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Alicia A. McDonough, PhD, FAHA

Title(s)Professor of Physiology and Neuroscience
Phone+1 323 442 1238
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    Collapse Biography 
    Collapse Awards and Honors
    Case Western School of Medicine2019Ulrich Hopfer Lectureship
    American Physiological Society Epithelial Transport Group2018Steve Hebert Lecturer
    University of Southern California2018Phi Kappa Phi Faculty Recognition Award
    American Society of Nephrology2017Robert W. Schrier Endowed Lectureship
    Medical College of Wisconsin2016J.J. Smith Endowed Lecture
    KCVD Young Investigator Symposium2016Keynote Speaker ASN Kidney Week
    Kansas State Univ. Veterinary Medicine2015Clarenberg Distinguished Lecture
    AHA Kidney in Cardiovascular Disease Council2014Donald Seldin Lecture
    SUNY Buffalo2010Suk Ki Hong Memorial Lecturer
    American Physiological Society2009Ernest H. Starling Distinguished Lectureship
    American Heart Association1984  - 1989Established Investigator Award
    Keck School of Medicine2007  - 2018Outstanding Teaching Awards: '07, '12, '17

    Collapse Research 
    Collapse Research Activities and Funding
    Development of a new method for estimating potassium fluxes in vivo using stable potassium isotope ratios
    University Kidney Research Organization UKRO - PilotJun 1, 2019 - May 31, 2020
    Role: Co-Investigator
    Role Description: Conduct experiments in rats to assess potassium fluxes.
    The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertension
    NIH R01DK118019Mar 1, 2019 - Feb 28, 2023
    Role: Co-Investigator
    Impact of Diabetes on Renal Transporters in females and males
    NIH - DIACOMP (diabetes complications) U24 DK115255Mar 1, 2019 - Mar 1, 2020
    Role: PI - subcontract from DIACOMP
    Sodium transporter regulation during hypertension
    NIH/NIDDK R01DK083785Apr 1, 2009 - Mar 31, 2020
    Role: Principal Investigator
    Regulation of Na-CI cotransporter (NCC) subcellular distribution in DCT
    NIH/NHLBI R21HL085388Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    EXTRA-RENAL REGULATION OF POTASSIUM HOMEOSTASIS
    NIH/NIDDK R01DK057678May 1, 2001 - Feb 28, 2006
    Role: Principal Investigator
    Regulation of Sodium Transport in the Kidney
    NIH/NIDDK R01DK034316Jul 1, 1984 - Mar 31, 2010
    Role: Principal Investigator
    REGULATION OF SODIUM PUMPS IN THE KIDNEY
    NIH/NIADDK R01AM034316Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News
    Collapse Featured Presentations
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Edwards A, McDonough AA. Impact of Angiotensin II-mediated stimulation of sodium transporters in the nephron assessed by computational modelling. Am J Physiol Renal Physiol. 2019 Oct 28. PMID: 31657247.
      View in: PubMed
    2. Hu R, McDonough AA, Layton AT. Functional implications of the differences in transporters' abundance along the rat nephron: modeling and analysis. Am J Physiol Renal Physiol. 2019 Sep 30. PMID: 31566436.
      View in: PubMed
    3. Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF. The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease. J Am Soc Nephrol. 2018 10; 29(10):2546-2561. PMID: 30185469.
      View in: PubMed
    4. Li Q, McDonough AA, Layton HE, Layton AT. Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F692-F700. PMID: 29846110.
      View in: PubMed
    5. Varasteh Kia M, Barone S, McDonough AA, Zahedi K, Xu J, Soleimani M. Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis. Cell Physiol Biochem. 2018; 45(4):1551-1565. PMID: 29482189.
      View in: PubMed
    6. van Haaster MC, McDonough AA, Gurley SB. Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. PMID: 29045337.
      View in: PubMed
    7. Hyndman KA, Mironova EV, Giani JF, Dugas C, Collins J, McDonough AA, Stockand JD, Pollock JS. Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways. J Am Heart Assoc. 2017 Oct 24; 6(10). PMID: 29066445.
      View in: PubMed
    8. Prieto MC, Reverte V, Mamenko M, Kuczeriszka M, Veiras LC, Rosales CB, McLellan M, Gentile O, Jensen VB, Ichihara A, McDonough AA, Pochynyuk OM, Gonzalez AA. Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice. Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1243-F1253. PMID: 28814438.
