Tobias S Ulmer, PhD

TitleAssociate Professor of Physiology and Neuroscience
InstitutionUniversity of Southern California
DepartmentZilkha Neurogenetic Institute
AddressZNI 111, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 4326
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    Collapse Overview 
    Collapse Overview
    Dr. Ulmer received his PhD from the University of Oxford after completing his undergraduate work at the University of Zurich. After completing postdoctoral work at NIH, Dr. Ulmer establishes his research group at the University of Southern California (USC).

    His research program centers on elucidating the molecular mechanism underlying physiological function and pathological dysfunction, respectively, of biological processes at atomic resolution. Specifically, the three-dimensional structure of proteins, their dynamics as well as protein-protein and protein-lipid interactions are determined. As a principal research tool, high-resolution, multidimensional solution-state nuclear magnetic resonance (NMR) spectroscopy is employed. His overarching interest is devoted to the structural biology of proteins that are either membrane embedded or membrane surface-bound.

    Specifically, his laboratory focuses on understanding
    (1) the structural basis of transmembrane signaling in cell surface receptors, and
    (2) the mechanism of carnitine palmitoyltransferase 1 regulation.

    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms of Integrin Receptor Transmembrane Signaling
    NIH/NHLBI R01HL089726Apr 15, 2008 - Mar 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kim J, Shin Y, Lee S, Kim M, Punj V, Lu JF, Shin H, Kim K, Ulmer T, Koh J, Jeong D, An W. Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3. Cell Rep. 2018 Jul 03; 24(1):224-237. PMID: 29972783.
      View in: PubMed
    2. Kim K, Shin Y, Kim J, Ulmer T, An W. H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis. Epigenetics Chromatin. 2018 May 28; 11(1):23. PMID: 29807539.
      View in: PubMed
    3. Situ AJ, Kang SM, Frey BB, An W, Kim C, Ulmer T. Membrane Anchoring of a-Helical Proteins: Role of Tryptophan. J Phys Chem B. 2018 01 25; 122(3):1185-1194. PMID: 29323921.
      View in: PubMed
    4. Schmidt T, Situ AJ, Ulmer T. Direct Evaluation of Protein-Lipid Contacts Reveals Protein Membrane Immersion and Isotropic Bicelle Structure. J Phys Chem Lett. 2016 Nov 03; 7(21):4420-4426. PMID: 27776216.
      View in: PubMed
    5. Schmidt T, Situ AJ, Ulmer T. Structural and thermodynamic basis of proline-induced transmembrane complex stabilization. Sci Rep. 2016 Jul 20; 6:29809. PMID: 27436065; PMCID: PMC4951694.
    6. Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer T. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 08 19; 291(34):17536-46. PMID: 27365391; PMCID: PMC5016151 [Available on 08/19/17].
    7. Kim K, Punj V, Kim JM, Lee S, Ulmer T, Lu W, Rice JC, An W. MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. PMID: 26744418; PMCID: PMC4719310.
    8. Kim JM, Kim K, Punj V, Liang G, Ulmer T, Lu W, An W. Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. PMID: 26581166; PMCID: PMC4652225.
    9. Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer T, An W. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. PMID: 26350217; PMCID: PMC4605318.
    10. Rinaldi C, Schmidt T, Situ AJ, Johnson JO, Lee PR, Chen KL, Bott LC, Fadó R, Harmison GH, Parodi S, Grunseich C, Renvoisé B, Biesecker LG, De Michele G, Santorelli FM, Filla A, Stevanin G, Dürr A, Brice A, Casals N, Traynor BJ, Blackstone C, Ulmer T, Fischbeck KH. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. 2015 May; 72(5):561-70. PMID: 25751282.
      View in: PubMed
    11. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg MH, Ulmer T. Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. PMID: 25632962; PMCID: PMC4375483.
    12. Situ AJ, Schmidt T, Mazumder P, Ulmer T. Characterization of membrane protein interactions by isothermal titration calorimetry. J Mol Biol. 2014 Oct 23; 426(21):3670-80. PMID: 25178257.
      View in: PubMed
    13. Samanta S, Situ AJ, Ulmer T. Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1. Biopolymers. 2014 Apr; 101(4):398-405. PMID: 24037959; PMCID: PMC3907070.
    14. Lokappa SB, Suk JE, Balasubramanian A, Samanta S, Situ AJ, Ulmer T. Sequence and membrane determinants of the random coil-helix transition of a-synuclein. J Mol Biol. 2014 May 15; 426(10):2130-44. PMID: 24607710.
      View in: PubMed
    15. Mazumder P, Suk JE, Ulmer T. Insight into a-synuclein plasticity and misfolding from differential micelle binding. J Phys Chem B. 2013 Oct 03; 117(39):11448-59. PMID: 23978162; PMCID: PMC3946565.
    16. Suk JE, Situ AJ, Ulmer T. Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics. J Am Chem Soc. 2012 Jun 06; 134(22):9030-3. PMID: 22626249; PMCID: PMC3415561.
