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Jang-Hyun Youn, PhD

Title(s)Associate Professor of Physiology & Neuroscience
Phone+1 323 442 3260
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Blaženovic I, Oh YT, Li F, Ji J, Nguyen AK, Wancewicz B, Bender JM, Fiehn O, Youn JH. Effects of Gut Bacteria Depletion and High-Na+ and Low-K+ Intake on Circulating Levels of Biogenic Amines. Mol Nutr Food Res. 2019 02; 63(4):e1801184. PMID: 30513547.
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    2. Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS. Corrigendum to "Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity" [Free Radic. Biol. Med. 49 (2010):1522-1533]. Free Radic Biol Med. 2018 Dec; 129:614-617. PMID: 30076001.
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    3. Yang J, Oh YT, Wan D, Watanabe RM, Hammock BD, Youn JH. Postprandial effect to decrease soluble epoxide hydrolase activity: roles of insulin and gut microbiota. J Nutr Biochem. 2017 11; 49:8-14. PMID: 28863368.
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    4. McDonough AA, Youn JH. Potassium Homeostasis: The Knowns, the Unknowns, and the Health Benefits. Physiology (Bethesda). 2017 03; 32(2):100-111. PMID: 28202621.
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    5. Oh YT, Oh HH, Nguyen AK, Choi CS, Youn JH. Circulating free fatty acids inhibit food intake in an oleate-specific manner in rats. Physiol Behav. 2016 12 01; 167:194-201. PMID: 27654062.
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    6. Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH. ?-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E154-60. PMID: 25991648.
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    7. Youn JH. Fat sensing and metabolic syndrome. Rev Endocr Metab Disord. 2014 Dec; 15(4):263-75. PMID: 25344446.
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    8. Choi AY, Choi JH, Hwang KY, Jeong YJ, Choe W, Yoon KS, Ha J, Kim SS, Youn JH, Yeo EJ, Kang I. Licochalcone A induces apoptosis through endoplasmic reticulum stress via a phospholipase C?1-, Ca(2+)-, and reactive oxygen species-dependent pathway in HepG2 human hepatocellular carcinoma cells. Apoptosis. 2014 Apr; 19(4):682-97. PMID: 24337903.
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    9. Rengarajan S, Lee DH, Oh YT, Delpire E, Youn JH, McDonough AA. Increasing plasma [K+] by intravenous potassium infusion reduces NCC phosphorylation and drives kaliuresis and natriuresis. Am J Physiol Renal Physiol. 2014 May 01; 306(9):F1059-68. PMID: 24598799.
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    10. Oh YT, Kim J, Kang I, Youn JH. Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology. 2014 Mar; 155(3):923-31. PMID: 24424035.
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    11. Youn JH. Gut sensing of potassium intake and its role in potassium homeostasis. Semin Nephrol. 2013 May; 33(3):248-56. PMID: 23953802.
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    12. McDonough AA, Youn JH. Need to quickly excrete K(+)? Turn off NCC. Kidney Int. 2013 May; 83(5):779-82. PMID: 23633048.
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    13. Oh YT, Kim J, Youn JH. Role of pituitary in K+ homeostasis: impaired renal responses to altered K+ intake in hypophysectomized rats. Am J Physiol Regul Integr Comp Physiol. 2013 Jun 15; 304(12):R1166-74. PMID: 23594607.
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    14. Oh YT, Oh KS, Kang I, Youn JH. A Fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology. 2012 Aug; 153(8):3587-92. PMID: 22669895.
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    15. Stefanovski D, Youn JH, Rees M, Watanabe RM, Ader M, Ionut V, Jackson AU, Boehnke M, Collins FS, Bergman RN. Estimating hepatic glucokinase activity using a simple model of lactate kinetics. Diabetes Care. 2012 May; 35(5):1015-20. PMID: 22456868.
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    16. Kang I, Kim SW, Youn JH. Effects of nicotinic acid on gene expression: potential mechanisms and implications for wanted and unwanted effects of the lipid-lowering drug. J Clin Endocrinol Metab. 2011 Oct; 96(10):3048-55. PMID: 21816780.
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    17. Oh KS, Oh YT, Kim SW, Kita T, Kang I, Youn JH. Gut sensing of dietary K? intake increases renal K?excretion. Am J Physiol Regul Integr Comp Physiol. 2011 Aug; 301(2):R421-9. PMID: 21543632.
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    18. Oh YT, Oh KS, Choi YM, Jokiaho A, Donovan C, Choi S, Kang I, Youn JH. Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. Am J Physiol Endocrinol Metab. 2011 Jun; 300(6):E1012-21. PMID: 21386057.
