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    Kenneth Raymond Hallows, MD, PhD

    TitleProfessor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressMMR 1333 San Pablo Street
    Off Campus
    Los Angeles California 90033
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      Other Positions
      TitleDirector of The Usc/Ukro Kidney Research Center

      TitleChief, Division of Nephrology


      Collapse Overview 
      Collapse Overview
      Dr. Hallows is studying the metabolic control of kidney epithelial salt and water transport mechanisms with relevance to hypertension, acute kidney injury and chronic kidney disease. He is also studying the role of metabolic changes in autosomal dominant polycystic kidney disease and other kidney diseases at various levels.

      After completing his undergraduate training at Brown University, Dr. Hallows earned his PhD and MD degrees from the University of Rochester. He then went on to complete residency in internal medicine and then a fellowship in nephrology at the Hospital of the University of Pennsylvania. After spending a year as an instructor at the University of Pennsylvania, Dr. Hallows moved to the University of Pittsburgh as an assistant professor, then associate professor of medicine, before moving to the Keck School of Medicine of USC in 2015.


      Collapse Biography 
      Collapse Education and Training
      Brown University, Providence, RISc.B.05/1987Biophysics
      University of Rochester, Rochester, NYPh.D.10/1993Biophysics
      University of Rochester, Rochester, NYM.D.05/1995Medicine
      University of Pennsylvania, Philadelphia, PA06/1997Internal Medicine
      University of Pennsylvania, Philadelphia, PA06/2001Nephrology and Postdoctoral Fellowship
      Collapse Awards and Honors
      Brown University1983  - 1987CBS Merit Scholarship
      Brown University1987Susan Colver Rosenberger Prize in Biology
      University of Rochester1988Edward F. Adolph Prize in Physiology
      University of Rochester1988Walle J.H. Nauta Award in Neural Sciences
      University of Rochester 1992William F. Neuman Award in Biophysics
      Alpha Omega Alpha1994National Medical Honor Society
      National Kidney Foundation1999Renal Fellow Research Forum Prize
      University of Pennsylvania1999  - 2000J. Russell Elkinton Renal Fellow Teaching Award
      American Society of Nephrology2004Fellow
      American Society of Nephrology2006Carl W. Gottschalk Research Scholar Grantee
      American Physiological Society2009Lazaro J. Mandel Young Investigator Award

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      Collapse Required Scholarly Project Mentor

