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Alicia A. McDonough, PhD, FAHA

TitleProfessor of Integrative Anatomical Sciences
InstitutionUniversity of Southern California
DepartmentIntegrative Anatomical Sciences
AddressMMR 508 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1238
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    Collapse Biography 
    Collapse Awards and Honors
    American Physiological Society Epithelial Transport Group2018Steve Hebert Lecturer
    University of Southern California2018Phi Kappa Phi Faculty Recognition Award
    American Society of Nephrology2017Robert W. Schrier Endowed Lectureship
    Medical College of Wisconsin2016J.J. Smith Endowed Lecture
    KCVD Young Investigator Symposium2016Keynote Speaker ASN Kidney Week
    Kansas State Univ. Veterinary Medicine2015Clarenberg Distinguished Lecture
    AHA Kidney in Cardiovascular Disease Council2014Donald Seldin Lecture
    SUNY Buffalo2010Suk Ki Hong Memorial Lecturer
    American Physiological Society2009Ernest H. Starling Distinguished Lectureship
    American Heart Association1984  - 1989Established Investigator Award
    Keck School of Medicine2007  - 2018Outstanding Teaching Awards: '07, '12, '17

    Collapse Research 
    Collapse Research Activities and Funding
    Sodium-chloride co-transporter regulation in the kidney
    NIH/NIDDK R56DK083785Aug 1, 2010 - Jul 31, 2011
    Role: Principal Investigator
    Sodium transporter regulation during hypertension
    NIH/NIDDK R01DK083785Apr 1, 2009 - Mar 31, 2020
    Role: Principal Investigator
    Regulation of Na-CI cotransporter (NCC) subcellular distribution in DCT
    NIH/NHLBI R21HL085388Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    EXTRA-RENAL REGULATION OF POTASSIUM HOMEOSTASIS
    NIH/NIDDK R01DK057678May 1, 2001 - Feb 28, 2006
    Role: Principal Investigator
    Regulation of Sodium Transport in the Kidney
    NIH/NIDDK R01DK034316Jul 1, 1984 - Mar 31, 2010
    Role: Principal Investigator
    REGULATION OF SODIUM PUMPS IN THE KIDNEY
    NIH/NIADDK R01AM034316Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF. The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease. J Am Soc Nephrol. 2018 Sep 05. PMID: 30185469.
      View in: PubMed
    2. Li Q, McDonough AA, Layton HE, Layton AT. Functional Implications of Sexual Dimorphism of Transporter Patterns along the Rat Proximal Tubule: Modeling and Analysis. Am J Physiol Renal Physiol. 2018 May 30. PMID: 29846110.
      View in: PubMed
    3. Varasteh Kia M, Barone S, McDonough AA, Zahedi K, Xu J, Soleimani M. Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis. Cell Physiol Biochem. 2018; 45(4):1551-1565. PMID: 29482189.
      View in: PubMed
    4. van Haaster MC, McDonough AA, Gurley SB. Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. PMID: 29045337.
      View in: PubMed
    5. Hyndman KA, Mironova EV, Giani JF, Dugas C, Collins J, McDonough AA, Stockand JD, Pollock JS. Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways. J Am Heart Assoc. 2017 Oct 24; 6(10). PMID: 29066445.
      View in: PubMed
    6. Prieto MC, Reverte V, Mamenko M, Kuczeriszka M, Veiras LC, Rosales CB, McLellan M, Gentile O, Jensen VB, Ichihara A, McDonough AA, Pochynyuk OM, Gonzalez AA. Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice. Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1243-F1253. PMID: 28814438.
      View in: PubMed
    7. Veiras LC, Girardi ACC, Curry J, Pei L, Ralph DL, Tran A, Castelo-Branco RC, Pastor-Soler N, Arranz CT, Yu ASL, McDonough AA. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017 Dec; 28(12):3504-3517. PMID: 28774999.
      View in: PubMed
    8. McDonough AA, Youn JH. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 Mar; 32(2):100-111. PMID: 28202621.
      View in: PubMed
    9. McDonough AA, Veiras LC, Guevara CA, Ralph DL. Cardiovascular benefits associated with higher dietary K+ vs. lower dietary Na+: evidence from population and mechanistic studies. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E348-E356. PMID: 28174181.
      View in: PubMed
    10. Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH. Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. J Am Soc Nephrol. 2017 Jun; 28(6):1826-1837. PMID: 28062568.