    17. Sahu D, Zhao Z, Tsen F, Cheng CF, Park R, Situ AJ, Dai J, Eginli A, Shams S, Chen M, Ulmer T, Conti P, Woodley DT, Li W. A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors. Mol Biol Cell. 2012 Feb; 23(4):602-13. PMID: 22190738; PMCID: PMC3279389.
    18. Kim C, Schmidt T, Cho EG, Ye F, Ulmer T, Ginsberg MH. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2011 Dec 18; 481(7380):209-13. PMID: 22178926; PMCID: PMC3257387.
    19. Jeong KW, Kim K, Situ AJ, Ulmer T, An W, Stallcup MR. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. PMID: 22081016; PMCID: PMC3230772.
    20. Rao JN, Warren GZ, Estolt-Povedano S, Zammit VA, Ulmer T. An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. J Biol Chem. 2011 Dec 09; 286(49):42545-54. PMID: 21990363; PMCID: PMC3234983.
    21. Lokappa SB, Ulmer T. Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles. J Biol Chem. 2011 Jun 17; 286(24):21450-7. PMID: 21524999; PMCID: PMC3122204.
    22. Rao JN, Jao CC, Hegde BG, Langen R, Ulmer T. A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. J Am Chem Soc. 2010 Jun 30; 132(25):8657-68. PMID: 20524659; PMCID: PMC2903201.
    23. Ulmer T. Structural basis of transmembrane domain interactions in integrin signaling. Cell Adh Migr. 2010 Apr-Jun; 4(2):243-8. PMID: 20168080; PMCID: PMC2900621.
    24. Suk JE, Lokappa SB, Ulmer T. The clustering and spatial arrangement of beta-sheet sequence, but not order, govern alpha-synuclein fibrillogenesis. Biochemistry. 2010 Feb 23; 49(7):1533-40. PMID: 20121219; PMCID: PMC2841006.
    25. Rao JN, Kim YE, Park LS, Ulmer T. Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding. J Mol Biol. 2009 Jul 17; 390(3):516-29. PMID: 19481090; PMCID: PMC2731582.
    26. Lau TL, Kim C, Ginsberg MH, Ulmer T. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009 May 06; 28(9):1351-61. PMID: 19279667; PMCID: PMC2683045.
    27. Kim C, Lau TL, Ulmer T, Ginsberg MH. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood. 2009 May 07; 113(19):4747-53. PMID: 19218549; PMCID: PMC2680374.
    28. Lau TL, Dua V, Ulmer T. Structure of the integrin alphaIIb transmembrane segment. J Biol Chem. 2008 Jun 06; 283(23):16162-8. PMID: 18417472; PMCID: PMC3259656.
    29. Rao JN, Dua V, Ulmer T. Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules. Biochemistry. 2008 Apr 22; 47(16):4651-6. PMID: 18366183.
      View in: PubMed
    30. Lau TL, Partridge AW, Ginsberg MH, Ulmer T. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry. 2008 Apr 01; 47(13):4008-16. PMID: 18321071.
      View in: PubMed
    31. Mac TT, von Hacht A, Hung KC, Dutton RJ, Boyd D, Bardwell JC, Ulmer T. Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. J Biol Chem. 2008 Jan 11; 283(2):824-32. PMID: 18003611.
      View in: PubMed
    32. Hung KC, Mac TT, Ulmer T. NMR assignment of the periplasmic oxidoreductase DsbH from Chlamydia. Biomol NMR Assign. 2007 Dec; 1(2):195-6. PMID: 19636863.
      View in: PubMed
    33. Ulmer T, Bax A. Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J Biol Chem. 2005 Dec 30; 280(52):43179-87. PMID: 16166095.
      View in: PubMed
    34. Ulmer T, Bax A, Cole NB, Nussbaum RL. Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem. 2005 Mar 11; 280(10):9595-603. PMID: 15615727.
      View in: PubMed
    35. Jaroniec CP, Ulmer T, Bax A. Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins. J Biomol NMR. 2004 Oct; 30(2):181-94. PMID: 15666562.
      View in: PubMed
    36. Ulmer T, Campbell ID, Boyd J. Amide proton relaxation measurements employing a highly deuterated protein. J Magn Reson. 2004 Feb; 166(2):190-201. PMID: 14729031.
      View in: PubMed
    37. Ulmer T, Ramirez BE, Delaglio F, Bax A. Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy. J Am Chem Soc. 2003 Jul 30; 125(30):9179-91. PMID: 15369375.
      View in: PubMed
    38. Ulmer T, Calderwood DA, Ginsberg MH, Campbell ID. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003 Jul 15; 42(27):8307-12. PMID: 12846579.
      View in: PubMed
    39. Ulmer T, Soelaiman S, Li S, Klee CB, Tang WJ, Bax A. Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem. 2003 Aug 01; 278(31):29261-6. PMID: 12724328.
      View in: PubMed
    40. García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer T, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Structural determinants of integrin recognition by talin. Mol Cell. 2003 Jan; 11(1):49-58. PMID: 12535520.
      View in: PubMed
    41. Ulmer T, Campbell ID, Boyd J. The effects of dissolved oxygen upon amide proton relaxation and chemical shift in a perdeuterated protein. J Magn Reson. 2002 Aug; 157(2):181-9. PMID: 12323136.
      View in: PubMed
    42. Ulmer T, Werner JM, Campbell ID. SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn. Structure. 2002 Jul; 10(7):901-11. PMID: 12121645.
      View in: PubMed