Alicia A. McDonough, PhD, FAHA

Title(s)Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
AddressZNI 101, 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1238
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    Collapse Biography 
    Collapse Awards and Honors
    American Heart Association Hypertension Council2022 Irvine Page & Alba Bradley Lifetime Achievement Award
    International Union of Physiological Scientists2022Robert Pitts Awardee
    Case Western School of Medicine2019Ulrich Hopfer Lectureship
    American Physiological Society Epithelial Transport Group2018Steve Hebert Lecturer
    University of Southern California2018Phi Kappa Phi Faculty Recognition Award
    American Society of Nephrology2017Robert W. Schrier Endowed Lectureship
    Medical College of Wisconsin2016J.J. Smith Endowed Lecture
    American Heart Association KCVD Young Investigator Symposium2016Keynote Speaker ASN Kidney Week
    Kansas State Univ. Veterinary Medicine2015Clarenberg Distinguished Lecture
    American Heart Association Kidney in Cardiovascular Disease Council2014Donald Seldin Lecture
    SUNY Buffalo2010Suk Ki Hong Memorial Lecturer
    American Physiological Society2009Ernest H. Starling Distinguished Lectureship
    Keck School of Medicine2007  - 2018Outstanding Teaching Awards: '07, '12, '17
    American Heart Association1984  - 1989Established Investigator Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Renal electrolyte handling in females vs. males over life cycle
    NIH 2R01DK083785-10A1Aug 29, 2022 - May 31, 2027
    Role: PI
    Description: The blood pressure set point is determined by the kidney, and disruption of kidney function can provoke hypertension, the leading cause of premature death in the developed world. This MPI project aims to advance our understanding of how nephrons adjust operation over life cycle as a function of sex and age (in order to maintain homeostasis and blood pressure), and how kidney function adapts in response to challenges including lactation, menopause, loss/donation of one kidney, and dietary salt. We propose to combine experimental measurements in rats with computational modeling to determine how age- and sex- based differences in kidney fluid and electrolyte handling impact blood pressure regulation (which can guide the appropriate choice of anti-hypertensive therapeutic targets) as a function of sex and stage in life cycle.
    Renal sodium handling in hypertension: impact of age, sex, and dietary potassium
    NIH R56DK123780Sep 14, 2020 - Aug 31, 2021
    Role: Principal Investigator
    Development of a new method for estimating potassium fluxes in vivo using stable potassium isotope ratios
    University Kidney Research Organization UKRO - PilotJun 1, 2019 - May 31, 2020
    Role: Co-Investigator
    Description: Conduct experiments in rats to assess potassium fluxes.
    The interleukin-1 receptor regulates crosstalk between myeloid and renal tubular cells in hypertension
    NIH R01DK118019Mar 1, 2019 - Feb 28, 2023
    Role: Co-Investigator
    Impact of Diabetes on Renal Transporters in females and males
    NIH - DIACOMP (diabetes complications) U24 DK115255Mar 1, 2019 - Mar 1, 2020
    Role: PI - subcontract from DIACOMP
    Sodium transporter regulation during hypertension
    NIH R01DK083785Apr 1, 2009 - Mar 31, 2021
    Role: Principal Investigator
    Regulation of Na-CI cotransporter (NCC) subcellular distribution in DCT
    NIH R21HL085388Aug 1, 2006 - Jul 31, 2009
    Role: Principal Investigator
    EXTRA-RENAL REGULATION OF POTASSIUM HOMEOSTASIS
    NIH R01DK057678May 1, 2001 - Feb 28, 2006
    Role: Principal Investigator
    Regulation of Sodium Transport in the Kidney
    NIH R01DK034316Jul 1, 1984 - Mar 31, 2010
    Role: Principal Investigator
    REGULATION OF SODIUM PUMPS IN THE KIDNEY
    NIH R01AM034316Jul 1, 1984 - Jun 30, 1987
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Our Editorial Fellowship Program: Building Synergism. J Am Soc Nephrol. 2023 12 01; 34(12):1940-1943. Gyarmati G, McDonough AA. PMID: 37902620; PMCID: PMC10703069.