      View in: PubMed
    11. Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA. Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity. Kidney Int. 2017 04; 91(4):856-867. PMID: 27988209.
      View in: PubMed
    12. Veiras LC, Han J, Ralph DL, McDonough AA. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension. Hypertension. 2016 10; 68(4):904-12. PMID: 27600183; PMCID: PMC5016236 [Available on 10/01/17].
    13. McDonough AA. ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule. Kidney Int Rep. 2016 Sep; 1(3):166-176. PMID: 27840855.
      View in: PubMed
    14. Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 Jul 01; 126(7):2509-18. PMID: 27214555.
      View in: PubMed
    15. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 07; 68(1):167-74. PMID: 27141060.
      View in: PubMed
    16. Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough AA, Griffiths R, Sparks MA, Jeffs AD, Crowley SD. Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab. 2016 Feb 09; 23(2):360-8. PMID: 26712462; PMCID: PMC4749461 [Available on 02/09/17].
    17. Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough AA, Girardi AC. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. PMID: 26447224.
      View in: PubMed
    18. Nguyen MT, Han J, Ralph DL, Veiras LC, McDonough AA. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015 Sep; 3(9). PMID: 26347505; PMCID: PMC4600373.
    19. Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. PMID: 26246427.
      View in: PubMed
    20. Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA. Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme. Hypertension. 2015 Sep; 66(3):534-42. PMID: 26150439; PMCID: PMC4825680.
    21. McDonough AA, Nguyen MT. Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension. Hypertension. 2015 Sep; 66(3):450-5. PMID: 26101347; PMCID: PMC4943879.
    22. West CA, McDonough AA, Masilamani SM, Verlander JW, Baylis C. Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F63-70. PMID: 25925254; PMCID: PMC4490381.
    23. Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE. The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol. 2015 Apr; 21:73-81. PMID: 25616034; PMCID: PMC4380835.
    24. Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-?-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar; 65(3):569-76. PMID: 25601932; PMCID: PMC4326622.
    25. McDonough AA, Veiras LC, Minas JN, Ralph DL. Considerations when quantitating protein abundance by immunoblot. Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. PMID: 25540176; PMCID: PMC4360027.
    26. Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 01; 2(12). PMID: 25472608; PMCID: PMC4332208.
    27. Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J. Local pH domains regulate NHE3-mediated Na? reabsorption in the renal proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1249-62. PMID: 25298526; PMCID: PMC4254968.
    28. Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014 Sep; 16(9):477. PMID: 25097114; PMCID: PMC4277187.
    29. Patel HH, McDonough AA. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. PMID: 25031018; PMCID: PMC4166741.
    30. Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. PMID: 25012170; PMCID: PMC4243348.
    31. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. PMID: 24598799; PMCID: PMC4010681.
    32. Nguyen MT, Lee DH, Delpire E, McDonough AA. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. PMID: 23720346; PMCID: PMC3891260.
    33. McDonough AA, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. PMID: 23633048; PMCID: PMC3644996.
    34. Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013 May; 123(5):2011-23. PMID: 23619363; PMCID: PMC3638907.
    35. Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na?/H? exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug; 91(8):951-63. PMID: 23508938; PMCID: PMC3730089.
    36. Lee DH, Maunsbach AB, Riquier-Brison AD, Nguyen MT, Fenton RA, Bachmann S, Yu AS, McDonough AA. Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties. Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C147-63. PMID: 23114965; PMCID: PMC3587378.
    37. McDonough AA, Nguyen MT. How does potassium supplementation lower blood pressure? Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1224-5. PMID: 22550158; PMCID: PMC3362178.
    38. Nguyen MT, Yang LE, Fletcher NK, Lee DH, Kocinsky H, Bachmann S, Delpire E, McDonough AA. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron. Am J Physiol Renal Physiol. 2012 Jul 01; 303(1):F92-104. PMID: 22496411; PMCID: PMC3431149.
    39. Avner ED, McDonough AA, Sweeney WE. Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1434-5. PMID: 22403786; PMCID: PMC3362002.
    40. Gurley SB, Riquier-Brison ADM, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 06; 13(4):469-475. PMID: 21459331; PMCID: PMC3070917.
    41. McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R851-61. PMID: 20106993; PMCID: PMC2853398.
    42. Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, McDonough AA. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010 Jan; 298(1):F177-86. PMID: 19864301; PMCID: PMC2806122.