      View in: PubMed
    9. Veiras LC, Girardi ACC, Curry J, Pei L, Ralph DL, Tran A, Castelo-Branco RC, Pastor-Soler N, Arranz CT, Yu ASL, McDonough AA. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017 Dec; 28(12):3504-3517. PMID: 28774999.
      View in: PubMed
    10. McDonough AA, Youn JH. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 03; 32(2):100-111. PMID: 28202621.
      View in: PubMed
    11. McDonough AA, Veiras LC, Guevara CA, Ralph DL. Cardiovascular benefits associated with higher dietary K+ vs. lower dietary Na+: evidence from population and mechanistic studies. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E348-E356. PMID: 28174181.
      View in: PubMed
    12. Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH. Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. J Am Soc Nephrol. 2017 Jun; 28(6):1826-1837. PMID: 28062568.
      View in: PubMed
    13. Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA. Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity. Kidney Int. 2017 04; 91(4):856-867. PMID: 27988209.
      View in: PubMed
    14. Veiras LC, Han J, Ralph DL, McDonough AA. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension. Hypertension. 2016 10; 68(4):904-12. PMID: 27600183.
      View in: PubMed
    15. McDonough AA. ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule. Kidney Int Rep. 2016 Sep; 1(3):166-176. PMID: 27840855.
      View in: PubMed
    16. Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 07 01; 126(7):2509-18. PMID: 27214555.
      View in: PubMed
    17. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 07; 68(1):167-74. PMID: 27141060.
      View in: PubMed
    18. Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough AA, Griffiths R, Sparks MA, Jeffs AD, Crowley SD. Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab. 2016 Feb 09; 23(2):360-8. PMID: 26712462.
      View in: PubMed
    19. Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough AA, Girardi AC. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. PMID: 26447224.
      View in: PubMed
    20. Nguyen MT, Han J, Ralph DL, Veiras LC, McDonough AA. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015 Sep; 3(9). PMID: 26347505.
      View in: PubMed
    21. Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. PMID: 26246427.
      View in: PubMed
    22. Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA. Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme. Hypertension. 2015 Sep; 66(3):534-42. PMID: 26150439.
      View in: PubMed
    23. McDonough AA, Nguyen MT. Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension. Hypertension. 2015 Sep; 66(3):450-5. PMID: 26101347.
      View in: PubMed
    24. West CA, McDonough AA, Masilamani SM, Verlander JW, Baylis C. Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F63-70. PMID: 25925254.
      View in: PubMed
    25. Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE. The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol. 2015 Apr; 21:73-81. PMID: 25616034.
      View in: PubMed
    26. Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-?-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar; 65(3):569-76. PMID: 25601932.
      View in: PubMed
    27. McDonough AA, Veiras LC, Minas JN, Ralph DL. Considerations when quantitating protein abundance by immunoblot. Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. PMID: 25540176.
      View in: PubMed
    28. Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 01; 2(12). PMID: 25472608.
      View in: PubMed
    29. Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J. Local pH domains regulate NHE3-mediated Na? reabsorption in the renal proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1249-62. PMID: 25298526.
      View in: PubMed
    30. Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014 Sep; 16(9):477. PMID: 25097114.
      View in: PubMed
    31. Patel HH, McDonough AA. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. PMID: 25031018.
      View in: PubMed
    32. Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. PMID: 25012170.
      View in: PubMed
    33. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. PMID: 24598799.
      View in: PubMed
    34. McDonough A, Hoang AN, Monterrubio AM, Greenhalgh S, Martínez-Cerdeño V. Compression injury in the mouse spinal cord elicits a specific proliferative response and distinct cell fate acquisition along rostro-caudal and dorso-ventral axes. Neuroscience. 2013 Dec 19; 254:1-17. PMID: 24042034.
      View in: PubMed
    35. Nguyen MT, Lee DH, Delpire E, McDonough AA. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. PMID: 23720346.
      View in: PubMed
    36. McDonough AA, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. PMID: 23633048.
      View in: PubMed
    37. Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013 May; 123(5):2011-23. PMID: 23619363.
      View in: PubMed
    38. Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na?/H? exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug; 91(8):951-63. PMID: 23508938.
