Jang-Hyun Youn • USC Profiles

Jang-Hyun Youn, PhD

Title(s)	Associate Professor of Physiology & Neuroscience
School	Keck School of Medicine of Usc
Address	CSC 214, 2250 Alcazar Steet Health Sciences Campus Los Angeles CA 90033
Phone	+1 323 442 3260
vCard	Download vCard

Overview

Websites

Programs in Biomedical and Biological Sciences

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Novel neuropharmacological activity of citrus lime (Citrus aurantifolia): A standardized lime peel supplement enhances non-rapid eye movement sleep by activating the GABA type A receptor. Biomed Pharmacother. 2024 Oct; 179:117410. Kim S, Kim D, Lee J, Han JK, Um MY, Jung JH, Yoon M, Choi Y, Oh Y, Youn JH, Cho S. PMID: 39270541.

View in: PubMed Mentions: Fields:
Bio Biology Dru Drug Therapy Med Medicine (General)
Translation:Animals
Kinetic Modeling of In Vivo K+ Distribution and Fluxes with Stable K+ Isotopes: Effects of Dietary K+ Restriction. Int J Mol Sci. 2024 Sep 06; 25(17). Youn JH, Gili S, Oh Y, McDonough AA, Higgins J. PMID: 39273611; PMCID: PMC11395305.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals
High-Fat Feeding Alters Circulating Triglyceride Composition: Roles of FFA Desaturation and ω-3 Fatty Acid Availability. Int J Mol Sci. 2024 Aug 13; 25(16). Shen T, Oh Y, Jeong S, Cho S, Fiehn O, Youn JH. PMID: 39201497; PMCID: PMC11354557.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals
Determinants of Meal-Induced Changes in Circulating FFA Epoxides, Diols, and Diol-to-Epoxide Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Dec 11; 24(24). Oh YT, Yang J, Stefanovski D, Hammock B, Youn JH. PMID: 38139180; PMCID: PMC10743433.

View in: PubMed Mentions: Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Humans Animals
Effects of Individual Circulating FFAs on Plasma and Hepatic FFA Epoxides, Diols, and Epoxide-Diol Ratios as Indices of Soluble Epoxide Hydrolase Activity. Int J Mol Sci. 2023 Jun 28; 24(13). Oh YT, Yang J, Morisseau C, He Q, Hammock B, Youn JH. PMID: 37445935; PMCID: PMC10341844.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Che Chemistry Mol Molecular Biology
Translation:Animals
Stable potassium isotopes (41K/39K) track transcellular and paracellular potassium transport in biological systems. Front Physiol. 2022; 13:1016242. Higgins JA, Ramos DS, Gili S, Spetea C, Kanoski S, Ha D, McDonough AA, Youn JH. PMID: 36388124; PMCID: PMC9644202.

View in: PubMed Mentions: 2
Estimating in vivo potassium distribution and fluxes with stable potassium isotopes. Am J Physiol Cell Physiol. 2022 03 01; 322(3):C410-C420. Youn JH, Oh YT, Gili S, McDonough AA, Higgins J. PMID: 35080924; PMCID: PMC8917925.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Phy Physiology
Translation:Animals
Assessment of soluble epoxide hydrolase activity in vivo: A metabolomic approach. Prostaglandins Other Lipid Mediat. 2020 06; 148:106410. Stefanovski D, Shih PB, Hammock BD, Watanabe RM, Youn JH. PMID: 31931080; PMCID: PMC7237305.

View in: PubMed Mentions: 5 Fields:
End Endocrinology
Translation:Humans Animals
Interaction of Gut Microbiota and High-Sodium, Low-Potassium Diet in Altering Plasma Triglyceride Profiles Revealed by Lipidomics Analysis. Mol Nutr Food Res. 2019 12; 63(24):e1900752. Folz J, Oh YT, Blaženovic I, Richey J, Fiehn O, Youn JH. PMID: 31675161.

View in: PubMed Mentions: 4 Fields:
Nut Nutritional Sciences
Translation:Animals
Effects of Gut Bacteria Depletion and High-Na+ and Low-K+ Intake on Circulating Levels of Biogenic Amines. Mol Nutr Food Res. 2019 02; 63(4):e1801184. Blaženovic I, Oh YT, Li F, Ji J, Nguyen AK, Wancewicz B, Bender JM, Fiehn O, Youn JH. PMID: 30513547.

View in: PubMed Mentions: 4 Fields:
Nut Nutritional Sciences
Translation:Animals
Corrigendum to "Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity" [Free Radic. Biol. Med. 49 (2010):1522-1533]. Free Radic Biol Med. 2018 12; 129:614-617. Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS. PMID: 30076001.