      View in: PubMed   Mentions:    Fields:    
    2. Angiotensin II hypertension along the female rat tubule: predicted impact on coupled transport of Na+ and K. Am J Physiol Renal Physiol. 2023 12 01; 325(6):F733-F749. Edwards A, Ralph DL, Mercado A, McDonough AA. PMID: 37823196; PMCID: PMC10878725.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Sex differences in renal transporters: assessment and functional consequences. Nat Rev Nephrol. 2024 01; 20(1):21-36. McDonough AA, Harris AN, Xiong LI, Layton AT. PMID: 37684523.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    4. Sex differences in renal electrolyte transport. Curr Opin Nephrol Hypertens. 2023 09 01; 32(5):467-475. McDonough AA, Layton AT. PMID: 37382185; PMCID: PMC10526720.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Stable potassium isotopes (41K/39K) track transcellular and paracellular potassium transport in biological systems. Front Physiol. 2022; 13:1016242. Higgins JA, Ramos DS, Gili S, Spetea C, Kanoski S, Ha D, McDonough AA, Youn JH. PMID: 36388124; PMCID: PMC9644202.
      View in: PubMed   Mentions: 1  
    6. Cell-Specific Actions of the Prostaglandin E-Prostanoid Receptor 4 Attenuating Hypertension: A Dominant Role for Kidney Epithelial Cells Compared With Macrophages. J Am Heart Assoc. 2022 10 04; 11(19):e026581. Yang T, Song C, Ralph DL, Andrews P, Sparks MA, Koller BH, McDonough AA, Coffman TM. PMID: 36172956; PMCID: PMC9673718.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    7. The Highs and Lows of Potassium Intake in CKD-Does One Size Fit All? J Am Soc Nephrol. 2022 09; 33(9):1638-1640. Terker AS, Saritas T, McDonough AA. PMID: 36630492; PMCID: PMC9529180.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Potassium homeostasis: sensors, mediators, and targets. Pflugers Arch. 2022 08; 474(8):853-867. McDonough AA, Fenton RA. PMID: 35727363; PMCID: PMC10163916.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    9. Estimating in vivo potassium distribution and fluxes with stable potassium isotopes. Am J Physiol Cell Physiol. 2022 03 01; 322(3):C410-C420. Youn JH, Oh YT, Gili S, McDonough AA, Higgins J. PMID: 35080924; PMCID: PMC8917925.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    10. Sex-specific adaptations to high-salt diet preserve electrolyte homeostasis with distinct sodium transporter profiles. Am J Physiol Cell Physiol. 2021 11 01; 321(5):C897-C909. Torres-Pinzon DL, Ralph DL, Veiras LC, McDonough AA. PMID: 34613843; PMCID: PMC8616593.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron. Am J Physiol Renal Physiol. 2021 07 01; 321(1):F69-F81. Nelson JW, McDonough AA, Xiang Z, Ralph DL, Robertson JA, Giani JF, Bernstein KE, Gurley SB. PMID: 34056928; PMCID: PMC8321806.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. Sex differences in solute and water handling in the human kidney: Modeling and functional implications. iScience. 2021 Jun 25; 24(6):102667. Hu R, McDonough AA, Layton AT. PMID: 34169242; PMCID: PMC8209279.
      View in: PubMed   Mentions: 14  
    13. Vascular control of kidney epithelial transporters. Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1080-F1092. Sparks MA, Dilmen E, Ralph DL, Rianto F, Hoang TA, Hollis A, Diaz EJ, Adhikari R, Chew G, Petretto EG, Gurley SB, McDonough AA, Coffman TM. PMID: 33969697; PMCID: PMC8285646.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    14. Impact of casein- versus grain-based diets on rat renal sodium transporters' abundance and regulation. Kidney360. 2021 03; 2(3):519-523. McDonough AA, Veiras LC, McFarlin BE, Ralph DL. PMID: 34095853; PMCID: PMC8174819.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    15. Coordinate adaptations of skeletal muscle and kidney to maintain extracellular [K+] during K+-deficient diet. Am J Physiol Cell Physiol. 2020 10 01; 319(4):C757-C770. McFarlin BE, Chen Y, Priver TS, Ralph DL, Mercado A, Gamba G, Madhur MS, McDonough AA. PMID: 32845718; PMCID: PMC7654654.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    16. Sex differences in solute transport along the nephrons: effects of Na+ transport inhibition. Am J Physiol Renal Physiol. 2020 09 01; 319(3):F487-F505. Hu R, McDonough AA, Layton AT. PMID: 32744084; PMCID: PMC7509281.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    17. α2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease. J Am Soc Nephrol. 2020 04; 31(4):783-798. Hering L, Rahman M, Hoch H, Markó L, Yang G, Reil A, Yakoub M, Gupta V, Potthoff SA, Vonend O, Ralph DL, Gurley SB, McDonough AA, Rump LC, Stegbauer J. PMID: 32086277; PMCID: PMC7191918.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    18. Report of the National Heart, Lung, and Blood Institute Working Group on Hypertension: Barriers to Translation. Hypertension. 2020 04; 75(4):902-917. Sigmund CD, Carey RM, Appel LJ, Arnett DK, Bosworth HB, Cushman WC, Galis ZS, Green Parker M, Hall JE, Harrison DG, McDonough AA, Nicastro HL, Oparil S, Osborn JW, Raizada MK, Wright JD, Oh YS. PMID: 32063061; PMCID: PMC7067675.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    19. Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice. Acta Physiol (Oxf). 2020 05; 229(1):e13448. Veiras LC, McFarlin BE, Ralph DL, Buncha V, Prescott J, Shirvani BS, McDonough JC, Ha D, Giani J, Gurley SB, Mamenko M, McDonough AA. PMID: 31994810; PMCID: PMC7156336.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    20. Moving the Needle on Hypertension: What Knowledge Is Needed? Nutr Today. 2019 Nov-Dec; 54(6):248-256. Frame AA, Farquhar WB, Latulippe ME, McDonough AA, Wainford RD, Wynne BM. PMID: 34092814; PMCID: PMC8174552.
