Qilong Ying, PhD

Title(s)Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of Usc
AddressBCC 512 1425 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 3308
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    Collapse Biography 
    Collapse Awards and Honors
    International Society for Stem Cell Research2016McEwen Award for Innovation
    University of Southern California2011Phi Kappa Phi Faculty Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Embryonic stem cell self-renewal
    NIH R01GM129305Aug 1, 2018 - Apr 30, 2022
    Role: Principal Investigator
    Ground state rabbit pluripotent stem cells
    NIH R41OD023245Sep 15, 2017 - Jan 14, 2019
    Role: Principal Investigator
    Generation of Cre/lox rats
    NIH R24OD024626Aug 15, 2017 - Apr 30, 2021
    Role: Principal Investigator
    DERIVATION, PROPAGATION AND GENETIC MODIFICATION OF RAT EMBRYONIC STEM CELLS
    NIH R01OD010926Jan 1, 2010 - Dec 31, 2015
    Role: Principal Investigator
    DERIVATION, PROPAGATION AND GENETIC MODIFICATION OF RAT EMBRYONIC STEM CELLS
    NIH R01RR025881Jan 1, 2010 - Dec 31, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Relationship of PSC to embryos: Extending and refining capture of PSC lines from mammalian embryos. Bioessays. 2024 Oct 14; e2400077. Ying QL, Nichols J. PMID: 39400400.
      View in: PubMed   Mentions:    Fields:    
    2. A novel chemical genetic approach reveals paralog-specific role of ERK1/2 in mouse embryonic stem cell fate control. Front Cell Dev Biol. 2024; 12:1415621. Hu L, Xiao X, Huang W, Zhou T, Chen W, Zhang C, Ying QL. PMID: 39071800; PMCID: PMC11272557.
      View in: PubMed   Mentions:
    3. Kcnh2 deletion is associated with rat embryonic development defects via destruction of KCNH2‑integrin β1 complex. Int J Mol Med. 2024 02; 53(2). Hu S, Li Z, Liu H, Cao W, Meng Y, Liu C, He S, Lin Q, Shang M, Lin F, Yi N, Wang H, Sachinidis A, Ying Q, Li L, Peng L. PMID: 38063256; PMCID: PMC10760793.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25. Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z. PMID: 37293038; PMCID: PMC10245960.
      View in: PubMed   Mentions:
    5. An optimized proliferation system of embryonic stem cells for generating the rat model with large fragment modification. Biochem Biophys Res Commun. 2021 09 24; 571:8-13. Liu C, Cui Z, Yan Y, Wu NL, Li L, Ying Q, Peng L. PMID: 34298338.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. ERG1 plays an essential role in rat cardiomyocyte fate decision by mediating AKT signaling. Stem Cells. 2021 04; 39(4):443-457. Wang D, Liu C, Liu H, Meng Y, Lin F, Gu Y, Wang H, Shang M, Tong C, Sachinidis A, Ying Q, Li L, Peng L. PMID: 33426760.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway. J Cell Mol Med. 2019 05; 23(5):3629-3640. Wang D, Wang Y, Liu H, Tong C, Ying Q, Sachinidis A, Li L, Peng L. PMID: 30907509; PMCID: PMC6484303.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    8. A Chemical-Genetic Approach Reveals the Distinct Roles of GSK3α and GSK3β in Regulating Embryonic Stem Cell Fate. Dev Cell. 2017 12 04; 43(5):563-576.e4. Chen X, Wang R, Liu X, Wu Y, Zhou T, Yang Y, Perez A, Chen YC, Hu L, Chadarevian JP, Assadieskandar A, Zhang C, Ying QL. PMID: 29207259; PMCID: PMC5851779.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    9. Cytoplasmic and Nuclear TAZ Exert Distinct Functions in Regulating Primed Pluripotency. Stem Cell Reports. 2017 09 12; 9(3):732-741. Zhou X, Chadarevian JP, Ruiz B, Ying QL. PMID: 28844657; PMCID: PMC5599246.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    10. The Art of Capturing Pluripotency: Creating the Right Culture. Stem Cell Reports. 2017 06 06; 8(6):1457-1464. Ying QL, Smith A. PMID: 28591647; PMCID: PMC5470336.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    11. Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells. PLoS One. 2016; 11(6):e0157126. Hong M, Jung E, Yang S, Jung W, Seong YJ, Park E, Bramos A, Kim KE, Lee S, Daghlian G, Seo JI, Choi I, Choi IS, Koh CJ, Kobielak A, Ying QL, Johnson M, Gardner D, Wong AK, Choi D, Hong YK. PMID: 27280889; PMCID: PMC4900649.