Harvey R Kaslow, PhD

Title(s)Associate Professor of Physiology & Neuroscience
SchoolKeck School of Medicine of Usc
AddressMCH 250, 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 1244
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    More complete information at USC Health Sciences Profiles:
    https://profiles.sc-ctsi.org/harvey.kaslow
    This URL can be obtained by searching Google for "Harvey Kaslow CTSI."

    Main research interest: Cancer Immunotherapy and Regulation of Immune Responses.
    Cytotoxic antibodies and T lymphocytes can be generated that recognize cancer cells, but immunosuppressive factors in solid tumors frequently cause these effectors to fail to control or eliminate the cancer. Compositions are available that overcome these immunosuppressive factors but they produce toxic side-effects which can be life-threatening. There is thus a need for efficacious compositions and methods with reduced toxicity. In collaboration with the laboratory of Alan Epstein (Keck School of Medicine) candidate compositions and methods have been generated and more are under development. Patents covering some compositions and methods have issued and additional patent applications are ongoing and planned. See:
    https://onedrive.live.com/view.aspx?resid=8981C17A0B407A86!39098&ithint=file%2cpptx&authkey=!ACYUwJ4HG0p1NRw

    Education Efforts:
    Dr. Kaslow’s graduate (UCSD) work involved endocrinology and metabolism and his post-doctoral (UCSF) research focused on cell signaling mechanisms. His teaching efforts continue in those areas in graduate, medical, and pharmacy courses. Dr. Kaslow serves as:
    Director, MS program in Medical Physiology
    Co-chair of the Endocrinology section of the medical student curriculum.
    Dr. Kaslow actively participates in the continuing refinement and revision of the medical and graduate student curricula and is developing software for the analysis and management of the curriculum.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. A Humanized Lym-1 CAR with Novel DAP10/DAP12 Signaling Domains Demonstrates Reduced Tonic Signaling and Increased Antitumor Activity in B-Cell Lymphoma Models. Clin Cancer Res. 2020 07 15; 26(14):3694-3706. Zheng L, Ren L, Kouhi A, Khawli LA, Hu P, Kaslow HR, Epstein AL. PMID: 32273277.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    2. Lym-1 Chimeric Antigen Receptor T Cells Exhibit Potent Anti-Tumor Effects against B-Cell Lymphoma. Int J Mol Sci. 2017 Dec 20; 18(12). Zheng L, Hu P, Wolfe B, Gonsalves C, Ren L, Khawli LA, Kaslow HR, Epstein AL. PMID: 29261129; PMCID: PMC5751371.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. P2X7 receptor-dependent and -independent T cell death is induced by nicotinamide adenine dinucleotide. J Immunol. 2005 Feb 15; 174(4):1971-9. Kawamura H, Aswad F, Minagawa M, Malone K, Kaslow H, Koch-Nolte F, Schott WH, Leiter EH, Dennert G. PMID: 15699125.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    4. Expression of IL-10 and TNF-inhibitor genes in lacrimal gland epithelial cells suppresses their ability to activate lymphocytes. Cornea. 2002 Mar; 21(2):210-4. Zhu Z, Stevenson D, Ritter T, Schechter JE, Mircheff AK, Kaslow HR, Trousdale MD. PMID: 11862098.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    5. Effect of anti-inflammatory cytokines on the activation of lymphocytes by lacrimal gland acinar cells in an autologous mixed cell reaction. Adv Exp Med Biol. 2002; 506(Pt B):789-94. Trousdale MD, Stevenson D, Zhu Z, Kaslow HR, Schechter JE, Warren DW, Azzarolo AM, Ritter T, Mircheff AK. PMID: 12613993.