      View in: PubMed   Mentions: 1  
    21. Impact of angiotensin II-mediated stimulation of sodium transporters in the nephron assessed by computational modeling. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1656-F1668. Edwards A, McDonough AA. PMID: 31657247; PMCID: PMC6962509.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    22. Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis. Am J Physiol Renal Physiol. 2019 12 01; 317(6):F1462-F1474. Hu R, McDonough AA, Layton AT. PMID: 31566436; PMCID: PMC7132321.
      View in: PubMed   Mentions: 20     Fields:    Translation:Animals
    23. The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease. J Am Soc Nephrol. 2018 10; 29(10):2546-2561. Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF. PMID: 30185469; PMCID: PMC6171283.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    24. Functional implications of sexual dimorphism of transporter patterns along the rat proximal tubule: modeling and analysis. Am J Physiol Renal Physiol. 2018 09 01; 315(3):F692-F700. Li Q, McDonough AA, Layton HE, Layton AT. PMID: 29846110; PMCID: PMC6172582.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    25. Downregulation of the Cl-/HCO3-Exchanger Pendrin in Kidneys of Mice with Cystic Fibrosis: Role in the Pathogenesis of Metabolic Alkalosis. Cell Physiol Biochem. 2018; 45(4):1551-1565. Varasteh Kia M, Barone S, McDonough AA, Zahedi K, Xu J, Soleimani M. PMID: 29482189.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    26. Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. van Haaster MC, McDonough AA, Gurley SB. PMID: 29045337; PMCID: PMC5818672.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    27. Collecting Duct Nitric Oxide Synthase 1ß Activation Maintains Sodium Homeostasis During High Sodium Intake Through Suppression of Aldosterone and Renal Angiotensin II Pathways. J Am Heart Assoc. 2017 Oct 24; 6(10). Hyndman KA, Mironova EV, Giani JF, Dugas C, Collins J, McDonough AA, Stockand JD, Pollock JS. PMID: 29066445; PMCID: PMC5721879.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    28. Collecting duct prorenin receptor knockout reduces renal function, increases sodium excretion, and mitigates renal responses in ANG II-induced hypertensive mice. Am J Physiol Renal Physiol. 2017 Dec 01; 313(6):F1243-F1253. Prieto MC, Reverte V, Mamenko M, Kuczeriszka M, Veiras LC, Rosales CB, McLellan M, Gentile O, Jensen VB, Ichihara A, McDonough AA, Pochynyuk OM, Gonzalez AA. PMID: 28814438; PMCID: PMC5814641.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    29. Sexual Dimorphic Pattern of Renal Transporters and Electrolyte Homeostasis. J Am Soc Nephrol. 2017 Dec; 28(12):3504-3517. Veiras LC, Girardi ACC, Curry J, Pei L, Ralph DL, Tran A, Castelo-Branco RC, Pastor-Soler N, Arranz CT, Yu ASL, McDonough AA. PMID: 28774999; PMCID: PMC5698077.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    30. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 03; 32(2):100-111. McDonough AA, Youn JH. PMID: 28202621; PMCID: PMC5337831.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimals
    31. Cardiovascular benefits associated with higher dietary K+ vs. lower dietary Na+: evidence from population and mechanistic studies. Am J Physiol Endocrinol Metab. 2017 04 01; 312(4):E348-E356. McDonough AA, Veiras LC, Guevara CA, Ralph DL. PMID: 28174181; PMCID: PMC5406991.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    32. Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. J Am Soc Nephrol. 2017 Jun; 28(6):1826-1837. Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough AA, Le TH. PMID: 28062568; PMCID: PMC5461790.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    33. Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity. Kidney Int. 2017 04; 91(4):856-867. Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA. PMID: 27988209; PMCID: PMC5657384.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    34. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension. Hypertension. 2016 10; 68(4):904-12. Veiras LC, Han J, Ralph DL, McDonough AA. PMID: 27600183; PMCID: PMC5016236.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    35. ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule. Kidney Int Rep. 2016 Sep; 1(3):166-176. McDonough AA. PMID: 27840855; PMCID: PMC5102061.
