Kenneth Raymond Hallows, MD, PhD

Title(s)Professor of Medicine
SchoolKeck School of Medicine of USC
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    Other Positions
    Title(s)Director of The Usc/Ukro Kidney Research Center

    Title(s)Chief, Division of Nephrology

    Collapse Biography 
    Collapse Education and Training
    Brown University, Providence, RISc.B.05/1987Biophysics
    University of Rochester, Rochester, NYPh.D.10/1993Biophysics
    University of Rochester, Rochester, NYM.D.05/1995Medicine
    University of Pennsylvania, Philadelphia, PA06/1997Internal Medicine
    University of Pennsylvania, Philadelphia, PA06/2001Nephrology and Postdoctoral Fellowship
    Collapse Awards and Honors
    Brown University1983  - 1987CBS Merit Scholarship
    Brown University1987Susan Colver Rosenberger Prize in Biology
    University of Rochester1988Edward F. Adolph Prize in Physiology
    University of Rochester1988Walle J.H. Nauta Award in Neural Sciences
    University of Rochester 1992William F. Neuman Award in Biophysics
    Alpha Omega Alpha1994National Medical Honor Society
    National Kidney Foundation1999Renal Fellow Research Forum Prize
    University of Pennsylvania1999  - 2000J. Russell Elkinton Renal Fellow Teaching Award
    American Society of Nephrology2004Fellow
    American Society of Nephrology2006Carl W. Gottschalk Research Scholar Grantee
    American Physiological Society2009Lazaro J. Mandel Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Hallows is studying the metabolic control of kidney epithelial salt and water transport mechanisms with relevance to hypertension, acute kidney injury and chronic kidney disease. He is also studying the role of metabolic changes in autosomal dominant polycystic kidney disease and other kidney diseases at various levels.

    After completing his undergraduate training at Brown University, Dr. Hallows earned his PhD and MD degrees from the University of Rochester. He then went on to complete residency in internal medicine and then a fellowship in nephrology at the Hospital of the University of Pennsylvania. After spending a year as an instructor at the University of Pennsylvania, Dr. Hallows moved to the University of Pittsburgh as an assistant professor, then associate professor of medicine, before moving to the Keck School of Medicine of USC in 2015.

    Collapse Research 
    Collapse Research Activities and Funding
    2017 Western Epithelial Biology Society (WEBS) meeting
    NIH/NIDDK R13DK113785Mar 1, 2017 - Feb 28, 2018
    Role: Principal Investigator
    Mechanisms of ENaC Regulation by AMP-activated Kinase
    NIH/NIDDK R03DK068390Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    NIH/NIDDK K08DK059477Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    NIH/NIDDK F32DK009994Sep 21, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Unruh M, Wagner B, Hallows KR. MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury. Am J Kidney Dis. 2018 Sep 18. PMID: 30241958.
      View in: PubMed
    2. Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. ß1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624. PMID: 29858246.
      View in: PubMed
    3. Chung EJ, Hallows KR. "First do no harm": kidney drug targeting to avoid toxicity in ADPKD. Am J Physiol Renal Physiol. 2018 Sep 01; 315(3):F535-F536. PMID: 29846111.
      View in: PubMed
    4. Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT. A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2018; 47(5):352-360. PMID: 29779024.
      View in: PubMed
    5. Rajani R, Pastor-Soler NM, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383. PMID: 28614117.
      View in: PubMed
    6. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. PMID: 28473772.
      View in: PubMed
    7. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952. PMID: 27782167.
      View in: PubMed
    8. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. PMID: 27534994.
      View in: PubMed
    9. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. PMID: 26911844.
      View in: PubMed
    10. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48. PMID: 26241057; PMCID: PMC4588284.
    11. Jiang C, Veon W, Li H, Hallows KR, Roy P. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23. PMID: 26176334; PMCID: PMC4825560.
    12. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. PMID: 26136559; PMCID: PMC4556888.
    13. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. PMID: 25925251; PMCID: PMC4469889.
    14. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. PMID: 25253241; PMCID: PMC4269696.
    15. Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. PMID: 25232008; PMCID: PMC4230785.
    16. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501. PMID: 25575158; PMCID: PMC4729166.
    17. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. PMID: 24378526; PMCID: PMC4071050.
    18. Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. PMID: 24205069.
      View in: PubMed
    19. Singh T, Hallows KR. Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7. PMID: 24118090.
      View in: PubMed
    20. Kleyman TR, Satlin LM, Hallows KR. Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct; 123(10):4139-41. PMID: 24051382; PMCID: PMC3786722.
    21. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60. PMID: 23935101; PMCID: PMC3784700.
    22. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. PMID: 23863464; PMCID: PMC3798744.
    23. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. PMID: 23785098; PMCID: PMC3761205.
    24. Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. PMID: 23704302; PMCID: PMC3805068.
    25. Pastor-Soler NM, Hallows KR. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. PMID: 22801443.
      View in: PubMed
    26. King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400. PMID: 22869372; PMCID: PMC3460441.
    27. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. PMID: 21900244; PMCID: PMC3199524.
    28. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. PMID: 21677144; PMCID: PMC3174547.
    29. Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7. PMID: 21262823; PMCID: PMC3038735.
    30. Alzamora R, King JD, Hallows KR. CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88. PMID: 21594802.
      View in: PubMed
    31. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. PMID: 20861072; PMCID: PMC3006313.
    32. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. PMID: 20655468; PMCID: PMC2911450.
    33. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. PMID: 20600102; PMCID: PMC2932762.
    34. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85. PMID: 20525692.
      View in: PubMed
    35. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. PMID: 20466724; PMCID: PMC2898378.
    36. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. PMID: 20462973; PMCID: PMC2904179.
    37. Hallows KR, Mount PF, Pastor-Soler NM, Power DA. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. PMID: 20181668.
      View in: PubMed
    38. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. PMID: 20147366.
      View in: PubMed
    39. Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. PMID: 19617399; PMCID: PMC2891496.
    40. King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. PMID: 19419994.
      View in: PubMed
    41. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. PMID: 19211918; PMCID: PMC2670645.
    42. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. PMID: 19126549; PMCID: PMC2645828.
    43. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 02; 284(1):150-7. PMID: 18981174; PMCID: PMC2610498.
    44. Bhalla V, Hallows KR. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. PMID: 18753254.
      View in: PubMed
    45. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. PMID: 18160485; PMCID: PMC4303256.
    46. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. PMID: 16844684.
      View in: PubMed
    47. Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41. PMID: 16361706.
      View in: PubMed
    48. Hallows KR. Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. PMID: 16046906.
      View in: PubMed
    49. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 06; 280(18):17608-16. PMID: 15753079.
      View in: PubMed
    50. Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK. Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. PMID: 12519745.
      View in: PubMed
    51. Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK. Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004. PMID: 12427743.
      View in: PubMed
    52. Raghuram V, Hallows KR, Foskett JK. Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81. PMID: 11917537.
      View in: PubMed
    53. Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21. PMID: 10862786; PMCID: PMC378514.
    54. Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4. PMID: 10768609.
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    55. Hallows KR, Law FY, Packman CH, Knauf PA. Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71. PMID: 8698841.
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    56. Arreola J, Hallows KR, Knauf PA. Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. PMID: 7485447.
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    57. Hallows KR, Knauf PA. Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. PMID: 7943267.
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    58. Hallows KR, Restrepo D, Knauf PA. Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. PMID: 7943268.
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    59. Hallows KR, Frank RS. Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309. PMID: 1298447.
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    60. Hallows KR, Packman CH, Knauf PA. Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. PMID: 1767817.
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    61. Leith JT, Hallows KT, Arundel CM, Bliven SF. Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88. PMID: 3375444.
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    62. Hallows KR, Bliven SF, Leith JT. Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8. PMID: 3340722.
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