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    Tobias S Ulmer, PhD

    TitleAssociate Professor of Physiology and Neuroscience
    SchoolKeck School of Medicine of USC
    DepartmentZilkha Neurogenetic Institute
    AddressZNI 111, 1501 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 4326
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      Collapse Overview 
      Collapse Overview
      Dr. Ulmer received his PhD from the University of Oxford after completing his undergraduate work at the University of Zurich. After completing postdoctoral work at NIH, Dr. Ulmer establishes his research group at the University of Southern California (USC).

      His research program centers on elucidating the molecular mechanism underlying physiological function and pathological dysfunction, respectively, of biological processes at atomic resolution. Specifically, the three-dimensional structure of proteins, their dynamics as well as protein-protein and protein-lipid interactions are determined. As a principal research tool, high-resolution, multidimensional solution-state nuclear magnetic resonance (NMR) spectroscopy is employed. His overarching interest is devoted to the structural biology of proteins that are either membrane embedded or membrane surface-bound.

      Specifically, his laboratory focuses on understanding
      (1) the structural basis of transmembrane signaling in cell surface receptors, and
      (2) the mechanism of carnitine palmitoyltransferase 1 regulation.

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zou M, Bhatia A, Dong H, Jayaprakash P, Guo J, Sahu D, Hou Y, Tsen F, Tong C, O'Brien K, Situ AJ, Schmidt T, Chen M, Ying Q, Ulmer T, Woodley DT, Li W. Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2017 Apr; 36(15):2160-2171. PMID: 27721406.
        View in: PubMed
      2. Schmidt T, Situ AJ, Ulmer T. Structural and thermodynamic basis of proline-induced transmembrane complex stabilization. Sci Rep. 2016 Jul 20; 6:29809. PMID: 27436065; PMCID: PMC4951694.
      3. Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer T. A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors. J Biol Chem. 2016 Aug 19; 291(34):17536-46. PMID: 27365391; PMCID: PMC5016151 [Available on 08/19/17].
      4. Kim K, Punj V, Kim JM, Lee S, Ulmer T, Lu W, Rice JC, An W. MMP-9 facilitates selective proteolysis of the histone H3 tail at genes necessary for proficient osteoclastogenesis. Genes Dev. 2016 Jan 15; 30(2):208-19. PMID: 26744418; PMCID: PMC4719310.
      5. Kim JM, Kim K, Punj V, Liang G, Ulmer T, Lu W, An W. Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3. Sci Rep. 2015 Nov 19; 5:16714. PMID: 26581166; PMCID: PMC4652225.
      6. Kim JM, Kim K, Schmidt T, Punj V, Tucker H, Rice JC, Ulmer T, An W. Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells. Nucleic Acids Res. 2015 Oct 15; 43(18):8868-83. PMID: 26350217; PMCID: PMC4605318.
      7. Rinaldi C, Schmidt T, Situ AJ, Johnson JO, Lee PR, Chen KL, Bott LC, Fadó R, Harmison GH, Parodi S, Grunseich C, Renvoisé B, Biesecker LG, De Michele G, Santorelli FM, Filla A, Stevanin G, Dürr A, Brice A, Casals N, Traynor BJ, Blackstone C, Ulmer T, Fischbeck KH. Mutation in CPT1C Associated With Pure Autosomal Dominant Spastic Paraplegia. JAMA Neurol. 2015 May; 72(5):561-70. PMID: 25751282.
        View in: PubMed
      8. Schmidt T, Suk JE, Ye F, Situ AJ, Mazumder P, Ginsberg MH, Ulmer T. Annular anionic lipids stabilize the integrin aIIbß3 transmembrane complex. J Biol Chem. 2015 Mar 27; 290(13):8283-93. PMID: 25632962; PMCID: PMC4375483.
      9. Situ AJ, Schmidt T, Mazumder P, Ulmer T. Characterization of membrane protein interactions by isothermal titration calorimetry. J Mol Biol. 2014 Oct 23; 426(21):3670-80. PMID: 25178257.
