Susan Bailey Gurley, MD, PhD

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
Address1537 Norfolk St.
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Chair of the Department of Medicine


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    Collapse Overview
    Dr. Susan Gurley is the Kenneth T. Norris, Jr. Chair of the Department of Medicine. She is a nephrology physician scientist who studies the most common causes of kidney disease: diabetic nephropathy and hypertension. After completing her PhD in biophysical chemistry (University of Mississippi), she obtained her MD at Washington University School of Medicine in St. Louis, MO. She completed her residency in internal medicine and fellowship in nephrology at Duke University School of Medicine, where she began her faculty career. At Duke, she held several leadership roles focused on faculty development and biomedical research. Notably, she was Section Chief, Renal at the Durham VA HCS from2012-2018. In 2018 she was recruited to Oregon Health & Science University (OHSU) to lead the Division of Nephrology & Hypertension and was later named interim chair, Department of Medicine (2021-2023). On August 1, 2023, Dr. Gurley was appointed Chair, Department of Medicine at Keck School of Medicine, University of Southern California.

    Dr. Gurley’s current research program utilizes mouse models of human diseases to study disease
    pathogenesis. She has more than 20 years of experience studying the pathogenesis of hypertension and diabetic nephropathy using transgenic mouse models in renal physiologic studies. Dr. Gurley has extensive knowledge of the renin-angiotensin system (in particular the type 1 angiotensin II receptor and ACE2), including conditional gene targeting in mice, cardiovascular studies in mice, angiotensin peptide metabolism, and genomic and metabolomics analyses. A major focus of her laboratory is on the function of ACE2 in blood pressure regulation and kidney injury.
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    Collapse Research 
    Collapse Research Activities and Funding
    Medical Scientist Training Program of Oregon Health & Science University
    NIH T32GM141938Jul 1, 2021 - Jun 30, 2026
    Role: Co-Principal Investigator
    Actions of Angiotensin II Along the Nephron to Regulate Blood Pressure
    NIH R01DK098382Apr 1, 2014 - Mar 31, 2020
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension. J Am Heart Assoc. 2024 May 21; 13(10):e033998. Becerra Calderon A, Shroff UN, Deepak S, Izuhara A, Trogen G, McDonough AA, Gurley SB, Nelson JW, Peti-Peterdi J, Gyarmati G. PMID: 38726925; PMCID: PMC11179802.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Parental recovered acute kidney injury causes prenatal renal dysfunction and fetal growth restriction with sexually dimorphic implications for adult offspring. Front Physiol. 2024; 15:1357932. Hebert JF, Funahashi Y, Emathinger JM, Nickerson MN, Groat T, Andeen NK, Gurley SB, Hutchens MP. PMID: 38681142; PMCID: PMC11045984.
      View in: PubMed   Mentions:
    3. Kidney Renin-Angiotensin System: Lost in a RAS Cascade. Hypertension. 2024 Apr; 81(4):682-686. Crowley SD, Navar LG, Prieto MC, Gurley SB, Coffman TM. PMID: 38507510; PMCID: PMC10957093.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Characteristics and Outcomes of NELL1 Membranous Nephropathy in Lipoic Acid Users and Nonusers. Kidney Int Rep. 2024 May; 9(5):1379-1386. Avasare RS, Clark S, Spain RI, Wusirika R, Rope R, Gurley S, Stanaway M, Sekulic M, Santoriello D, Bomback AS, Canetta P, Iyer SJ, Kung V, Charu V, Troxell ML, Kudose S, Andeen NK. PMID: 38707817; PMCID: PMC11068956.
