Michael E. Selsted, MD, PhD
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Title(s) | Professor of Pathology |
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School | Keck School of Medicine of Usc |
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Address | HMR 2011 Zonal Ave Health Sciences Campus Los Angeles CA 90089-9092
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Phone | +1 323 442 1180 |
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vCard | Download vCard |
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Overview
Dr. Selsted is a board certified pathologist, physician scientist, and administrator. His academic career includes appointments as Professor (1989-2009) and Chair of Pathology at UC Irvine School of Medicine (2000 - 2009) and Professor and Chair of Pathology in the Keck School of Medicine (2009 - 2024). Dr. Selsted leads a multidisciplinary research program focused on mammalian host defense, innate immunity, and inflammation. This focus led to the discovery and characterization of α-, β-, and θ-defensins, microbicidal and immunomodulatory peptides expressed in myeloid and epithelial cells of vertebrates. These investigations, continuously funded by NIH since 1986, have resulted in more than 50 US and foreign patents, as well as clinical translation of a θ-defensin for treatment of rheumatoid arthritis. Ongoing studies seek to elucidate the immunoregulatory mechanisms of these peptides, design and application of novel analogs, and application of θ-defensin-inspired macrocyclic peptides in models of autoimmune diseases, cancer, and infections caused by MDR bacterial and fungal pathogens.
Research