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    12. Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment. Sci Rep. 2016 Feb 05; 6:20605. Dong H, Zou M, Bhatia A, Jayaprakash P, Hofman F, Ying Q, Chen M, Woodley DT, Li W. PMID: 26846992; PMCID: PMC4742873.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    13. Stem cell maintenance by manipulating signaling pathways: past, current and future. BMB Rep. 2015 Dec; 48(12):668-76. Chen X, Ye S, Ying QL. PMID: 26497581; PMCID: PMC4791322.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    14. Wnt/β-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci. 2016 Jan 15; 129(2):269-76. Ye S, Zhang D, Cheng F, Wilson D, Mackay J, He K, Ban Q, Lv F, Huang S, Liu D, Ying QL. PMID: 26598557; PMCID: PMC4732286.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    15. Klf2 and Tfcp2l1, Two Wnt/β-Catenin Targets, Act Synergistically to Induce and Maintain Naive Pluripotency. Stem Cell Reports. 2015 Sep 08; 5(3):314-22. Qiu D, Ye S, Ruiz B, Zhou X, Liu D, Zhang Q, Ying QL. PMID: 26321140; PMCID: PMC4618593.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    16. New insights into the conserved mechanism of pluripotency maintenance. Curr Opin Genet Dev. 2015 Oct; 34:1-9. Zhou X, Contreras-Trujillo H, Ying QL. PMID: 26183186.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    17. The stromal genome heterogeneity between breast and prostate tumors revealed by a comparative transcriptomic analysis. Oncotarget. 2015 Apr 20; 6(11):8687-97. He K, Lv W, Zheng D, Cheng F, Zhou T, Ye S, Ban Q, Ying Q, Huang B, Chen L, Wu G, Liu D. PMID: 25826086; PMCID: PMC4496176.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    18. Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells. Stem Cells Int. 2015; 2015:459301. Kim H, Kim S, Song Y, Kim W, Ying QL, Jho EH. PMID: 25945099; PMCID: PMC4402205.
      View in: PubMed   Mentions: 6  
    19. Fluoxetine regulates neurogenesis in vitro through modulation of GSK-3β/β-catenin signaling. Int J Neuropsychopharmacol. 2014 Dec 07; 18(5). Hui J, Zhang J, Kim H, Tong C, Ying Q, Li Z, Mao X, Shi G, Yan J, Zhang Z, Xi G. PMID: 25522429; PMCID: PMC4376550.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    20. Stat3 signaling regulates embryonic stem cell fate in a dose-dependent manner. Biol Open. 2014 Sep 19; 3(10):958-65. Tai CI, Schulze EN, Ying QL. PMID: 25238758; PMCID: PMC4197444.
      View in: PubMed   Mentions: 10     Fields:    
    21. Signaling pathways in induced naïve pluripotency. Curr Opin Genet Dev. 2014 Oct; 28:10-5. Ye S, Liu D, Ying QL. PMID: 25173148; PMCID: PMC4262619.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    22. STAT3 phosphorylation at tyrosine 705 and serine 727 differentially regulates mouse ESC fates. Stem Cells. 2014 May; 32(5):1149-60. Huang G, Yan H, Ye S, Tong C, Ying QL. PMID: 24302476; PMCID: PMC4181708.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    23. Induced neural stem cells generated from rat fibroblasts. Genomics Proteomics Bioinformatics. 2013 Oct; 11(5):312-9. Xi G, Hu P, Qu C, Qiu S, Tong C, Ying QL. PMID: 24076032; PMCID: PMC3908478.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    24. Embryonic stem cell self-renewal pathways converge on the transcription factor Tfcp2l1. EMBO J. 2013 Oct 02; 32(19):2548-60. Ye S, Li P, Tong C, Ying QL. PMID: 23942238; PMCID: PMC3791365.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    25. p53 promotes inflammation-associated hepatocarcinogenesis by inducing HMGB1 release. J Hepatol. 2013 Oct; 59(4):762-8. Yan HX, Wu HP, Zhang HL, Ashton C, Tong C, Wu H, Qian QJ, Wang HY, Ying QL. PMID: 23714159; PMCID: PMC3805120.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    26. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. J Cell Sci. 2013 Mar 01; 126(Pt 5):1093-8. Tai CI, Ying QL. PMID: 23345404.
