Sarah Hamm-Alvarez, PhD

Title(s)Professor of Ophthalmology and Pharmacology and Pharmaceutical Sciences
SchoolKeck School of Medicine of Usc
AddressMCA 346A 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
Phone+1 323 442 1445
vCardDownload vCard
    Other Positions
    Title(s)Associate Dean for Basic and Translational Research


    Collapse Biography 
    Collapse Education and Training
    Carleton College, Northfield, MNBA1986Chemistry
    Duke University, Durham, NCPh. D.1990Biochemistry
    Duke University, Durham, NCpostdoctoral1993Cell Biology
    Collapse Awards and Honors
    Duke University1991  - 1993Muscular Dystrophy Association Postdoctoral Fellow
    American Heart Association1994  - 1996Initial Investigatorship
    Linneaus University, Kalmar Sweden2003Doctor of Philosophy, honoris causa
    USC School of Pharmacy2003John A. Biles Professor of Pharmaceutical Sciences
    USC School of Pharmacy2004  - 2015Gavin S. Herbert Professor of Pharmaceutical Sciences
    2010  - 2011Higher Education Resource Services (HERS) Representative
    American Association of Pharmaceutical Scientists2014Fellow

    Collapse Overview 
    Collapse Overview
    Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

    An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

    Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.

    Collapse Research 
    Collapse Research Activities and Funding
    Development of a novel tear-based biomarker assay for diagnosis of Parkinson's disease using RT-QuIC
    NIH R21AG066070Aug 1, 2020 - Apr 30, 2022
    Role: Principal Investigator
    Protein-polymer nanomedicine for Sjogren's Syndrome
    NIH R01EY026635Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Protein-polymer nanomedicines for Sjogren's syndrome
    National Institutes of Health/National Eye Institute RO1EY026635-0A1Mar 1, 2017 - Feb 28, 2021
    Role: One of two multi-PI investigators with JA MacKay
    Identification of tear biomarkers for Parkinson's disease patients
    Michael J Fox Foundation Jan 1, 2017 - Dec 31, 2018
    Role: Principal Investigator
    Trafficking of plgR in Lacrimal Gland
    NIH R01EY016985Aug 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Ad5 Fiber Entry and Trafficking in Lacrimal Acini
    NIH R01EY017293Apr 3, 2006 - Mar 31, 2012
    Role: Principal Investigator
    Adenovirus Modulation of Lacrimal Gland Function
    NIH R03EY013949Apr 1, 2003 - Mar 31, 2006
    Role: Principal Investigator
    Microtubule-based Transport in Lacrimal Gland Function
    NIH R01EY011386Jul 1, 1996 - Jun 30, 2026
    Role: Principal Investigator
    CELLULAR MECHANISMS OF TAXOL TOXICITY
    NIH R29CA063387Apr 1, 1994 - May 15, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Aging Lacrimal Gland of Female C57BL/6J Mice Exhibits Multinucleate Macrophage Infiltration Associated With Lipid Dysregulation. Invest Ophthalmol Vis Sci. 2024 Jun 03; 65(6):1. Choi M, Toscano C, Edman MC, de Paiva CS, Hamm-Alvarez SF. PMID: 38829671; PMCID: PMC11156205.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Effects of age on lacrimal gland bioactive lipids. Ocul Surf. 2024 Jul; 33:64-73. Ebright B, Yu Z, Dave P, Dikeman D, Hamm-Alvarez S, de Paiva CS, Louie S. PMID: 38705236.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. The miRNA Landscape of Lacrimal Glands in a Murine Model of Autoimmune Dacryoadenitis. Invest Ophthalmol Vis Sci. 2023 04 03; 64(4):1. Singh Kakan S, Li X, Edman MC, Okamoto CT, Hjelm BE, Hamm-Alvarez SF. PMID: 37010857; PMCID: PMC10080918.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    4. Tear miRNAs Identified in a Murine Model of Sjögren's Syndrome as Potential Diagnostic Biomarkers and Indicators of Disease Mechanism. Front Immunol. 2022; 13:833254. Kakan SS, Edman MC, Yao A, Okamoto CT, Nguyen A, Hjelm BE, Hamm-Alvarez SF. PMID: 35309364; PMCID: PMC8931289.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    5. Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren's syndrome. Biomaterials. 2022 04; 283:121441. Guo H, Ju Y, Choi M, Edman MC, Louie SG, Hamm-Alvarez SF, MacKay JA. PMID: 35306230; PMCID: PMC8982551.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    6. Intracellular Dynamin Elastin-like Polypeptides Assemble into Rodlike, Spherical, and Reticular Dynasomes. Biomacromolecules. 2022 01 10; 23(1):265-275. Avila H, Truong A, Tyrpak D, Park SJ, Lei S, Li Y, Okamoto C, Hamm-Alvarez S, MacKay JA. PMID: 34914359; PMCID: PMC9159747.