View in: PubMed Mentions: Fields:
Bio Biochemistry Med Medicine (General)
Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 2017 11; 49:8-14. Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. PMID: 28863368; PMCID: PMC5858941.

View in: PubMed Mentions: 13 Fields:
Bio Biochemistry Nut Nutritional Sciences
Translation:Animals
Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 03; 32(2):100-111. McDonough AA, Youn JH. PMID: 28202621; PMCID: PMC5337831.

View in: PubMed Mentions: 53 Fields:
Phy Physiology
Translation:Humans Animals
Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 2016 12 01; 167:194-201. Oh YT, Oh HH, Nguyen AK, Choi CS, Youn JH. PMID: 27654062.

View in: PubMed Mentions: 6 Fields:
Beh Behavioral Sciences Phy Physiology Psy Psychophysiology
Translation:Animals
θ-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E154-60. Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH. PMID: 25991648; PMCID: PMC4504933.

View in: PubMed Mentions: 4 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75. Youn JH. PMID: 25344446.

View in: PubMed Mentions: 2 Fields:
End Endocrinology Met Metabolism
Translation:Humans
Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase Cγ1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97. Choi AY, Choi JH, Hwang KY, Jeong YJ, Choe W, Yoon KS, Ha J, Kim SS, Youn JH, Yeo EJ, Kang I. PMID: 24337903.

View in: PubMed Mentions: 29 Fields:
Cel Cell Biology
Translation:Humans Cells
Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. PMID: 24598799; PMCID: PMC4010681.

View in: PubMed Mentions: 82 Fields:
Nep Nephrology Phy Physiology
Translation:Animals Cells
Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology. 2014 Mar; 155(3):923-31. Oh YT, Kim J, Kang I, Youn JH. PMID: 24424035; PMCID: PMC3929730.

View in: PubMed Mentions: 13 Fields:
End Endocrinology
Translation:Animals
Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. McDonough AA, Youn JH. PMID: 23633048; PMCID: PMC3644996.

View in: PubMed Mentions: 12 Fields:
Nep Nephrology
Translation:Animals
Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56. Youn JH. PMID: 23953802; PMCID: PMC3748407.

View in: PubMed Mentions: 23 Fields:
Nep Nephrology
Translation:Humans Animals
Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74. Oh YT, Kim J, Youn JH. PMID: 23594607; PMCID: PMC3680793.

View in: PubMed Mentions: 10 Fields:
Phy Physiology
Translation:Animals Cells
A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92. Oh YT, Oh KS, Kang I, Youn JH. PMID: 22669895; PMCID: PMC3404348.

View in: PubMed Mentions: 9 Fields:
End Endocrinology
Translation:Animals
Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20. Stefanovski D, Youn JH, Rees M, Watanabe RM, Ader M, Ionut V, Jackson AU, Boehnke M, Collins FS, Bergman RN. PMID: 22456868; PMCID: PMC3329822.

View in: PubMed Mentions: 15 Fields:
End Endocrinology
Translation:Humans Animals Cells
Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55. Kang I, Kim SW, Youn JH. PMID: 21816780; PMCID: PMC3200242.

View in: PubMed Mentions: 12 Fields:
End Endocrinology Met Metabolism
Translation:Humans Animals Cells
Gut sensing of dietary K⁺ intake increases renal K⁺excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9. Oh KS, Oh YT, Kim SW, Kita T, Kang I, Youn JH. PMID: 21543632; PMCID: PMC3154709.

View in: PubMed Mentions: 25 Fields:
Phy Physiology
Translation:Animals
Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21. Oh YT, Oh KS, Choi YM, Jokiaho A, Donovan C, Choi S, Kang I, Youn JH. PMID: 21386057; PMCID: PMC3118587.

View in: PubMed Mentions: 18 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Carbonyl reductase 1 protects pancreatic β-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33. Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS. PMID: 20728534.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry Med Medicine (General)
Translation:Animals Cells
Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44. Choi S, Yoon H, Oh KS, Oh YT, Kim YI, Kang I, Youn JH. PMID: 20303128; PMCID: PMC2912158.

View in: PubMed Mentions: 17 Fields:
Met Metabolism
Translation:Animals Cells
eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53. Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU. PMID: 20124507.

View in: PubMed Mentions: 24 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7. Won JC, Park JY, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn JH, Lee KU. PMID: 19965780.

View in: PubMed Mentions: 34 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25. Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. PMID: 19414841; PMCID: PMC4944758.