      View in: PubMed   Mentions: 60     Fields:    Translation:AnimalsCells
    27. Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal. Nat Commun. 2013; 4:2403. Kim H, Wu J, Ye S, Tai CI, Zhou X, Yan H, Li P, Pera M, Ying QL. PMID: 23985566; PMCID: PMC4183150.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    28. DNA damage-induced sustained p53 activation contributes to inflammation-associated hepatocarcinogenesis in rats. Oncogene. 2013 Sep 19; 32(38):4565-71. Yan HX, Wu HP, Zhang HL, Ashton C, Tong C, Wu J, Qian QJ, Wang HY, Ying QL. PMID: 23069657; PMCID: PMC3855850.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    29. Rats deficient for p53 are susceptible to spontaneous and carcinogen-induced tumorigenesis. Carcinogenesis. 2012 Oct; 33(10):2001-5. Yan HX, Wu HP, Ashton C, Tong C, Ying QL. PMID: 22791818; PMCID: PMC3499043.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    30. Rapid and cost-effective gene targeting in rat embryonic stem cells by TALENs. J Genet Genomics. 2012 Jun 20; 39(6):275-80. Tong C, Huang G, Ashton C, Wu H, Yan H, Ying QL. PMID: 22749015; PMCID: PMC3856761.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    31. Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. PLoS One. 2012; 7(4):e35892. Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P. PMID: 22540008; PMCID: PMC3335080.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    32. Genetic manipulations in the rat: progress and prospects. Curr Opin Nephrol Hypertens. 2011 Jul; 20(4):391-9. Huang G, Ashton C, Kumbhani DS, Ying QL. PMID: 21546835; PMCID: PMC3857098.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    33. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nat Protoc. 2011 Jun; 6(6):827-44. Tong C, Huang G, Ashton C, Li P, Ying QL. PMID: 21637202; PMCID: PMC3855261.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    34. Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. J Neural Transm (Vienna). 2011 Jul; 118(7):997-1001. Wang ZQ, Chen K, Ying QL, Li P, Shih JC. PMID: 21607742; PMCID: PMC3435112.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    35. Beyond knockout rats: new insights into finer genome manipulation in rats. Cell Cycle. 2011 Apr 01; 10(7):1059-66. Huang G, Tong C, Kumbhani DS, Ashton C, Yan H, Ying QL. PMID: 21383544; PMCID: PMC3100883.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    36. Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature. 2010 Sep 09; 467(7312):211-3. Tong C, Li P, Wu NL, Yan Y, Ying QL. PMID: 20703227; PMCID: PMC2937076.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    37. Germline competent embryonic stem cells derived from rat blastocysts. Cell. 2008 Dec 26; 135(7):1299-310. Li P, Tong C, Mehrian-Shai R, Jia L, Wu N, Yan Y, Maxson RE, Schulze EN, Song H, Hsieh CL, Pera MF, Ying QL. PMID: 19109898; PMCID: PMC2735113.
      View in: PubMed   Mentions: 275     Fields:    Translation:AnimalsCells
    38. The ground state of embryonic stem cell self-renewal. Nature. 2008 May 22; 453(7194):519-23. Ying QL, Wray J, Nichols J, Batlle-Morera L, Doble B, Woodgett J, Cohen P, Smith A. PMID: 18497825; PMCID: PMC5328678.
      View in: PubMed   Mentions: 1641     Fields:    Translation:AnimalsCells
    39. [Isolation and purification of human neutrophil elastase]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1986 Oct; 8(5):376-81. Zhang XH, Ying QL, Yan YZ. PMID: 2952311.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    40. Geographical variability of alpha-1-antitrypsin alleles in China: a study on six Chinese populations. Hum Genet. 1985; 69(2):184-7. Ying QL, Zhang ML, Liang CC, Liu XP, Huang YW, Wang RX, Zhang NJ, Chen LC, Chen LF, Yu NC, et al. PMID: 3871725.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    41. Alpha-1-antitrypsin types in five Chinese national minorities. Hum Genet. 1985; 71(3):225-6. Ying QL, Zhang ML, Liang CC, Chen LC, Chen LF, Huang YW, Wang RX, Zhang NJ, Li HJ, Liu SS, et al. PMID: 3877675.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    42. The gene frequency of serum albumin variants in Chinese and the electrophoretic characterization of several serum albumin variants. Sci Sin. 1981 Nov; 24(11):1597-602. Ying QL, Liang ZQ, Wu H, Wang LF. PMID: 7302558.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    43. [Studies on polymorphisms of blood proteins in Chinese populations. II. Study on polymorphism of serum transferrin in Chinese (author's transl)]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1981 Mar; 3(1):1-5. Ying QL, Liang CC, Wu H, Wang LF. PMID: 6458384.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
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