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    6. Lacrimal gland epithelial cells stimulate proliferation in autologous lymphocyte preparations. Exp Eye Res. 2000 Jul; 71(1):11-22. Guo Z, Azzarolo AM, Schechter JE, Warren DW, Wood RL, Mircheff AK, Kaslow HR. PMID: 10880272.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    7. Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits. Exp Eye Res. 2000 Jul; 71(1):23-31. Guo Z, Song D, Azzarolo AM, Schechter JE, Warren DW, Wood RL, Mircheff AK, Kaslow HR. PMID: 10880273.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    8. A method to study induction of autoimmunity in vitro: co-culture of lacrimal cells and autologous immune system cells. Adv Exp Med Biol. 1998; 438:583-9. Kaslow HR, Guo Z, Warren DW, Wood RL, Mircheff AK. PMID: 9634940.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez SF, Okamoto CT, Bachmann M. PMID: 10076804.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    10. Authors and Editors of the world unite. FASEB J. 1995 Feb; 9(2):291. Kaslow HR. PMID: 7781934.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Molecular engineering of cholera toxin. Adv Exp Med Biol. 1995; 371B:1513-8. Burnette WN, Kaslow HR, Moss J. PMID: 7502847.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Regulation of cytotoxic T cells by ecto-nicotinamide adenine dinucleotide (NAD) correlates with cell surface GPI-anchored/arginine ADP-ribosyltransferase. J Immunol. 1994 Nov 01; 153(9):4048-58. Wang J, Nemoto E, Kots AY, Kaslow HR, Dennert G. PMID: 7930612.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    13. Construction and characterization of recombinant Vibrio cholerae strains producing inactive cholera toxin analogs. Infect Immun. 1994 Aug; 62(8):3051-7. Häse CC, Thai LS, Boesman-Finkelstein M, Mar VL, Burnette WN, Kaslow HR, Stevens LA, Moss J, Finkelstein RA. PMID: 8039872; PMCID: PMC302926.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    14. Recombinant microbial ADP-ribosylating toxins of Bordetella pertussis, Vibrio cholerae, and enterotoxigenic Escherichia coli: structure, function, and toxoid vaccine development. Bioprocess Technol. 1994; 19:185-203. Burnette WN, Cieplak W, Kaslow HR, Rappuoli R, Tuomanen EI. PMID: 7764758.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    15. CTX-B inhibits CTL cytotoxicity and cytoskeletal movements. Immunopharmacology. 1993 Sep-Oct; 26(2):93-104. Sugawara S, Kaslow HR, Dennert G. PMID: 8282542.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    16. Pertussis toxin and target eukaryotic cells: binding, entry, and activation. FASEB J. 1992 Jun; 6(9):2684-90. Kaslow HR, Burns DL. PMID: 1612292.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    17. Detection of antibodies inhibiting the ADP-ribosyltransferase activity of pertussis toxin in human serum. J Clin Microbiol. 1992 Jun; 30(6):1380-7. Kaslow HR, Platler BW, Blumberg DA, Cherry JD. PMID: 1624552; PMCID: PMC265296.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    18. Site-specific mutagenesis of the catalytic subunit of cholera toxin: substituting lysine for arginine 7 causes loss of activity. Infect Immun. 1991 Nov; 59(11):4266-70. Burnette WN, Mar VL, Platler BW, Schlotterbeck JD, McGinley MD, Stoney KS, Rohde MF, Kaslow HR. PMID: 1937784; PMCID: PMC259028.
      View in: PubMed   Mentions: 14     Fields:    
    19. Evaluation of antibodies elicited by immunization with pertussis toxin. Dev Biol Stand. 1991; 73:143-50. Kaslow HR, Schlotterbeck JD, Gotto J. PMID: 1778308.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    20. Monoclonal antibodies against the enzymatic subunit of both pertussis and cholera toxins. Dev Biol Stand. 1991; 73:133-41. Kenimer JG, Probst PG, Karpas AB, Burns DL, Kaslow HR. PMID: 1778307.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    21. The molecular engineering of pertussis toxoid. Dev Biol Stand. 1991; 73:75-8. Burnette WN, Mar VL, Bartley TD, Kaslow HR, Cieplak W, Keith JM, Sato H, Burns DL, Arciniega JL, Shahin RD, et al. PMID: 1778336.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Monoclonal antibodies that inhibit ADP-ribosyltransferase but not NAD-glycohydrolase activity of pertussis toxin. Infect Immun. 1990 Mar; 58(3):746-52. Kaslow HR, Schlotterbeck JD, Kenimer JG. PMID: 2155182; PMCID: PMC258528.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    23. Radiometric assays for glycerol, glucose, and glycogen. Anal Biochem. 1989 Jul; 180(1):11-6. Bradley DC, Kaslow HR. PMID: 2817333.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    24. Alkylation of cysteine 41, but not cysteine 200, decreases the ADP-ribosyltransferase activity of the S1 subunit of pertussis toxin. J Biol Chem. 1989 Apr 15; 264(11):6386-90. Kaslow HR, Schlotterbeck JD, Mar VL, Burnette WN. PMID: 2703495.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    25. Developments toward a recombinant pertussis vaccine. Adv Exp Med Biol. 1989; 251:1-7. Burnette WN, Whiteley DW, Mar VL, Burns DL, Kaslow HR, Cieplak W, Keith JM, Bartley TD. PMID: 2692423.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    26. Regulation of glycogen synthase in muscle and adipose tissue during fasting and refeeding. Am J Physiol. 1988 Jun; 254(6 Pt 1):E720-5. Antwi D, Youn JH, Shargill NS, Lesikar DD, Kaslow HR. PMID: 3132046.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    27. Fructose effect to suppress hepatic glycogen degradation. J Biol Chem. 1987 Aug 25; 262(24):11470-7. Youn JH, Kaslow HR, Bergman RN. PMID: 3114246.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Sulfhydryl-alkylating reagents inactivate the NAD glycohydrolase activity of pertussis toxin. Biochemistry. 1987 Jul 14; 26(14):4397-402. Kaslow HR, Lesikar DD. PMID: 2822091.
      View in: PubMed   Mentions: 5     Fields:    
    29. Structure-activity analysis of the activation of pertussis toxin. Biochemistry. 1987 Jan 13; 26(1):123-7. Kaslow HR, Lim LK, Moss J, Lesikar DD. PMID: 3030399.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    30. Stimulation of the thiol-dependent ADP-ribosyltransferase and NAD glycohydrolase activities of Bordetella pertussis toxin by adenine nucleotides, phospholipids, and detergents. Biochemistry. 1986 May 06; 25(9):2720-5. Moss J, Stanley SJ, Watkins PA, Burns DL, Manclark CR, Kaslow HR, Hewlett EL. PMID: 2872921.
      View in: PubMed   Mentions: 21     Fields:    Translation:Cells
    31. L-type glycogen synthase. Tissue distribution and electrophoretic mobility. J Biol Chem. 1985 Aug 25; 260(18):9953-6. Kaslow HR, Lesikar DD, Antwi D, Tan AW. PMID: 3926776.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    32. Adenine nucleotides directly stimulate pertussis toxin. J Biol Chem. 1985 Mar 10; 260(5):2585-8. Lim LK, Sekura RD, Kaslow HR. PMID: 2982826.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    33. Fasting and diabetes alter adipose tissue glycogen synthase. Am J Physiol. 1984 Nov; 247(5 Pt 1):E581-4. Kaslow HR, Eichner RD. PMID: 6437248.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    34. Isozymes of glycogen synthase. FEBS Lett. 1984 Jul 09; 172(2):294-8. Kaslow HR, Lesikar DD. PMID: 6430719.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    35. Genetic analysis of cyclic nucleotide phosphodiesterases in S49 mouse lymphoma cells. Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984; 16:185-94. Bourne HR, Brothers VM, Kaslow HR, Groppi V, Walker N, Steinberg F. PMID: 6326523.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    36. A direct radioassay for pyruvate kinase activity. Anal Biochem. 1983 Oct 15; 134(2):495-8. Kaslow HR, Garrison CR. PMID: 6418026.