234 Fields:
Translation:
HumansAnimalsCells
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Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol. 2004 Apr; 11(4):308-15.
Thompson PR, Wang D, Wang L, Fulco M, Pediconi N, Zhang D, An W, Ge Q, Roeder RG, Wong J, Levrero M, Sartorelli V, Cotter RJ, Cole PA. PMID: 15004546.
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PubMed Mentions:
203 Fields:
Translation:
AnimalsCells
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Reconstitution and transcriptional analysis of chromatin in vitro. Methods Enzymol. 2004; 377:460-74.
An W, Roeder RG. PMID: 14979045.
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PubMed Mentions:
32 Fields:
Translation:
HumansAnimalsCells
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mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell. 2003 Aug; 12(2):475-87.
Wang H, An W, Cao R, Xia L, Erdjument-Bromage H, Chatton B, Tempst P, Roeder RG, Zhang Y. PMID: 14536086.
View in:
PubMed Mentions:
148 Fields:
Translation:
HumansAnimalsCells
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Direct association of p300 with unmodified H3 and H4 N termini modulates p300-dependent acetylation and transcription of nucleosomal templates. J Biol Chem. 2003 Jan 17; 278(3):1504-10.
An W, Roeder RG. PMID: 12421817.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. Mol Cell. 2002 Apr; 9(4):811-21.
An W, Palhan VB, Karymov MA, Leuba SH, Roeder RG. PMID: 11983172.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem. 2002 Feb 15; 277(7):5498-505.
Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG. PMID: 11734557.
View in:
PubMed Mentions:
45 Fields:
Translation:
HumansCells
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Activator-dependent transcription from chromatin in vitro involving targeted histone acetylation by p300. Mol Cell. 2000 Sep; 6(3):551-61.
Kundu TK, Palhan VB, Wang Z, An W, Cole PA, Roeder RG. PMID: 11030335.
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PubMed Mentions:
84 Fields:
Translation:
HumansCells
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The site of binding of linker histone to the nucleosome does not depend upon the amino termini of core histones. Biochimie. 1999 Jul; 81(7):727-32.
An W, Zlatanova J, Leuba SH, van Holde K. PMID: 10492019.
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PubMed Mentions: Fields:
Translation:
HumansCells
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The non-histone chromatin protein HMG1 protects linker DNA on the side opposite to that protected by linker histones. J Biol Chem. 1998 Oct 09; 273(41):26289-91.
An W, van Holde K, Zlatanova J. PMID: 9756855.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
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Linker histone protection of chromatosomes reconstituted on 5S rDNA from Xenopus borealis:a reinvestigation. Nucleic Acids Res. 1998 Sep 01; 26(17):4042-6.
An W, van Holde K, Zlatanova J. PMID: 9705517; PMCID: PMC147788.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Linker histone protects linker DNA on only one side of the core particle and in a sequence-dependent manner. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3396-401.
An W, Leuba SH, van Holde K, Zlatanova J. PMID: 9520377; PMCID: PMC19847.
View in:
PubMed Mentions:
27 Fields:
Translation:
AnimalsCells