Loading...
Sign in to edit your profile (add interests, mentoring, photo, etc.)

    Nuria Maria Pastor-Soler, MD, PhD

    TitleAssociate Professor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressIRD 2020 Zonal Ave
    Off Campus
    Los Angeles California 90033
    vCardDownload vCard
      Other Positions
      TitleAssistant Dean For Research Mentoring


      Collapse Overview 
      Collapse Overview
      Dr. Pastor-Soler's research interests include regulation acid-base homeostasis by the kidney and the study of the vacuolar proton ATPase (V-ATPase) in the kidney and the male reproductive tract. Other research projects in her laboratory study the regulation of sodium transport in the collecting duct by bicarbonate-regulated sAC, and renal salt transport regulation by WNK kinases, to name a few. She is currently studying the molecular and cellular mechanisms by which metabolic pathways in the kidney are affected by acidosis, a known predictor of CKD progression. She is also studying renal cell carcinomas with the aim to confirm a novel biomarker that could be used clinically to assess the presence and severity of this disease.

      Dr. Pastor-Soler earned her medical degree from Jefferson Medical College. She then went on to complete her PhD in Biochemistry and Molecular Biology at Jefferson. Dr. Pastor-Soler completed her Nephrology Fellowship at the Brigham and Women's/Massachusetts General Hospital program. She is currently Associate Professor of Medicine in the Division of Nephrology and Hypertension and Assistant Dean for Research Mentoring at Keck School of Medicine of USC. She is also the Director of the Required Scholarly Project Program.


      Collapse Biography 
      Collapse Awards and Honors
      Armand Hammer United World College1984  - 1986Full Scholarship
      1985  - 1986Abigail Van Buren Scholarship
      Bryn Mawr College1986  - 1989Full Scholarship
      Haverford College1988Pew Summer Research Foundation Fellowship
      Dorothy Nepper Marshall Teacher Apprenticeship1988  - 1989Scholar
      Thomas Jefferson University1989  - 1996Gibbon Scholar
      P. and E. Brown Foerderer Foundation1990  - 1991Fellowship
      American Society of Nephrology2005Fellow
      Massachusetts General Hospital2005Claflin Distinguished Scholar Award
      American Society of Nephrology2009Carl W. Gottschalk Research Scholar Grant
      American Physiological Society2009Renal Section, New Investigator Award
      American Physiological Society2011Career Enhancement Award
      American Society for Clinical Investigation2012Member
      Telluride Epithelial Physiology Workshop2012Research Recognition Award
      American Physiological Society2012Renal Section, Young Investigator Award
      Department of Medicine, University of Pittsburgh2012  - 2014Junior Scholar Award
      Council for the Kidney in Cardiovascular Disease, American Heart Association2014  - 2016Elected to Vice-Chair
      Women in Nephrology2016President
      Council for the Kidney in Cardiovascular Disease, American Heart Association2016Chair

