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In vitro delivery of mTOR inhibitors by kidney-targeted micelles for autosomal dominant polycystic kidney disease. SLAS Technol. 2023 Feb 19.
Cox A, Tung M, Li H, Hallows KR, Chung EJ. PMID: 36804177.
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PubMed Mentions: Fields:
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Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice. Front Mol Biosci. 2022; 9:1001941.
Hallows KR, Li H, Saitta B, Sepehr S, Huang P, Pham J, Wang J, Mancino V, Chung EJ, Pinkosky SL, Pastor-Soler NM. PMID: 36504724; PMCID: PMC9730828.
View in:
PubMed Mentions:
1
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Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 04; 17(4):507-517.
Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. PMID: 35314480; PMCID: PMC8993480.
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PubMed Mentions:
4 Fields:
Translation:
HumansAnimals
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Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F27-F41.
Pastor-Soler NM, Li H, Pham J, Rivera D, Ho PY, Mancino V, Saitta B, Hallows KR. PMID: 34806449.
View in:
PubMed Mentions:
12 Fields:
Translation:
Animals
-
Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD). Kidney Int. 2021 09; 100(3):684-696.
Perrone RD, Abebe KZ, Watnick TJ, Althouse AD, Hallows KR, Lalama CM, Miskulin DC, Seliger SL, Tao C, Harris PC, Bae KT. PMID: 34186056; PMCID: PMC8801184.
View in:
PubMed Mentions:
16 Fields:
Translation:
Humans
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Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641.
Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z. PMID: 34131121; PMCID: PMC8206157.
View in:
PubMed Mentions:
14 Fields:
Translation:
HumansAnimalsCells
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Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants. Kidney360. 2021 May; 2(5):795-808.
Hallows KR, Althouse AD, Li H, Saitta B, Abebe KZ, Bae KT, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 34316721; PMCID: PMC8312696.
View in:
PubMed Mentions:
2 Translation:
HumansCTClinical Trials
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Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial. Kidney360. 2020 Dec 31; 1(12):1363-1372.
Seliger SL, Watnick T, Althouse AD, Perrone RD, Abebe KZ, Hallows KR, Miskulin DC, Bae KT. PMID: 33768205; PMCID: PMC7990324.
View in:
PubMed Mentions:
5 Translation:
HumansCTClinical Trials
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Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease. J Control Release. 2021 01 10; 329:1198-1209.
Wang J, Chin D, Poon C, Mancino V, Pham J, Li H, Ho PY, Hallows KR, Chung EJ. PMID: 33127449; PMCID: PMC7904655.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimals
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AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020 08; 16(8):1550-1552.
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 32597364; PMCID: PMC7469532.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness. FASEB J. 2020 05; 34(5):7036-7057.
Jin K, Ma Y, Manrique-Caballero CL, Li H, Emlet DR, Li S, Baty CJ, Wen X, Kim-Campbell N, Frank A, Menchikova EV, Pastor-Soler NM, Hallows KR, Jackson EK, Shiva S, Pinsky MR, Zuckerbraun BS, Kellum JA, G?mez H. PMID: 32246808.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020 03 05; 77(5):951-969.e9.
Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 31995728; PMCID: PMC7785494.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansAnimalsCells
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AMPK phosphorylation of the �1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1513-F1525.
Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR. PMID: 31566435; PMCID: PMC6962512.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells. Methods Cell Biol. 2019; 153:185-203.
Saitta B, Jalili MF, Zohoorkari H, Rao R, Hallows KR, Baty CJ, Pastor-Soler NM. PMID: 31395379.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury. Am J Kidney Dis. 2019 03; 73(3):429-431.
Unruh M, Wagner B, Hallows KR. PMID: 30241958; PMCID: PMC6389413.
View in:
PubMed Mentions:
4 Fields:
Translation:
Humans
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β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624.
Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. PMID: 29858246; PMCID: PMC6065188.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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"First do no harm": kidney drug targeting to avoid toxicity in ADPKD. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F535-F536.
Chung EJ, Hallows KR. PMID: 29846111.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
-
A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2018; 47(5):352-360.
Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT. PMID: 29779024; PMCID: PMC6010317.
View in:
PubMed Mentions:
22 Fields:
Translation:
HumansCTClinical Trials
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Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383.
Rajani R, Pastor-Soler NM, Hallows KR. PMID: 28614117.
View in:
PubMed Mentions:
25 Fields:
Translation:
HumansAnimalsCells
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Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227.
Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. PMID: 28473772; PMCID: PMC5397526.
View in:
PubMed Mentions:
11
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Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952.
Christensen M, Jensen JB, Jakobsen S, Jessen N, Fr?ki?r J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, N?rregaard R. PMID: 27782167; PMCID: PMC5080611.
View in:
PubMed Mentions:
14 Fields:
Translation:
Animals
-
Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900.
Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. PMID: 27534994; PMCID: PMC5130465.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28.
Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. PMID: 26911844; PMCID: PMC4935778.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansCells
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Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48.
Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. PMID: 26241057; PMCID: PMC4588284.
View in:
PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23.
Jiang C, Veon W, Li H, Hallows KR, Roy P. PMID: 26176334; PMCID: PMC4825560.
View in:
PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28.
Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. PMID: 26136559; PMCID: PMC4556888.
View in:
PubMed Mentions:
30 Fields:
Translation:
Animals
-
Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62.
Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. PMID: 25925251; PMCID: PMC4469889.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9.
Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. PMID: 25253241; PMCID: PMC4269696.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812.
Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. PMID: 25232008; PMCID: PMC4230785.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501.
Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. PMID: 25575158; PMCID: PMC4729166.
View in:
PubMed Mentions:
32 Fields:
Translation:
Humans
-
Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9.
Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. PMID: 24378526; PMCID: PMC4071050.
View in:
PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019.
Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. PMID: 24205069; PMCID: PMC3812018.
View in:
PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7.
Singh T, Hallows KR. PMID: 24118090.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct; 123(10):4139-41.
Kleyman TR, Satlin LM, Hallows KR. PMID: 24051382; PMCID: PMC3786722.
View in:
PubMed Mentions:
13 Fields:
Translation:
Animals
-
Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60.
Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. PMID: 23935101; PMCID: PMC3784700.
View in:
PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56.
Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 23863464; PMCID: PMC3798744.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90.
Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. PMID: 23785098; PMCID: PMC3761205.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9.
Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. PMID: 23704302; PMCID: PMC3805068.
View in:
PubMed Mentions:
20 Fields:
Translation:
Humans
-
AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33.
Pastor-Soler NM, Hallows KR. PMID: 22801443.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400.
King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. PMID: 22869372; PMCID: PMC3460441.
View in:
PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40.
Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244; PMCID: PMC3199524.
View in:
PubMed Mentions:
23 Fields:
Translation:
HumansAnimalsCells
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Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33.
Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. PMID: 21677144; PMCID: PMC3174547.
View in:
PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7.
Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. PMID: 21262823; PMCID: PMC3038735.
View in:
PubMed Mentions:
132 Fields:
Translation:
HumansAnimalsCells
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CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88.
Alzamora R, King JD, Hallows KR. PMID: 21594802.
View in:
PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19.
Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. PMID: 20861072; PMCID: PMC3006313.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83.
C?rdenas C, Miller RA, Smith I, Bui T, Molg? J, M?ller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. PMID: 20655468; PMCID: PMC2911450.
View in:
PubMed Mentions:
472 Fields:
Translation:
AnimalsCells
-
SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92.
Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. PMID: 20600102; PMCID: PMC2932762.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimals
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PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85.
Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20525692; PMCID: PMC2915704.
View in:
PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8.
Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
View in:
PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77.
Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. PMID: 20462973; PMCID: PMC2904179.
View in:
PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77.
Hallows KR, Mount PF, Pastor-Soler NM, Power DA. PMID: 20181668; PMCID: PMC2867412.
View in:
PubMed Mentions:
70 Fields:
Translation:
HumansAnimalsCells
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Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9.
Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20147366; PMCID: PMC2867405.
View in:
PubMed Mentions:
49 Fields:
Translation:
Animals
-
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84.
Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. PMID: 19617399; PMCID: PMC2891496.
View in:
PubMed Mentions:
59 Fields:
Translation:
HumansCells
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AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101.
King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. PMID: 19419994; PMCID: PMC2711654.
View in:
PubMed Mentions:
36 Fields:
Translation:
HumansAnimalsCells
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AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81.
Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. PMID: 19211918; PMCID: PMC2670645.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83.
Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. PMID: 19126549; PMCID: PMC2645828.
View in:
PubMed Mentions:
35 Fields:
Translation:
AnimalsCells
-
Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 02; 284(1):150-157.
Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. PMID: 18981174; PMCID: PMC2610498.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54.
Bhalla V, Hallows KR. PMID: 18753254.
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PubMed Mentions:
127 Fields:
Translation:
Humans
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Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94.
Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. PMID: 18160485; PMCID: PMC4303256.
View in:
PubMed Mentions:
56 Fields:
Translation:
AnimalsCells
-
AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69.
Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
View in:
PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41.
Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. PMID: 16361706.
View in:
PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71.
Hallows KR. PMID: 16046906.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 06; 280(18):17608-16.
Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. PMID: 15753079.
View in:
PubMed Mentions:
79 Fields:
Translation:
HumansAnimalsCells
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Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308.
Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK. PMID: 12519745.
View in:
PubMed Mentions:
57 Fields:
Translation:
HumansAnimalsCells
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Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004.
Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK. PMID: 12427743.
View in:
PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
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Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81.
Raghuram V, Hallows KR, Foskett JK. PMID: 11917537.
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1 Fields:
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HumansCells
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Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21.
Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK. PMID: 10862786; PMCID: PMC378514.
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90 Fields:
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HumansAnimalsCells
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The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4.
Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. PMID: 10768609.
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33 Fields:
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Humans
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Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71.
Hallows KR, Law FY, Packman CH, Knauf PA. PMID: 8698841.
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13 Fields:
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HumansCells
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Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72.
Arreola J, Hallows KR, Knauf PA. PMID: 7485447.
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2 Fields:
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HumansCells
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Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66.
Hallows KR, Restrepo D, Knauf PA. PMID: 7943268.
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2 Fields:
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HumansCells
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Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56.
Hallows KR, Knauf PA. PMID: 7943267.
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3 Fields:
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HumansCells
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Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309.
Hallows KR, Frank RS. PMID: 1298447.
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4 Fields:
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HumansCells
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Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61.
Hallows KR, Packman CH, Knauf PA. PMID: 1767817.
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18 Fields:
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HumansCells
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Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88.
Leith JT, Hallows KT, Arundel CM, Bliven SF. PMID: 3375444.
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1 Fields:
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HumansCells
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Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8.
Hallows KR, Bliven SF, Leith JT. PMID: 3340722.
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HumansCells