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    Alicia A. McDonough, PhD

    TitleProfessor of Cell & Neurobiology
    SchoolKeck School of Medicine of USC
    DepartmentIntegrative Anatomical Sciences
    AddressMMR 508 1333 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90089
    Phone+1 323 442 1238
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McDonough A, Youn JH. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 Mar; 32(2):100-111. PMID: 28202621.
        View in: PubMed
      2. McDonough A, Veiras LC, Guevara CA, Ralph DL. Cardiovascular benefits associated with higher dietary K+ versus lower dietary Na+: Evidence from population and mechanistic studies. Am J Physiol Endocrinol Metab. 2017 Feb 07; ajpendo.00453.2016. PMID: 28174181.
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      3. Chu PL, Gigliotti JC, Cechova S, Bodonyi-Kovacs G, Chan F, Ralph DL, Howell N, Kalantari K, Klibanov AL, Carey RM, McDonough A, Le TH. Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II. J Am Soc Nephrol. 2017 Jan 06. PMID: 28062568.
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      4. Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough A, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA. Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity. Kidney Int. 2016 Dec 14. PMID: 27988209.
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      5. Veiras LC, Han J, Ralph DL, McDonough A. Potassium Supplementation Prevents Sodium Chloride Cotransporter Stimulation During Angiotensin II Hypertension. Hypertension. 2016 Oct; 68(4):904-12. PMID: 27600183.
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      6. McDonough A. ISN Forefronts Symposium 2015: Maintaining Balance Under Pressure-Hypertension and the Proximal Tubule. KI Rep. 2016 Sep; 1(3):166-176. PMID: 27840855.
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      7. Pei L, Solis G, Nguyen MT, Kamat N, Magenheimer L, Zhuo M, Li J, Curry J, McDonough A, Fields TA, Welch WJ, Yu AS. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016 Jul 1; 126(7):2509-18. PMID: 27214555.
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      8. Norlander AE, Saleh MA, Kamat NV, Ko B, Gnecco J, Zhu L, Dale BL, Iwakura Y, Hoover RS, McDonough A, Madhur MS. Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension. 2016 Jul; 68(1):167-74. PMID: 27141060.
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      9. Zhang J, Rudemiller NP, Patel MB, Karlovich NS, Wu M, McDonough A, Griffiths R, Sparks MA, Jeffs AD, Crowley SD. Interleukin-1 Receptor Activation Potentiates Salt Reabsorption in Angiotensin II-Induced Hypertension via the NKCC2 Co-transporter in the Nephron. Cell Metab. 2016 Feb 9; 23(2):360-8. PMID: 26712462.
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      10. Farah LX, Valentini V, Pessoa TD, Malnic G, McDonough A, Girardi AC. The physiological role of glucagon-like peptide-1 in the regulation of renal function. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F123-7. PMID: 26447224.
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      11. Nguyen MT, Han J, Ralph DL, Veiras LC, McDonough A. Short-term nonpressor angiotensin II infusion stimulates sodium transporters in proximal tubule and distal nephron. Physiol Rep. 2015 Sep; 3(9). PMID: 26347505.
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      12. Carneiro de Morais CP, Polidoro JZ, Ralph DL, Pessoa TD, Oliveira-Souza M, Barauna VG, Rebouças NA, Malnic G, McDonough A, Girardi AC. Proximal tubule NHE3 activity is inhibited by beta-arrestin-biased angiotensin II type 1 receptor signaling. Am J Physiol Cell Physiol. 2015 Oct 15; 309(8):C541-50. PMID: 26246427.
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      13. Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough A, Gonzalez-Villalobos RA. Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme. Hypertension. 2015 Sep; 66(3):534-42. PMID: 26150439.
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      14. McDonough A, Nguyen MT. Maintaining Balance Under Pressure: Integrated Regulation of Renal Transporters During Hypertension. Hypertension. 2015 Sep; 66(3):450-5. PMID: 26101347.