      View in: PubMed   Mentions:
    5. Role of Angiotensin II Type 1a Receptor (AT1aR) of Renal Tubules in Regulating Inwardly Rectifying Potassium Channels 4.2 (Kir4.2), Kir4.1, and Epithelial Na+ Channel (ENaC). Hypertension. 2024 Jan; 81(1):126-137. Duan XP, Xiao Y, Su XT, Zheng JY, Gurley S, Emathinger J, Yang CL, McCormick J, Ellison DH, Lin DH, Wang WH. PMID: 37909221; PMCID: PMC10842168.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    6. Hospital at Home meets need for new dialysis patients. Clin Nephrol. 2023 Nov; 100(5):231-234. Smith J, Mayo A, Gurley SB, Wusirika R. PMID: 37779451.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    7. Abnormal lactate metabolism is linked to albuminuria and kidney injury in diabetic nephropathy. Kidney Int. 2023 12; 104(6):1135-1149. Azushima K, Kovalik JP, Yamaji T, Ching J, Chng TW, Guo J, Liu JJ, Nguyen M, Sakban RB, George SE, Tan PH, Lim SC, Gurley SB, Coffman TM. PMID: 37843477.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    8. Increased Risk of Preeclampsia with Assisted Reproductive Technologies. Curr Hypertens Rep. 2023 09; 25(9):251-261. Kornfield MS, Gurley SB, Vrooman LA. PMID: 37303020.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Soluble ACE2 Is Filtered into the Urine. Kidney360. 2022 12 29; 3(12):2086-2094. Nelson JW, Ortiz-Melo DI, Mattocks NK, Emathinger JM, Prescott J, Xu K, Griffiths RC, Wakasaki R, Piehowski PD, Hutchens MP, Coffman TM, Gurley SB. PMID: 36591353; PMCID: PMC9802553.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    10. The Importance of Transplant Nephrology to a Successful Kidney Transplant Program. Clin J Am Soc Nephrol. 2022 09; 17(9):1403-1406. Moe SM, Brennan DC, Doshi MD, Gaston RS, Gurley SB, Mujtaba MA, Schmidt RJ, Segal MS, Tucker JK, Wiseman AC, Josephson MA. PMID: 35914794; PMCID: PMC9625111.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay. Clin J Am Soc Nephrol. 2022 09; 17(9):1407-1409. Josephson MA, Wiseman AC, Tucker JK, Segal MS, Schmidt RJ, Mujtaba MA, Gurley SB, Gaston RS, Doshi MD, Brennan DC, Moe SM. PMID: 35914793; PMCID: PMC9625105.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Chronic activation of vasopressin-2 receptors induces hypertension in Liddle mice by promoting Na+ and water retention. Am J Physiol Renal Physiol. 2022 10 01; 323(4):F468-F478. Stockand JD, Mironova EV, Xiang H, Soares AG, Contreras J, McCormick JA, Gurley SB, Pao AC. PMID: 35900342; PMCID: PMC9485005.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    13. Fibrillary Glomerulonephritis, DNAJB9, and the Unfolded Protein Response. Glomerular Dis. 2022; 2(4):164-175. Andeen NK, Kung VL, Robertson J, Gurley SB, Avasare RS, Sitaraman S. PMID: 36817290; PMCID: PMC9936766.