    43. McDonough AA. Motoring down the microvilli. Focus on "PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI". Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1331-2. PMID: 19776391; PMCID: PMC2793055.
    44. Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Müller-Ehmsen J. Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur J Pharmacol. 2009 Nov 10; 622(1-3):7-14. PMID: 19751721; PMCID: PMC4948948.
    45. Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25. PMID: 19414841; PMCID: PMC4944758.
    46. Riquier AD, Lee DH, McDonough AA. Renal NHE3 and NaPi2 partition into distinct membrane domains. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C900-10. PMID: 19158399; PMCID: PMC2670655.
    47. Lee DH, Riquier AD, Yang LE, Leong PK, Maunsbach AB, McDonough AA. Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F810-8. PMID: 19144688; PMCID: PMC2670641.
    48. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. PMID: 18759636; PMCID: PMC4946439.
    49. Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough AA. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1003-16. PMID: 18653479; PMCID: PMC2576159.
    50. Hanner F, Schnichels M, Zheng-Fischhöfer Q, Yang LE, Toma I, Willecke K, McDonough AA, Peti-Peterdi J. Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure. Cell Commun Adhes. 2008 May; 15(1):219-30. PMID: 18649192.
      View in: PubMed
    51. Petrovic S, Barone S, Wang Z, McDonough AA, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008; 28(2):330-8. PMID: 18046080; PMCID: PMC2785905.
    52. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. PMID: 18003746.
      View in: PubMed
    53. Yang LE, Leong PK, McDonough AA. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1197-208. PMID: 17652375.
      View in: PubMed
    54. Lee FN, Oh G, McDonough AA, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. PMID: 17522262.
      View in: PubMed
    55. Sandberg MB, Riquier AD, Pihakaski-Maunsbach K, McDonough AA, Maunsbach AB. ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane. Am J Physiol Renal Physiol. 2007 Sep; 293(3):F662-9. PMID: 17507603.
      View in: PubMed
    56. Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough AA, Cohen MB. The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81. PMID: 16819406.
      View in: PubMed
    57. Sandberg MB, Maunsbach AB, McDonough AA. Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F503-8. PMID: 16554416.
      View in: PubMed
    58. Leong PK, Yang LE, Landon CS, McDonough AA, Yip KP. Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1543-50. PMID: 16390865.
      View in: PubMed
    59. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. PMID: 16354756.
      View in: PubMed
    60. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F854-63. PMID: 16263808.
      View in: PubMed
    61. McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. PMID: 16139689.
      View in: PubMed
    62. Yang LE, Maunsbach AB, Leong PK, McDonough AA. Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension. J Am Soc Nephrol. 2005 Oct; 16(10):2890-6. PMID: 16107581.
      View in: PubMed
    63. Yang LE, Maunsbach AB, Leong PK, McDonough AA. Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F896-906. PMID: 15265767.
      View in: PubMed
    64. Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. PMID: 15213056.
      View in: PubMed
    65. Leong PK, Yang LE, Lin HW, Holstein-Rathlou NH, McDonough AA. Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na+ transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R878-85. PMID: 15205183.
      View in: PubMed
    66. McDonough AA, Biemesderfer D. Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):533-41. PMID: 12920402.
      View in: PubMed
    67. Yang LE, Leong PK, Guzman JP, Rhee MS, McDonough AA. Modest K+ restriction provokes insulin resistance of cellular K+ uptake without decrease in plasma K. Ann N Y Acad Sci. 2003 Apr; 986:625-7. PMID: 12763903.
      View in: PubMed
    68. McDonough AA, Leong PK, Yang LE. Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. Ann N Y Acad Sci. 2003 Apr; 986:669-77. PMID: 12763917.
      View in: PubMed
    69. Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA. Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Am J Physiol Renal Physiol. 2003 May; 284(5):F1056-65. PMID: 12554635.
      View in: PubMed
    70. Leong PK, Yang LE, Holstein-Rathlou NH, McDonough AA. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1142-50. PMID: 12372791.
      View in: PubMed
    71. Leong PK, Zhang Y, Yang LE, Holstein-Rathlou NH, McDonough AA. Diuretic response to acute hypertension is blunted during angiotensin II clamp. Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R837-42. PMID: 12228052.
      View in: PubMed
    72. Yang LE, Leong PK, Ye S, Campese VM, McDonough AA. Responses of proximal tubule sodium transporters to acute injury-induced hypertension. Am J Physiol Renal Physiol. 2003 Feb; 284(2):F313-22. PMID: 12388425.