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      15. West CA, McDonough A, Masilamani SM, Verlander JW, Baylis C. The renal sodium chloride co-transporter, NCC, is unchanged in the mid pregnant rat and decreased in the late pregnant rat despite avid renal sodium retention. Am J Physiol Renal Physiol. 2015 Apr 29; ajprenal.00147.2015. PMID: 25925254.
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      16. Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough A, Gonzalez-Villalobos RA, Bernstein KE. The intrarenal generation of angiotensin II is required for experimental hypertension. Curr Opin Pharmacol. 2015 Apr; 21:73-81. PMID: 25616034.
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      17. Kamat NV, Thabet SR, Xiao L, Saleh MA, Kirabo A, Madhur MS, Delpire E, Harrison DG, McDonough A. Renal transporter activation during angiotensin-II hypertension is blunted in interferon-?-/- and interleukin-17A-/- mice. Hypertension. 2015 Mar; 65(3):569-76. PMID: 25601932.
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      18. McDonough A, Veiras LC, Minas JN, Ralph DL. Considerations when quantitating protein abundance by immunoblot. Am J Physiol Cell Physiol. 2015 Mar 15; 308(6):C426-33. PMID: 25540176.
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      19. Arystarkhova E, Ralph DL, Liu YB, Bouley R, McDonough A, Sweadner KJ. Paradoxical activation of the sodium chloride cotransporter (NCC) without hypertension in kidney deficient in a regulatory subunit of Na,K-ATPase, FXYD2. Physiol Rep. 2014 Dec 1; 2(12). PMID: 25472608.
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      20. Brasen JC, Burford JL, McDonough A, Holstein-Rathlou NH, Peti-Peterdi J. Local pH domains regulate NHE3-mediated Na? reabsorption in the renal proximal tubule. Am J Physiol Renal Physiol. 2014 Dec 1; 307(11):F1249-62. PMID: 25298526.
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      21. Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough A, Bernstein KE, Gonzalez-Villalobos RA. Renal generation of angiotensin II and the pathogenesis of hypertension. Curr Hypertens Rep. 2014 Sep; 16(9):477. PMID: 25097114.
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      22. Patel HH, McDonough A. Of mice and men: modeling cardiovascular complexity in diabetes. Focus on "Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart". Am J Physiol Cell Physiol. 2014 Sep 15; 307(6):C497-8. PMID: 25031018.
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      23. Giani JF, Janjulia T, Kamat N, Seth DM, Blackwell WL, Shah KH, Shen XZ, Fuchs S, Delpire E, Toblli JE, Bernstein KE, McDonough A, Gonzalez-Villalobos RA. Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition. J Am Soc Nephrol. 2014 Dec; 25(12):2752-63. PMID: 25012170.
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      24. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough A. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May; 306(9):F1059-68. PMID: 24598799.
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      25. Nguyen MT, Lee DH, Delpire E, McDonough A. Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition. Am J Physiol Renal Physiol. 2013 Aug 15; 305(4):F510-9. PMID: 23720346.
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      26. McDonough A, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. PMID: 23633048.
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      27. Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, Giani JF, Nguyen MT, Riquier-Brison AD, Seth DM, Fuchs S, Eladari D, Picard N, Bachmann S, Delpire E, Peti-Peterdi J, Navar LG, Bernstein KE, McDonough A. The absence of intrarenal ACE protects against hypertension. J Clin Invest. 2013 May; 123(5):2011-23. PMID: 23619363.
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      28. Li HC, Du Z, Barone S, Rubera I, McDonough A, Tauc M, Zahedi K, Wang T, Soleimani M. Proximal tubule specific knockout of the Na?/H? exchanger NHE3: effects on bicarbonate absorption and ammonium excretion. J Mol Med (Berl). 2013 Aug; 91(8):951-63. PMID: 23508938.
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      29. Lee DH, Maunsbach AB, Riquier-Brison AD, Nguyen MT, Fenton RA, Bachmann S, Yu AS, McDonough A. Effects of ACE inhibition and ANG II stimulation on renal Na-Cl cotransporter distribution, phosphorylation, and membrane complex properties. Am J Physiol Cell Physiol. 2013 Jan 15; 304(2):C147-63. PMID: 23114965.
