Nuria Maria Pastor-Soler, MD, PhD

TitleAssociate Professor of Medicine
InstitutionUniversity of Southern California
AddressMMR 628 1333 San Pablo St.
Off Campus
Los Angeles CA 90033
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    Other Positions
    TitleAssistant Dean For Research Mentoring

    Collapse Biography 
    Collapse Awards and Honors
    Armand Hammer United World College1984  - 1986Full Scholarship
    1985  - 1986Abigail Van Buren Scholarship
    Bryn Mawr College1986  - 1989Full Scholarship
    Haverford College1988Pew Summer Research Foundation Fellowship
    Dorothy Nepper Marshall Teacher Apprenticeship1988  - 1989Scholar
    Thomas Jefferson University1989  - 1996Gibbon Scholar
    P. and E. Brown Foerderer Foundation1990  - 1991Fellowship
    American Society of Nephrology2005Fellow
    Massachusetts General Hospital2005Claflin Distinguished Scholar Award
    American Society of Nephrology2009Carl W. Gottschalk Research Scholar Grant
    American Physiological Society2009Renal Section, New Investigator Award
    American Physiological Society2011Career Enhancement Award
    American Society for Clinical Investigation2012Member
    Telluride Epithelial Physiology Workshop2012Research Recognition Award
    American Physiological Society2012Renal Section, Young Investigator Award
    Department of Medicine, University of Pittsburgh2012  - 2014Junior Scholar Award
    Council for the Kidney in Cardiovascular Disease, American Heart Association2014  - 2016Elected to Vice-Chair
    Women in Nephrology2016President
    Council for the Kidney in Cardiovascular Disease, American Heart Association2016Chair

    Collapse Overview 
    Collapse Overview
    Dr. Pastor-Soler's research interests include regulation acid-base homeostasis by the kidney and the study of the vacuolar proton ATPase (V-ATPase) in the kidney and the male reproductive tract. Other research projects in her laboratory study the regulation of sodium transport in the collecting duct by bicarbonate-regulated sAC, and renal salt transport regulation by WNK kinases, to name a few. She is currently studying the molecular and cellular mechanisms by which metabolic pathways in the kidney are affected by acidosis, a known predictor of CKD progression. She is also studying renal cell carcinomas with the aim to confirm a novel biomarker that could be used clinically to assess the presence and severity of this disease.

    Dr. Pastor-Soler earned her medical degree from Jefferson Medical College. She then went on to complete her PhD in Biochemistry and Molecular Biology at Jefferson. Dr. Pastor-Soler completed her Nephrology Fellowship at the Brigham and Women's/Massachusetts General Hospital program. She is currently Associate Professor of Medicine in the Division of Nephrology and Hypertension and Assistant Dean for Research Mentoring at Keck School of Medicine of USC. She is also the Director of the Required Scholarly Project Program.

