Kenneth Raymond Hallows, MD, PhD, FASN

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
AddressMMR 628 1333 San Pablo Street
Off Campus
Los Angeles CA 90033
vCardDownload vCard
    Other Positions
    Title(s)Director of the USC/UKRO Kidney Research Center

    Title(s)Chief, Division of Nephrology


    Collapse Biography 
    Collapse Education and Training
    Brown University, Providence, RISc.B.05/1987Biophysics
    University of Rochester, Rochester, NYPh.D.10/1993Biophysics
    University of Rochester, Rochester, NYM.D.05/1995Medicine
    University of Pennsylvania, Philadelphia, PA06/1997Internal Medicine
    University of Pennsylvania, Philadelphia, PA06/2001Nephrology and Postdoctoral Fellowship
    Collapse Awards and Honors
    Brown University1983  - 1987CBS Merit Scholarship
    Brown University1987Susan Colver Rosenberger Prize in Biology
    University of Rochester1988Edward F. Adolph Prize in Physiology
    University of Rochester1988Walle J.H. Nauta Award in Neural Sciences
    University of Rochester 1992William F. Neuman Award in Biophysics
    Alpha Omega Alpha1994National Medical Honor Society
    National Kidney Foundation1999Renal Fellow Research Forum Prize
    University of Pennsylvania1999  - 2000J. Russell Elkinton Renal Fellow Teaching Award
    American Society of Nephrology2004Fellow
    American Society of Nephrology2006Carl W. Gottschalk Research Scholar Grantee
    American Physiological Society2009Lazaro J. Mandel Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Hallows is studying the metabolic control of kidney epithelial salt and water transport mechanisms with relevance to hypertension, acute kidney injury and chronic kidney disease. He is also studying the role of metabolic changes in autosomal dominant polycystic kidney disease and other kidney diseases at various levels.

    After completing his undergraduate training at Brown University, Dr. Hallows earned his PhD and MD degrees from the University of Rochester. He then went on to complete residency in internal medicine and then a fellowship in nephrology at the Hospital of the University of Pennsylvania. After spending a year as an instructor at the University of Pennsylvania, Dr. Hallows moved to the University of Pittsburgh as an assistant professor, then associate professor of medicine, before moving to the Keck School of Medicine of USC in 2015.

    Collapse Research 
    Collapse Research Activities and Funding
    The Synthetic Kidney: A Revolutionary Solution for the Shortage of Kidneys for Transplantation
    NIH/NIDDK DP2 DK135739Sep 15, 2022 - Aug 31, 2027
    Role: Co-Investigator
    Description: With an interdisciplinary research team covering expertise of stem cell, kidney development, kidney physiology, animal models and bioengineering, we will 1) generate a scaled-up transplantable synthetic kidney by combining stem cell technologies and bioengineering strategies; 2) evaluate the growth, differentiation, vascularization, and functional maturation of the transplanted synthetic kidney; and 3) determine the therapeutic potential of the synthetic kidney in CKD and ESRD animal models.
    Bempedoic Acid as a Novel Therapy in Polycystic Kidney Disease
    Esperion Therapeutics, Inc. Dec 1, 2019 - Jun 30, 2023
    Role: Co-Principal Investigator
    Description: The aims are to: (1) test the in vitro effects of bempedoic acid (BA), either alone or in combination with tolvaptan, on cystogenesis and key disease parameters of PKD1-null kidney cells; (2) characterize kidney disease severity in vehicle control ± BA ± tolvaptan treated mice in an inducible, rapid ADPKD mouse model; and (3) characterize ADPKD disease severity and gene expression profiles with BA combination treatments in an inducible, slow ADPKD mouse model.
    Effects of Combination Therapy with Tolvaptan and the Farnesoid X Receptor Agonist INT-747 on Hepatotoxicity, Metabolic and Injury Biomarkers, and Cystogenesis in ADPKD
    Otsuka Pharmaceuticals OAK-ISS-2018-000317Jul 1, 2019 - Jun 30, 2021
    Role: Principal Investigator
    Description: The aims are to: (1) investigate the in vitro dose-response and time course treatment effects of tolvaptan and INT-747, either alone or in combination, on various parameters associated with DILI in human hepatocyte cell lines; and (2) investigate the effects of treatment with tolvaptan ± INT-747 vs. vehicle on the development and severity of ADPKD and liver toxicity in vivo in an inducible Pkd1-/- aggressive ADPKD mouse model.
    A Revolutionary Approach for Polycystic Kidney Disease: Oral Nanotherapeutics
    NIH/NIDDK DP2 DK121328Sep 30, 2018 - Aug 31, 2023
    Role: Co-Investigator
    Description: The aims of this project are to: 1) develop nanoparticles to actively target diseased kidneys; 2) incorporate metformin and mTOR inhibitors into nanoparticles and optimize release profiles; 3) develop nanotherapeutics for oral delivery; and 4) evaluate nanotherapeutics in mice models of ADPKD.