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      30. McDonough A, Nguyen MT. How does potassium supplementation lower blood pressure? Am J Physiol Renal Physiol. 2012 May; 302(9):F1224-5. PMID: 22550158.
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      31. Nguyen MT, Yang LE, Fletcher NK, Lee DH, Kocinsky H, Bachmann S, Delpire E, McDonough A. Effects of K+-deficient diets with and without NaCl supplementation on Na+, K+, and H2O transporters' abundance along the nephron. Am J Physiol Renal Physiol. 2012 Jul; 303(1):F92-F104. PMID: 22496411.
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      32. Avner ED, McDonough A, Sweeney WE. Transport, cilia, and PKD: must we in (cyst) on interrelationships? Focus on "Increased Na+/H+ exchanger activity on the apical surface of a cilium-deficient cortical collecting duct principal cell model of polycystic kidney disease". Am J Physiol Cell Physiol. 2012 May 15; 302(10):C1434-5. PMID: 22403786.
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      33. Gurley SB, Riquier-Brison AD, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough A, Koller BH, Coffman TM. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 6; 13(4):469-75. PMID: 21459331.
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      34. McDonough A. Mechanisms of proximal tubule sodium transport regulation that link extracellular fluid volume and blood pressure. Am J Physiol Regul Integr Comp Physiol. 2010 Apr; 298(4):R851-61. PMID: 20106993.
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      35. Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, McDonough A. Angiotensin II stimulates trafficking of NHE3, NaPi2, and associated proteins into the proximal tubule microvilli. Am J Physiol Renal Physiol. 2010 Jan; 298(1):F177-86. PMID: 19864301.
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      36. McDonough A. Motoring down the microvilli. Focus on "PTH-induced internalization of apical membrane NaPi2a: role of actin and myosin VI". Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1331-2. PMID: 19776391.
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      37. Hauck C, Potter T, Bartz M, Wittwer T, Wahlers T, Mehlhorn U, Scheiner-Bobis G, McDonough A, Bloch W, Schwinger RH, Müller-Ehmsen J. Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1. Eur J Pharmacol. 2009 Nov 10; 622(1-3):7-14. PMID: 19751721.
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      38. Greenlee M, Wingo CS, McDonough A, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 5; 150(9):619-25. PMID: 19414841.
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      39. Riquier AD, Lee DH, McDonough A. Renal NHE3 and NaPi2 partition into distinct membrane domains. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C900-10. PMID: 19158399.
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      40. Lee DH, Riquier AD, Yang LE, Leong PK, Maunsbach AB, McDonough A. Acute hypertension provokes acute trafficking of distal tubule Na-Cl cotransporter (NCC) to subapical cytoplasmic vesicles. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F810-8. PMID: 19144688.
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      41. Youn JH, McDonough A. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. PMID: 18759636.
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      42. Yang LE, Sandberg MB, Can AD, Pihakaski-Maunsbach K, McDonough A. Effects of dietary salt on renal Na+ transporter subcellular distribution, abundance, and phosphorylation status. Am J Physiol Renal Physiol. 2008 Oct; 295(4):F1003-16. PMID: 18653479.
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      43. Hanner F, Schnichels M, Zheng-Fischhöfer Q, Yang LE, Toma I, Willecke K, McDonough A, Peti-Peterdi J. Connexin 30.3 is expressed in the kidney but not regulated by dietary salt or high blood pressure. Cell Commun Adhes. 2008 May; 15(1):219-30. PMID: 18649192.
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      44. Petrovic S, Barone S, Wang Z, McDonough A, Amlal H, Soleimani M. Slc26a6 (PAT1) deletion downregulates the apical Na+/H+ exchanger in the straight segment of the proximal tubule. Am J Nephrol. 2008; 28(2):330-8. PMID: 18046080.
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      45. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough A. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. PMID: 18003746.
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      46. Yang LE, Leong PK, McDonough A. Reducing blood pressure in SHR with enalapril provokes redistribution of NHE3, NaPi2, and NCC and decreases NaPi2 and ACE abundance. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1197-208. PMID: 17652375.
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      47. Lee FN, Oh G, McDonough A, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. PMID: 17522262.
