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Female Protection Against Diabetic Kidney Disease Is Regulated by Kidney-Specific AMPK Activity. Diabetes. 2024 Jul 01; 73(7):1167-1177.
Lee HJ, Min L, Gao J, Matta S, Drel V, Saliba A, Tamayo I, Montellano R, Hejazi L, Maity S, Xu G, Grajeda BI, Roy S, Hallows KR, Choudhury GG, Kasinath BS, Sharma K. PMID: 38656940; PMCID: PMC11189830.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Oral delivery of nanomedicine for genetic kidney disease. PNAS Nexus. 2024 May; 3(5):pgae187.
Huang Y, Wang J, Mancino V, Pham J, O'Grady C, Li H, Jiang K, Chin D, Poon C, Ho PY, Gyarmati G, Peti-Peterdi J, Hallows KR, Chung EJ. PMID: 38807632; PMCID: PMC11131023.
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PubMed Mentions:
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Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Cell Stem Cell. 2024 Jun 06; 31(6):921-939.e17.
Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindström NO, McMahon AP, Li Z. PMID: 38692273; PMCID: PMC11162329.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Investigation of Basolateral Targeting Micelles for Drug Delivery Applications in Polycystic Kidney Disease. Biomacromolecules. 2024 May 13; 25(5):2749-2761.
Huang Y, Osouli A, Pham J, Mancino V, O'Grady C, Khan T, Chaudhuri B, Pastor-Soler NM, Hallows KR, Chung EJ. PMID: 38652072.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimals
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Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25.
Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z. PMID: 37293038; PMCID: PMC10245960.
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PubMed Mentions:
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In vitro delivery of mTOR inhibitors by kidney-targeted micelles for autosomal dominant polycystic kidney disease. SLAS Technol. 2023 08; 28(4):223-229.
Cox A, Tung M, Li H, Hallows KR, Chung EJ. PMID: 36804177; PMCID: PMC10439257.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Association of Longitudinal Urinary Metabolic Biomarkers With ADPKD Severity and Response to Metformin in TAME-PKD Clinical Trial Participants. Kidney Int Rep. 2023 Mar; 8(3):467-477.
Hallows KR, Abebe KZ, Li H, Saitta B, Althouse AD, Bae KT, Lalama CM, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 36938071; PMCID: PMC10014337.
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PubMed Mentions:
4
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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice. Front Mol Biosci. 2022; 9:1001941.
Hallows KR, Li H, Saitta B, Sepehr S, Huang P, Pham J, Wang J, Mancino V, Chung EJ, Pinkosky SL, Pastor-Soler NM. PMID: 36504724; PMCID: PMC9730828.
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PubMed Mentions:
1
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Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 04; 17(4):507-517.
Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. PMID: 35314480; PMCID: PMC8993480.
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PubMed Mentions:
14 Fields:
Translation:
HumansAnimals
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Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F27-F41.
Pastor-Soler NM, Li H, Pham J, Rivera D, Ho PY, Mancino V, Saitta B, Hallows KR. PMID: 34806449.
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PubMed Mentions:
27 Fields:
Translation:
Animals
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Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD). Kidney Int. 2021 09; 100(3):684-696.
Perrone RD, Abebe KZ, Watnick TJ, Althouse AD, Hallows KR, Lalama CM, Miskulin DC, Seliger SL, Tao C, Harris PC, Bae KT. PMID: 34186056; PMCID: PMC8801184.
View in:
PubMed Mentions:
27 Fields:
Translation:
Humans
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Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641.
Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z. PMID: 34131121; PMCID: PMC8206157.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants. Kidney360. 2021 May; 2(5):795-808.
Hallows KR, Althouse AD, Li H, Saitta B, Abebe KZ, Bae KT, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 34316721; PMCID: PMC8312696.
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PubMed Mentions:
8 Fields:
Translation:
HumansCTClinical Trials
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Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial. Kidney360. 2020 Dec 31; 1(12):1363-1372.
Seliger SL, Watnick T, Althouse AD, Perrone RD, Abebe KZ, Hallows KR, Miskulin DC, Bae KT. PMID: 33768205; PMCID: PMC7990324.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCTClinical Trials
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Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease. J Control Release. 2021 01 10; 329:1198-1209.