      Collapse ORNG Applications 
      Collapse Required Scholarly Project Mentor

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Rajani R, Pastor-Soler N, Hallows KR. Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease. Curr Opin Nephrol Hypertens. 2017 Jun 12. PMID: 28614117.
        View in: PubMed
      2. Pavlov TS, Levchenko V, Ilatovskaya DV, Li H, Palygin O, Pastor-Soler N, Hallows KR, Staruschenko A. Lack of Effects of Metformin and AICAR Chronic Infusion on the Development of Hypertension in Dahl Salt-Sensitive Rats. Front Physiol. 2017; 8:227. PMID: 28473772.
        View in: PubMed
      3. Emlet DR, Pastor-Soler N, Marciszyn A, Wen X, Gomez H, Humphries WH, Morrisroe S, Volpe JK, Kellum JA. Insulin-Like Growth Factor Binding Protein 7 and Tissue Inhibitor of Metalloproteinases-2: Differential Expression and Secretion in Human Kidney Tubule Cells. Am J Physiol Renal Physiol. 2016 Dec 21; ajprenal.00271.2016. PMID: 28003188.
        View in: PubMed
      4. Christensen M, Jensen JB, Jakobsen S, Jessen N, Frøkiær J, Kemp BE, Marciszyn AL, Li H, Pastor-Soler N, Hallows KR, Nørregaard R. Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 &2 and AMP-activated Protein Kinase in the Kidney. Sci Rep. 2016 Oct 26; 6:35952. PMID: 27782167.
        View in: PubMed
      5. Al-Bataineh MM, Li H, Ohmi K, Gong F, Marciszyn AL, Naveed S, Zhu X, Neumann D, Wu Q, Cheng L, Fenton RA, Pastor-Soler N, Hallows KR. Activation of the metabolic sensor AMP-activated protein kinase inhibits aquaporin-2 function in kidney principal cells. Am J Physiol Renal Physiol. 2016 Nov 01; 311(5):F890-F900. PMID: 27534994.
        View in: PubMed
      6. Al-Bataineh MM, Alzamora R, Ohmi K, Ho PY, Marciszyn AL, Gong F, Li H, Hallows KR, Pastor-Soler N. Aurora kinase A activates the vacuolar H+-ATPase (V-ATPase) in kidney carcinoma cells. Am J Physiol Renal Physiol. 2016 Jun 1; 310(11):F1216-28. PMID: 26911844.
        View in: PubMed
      7. Al-Bataineh MM, Kinlough CL, Poland PA, Pastor-Soler N, Sutton TA, Mang HE, Bastacky SI, Gendler SJ, Madsen CS, Singh S, Monga SP, Hughey RP. Muc1 enhances the β-catenin protective pathway during ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F569-79. PMID: 26739894; PMCID: PMC4796271 [Available on 03/15/17].
      8. Roy A, Al-Qusairi L, Donnelly BF, Ronzaud C, Marciszyn AL, Gong F, Chang YP, Butterworth MB, Pastor-Soler N, Hallows KR, Staub O, Subramanya AR. Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest. 2015 Sep 1; 125(9):3433-48. PMID: 26241057.
        View in: PubMed
      9. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler N, Hallows KR, Singh P. Interactions between HIF-1a and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Am J Physiol Renal Physiol. 2015 Sep 1; 309(5):F414-28. PMID: 26136559.
        View in: PubMed
      10. Pastor-Soler N, Sutton TA, Mang HE, Kinlough CL, Gendler SJ, Madsen CS, Bastacky SI, Ho J, Al-Bataineh MM, Hallows KR, Singh S, Monga SP, Kobayashi H, Haase VH, Hughey RP. Muc1 is protective during kidney ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2015 Jun 15; 308(12):F1452-62. PMID: 25925251.
        View in: PubMed
      11. Roy A, Al-bataineh MM, Pastor-Soler N. Collecting duct intercalated cell function and regulation. Clin J Am Soc Nephrol. 2015 Feb 06; 10(2):305-24. PMID: 25632105; PMCID: PMC4317747.
      12. Morrell ED, Kellum JA, Pastor-Soler N, Hallows KR. Septic acute kidney injury: molecular mechanisms and the importance of stratification and targeting therapy. Crit Care. 2014; 18(5):501. PMID: 25575158.
        View in: PubMed
      13. Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler N, Gardella TJ, Vilardaga JP. Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014 Sep; 10(9):707-9. PMID: 25064832; PMCID: PMC4138287.
      14. Raghavan V, Rbaibi Y, Pastor-Soler N, Carattino MD, Weisz OA. Shear stress-dependent regulation of apical endocytosis in renal proximal tubule cells mediated by primary cilia. Proc Natl Acad Sci U S A. 2014 Jun 10; 111(23):8506-11. PMID: 24912170; PMCID: PMC4060694.
      15. Al-bataineh MM, Gong F, Marciszyn AL, Myerburg MM, Pastor-Soler N. Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F981-95. PMID: 24553431; PMCID: PMC4010682.
      16. Morrell ED, Kellum JA, Hallows KR, Pastor-Soler N. Epithelial transport during septic acute kidney injury. Nephrol Dial Transplant. 2014 Jul; 29(7):1312-9. PMID: 24378526.