      View in: PubMed   Mentions: 4  
    36. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 07 01; 126(7):2509-18. Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough AA, Fields TA, Welch WJ, Yu AS. PMID: 27214555; PMCID: PMC4922683.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    37. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 07; 68(1):167-74. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough AA, Madhur MS. PMID: 27141060; PMCID: PMC4900947.
      View in: PubMed   Mentions: 94     Fields:    Translation:AnimalsCells
    38. Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab. 2016 Feb 09; 23(2):360-8. Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough AA, Griffiths R, Sparks MA, Jeffs AD, Crowley SD. PMID: 26712462; PMCID: PMC4749461.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    39. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough AA, Girardi AC. PMID: 26447224; PMCID: PMC5504384.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    40. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015 Sep; 3(9). Nguyen MT, Han J, Ralph DL, Veiras LC, McDonough AA. PMID: 26347505; PMCID: PMC4600373.
      View in: PubMed   Mentions: 29     Fields:    
    41. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough AA, Girardi AC. PMID: 26246427; PMCID: PMC9560057.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    42. Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme. Hypertension. 2015 Sep; 66(3):534-42. Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA. PMID: 26150439; PMCID: PMC4825680.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    43. Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension. Hypertension. 2015 Sep; 66(3):450-5. McDonough AA, Nguyen MT. PMID: 26101347; PMCID: PMC4943879.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    44. Renal NCC is unchanged in the midpregnant rat and decreased in the late pregnant rat despite avid renal Na+ retention. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F63-70. West CA, McDonough AA, Masilamani SM, Verlander JW, Baylis C. PMID: 25925254; PMCID: PMC4490381.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    45. The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol. 2015 Apr; 21:73-81. Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE. PMID: 25616034; PMCID: PMC4380835.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    46. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-γ-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar; 65(3):569-76. Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough AA. PMID: 25601932; PMCID: PMC4326622.
      View in: PubMed   Mentions: 110     Fields:    Translation:Animals
    47. Considerations when quantitating protein abundance by immunoblot. Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. McDonough AA, Veiras LC, Minas JN, Ralph DL. PMID: 25540176; PMCID: PMC4360027.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    48. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 01; 2(12). Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough AA, Sweadner KJ. PMID: 25472608; PMCID: PMC4332208.
      View in: PubMed   Mentions: 5     Fields:    
    49. Local pH domains regulate NHE3-mediated Na⁺ reabsorption in the renal proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 01; 307(11):F1249-62. Brasen JC, Burford JL, McDonough AA, Holstein-Rathlou NH, Peti-Peterdi J. PMID: 25298526; PMCID: PMC4254968.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    50. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014 Sep; 16(9):477. Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA. PMID: 25097114; PMCID: PMC4277187.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    51. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. Patel HH, McDonough AA. PMID: 25031018; PMCID: PMC4166741.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    52. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough AA, Gonzalez-Villalobos RA. PMID: 25012170; PMCID: PMC4243348.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    53. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. PMID: 24598799; PMCID: PMC4010681.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    54. Compression injury in the mouse spinal cord elicits a specific proliferative response and distinct cell fate acquisition along rostro-caudal and dorso-ventral axes. Neuroscience. 2013 Dec 19; 254:1-17. McDonough A, Hoang AN, Monterrubio AM, Greenhalgh S, Martínez-Cerdeño V. PMID: 24042034.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    55. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. Nguyen MT, Lee DH, Delpire E, McDonough AA. PMID: 23720346; PMCID: PMC3891260.