        View in: PubMed
      10. Samanta S, Situ AJ, Ulmer T. Structural characterization of the regulatory domain of brain carnitine palmitoyltransferase 1. Biopolymers. 2014 Apr; 101(4):398-405. PMID: 24037959; PMCID: PMC3907070.
      11. Lokappa SB, Suk JE, Balasubramanian A, Samanta S, Situ AJ, Ulmer T. Sequence and membrane determinants of the random coil-helix transition of a-synuclein. J Mol Biol. 2014 May 15; 426(10):2130-44. PMID: 24607710.
        View in: PubMed
      12. Mazumder P, Suk JE, Ulmer T. Insight into a-synuclein plasticity and misfolding from differential micelle binding. J Phys Chem B. 2013 Oct 03; 117(39):11448-59. PMID: 23978162; PMCID: PMC3946565.
      13. Suk JE, Situ AJ, Ulmer T. Construction of covalent membrane protein complexes and high-throughput selection of membrane mimics. J Am Chem Soc. 2012 Jun 06; 134(22):9030-3. PMID: 22626249; PMCID: PMC3415561.
      14. Sahu D, Zhao Z, Tsen F, Cheng CF, Park R, Situ AJ, Dai J, Eginli A, Shams S, Chen M, Ulmer T, Conti P, Woodley DT, Li W. A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors. Mol Biol Cell. 2012 Feb; 23(4):602-13. PMID: 22190738; PMCID: PMC3279389.
      15. Kim C, Schmidt T, Cho EG, Ye F, Ulmer T, Ginsberg MH. Basic amino-acid side chains regulate transmembrane integrin signalling. Nature. 2011 Dec 18; 481(7380):209-13. PMID: 22178926; PMCID: PMC3257387.
      16. Jeong KW, Kim K, Situ AJ, Ulmer T, An W, Stallcup MR. Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation. Nat Struct Mol Biol. 2011 Nov 13; 18(12):1358-65. PMID: 22081016; PMCID: PMC3230772.
      17. Rao JN, Warren GZ, Estolt-Povedano S, Zammit VA, Ulmer T. An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. J Biol Chem. 2011 Dec 09; 286(49):42545-54. PMID: 21990363; PMCID: PMC3234983.
      18. Lokappa SB, Ulmer T. Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles. J Biol Chem. 2011 Jun 17; 286(24):21450-7. PMID: 21524999; PMCID: PMC3122204.
      19. Rao JN, Jao CC, Hegde BG, Langen R, Ulmer T. A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. J Am Chem Soc. 2010 Jun 30; 132(25):8657-68. PMID: 20524659; PMCID: PMC2903201.
      20. Ulmer T. Structural basis of transmembrane domain interactions in integrin signaling. Cell Adh Migr. 2010 Apr-Jun; 4(2):243-8. PMID: 20168080; PMCID: PMC2900621.
      21. Suk JE, Lokappa SB, Ulmer T. The clustering and spatial arrangement of beta-sheet sequence, but not order, govern alpha-synuclein fibrillogenesis. Biochemistry. 2010 Feb 23; 49(7):1533-40. PMID: 20121219; PMCID: PMC2841006.
      22. Rao JN, Kim YE, Park LS, Ulmer T. Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding. J Mol Biol. 2009 Jul 17; 390(3):516-29. PMID: 19481090; PMCID: PMC2731582.
      23. Lau TL, Kim C, Ginsberg MH, Ulmer T. The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J. 2009 May 06; 28(9):1351-61. PMID: 19279667; PMCID: PMC2683045.
      24. Kim C, Lau TL, Ulmer T, Ginsberg MH. Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood. 2009 May 07; 113(19):4747-53. PMID: 19218549; PMCID: PMC2680374.
      25. Lau TL, Dua V, Ulmer T. Structure of the integrin alphaIIb transmembrane segment. J Biol Chem. 2008 Jun 06; 283(23):16162-8. PMID: 18417472; PMCID: PMC3259656.