        View in: PubMed
      17. Păunescu TG, Lu HA, Russo LM, Pastor-Soler N, McKee M, McLaughlin MM, Bartlett BE, Breton S, Brown D. Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells. Am J Physiol Renal Physiol. 2013 Dec 15; 305(12):F1783-95. PMID: 24133120; PMCID: PMC3882446.
      18. Wang Z, Subramanya AR, Satlin LM, Pastor-Soler N, Carattino MD, Kleyman TR. Regulation of large-conductance Ca2+-activated K+ channels by WNK4 kinase. Am J Physiol Cell Physiol. 2013 Oct 15; 305(8):C846-53. PMID: 23885063; PMCID: PMC3798677.
      19. Alzamora R, Al-Bataineh MM, Liu W, Gong F, Li H, Thali RF, Joho-Auchli Y, Brunisholz RA, Satlin LM, Neumann D, Hallows KR, Pastor-Soler N. AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol. 2013 Oct 1; 305(7):F943-56. PMID: 23863464.
        View in: PubMed
      20. Fraser SA, Choy SW, Pastor-Soler N, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA. AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1. Am J Physiol Renal Physiol. 2013 Sep 1; 305(5):F679-90. PMID: 23785098.
        View in: PubMed
      21. Singh T, Maw TT, Henry BL, Pastor-Soler N, Unruh ML, Hallows KR, Nolin TD. Extracorporeal therapy for dabigatran removal in the treatment of acute bleeding: a single center experience. Clin J Am Soc Nephrol. 2013 Sep; 8(9):1533-9. PMID: 23704302.
        View in: PubMed
      22. Szalinski CM, Guerriero CJ, Ruiz WG, Docter BE, Rbaibi Y, Pastor-Soler N, Apodaca G, Puthenveedu MA, Weisz OA. PIP5KIβ selectively modulates apical endocytosis in polarized renal epithelial cells. PLoS One. 2013; 8(1):e53790. PMID: 23342003; PMCID: PMC3547069.
      23. Pastor-Soler N, Hallows KR. AMP-activated protein kinase regulation of kidney tubular transport. Curr Opin Nephrol Hypertens. 2012 Sep; 21(5):523-33. PMID: 22801443.
        View in: PubMed
      24. Mo D, Costa SA, Ihrke G, Youker RT, Pastor-Soler N, Hughey RP, Weisz OA. Sialylation of N-linked glycans mediates apical delivery of endolyn in MDCK cells via a galectin-9-dependent mechanism. Mol Biol Cell. 2012 Sep; 23(18):3636-46. PMID: 22855528.
        View in: PubMed
      25. Liu W, Pastor-Soler N, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). Am J Physiol Renal Physiol. 2012 Jan 01; 302(1):F205-15. PMID: 21957178; PMCID: PMC3251342.
      26. Rondanino C, Poland PA, Kinlough CL, Li H, Rbaibi Y, Myerburg MM, Al-bataineh MM, Kashlan OB, Pastor-Soler N, Hallows KR, Weisz OA, Apodaca G, Hughey RP. Galectin-7 modulates the length of the primary cilia and wound repair in polarized kidney epithelial cells. Am J Physiol Renal Physiol. 2011 Sep; 301(3):F622-33. PMID: 21677144.
        View in: PubMed
      27. Alzamora R, Gong F, Rondanino C, Lee JK, Smolak C, Pastor-Soler N, Hallows KR. AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. Am J Physiol Renal Physiol. 2010 Dec; 299(6):F1308-19. PMID: 20861072.
        View in: PubMed
      28. Banerjee SK, Wang DW, Alzamora R, Huang XN, Pastor-Soler N, Hallows KR, McGaffin KR, Ahmad F. SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol. 2010 Oct; 49(4):683-92. PMID: 20600102.
        View in: PubMed
      29. Alzamora R, Thali RF, Gong F, Smolak C, Li H, Baty CJ, Bertrand CA, Auchli Y, Brunisholz RA, Neumann D, Hallows KR, Pastor-Soler N. PKA regulates vacuolar H+-ATPase localization and activity via direct phosphorylation of the a subunit in kidney cells. J Biol Chem. 2010 Aug 6; 285(32):24676-85. PMID: 20525692.
        View in: PubMed
      30. Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler N, Neumann D, Hallows KR. Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F167-77. PMID: 20462973.
        View in: PubMed
      31. Hallows KR, Mount PF, Pastor-Soler N, Power DA. Role of the energy sensor AMP-activated protein kinase in renal physiology and disease. Am J Physiol Renal Physiol. 2010 May; 298(5):F1067-77. PMID: 20181668.
        View in: PubMed
      32. Gong F, Alzamora R, Smolak C, Li H, Naveed S, Neumann D, Hallows KR, Pastor-Soler N. Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol. 2010 May; 298(5):F1162-9. PMID: 20147366.
        View in: PubMed
      33. Pastor-Soler N, Fisher JS, Sharpe R, Hill E, Van Hoek A, Brown D, Breton S. Aquaporin 9 expression in the developing rat epididymis is modulated by steroid hormones. Reproduction. 2010 Mar; 139(3):613-21. PMID: 19948840; PMCID: PMC3773695.