      View in: PubMed
    39. Lee DH, Maunsbach AB, Riquier-Brison AD, Nguyen MT, Fenton RA, Bachmann S, Yu AS, McDonough AA. Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties. Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C147-63. PMID: 23114965.
      View in: PubMed
    40. McDonough AA, Nguyen MT. How does potassium supplementation lower blood pressure? Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1224-5. PMID: 22550158.
      View in: PubMed
    41. Nguyen MT, Yang LE, Fletcher NK, Lee DH, Kocinsky H, Bachmann S, Delpire E, McDonough AA. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron. Am J Physiol Renal Physiol. 2012 Jul 01; 303(1):F92-104. PMID: 22496411.
      View in: PubMed
    42. Avner ED, McDonough AA, Sweeney WE. Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1434-5. PMID: 22403786.
      View in: PubMed
    43. Gurley SB, Riquier-Brison ADM, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 06; 13(4):469-475. PMID: 21459331.
      View in: PubMed
    44. McDonough AA. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R851-61. PMID: 20106993.
      View in: PubMed
    45. Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, McDonough AA. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010 Jan; 298(1):F177-86. PMID: 19864301.
      View in: PubMed
    46. McDonough AA. Motoring down the microvilli. Focus on "PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI". Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1331-2. PMID: 19776391.
      View in: PubMed
    47. Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough AA, Bloch W, Schwinger RH, Müller-Ehmsen J. Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur J Pharmacol. 2009 Nov 10; 622(1-3):7-14. PMID: 19751721.
      View in: PubMed
    48. Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25. PMID: 19414841.
      View in: PubMed
    49. Riquier AD, Lee DH, McDonough AA. Renal NHE3 and NaPi2 partition into distinct membrane domains. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C900-10. PMID: 19158399.
      View in: PubMed
    50. Lee DH, Riquier AD, Yang LE, Leong PK, Maunsbach AB, McDonough AA. Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F810-8. PMID: 19144688.
      View in: PubMed
    51. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. PMID: 18759636.
      View in: PubMed
    52. Hak E, Grobbee DE, Sanders EA, Verheij TJ, Bolkenbaas M, Huijts SM, Gruber WC, Tansey S, McDonough A, Thoma B, Patterson S, van Alphen AJ, Bonten MJ. Rationale and design of CAPITA: a RCT of 13-valent conjugated pneumococcal vaccine efficacy among older adults. Neth J Med. 2008 Oct; 66(9):378-83. PMID: 18990781.
      View in: PubMed
    53. Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough AA. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1003-16. PMID: 18653479.
      View in: PubMed
    54. Hanner F, Schnichels M, Zheng-Fischhöfer Q, Yang LE, Toma I, Willecke K, McDonough AA, Peti-Peterdi J. Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure. Cell Commun Adhes. 2008 May; 15(1):219-30. PMID: 18649192.
      View in: PubMed
    55. Petrovic S, Barone S, Wang Z, McDonough AA, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008; 28(2):330-8. PMID: 18046080.
      View in: PubMed
    56. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. PMID: 18003746.
      View in: PubMed
    57. Yang LE, Leong PK, McDonough AA. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1197-208. PMID: 17652375.
      View in: PubMed
    58. Lee FN, Oh G, McDonough AA, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. PMID: 17522262.
      View in: PubMed
    59. Sandberg MB, Riquier AD, Pihakaski-Maunsbach K, McDonough AA, Maunsbach AB. ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane. Am J Physiol Renal Physiol. 2007 Sep; 293(3):F662-9. PMID: 17507603.
      View in: PubMed
    60. Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough AA, Cohen MB. The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81. PMID: 16819406.
      View in: PubMed
    61. Sandberg MB, Maunsbach AB, McDonough AA. Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F503-8. PMID: 16554416.
      View in: PubMed
    62. Leong PK, Yang LE, Landon CS, McDonough AA, Yip KP. Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1543-50. PMID: 16390865.
      View in: PubMed
    63. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. PMID: 16354756.
      View in: PubMed
    64. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough AA. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F854-63. PMID: 16263808.
      View in: PubMed
    65. McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. PMID: 16139689.
      View in: PubMed
    66. Yang LE, Maunsbach AB, Leong PK, McDonough AA. Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension. J Am Soc Nephrol. 2005 Oct; 16(10):2890-6. PMID: 16107581.
      View in: PubMed
    67. Yang LE, Maunsbach AB, Leong PK, McDonough AA. Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F896-906. PMID: 15265767.