      View in: PubMed   Mentions: 72     Fields:    Translation:Animals
    56. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. McDonough AA, Youn JH. PMID: 23633048; PMCID: PMC3644996.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    57. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013 May; 123(5):2011-23. Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough AA. PMID: 23619363; PMCID: PMC3638907.
      View in: PubMed   Mentions: 112     Fields:    Translation:Animals
    58. Proximal tubule specific knockout of the Na⁺/H⁺ exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug; 91(8):951-63. Li HC, Du Z, Barone S, Rubera I, McDonough AA, Tauc M, Zahedi K, Wang T, Soleimani M. PMID: 23508938; PMCID: PMC3730089.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
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    136. Na(+)-K(+)-ATPase alpha 1- and beta 1-subunit degradation: evidence for multiple subunit specific rates. Am J Physiol. 1993 Mar; 264(3 Pt 1):C583-90. Lescale-Matys L, Putnam DS, McDonough AA. PMID: 8384785.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    137. Expression of Na,K-ATPase at the blood-brain interface. Adv Exp Med Biol. 1993; 331:55-60. Zlokovic BV, Wang L, Mackic JB, Saraj AJ, McComb JG, McDonough A. PMID: 8392783.
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    138. Physiologic rationale for multiple sodium pump isoforms. Differential regulation of alpha 1 vs alpha 2 by ionic stimuli. Ann N Y Acad Sci. 1992 Nov 30; 671:156-68; discussion 168-9. McDonough AA, Azuma KK, Lescale-Matys L, Tang MJ, Nakhoul F, Hensley CB, Komatsu Y. PMID: 1337670.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    139. Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells. Am J Physiol. 1992 Aug; 263(2 Pt 1):C436-42. Tang MJ, McDonough AA. PMID: 1381148.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    140. Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. Mircheff AK, Bowen JW, Yiu SC, McDonough AA. PMID: 1311503.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    141. Thyroid hormone induction of rat myocardial Na(+)-K(+)-ATPase: alpha 1-, alpha 2-, and beta 1-mRNA and -protein levels at steady state. Am J Physiol. 1992 Feb; 262(2 Pt 1):C484-92. Hensley CB, Azuma KK, Tang MJ, McDonough AA. PMID: 1311504.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    142. Differential regulation of sodium pump isoforms in heart. Semin Nephrol. 1992 Jan; 12(1):49-55. McDonough AA, Hensley CB, Azuma KK. PMID: 1312744.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    143. Rapid hypertensinogenic effect of lead: studies in the spontaneously hypertensive rat. Toxicol Ind Health. 1992 Jan-Apr; 8(1-2):89-102. Nakhoul F, Kayne LH, Brautbar N, Hu MS, McDonough A, Eggena P, Golub MS, Berger M, Chang CT, Jamgotchian N, et al. PMID: 1542888.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsPHPublic Health
    144. Hypokalemia decreases Na(+)-K(+)-ATPase alpha 2- but not alpha 1-isoform abundance in heart, muscle, and brain. Am J Physiol. 1991 May; 260(5 Pt 1):C958-64. Azuma KK, Hensley CB, Putnam DS, McDonough AA. PMID: 1852110.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    145. Regulation of testicular P-450 cholesterol side-chain cleavage and P-450 C17-20 lyase/C17 hydroxylase enzymes in the neonatal and adult rat. Acta Endocrinol (Copenh). 1991 Apr; 124(4):449-54. Lu Y, McDonough A, Farley RA, Warren DW. PMID: 2031442.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    146. Low K+ increases Na,K-ATPase abundance in LLC-PK1/Cl4 cells by differentially increasing beta, and not alpha, subunit mRNA. J Biol Chem. 1990 Oct 15; 265(29):17935-40. Lescale-Matys L, Hensley CB, Crnkovic-Markovic R, Putnam DS, McDonough AA. PMID: 2170401.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    147. Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone. J Biol Chem. 1990 Aug 25; 265(24):14308-14. Horowitz B, Hensley CB, Quintero M, Azuma KK, Putnam D, McDonough AA. PMID: 2167313.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    148. Ionic regulation of the biosynthesis of NaK-ATPase subunits. Semin Nephrol. 1990 Jul; 10(4):400-9. McDonough AA, Tang MJ, Lescale-Matys L. PMID: 2166328.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    149. The sodium pump needs its beta subunit. FASEB J. 1990 Apr 01; 4(6):1598-605. McDonough AA, Geering K, Farley RA. PMID: 2156741.