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      48. Sandberg MB, Riquier AD, Pihakaski-Maunsbach K, McDonough A, Maunsbach AB. ANG II provokes acute trafficking of distal tubule Na+-Cl(-) cotransporter to apical membrane. Am J Physiol Renal Physiol. 2007 Sep; 293(3):F662-9. PMID: 17507603.
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      49. Elitsur N, Lorenz JN, Hawkins JA, Rudolph JA, Witte D, Yang LE, McDonough A, Cohen MB. The proximal convoluted tubule is a target for the uroguanylin-regulated natriuretic response. J Pediatr Gastroenterol Nutr. 2006 Jul; 43 Suppl 1:S74-81. PMID: 16819406.
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      50. Sandberg MB, Maunsbach AB, McDonough A. Redistribution of distal tubule Na+-Cl- cotransporter (NCC) in response to a high-salt diet. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F503-8. PMID: 16554416.
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      51. Leong PK, Yang LE, Landon CS, McDonough A, Yip KP. Phenol injury-induced hypertension stimulates proximal tubule Na+/H+ exchanger activity. Am J Physiol Renal Physiol. 2006 Jun; 290(6):F1543-50. PMID: 16390865.
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      52. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough A. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. PMID: 16354756.
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      53. Leong PK, Devillez A, Sandberg MB, Yang LE, Yip DK, Klein JB, McDonough A. Effects of ACE inhibition on proximal tubule sodium transport. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F854-63. PMID: 16263808.
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      54. McDonough A, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. PMID: 16139689.
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      55. Yang LE, Maunsbach AB, Leong PK, McDonough A. Redistribution of myosin VI from top to base of proximal tubule microvilli during acute hypertension. J Am Soc Nephrol. 2005 Oct; 16(10):2890-6. PMID: 16107581.
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      56. Yang LE, Maunsbach AB, Leong PK, McDonough A. Differential traffic of proximal tubule Na+ transporters during hypertension or PTH: NHE3 to base of microvilli vs. NaPi2 to endosomes. Am J Physiol Renal Physiol. 2004 Nov; 287(5):F896-906. PMID: 15265767.
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      57. Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough A. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. PMID: 15213056.
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      58. Leong PK, Yang LE, Lin HW, Holstein-Rathlou NH, McDonough A. Acute hypotension induced by aortic clamp vs. PTH provokes distinct proximal tubule Na+ transporter redistribution patterns. Am J Physiol Regul Integr Comp Physiol. 2004 Oct; 287(4):R878-85. PMID: 15205183.
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      59. McDonough A, Biemesderfer D. Does membrane trafficking play a role in regulating the sodium/hydrogen exchanger isoform 3 in the proximal tubule? Curr Opin Nephrol Hypertens. 2003 Sep; 12(5):533-41. PMID: 12920402.
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      60. McDonough A, Leong PK, Yang LE. Mechanisms of pressure natriuresis: how blood pressure regulates renal sodium transport. Ann N Y Acad Sci. 2003 Apr; 986:669-77. PMID: 12763917.
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      61. Yang LE, Leong PK, Guzman JP, Rhee MS, McDonough A. Modest K+ restriction provokes insulin resistance of cellular K+ uptake without decrease in plasma K. Ann N Y Acad Sci. 2003 Apr; 986:625-7. PMID: 12763903.
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      62. Yang LE, Zhong H, Leong PK, Perianayagam A, Campese VM, McDonough A. Chronic renal injury-induced hypertension alters renal NHE3 distribution and abundance. Am J Physiol Renal Physiol. 2003 May; 284(5):F1056-65. PMID: 12554635.
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      63. Leong PK, Yang LE, Holstein-Rathlou NH, McDonough A. Angiotensin II clamp prevents the second step in renal apical NHE3 internalization during acute hypertension. Am J Physiol Renal Physiol. 2002 Nov; 283(5):F1142-50. PMID: 12372791.
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      64. Leong PK, Zhang Y, Yang LE, Holstein-Rathlou NH, McDonough A. Diuretic response to acute hypertension is blunted during angiotensin II clamp. Am J Physiol Regul Integr Comp Physiol. 2002 Oct; 283(4):R837-42. PMID: 12228052.