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    19. Rashid MA, Lee S, Tak E, Lee J, Choi TG, Lee JW, Kim JB, Youn JH, Kang I, Ha J, Kim SS. Carbonyl reductase 1 protects pancreatic ß-cells against oxidative stress-induced apoptosis in glucotoxicity and glucolipotoxicity. Free Radic Biol Med. 2010 Nov 30; 49(10):1522-33. PMID: 20728534.
      View in: PubMed
    20. Choi S, Yoon H, Oh KS, Oh YT, Kim YI, Kang I, Youn JH. Widespread effects of nicotinic acid on gene expression in insulin-sensitive tissues: implications for unwanted effects of nicotinic acid treatment. Metabolism. 2011 Jan; 60(1):134-44. PMID: 20303128.
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    21. Koh EH, Kim M, Ranjan KC, Kim HS, Park HS, Oh KS, Park IS, Lee WJ, Kim MS, Park JY, Youn JH, Lee KU. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E846-53. PMID: 20124507.
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    22. Won JC, Park JY, Kim YM, Koh EH, Seol S, Jeon BH, Han J, Kim JR, Park TS, Choi CS, Lee WJ, Kim MS, Lee IK, Youn JH, Lee KU. Peroxisome proliferator-activated receptor-gamma coactivator 1-alpha overexpression prevents endothelial apoptosis by increasing ATP/ADP translocase activity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):290-7. PMID: 19965780.
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    23. Greenlee M, Wingo CS, McDonough AA, Youn JH, Kone BC. Narrative review: evolving concepts in potassium homeostasis and hypokalemia. Ann Intern Med. 2009 May 05; 150(9):619-25. PMID: 19414841.
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    24. Youn JH, McDonough AA. Recent advances in understanding integrative control of potassium homeostasis. Annu Rev Physiol. 2009; 71:381-401. PMID: 18759636.
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    25. Zheng D, Perianayagam A, Lee DH, Brannan MD, Yang LE, Tellalian D, Chen P, Lemieux K, Marette A, Youn JH, McDonough AA. AMPK activation with AICAR provokes an acute fall in plasma [K+]. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C126-35. PMID: 18003746.
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    26. Koh EH, Park JY, Park HS, Jeon MJ, Ryu JW, Kim M, Kim SY, Kim MS, Kim SW, Park IS, Youn JH, Lee KU. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007 Dec; 56(12):2973-81. PMID: 17827403.
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    27. Lee FN, Oh G, McDonough AA, Youn JH. Evidence for gut factor in K+ homeostasis. Am J Physiol Renal Physiol. 2007 Aug; 293(2):F541-7. PMID: 17522262.
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    28. Kim YI, Lee FN, Choi WS, Lee S, Youn JH. Insulin regulation of skeletal muscle PDK4 mRNA expression is impaired in acute insulin-resistant states. Diabetes. 2006 Aug; 55(8):2311-7. PMID: 16873695.
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    29. Chen P, Guzman JP, Leong PK, Yang LE, Perianayagam A, Babilonia E, Ho JS, Youn JH, Wang WH, McDonough AA. Modest dietary K+ restriction provokes insulin resistance of cellular K+ uptake and phosphorylation of renal outer medulla K+ channel without fall in plasma K+ concentration. Am J Physiol Cell Physiol. 2006 May; 290(5):C1355-63. PMID: 16354756.
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    30. Lee WJ, Lee IK, Kim HS, Kim YM, Koh EH, Won JC, Han SM, Kim MS, Jo I, Oh GT, Park IS, Youn JH, Park SW, Lee KU, Park JY. Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2488-94. PMID: 16224049.
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    31. McDonough AA, Youn JH. Role of muscle in regulating extracellular [K+]. Semin Nephrol. 2005 Sep; 25(5):335-42. PMID: 16139689.
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    32. Song KH, Lee WJ, Koh JM, Kim HS, Youn JY, Park HS, Koh EH, Kim MS, Youn JH, Lee KU, Park JY. alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats. Biochem Biophys Res Commun. 2005 Jan 07; 326(1):197-202. PMID: 15567171.
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    33. Rhee MS, Perianayagam A, Chen P, Youn JH, McDonough AA. Dexamethasone treatment causes resistance to insulin-stimulated cellular potassium uptake in the rat. Am J Physiol Cell Physiol. 2004 Nov; 287(5):C1229-37. PMID: 15213056.
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    34. Kim MS, Park JY, Namkoong C, Jang PG, Ryu JW, Song HS, Yun JY, Namgoong IS, Ha J, Park IS, Lee IK, Viollet B, Youn JH, Lee HK, Lee KU. Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase. Nat Med. 2004 Jul; 10(7):727-33. PMID: 15195087.