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    68. Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. PMID: 15213056.
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    69. Leong PK, Yang LE, Lin HW, Holstein-Rathlou NH, McDonough AA. Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na+ transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R878-85. PMID: 15205183.
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    70. McDonough AA, Biemesderfer D. Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):533-41. PMID: 12920402.
      View in: PubMed
    71. Yang LE, Leong PK, Guzman JP, Rhee MS, McDonough AA. Modest K+ restriction provokes insulin resistance of cellular K+ uptake without decrease in plasma K. Ann N Y Acad Sci. 2003 Apr; 986:625-7. PMID: 12763903.
      View in: PubMed
    72. McDonough AA, Leong PK, Yang LE. Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. Ann N Y Acad Sci. 2003 Apr; 986:669-77. PMID: 12763917.
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    73. Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough AA. Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Am J Physiol Renal Physiol. 2003 May; 284(5):F1056-65. PMID: 12554635.
      View in: PubMed
    74. Leong PK, Yang LE, Holstein-Rathlou NH, McDonough AA. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1142-50. PMID: 12372791.
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    75. Leong PK, Zhang Y, Yang LE, Holstein-Rathlou NH, McDonough AA. Diuretic response to acute hypertension is blunted during angiotensin II clamp. Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R837-42. PMID: 12228052.
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    76. Yang LE, Leong PK, Ye S, Campese VM, McDonough AA. Responses of proximal tubule sodium transporters to acute injury-induced hypertension. Am J Physiol Renal Physiol. 2003 Feb; 284(2):F313-22. PMID: 12388425.
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    77. McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. PMID: 11997312.
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    78. Choi CS, Lee FN, McDonough AA, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. PMID: 11916907.
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    79. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
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    80. McDonough AA, Velotta JB, Schwinger RH, Philipson KD, Farley RA. The cardiac sodium pump: structure and function. Basic Res Cardiol. 2002; 97 Suppl 1:I19-24. PMID: 12479229.
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    81. Müller-Ehmsen J, McDonough AA, Farley RA, Schwinger RH. Sodium pump isoform expression in heart failure: implication for treatment. Basic Res Cardiol. 2002; 97 Suppl 1:I25-30. PMID: 12479230.
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    82. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. Downstream shift in sodium pump activity along the nephron during acute hypertension. J Am Soc Nephrol. 2001 Nov; 12(11):2231-40. PMID: 11675399.
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    83. Müller-Ehmsen J, Juvvadi P, Thompson CB, Tumyan L, Croyle M, Lingrel JB, Schwinger RH, McDonough AA, Farley RA. Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1355-64. PMID: 11546674.
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    84. Wang J, Velotta JB, McDonough AA, Farley RA. All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1336-43. PMID: 11546672.
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    85. Duchesne R, Klein JD, Velotta JB, Doran JJ, Rouillard P, Roberts BR, McDonough AA, Sands JM. UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure. Circ Res. 2001 Jul 20; 89(2):139-45. PMID: 11463720.
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    86. Thompson CB, Dorup I, Ahn J, Leong PK, McDonough AA. Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C509-16. PMID: 11171570.
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    87. Müller-Ehmsen J, Wang J, Schwinger RH, McDonough AA. Region specific regulation of sodium pump isoform and Na,Ca-exchanger expression in the failing human heart--right atrium vs left ventricle. Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):373-81. PMID: 11357898.
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    88. Choi CS, Thompson CB, Leong PK, McDonough AA, Youn JH. Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. PMID: 11133519.
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    89. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough AA. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F358-69. PMID: 10919857.
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    90. Nakhoul F, Thompson CB, McDonough AA. Developmental change in Na,K-ATPase alpha1 and beta1 expression in normal and hypothyroid rat renal cortex. Am J Nephrol. 2000 May-Jun; 20(3):225-31. PMID: 10878407.
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    91. Magyar CE, McDonough AA. Molecular mechanisms of sodium transport inhibition in proximal tubule during acute hypertension. Curr Opin Nephrol Hypertens. 2000 Mar; 9(2):149-56. PMID: 10757220.
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    92. Thompson CB, Choi C, Youn JH, McDonough AA. Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 06; 276(6):C1411-9. PMID: 10362605.
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    93. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough AA. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol. 1999 05; 276(5):F711-9. PMID: 10330053.