Wang J, Chin D, Poon C, Mancino V, Pham J, Li H, Ho PY, Hallows KR, Chung EJ. PMID: 33127449; PMCID: PMC7904655.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimals
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AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020 08; 16(8):1550-1552.
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 32597364; PMCID: PMC7469532.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness. FASEB J. 2020 05; 34(5):7036-7057.
Jin K, Ma Y, Manrique-Caballero CL, Li H, Emlet DR, Li S, Baty CJ, Wen X, Kim-Campbell N, Frank A, Menchikova EV, Pastor-Soler NM, Hallows KR, Jackson EK, Shiva S, Pinsky MR, Zuckerbraun BS, Kellum JA, Gómez H. PMID: 32246808.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020 03 05; 77(5):951-969.e9.
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 31995728; PMCID: PMC7785494.
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PubMed Mentions:
78 Fields:
Translation:
HumansAnimalsCells
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AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1513-F1525.
Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR. PMID: 31566435; PMCID: PMC6962512.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimalsCells
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Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells. Methods Cell Biol. 2019; 153:185-203.
Saitta B, Jalili MF, Zohoorkari H, Rao R, Hallows KR, Baty CJ, Pastor-Soler NM. PMID: 31395379.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury. Am J Kidney Dis. 2019 03; 73(3):429-431.
Unruh M, Wagner B, Hallows KR. PMID: 30241958; PMCID: PMC6389413.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624.
Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. PMID: 29858246; PMCID: PMC6065188.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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"First do no harm": kidney drug targeting to avoid toxicity in ADPKD. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F535-F536.
Chung EJ, Hallows KR. PMID: 29846111.
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PubMed Mentions:
3 Fields:
Translation:
Animals
-
A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2018; 47(5):352-360.
Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT. PMID: 29779024; PMCID: PMC6010317.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansCTClinical Trials
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Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383.
Rajani R, Pastor-Soler NM, Hallows KR. PMID: 28614117.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227.
Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. PMID: 28473772; PMCID: PMC5397526.
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PubMed Mentions:
11
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Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952.
Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. PMID: 27782167; PMCID: PMC5080611.
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PubMed Mentions:
17 Fields:
Translation:
Animals
-
Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900.
Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. PMID: 27534994; PMCID: PMC5130465.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28.
Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. PMID: 26911844; PMCID: PMC4935778.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48.
Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. PMID: 26241057; PMCID: PMC4588284.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23.
Jiang C, Veon W, Li H, Hallows KR, Roy P. PMID: 26176334; PMCID: PMC4825560.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28.
Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. PMID: 26136559; PMCID: PMC4556888.
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PubMed Mentions:
35 Fields:
Translation:
Animals
-
Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62.
Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. PMID: 25925251; PMCID: PMC4469889.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9.
Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. PMID: 25253241; PMCID: PMC4269696.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812.
Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. PMID: 25232008; PMCID: PMC4230785.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501.
Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. PMID: 25575158; PMCID: PMC4729166.
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PubMed Mentions:
33 Fields:
Translation:
Humans
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Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9.
Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. PMID: 24378526; PMCID: PMC4071050.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019.
Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. PMID: 24205069; PMCID: PMC3812018.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7.
Singh T, Hallows KR. PMID: 24118090.
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PubMed Mentions:
3 Fields:
Translation:
Humans
-
Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct; 123(10):4139-41.
Kleyman TR, Satlin LM, Hallows KR. PMID: 24051382; PMCID: PMC3786722.
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PubMed Mentions:
12 Fields:
Translation:
Animals
-
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60.
Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. PMID: 23935101; PMCID: PMC3784700.
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PubMed Mentions:
89 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56.
Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 23863464; PMCID: PMC3798744.
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PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90.
Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. PMID: 23785098; PMCID: PMC3761205.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9.
Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. PMID: 23704302; PMCID: PMC3805068.
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PubMed Mentions:
22 Fields:
Translation:
Humans
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AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33.
Pastor-Soler NM, Hallows KR. PMID: 22801443.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400.
King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. PMID: 22869372; PMCID: PMC3460441.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40.
Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244; PMCID: PMC3199524.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33.
Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. PMID: 21677144; PMCID: PMC3174547.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7.
Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. PMID: 21262823; PMCID: PMC3038735.
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PubMed Mentions:
144 Fields:
Translation:
HumansAnimalsCells
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CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88.
Alzamora R, King JD, Hallows KR. PMID: 21594802.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19.
Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. PMID: 20861072; PMCID: PMC3006313.
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PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83.
Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. PMID: 20655468; PMCID: PMC2911450.
View in:
PubMed Mentions:
501 Fields:
Translation:
AnimalsCells
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SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92.
Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. PMID: 20600102; PMCID: PMC2932762.
View in:
PubMed Mentions:
40 Fields:
Translation:
HumansAnimals
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PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85.
Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20525692; PMCID: PMC2915704.
View in:
PubMed Mentions:
50 Fields:
Translation:
HumansAnimalsCells
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Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8.
Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77.
Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. PMID: 20462973; PMCID: PMC2904179.
View in:
PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77.
Hallows KR, Mount PF, Pastor-Soler NM, Power DA. PMID: 20181668; PMCID: PMC2867412.
View in:
PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9.
Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20147366; PMCID: PMC2867405.
View in:
PubMed Mentions:
49 Fields:
Translation:
Animals
-
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84.
Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. PMID: 19617399; PMCID: PMC2891496.
View in:
PubMed Mentions:
58 Fields:
Translation:
HumansCells
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AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101.
King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. PMID: 19419994; PMCID: PMC2711654.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81.
Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. PMID: 19211918; PMCID: PMC2670645.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83.
Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. PMID: 19126549; PMCID: PMC2645828.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
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Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 02; 284(1):150-157.
Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. PMID: 18981174; PMCID: PMC2610498.
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25 Fields:
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HumansAnimalsCells
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Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54.
Bhalla V, Hallows KR. PMID: 18753254.
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128 Fields:
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Humans
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Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94.
Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. PMID: 18160485; PMCID: PMC4303256.
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57 Fields:
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AnimalsCells
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AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69.
Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
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88 Fields:
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HumansAnimalsCells
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Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41.
Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. PMID: 16361706.
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33 Fields:
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HumansCells
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Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71.
Hallows KR. PMID: 16046906.
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38 Fields:
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HumansAnimalsCells
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Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 06; 280(18):17608-16.
Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. PMID: 15753079.
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78 Fields:
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HumansAnimalsCells
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Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308.
Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK. PMID: 12519745.
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56 Fields:
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HumansAnimalsCells
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Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004.
Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK. PMID: 12427743.
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38 Fields:
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HumansAnimalsCells
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Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81.
Raghuram V, Hallows KR, Foskett JK. PMID: 11917537.
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1 Fields:
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HumansCells
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Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21.
Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK. PMID: 10862786; PMCID: PMC378514.
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90 Fields:
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HumansAnimalsCells
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The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4.
Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. PMID: 10768609.
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PubMed Mentions:
38 Fields:
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Humans
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Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71.
Hallows KR, Law FY, Packman CH, Knauf PA. PMID: 8698841.
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13 Fields:
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HumansCells
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Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72.
Arreola J, Hallows KR, Knauf PA. PMID: 7485447.
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2 Fields:
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HumansCells
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Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66.
Hallows KR, Restrepo D, Knauf PA. PMID: 7943268.
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2 Fields:
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HumansCells
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Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56.
Hallows KR, Knauf PA. PMID: 7943267.
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PubMed Mentions:
3 Fields:
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HumansCells
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Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309.
Hallows KR, Frank RS. PMID: 1298447.
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4 Fields:
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HumansCells
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Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61.
Hallows KR, Packman CH, Knauf PA. PMID: 1767817.
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18 Fields:
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HumansCells
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Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88.
Leith JT, Hallows KT, Arundel CM, Bliven SF. PMID: 3375444.
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1 Fields:
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HumansCells
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Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8.
Hallows KR, Bliven SF, Leith JT. PMID: 3340722.
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1 Fields:
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HumansCells