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    35. Lee FN, Zhang L, Zheng D, Choi WS, Youn JH. Insulin suppresses PDK-4 expression in skeletal muscle independently of plasma FFA. Am J Physiol Endocrinol Metab. 2004 Jul; 287(1):E69-74. PMID: 15026305.
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    36. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU. Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation. Diabetes. 2003 Sep; 52(9):2331-7. PMID: 12941773.
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    37. Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. PMID: 12110527.
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    38. McDonough AA, Thompson CB, Youn JH. Skeletal muscle regulates extracellular potassium. Am J Physiol Renal Physiol. 2002 Jun; 282(6):F967-74. PMID: 11997312.
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    39. Choi CS, Lee FN, McDonough AA, Youn JH. Independent regulation of in vivo insulin action on glucose versus K(+) uptake by dietary fat and K(+) content. Diabetes. 2002 Apr; 51(4):915-20. PMID: 11916907.
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    40. Choi CS, Lee FN, Youn JH. Free fatty acids induce peripheral insulin resistance without increasing muscle hexosamine pathway product levels in rats. Diabetes. 2001 Feb; 50(2):418-24. PMID: 11272156.
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    41. Choi CS, Thompson CB, Leong PK, McDonough AA, Youn JH. Short-term K(+) deprivation provokes insulin resistance of cellular K(+) uptake revealed with the K(+) clamp. Am J Physiol Renal Physiol. 2001 Jan; 280(1):F95-F102. PMID: 11133519.
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    42. Kim CH, Youn JH, Park JY, Hong SK, Park KS, Park SW, Suh KI, Lee KU. Effects of high-fat diet and exercise training on intracellular glucose metabolism in rats. Am J Physiol Endocrinol Metab. 2000 Jun; 278(6):E977-84. PMID: 10826998.
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    43. Kim JK, Choi CS, Youn JH. Acute effect of growth hormone to induce peripheral insulin resistance is independent of FFA and insulin levels in rats. Am J Physiol. 1999 10; 277(4):E742-9. PMID: 10516135.
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    44. Thompson CB, Choi C, Youn JH, McDonough AA. Temporal responses of oxidative vs. glycolytic skeletal muscles to K+ deprivation: Na+ pumps and cell cations. Am J Physiol. 1999 06; 276(6):C1411-9. PMID: 10362605.
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    45. Wi JK, Kim JK, Youn JH. Reduced glucose clearance as the major determinant of postabsorptive hyperglycemia in diabetic rats. Am J Physiol. 1998 02; 274(2):E257-64. PMID: 9486156.
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    46. Kim JK, Youn JH. Prolonged suppression of glucose metabolism causes insulin resistance in rat skeletal muscle. Am J Physiol. 1997 Feb; 272(2 Pt 1):E288-96. PMID: 9124337.
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    47. Ozel B, Youngren JF, Kim JK, Goldfine ID, Sung CK, Youn JH. The development of insulin resistance with high fat feeding in rats does not involve either decreased insulin receptor tyrosine kinase activity or membrane glycoprotein PC-1. Biochem Mol Med. 1996 Dec; 59(2):174-81. PMID: 8986641.
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    48. Steil GM, Richey J, Kim JK, Wi JK, Rebrin K, Bergman RN, Youn JH. Extracellular glucose distribution is not altered by insulin: analysis of plasma and interstitial L-glucose kinetics. Am J Physiol. 1996 Nov; 271(5 Pt 1):E855-64. PMID: 8944672.
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    49. Kim JK, Wi JK, Youn JH. Metabolic impairment precedes insulin resistance in skeletal muscle during high-fat feeding in rats. Diabetes. 1996 May; 45(5):651-8. PMID: 8621018.
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    50. Wi JK, Kim JK, Youn JH. Mechanisms of postabsorptive hyperglycemia in streptozotocin diabetic rats. Am J Physiol. 1996 May; 270(5 Pt 1):E752-8. PMID: 8967462.
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    51. Kim JK, Wi JK, Youn JH. Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 1996 Apr; 45(4):446-53. PMID: 8603766.
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    52. Youn JH, Kim JK, Steil GM. Assessment of extracellular glucose distribution and glucose transport activity in conscious rats. Am J Physiol. 1995 Apr; 268(4 Pt 1):E712-21. PMID: 7733271.
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    53. Youn JH, Gulve EA, Henriksen EJ, Holloszy JO. Interactions between effects of W-7, insulin, and hypoxia on glucose transport in skeletal muscle. Am J Physiol. 1994 Oct; 267(4 Pt 2):R888-94. PMID: 7943429.