View in: PubMed Mentions: 22 Fields:
Int Internal Medicine
Translation:Humans Animals
Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. Youn JH, McDonough AA. PMID: 18759636; PMCID: PMC4946439.

View in: PubMed Mentions: 50 Fields:
Phy Physiology
Translation:Humans Animals
AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. PMID: 18003746.

View in: PubMed Mentions: 12 Fields:
Cel Cell Biology Phy Physiology
Translation:Animals Cells
Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81. Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M, Kim SY, Kim MS, Kim SW, Park IS, Youn JH, Lee KU. PMID: 17827403.

View in: PubMed Mentions: 125 Fields:
End Endocrinology
Translation:Animals Cells
Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. Lee FN, Oh G, McDonough AA, Youn JH. PMID: 17522262.

View in: PubMed Mentions: 33 Fields:
Nep Nephrology Phy Physiology
Translation:Animals
Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7. Kim YI, Lee FN, Choi WS, Lee S, Youn JH. PMID: 16873695.

View in: PubMed Mentions: 61 Fields:
End Endocrinology
Translation:Animals Cells
Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. PMID: 16354756.

View in: PubMed Mentions: 18 Fields:
Cel Cell Biology Phy Physiology
Translation:Animals Cells
Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY. PMID: 16224049.

View in: PubMed Mentions: 40 Fields:
Vas Vascular Diseases
Translation:Humans Animals Cells
Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. McDonough AA, Youn JH. PMID: 16139689.

View in: PubMed Mentions: 13 Fields:
Nep Nephrology
Translation:Humans Animals Cells
alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):197-202. Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, Koh EH, Kim MS, Youn JH, Lee KU, Park JY. PMID: 15567171.

View in: PubMed Mentions: 20 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals
Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. PMID: 15213056.

View in: PubMed Mentions: 7 Fields:
Cel Cell Biology Phy Physiology
Translation:Animals
Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU. PMID: 15195087.

View in: PubMed Mentions: 136 Fields:
Med Medicine (General)Mol Molecular Biology
Translation:Animals Cells
Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74. Lee FN, Zhang L, Zheng D, Choi WS, Youn JH. PMID: 15026305.

View in: PubMed Mentions: 16 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU. PMID: 12941773.

View in: PubMed Mentions: 40 Fields:
End Endocrinology
Translation:Animals
Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. PMID: 12110527.

View in: PubMed Mentions: 51 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. McDonough AA, Thompson CB, Youn JH. PMID: 11997312.

View in: PubMed Mentions: 25 Fields:
Nep Nephrology Phy Physiology
Translation:Humans Animals Cells
Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. Choi CS, Lee FN, McDonough AA, Youn JH. PMID: 11916907.

View in: PubMed Mentions: 11 Fields:
End Endocrinology
Translation:Animals
Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84. Kim CH, Youn JH, Park JY, Hong SK, Park KS, Park SW, Suh KI, Lee KU. PMID: 10826998.

View in: PubMed Mentions: 22 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals
Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27. Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, Holloszy JO. PMID: 8460679.

View in: PubMed Mentions: 5 Fields:
Phy Physiology
Translation:Animals
Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 09; 1145(2):199-204. Ren JM, Youn JH, Gulve EA, Henriksen EJ, Holloszy JO. PMID: 8431452.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry Bio Biophysics
Translation:Animals
Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol (1985). 1992 Aug; 73(2):486-92. Slentz CA, Gulve EA, Rodnick KJ, Henriksen EJ, Youn JH, Holloszy JO. PMID: 1399970.

View in: PubMed Mentions: 11 Fields:
Phy Physiology
Translation:Animals
Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61. Youn JH, Gulve EA, Holloszy JO. PMID: 2003578.

View in: PubMed Mentions: 30 Fields:
Phy Physiology
Translation:Animals Cells
Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95. Gulve EA, Cartee GD, Youn JH, Holloszy JO. PMID: 1987782.

View in: PubMed Mentions: 1 Fields:
Phy Physiology
Translation:Animals
Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. Youn JH, Kaslow HR, Bergman RN. PMID: 3114246.

View in: PubMed Mentions: 10 Fields:
Bio Biochemistry
Translation:Animals Cells
Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 05; 261(34):15960-9. Youn JH, Youn MS, Bergman RN. PMID: 3023336.

View in: PubMed Mentions: 12 Fields:
Bio Biochemistry
Translation:Animals
Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48. Youn JH, Kim HC, Lee HK, Min BG. PMID: 6360264.

View in: PubMed Mentions: 1 Fields:
Bio Biology Sta Statistics as Topic
Translation:Humans