      View in: PubMed   Mentions: 3  
    14. Combined Kelch-like 3 and Cullin 3 Degradation is a Central Mechanism in Familial Hyperkalemic Hypertension in Mice. J Am Soc Nephrol. 2022 03; 33(3):584-600. Maeoka Y, Ferdaus MZ, Cornelius RJ, Sharma A, Su XT, Miller LN, Robertson JA, Gurley SB, Yang CL, Ellison DH, McCormick JA. PMID: 35064051; PMCID: PMC8975056.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    15. Local and downstream actions of proximal tubule angiotensin II signaling on Na+ transporters in the mouse nephron. Am J Physiol Renal Physiol. 2021 07 01; 321(1):F69-F81. Nelson JW, McDonough AA, Xiang Z, Ralph DL, Robertson JA, Giani JF, Bernstein KE, Gurley SB. PMID: 34056928; PMCID: PMC8321806.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    16. Vascular control of kidney epithelial transporters. Am J Physiol Renal Physiol. 2021 06 01; 320(6):F1080-F1092. Sparks MA, Dilmen E, Ralph DL, Rianto F, Hoang TA, Hollis A, Diaz EJ, Adhikari R, Chew G, Petretto EG, Gurley SB, McDonough AA, Coffman TM. PMID: 33969697; PMCID: PMC8285646.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Advances in use of mouse models to study the renin-angiotensin system. Mol Cell Endocrinol. 2021 06 01; 529:111255. Emathinger JM, Nelson JW, Gurley SB. PMID: 33789143; PMCID: PMC9119406.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    18. Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. Hypertension. 2021 02; 77(2):393-404. Sparks MA, Rianto F, Diaz E, Revoori R, Hoang T, Bouknight L, Stegbauer J, Vivekanandan-Giri A, Ruiz P, Pennathur S, Abraham DM, Gurley SB, Crowley SD, Coffman TM. PMID: 33390039; PMCID: PMC7803456.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    19. Severe Acute Respiratory Syndrome Coronavirus 2, COVID-19, and the Renin-Angiotensin System: Pressing Needs and Best Research Practices. Hypertension. 2020 11; 76(5):1350-1367. Sparks MA, South AM, Badley AD, Baker-Smith CM, Batlle D, Bozkurt B, Cattaneo R, Crowley SD, Dell'Italia LJ, Ford AL, Griendling K, Gurley SB, Kasner SE, Murray JA, Nath KA, Pfeffer MA, Rangaswami J, Taylor WR, Garovic VD. PMID: 32981369; PMCID: PMC7685174.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansPHPublic Health
    20. Advancing Nephrology: Division Leaders Advise ASN. Clin J Am Soc Nephrol. 2021 02 08; 16(2):319-327. Braden GL, Chapman A, Ellison DH, Gadegbeku CA, Gurley SB, Igarashi P, Kelepouris E, Moxey-Mims MM, Okusa MD, Plumb TJ, Quaggin SE, Salant DJ, Segal MS, Shankland SJ, Somlo S. PMID: 32792352; PMCID: PMC7863658.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    21. Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis. J Am Soc Nephrol. 2020 07; 31(7):1479-1495. Feng D, Kumar M, Muntel J, Gurley SB, Birrane G, Stillman IE, Ding L, Wang M, Ahmed S, Schlondorff J, Alper SL, Ferrante T, Marquez SL, Ng CF, Novak R, Ingber DE, Steen H, Pollak MR. PMID: 32540856; PMCID: PMC7351002.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    22. Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults: A Living Systematic Review. Ann Intern Med. 2020 08 04; 173(3):195-203. Mackey K, King VJ, Gurley S, Kiefer M, Liederbauer E, Vela K, Sonnen P, Kansagara D. PMID: 32422062; PMCID: PMC7249560.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCellsPHPublic Health
    23. α2A-Adrenoceptors Modulate Renal Sympathetic Neurotransmission and Protect against Hypertensive Kidney Disease. J Am Soc Nephrol. 2020 04; 31(4):783-798. Hering L, Rahman M, Hoch H, Markó L, Yang G, Reil A, Yakoub M, Gupta V, Potthoff SA, Vonend O, Ralph DL, Gurley SB, McDonough AA, Rump LC, Stegbauer J. PMID: 32086277; PMCID: PMC7191918.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    24. Electrolyte and transporter responses to angiotensin II induced hypertension in female and male rats and mice. Acta Physiol (Oxf). 2020 05; 229(1):e13448. Veiras LC, McFarlin BE, Ralph DL, Buncha V, Prescott J, Shirvani BS, McDonough JC, Ha D, Giani J, Gurley SB, Mamenko M, McDonough AA. PMID: 31994810; PMCID: PMC7156336.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    25. DNAJB9 Is Not Transcriptionally Upregulated in the Glomerulus in Fibrillary Glomerulonephritis. Kidney Int Rep. 2020 Mar; 5(3):368-372. Avasare RS, Robinson BA, Nelson J, Woltjer R, Krajbich V, Nguyen V, Garcia D, Setthavongsack N, Kizzar C, Raess PW, Gurley SB, Smith KD, Andeen NK. PMID: 32154459; PMCID: PMC7056856.