      View in: PubMed   Mentions: 1     Fields:    
    7. Cathepsin S is a novel target for age-related dry eye. Exp Eye Res. 2022 01; 214:108895. Yu Z, Li J, Govindarajan G, Hamm-Alvarez SF, Alam J, Li DQ, de Paiva CS. PMID: 34910926; PMCID: PMC8908478.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    8. Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye. Exp Biol Med (Maywood). 2022 03; 247(6):519-526. Lu G, Gollapudi S, Li R, Pfeiffer ML, Mehta P, Jiang L, Hamm-Alvarez S, Humayun M, Zhou Q, Zhang-Nunes SX. PMID: 34648358; PMCID: PMC8943330.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    9. Phenylephrine increases tear cathepsin S secretion in healthy murine lacrimal gland acinar cells through an alternative secretory pathway. Exp Eye Res. 2021 10; 211:108760. Fu R, Janga S, Edman MC, Hamm-Alvarez SF. PMID: 34487726; PMCID: PMC8511144.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Rab27a Contributes to Cathepsin S Secretion in Lacrimal Gland Acinar Cells. Int J Mol Sci. 2021 Feb 05; 22(4). Fu R, Edman MC, Hamm-Alvarez SF. PMID: 33562815; PMCID: PMC7914720.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    11. Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome. Biomacromolecules. 2021 03 08; 22(3):1102-1114. Ju Y, Edman MC, Guo H, Janga SR, Peddi S, Louie SG, Junge JA, MacKay JA, Hamm-Alvarez SF. PMID: 33356170; PMCID: PMC8015671.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium. Int J Mol Sci. 2020 Aug 26; 21(17). Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA. PMID: 32859014; PMCID: PMC7504496.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Application of advances in endocytosis and membrane trafficking to drug delivery. Adv Drug Deliv Rev. 2020; 157:118-141. Ju Y, Guo H, Edman M, Hamm-Alvarez SF. PMID: 32758615; PMCID: PMC7853512.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    14. Small RNA Deep Sequencing Identifies a Unique miRNA Signature Released in Serum Exosomes in a Mouse Model of Sjögren's Syndrome. Front Immunol. 2020; 11:1475. Kakan SS, Janga SR, Cooperman B, Craig DW, Edman MC, Okamoto CT, Hamm-Alvarez SF. PMID: 32849505; PMCID: PMC7396589.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    15. Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption. Transl Vis Sci Technol. 2020 07; 9(8):23. Ameri H, Murat C, Arbabi A, Jiang W, Janga SR, Qin PZ, Hamm-Alvarez SF. PMID: 32855870; PMCID: PMC7422915.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    16. A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye. Int J Mol Sci. 2020 Apr 15; 21(8). Hsueh PY, Ju Y, Vega A, Edman MC, MacKay JA, Hamm-Alvarez SF. PMID: 32326657; PMCID: PMC7216292.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease. Eye Contact Lens. 2020 Mar; 46 Suppl 2:S70-S83. Fu R, Klinngam W, Heur M, Edman MC, Hamm-Alvarez SF. PMID: 31369467; PMCID: PMC6992486.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Tears - more to them than meets the eye: why tears are a good source of biomarkers in Parkinson's disease. Biomark Med. 2020 02; 14(2):151-163. Edman MC, Janga SR, Kakan SS, Okamoto CT, Freire D, Feigenbaum D, Lew M, Hamm-Alvarez SF. PMID: 32064896.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    19. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model. Sci Rep. 2020 01 29; 10(1):1455. Fu R, Guo H, Janga S, Choi M, Klinngam W, Edman MC, Hamm-Alvarez SF. PMID: 31996771; PMCID: PMC6989636.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Caveolin elastin-like polypeptide fusions mediate temperature-dependent assembly of caveolar microdomains. ACS Biomater Sci Eng. 2020 01 13; 6(1):198-204. Tyrpak DR, Wang Y, Avila H, Guo H, Fu R, Truong AT, Park M, Okamoto CT, Hamm-Alvarez SF, MacKay JA. PMID: 32542186; PMCID: PMC7295141.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    21. Levels of oligomeric α-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls. Biomark Med. 2019 12; 13(17):1447-1457. Hamm-Alvarez SF, Janga SR, Edman MC, Feigenbaum D, Freire D, Mack WJ, Okamoto CT, Lew MF. PMID: 31552762.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    22. Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide. Bioconjug Chem. 2019 09 18; 30(9):2358-2372. Ju Y, Guo H, Yarber F, Edman MC, Peddi S, Janga SR, MacKay JA, Hamm-Alvarez SF. PMID: 31408605; PMCID: PMC6980866.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. Oligomeric α-synuclein is increased in basal tears of Parkinson's patients. Biomark Med. 2019 08; 13(11):941-952. Hamm-Alvarez SF, Okamoto CT, Janga SR, Feigenbaum D, Edman MC, Freire D, Shah M, Ghanshani R, Mack WJ, Lew MF. PMID: 31262201.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCTClinical Trials