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    94. Schwinger RH, Wang J, Frank K, Müller-Ehmsen J, Brixius K, McDonough AA, Erdmann E. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation. 1999 Apr 27; 99(16):2105-12. PMID: 10217649.
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    95. McDonough AA. Can ENaC regulate ICF as well as ECF volume? Focus on "osmotic pressure regulates alpha beta gamma-rENaC expressed in Xenopus oocytes". Am J Physiol. 1998 11; 275(5):C1179-81. PMID: 9814963.
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    96. Yip KP, Tse CM, McDonough AA, Marsh DJ. Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am J Physiol. 1998 10; 275(4):F565-75. PMID: 9755128.
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    97. Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough AA. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am J Physiol. 1998 04; 274(4):C1090-100. PMID: 9575807.
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    98. Zhang YB, Magyar CE, Holstein-Rathlou NH, McDonough AA. The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension. J Am Soc Nephrol. 1998 Apr; 9(4):531-7. PMID: 9555654.
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    99. Guillery EN, Huss DJ, McDonough AA, Klein LC. Posttranscriptional upregulation of Na(+)-K(+)-ATPase activity in newborn guinea pig renal cortex. Am J Physiol. 1997 Aug; 273(2 Pt 2):F254-63. PMID: 9277586.
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    100. Thompson CB, McDonough AA. Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem. 1996 Dec 20; 271(51):32653-8. PMID: 8955095.
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    101. Wang J, Schwinger RH, Frank K, Müller-Ehmsen J, Martin-Vasallo P, Pressley TA, Xiang A, Erdmann E, McDonough AA. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart. J Clin Invest. 1996 Oct 01; 98(7):1650-8. PMID: 8833915.
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    102. Zhang Y, Mircheff AK, Hensley CB, Magyar CE, Warnock DG, Chambrey R, Yip KP, Marsh DJ, Holstein-Rathlou NH, McDonough AA. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol. 1996 Jun; 270(6 Pt 2):F1004-14. PMID: 8764320.
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    103. McDonough AA, Zhang Y, Shin V, Frank JS. Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1221-7. PMID: 8928749.
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    104. McDonough AA, Thompson CB. Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation. Acta Physiol Scand. 1996 Mar; 156(3):295-304. PMID: 8729690.
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    105. Azuma KK, Balkovetz DF, Magyar CE, Lescale-Matys L, Zhang Y, Chambrey R, Warnock DG, McDonough AA. Renal Na+/H+ exchanger isoforms and their regulation by thyroid hormone. Am J Physiol. 1996 Feb; 270(2 Pt 1):C585-92. PMID: 8779923.
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    106. Magyar CE, Wang J, Azuma KK, McDonough AA. Reciprocal regulation of cardiac Na-K-ATPase and Na/Ca exchanger: hypertension, thyroid hormone, development. Am J Physiol. 1995 Sep; 269(3 Pt 1):C675-82. PMID: 7573397.
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    107. McDonough AA, Wang J, Farley RA. Significance of sodium pump isoforms in digitalis therapy. J Mol Cell Cardiol. 1995 Apr; 27(4):1001-9. PMID: 7563097.
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    108. McDonough AA, Magyar CE, Komatsu Y. Expression of Na(+)-K(+)-ATPase alpha- and beta-subunits along rat nephron: isoform specificity and response to hypokalemia. Am J Physiol. 1994 Oct; 267(4 Pt 1):C901-8. PMID: 7943283.
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    109. Hensley CB, Bersohn MM, Sarma JS, Singh BN, McDonough AA. Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle. J Mol Cell Cardiol. 1994 Apr; 26(4):417-24. PMID: 8071999.
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    110. Wang L, McComb JG, Weiss MH, McDonough AA, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. PMID: 8147886.
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    111. Lescale-Matys L, Putnam DS, McDonough AA. Surplus Na+ pumps: how low-K(+)-incubated LLC-PK1 cells respond to K+ restoration. Am J Physiol. 1993 Oct; 265(4 Pt 1):C887-92. PMID: 8238313.
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    112. Bradley ME, Azuma KK, McDonough AA, Mircheff AK, Wood RL. Surface and intracellular pools of Na,K-ATPase catalytic and immuno-activities in rat exorbital lacrimal gland. Exp Eye Res. 1993 Oct; 57(4):403-13. PMID: 8282026.