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      65. Yang LE, Leong PK, Ye S, Campese VM, McDonough A. Responses of proximal tubule sodium transporters to acute injury-induced hypertension. Am J Physiol Renal Physiol. 2003 Feb; 284(2):F313-22. PMID: 12388425.
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      66. McDonough A, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. PMID: 11997312.
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      67. Choi CS, Lee FN, McDonough A, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. PMID: 11916907.
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      68. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough A. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
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      69. Müller-Ehmsen J, McDonough A, Farley RA, Schwinger RH. Sodium pump isoform expression in heart failure: implication for treatment. Basic Res Cardiol. 2002; 97 Suppl 1:I25-30. PMID: 12479230.
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      70. McDonough A, Velotta JB, Schwinger RH, Philipson KD, Farley RA. The cardiac sodium pump: structure and function. Basic Res Cardiol. 2002; 97 Suppl 1:I19-24. PMID: 12479229.
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      71. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough A. Downstream shift in sodium pump activity along the nephron during acute hypertension. J Am Soc Nephrol. 2001 Nov; 12(11):2231-40. PMID: 11675399.
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      72. Müller-Ehmsen J, Juvvadi P, Thompson CB, Tumyan L, Croyle M, Lingrel JB, Schwinger RH, McDonough A, Farley RA. Ouabain and substrate affinities of human Na(+)-K(+)-ATPase alpha(1)beta(1), alpha(2)beta(1), and alpha(3)beta(1) when expressed separately in yeast cells. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1355-64. PMID: 11546674.
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      73. Wang J, Velotta JB, McDonough A, Farley RA. All human Na(+)-K(+)-ATPase alpha-subunit isoforms have a similar affinity for cardiac glycosides. Am J Physiol Cell Physiol. 2001 Oct; 281(4):C1336-43. PMID: 11546672.
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      74. Duchesne R, Klein JD, Velotta JB, Doran JJ, Rouillard P, Roberts BR, McDonough A, Sands JM. UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure. Circ Res. 2001 Jul 20; 89(2):139-45. PMID: 11463720.
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      75. Müller-Ehmsen J, Wang J, Schwinger RH, McDonough A. Region specific regulation of sodium pump isoform and Na,Ca-exchanger expression in the failing human heart--right atrium vs left ventricle. Cell Mol Biol (Noisy-le-grand). 2001 Mar; 47(2):373-81. PMID: 11357898.
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      76. Thompson CB, Dorup I, Ahn J, Leong PK, McDonough A. Glucocorticoids increase sodium pump alpha(2)- and beta(1)-subunit abundance and mRNA in rat skeletal muscle. Am J Physiol Cell Physiol. 2001 Mar; 280(3):C509-16. PMID: 11171570.
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      77. Choi CS, Thompson CB, Leong PK, McDonough A, Youn JH. Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. PMID: 11133519.
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      78. Magyar CE, Zhang Y, Holstein-Rathlou NH, McDonough A. Proximal tubule Na transporter responses are the same during acute and chronic hypertension. Am J Physiol Renal Physiol. 2000 Aug; 279(2):F358-69. PMID: 10919857.
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      79. Nakhoul F, Thompson CB, McDonough A. Developmental change in Na,K-ATPase alpha1 and beta1 expression in normal and hypothyroid rat renal cortex. Am J Nephrol. 2000 May-Jun; 20(3):225-31. PMID: 10878407.
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      80. Magyar CE, McDonough A. Molecular mechanisms of sodium transport inhibition in proximal tubule during acute hypertension. Curr Opin Nephrol Hypertens. 2000 Mar; 9(2):149-56. PMID: 10757220.
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      81. Thompson CB, Choi C, Youn JH, McDonough A. Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 Jun; 276(6 Pt 1):C1411-9. PMID: 10362605.
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      82. Zhang Y, Norian JM, Magyar CE, Holstein-Rathlou NH, Mircheff AK, McDonough A. In vivo PTH provokes apical NHE3 and NaPi2 redistribution and Na-K-ATPase inhibition. Am J Physiol. 1999 May; 276(5 Pt 2):F711-9. PMID: 10330053.