    Collapse Research 
    Collapse Research Activities and Funding
    Epithelial Transport Group Sessions at the Experimental Biology (FASEB)meeting 2
    NIH/NIDDK R13DK098965Apr 1, 2013 - Mar 31, 2014
    Role: Principal Investigator
    Epithelial Transport Group Meeting at the American Physiological Society Meeting
    NIH/NIDDK R13DK092095Apr 18, 2011 - Apr 17, 2012
    Role: Principal Investigator
    Mechanisms of Kinase-dependent Regulation of the V-ATPase in Kidney
    NIH/NIDDK R01DK084184Sep 1, 2009 - Aug 31, 2014
    Role: Principal Investigator
    Women in Nephrology Professional Development Seminar
    NIH/NIDDK R13DK077550Sep 30, 2006 - Aug 31, 2007
    Role: Principal Investigator
    Regulation of Epididymal Luminal Acidification
    NIH/NICHD K08HD045524Jul 1, 2004 - Dec 30, 2009
    Role: Principal Investigator
    NIH/NICHD F32HD008684Mar 4, 2001
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Rao R, Omi K, Rajani R, Li H, Pastor-Soler NM. Using Ex Vivo Kidney Slices to Study AMPK Effects on Kidney Proteins. Methods Mol Biol. 2018; 1732:449-464. PMID: 29480492.
      View in: PubMed
    2. Rajani R, Pastor-Soler NM, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 09; 26(5):375-383. PMID: 28614117.
      View in: PubMed
    3. Veiras LC, Girardi ACC, Curry J, Pei L, Ralph DL, Tran A, Castelo-Branco RC, Pastor-Soler N, Arranz CT, Yu ASL, McDonough AA. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017 Dec; 28(12):3504-3517. PMID: 28774999.
      View in: PubMed
    4. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler NM, Hallows KR, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. PMID: 28473772.
      View in: PubMed
    5. Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries WH, Morrisroe S, Volpe JK, Kellum JA. Insulin-like growth factor binding protein 7 and tissue inhibitor of metalloproteinases-2: differential expression and secretion in human kidney tubule cells. Am J Physiol Renal Physiol. 2017 Feb 01; 312(2):F284-F296. PMID: 28003188.
      View in: PubMed
    6. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler NM, Hallows KR, Nørregaard R. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 10 26; 6:35952. PMID: 27782167.
      View in: PubMed
    7. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler NM, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 01; 311(5):F890-F900. PMID: 27534994.
      View in: PubMed
    8. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler NM. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 01; 310(11):F1216-28. PMID: 26911844; PMCID: PMC4935778 [Available on 06/01/17].
    9. Al-Bataineh MM, Kinlough CL, Poland PA, Pastor-Soler NM, Sutton TA, Mang HE, Bastacky SI, Gendler SJ, Madsen CS, Singh S, Monga SP, Hughey RP. Muc1 enhances the ß-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F569-79. PMID: 26739894; PMCID: PMC4796271 [Available on 03/15/17].
    10. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler NM, Hallows KR, Staub O, Subramanya AR. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep; 125(9):3433-48. PMID: 26241057; PMCID: PMC4588284.
    11. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 01; 309(5):F414-28. PMID: 26136559; PMCID: PMC4556888.
    12. Pastor-Soler NM, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. PMID: 25925251; PMCID: PMC4469889.
    13. Roy A, Al-bataineh MM, Pastor-Soler NM. Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol. 2015 Feb 06; 10(2):305-24. PMID: 25632105; PMCID: PMC4317747.
    14. Morrell ED, Kellum JA, Pastor-Soler NM, Hallows KR. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014 Sep 02; 18(5):501. PMID: 25575158; PMCID: PMC4729166.
    15. Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep; 10(9):707-9. PMID: 25064832; PMCID: PMC4138287.
    16. Raghavan V, Rbaibi Y, Pastor-Soler NM, Carattino MD, Weisz OA. Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8506-11. PMID: 24912170; PMCID: PMC4060694.
    17. Al-bataineh MM, Gong F, Marciszyn AL, Myerburg MM, Pastor-Soler NM. Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F981-95. PMID: 24553431; PMCID: PMC4010682.
    18. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler NM. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. PMID: 24378526; PMCID: PMC4071050.
    19. Paunescu TG, Lu HA, Russo LM, Pastor-Soler NM, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1783-95. PMID: 24133120; PMCID: PMC3882446.
    20. Wang Z, Subramanya AR, Satlin LM, Pastor-Soler NM, Carattino MD, Kleyman TR. Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol. 2013 Oct 15; 305(8):C846-53. PMID: 23885063; PMCID: PMC3798677.
    21. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler NM. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 01; 305(7):F943-56. PMID: 23863464; PMCID: PMC3798744.
    22. Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 01; 305(5):F679-90. PMID: 23785098; PMCID: PMC3761205.
    23. Singh T, Maw TT, Henry BL, Pastor-Soler NM, Unruh ML, Hallows KR, Nolin TD. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. PMID: 23704302; PMCID: PMC3805068.
    24. Szalinski CM, Guerriero CJ, Ruiz WG, Docter BE, Rbaibi Y, Pastor-Soler NM, Apodaca G, Puthenveedu MA, Weisz OA. PIP5KIß selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One. 2013; 8(1):e53790. PMID: 23342003; PMCID: PMC3547069.
    25. Pastor-Soler NM, Hallows KR. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. PMID: 22801443.
      View in: PubMed
    26. Mo D, Costa SA, Ihrke G, Youker RT, Pastor-Soler N, Hughey RP, Weisz OA. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012 Sep; 23(18):3636-46. PMID: 22855528.
      View in: PubMed
    27. Liu W, Pastor-Soler NM, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F205-15. PMID: 21957178; PMCID: PMC3251342.
    28. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler NM, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. PMID: 21677144; PMCID: PMC3174547.
    29. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler NM, Hallows KR. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. PMID: 20861072; PMCID: PMC3006313.
    30. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler NM, Hallows KR, McGaffin KR, Ahmad F. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. PMID: 20600102; PMCID: PMC2932762.
    31. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler NM. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 06; 285(32):24676-85. PMID: 20525692.
      View in: PubMed
    32. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. PMID: 20462973; PMCID: PMC2904179.
    33. Hallows KR, Mount PF, Pastor-Soler NM, Power DA. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. PMID: 20181668.
      View in: PubMed
    34. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler NM. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. PMID: 20147366.
      View in: PubMed
    35. Pastor-Soler NM, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S. Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21. PMID: 19948840; PMCID: PMC3773695.
    36. Banerjee SK, McGaffin KR, Pastor-Soler NM, Ahmad F. SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovasc Res. 2009 Oct 01; 84(1):111-8. PMID: 19509029; PMCID: PMC2741348.
    37. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler NM. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. PMID: 19211918; PMCID: PMC2670645.
    38. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. PMID: 19126549; PMCID: PMC2645828.
    39. Estilo G, Liu W, Pastor-Soler N, Mitchell P, Carattino MD, Kleyman TR, Satlin LM. Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F780-8. PMID: 18579708; PMCID: PMC2536880.
    40. Pastor-Soler NM, Hallows KR, Smolak C, Gong F, Brown D, Breton S. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. PMID: 18160485; PMCID: PMC4303256.
    41. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 01; 283(5):2986-96. PMID: 18055461.
      View in: PubMed
    42. Pastor-Soler N, Piétrement C, Breton S. Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. PMID: 16287991.
      View in: PubMed
    43. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. PMID: 15644488.
      View in: PubMed
    44. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 04; 280(9):8452-63. PMID: 15591047.
      View in: PubMed
    45. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. PMID: 15149973.
      View in: PubMed
    46. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 05; 278(49):49523-9. PMID: 14512417; PMCID: PMC3652382.
    47. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. PMID: 12374804.
      View in: PubMed
    48. Fisher JS, Pastor-Soler N, Sharpe RM, Breton S. Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. PMID: 12297525.
      View in: PubMed
    49. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. PMID: 12021052.
      View in: PubMed
    50. Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D. Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93. PMID: 11466204.
      View in: PubMed
    51. Pastor-Soler NM, Schertz EM, Rafi MA, de Gala G, Wenger DA. Metachromatic leukodystrophy among southern Alaskan Eskimos: molecular and genetic studies. J Inherit Metab Dis. 1995; 18(3):326-32. PMID: 7474900.
      View in: PubMed
    52. Pastor-Soler NM, Rafi MA, Hoffman JD, Hu D, Wenger DA. Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene. Hum Mutat. 1994; 4(3):199-207. PMID: 7833949.
      View in: PubMed