      26. Rao JN, Dua V, Ulmer T. Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules. Biochemistry. 2008 Apr 22; 47(16):4651-6. PMID: 18366183.
        View in: PubMed
      27. Lau TL, Partridge AW, Ginsberg MH, Ulmer T. Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry. 2008 Apr 01; 47(13):4008-16. PMID: 18321071.
        View in: PubMed
      28. Mac TT, von Hacht A, Hung KC, Dutton RJ, Boyd D, Bardwell JC, Ulmer T. Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. J Biol Chem. 2008 Jan 11; 283(2):824-32. PMID: 18003611.
        View in: PubMed
      29. Hung KC, Mac TT, Ulmer T. NMR assignment of the periplasmic oxidoreductase DsbH from Chlamydia. Biomol NMR Assign. 2007 Dec; 1(2):195-6. PMID: 19636863.
        View in: PubMed
      30. Ulmer T, Bax A. Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J Biol Chem. 2005 Dec 30; 280(52):43179-87. PMID: 16166095.
        View in: PubMed
      31. Ulmer T, Bax A, Cole NB, Nussbaum RL. Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem. 2005 Mar 11; 280(10):9595-603. PMID: 15615727.
        View in: PubMed
      32. Jaroniec CP, Ulmer T, Bax A. Quantitative J correlation methods for the accurate measurement of 13C'-13Calpha dipolar couplings in proteins. J Biomol NMR. 2004 Oct; 30(2):181-94. PMID: 15666562.
        View in: PubMed
      33. Ulmer T, Campbell ID, Boyd J. Amide proton relaxation measurements employing a highly deuterated protein. J Magn Reson. 2004 Feb; 166(2):190-201. PMID: 14729031.
        View in: PubMed
      34. Ulmer T, Ramirez BE, Delaglio F, Bax A. Evaluation of backbone proton positions and dynamics in a small protein by liquid crystal NMR spectroscopy. J Am Chem Soc. 2003 Jul 30; 125(30):9179-91. PMID: 15369375.
        View in: PubMed
      35. Ulmer T, Calderwood DA, Ginsberg MH, Campbell ID. Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry. 2003 Jul 15; 42(27):8307-12. PMID: 12846579.
        View in: PubMed
      36. Ulmer T, Soelaiman S, Li S, Klee CB, Tang WJ, Bax A. Calcium dependence of the interaction between calmodulin and anthrax edema factor. J Biol Chem. 2003 Aug 01; 278(31):29261-6. PMID: 12724328.
        View in: PubMed
      37. García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer T, Critchley D, Campbell ID, Ginsberg MH, Liddington RC. Structural determinants of integrin recognition by talin. Mol Cell. 2003 Jan; 11(1):49-58. PMID: 12535520.
        View in: PubMed
      38. Ulmer T, Campbell ID, Boyd J. The effects of dissolved oxygen upon amide proton relaxation and chemical shift in a perdeuterated protein. J Magn Reson. 2002 Aug; 157(2):181-9. PMID: 12323136.
        View in: PubMed
      39. Ulmer T, Werner JM, Campbell ID. SH3-SH2 domain orientation in Src kinases: NMR studies of Fyn. Structure. 2002 Jul; 10(7):901-11. PMID: 12121645.
        View in: PubMed
      40. Ulmer T, Yaspan B, Ginsberg MH, Campbell ID. NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution. Biochemistry. 2001 Jun 26; 40(25):7498-508. PMID: 11412103.
        View in: PubMed
      41. Ginsberg MH, Yaspan B, Forsyth J, Ulmer T, Campbell ID, Slepak M. A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation. J Biol Chem. 2001 Jun 22; 276(25):22514-21. PMID: 11304543.
        View in: PubMed
      42. Arold ST, Ulmer T, Mulhern TD, Werner JM, Ladbury JE, Campbell ID, Noble ME. The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases. J Biol Chem. 2001 May 18; 276(20):17199-205. PMID: 11278857.
        View in: PubMed