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    73. McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. PMID: 11997312.
      View in: PubMed
    74. Choi CS, Lee FN, McDonough AA, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. PMID: 11916907.
      View in: PubMed
    75. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
      View in: PubMed
    76. McDonough AA, Velotta JB, Schwinger RH, Philipson KD, Farley RA. The cardiac sodium pump: structure and function. Basic Res Cardiol. 2002; 97 Suppl 1:I19-24. PMID: 12479229.
      View in: PubMed
    77. Müller-Ehmsen J, McDonough AA, Farley RA, Schwinger RH. Sodium pump isoform expression in heart failure: implication for treatment. Basic Res Cardiol. 2002; 97 Suppl 1:I25-30. PMID: 12479230.
      View in: PubMed
    78. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. Downstream shift in sodium pump activity along the nephron during acute hypertension. J Am Soc Nephrol. 2001 Nov; 12(11):2231-40. PMID: 11675399.
      View in: PubMed
    79. Müller-Ehmsen J, Juvvadi P, Thompson CB, Tumyan L, Croyle M, Lingrel JB, Schwinger RH, McDonough AA, Farley RA. Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1355-64. PMID: 11546674.
      View in: PubMed
    80. Wang J, Velotta JB, McDonough AA, Farley RA. All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1336-43. PMID: 11546672.
      View in: PubMed
    81. Duchesne R, Klein JD, Velotta JB, Doran JJ, Rouillard P, Roberts BR, McDonough AA, Sands JM. UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure. Circ Res. 2001 Jul 20; 89(2):139-45. PMID: 11463720.
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    82. Müller-Ehmsen J, Wang J, Schwinger RH, McDonough AA. Region specific regulation of sodium pump isoform and Na,Ca-exchanger expression in the failing human heart--right atrium vs left ventricle. Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):373-81. PMID: 11357898.
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    83. Thompson CB, Dorup I, Ahn J, Leong PK, McDonough AA. Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C509-16. PMID: 11171570.
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    90. Schwinger RH, Wang J, Frank K, Müller-Ehmsen J, Brixius K, McDonough AA, Erdmann E. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation. 1999 Apr 27; 99(16):2105-12. PMID: 10217649.
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    95. Guillery EN, Huss DJ, McDonough AA, Klein LC. Posttranscriptional upregulation of Na(+)-K(+)-ATPase activity in newborn guinea pig renal cortex. Am J Physiol. 1997 Aug; 273(2 Pt 2):F254-63. PMID: 9277586.
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    96. Thompson CB, McDonough AA. Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem. 1996 Dec 20; 271(51):32653-8. PMID: 8955095.
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    99. McDonough AA, Zhang Y, Shin V, Frank JS. Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1221-7. PMID: 8928749.
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    103. McDonough AA, Wang J, Farley RA. Significance of sodium pump isoforms in digitalis therapy. J Mol Cell Cardiol. 1995 Apr; 27(4):1001-9. PMID: 7563097.
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    105. Hensley CB, Bersohn MM, Sarma JS, Singh BN, McDonough AA. Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle. J Mol Cell Cardiol. 1994 Apr; 26(4):417-24. PMID: 8071999.
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    106. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. PMID: 8147886.
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    108. Bradley ME, Azuma KK, McDonough AA, Mircheff AK, Wood RL. Surface and intracellular pools of Na,K-ATPase catalytic and immuno-activities in rat exorbital lacrimal gland. Exp Eye Res. 1993 Oct; 57(4):403-13. PMID: 8282026.
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    110. McDonough AA, Farley RA. Regulation of Na,K-ATPase activity. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):725-34. PMID: 7922215.
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    114. Mircheff AK, Bowen JW, Yiu SC, McDonough AA. Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. PMID: 1311503.
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    116. McDonough AA, Hensley CB, Azuma KK. Differential regulation of sodium pump isoforms in heart. Semin Nephrol. 1992 Jan; 12(1):49-55. PMID: 1312744.
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    119. Horowitz B, Hensley CB, Quintero M, Azuma KK, Putnam D, McDonough AA. Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone. J Biol Chem. 1990 Aug 25; 265(24):14308-14. PMID: 2167313.
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    120. McDonough AA, Tang MJ, Lescale-Matys L. Ionic regulation of the biosynthesis of NaK-ATPase subunits. Semin Nephrol. 1990 Jul; 10(4):400-9. PMID: 2166328.
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