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Sarah Hamm-Alvarez, PhD

TitleProfessor of Ophthalmology and Pharmacology and Pharmaceutical Sciences
InstitutionUniversity of Southern California
DepartmentOphthalmology
AddressMCA 346A 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
Phone+1 323 442 1445
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    Other Positions
    TitleAssociate Dean For Basic and Translational Research


    Collapse Biography 
    Collapse Education and Training
    Carleton College, Northfield, MNBA1986Chemistry
    Duke University, Durham, NCPh. D.1990Biochemistry
    Duke University, Durham, NCpostdoctoral1993Cell Biology
    Collapse Awards and Honors
    Duke University1991  - 1993Muscular Dystrophy Association Postdoctoral Fellow
    American Heart Association1994  - 1996Initial Investigatorship
    Linneaus University, Kalmar Sweden2003Doctor of Philosophy, honoris causa
    USC School of Pharmacy2003John A. Biles Professor of Pharmaceutical Sciences
    USC School of Pharmacy2004  - 2015Gavin S. Herbert Professor of Pharmaceutical Sciences
    2010  - 2011Higher Education Resource Services (HERS) Representative
    American Association of Pharmaceutical Scientists2014Fellow

    Collapse Overview 
    Collapse Overview
    Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

    An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

    Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.


    Collapse Research 
    Collapse Research Activities and Funding
    Protein-polymer nanomedicine for Sjogren's Syndrome
    NIH/NEI R01EY026635Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Protein-polymer nanomedicines for Sjogren's syndrome
    National Institutes of Health/National Eye Institute RO1EY026635-0A1Mar 1, 2017 - Feb 28, 2021
    Role: One of two multi-PI investigators with JA MacKay
    Identification of tear biomarkers for Parkinson's disease patients
    Michael J Fox Foundation Jan 1, 2017 - Dec 31, 2018
    Role: Principal Investigator
    Trafficking of plgR in Lacrimal Gland
    NIH/NEI R01EY016985Aug 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Ad5 Fiber Entry and Trafficking in Lacrimal Acini
    NIH/NEI R01EY017293Apr 3, 2006 - Mar 31, 2012
    Role: Principal Investigator
    Adenovirus Modulation of Lacrimal Gland Function
    NIH/NEI R03EY013949Apr 1, 2003 - Mar 31, 2006
    Role: Principal Investigator
    Microtubule-Based Transport in Lacrimal Gland Function
    NIH/NEI R01EY011386Jul 1, 1996 - Jun 30, 2021
    Role: Principal Investigator
    CELLULAR MECHANISMS OF TAXOL TOXICITY
    NIH/NCI R29CA063387Apr 1, 1994 - May 15, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez S. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients. Sci Rep. 2018 Jul 23; 8(1):11044. PMID: 30038391.
      View in: PubMed
    2. Hawley D, Tang X, Zyrianova T, Shah M, Janga S, Letourneau A, Schicht M, Paulsen F, Hamm-Alvarez S, Makarenkova HP, Zoukhri D. Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models. Sci Rep. 2018 Jul 02; 8(1):9919. PMID: 29967327.
      View in: PubMed
    3. Meng Z, Klinngam W, Edman MC, Hamm-Alvarez S. Interferon-? treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome. PLoS One. 2017; 12(9):e0184781. PMID: 28902875.
      View in: PubMed
    4. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez S, Zoukhri D. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2017; 2017:3134543. PMID: 28348600.
      View in: PubMed
    5. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez S. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. PMID: 28122086.
      View in: PubMed
    6. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez S. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 Jun 01; 310(11):C942-54. PMID: 27076615; PMCID: PMC4935202 [Available on 06/01/17].
    7. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez S, Zandi E. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. PMID: 26807013.
      View in: PubMed
    8. Despanie J, Dhandhukia JP, Hamm-Alvarez S, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 10 28; 240:93-108. PMID: 26578439.
      View in: PubMed
    9. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez S, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. PMID: 25523518; PMCID: PMC4456098.
    10. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez S, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. PMID: 25530855.
      View in: PubMed
    11. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez S, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. PMID: 25481446; PMCID: PMC4456095.
    12. Pastuszka MK, Okamoto CT, Hamm-Alvarez S, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
      View in: PubMed
    13. Hamm-Alvarez S, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. PMID: 24644101; PMCID: PMC4077975.
    14. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez S. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. PMID: 23892265; PMCID: PMC3796004.
    15. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez S. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742; PMCID: PMC3687702.
    16. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. PMID: 23454523; PMCID: PMC3702651.
    17. Gonzalez JM, Hamm-Alvarez S, Tan JC. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. PMID: 23249706; PMCID: PMC3565993.
    18. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632; PMCID: PMC3500625.
    19. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez S. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. PMID: 23026636; PMCID: PMC3565049.
    20. Tan JC, Gonzalez JM, Hamm-Alvarez S, Song J. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. PMID: 22410566; PMCID: PMC3995572.
    21. Chiang L, Karvar S, Hamm-Alvarez S. Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PLoS One. 2012; 7(2):e31789. PMID: 22363735; PMCID: PMC3282733.
    22. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez S, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. PMID: 22363685.
      View in: PubMed
    23. Contreras J, Hsueh PY, Pei H, Hamm-Alvarez S. Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells. Cytotechnology. 2012 Mar; 64(2):149-56. PMID: 22138892; PMCID: PMC3279577.
    24. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. PMID: 22131830; PMCID: PMC3224711.
    25. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810; PMCID: PMC3196860.
    26. Contreras J, Elnagar AY, Hamm-Alvarez S, Camarero JA. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release. 2011 Oct 30; 155(2):134-43. PMID: 21906641; PMCID: PMC3195939.
    27. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. PMID: 21699930; PMCID: PMC3196066.
    28. Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez S. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21. PMID: 21525430; PMCID: PMC3154548.
