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Sarah Hamm-Alvarez, PhD

Title(s)Professor of Ophthalmology and Pharmacology and Pharmaceutical Sciences
Phone+1 323 442 1445
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    Other Positions
    Title(s)Associate Dean for Basic and Translational Research


    Collapse Biography 
    Collapse Education and Training
    Carleton College, Northfield, MNBA1986Chemistry
    Duke University, Durham, NCPh. D.1990Biochemistry
    Duke University, Durham, NCpostdoctoral1993Cell Biology
    Collapse Awards and Honors
    Duke University1991  - 1993Muscular Dystrophy Association Postdoctoral Fellow
    American Heart Association1994  - 1996Initial Investigatorship
    Linneaus University, Kalmar Sweden2003Doctor of Philosophy, honoris causa
    USC School of Pharmacy2003John A. Biles Professor of Pharmaceutical Sciences
    USC School of Pharmacy2004  - 2015Gavin S. Herbert Professor of Pharmaceutical Sciences
    2010  - 2011Higher Education Resource Services (HERS) Representative
    American Association of Pharmaceutical Scientists2014Fellow

    Collapse Overview 
    Collapse Overview
    Sarah Hamm-Alvarez, PhD, is Professor of Ophthalmology and Vice Chair for Basic Research at the USC Roski Institute, and Associate Dean, Basic and Translational Sciences, USC Keck School of Medicine. Dr. Hamm-Alvarez holds a secondary faculty appointment as Professor of Pharmacology and Pharmaceutical Sciences at USC's School of Pharmacy. She also directs the Office of Research Development at the Southern California Clinical and Translational Science Institute (SC-CTSI).

    An expert in cellular membrane trafficking and high-resolution imaging, Professor Hamm-Alvarez is recognized internationally for her work on regulated exocytosis in acinar cells. Her membrane-trafficking research has sparked new growth of translational programs in her laboratory ultimately aimed at improving clinical diagnosis and treatment of SjÖgren’s syndrome, an autoimmune disease affecting the secretory function of the lacrimal gland and the integrity of the ocular surface. Other of her research programs focus on protein-targeted drug delivery. characterizing nanoparticle interactions with cells, and development of protein polymer-based drug delivery systems for ocular diseases.

    Professor Hamm-Alvarez was awarded a PhD in Biochemistry from Duke University in 1990, where she also completed a postdoctoral fellowship in Cell Biology in 1993. She has authored numerous papers, served on editorial boards and grant review committees, is an AAPS fellow, and received an Honorary Doctorate from Linneaus University in Sweden.

    Collapse Research 
    Collapse Research Activities and Funding
    Protein-polymer nanomedicine for Sjogren's Syndrome
    NIH/NEI R01EY026635Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Protein-polymer nanomedicines for Sjogren's syndrome
    National Institutes of Health/National Eye Institute RO1EY026635-0A1Mar 1, 2017 - Feb 28, 2021
    Role: One of two multi-PI investigators with JA MacKay
    Identification of tear biomarkers for Parkinson's disease patients
    Michael J Fox Foundation Jan 1, 2017 - Dec 31, 2018
    Role: Principal Investigator
    Trafficking of plgR in Lacrimal Gland
    NIH/NEI R01EY016985Aug 1, 2006 - Jun 30, 2012
    Role: Principal Investigator
    Ad5 Fiber Entry and Trafficking in Lacrimal Acini
    NIH/NEI R01EY017293Apr 3, 2006 - Mar 31, 2012
    Role: Principal Investigator
    Adenovirus Modulation of Lacrimal Gland Function
    NIH/NEI R03EY013949Apr 1, 2003 - Mar 31, 2006
    Role: Principal Investigator
    Microtubule-Based Transport in Lacrimal Gland Function
    NIH/NEI R01EY011386Jul 1, 1996 - Jun 30, 2021
    Role: Principal Investigator
    CELLULAR MECHANISMS OF TAXOL TOXICITY
    NIH/NCI R29CA063387Apr 1, 1994 - May 15, 1999
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Websites
    Collapse In The News
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Fu R, Guo H, Janga S, Choi M, Klinngam W, Edman MC, Hamm-Alvarez SF. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model. Sci Rep. 2020 Jan 29; 10(1):1455. PMID: 31996771.
      View in: PubMed
    2. Hamm-Alvarez SF, Janga SR, Edman MC, Feigenbaum D, Freire D, Mack WJ, Okamoto CT, Lew MF. Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls. Biomark Med. 2019 Dec; 13(17):1447-1457. PMID: 31552762.
      View in: PubMed
    3. Ju Y, Guo H, Yarber F, Edman MC, Peddi S, Janga SR, MacKay JA, Hamm-Alvarez SF. Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide. Bioconjug Chem. 2019 Sep 18; 30(9):2358-2372. PMID: 31408605.
      View in: PubMed
    4. Fu R, Klinngam W, Heur M, Edman MC, Hamm-Alvarez SF. Tear Proteases and Protease Inhibitors: Potential Biomarkers and Disease Drivers in Ocular Surface Disease. Eye Contact Lens. 2019 Jul 31. PMID: 31369467.
      View in: PubMed
    5. Hamm-Alvarez SF, Okamoto CT, Janga SR, Feigenbaum D, Edman MC, Freire D, Shah M, Ghanshani R, Mack WJ, Lew MF. Oligomeric a-synuclein is increased in basal tears of Parkinson's patients. Biomark Med. 2019 Aug; 13(11):941-952. PMID: 31262201.
      View in: PubMed
    6. Klinngam W, Janga SR, Lee C, Ju Y, Yarber F, Shah M, Guo H, Wang D, MacKay JA, Edman MC, Hamm-Alvarez SF. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome. Sci Rep. 2019 Jul 02; 9(1):9559. PMID: 31267034.
      View in: PubMed
    7. Janga SR, Hamm-Alvarez SF. PP2A: A Novel Target to Prevent Cathepsin S-mediated Damage in Smoking-induced Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 Jul 01; 200(1):6-8. PMID: 30785780.
      View in: PubMed
    8. Lee C, Guo H, Klinngam W, Janga SR, Yarber F, Peddi S, Edman MC, Tiwari N, Liu S, Louie SG, Hamm-Alvarez SF, MacKay JA. Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. Mol Pharm. 2019 Jul 01; 16(7):3024-3039. PMID: 31095909.
      View in: PubMed
    9. Klinngam W, Fu R, Janga SR, Edman MC, Hamm-Alvarez SF. Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells. Int J Mol Sci. 2018 Nov 09; 19(11). PMID: 30423938.
      View in: PubMed
    10. Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA. A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. J Control Release. 2018 12 28; 292:183-195. PMID: 30359668.
      View in: PubMed
    11. Janga SR, Shah M, Ju Y, Meng Z, Edman MC, Hamm-Alvarez SF. Longitudinal analysis of tear cathepsin S activity levels in male non-obese diabetic mice suggests its potential as an early stage biomarker of Sjögren's Syndrome. Biomarkers. 2019 Feb; 24(1):91-102. PMID: 30126300.
      View in: PubMed
    12. Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF. NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res. 2018 11; 176:243-251. PMID: 30201519.
      View in: PubMed
    13. Edman MC, Janga SR, Meng Z, Bechtold M, Chen AF, Kim C, