Qilong Ying, PhD

Title(s)Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of USC
Phone+1 323 442 3308
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    Collapse Biography 
    Collapse Awards and Honors
    International Society for Stem Cell Research2016McEwen Award for Innovation
    University of Southern California2011Phi Kappa Phi Faculty Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Embryonic stem cell self-renewal
    NIH/NIGMS R01GM129305Aug 1, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Ground state rabbit pluripotent stem cells
    NIH R41OD023245Sep 15, 2017 - Sep 14, 2018
    Role: Principal Investigator
    Generation of Cre/lox rats
    NIH R24OD024626Aug 15, 2017 - Apr 30, 2021
    Role: Principal Investigator
    NIH R01OD010926Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator
    NIH/NCRR R01RR025881Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Chen X, Wang R, Liu X, Wu Y, Zhou T, Yang Y, Perez A, Chen YC, Hu L, Chadarevian JP, Assadieskandar A, Zhang C, Ying QL. A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3a and GSK3ß in Regulating Embryonic Stem Cell Fate. Dev Cell. 2017 12 04; 43(5):563-576.e4. PMID: 29207259.
      View in: PubMed
    2. Zhou X, Chadarevian JP, Ruiz B, Ying QL. Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency. Stem Cell Reports. 2017 09 12; 9(3):732-741. PMID: 28844657.
      View in: PubMed
    3. Ying QL, Smith A. The Art of Capturing Pluripotency: Creating the Right Culture. Stem Cell Reports. 2017 06 06; 8(6):1457-1464. PMID: 28591647.
      View in: PubMed
    4. Hong M, Jung E, Yang S, Jung W, Seong YJ, Park E, Bramos A, Kim KE, Lee S, Daghlian G, Seo JI, Choi I, Choi IS, Koh CJ, Kobielak A, Ying QL, Johnson M, Gardner D, Wong AK, Choi D, Hong YK. Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126. PMID: 27280889; PMCID: PMC4900649.
    5. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, Ying Q, Chen M, Woodley DT, Li W. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90a) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605. PMID: 26846992; PMCID: PMC4742873.
    6. Chen X, Ye S, Ying QL. Stem cell maintenance by manipulating signaling pathways: past, current and future. BMB Rep. 2015 Dec; 48(12):668-76. PMID: 26497581; PMCID: PMC4791322.
    7. Ye S, Zhang D, Cheng F, Wilson D, Mackay J, He K, Ban Q, Lv F, Huang S, Liu D, Ying QL. Wnt/ß-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016 Jan 15; 129(2):269-76. PMID: 26598557.
      View in: PubMed
    8. Qiu D, Ye S, Ruiz B, Zhou X, Liu D, Zhang Q, Ying QL. Klf2 and Tfcp2l1, Two Wnt/ß-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem Cell Reports. 2015 Sep 08; 5(3):314-22. PMID: 26321140; PMCID: PMC4618593.
    9. Zhou X, Contreras-Trujillo H, Ying QL. New insights into the conserved mechanism of pluripotency maintenance. Curr Opin Genet Dev. 2015 Oct; 34:1-9. PMID: 26183186.
      View in: PubMed
    10. He K, Lv W, Zheng D, Cheng F, Zhou T, Ye S, Ban Q, Ying Q, Huang B, Chen L, Wu G, Liu D. The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis. Oncotarget. 2015 Apr 20; 6(11):8687-97. PMID: 25826086; PMCID: PMC4496176.
    11. Kim H, Kim S, Song Y, Kim W, Ying QL, Jho EH. Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015; 2015:459301. PMID: 25945099; PMCID: PMC4402205.
    12. Hui J, Zhang J, Kim H, Tong C, Ying Q, Li Z, Mao X, Shi G, Yan J, Zhang Z, Xi G. Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3ß/ß-catenin signaling. Int J Neuropsychopharmacol. 2014 Dec 07; 18(5). PMID: 25522429; PMCID: PMC4376550.
    13. Tai CI, Schulze EN, Ying QL. Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner. Biol Open. 2014 Sep 19; 3(10):958-65. PMID: 25238758; PMCID: PMC4197444.
    14. Ye S, Liu D, Ying QL. Signaling pathways in induced naïve pluripotency. Curr Opin Genet Dev. 2014 Oct; 28:10-5. PMID: 25173148; PMCID: PMC4262619.
    15. Huang G, Yan H, Ye S, Tong C, Ying QL. STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates. Stem Cells. 2014 May; 32(5):1149-60. PMID: 24302476; PMCID: PMC4181708.
    16. Xi G, Hu P, Qu C, Qiu S, Tong C, Ying QL. Induced neural stem cells generated from rat fibroblasts. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):312-9. PMID: 24076032; PMCID: PMC3908478.
    17. Ye S, Li P, Tong C, Ying QL. Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J. 2013 Oct 02; 32(19):2548-60. PMID: 23942238; PMCID: PMC3791365.
    18. Yan HX, Wu HP, Zhang HL, Ashton C, Tong C, Wu H, Qian QJ, Wang HY, Ying QL. p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release. J Hepatol. 2013 Oct; 59(4):762-8. PMID: 23714159; PMCID: PMC3805120.
    19. Tai CI, Ying QL. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. J Cell Sci. 2013 Mar 01; 126(Pt 5):1093-8. PMID: 23345404.
      View in: PubMed
    20. Kim H, Wu J, Ye S, Tai CI, Zhou X, Yan H, Li P, Pera M, Ying QL. Modulation of ß-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun. 2013; 4:2403. PMID: 23985566; PMCID: PMC4183150.
    21. Yan HX, Wu HP, Ashton C, Tong C, Ying QL. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis. 2012 Oct; 33(10):2001-5. PMID: 22791818; PMCID: PMC3499043.
    22. Tong C, Huang G, Ashton C, Wu H, Yan H, Ying QL. Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs. J Genet Genomics. 2012 Jun 20; 39(6):275-80. PMID: 22749015; PMCID: PMC3856761.
    23. Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012; 7(4):e35892. PMID: 22540008; PMCID: PMC3335080.
    24. Huang G, Ashton C, Kumbhani DS, Ying QL. Genetic manipulations in the rat: progress and prospects. Curr Opin Nephrol Hypertens. 2011 Jul; 20(4):391-9. PMID: 21546835; PMCID: PMC3857098.
    25. Tong C, Huang G, Ashton C, Li P, Ying QL. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat Protoc. 2011 Jun; 6(6):827-44. PMID: 21637202; PMCID: PMC3855261.
    26. Wang ZQ, Chen K, Ying QL, Li P, Shih JC. Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. J Neural Transm (Vienna). 2011 Jul; 118(7):997-1001. PMID: 21607742; PMCID: PMC3435112.
    27. Huang G, Tong C, Kumbhani DS, Ashton C, Yan H, Ying QL. Beyond knockout rats: new insights into finer genome manipulation in rats. Cell Cycle. 2011 Apr 01; 10(7):1059-66. PMID: 21383544; PMCID: PMC3100883.
    28. Tong C, Li P, Wu NL, Yan Y, Ying QL. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature. 2010 Sep 09; 467(7312):211-3. PMID: 20703227; PMCID: PMC2937076.
    29. Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, Pera MF, Ying QL. Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310. PMID: 19109898; PMCID: PMC2735113.
    30. Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith A. The ground state of embryonic stem cell self-renewal. Nature. 2008 May 22; 453(7194):519-23. PMID: 18497825.
      View in: PubMed