    29. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. PMID: 21310266.
      View in: PubMed
    30. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. PMID: 20639441; PMCID: PMC3029930.
    31. Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez S. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. ACS Nano. 2010 May 25; 4(5):2735-47. PMID: 20420413; PMCID: PMC2948672.
    32. Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez S. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. PMID: 20463324; PMCID: PMC3066616.
    33. Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez S. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. Exp Eye Res. 2010 Feb; 90(2):223-37. PMID: 19852957; PMCID: PMC2821966.
    34. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. PMID: 19835920.
      View in: PubMed
    35. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531; PMCID: PMC2874446.
    36. Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez S. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res. 2009 Sep; 89(3):319-32. PMID: 19345210; PMCID: PMC2720431.
    37. Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez S, Trousdale MD. Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. Exp Eye Res. 2009 Mar; 88(3):467-78. PMID: 19056381; PMCID: PMC2656410.
    38. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez S, Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62. PMID: 19079775.
      View in: PubMed
    39. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. PMID: 18692102.
      View in: PubMed
    40. Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez S. The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28. PMID: 18434623; PMCID: PMC2493552.
    41. Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez S, Chen ZZ, Schenke-Layland K. Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank. 2008 Dec; 9(4):299-307. PMID: 18431689.
      View in: PubMed
    42. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez S, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. PMID: 18375191.
      View in: PubMed
    43. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez S, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724; PMCID: PMC4046641.
    44. Norouziyan F, Shen WC, Hamm-Alvarez S. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21. PMID: 17959726.
      View in: PubMed
    45. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez S, Mircheff AK, Schechter JE. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. PMID: 17904551; PMCID: PMC2190296.
    46. Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez S. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol. 2008 Jan; 27(1):53-66. PMID: 17689946; PMCID: PMC2394184.
    47. Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez S, Stock UA, Brockbank KG, MacLellan WR. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg. 2007 May; 83(5):1641-50. PMID: 17462373.
      View in: PubMed
    48. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez S, Schechter JE, Mircheff AK. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. PMID: 17164431.
      View in: PubMed
    49. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez S. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. PMID: 16987972; PMCID: PMC1642591.
    50. Selvam S, Thomas PB, Hamm-Alvarez S, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. PMID: 17056149; PMCID: PMC1773022.
    51. Andersson SV, Hamm-Alvarez S, Gierow JP. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res. 2006 Sep; 83(3):543-53. PMID: 16631165.
      View in: PubMed
    52. Wu K, Jerdeva GV, da Costa SR, Sou E, Schechter JE, Hamm-Alvarez S. Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. Exp Eye Res. 2006 Jul; 83(1):84-96. PMID: 16530759.
      View in: PubMed
    53. Ding C, MacVeigh M, Pidgeon M, da Costa SR, Wu K, Hamm-Alvarez S, Schechter JE. Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice. Curr Eye Res. 2006 Jan; 31(1):13-22. PMID: 16421015.
      View in: PubMed
    54. Jerdeva GV, Wu K, Yarber FA, Rhodes CJ, Kalman D, Schechter JE, Hamm-Alvarez S. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. PMID: 16219687; PMCID: PMC1482462.
    55. Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez S, Schechter JE. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. PMID: 17131026.
      View in: PubMed
    56. da Costa SR, Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, Hamm-Alvarez S. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006 Jan; 82(1):33-45. PMID: 16005870; PMCID: PMC1351294.
    57. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez S. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141; PMCID: PMC1414898.
    58. Chu C, Okamoto CT, Hamm-Alvarez S, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
      View in: PubMed
    59. Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez S, Mircheff AK. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. PMID: 15500825.
      View in: PubMed
    60. Xie J, Qian L, Wang Y, Hamm-Alvarez S, Mircheff AK. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. PMID: 15109916.
      View in: PubMed
    61. Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez S, Mircheff AK. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. PMID: 14978740.
      View in: PubMed
    62. Hamm-Alvarez S, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. PMID: 14636719.
      View in: PubMed
    63. da Costa SR, Okamoto CT, Hamm-Alvarez S. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
      View in: PubMed
    64. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez S. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279; PMCID: PMC266760.
    65. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez S. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. PMID: 12679381.
      View in: PubMed
    66. Mircheff AK, Xie J, Qian L, Hamm-Alvarez S. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. PMID: 12167246.
      View in: PubMed
    67. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez S, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
      View in: PubMed
    68. Hamm-Alvarez S. Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain". Am J Physiol Cell Physiol. 2002 Mar; 282(3):C417-9. PMID: 11832326.
      View in: PubMed
    69. Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez S. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. PMID: 12613888.
      View in: PubMed
    70. Xie J, Qian L, Hamm-Alvarez S, Mircheff AK. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. PMID: 12613910.
      View in: PubMed
    71. Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez S, Mircheff AK. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. PMID: 11878814.
      View in: PubMed
    72. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
      View in: PubMed
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