    2017 Western Epithelial Biology Society (WEBS) meeting
    NIH R13DK113785Mar 1, 2017 - Feb 28, 2018
    Role: Principal Investigator
    Metformin as a Novel Therapy for Autosomal Dominant Polycystic Kidney Disease (Clinical Trial Award)
    U.S. Department of Defense W81XWH-15-1-0663Sep 30, 2015 - Sep 29, 2021
    Role: Co-Principal Investigator
    Description: This multi-center randomized controlled clinical trial investigated the primary endpoints of safety and tolerability and the secondary endpoints of efficacy for the AMPK activator metformin as a novel therapeutic in patients with autosomal dominant polycystic kidney disease (ADPKD) patients. Dr. Hallows' role as co-PI was to oversee the measurement and analysis of various metabolic biomarkers from patient urine samples throughout the study.
    Energy Pathways as Novel Targets for the Therapy of Autosomal Dominant Polycystic Kidney Disease
    U.S. Department of Defense W81XWH-15-1-0420Sep 1, 2015 - Aug 31, 2018
    Role: Principal Investigator
    Description: We have previously shown that activating AMPK with metformin slows cyst growth in in vitro and in vivo models of ADPKD. Salicylates and statins have been shown to synergize with metformin in activating AMPK. In Aim 1 we will assess the potential of treatment with dichloroacetic acid, metformin, salicylates and statins, alone or in combination, to correct the perturbed energy metabolism in ADPKD and to slow cyst growth in vitro and in vivo. In Aim 2 we will seek to identify metabolism-related biomarkers in vitro and in vivo, and to determine the extent to which they accurately reflect disease severity in samples obtained from human ADPKD patients.
    Cellular Physiology Core
    NIH/NIDDK P30DK079307Aug 1, 2013 - Jul 31, 2015
    Role: Principal Investigator
    Description: The Pittsburgh Center for Kidney Research "Cellular Physiology Core" provides mechanistic analyses of the functions of membrane transport and other associated proteins through a series of graded in vitro model systems. This Core interfaces with and complements the other Cores and has the overall goal of elucidating at a molecular and cellular level the function and regulation of key proteins involved in kidney diseases.
    Mechanisms and Relevance of Sodium Transport Regulation by AMPK
    NIH/NIDDK R01 DK075048Feb 1, 2007 - Jul 31, 2017
    Role: Principal Investigator
    Mechanisms of ENaC Regulation by AMP-activated Kinase
    NIH R03DK068390Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    MECHANISM OF INHIBITION OF CFTR BY AMP-ACTIVATED KINASE
    NIH K08DK059477Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INTERACTION OF AMP-KINASE WITH CFTR C1 CHANNEL
    NIH F32DK009994Sep 21, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Female Protection Against Diabetic Kidney Disease Is Regulated by Kidney-Specific AMPK Activity. Diabetes. 2024 Jul 01; 73(7):1167-1177. Lee HJ, Min L, Gao J, Matta S, Drel V, Saliba A, Tamayo I, Montellano R, Hejazi L, Maity S, Xu G, Grajeda BI, Roy S, Hallows KR, Choudhury GG, Kasinath BS, Sharma K. PMID: 38656940; PMCID: PMC11189830.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    2. Oral delivery of nanomedicine for genetic kidney disease. PNAS Nexus. 2024 May; 3(5):pgae187. Huang Y, Wang J, Mancino V, Pham J, O'Grady C, Li H, Jiang K, Chin D, Poon C, Ho PY, Gyarmati G, Peti-Peterdi J, Hallows KR, Chung EJ. PMID: 38807632; PMCID: PMC11131023.
      View in: PubMed   Mentions:
    3. Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease. Cell Stem Cell. 2024 Jun 06; 31(6):921-939.e17. Huang B, Zeng Z, Kim S, Fausto CC, Koppitch K, Li H, Li Z, Chen X, Guo J, Zhang CC, Ma T, Medina P, Schreiber ME, Xia MW, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, Lindström NO, McMahon AP, Li Z. PMID: 38692273; PMCID: PMC11162329.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Investigation of Basolateral Targeting Micelles for Drug Delivery Applications in Polycystic Kidney Disease. Biomacromolecules. 2024 May 13; 25(5):2749-2761. Huang Y, Osouli A, Pham J, Mancino V, O'Grady C, Khan T, Chaudhuri B, Pastor-Soler NM, Hallows KR, Chung EJ. PMID: 38652072.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    5. Modeling kidney development, disease, and plasticity with clonal expandable nephron progenitor cells and nephron organoids. bioRxiv. 2023 May 25. Huang B, Zeng Z, Li H, Li Z, Chen X, Guo J, Zhang CC, Schreiber ME, Vonk AC, Xiang T, Patel T, Li Y, Parvez RK, Der B, Chen JH, Liu Z, Thornton ME, Grubbs BH, Diao Y, Dou Y, Gnedeva K, Lindström NO, Ying Q, Pastor-Soler NM, Fei T, Hallows KR, McMahon AP, Li Z. PMID: 37293038; PMCID: PMC10245960.