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      83. Schwinger RH, Wang J, Frank K, Müller-Ehmsen J, Brixius K, McDonough A, Erdmann E. Reduced sodium pump alpha1, alpha3, and beta1-isoform protein levels and Na+,K+-ATPase activity but unchanged Na+-Ca2+ exchanger protein levels in human heart failure. Circulation. 1999 Apr 27; 99(16):2105-12. PMID: 10217649.
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      84. McDonough A. Can ENaC regulate ICF as well as ECF volume? Focus on "osmotic pressure regulates alpha beta gamma-rENaC expressed in Xenopus oocytes". Am J Physiol. 1998 Nov; 275(5 Pt 1):C1179-81. PMID: 9814963.
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      85. Yip KP, Tse CM, McDonough A, Marsh DJ. Redistribution of Na+/H+ exchanger isoform NHE3 in proximal tubules induced by acute and chronic hypertension. Am J Physiol. 1998 Oct; 275(4 Pt 2):F565-75. PMID: 9755128.
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      86. Zhang Y, Magyar CE, Norian JM, Holstein-Rathlou NH, Mircheff AK, McDonough A. Reversible effects of acute hypertension on proximal tubule sodium transporters. Am J Physiol. 1998 Apr; 274(4 Pt 1):C1090-100. PMID: 9575807.
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      87. Zhang YB, Magyar CE, Holstein-Rathlou NH, McDonough A. The cytochrome P-450 inhibitor cobalt chloride prevents inhibition of renal Na,K-ATPase and redistribution of apical NHE-3 during acute hypertension. J Am Soc Nephrol. 1998 Apr; 9(4):531-7. PMID: 9555654.
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      88. Guillery EN, Huss DJ, McDonough A, Klein LC. Posttranscriptional upregulation of Na(+)-K(+)-ATPase activity in newborn guinea pig renal cortex. Am J Physiol. 1997 Aug; 273(2 Pt 2):F254-63. PMID: 9277586.
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      89. Thompson CB, McDonough A. Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem. 1996 Dec 20; 271(51):32653-8. PMID: 8955095.
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      90. Wang J, Schwinger RH, Frank K, Müller-Ehmsen J, Martin-Vasallo P, Pressley TA, Xiang A, Erdmann E, McDonough A. Regional expression of sodium pump subunits isoforms and Na+-Ca++ exchanger in the human heart. J Clin Invest. 1996 Oct 1; 98(7):1650-8. PMID: 8833915.
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      91. Zhang Y, Mircheff AK, Hensley CB, Magyar CE, Warnock DG, Chambrey R, Yip KP, Marsh DJ, Holstein-Rathlou NH, McDonough A. Rapid redistribution and inhibition of renal sodium transporters during acute pressure natriuresis. Am J Physiol. 1996 Jun; 270(6 Pt 2):F1004-14. PMID: 8764320.
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      92. McDonough A, Zhang Y, Shin V, Frank JS. Subcellular distribution of sodium pump isoform subunits in mammalian cardiac myocytes. Am J Physiol. 1996 Apr; 270(4 Pt 1):C1221-7. PMID: 8928749.
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      93. McDonough A, Thompson CB. Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation. Acta Physiol Scand. 1996 Mar; 156(3):295-304. PMID: 8729690.
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      96. McDonough A, Wang J, Farley RA. Significance of sodium pump isoforms in digitalis therapy. J Mol Cell Cardiol. 1995 Apr; 27(4):1001-9. PMID: 7563097.
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      98. Hensley CB, Bersohn MM, Sarma JS, Singh BN, McDonough A. Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle. J Mol Cell Cardiol. 1994 Apr; 26(4):417-24. PMID: 8071999.
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      99. Wang L, McComb JG, Weiss MH, McDonough A, Zlokovic BV. Nicotine downregulates alpha 2 isoform of Na,K-ATPase at the blood-brain barrier and brain in rats. Biochem Biophys Res Commun. 1994 Mar 30; 199(3):1422-7. PMID: 8147886.