    24. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome. Sci Rep. 2019 07 02; 9(1):9559. Klinngam W, Janga SR, Lee C, Ju Y, Yarber F, Shah M, Guo H, Wang D, MacKay JA, Edman MC, Hamm-Alvarez SF. PMID: 31267034; PMCID: PMC6606642.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    25. PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 Jul 01; 200(1):6-8. Janga SR, Hamm-Alvarez SF. PMID: 30785780; PMCID: PMC6603066.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. Mol Pharm. 2019 07 01; 16(7):3024-3039. Lee C, Guo H, Klinngam W, Janga SR, Yarber F, Peddi S, Edman MC, Tiwari N, Liu S, Louie SG, Hamm-Alvarez SF, MacKay JA. PMID: 31095909; PMCID: PMC6957305.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    27. Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells. Int J Mol Sci. 2018 Nov 09; 19(11). Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF. PMID: 30423938; PMCID: PMC6274678.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    28. A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. J Control Release. 2018 12 28; 292:183-195. Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA. PMID: 30359668; PMCID: PMC6294338.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    29. Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome. Biomarkers. 2019 Feb; 24(1):91-102. Janga SR, Shah M, Ju Y, Meng Z, Edman MC, Hamm-Alvarez SF. PMID: 30126300; PMCID: PMC6414277.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    30. NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res. 2018 11; 176:243-251. Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF. PMID: 30201519; PMCID: PMC6215720.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    31. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients. Sci Rep. 2018 07 23; 8(1):11044. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF. PMID: 30038391; PMCID: PMC6056496.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    32. Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models. Sci Rep. 2018 07 02; 8(1):9919. Hawley D, Tang X, Zyrianova T, Shah M, Janga S, Letourneau A, Schicht M, Paulsen F, Hamm-Alvarez S, Makarenkova HP, Zoukhri D. PMID: 29967327; PMCID: PMC6028591.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    33. Interferon-γ treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome. PLoS One. 2017; 12(9):e0184781. Meng Z, Klinngam W, Edman MC, Hamm-Alvarez SF. PMID: 28902875; PMCID: PMC5597228.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    34. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2017; 2017:3134543. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D. PMID: 28348600; PMCID: PMC5352970.
      View in: PubMed   Mentions: 22  
    35. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. PMID: 28122086; PMCID: PMC5270623.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    36. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 06 01; 310(11):C942-54. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. PMID: 27076615; PMCID: PMC4935202.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    37. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez SF, Zandi E. PMID: 26807013; PMCID: PMC4720167.
      View in: PubMed   Mentions: 6  
    38. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 10 28; 240:93-108. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. PMID: 26578439; PMCID: PMC5767577.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    39. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA. PMID: 25523518; PMCID: PMC4456098.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    40. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. PMID: 25530855; PMCID: PMC4270104.
      View in: PubMed   Mentions: 25     Fields:    
    41. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. PMID: 25481446; PMCID: PMC4456095.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    42. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. PMID: 25419208; PMCID: PMC4235962.
      View in: PubMed   Mentions: 15  
    43. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. PMID: 24644101; PMCID: PMC4077975.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimals
    44. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. PMID: 23892265; PMCID: PMC3796004.