      View in: PubMed   Mentions:
    6. In vitro delivery of mTOR inhibitors by kidney-targeted micelles for autosomal dominant polycystic kidney disease. SLAS Technol. 2023 08; 28(4):223-229. Cox A, Tung M, Li H, Hallows KR, Chung EJ. PMID: 36804177; PMCID: PMC10439257.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    7. Association of Longitudinal Urinary Metabolic Biomarkers With ADPKD Severity and Response to Metformin in TAME-PKD Clinical Trial Participants. Kidney Int Rep. 2023 Mar; 8(3):467-477. Hallows KR, Abebe KZ, Li H, Saitta B, Althouse AD, Bae KT, Lalama CM, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 36938071; PMCID: PMC10014337.
      View in: PubMed   Mentions: 5  
    8. Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice. Front Mol Biosci. 2022; 9:1001941. Hallows KR, Li H, Saitta B, Sepehr S, Huang P, Pham J, Wang J, Mancino V, Chung EJ, Pinkosky SL, Pastor-Soler NM. PMID: 36504724; PMCID: PMC9730828.
      View in: PubMed   Mentions: 1  
    9. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 04; 17(4):507-517. Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. PMID: 35314480; PMCID: PMC8993480.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimals
    10. Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F27-F41. Pastor-Soler NM, Li H, Pham J, Rivera D, Ho PY, Mancino V, Saitta B, Hallows KR. PMID: 34806449.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    11. Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD). Kidney Int. 2021 09; 100(3):684-696. Perrone RD, Abebe KZ, Watnick TJ, Althouse AD, Hallows KR, Lalama CM, Miskulin DC, Seliger SL, Tao C, Harris PC, Bae KT. PMID: 34186056; PMCID: PMC8801184.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    12. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641. Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z. PMID: 34131121; PMCID: PMC8206157.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    13. Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants. Kidney360. 2021 May; 2(5):795-808. Hallows KR, Althouse AD, Li H, Saitta B, Abebe KZ, Bae KT, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 34316721; PMCID: PMC8312696.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    14. Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial. Kidney360. 2020 Dec 31; 1(12):1363-1372. Seliger SL, Watnick T, Althouse AD, Perrone RD, Abebe KZ, Hallows KR, Miskulin DC, Bae KT. PMID: 33768205; PMCID: PMC7990324.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    15. Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease. J Control Release. 2021 01 10; 329:1198-1209. Wang J, Chin D, Poon C, Mancino V, Pham J, Li H, Ho PY, Hallows KR, Chung EJ. PMID: 33127449; PMCID: PMC7904655.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    16. AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020 08; 16(8):1550-1552. Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 32597364; PMCID: PMC7469532.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    17. Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness. FASEB J. 2020 05; 34(5):7036-7057. Jin K, Ma Y, Manrique-Caballero CL, Li H, Emlet DR, Li S, Baty CJ, Wen X, Kim-Campbell N, Frank A, Menchikova EV, Pastor-Soler NM, Hallows KR, Jackson EK, Shiva S, Pinsky MR, Zuckerbraun BS, Kellum JA, Gómez H. PMID: 32246808.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    18. AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020 03 05; 77(5):951-969.e9. Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 31995728; PMCID: PMC7785494.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansAnimalsCells
    19. AMPK phosphorylation of the β1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1513-F1525. Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR. PMID: 31566435; PMCID: PMC6962512.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    20. Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells. Methods Cell Biol. 2019; 153:185-203. Saitta B, Jalili MF, Zohoorkari H, Rao R, Hallows KR, Baty CJ, Pastor-Soler NM. PMID: 31395379.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    21. MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury. Am J Kidney Dis. 2019 03; 73(3):429-431. Unruh M, Wagner B, Hallows KR. PMID: 30241958; PMCID: PMC6389413.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624. Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. PMID: 29858246; PMCID: PMC6065188.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    23. "First do no harm": kidney drug targeting to avoid toxicity in ADPKD. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F535-F536. Chung EJ, Hallows KR. PMID: 29846111.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    24. A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2018; 47(5):352-360. Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT. PMID: 29779024; PMCID: PMC6010317.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCTClinical Trials
    25. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383. Rajani R, Pastor-Soler NM, Hallows KR. PMID: 28614117.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    26. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. PMID: 28473772; PMCID: PMC5397526.