      34. Banerjee SK, McGaffin KR, Pastor-Soler N, Ahmad F. SGLT1 is a novel cardiac glucose transporter that is perturbed in disease states. Cardiovasc Res. 2009 Oct 01; 84(1):111-8. PMID: 19509029; PMCID: PMC2741348.
      35. Hallows KR, Alzamora R, Li H, Gong F, Smolak C, Neumann D, Pastor-Soler N. AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C672-81. PMID: 19211918.
        View in: PubMed
      36. Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler N. Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem. 2009 Feb 27; 284(9):5774-83. PMID: 19126549.
        View in: PubMed
      37. Estilo G, Liu W, Pastor-Soler N, Mitchell P, Carattino MD, Kleyman TR, Satlin LM. Effect of aldosterone on BK channel expression in mammalian cortical collecting duct. Am J Physiol Renal Physiol. 2008 Sep; 295(3):F780-8. PMID: 18579708.
        View in: PubMed
      38. Pastor-Soler N, Hallows KR, Smolak C, Gong F, Brown D, Breton S. Alkaline pH- and cAMP-induced V-ATPase membrane accumulation is mediated by protein kinase A in epididymal clear cells. Am J Physiol Cell Physiol. 2008 Feb; 294(2):C488-94. PMID: 18160485.
        View in: PubMed
      39. Pietrement C, Da Silva N, Silberstein C, James M, Marsolais M, Van Hoek A, Brown D, Pastor-Soler N, Ameen N, Laprade R, Ramesh V, Breton S. Role of NHERF1, cystic fibrosis transmembrane conductance regulator, and cAMP in the regulation of aquaporin 9. J Biol Chem. 2008 Feb 1; 283(5):2986-96. PMID: 18055461.
        View in: PubMed
      40. Pastor-Soler N, Piétrement C, Breton S. Role of acid/base transporters in the male reproductive tract and potential consequences of their malfunction. Physiology (Bethesda). 2005 Dec; 20:417-28. PMID: 16287991.
        View in: PubMed
      41. Bouley R, Pastor-Soler N, Cohen O, McLaughlin M, Breton S, Brown D. Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra). Am J Physiol Renal Physiol. 2005 Jun; 288(6):F1103-12. PMID: 15644488.
        View in: PubMed
      42. Beaulieu V, Da Silva N, Pastor-Soler N, Brown CR, Smith PJ, Brown D, Breton S. Modulation of the actin cytoskeleton via gelsolin regulates vacuolar H+-ATPase recycling. J Biol Chem. 2005 Mar 4; 280(9):8452-63. PMID: 15591047.
        View in: PubMed
      43. Silberstein C, Bouley R, Huang Y, Fang P, Pastor-Soler N, Brown D, Van Hoek AN. Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F501-11. PMID: 15149973.
        View in: PubMed
      44. Pastor-Soler N, Beaulieu V, Litvin TN, Da Silva N, Chen Y, Brown D, Buck J, Levin LR, Breton S. Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling. J Biol Chem. 2003 Dec 5; 278(49):49523-9. PMID: 14512417.
        View in: PubMed
      45. van Balkom BW, van Raak M, Breton S, Pastor-Soler N, Bouley R, van der Sluijs P, Brown D, Deen PM. Hypertonicity is involved in redirecting the aquaporin-2 water channel into the basolateral, instead of the apical, plasma membrane of renal epithelial cells. J Biol Chem. 2003 Jan 10; 278(2):1101-7. PMID: 12374804.
        View in: PubMed
      46. Fisher JS, Pastor-Soler N, Sharpe RM, Breton S. Modulation of the onset of postnatal development of H(+)-ATPase-rich cells by steroid hormones in rat epididymis. Biol Reprod. 2002 Oct; 67(4):1106-14. PMID: 12297525.
        View in: PubMed
      47. Pastor-Soler N, Isnard-Bagnis C, Herak-Kramberger C, Sabolic I, Van Hoek A, Brown D, Breton S. Expression of aquaporin 9 in the adult rat epididymal epithelium is modulated by androgens. Biol Reprod. 2002 Jun; 66(6):1716-22. PMID: 12021052.
        View in: PubMed
      48. Pastor-Soler N, Bagnis C, Sabolic I, Tyszkowski R, McKee M, Van Hoek A, Breton S, Brown D. Aquaporin 9 expression along the male reproductive tract. Biol Reprod. 2001 Aug; 65(2):384-93. PMID: 11466204.
        View in: PubMed
      49. Pastor-Soler N, Schertz EM, Rafi MA, de Gala G, Wenger DA. Metachromatic leukodystrophy among southern Alaskan Eskimos: molecular and genetic studies. J Inherit Metab Dis. 1995; 18(3):326-32. PMID: 7474900.
        View in: PubMed
      50. Pastor-Soler N, Rafi MA, Hoffman JD, Hu D, Wenger DA. Metachromatic leukodystrophy in the Navajo Indian population: a splice site mutation in intron 4 of the arylsulfatase A gene. Hum Mutat. 1994; 4(3):199-207. PMID: 7833949.
        View in: PubMed