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    54. Youn JH, Kim JK, Buchanan TA. Time courses of changes in hepatic and skeletal muscle insulin action and GLUT4 protein in skeletal muscle after STZ injection. Diabetes. 1994 Apr; 43(4):564-71. PMID: 8138062.
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    55. Youn JH, Buchanan TA. Fasting does not impair insulin-stimulated glucose uptake but alters intracellular glucose metabolism in conscious rats. Diabetes. 1993 May; 42(5):757-63. PMID: 8482433.
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    56. Gulve EA, Henriksen EJ, Rodnick KJ, Youn JH, Holloszy JO. Glucose transporters and glucose transport in skeletal muscles of 1- to 25-mo-old rats. Am J Physiol. 1993 Mar; 264(3 Pt 1):E319-27. PMID: 8460679.
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    57. Ren JM, Youn JH, Gulve EA, Henriksen EJ, Holloszy JO. Effects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle. Biochim Biophys Acta. 1993 Feb 09; 1145(2):199-204. PMID: 8431452.
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    58. Slentz CA, Gulve EA, Rodnick KJ, Henriksen EJ, Youn JH, Holloszy JO. Glucose transporters and maximal transport are increased in endurance-trained rat soleus. J Appl Physiol (1985). 1992 Aug; 73(2):486-92. PMID: 1399970.
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    59. Buchanan TA, Youn JH, Campese VM, Sipos GF. Enhanced glucose tolerance in spontaneously hypertensive rats. Pancreatic beta-cell hyperfunction with normal insulin sensitivity. Diabetes. 1992 Jul; 41(7):872-8. PMID: 1612202.
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    60. Youn JH, Bergman RN. Conversion of oral glucose to lactate in dogs. Primary site and relative contribution to blood lactate. Diabetes. 1991 Jun; 40(6):738-47. PMID: 2040389.
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    61. Youn JH, Gulve EA, Holloszy JO. Calcium stimulates glucose transport in skeletal muscle by a pathway independent of contraction. Am J Physiol. 1991 Mar; 260(3 Pt 1):C555-61. PMID: 2003578.
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    62. Gulve EA, Cartee GD, Youn JH, Holloszy JO. Prolonged incubation of skeletal muscle increases system A amino acid transport. Am J Physiol. 1991 Jan; 260(1 Pt 1):C88-95. PMID: 1987782.
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    63. Youn JH, Bergman RN. Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control? Am J Physiol. 1990 Jun; 258(6 Pt 1):E899-906. PMID: 2193531.
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    64. Bergman RN, Hope ID, Yang YJ, Watanabe RM, Meador MA, Youn JH, Ader M. Assessment of insulin sensitivity in vivo: a critical review. Diabetes Metab Rev. 1989 Aug; 5(5):411-29. PMID: 2667927.
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    65. Youn JH, Ader M, Bergman RN. Glucose phosphorylation is not rate limiting for accumulation of glycogen from glucose in perfused livers from fasted rats. J Biol Chem. 1989 Jan 05; 264(1):168-72. PMID: 2642472.
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    66. Cane P, Haun CK, Evered J, Youn JH, Bergman RN. Response to deep hypoglycemia does not involve glucoreceptors in carotid perfused tissue. Am J Physiol. 1988 Nov; 255(5 Pt 1):E680-7. PMID: 2847539.
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    67. Antwi D, Youn JH, Shargill NS, Lesikar DD, Kaslow HR. Regulation of glycogen synthase in muscle and adipose tissue during fasting and refeeding. Am J Physiol. 1988 Jun; 254(6 Pt 1):E720-5. PMID: 3132046.
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    68. Yang YJ, Youn JH, Bergman RN. Modified protocols improve insulin sensitivity estimation using the minimal model. Am J Physiol. 1987 Dec; 253(6 Pt 1):E595-602. PMID: 2892414.
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    69. Youn JH, Bergman RN. Patterns of glycogen turnover in liver characterized by computer modeling. Am J Physiol. 1987 Oct; 253(4 Pt 1):E360-9. PMID: 3661699.
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    70. Youn JH, Kaslow HR, Bergman RN. Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. PMID: 3114246.
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    71. Youn JH, Youn MS, Bergman RN. Synergism of glucose and fructose in net glycogen synthesis in perfused rat livers. J Biol Chem. 1986 Dec 05; 261(34):15960-9. PMID: 3023336.
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    72. Youn JH, Kim HC, Lee HK, Min BG. Computed insulin profiles for normalization of glycemia in diabetic patients. Bull Math Biol. 1983; 45(5):739-48. PMID: 6360264.
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