      View in: PubMed   Mentions: 58     Fields:    Translation:AnimalsCells
    45. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF. PMID: 23606742; PMCID: PMC3687702.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    46. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 23454523; PMCID: PMC3702651.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    47. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. Gonzalez JM, Hamm-Alvarez S, Tan JC. PMID: 23249706; PMCID: PMC3565993.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    48. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. PMID: 23088632; PMCID: PMC3500625.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    49. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. PMID: 23026636; PMCID: PMC3565049.
      View in: PubMed   Mentions: 121     Fields:    Translation:HumansAnimalsCells
    50. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. Tan JC, Gonzalez JM, Hamm-Alvarez S, Song J. PMID: 22410566; PMCID: PMC3995572.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    51. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. PMID: 22363685; PMCID: PMC3282742.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    52. Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PLoS One. 2012; 7(2):e31789. Chiang L, Karvar S, Hamm-Alvarez SF. PMID: 22363735; PMCID: PMC3282733.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    53. Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells. Cytotechnology. 2012 Mar; 64(2):149-56. Contreras J, Hsueh PY, Pei H, Hamm-Alvarez SF. PMID: 22138892; PMCID: PMC3279577.
      View in: PubMed   Mentions: 1     Fields:    
    54. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 22131830; PMCID: PMC3224711.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    55. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. PMID: 21984810; PMCID: PMC3196860.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    56. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release. 2011 Oct 30; 155(2):134-43. Contreras J, Elnagar AY, Hamm-Alvarez SF, Camarero JA. PMID: 21906641; PMCID: PMC3195939.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    57. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. PMID: 21699930; PMCID: PMC3196066.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    58. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21. Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF. PMID: 21525430; PMCID: PMC3154548.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    59. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 21310266; PMCID: PMC3130091.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    60. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 20639441; PMCID: PMC3029930.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    61. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. ACS Nano. 2010 May 25; 4(5):2735-47. Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez SF. PMID: 20420413; PMCID: PMC2948672.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    62. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF. PMID: 20463324; PMCID: PMC3066616.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    63. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. Exp Eye Res. 2010 Feb; 90(2):223-37. Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF. PMID: 19852957; PMCID: PMC2821966.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    64. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. Hamm-Alvarez S, Cadenas E. PMID: 19835920.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    65. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 19574531; PMCID: PMC2874446.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    66. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res. 2009 Sep; 89(3):319-32. Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez SF. PMID: 19345210; PMCID: PMC2720431.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    67. Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. Exp Eye Res. 2009 Mar; 88(3):467-78. Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez SF, Trousdale MD. PMID: 19056381; PMCID: PMC2656410.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    68. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P. PMID: 19079775; PMCID: PMC2600658.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    69. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. Hamm-Alvarez S, Cadenas E. PMID: 18692102.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    70. Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank. 2008 Dec; 9(4):299-307. Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K. PMID: 18431689.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    71. The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28. Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez SF. PMID: 18434623; PMCID: PMC2493552.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    72. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. PMID: 18375191.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    73. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT. PMID: 18171724; PMCID: PMC4046641.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    74. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21. Norouziyan F, Shen WC, Hamm-Alvarez SF. PMID: 17959726.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    75. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Mircheff AK, Schechter JE. PMID: 17904551; PMCID: PMC2190296.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    76. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol. 2008 Jan; 27(1):53-66. Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF. PMID: 17689946; PMCID: PMC2394184.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    77. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg. 2007 May; 83(5):1641-50. Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez SF, Stock UA, Brockbank KG, MacLellan WR. PMID: 17462373.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    78. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Schechter JE, Mircheff AK. PMID: 17164431.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    79. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. PMID: 16987972; PMCID: PMC1642591.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    80. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. Selvam S, Thomas PB, Hamm-Alvarez SF, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. PMID: 17056149; PMCID: PMC1773022.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    81. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006 May; 13(10):821-36. Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez SF, Medina-Kauwe LK. PMID: 16482205.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    82. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res. 2006 Sep; 83(3):543-53. Andersson SV, Hamm-Alvarez SF, Gierow JP. PMID: 16631165.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    83. Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. Exp Eye Res. 2006 Jul; 83(1):84-96. Wu K, Jerdeva GV, da Costa SR, Sou E, Schechter JE, Hamm-Alvarez SF. PMID: 16530759.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    84. Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice. Curr Eye Res. 2006 Jan; 31(1):13-22. Ding C, MacVeigh M, Pidgeon M, da Costa SR, Wu K, Hamm-Alvarez SF, Schechter JE. PMID: 16421015.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    85. Intracellular trafficking of nonviral vectors. Gene Ther. 2005 Dec; 12(24):1734-51. Medina-Kauwe LK, Xie J, Hamm-Alvarez S. PMID: 16079885.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    86. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. Jerdeva GV, Wu K, Yarber FA, Rhodes CJ, Kalman D, Schechter JE, Hamm-Alvarez SF. PMID: 16219687; PMCID: PMC1482462.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    87. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez SF, Schechter JE. PMID: 17131026.
