Wei Li, PhD
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Title(s) | Professor of Dermatology |
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Address | NOR 5301 1441 Eastlake Avenue Health Sciences Campus Los Angeles CA 90089-9176
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Phone | +1 323 865 0618 |
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vCard | Download vCard |
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Title(s) | Director, MSS Graduate Program |
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Biography Xinjiang University, Urumqi, China | B.S. | 1982 | General Biology | CUSBEA, Guangzhou, China | English Certificate | 1984 | English | Albert Einstein College of Medicine, New York City, NY | Ph.D. | 1991 | Biochemistry and Molecular Biology | New York University Medical Center, New York City, NY | Postdoctoral Research | 1993 | Signal Transduction | University of Chicago, Chicago, IL | Assistant Professor | 1993-99 | Cancer Biology | University of Southern California, Los Angeles | Professor | 1999- | Wound Healing and Tumor Biology |
Overview Dr. Li research focuses on the following topics: 1) Identification of the "driver genes" for wound healing, 2) Identification of tumor-secreted molecules as drug targets for TNBCs (triple negative breast cancers). 3) Signal transduction to understand the cell motility signaling, which initiates at the cell surface, propagates via cytosolic signaling networks and executes by newly expressed and secreted gene products.
His experimental model systems are less manipulated primary human skin cells, whose migration is essential for both physiological processes, such as skin wound healing, and pathological occurrence, such as skin cancer, PDX models for TNBCs and pig models for wound healing.
Research ORNG Applications Bibliographic
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(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression. Oncogene. 2017 04; 36(15):2160-2171.
PMID: 27721406.
View in: PubMed Mentions: 12 Fields: Translation: HumansCells
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Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure. Adv Wound Care (New Rochelle). 2016 Apr 01; 5(4):176-184.
PMID: 27076995.
View in: PubMed Mentions:
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Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605.
PMID: 26846992.
View in: PubMed Mentions: 13 Fields: Translation: HumansCells
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Hsp90a and Hsp90ß together operate a hypoxia and nutrient paucity stress-response mechanism during wound healing. J Cell Sci. 2015 Apr 15; 128(8):1475-80.
PMID: 25736295.
View in: PubMed Mentions: 14 Fields: Translation: HumansAnimalsCells
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Identification of the critical therapeutic entity in secreted Hsp90a that promotes wound healing in newly re-standardized healthy and diabetic pig models. PLoS One. 2014; 9(12):e113956.
PMID: 25464502.
View in: PubMed Mentions: 7 Fields: Translation: Animals
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Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59.
PMID: 24126057.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally. Int Rev Cell Mol Biol. 2013; 303:203-35.
PMID: 23445811.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
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The anti-motility signaling mechanism of TGFß3 that controls cell traffic during skin wound healing. Biol Open. 2012 Dec 15; 1(12):1169-77.
PMID: 23259050.
View in: PubMed Mentions:
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A potentially common peptide target in secreted heat shock protein-90a for hypoxia-inducible factor-1a-positive tumors. Mol Biol Cell. 2012 Feb; 23(4):602-13.
PMID: 22190738.
View in: PubMed Mentions: 24 Fields: Translation: HumansAnimalsCells
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A fragment of secreted Hsp90a carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice. J Clin Invest. 2011 Nov; 121(11):4348-61.
PMID: 22019588.
View in: PubMed Mentions: 34 Fields: Translation: HumansAnimalsCells
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Secreted heat shock protein-90 (Hsp90) in wound healing and cancer. Biochim Biophys Acta. 2012 Mar; 1823(3):730-41.
PMID: 21982864.
View in: PubMed Mentions: 47 Fields: Translation: HumansAnimalsCells
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TbetaRI/Alk5-independent TbetaRII signaling to ERK1/2 in human skin cells according to distinct levels of TbetaRII expression. J Cell Sci. 2011 Jan 01; 124(Pt 1):19-24.
Bandyopadhyay B, Han A, Dai J, Fan J, Li Y, Chen M, Woodley DT, Li W. PMID: 21172820.
View in: PubMed Mentions: 15 Fields: Translation: HumansCells
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Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90alpha autocrine signaling to promote keratinocyte migration. J Cell Sci. 2009 May 15; 122(Pt 10):1495-8.
Woodley DT, Fan J, Cheng CF, Li Y, Chen M, Bu G, Li W. PMID: 19383717.
View in: PubMed Mentions: 24 Fields: Translation: HumansCells
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Characterization of molecular mechanisms underlying mutations in dystrophic epidermolysis bullosa using site-directed mutagenesis. J Biol Chem. 2008 Jun 27; 283(26):17838-45.
Woodley DT, Hou Y, Martin S, Li W, Chen M. PMID: 18450758.
View in: PubMed Mentions: 10 Fields: Translation: HumansCells
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Transforming growth factor alpha (TGFalpha)-stimulated secretion of HSP90alpha: using the receptor LRP-1/CD91 to promote human skin cell migration against a TGFbeta-rich environment during wound healing. Mol Cell Biol. 2008 May; 28(10):3344-58.
Cheng CF, Fan J, Fedesco M, Guan S, Li Y, Bandyopadhyay B, Bright AM, Yerushalmi D, Liang M, Chen M, Han YP, Woodley DT, Li W. PMID: 18332123.
View in: PubMed Mentions: 81 Fields: Translation: HumansCells
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Extracellular heat shock protein-90alpha: linking hypoxia to skin cell motility and wound healing. EMBO J. 2007 Mar 07; 26(5):1221-33.
Li W, Li Y, Guan S, Fan J, Cheng CF, Bright AM, Chinn C, Chen M, Woodley DT. PMID: 17304217.
View in: PubMed Mentions: 105 Fields: Translation: HumansAnimalsCells
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Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing. Mol Ther. 2007 Mar; 15(3):628-35.
Woodley DT, Remington J, Huang Y, Hou Y, Li W, Keene DR, Chen M. PMID: 17245357.
View in: PubMed Mentions: 33 Fields: Translation: HumansAnimalsCells
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A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol. 2006 Mar 27; 172(7):1093-105.
Bandyopadhyay B, Fan J, Guan S, Li Y, Chen M, Woodley DT, Li W. PMID: 16549496.
View in: PubMed Mentions: 49 Fields: Translation: HumansCells
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Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med. 2004 Jul; 10(7):693-5.
Woodley DT, Keene DR, Atha T, Huang Y, Lipman K, Li W, Chen M. PMID: 15195089.
View in: PubMed Mentions: 37 Fields: Translation: HumansAnimals
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Year | Publications |
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2004 | 1 | 2006 | 1 | 2007 | 2 | 2008 | 2 | 2009 | 1 | 2011 | 4 | 2012 | 1 | 2013 | 2 | 2014 | 1 | 2015 | 1 | 2016 | 3 |
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