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      100. Bradley ME, Azuma KK, McDonough A, Mircheff AK, Wood RL. Surface and intracellular pools of Na,K-ATPase catalytic and immuno-activities in rat exorbital lacrimal gland. Exp Eye Res. 1993 Oct; 57(4):403-13. PMID: 8282026.
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      101. Lescale-Matys L, Putnam DS, McDonough A. Surplus Na+ pumps: how low-K(+)-incubated LLC-PK1 cells respond to K+ restoration. Am J Physiol. 1993 Oct; 265(4 Pt 1):C887-92. PMID: 8238313.
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      102. Azuma KK, Hensley CB, Tang MJ, McDonough A. Thyroid hormone specifically regulates skeletal muscle Na(+)-K(+)-ATPase alpha 2- and beta 2-isoforms. Am J Physiol. 1993 Sep; 265(3 Pt 1):C680-7. PMID: 8214025.
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      103. McDonough A, Farley RA. Regulation of Na,K-ATPase activity. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):725-34. PMID: 7922215.
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      104. Lescale-Matys L, Putnam DS, McDonough A. Na(+)-K(+)-ATPase alpha 1- and beta 1-subunit degradation: evidence for multiple subunit specific rates. Am J Physiol. 1993 Mar; 264(3 Pt 1):C583-90. PMID: 8384785.
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      105. McDonough A, Azuma KK, Lescale-Matys L, Tang MJ, Nakhoul F, Hensley CB, Komatsu Y. Physiologic rationale for multiple sodium pump isoforms. Differential regulation of alpha 1 vs alpha 2 by ionic stimuli. Ann N Y Acad Sci. 1992 Nov 30; 671:156-68; discussion 168-9. PMID: 1337670.
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      106. Tang MJ, McDonough A. Low K+ increases Na(+)-K(+)-ATPase alpha- and beta-subunit mRNA and protein abundance in cultured renal proximal tubule cells. Am J Physiol. 1992 Aug; 263(2 Pt 1):C436-42. PMID: 1381148.
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      107. Hensley CB, Azuma KK, Tang MJ, McDonough A. Thyroid hormone induction of rat myocardial Na(+)-K(+)-ATPase: alpha 1-, alpha 2-, and beta 1-mRNA and -protein levels at steady state. Am J Physiol. 1992 Feb; 262(2 Pt 1):C484-92. PMID: 1311504.
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      108. Mircheff AK, Bowen JW, Yiu SC, McDonough A. Synthesis and translocation of Na(+)-K(+)-ATPase alpha- and beta-subunits to plasma membrane in MDCK cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C470-83. PMID: 1311503.
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      109. McDonough A, Hensley CB, Azuma KK. Differential regulation of sodium pump isoforms in heart. Semin Nephrol. 1992 Jan; 12(1):49-55. PMID: 1312744.
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      110. Azuma KK, Hensley CB, Putnam DS, McDonough A. Hypokalemia decreases Na(+)-K(+)-ATPase alpha 2- but not alpha 1-isoform abundance in heart, muscle, and brain. Am J Physiol. 1991 May; 260(5 Pt 1):C958-64. PMID: 1852110.
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      111. Lescale-Matys L, Hensley CB, Crnkovic-Markovic R, Putnam DS, McDonough A. Low K+ increases Na,K-ATPase abundance in LLC-PK1/Cl4 cells by differentially increasing beta, and not alpha, subunit mRNA. J Biol Chem. 1990 Oct 15; 265(29):17935-40. PMID: 2170401.
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      112. Horowitz B, Hensley CB, Quintero M, Azuma KK, Putnam D, McDonough A. Differential regulation of Na,K-ATPase alpha 1, alpha 2, and beta subunit mRNA and protein levels by thyroid hormone. J Biol Chem. 1990 Aug 25; 265(24):14308-14. PMID: 2167313.
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      113. McDonough A, Tang MJ, Lescale-Matys L. Ionic regulation of the biosynthesis of NaK-ATPase subunits. Semin Nephrol. 1990 Jul; 10(4):400-9. PMID: 2166328.
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