      View in: PubMed   Mentions: 5  
    26. Adipocyte deficiency of ACE2 increases systolic blood pressures of obese female C57BL/6 mice. Biol Sex Differ. 2019 09 04; 10(1):45. Shoemaker R, Tannock LR, Su W, Gong M, Gurley SB, Thatcher SE, Yiannikouris F, Ensor CM, Cassis LA. PMID: 31484552; PMCID: PMC6727421.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    27. Inflammation and Immunity Pathways Regulate Genetic Susceptibility to Diabetic Nephropathy. Diabetes. 2018 10; 67(10):2096-2106. Gurley SB, Ghosh S, Johnson SA, Azushima K, Sakban RB, George SE, Maeda M, Meyer TW, Coffman TM. PMID: 30065034; PMCID: PMC6152345.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    28. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol. 2018 10 18; 25(10):1195-1207.e32. Carlson DA, Singer MR, Sutherland C, Redondo C, Alexander LT, Hughes PF, Knapp S, Gurley SB, Sparks MA, MacDonald JA, Haystead TAJ. PMID: 30033129; PMCID: PMC6863095.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    29. Metabolic Changes with Base-Loading in CKD. Clin J Am Soc Nephrol. 2018 08 07; 13(8):1244-1246. Scialla JJ, Brown L, Gurley S, Corcoran DL, Bain JR, Muehlbauer MJ, O'Neal SK, M O'Connell T, Wolf M, Melamed ML, Hostetter TH, Abramowitz MK. PMID: 29934431; PMCID: PMC6086694.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies. Comput Chem Eng. 2018 Apr 06; 112:253-264. Leete J, Gurley S, Layton A. PMID: 30555192; PMCID: PMC6290907.
      View in: PubMed   Mentions: 16  
    31. Blood pressure regulation by the angiotensin type 1 receptor in the proximal tubule. Curr Opin Nephrol Hypertens. 2018 01; 27(1):1-7. van Haaster MC, McDonough AA, Gurley SB. PMID: 29045337; PMCID: PMC5818672.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy. Am J Physiol Renal Physiol. 2018 04 01; 314(4):F531-F542. Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, Gurley SB, Gonzalez-Villalobos RA, Bernstein KE, Giani JF. PMID: 29187372; PMCID: PMC5966765.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    33. Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells. Cardiovasc Res. 2017 Nov 01; 113(13):1551-1559. Zhang L, Wu JH, Otto JC, Gurley SB, Hauser ER, Shenoy SK, Nagi K, Brian L, Wertman V, Mattocks N, Lawson JH, Freedman NJ. PMID: 29048463; PMCID: PMC5852622.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    34. Modelling diabetic nephropathy in mice. Nat Rev Nephrol. 2018 Jan; 14(1):48-56. Azushima K, Gurley SB, Coffman TM. PMID: 29062142.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    35. Angiotensin receptor signaling and prostate tumor growth in mice. J Exp Ther Oncol. 2017 Sep; 11(2):107-115. Scott-Emuakpor J, Allot E, Johnson SA, Howard LE, Macias E, Freedland SJ, Gurley SB. PMID: 28976133; PMCID: PMC6311706.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    36. Photoacoustic imaging for in vivo quantification of placental oxygenation in mice. FASEB J. 2017 12; 31(12):5520-5529. Yamaleyeva LM, Sun Y, Bledsoe T, Hoke A, Gurley SB, Brosnihan KB. PMID: 28842425; PMCID: PMC5690392.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    37. Resistance to hypertension mediated by intercalated cells of the collecting duct. JCI Insight. 2017 04 06; 2(7):e92720. Stegbauer J, Chen D, Herrera M, Sparks MA, Yang T, Königshausen E, Gurley SB, Coffman TM. PMID: 28405625; PMCID: PMC5374064.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    38. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Sci Rep. 2016 09 21; 6:33678. Domenig O, Manzel A, Grobe N, Königshausen E, Kaltenecker CC, Kovarik JJ, Stegbauer J, Gurley SB, van Oyen D, Antlanger M, Bader M, Motta-Santos D, Santos RA, Elased KM, Säemann MD, Linker RA, Poglitsch M. PMID: 27649628; PMCID: PMC5030486.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimals
    39. Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system. J Hypertens. 2016 09; 34(9):1752-65. Clotet S, Soler MJ, Rebull M, Gimeno J, Gurley SB, Pascual J, Riera M. PMID: 27379538.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    40. A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots. Lab Anim. 2017 Apr; 51(2):138-146. Otaño-Rivera V, Boakye A, Grobe N, Almutairi MM, Kursan S, Mattis LK, Castrop H, Gurley SB, Elased KM, Boivin GP, Di Fulvio M. PMID: 27166392.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    41. Incorporating Geriatric Assessment into a Nephrology Clinic: Preliminary Data from Two Models of Care. J Am Geriatr Soc. 2016 10; 64(10):2154-2158. Hall RK, Haines C, Gorbatkin SM, Schlanger L, Shaban H, Schell JO, Gurley SB, Colón-Emeric CS, Bowling CB. PMID: 27377350; PMCID: PMC5073016.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    42. Impact of Angiotensin Type 1A Receptors in Principal Cells of the Collecting Duct on Blood Pressure and Hypertension. Hypertension. 2016 06; 67(6):1291-7. Chen D, Stegbauer J, Sparks MA, Kohan D, Griffiths R, Herrera M, Gurley SB, Coffman TM. PMID: 27141055; PMCID: PMC4865430.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    43. Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. J Am Soc Nephrol. 2016 08; 27(8):2257-64. Zhang J, Rudemiller NP, Patel MB, Wei Q, Karlovich NS, Jeffs AD, Wu M, Sparks MA, Privratsky JR, Herrera M, Gurley SB, Nedospasov SA, Crowley SD. PMID: 26744488; PMCID: PMC4978052.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    44. Angiotensin converting enzyme 2 and the kidney. Curr Opin Nephrol Hypertens. 2016 Jan; 25(1):59-66. Ortiz-Melo DI, Gurley SB. PMID: 26575394.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    45. Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity. Am J Physiol Endocrinol Metab. 2015 Jul 01; 309(1):E84-94. Yamaleyeva LM, Pulgar VM, Lindsey SH, Yamane L, Varagic J, McGee C, daSilva M, Lopes Bonfa P, Gurley SB, Brosnihan KB. PMID: 25968580; PMCID: PMC4490333.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    46. Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion. J Am Soc Nephrol. 2015 Dec; 26(12):2953-62. Sparks MA, Stegbauer J, Chen D, Gomez JA, Griffiths RC, Azad HA, Herrera M, Gurley SB, Coffman TM. PMID: 25855778; PMCID: PMC4657834.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    47. Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Mol Metab. 2015 Apr; 4(4):337-43. Young CN, Morgan DA, Butler SD, Rahmouni K, Gurley SB, Coffman TM, Mark AL, Davisson RL. PMID: 25830096; PMCID: PMC4354922.
      View in: PubMed   Mentions: 17     Fields:    
    48. The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice. Neurourol Urodyn. 2015 Jan; 34(1):72-8. Dolber PC, Jin H, Nassar R, Coffman TM, Gurley SB, Fraser MO. PMID: 25646557; PMCID: PMC4559278.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    49. Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12):2617-23. Thatcher SE, Zhang X, Howatt DA, Yiannikouris F, Gurley SB, Ennis T, Curci JA, Daugherty A, Cassis LA. PMID: 25301841; PMCID: PMC4250973.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    50. Classical Renin-Angiotensin system in kidney physiology. Compr Physiol. 2014 Jul; 4(3):1201-28. Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM. PMID: 24944035; PMCID: PMC4137912.