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    150. alar4, a constitutive mutant of the A system for amino acid transport, has increased abundance of the Na+,K+-ATPase and mRNA for alpha 1 subunit of this enzyme. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7984-8. Qian NX, Jones M, McDonough A, Englesberg E. PMID: 2554299; PMCID: PMC298197.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    151. Thyroid hormone regulates alpha and alpha + isoforms of Na,K-ATPase during development in neonatal rat brain. J Biol Chem. 1988 Nov 25; 263(33):17643-9. Schmitt CA, McDonough AA. PMID: 2846574.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    152. Patterns of mRNA expression during early cell growth differ in kidney epithelial cells destined to undergo compensatory hypertrophy versus regenerative hyperplasia. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6768-72. Norman JT, Bohman RE, Fischmann G, Bowen JW, McDonough A, Slamon D, Fine LG. PMID: 3413124; PMCID: PMC282059.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    153. Thyroid hormone coordinately regulates Na+-K+-ATPase alpha- and beta-subunit mRNA levels in kidney. Am J Physiol. 1988 Feb; 254(2 Pt 1):C323-9. McDonough AA, Brown TA, Horowitz B, Chiu R, Schlotterbeck J, Bowen J, Schmitt CA. PMID: 2831727.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    154. Isozymes of dog heart Na+-K+-ATPase are immunologically similar to isozymes in brain. Am J Physiol. 1987 Dec; 253(6 Pt 1):C862-5. McDonough AA, Schmitt CA. PMID: 2827499.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    155. Enrichment of Na+-Ca2+ exchange in cardiac sarcolemmal vesicles by alkaline extraction. Biochim Biophys Acta. 1987 May 12; 899(1):59-66. Philipson KD, McDonough AA, Frank JS, Ward R. PMID: 3567192.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    156. Molecular cloning and sequence analysis of the (Na+ + K+)-ATPase beta subunit from dog kidney. Biochim Biophys Acta. 1987 Apr 08; 912(2):244-53. Brown TA, Horowitz B, Miller RP, McDonough AA, Farley RA. PMID: 3030434.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    157. Pretranslational regulation of Na-K-ATPase in cultured canine kidney cells by low K+. Am J Physiol. 1987 Feb; 252(2 Pt 1):C179-89. Bowen JW, McDonough A. PMID: 3030119.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    158. Developmental and thyroid hormone regulation of two molecular forms of Na+-K+-ATPase in brain. J Biol Chem. 1986 Aug 05; 261(22):10439-44. Schmitt CA, McDonough AA. PMID: 3015931.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    159. Isolation of partial cDNAs for rat liver and muscle glycogen phosphorylase isozymes. FEBS Lett. 1986 Jul 07; 202(2):282-8. Osawa S, Chiu RH, McDonough A, Miller TB, Johnson GL. PMID: 2424788.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    160. Mapping subcellular distribution of Na+-K+-ATPase in rat parotid gland. Am J Physiol. 1986 Mar; 250(3 Pt 1):C430-41. Conteas CN, McDonough AA, Kozlowski TR, Hensley CB, Wood RL, Mircheff AK. PMID: 3006505.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    161. Immunodetection of Na,K-ATPase in guinea-pig retinal layers, cornea and lens. Exp Eye Res. 1985 May; 40(5):667-74. McDonough A. PMID: 2988990.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    162. Comparison of subunits of cardiac, brain, and kidney Na+-K+-ATPase. Am J Physiol. 1985 Mar; 248(3 Pt 1):C247-51. McDonough A, Schmitt C. PMID: 2983564.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    163. Assembly of the (Na+ + K+)-adenosine triphosphatase. Post-translational membrane integration of the alpha subunit. J Biol Chem. 1984 Feb 25; 259(4):2629-35. Hiatt A, McDonough AA, Edelman IS. PMID: 6199349.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    164. Characteristics of antibodies to guinea pig (Na+ + K+)-adenosine triphosphatase and their use in cell-free synthesis studies. J Membr Biol. 1982; 69(1):13-22. McDonough AA, Hiatt A, Edelman IS. PMID: 6288956.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    165. Hana kai ii: a 17-day dry saturation dive at 18.6 ATA. III. Body fluid balance. Undersea Biomed Res. 1977 Sep; 4(3):247-65. Hong SK, Claybaugh JR, Frattali V, Johnson R, Kurata F, Matsuda M, McDonough AA, Paganelli CV, Smith RM, Webb P. PMID: 910316.
      View in: PubMed   Mentions: 3     Fields:    
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