      View in: PubMed   Mentions: 11  
    27. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. PMID: 27782167; PMCID: PMC5080611.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    28. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. PMID: 27534994; PMCID: PMC5130465.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    29. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. PMID: 26911844; PMCID: PMC4935778.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    30. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. PMID: 26241057; PMCID: PMC4588284.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    31. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23. Jiang C, Veon W, Li H, Hallows KR, Roy P. PMID: 26176334; PMCID: PMC4825560.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    32. Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. PMID: 26136559; PMCID: PMC4556888.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    33. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. PMID: 25925251; PMCID: PMC4469889.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. PMID: 25253241; PMCID: PMC4269696.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    35. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. PMID: 25232008; PMCID: PMC4230785.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. PMID: 25575158; PMCID: PMC4729166.
      View in: PubMed   Mentions: 35     Fields:    Translation:Humans
    37. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. PMID: 24378526; PMCID: PMC4071050.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    38. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. PMID: 24205069; PMCID: PMC3812018.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    39. Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7. Singh T, Hallows KR. PMID: 24118090.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    40. Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct; 123(10):4139-41. Kleyman TR, Satlin LM, Hallows KR. PMID: 24051382; PMCID: PMC3786722.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    41. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. PMID: 23935101; PMCID: PMC3784700.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    42. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 23863464; PMCID: PMC3798744.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    43. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. PMID: 23785098; PMCID: PMC3761205.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    44. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. PMID: 23704302; PMCID: PMC3805068.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    45. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. Pastor-Soler NM, Hallows KR. PMID: 22801443.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    46. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400. King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. PMID: 22869372; PMCID: PMC3460441.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    47. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244; PMCID: PMC3199524.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    48. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. PMID: 21677144; PMCID: PMC3174547.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    49. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7. Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. PMID: 21262823; PMCID: PMC3038735.
      View in: PubMed   Mentions: 148     Fields:    Translation:HumansAnimalsCells
    50. CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88. Alzamora R, King JD, Hallows KR. PMID: 21594802.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    51. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. PMID: 20861072; PMCID: PMC3006313.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    52. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. PMID: 20655468; PMCID: PMC2911450.
      View in: PubMed   Mentions: 505     Fields:    Translation:AnimalsCells
    53. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. PMID: 20600102; PMCID: PMC2932762.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimals
    54. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20525692; PMCID: PMC2915704.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    55. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    56. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. PMID: 20462973; PMCID: PMC2904179.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    57. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. Hallows KR, Mount PF, Pastor-Soler NM, Power DA. PMID: 20181668; PMCID: PMC2867412.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    58. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20147366; PMCID: PMC2867405.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    59. AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. PMID: 19617399; PMCID: PMC2891496.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    60. AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. PMID: 19419994; PMCID: PMC2711654.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    61. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. PMID: 19211918; PMCID: PMC2670645.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    62. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. PMID: 19126549; PMCID: PMC2645828.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    63. Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 02; 284(1):150-157. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. PMID: 18981174; PMCID: PMC2610498.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    64. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. Bhalla V, Hallows KR. PMID: 18753254.
      View in: PubMed   Mentions: 129     Fields:    Translation:Humans
    65. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. PMID: 18160485; PMCID: PMC4303256.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    66. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
      View in: PubMed   Mentions: 88     Fields:    Translation:HumansAnimalsCells
    67. Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41. Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. PMID: 16361706.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    68. Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. Hallows KR. PMID: 16046906.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    69. Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 06; 280(18):17608-16. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. PMID: 15753079.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    70. Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK. PMID: 12519745.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimalsCells
    71. Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004. Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK. PMID: 12427743.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    72. Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81. Raghuram V, Hallows KR, Foskett JK. PMID: 11917537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    73. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21. Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK. PMID: 10862786; PMCID: PMC378514.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    74. The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4. Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. PMID: 10768609.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    75. Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71. Hallows KR, Law FY, Packman CH, Knauf PA. PMID: 8698841.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    76. Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. Arreola J, Hallows KR, Knauf PA. PMID: 7485447.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    77. Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. Hallows KR, Knauf PA. PMID: 7943267.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    78. Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. Hallows KR, Restrepo D, Knauf PA. PMID: 7943268.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    79. Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309. Hallows KR, Frank RS. PMID: 1298447.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    80. Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. Hallows KR, Packman CH, Knauf PA. PMID: 1767817.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    81. Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88. Leith JT, Hallows KT, Arundel CM, Bliven SF. PMID: 3375444.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    82. Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8. Hallows KR, Bliven SF, Leith JT. PMID: 3340722.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    Kenneth's Networks
    Concepts (415)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (15)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

    This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.