      View in: PubMed   Mentions: 234     Fields:    Translation:HumansAnimals
    51. ACE2 deficiency increases NADPH-mediated oxidative stress in the kidney. Physiol Rep. 2014; 2(3):e00264. Wysocki J, Ortiz-Melo DI, Mattocks NK, Xu K, Prescott J, Evora K, Ye M, Sparks MA, Haque SK, Batlle D, Gurley SB. PMID: 24760518; PMCID: PMC4002244.
      View in: PubMed   Mentions: 36     Fields:    
    52. Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells. PLoS One. 2014; 9(1):e85958. Xiao F, Zimpelmann J, Agaybi S, Gurley SB, Puente L, Burns KD. PMID: 24454948; PMCID: PMC3893316.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    53. Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). J Biol Chem. 2013 Aug 23; 288(34):24834-47. Konvalinka A, Zhou J, Dimitromanolakis A, Drabovich AP, Fang F, Gurley S, Coffman T, John R, Zhang SL, Diamandis EP, Scholey JW. PMID: 23846697; PMCID: PMC3750178.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    54. Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice. J Cardiovasc Pharmacol Ther. 2013 Mar; 18(2):138-51. Alghamri MS, Weir NM, Anstadt MP, Elased KM, Gurley SB, Morris M. PMID: 23043153.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    55. Targeting eNOS in pancreatic cancer. Cancer Res. 2012 Sep 01; 72(17):4472-82. Lampson BL, Kendall SD, Ancrile BB, Morrison MM, Shealy MJ, Barrientos KS, Crowe MS, Kashatus DF, White RR, Gurley SB, Cardona DM, Counter CM. PMID: 22738914; PMCID: PMC3749841.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    56. Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. PLoS One. 2012; 7(4):e33942. Chang JH, Paik SY, Mao L, Eisner W, Flannery PJ, Wang L, Tang Y, Mattocks N, Hadjadj S, Goujon JM, Ruiz P, Gurley SB, Spurney RF. PMID: 22496773; PMCID: PMC3319540.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    57. Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress. J Neurosci. 2012 Feb 08; 32(6):2051-61. Chen D, Jancovski N, Bassi JK, Nguyen-Huu TP, Choong YT, Palma-Rigo K, Davern PJ, Gurley SB, Thomas WG, Head GA, Allen AM. PMID: 22323719; PMCID: PMC6621685.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    58. Assessment of diabetic nephropathy in the Akita mouse. Methods Mol Biol. 2012; 933:17-29. Chang JH, Gurley SB. PMID: 22893398.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    59. AT1 receptors in the collecting duct directly modulate the concentration of urine. J Am Soc Nephrol. 2011 Dec; 22(12):2237-46. Stegbauer J, Gurley SB, Sparks MA, Woznowski M, Kohan DE, Yan M, Lehrich RW, Coffman TM. PMID: 22052052; PMCID: PMC3250205.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    60. Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. Hypertension. 2011 Nov; 58(5):852-8. Bharadwaj MS, Strawn WB, Groban L, Yamaleyeva LM, Chappell MC, Horta C, Atkins K, Firmes L, Gurley SB, Brosnihan KB. PMID: 21968754; PMCID: PMC3228834.
      View in: PubMed   Mentions: 39     Fields:    Translation:Animals
    61. ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. PLoS One. 2011; 6(7):e22682. Xia H, Suda S, Bindom S, Feng Y, Gurley SB, Seth D, Navar LG, Lazartigues E. PMID: 21818366; PMCID: PMC3144922.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    62. Minding the gap: connexin 40 at the heart of renin release. J Am Soc Nephrol. 2011 Jun; 22(6):985-6. Facemire CS, Gurley SB. PMID: 21617119.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    63. AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. Cell Metab. 2011 Apr 06; 13(4):469-475. Gurley SB, Riquier-Brison ADM, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM. PMID: 21459331; PMCID: PMC3070917.