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows K, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. PMID: 28473772.
        View in: PubMed
      2. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows K, Nørregaard R. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 Oct 26; 6:35952. PMID: 27782167.
        View in: PubMed
      3. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows K. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 01; 311(5):F890-F900. PMID: 27534994.
        View in: PubMed
      4. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows K, Pastor-Soler NM. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 1; 310(11):F1216-28. PMID: 26911844.
        View in: PubMed
      5. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows K, Staub O, Subramanya AR. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep 1; 125(9):3433-48. PMID: 26241057.
        View in: PubMed
      6. Jiang C, Veon W, Li H, Hallows K, Roy P. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015 Sep 17; 14(18):2914-23. PMID: 26176334.
        View in: PubMed
      7. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows K, Singh P. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1; 309(5):F414-28. PMID: 26136559.
        View in: PubMed
      8. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows K, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. PMID: 25925251.
        View in: PubMed
      9. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows K, Erkan E. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. PMID: 25253241.
        View in: PubMed
      10. Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows K, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. PMID: 25232008.
        View in: PubMed
      11. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows K. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014; 18(5):501. PMID: 25575158.
        View in: PubMed
      12. Morrell ED, Kellum JA, Hallows K, Pastor-Soler NM. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. PMID: 24378526.
        View in: PubMed
      13. Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows K, Johnson JP. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. PMID: 24205069.
        View in: PubMed
      14. Singh T, Hallows K. Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7. PMID: 24118090.
        View in: PubMed
      15. Kleyman TR, Satlin LM, Hallows K. Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct 1; 123(10):4139-41. PMID: 24051382.
        View in: PubMed
      16. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows K, Brown D, Bouley R, Vilardaga JP. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60. PMID: 23935101.
        View in: PubMed
      17. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows K, Pastor-Soler NM. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 1; 305(7):F943-56. PMID: 23863464.
        View in: PubMed
      18. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows K, Kemp BE, Power DA. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F679-90. PMID: 23785098.
        View in: PubMed
      19. Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows K, Nolin TD. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. PMID: 23704302.
        View in: PubMed
      20. Pastor-Soler NM, Hallows K. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. PMID: 22801443.
        View in: PubMed
      21. King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows K. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400. PMID: 22869372.
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      22. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows K, Bhalla V. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. PMID: 21900244.
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      23. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows K, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. PMID: 21677144.
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      24. Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows K, Somlo S, Caplan MJ. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 8; 108(6):2462-7. PMID: 21262823.
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      25. Alzamora R, King JD, Hallows K. CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88. PMID: 21594802.
        View in: PubMed
      26. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows K. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. PMID: 20861072.
        View in: PubMed
      27. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows K, Foskett JK. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. PMID: 20655468.
        View in: PubMed
      28. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows K, McGaffin KR, Ahmad F. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. PMID: 20600102.
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      29. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows K, Pastor-Soler NM. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 6; 285(32):24676-85. PMID: 20525692.
        View in: PubMed
      30. Hallows K, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 9; 285(28):21671-8. PMID: 20466724.
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      31. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows K. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. PMID: 20462973.
        View in: PubMed
      32. Hallows K, Mount PF, Pastor-Soler NM, Power DA. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. PMID: 20181668.
        View in: PubMed
      33. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows K, Pastor-Soler NM. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. PMID: 20147366.
        View in: PubMed
      34. Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows K. AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. PMID: 19617399.
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      35. King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows K. AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. PMID: 19419994.
        View in: PubMed
      36. Hallows K, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. PMID: 19211918.
        View in: PubMed
      37. Hallows K, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. PMID: 19126549.
        View in: PubMed
      38. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows K. Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 2; 284(1):150-7. PMID: 18981174.
        View in: PubMed
      39. Bhalla V, Hallows K. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. PMID: 18753254.
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      40. Pastor-Soler NM, Hallows K, Smolak C, Gong F, Brown D, Breton S. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. PMID: 18160485.
        View in: PubMed
      41. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows K. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 8; 281(36):26159-69. PMID: 16844684.
        View in: PubMed
      42. Hallows K, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41. PMID: 16361706.
        View in: PubMed
      43. Hallows K. Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. PMID: 16046906.
        View in: PubMed
      44. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows K. Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 6; 280(18):17608-16. PMID: 15753079.
        View in: PubMed
      45. Hallows K, Kobinger GP, Wilson JM, Witters LA, Foskett JK. Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. PMID: 12519745.
        View in: PubMed
      46. Hallows K, McCane JE, Kemp BE, Witters LA, Foskett JK. Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004. PMID: 12427743.
        View in: PubMed
      47. Raghuram V, Hallows K, Foskett JK. Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81. PMID: 11917537.
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      48. Hallows K, Raghuram V, Kemp BE, Witters LA, Foskett JK. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21. PMID: 10862786.
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      49. Furst H, Hallows K, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4. PMID: 10768609.
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      50. Hallows K, Law FY, Packman CH, Knauf PA. Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71. PMID: 8698841.
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      51. Arreola J, Hallows K, Knauf PA. Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. PMID: 7485447.
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      52. Hallows K, Knauf PA. Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. PMID: 7943267.
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      53. Hallows K, Restrepo D, Knauf PA. Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. PMID: 7943268.
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      54. Hallows K, Frank RS. Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309. PMID: 1298447.
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      55. Hallows K, Packman CH, Knauf PA. Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. PMID: 1767817.
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      56. Leith JT, Hallows K, Arundel CM, Bliven SF. Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88. PMID: 3375444.
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      57. Hallows K, Bliven SF, Leith JT. Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8. PMID: 3340722.
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