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    37. Identification by direct photoaffinity labeling of an altered phosphodiesterase in a mutant S49 lymphoma cell. J Biol Chem. 1983 Aug 25; 258(16):9717-23. Groppi VE, Steinberg F, Kaslow HR, Walker N, Bourne HR. PMID: 6309783.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    38. Cholera toxin can catalyze ADP-ribosylation of cytoskeletal proteins. J Cell Biol. 1981 Nov; 91(2 Pt 1):410-3. Kaslow HR, Groppi VE, Abood ME, Bourne HR. PMID: 7309789; PMCID: PMC2111969.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    39. Fibroblast defect in pseudohypoparathyroidism, type I: reduced activity of receptor-cyclase coupling protein. J Clin Endocrinol Metab. 1981 Sep; 53(3):636-40. Bourne HR, Kaslow HR, Brickman AS, Farfel Z. PMID: 6267099.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    40. Hormone-sensitive adenylate cyclase. Mutant phenotype with normally regulated beta-adrenergic receptors uncoupled with catalytic adenylate cyclase. Mol Pharmacol. 1981 Sep; 20(2):435-41. Bourne HR, Kaslow D, Kaslow HR, Salomon MR, Licko V. PMID: 6272096.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    41. An Mr = 52,000 peptide can mediate effects on cholera toxin on adenylate cyclase in intact cells. Mol Pharmacol. 1981 May; 19(3):406-10. Kaslow HR, Cox D, Groppi VE, Bourne HR. PMID: 6790933.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Human mutation affecting hormone-sensitive adenylate cyclase. Prog Clin Biol Res. 1981; 63:433-7. Bourne HR, Farfel Z, Brickman AS, Kaslow HR, Brothers VM. PMID: 6273928.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    43. Apparent phosphorylation of glycogen synthase in mammalian cells lacking cyclic AMP-dependent protein kinase. FEBS Lett. 1980 Aug 11; 117(1):219-23. Kaslow HR. PMID: 6773808.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    44. Defect of receptor-cyclase coupling protein in psudohypoparathyroidism. N Engl J Med. 1980 Jul 31; 303(5):237-42. Farfel Z, Brickman AS, Kaslow HR, Brothers VM, Bourne HR. PMID: 6247654.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    45. A regulatory component of adenylate cyclase from human erythrocyte membranes. J Biol Chem. 1980 Apr 25; 255(8):3736-41. Kaslow HR, Johnson GL, Brothers VM, Bourne HR. PMID: 7364766.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    46. Genetic analysis of hormone-sensitive adenylate cyclase. Adv Cyclic Nucleotide Res. 1980; 13:1-37. Johnson GL, Kaslow HR, Farfel Z, Bourne HR. PMID: 6251703.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    47. A regulatory component of adenylate cyclase is located on the inner surface of human erythrocyte membranes. Biochem Biophys Res Commun. 1979 Oct 29; 90(4):1237-41. Farfel Z, Kaslow HR, Bourne HR. PMID: 518596.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    48. Interconversion between multiple glucose 6-phosphate-dependent forms of glycogen synthase in intact adipose tissue. J Biol Chem. 1979 Jun 10; 254(11):4674-7. Kaslow HR, Eichner RD, Mayer SE. PMID: 108279.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    49. Adaptations of glycogen metabolism in rat epididymal adipose tissue during fasting and refeeding. J Biol Chem. 1979 Jun 10; 254(11):4678-83. Kaslow HR, Mayer SE. PMID: 108280.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    50. Adenylate cyclase assembled in vitro: cholera toxin substrates determine different patterns of regulation by isoproterenol and guanosine 5'-triphosphate. Mol Pharmacol. 1979 May; 15(3):472-83. Kaslow HR, Farfel Z, Johnson GL, Bourne HR. PMID: 226858.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    51. Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. J Biol Chem. 1978 Oct 25; 253(20):7120-3. Johnson GL, Kaslow HR, Bourne HR. PMID: 212417.
      View in: PubMed   Mentions: 46     Fields:    Translation:Cells
    52. Reconstitution of cholera toxin-activated adenylate cyclase. Proc Natl Acad Sci U S A. 1978 Jul; 75(7):3113-7. Johnson GL, Kaslow HR, Bourne HR. PMID: 277913; PMCID: PMC392724.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    53. Purification of the cAMP receptor protein by affinity chromatography. Biochem Biophys Res Commun. 1974 Jul 24; 59(2):813-21. Ramseyer J, Kaslow HR, Gill GN. PMID: 4369094.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
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