      View in: PubMed   Mentions: 10     Fields:    
    88. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006 Jan; 82(1):33-45. da Costa SR, Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, Hamm-Alvarez SF. PMID: 16005870; PMCID: PMC1351294.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    89. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. PMID: 15930141; PMCID: PMC1414898.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    90. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. PMID: 15483666.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    91. Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation. Scand J Immunol. 2005 Jan; 61(1):36-50. Rose CM, Qian L, Hakim L, Wang Y, Jerdeva GY, Marchelletta R, Nakamura T, Hamm-Alvarez SF, Mircheff AK. PMID: 15644121.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    92. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez SF, Mircheff AK. PMID: 15500825.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    93. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. Chu C, Okamoto CT, Hamm-Alvarez SF, Lee VH. PMID: 15587917.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    94. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. PMID: 15029229.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    95. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. Xie J, Qian L, Wang Y, Hamm-Alvarez SF, Mircheff AK. PMID: 15109916.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    96. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez SF, Mircheff AK. PMID: 14978740.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    97. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. PMID: 14636719.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    98. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. da Costa SR, Okamoto CT, Hamm-Alvarez SF. PMID: 14597136.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    99. Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist. Scand J Immunol. 2003 Nov; 58(5):550-65. Qian L, Wang Y, Xie J, Rose CM, Yang T, Nakamura T, Sandberg M, Zeng H, Schechter JE, Chow RH, Hamm-Alvarez SF, Mircheff AK. PMID: 14629627.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    100. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. PMID: 12937279; PMCID: PMC266760.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    101. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. PMID: 12679381.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    102. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. Mircheff AK, Xie J, Qian L, Hamm-Alvarez SF. PMID: 12167246.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    103. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. PMID: 11880335.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    104. Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain". Am J Physiol Cell Physiol. 2002 Mar; 282(3):C417-9. Hamm-Alvarez SF. PMID: 11832326.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    105. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez SF. PMID: 12613888.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    106. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. Xie J, Qian L, Hamm-Alvarez SF, Mircheff AK. PMID: 12613910.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    107. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. PMID: 12613908.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    108. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez SF, Mircheff AK. PMID: 11878814.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    109. Etk/Bmx activation modulates barrier function in epithelial cells. Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1657-68. Hamm-Alvarez SF, Chang A, Wang Y, Jerdeva G, Lin HH, Kim KJ, Ann DK. PMID: 11350762.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    110. Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression. Pharm Res. 2001 Feb; 18(2):246-9. Lindberg J, Fernandez MA, Ropp JD, Hamm-Alvarez SF. PMID: 11405299.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    111. Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases. Cell Motil Cytoskeleton. 2000 Dec; 47(4):253-68. da Costa SR, Wang Y, Vilalta PM, Schönthal AH, Hamm-Alvarez SF. PMID: 11093247.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    112. Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton. Biochem Biophys Res Commun. 2000 Nov 02; 277(3):525-30. Wang Y, Duncan R, Ann DK, Hamm-Alvarez SF. PMID: 11061987.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    113. Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini. Curr Eye Res. 2000 May; 20(5):373-83. Zhang L, da Costa SR, Yarber FA, Runnegar M, Hamm-Alvarez SF. PMID: 10855032.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    114. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 01; 62(1-2):129-40. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. PMID: 10518644.