      View in: PubMed   Mentions: 141     Fields:    Translation:AnimalsCells
    64. Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):758-65. Thatcher SE, Zhang X, Howatt DA, Lu H, Gurley SB, Daugherty A, Cassis LA. PMID: 21252069; PMCID: PMC3086633.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    65. Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. Hypertension. 2011 Mar; 57(3):577-85. Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffiths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM. PMID: 21242463; PMCID: PMC3077960.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    66. An IRKO in the Podo: impaired insulin signaling in podocytes and the pathogenesis of diabetic nephropathy. Cell Metab. 2010 Oct 06; 12(4):311-312. Gurley SB, Coffman TM. PMID: 20889121.
      View in: PubMed   Mentions: 2     Fields:    
    67. Renal actions of RGS2 control blood pressure. J Am Soc Nephrol. 2010 Nov; 21(11):1847-51. Gurley SB, Griffiths RC, Mendelsohn ME, Karas RH, Coffman TM. PMID: 20847141; PMCID: PMC3013999.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    68. Influence of genetic background on albuminuria and kidney injury in Ins2(+/C96Y) (Akita) mice. Am J Physiol Renal Physiol. 2010 Mar; 298(3):F788-95. Gurley SB, Mach CL, Stegbauer J, Yang J, Snow KP, Hu A, Meyer TW, Coffman TM. PMID: 20042456; PMCID: PMC2838602.
      View in: PubMed   Mentions: 70     Fields:    Translation:Animals
    69. Mouse models of diabetic nephropathy. J Am Soc Nephrol. 2009 Dec; 20(12):2503-12. Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T, Animal Models of Diabetic Complications Consortium. PMID: 19729434; PMCID: PMC4075053.
      View in: PubMed   Mentions: 302     Fields:    Translation:HumansAnimals
    70. Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. Exp Physiol. 2008 May; 93(5):538-42. Gurley SB, Coffman TM. PMID: 18376006.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
    71. The renin-angiotensin system and diabetic nephropathy. Semin Nephrol. 2007 Mar; 27(2):144-52. Gurley SB, Coffman TM. PMID: 17418683.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimals
    72. AT(1) receptors and control of blood pressure: the kidney and more... Trends Cardiovasc Med. 2007 Jan; 17(1):30-4. Crowley SD, Gurley SB, Coffman TM. PMID: 17210476.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    73. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A. 2006 Nov 21; 103(47):17985-90. Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. PMID: 17090678; PMCID: PMC1693859.
      View in: PubMed   Mentions: 340     Fields:    Translation:HumansAnimals
    74. Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. J Clin Invest. 2006 Aug; 116(8):2218-25. Gurley SB, Allred A, Le TH, Griffiths R, Mao L, Philip N, Haystead TA, Donoghue M, Breitbart RE, Acton SL, Rockman HA, Coffman TM. PMID: 16878172; PMCID: PMC1518789.
      View in: PubMed   Mentions: 151     Fields:    Translation:Animals
    75. ACE and ACE2 activity in diabetic mice. Diabetes. 2006 Jul; 55(7):2132-9. Wysocki J, Ye M, Soler MJ, Gurley SB, Xiao HD, Bernstein KE, Coffman TM, Chen S, Batlle D. PMID: 16804085.
      View in: PubMed   Mentions: 166     Fields:    Translation:AnimalsCells
    76. New mass spectrometric assay for angiotensin-converting enzyme 2 activity. Hypertension. 2006 May; 47(5):1010-7. Elased KM, Cunha TS, Gurley SB, Coffman TM, Morris M. PMID: 16585421.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    77. Impact of genetic background on nephropathy in diabetic mice. Am J Physiol Renal Physiol. 2006 Jan; 290(1):F214-22. Gurley SB, Clare SE, Snow KP, Hu A, Meyer TW, Coffman TM. PMID: 16118394.
      View in: PubMed   Mentions: 149     Fields:    Translation:Animals
    78. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. J Clin Invest. 2005 Apr; 115(4):1092-9. Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM. PMID: 15841186; PMCID: PMC1070417.
      View in: PubMed   Mentions: 170     Fields:    Translation:Animals
    79. Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. Cold Spring Harb Symp Quant Biol. 2002; 67:451-7. Gurley SB, Le TH, Coffman TM. PMID: 12858571.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals