Kenneth Raymond Hallows, MD, PhD

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
AddressMMR 628 1333 San Pablo Street
Off Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Director of the USC/UKRO Kidney Research Center

    Title(s)Chief, Division of Nephrology


    Collapse Biography 
    Collapse Education and Training
    Brown University, Providence, RISc.B.05/1987Biophysics
    University of Rochester, Rochester, NYPh.D.10/1993Biophysics
    University of Rochester, Rochester, NYM.D.05/1995Medicine
    University of Pennsylvania, Philadelphia, PA06/1997Internal Medicine
    University of Pennsylvania, Philadelphia, PA06/2001Nephrology and Postdoctoral Fellowship
    Collapse Awards and Honors
    Brown University1983  - 1987CBS Merit Scholarship
    Brown University1987Susan Colver Rosenberger Prize in Biology
    University of Rochester1988Edward F. Adolph Prize in Physiology
    University of Rochester1988Walle J.H. Nauta Award in Neural Sciences
    University of Rochester 1992William F. Neuman Award in Biophysics
    Alpha Omega Alpha1994National Medical Honor Society
    National Kidney Foundation1999Renal Fellow Research Forum Prize
    University of Pennsylvania1999  - 2000J. Russell Elkinton Renal Fellow Teaching Award
    American Society of Nephrology2004Fellow
    American Society of Nephrology2006Carl W. Gottschalk Research Scholar Grantee
    American Physiological Society2009Lazaro J. Mandel Young Investigator Award

    Collapse Overview 
    Collapse Overview
    Dr. Hallows is studying the metabolic control of kidney epithelial salt and water transport mechanisms with relevance to hypertension, acute kidney injury and chronic kidney disease. He is also studying the role of metabolic changes in autosomal dominant polycystic kidney disease and other kidney diseases at various levels.

    After completing his undergraduate training at Brown University, Dr. Hallows earned his PhD and MD degrees from the University of Rochester. He then went on to complete residency in internal medicine and then a fellowship in nephrology at the Hospital of the University of Pennsylvania. After spending a year as an instructor at the University of Pennsylvania, Dr. Hallows moved to the University of Pittsburgh as an assistant professor, then associate professor of medicine, before moving to the Keck School of Medicine of USC in 2015.

    Collapse Research 
    Collapse Research Activities and Funding
    2017 Western Epithelial Biology Society (WEBS) meeting
    NIH R13DK113785Mar 1, 2017 - Feb 28, 2018
    Role: Principal Investigator
    Mechanisms of ENaC Regulation by AMP-activated Kinase
    NIH R03DK068390Jul 1, 2004 - Jun 30, 2006
    Role: Principal Investigator
    MECHANISM OF INHIBITION OF CFTR BY AMP-ACTIVATED KINASE
    NIH K08DK059477Jul 1, 2001 - Jun 30, 2006
    Role: Principal Investigator
    NOVEL INTERACTION OF AMP-KINASE WITH CFTR C1 CHANNEL
    NIH F32DK009994Sep 21, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In vitro delivery of mTOR inhibitors by kidney-targeted micelles for autosomal dominant polycystic kidney disease. SLAS Technol. 2023 Feb 19. Cox A, Tung M, Li H, Hallows KR, Chung EJ. PMID: 36804177.
      View in: PubMed   Mentions:    Fields:    
    2. Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice. Front Mol Biosci. 2022; 9:1001941. Hallows KR, Li H, Saitta B, Sepehr S, Huang P, Pham J, Wang J, Mancino V, Chung EJ, Pinkosky SL, Pastor-Soler NM. PMID: 36504724; PMCID: PMC9730828.
      View in: PubMed   Mentions: 1  
    3. Effects of Hydrochlorothiazide and Metformin on Aquaresis and Nephroprotection by a Vasopressin V2 Receptor Antagonist in ADPKD: A Randomized Crossover Trial. Clin J Am Soc Nephrol. 2022 04; 17(4):507-517. Kramers BJ, Koorevaar IW, van Gastel MDA, van Goor H, Hallows KR, Heerspink HL, Li H, Leonhard WN, Peters DJM, Qiu J, Touw DJ, Gansevoort RT, Meijer E. PMID: 35314480; PMCID: PMC8993480.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    4. Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. Am J Physiol Renal Physiol. 2022 01 01; 322(1):F27-F41. Pastor-Soler NM, Li H, Pham J, Rivera D, Ho PY, Mancino V, Saitta B, Hallows KR. PMID: 34806449.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    5. Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD). Kidney Int. 2021 09; 100(3):684-696. Perrone RD, Abebe KZ, Watnick TJ, Althouse AD, Hallows KR, Lalama CM, Miskulin DC, Seliger SL, Tao C, Harris PC, Bae KT. PMID: 34186056; PMCID: PMC8801184.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    6. Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors. Nat Commun. 2021 06 15; 12(1):3641. Zeng Z, Huang B, Parvez RK, Li Y, Chen J, Vonk AC, Thornton ME, Patel T, Rutledge EA, Kim AD, Yu J, Grubbs BH, McMahon JA, Pastor-Soler NM, Hallows KR, McMahon AP, Li Z. PMID: 34131121; PMCID: PMC8206157.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. Association of Baseline Urinary Metabolic Biomarkers with ADPKD Severity in TAME-PKD Clinical Trial Participants. Kidney360. 2021 May; 2(5):795-808. Hallows KR, Althouse AD, Li H, Saitta B, Abebe KZ, Bae KT, Miskulin DC, Perrone RD, Seliger SL, Watnick TJ. PMID: 34316721; PMCID: PMC8312696.
      View in: PubMed   Mentions: 2  Translation:HumansCTClinical Trials
    8. Baseline Characteristics and Patient-Reported Outcomes of ADPKD Patients in the Multicenter TAME-PKD Clinical Trial. Kidney360. 2020 Dec 31; 1(12):1363-1372. Seliger SL, Watnick T, Althouse AD, Perrone RD, Abebe KZ, Hallows KR, Miskulin DC, Bae KT. PMID: 33768205; PMCID: PMC7990324.
      View in: PubMed   Mentions: 5  Translation:HumansCTClinical Trials
    9. Oral delivery of metformin by chitosan nanoparticles for polycystic kidney disease. J Control Release. 2021 01 10; 329:1198-1209. Wang J, Chin D, Poon C, Mancino V, Pham J, Li H, Ho PY, Hallows KR, Chung EJ. PMID: 33127449; PMCID: PMC7904655.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    10. AMPK is activated during lysosomal damage via a galectin-ubiquitin signal transduction system. Autophagy. 2020 08; 16(8):1550-1552. Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 32597364; PMCID: PMC7469532.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    11. Activation of AMP-activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness. FASEB J. 2020 05; 34(5):7036-7057. Jin K, Ma Y, Manrique-Caballero CL, Li H, Emlet DR, Li S, Baty CJ, Wen X, Kim-Campbell N, Frank A, Menchikova EV, Pastor-Soler NM, Hallows KR, Jackson EK, Shiva S, Pinsky MR, Zuckerbraun BS, Kellum JA, G?mez H. PMID: 32246808.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    12. AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System. Mol Cell. 2020 03 05; 77(5):951-969.e9. Jia J, Bissa B, Brecht L, Allers L, Choi SW, Gu Y, Zbinden M, Burge MR, Timmins G, Hallows K, Behrends C, Deretic V. PMID: 31995728; PMCID: PMC7785494.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansAnimalsCells
    13. AMPK phosphorylation of the �1Pix exchange factor regulates the assembly and function of an ENaC inhibitory complex in kidney epithelial cells. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1513-F1525. Ho PY, Li H, Cheng L, Bhalla V, Fenton RA, Hallows KR. PMID: 31566435; PMCID: PMC6962512.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    14. Ex vivo kidney slice preparations as a model system to study signaling cascades in kidney epithelial cells. Methods Cell Biol. 2019; 153:185-203. Saitta B, Jalili MF, Zohoorkari H, Rao R, Hallows KR, Baty CJ, Pastor-Soler NM. PMID: 31395379.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    15. MIF Matters: The Macrophage Migration Inhibitory Factor and Kidney Injury. Am J Kidney Dis. 2019 03; 73(3):429-431. Unruh M, Wagner B, Hallows KR. PMID: 30241958; PMCID: PMC6389413.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    16. β1Pix exchange factor stabilizes the ubiquitin ligase Nedd4-2 and plays a critical role in ENaC regulation by AMPK in kidney epithelial cells. J Biol Chem. 2018 07 20; 293(29):11612-11624. Ho PY, Li H, Pavlov TS, Tuerk RD, Tabares D, Brunisholz R, Neumann D, Staruschenko A, Hallows KR. PMID: 29858246; PMCID: PMC6065188.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. "First do no harm": kidney drug targeting to avoid toxicity in ADPKD. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F535-F536. Chung EJ, Hallows KR. PMID: 29846111.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    18. A Randomized Clinical Trial of Metformin to Treat Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2018; 47(5):352-360. Seliger SL, Abebe KZ, Hallows KR, Miskulin DC, Perrone RD, Watnick T, Bae KT. PMID: 29779024; PMCID: PMC6010317.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCTClinical Trials
    19. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383. Rajani R, Pastor-Soler NM, Hallows KR. PMID: 28614117.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    20. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. PMID: 28473772; PMCID: PMC5397526.
      View in: PubMed   Mentions: 11  
    21. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952. Christensen M, Jensen JB, Jakobsen S, Jessen N, Fr?ki?r J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, N?rregaard R. PMID: 27782167; PMCID: PMC5080611.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    22. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 11 01; 311(5):F890-F900. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. PMID: 27534994; PMCID: PMC5130465.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    23. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1216-28. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. PMID: 26911844; PMCID: PMC4935778.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. PMID: 26241057; PMCID: PMC4588284.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    25. Epithelial morphological reversion drives Profilin-1-induced elevation of p27(kip1) in mesenchymal triple-negative human breast cancer cells through AMP-activated protein kinase activation. Cell Cycle. 2015; 14(18):2914-23. Jiang C, Veon W, Li H, Hallows KR, Roy P. PMID: 26176334; PMCID: PMC4825560.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. PMID: 26136559; PMCID: PMC4556888.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    27. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. PMID: 25925251; PMCID: PMC4469889.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    28. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1380-9. Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. PMID: 25253241; PMCID: PMC4269696.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    29. A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation. Mol Biol Cell. 2014 Nov 15; 25(23):3798-812. Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G. PMID: 25232008; PMCID: PMC4230785.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    30. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. PMID: 25575158; PMCID: PMC4729166.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    31. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. PMID: 24378526; PMCID: PMC4071050.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    32. Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One. 2013; 8(10):e78019. Weixel KM, Marciszyn A, Alzamora R, Li H, Fischer O, Edinger RS, Hallows KR, Johnson JP. PMID: 24205069; PMCID: PMC3812018.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Hemodialysis for the treatment of severe accidental hypothermia. Semin Dial. 2014 May-Jun; 27(3):295-7. Singh T, Hallows KR. PMID: 24118090.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Opening lines of communication in the distal nephron. J Clin Invest. 2013 Oct; 123(10):4139-41. Kleyman TR, Satlin LM, Hallows KR. PMID: 24051382; PMCID: PMC3786722.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. Noncanonical control of vasopressin receptor type 2 signaling by retromer and arrestin. J Biol Chem. 2013 Sep 27; 288(39):27849-60. Feinstein TN, Yui N, Webber MJ, Wehbi VL, Stevenson HP, King JD, Hallows KR, Brown D, Bouley R, Vilardaga JP. PMID: 23935101; PMCID: PMC3784700.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    36. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 23863464; PMCID: PMC3798744.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    37. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. PMID: 23785098; PMCID: PMC3761205.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    38. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. PMID: 23704302; PMCID: PMC3805068.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    39. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. Pastor-Soler NM, Hallows KR. PMID: 22801443.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    40. Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase. J Biol Chem. 2012 Sep 28; 287(40):33389-400. King JD, Lee J, Riemen CE, Neumann D, Xiong S, Foskett JK, Mehta A, Muimo R, Hallows KR. PMID: 22869372; PMCID: PMC3460441.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    41. Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem. 2011 Oct 28; 286(43):37830-40. Chandran S, Li H, Dong W, Krasinska K, Adams C, Alexandrova L, Chien A, Hallows KR, Bhalla V. PMID: 21900244; PMCID: PMC3199524.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    42. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. PMID: 21677144; PMCID: PMC3174547.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    43. Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2462-7. Takiar V, Nishio S, Seo-Mayer P, King JD, Li H, Zhang L, Karihaloo A, Hallows KR, Somlo S, Caplan MJ. PMID: 21262823; PMCID: PMC3038735.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    44. CFTR regulation by phosphorylation. Methods Mol Biol. 2011; 741:471-88. Alzamora R, King JD, Hallows KR. PMID: 21594802.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    45. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. PMID: 20861072; PMCID: PMC3006313.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    46. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 2010 Jul 23; 142(2):270-83. C?rdenas C, Miller RA, Smith I, Bui T, Molg? J, M?ller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. PMID: 20655468; PMCID: PMC2911450.
      View in: PubMed   Mentions: 472     Fields:    Translation:AnimalsCells
    47. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. PMID: 20600102; PMCID: PMC2932762.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimals
    48. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20525692; PMCID: PMC2915704.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    49. Phosphopeptide screen uncovers novel phosphorylation sites of Nedd4-2 that potentiate its inhibition of the epithelial Na+ channel. J Biol Chem. 2010 Jul 09; 285(28):21671-8. Hallows KR, Bhalla V, Oyster NM, Wijngaarden MA, Lee JK, Li H, Chandran S, Xia X, Huang Z, Chalkley RJ, Burlingame AL, Pearce D. PMID: 20466724; PMCID: PMC2898378.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    50. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. PMID: 20462973; PMCID: PMC2904179.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    51. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. Hallows KR, Mount PF, Pastor-Soler NM, Power DA. PMID: 20181668; PMCID: PMC2867412.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    52. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. PMID: 20147366; PMCID: PMC2867405.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    53. AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol. 2010 Jun; 42(6):676-84. Myerburg MM, King JD, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR. PMID: 19617399; PMCID: PMC2891496.
      View in: PubMed   Mentions: 59     Fields:    Translation:HumansCells
    54. AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR. Am J Physiol Cell Physiol. 2009 Jul; 297(1):C94-101. King JD, Fitch AC, Lee JK, McCane JE, Mak DO, Foskett JK, Hallows KR. PMID: 19419994; PMCID: PMC2711654.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    55. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. PMID: 19211918; PMCID: PMC2670645.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    56. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. PMID: 19126549; PMCID: PMC2645828.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    57. Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2009 Jan 02; 284(1):150-157. Edinger RS, Lebowitz J, Li H, Alzamora R, Wang H, Johnson JP, Hallows KR. PMID: 18981174; PMCID: PMC2610498.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    58. Mechanisms of ENaC regulation and clinical implications. J Am Soc Nephrol. 2008 Oct; 19(10):1845-54. Bhalla V, Hallows KR. PMID: 18753254.
      View in: PubMed   Mentions: 127     Fields:    Translation:Humans
    59. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. PMID: 18160485; PMCID: PMC4303256.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    60. AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2. J Biol Chem. 2006 Sep 08; 281(36):26159-69. Bhalla V, Oyster NM, Fitch AC, Wijngaarden MA, Neumann D, Schlattner U, Pearce D, Hallows KR. PMID: 16844684.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    61. Up-regulation of AMP-activated kinase by dysfunctional cystic fibrosis transmembrane conductance regulator in cystic fibrosis airway epithelial cells mitigates excessive inflammation. J Biol Chem. 2006 Feb 17; 281(7):4231-41. Hallows KR, Fitch AC, Richardson CA, Reynolds PR, Clancy JP, Dagher PC, Witters LA, Kolls JK, Pilewski JM. PMID: 16361706.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    62. Emerging role of AMP-activated protein kinase in coupling membrane transport to cellular metabolism. Curr Opin Nephrol Hypertens. 2005 Sep; 14(5):464-71. Hallows KR. PMID: 16046906.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    63. Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. J Biol Chem. 2005 May 06; 280(18):17608-16. Carattino MD, Edinger RS, Grieser HJ, Wise R, Neumann D, Schlattner U, Johnson JP, Kleyman TR, Hallows KR. PMID: 15753079.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    64. Physiological modulation of CFTR activity by AMP-activated protein kinase in polarized T84 cells. Am J Physiol Cell Physiol. 2003 May; 284(5):C1297-308. Hallows KR, Kobinger GP, Wilson JM, Witters LA, Foskett JK. PMID: 12519745.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    65. Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cells. J Biol Chem. 2003 Jan 10; 278(2):998-1004. Hallows KR, McCane JE, Kemp BE, Witters LA, Foskett JK. PMID: 12427743.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    66. Yeast two-hybrid identification and analysis of protein interactions with CFTR. Methods Mol Med. 2002; 70:365-81. Raghuram V, Hallows KR, Foskett JK. PMID: 11917537.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    67. Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase. J Clin Invest. 2000 Jun; 105(12):1711-21. Hallows KR, Raghuram V, Kemp BE, Witters LA, Foskett JK. PMID: 10862786; PMCID: PMC378514.
      View in: PubMed   Mentions: 90     Fields:    Translation:HumansAnimalsCells
    68. The urine/plasma electrolyte ratio: a predictive guide to water restriction. Am J Med Sci. 2000 Apr; 319(4):240-4. Furst H, Hallows KR, Post J, Chen S, Kotzker W, Goldfarb S, Ziyadeh FN, Neilson EG. PMID: 10768609.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    69. Changes in cytoskeletal actin content, F-actin distribution, and surface morphology during HL-60 cell volume regulation. J Cell Physiol. 1996 Apr; 167(1):60-71. Hallows KR, Law FY, Packman CH, Knauf PA. PMID: 8698841.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    70. Volume-activated chloride channels in HL-60 cells: potent inhibition by an oxonol dye. Am J Physiol. 1995 Oct; 269(4 Pt 1):C1063-72. Arreola J, Hallows KR, Knauf PA. PMID: 7485447.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    71. Control of intracellular pH during regulatory volume decrease in HL-60 cells. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1057-66. Hallows KR, Restrepo D, Knauf PA. PMID: 7943268.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    72. Regulatory volume decrease in HL-60 cells: importance of rapid changes in permeability of Cl- and organic solutes. Am J Physiol. 1994 Oct; 267(4 Pt 1):C1045-56. Hallows KR, Knauf PA. PMID: 7943267.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    73. Changes in mechanical properties with DMSO-induced differentiation of HL-60 cells. Biorheology. 1992 Mar-Jun; 29(2-3):295-309. Hallows KR, Frank RS. PMID: 1298447.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    74. Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells. Am J Physiol. 1991 Dec; 261(6 Pt 1):C1154-61. Hallows KR, Packman CH, Knauf PA. PMID: 1767817.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    75. Changes in X-ray sensitivity and glutathione content of human colon tumor cells after exposure to the differentiation-inducing agent sodium butyrate. Radiat Res. 1988 Jun; 114(3):579-88. Leith JT, Hallows KT, Arundel CM, Bliven SF. PMID: 3375444.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    76. Effects of the differentiating agents sodium butyrate and N-methylformamide on the oxygen enhancement ratio of human colon tumor cells. Radiat Res. 1988 Jan; 113(1):191-8. Hallows KR, Bliven SF, Leith JT. PMID: 3340722.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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