      View in: PubMed   Mentions: 11     Fields:    
    115. Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function. Biochem J. 1999 Aug 15; 342 ( Pt 1):1-6. Runnegar MT, Wei X, Hamm-Alvarez SF. PMID: 10432292; PMCID: PMC1220428.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    116. Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells. Am J Physiol. 1998 12; 275(6):C1630-9. Sonee M, Barrón E, Yarber FA, Hamm-Alvarez SF. PMID: 9843725.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    117. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VH. PMID: 9811478.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    118. Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney. Physiol Rev. 1998 Oct; 78(4):1109-29. Hamm-Alvarez SF, Sheetz MP. PMID: 9790571.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    119. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. PMID: 9735340.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    120. A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments. J Cell Sci. 1998 Jul; 111 ( Pt 13):1841-52. Vilalta PM, Zhang L, Hamm-Alvarez SF. PMID: 9625747.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    121. Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells. J Cell Sci. 1998 May; 111 ( Pt 9):1267-76. da Costa SR, Yarber FA, Zhang L, Sonee M, Hamm-Alvarez SF. PMID: 9547304.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    122. Kinesin activation drives the retrieval of secretory membranes following secretion in rabbit lacrimal acinar cells. Adv Exp Med Biol. 1998; 438:177-80. Hamm-Alvarez SF, da Costa SR, Sonee M, Warren DW, Mircheff AK. PMID: 9634883.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    123. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez SF, Okamoto CT, Bachmann M. PMID: 10076804.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    124. Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology. 1997 Jul; 26(1):176-85. Runnegar M, Wei X, Berndt N, Hamm-Alvarez SF. PMID: 9214467.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    125. Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity. Exp Eye Res. 1997 Feb; 64(2):141-56. Hamm-Alvarez SF, Da Costa S, Yang T, Wei X, Gierow JP, Mircheff AK. PMID: 9176047.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    126. Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res. 1997 Jan; 80(1):52-61. Sussman MA, Hamm-Alvarez SF, Vilalta PM, Welch S, Kedes L. PMID: 8978322.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    127. Paclitaxel and nocodazole differentially alter endocytosis in cultured cells. Pharm Res. 1996 Nov; 13(11):1647-56. Hamm-Alvarez SF, Sonee M, Loran-Goss K, Shen WC. PMID: 8956329.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    128. Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am J Physiol. 1996 Sep; 271(3 Pt 1):C929-43. Hamm-Alvarez SF, Wei X, Berndt N, Runnegar M. PMID: 8843724.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    129. Microtubule-based motor proteins: new targets for enhancing drug delivery? Pharm Res. 1996 Apr; 13(4):489-96. Hamm-Alvarez SF. PMID: 8710737.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    130. Coordinate depression of bradykinin receptor recycling and microtubule-dependent transport by taxol. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7812-6. Hamm-Alvarez SF, Alayof BE, Himmel HM, Kim PY, Crews AL, Strauss HC, Sheetz MP. PMID: 7914372; PMCID: PMC44492.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    131. Regulation of kinesin activity by phosphorylation of kinesin-associated proteins. J Biol Chem. 1994 Jul 22; 269(29):19176-82. McIlvain JM, Burkhardt JK, Hamm-Alvarez S, Argon Y, Sheetz MP. PMID: 8034676.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    132. Regulation of vesicle transport in CV-1 cells and extracts. J Cell Sci. 1993 Nov; 106 ( Pt 3):955-66. Hamm-Alvarez SF, Kim PY, Sheetz MP. PMID: 7905879.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    133. The folate cofactor of Escherichia coli DNA photolyase acts catalytically. J Biol Chem. 1990 Oct 25; 265(30):18656-62. Hamm-Alvarez S, Sancar A, Rajagopalan KV. PMID: 2211728.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    134. The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants. J Biol Chem. 1990 Jun 15; 265(17):9850-6. Hamm-Alvarez SF, Sancar A, Rajagopalan KV. PMID: 2190985.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
    135. Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase. J Biol Chem. 1989 Jun 05; 264(16):9649-56. Hamm-Alvarez S, Sancar A, Rajagopalan KV. PMID: 2656701.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    136. Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2046-50. Johnson JL, Hamm-Alvarez S, Payne G, Sancar GB, Rajagopalan KV, Sancar A. PMID: 2895469; PMCID: PMC279925.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    Sarah's Networks
    Concepts (563)
    Derived automatically from this person's publications.
    Explore
    _
    Co-Authors (34)
    People in Profiles who have published with this person.
    Explore
    _
    Similar People (60)
    People who share similar concepts with this person.
    Explore
    _
    Same Department
    Search Department
    _

    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

    This site is running Profiles RNS version UCSF-v3.1.0-6-g69de2244 on PROFILES-PWEB03. We use cookies to operate our website. We also use cookies to analyze our site’s performance and improve your experience on our site. For more information about how we use cookies, please see our Website Terms of Use.