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    113. Azuma KK, Hensley CB, Tang MJ, McDonough AA. Thyroid hormone specifically regulates skeletal muscle Na(+)-K(+)-ATPase alpha 2- and beta 2-isoforms. Am J Physiol. 1993 Sep; 265(3 Pt 1):C680-7. PMID: 8214025.
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    114. McDonough AA, Farley RA. Regulation of Na,K-ATPase activity. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):725-34. PMID: 7922215.
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    115. Zlokovic BV, Mackic JB, Wang L, McComb JG, McDonough A. Differential expression of Na,K-ATPase alpha and beta subunit isoforms at the blood-brain barrier and the choroid plexus. J Biol Chem. 1993 Apr 15; 268(11):8019-25. PMID: 8385133.
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    116. Lescale-Matys L, Putnam DS, McDonough AA. Na(+)-K(+)-ATPase alpha 1- and beta 1-subunit degradation: evidence for multiple subunit specific rates. Am J Physiol. 1993 Mar; 264(3 Pt 1):C583-90. PMID: 8384785.
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    117. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. PMID: 8392783.
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    118. McDonough AA, Azuma KK, Lescale-Matys L, Tang MJ, Nakhoul F, Hensley CB, Komatsu Y. Physiologic rationale for multiple sodium pump isoforms. Differential regulation of alpha 1 vs alpha 2 by ionic stimuli. Ann N Y Acad Sci. 1992 Nov 30; 671:156-68; discussion 168-9. PMID: 1337670.
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    119. Tang MJ, McDonough AA. Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells. Am J Physiol. 1992 Aug; 263(2 Pt 1):C436-42. PMID: 1381148.
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    120. Hensley CB, Azuma KK, Tang MJ, McDonough AA. Thyroid hormone induction of rat myocardial Na(+)-K(+)-ATPase: alpha 1-, alpha 2-, and beta 1-mRNA and -protein levels at steady state. Am J Physiol. 1992 Feb; 262(2 Pt 1):C484-92. PMID: 1311504.
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    121. Mircheff AK, Bowen JW, Yiu SC, McDonough AA. Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. PMID: 1311503.
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    122. McDonough AA, Hensley CB, Azuma KK. Differential regulation of sodium pump isoforms in heart. Semin Nephrol. 1992 Jan; 12(1):49-55. PMID: 1312744.
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    123. Nakhoul F, Kayne LH, Brautbar N, Hu MS, McDonough A, Eggena P, Golub MS, Berger M, Chang CT, Jamgotchian N. Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat. Toxicol Ind Health. 1992 Jan-Apr; 8(1-2):89-102. PMID: 1542888.
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    124. Azuma KK, Hensley CB, Putnam DS, McDonough AA. Hypokalemia decreases Na(+)-K(+)-ATPase alpha 2- but not alpha 1-isoform abundance in heart, muscle, and brain. Am J Physiol. 1991 May; 260(5 Pt 1):C958-64. PMID: 1852110.
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    125. Lu Y, McDonough A, Farley RA, Warren DW. Regulation of testicular P-450 cholesterol side-chain cleavage and P-450 C17-20 lyase/C17 hydroxylase enzymes in the neonatal and adult rat. Acta Endocrinol (Copenh). 1991 Apr; 124(4):449-54. PMID: 2031442.
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    126. Lescale-Matys L, Hensley CB, Crnkovic-Markovic R, Putnam DS, McDonough AA. Low K+ increases Na,K-ATPase abundance in LLC-PK1/Cl4 cells by differentially increasing beta, and not alpha, subunit mRNA. J Biol Chem. 1990 Oct 15; 265(29):17935-40. PMID: 2170401.
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    127. Horowitz B, Hensley CB, Quintero M, Azuma KK, Putnam D, McDonough AA. Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone. J Biol Chem. 1990 Aug 25; 265(24):14308-14. PMID: 2167313.
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    128. McDonough AA, Tang MJ, Lescale-Matys L. Ionic regulation of the biosynthesis of NaK-ATPase subunits. Semin Nephrol. 1990 Jul; 10(4):400-9. PMID: 2166328.
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    129. McDonough AA, Geering K, Farley RA. The sodium pump needs its beta subunit. FASEB J. 1990 Apr 01; 4(6):1598-605. PMID: 2156741.
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    130. Qian NX, Jones M, McDonough A, Englesberg E. alar4, a constitutive mutant of the A system for amino acid transport, has increased abundance of the Na+,K+-ATPase and mRNA for alpha 1 subunit of this enzyme. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7984-8. PMID: 2554299.
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    131. Schmitt CA, McDonough AA. Thyroid hormone regulates alpha and alpha + isoforms of Na,K-ATPase during development in neonatal rat brain. J Biol Chem. 1988 Nov 25; 263(33):17643-9. PMID: 2846574.
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    132. Norman JT, Bohman RE, Fischmann G, Bowen JW, McDonough A, Slamon D, Fine LG. Patterns of mRNA expression during early cell growth differ in kidney epithelial cells destined to undergo compensatory hypertrophy versus regenerative hyperplasia. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6768-72. PMID: 3413124.
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    133. McDonough AA, Brown TA, Horowitz B, Chiu R, Schlotterbeck J, Bowen J, Schmitt CA. Thyroid hormone coordinately regulates Na+-K+-ATPase alpha- and beta-subunit mRNA levels in kidney. Am J Physiol. 1988 Feb; 254(2 Pt 1):C323-9. PMID: 2831727.
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    134. McDonough AA, Schmitt CA. Isozymes of dog heart Na+-K+-ATPase are immunologically similar to isozymes in brain. Am J Physiol. 1987 Dec; 253(6 Pt 1):C862-5. PMID: 2827499.
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    135. Philipson KD, McDonough AA, Frank JS, Ward R. Enrichment of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by alkaline extraction. Biochim Biophys Acta. 1987 May 12; 899(1):59-66. PMID: 3567192.
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    136. Brown TA, Horowitz B, Miller RP, McDonough AA, Farley RA. Molecular cloning and sequence analysis of the (Na+ + K+)-ATPase beta subunit from dog kidney. Biochim Biophys Acta. 1987 Apr 08; 912(2):244-53. PMID: 3030434.
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    137. Bowen JW, McDonough A. Pretranslational regulation of Na-K-ATPase in cultured canine kidney cells by low K+. Am J Physiol. 1987 Feb; 252(2 Pt 1):C179-89. PMID: 3030119.
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    138. Schmitt CA, McDonough AA. Developmental and thyroid hormone regulation of two molecular forms of Na+-K+-ATPase in brain. J Biol Chem. 1986 Aug 05; 261(22):10439-44. PMID: 3015931.
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    139. Osawa S, Chiu RH, McDonough A, Miller TB, Johnson GL. Isolation of partial cDNAs for rat liver and muscle glycogen phosphorylase isozymes. FEBS Lett. 1986 Jul 07; 202(2):282-8. PMID: 2424788.
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    140. Conteas CN, McDonough AA, Kozlowski TR, Hensley CB, Wood RL, Mircheff AK. Mapping subcellular distribution of Na+-K+-ATPase in rat parotid gland. Am J Physiol. 1986 Mar; 250(3 Pt 1):C430-41. PMID: 3006505.
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    141. McDonough A. Immunodetection of Na,K-ATPase in guinea-pig retinal layers, cornea and lens. Exp Eye Res. 1985 May; 40(5):667-74. PMID: 2988990.
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    142. McDonough A, Schmitt C. Comparison of subunits of cardiac, brain, and kidney Na+-K+-ATPase. Am J Physiol. 1985 Mar; 248(3 Pt 1):C247-51. PMID: 2983564.
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    143. Hiatt A, McDonough AA, Edelman IS. Assembly of the (Na+ + K+)-adenosine triphosphatase. Post-translational membrane integration of the alpha subunit. J Biol Chem. 1984 Feb 25; 259(4):2629-35. PMID: 6199349.
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    144. McDonough AA, Hiatt A, Edelman IS. Characteristics of antibodies to guinea pig (Na+ + K+)-adenosine triphosphatase and their use in cell-free synthesis studies. J Membr Biol. 1982; 69(1):13-22. PMID: 6288956.
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    145. Hong SK, Claybaugh JR, Frattali V, Johnson R, Kurata F, Matsuda M, McDonough AA, Paganelli CV, Smith RM, Webb P. Hana kai ii: a 17-day dry saturation dive at 18.6 ATA. III. Body fluid balance. Undersea Biomed Res. 1977 Sep; 4(3):247-65. PMID: 910316.
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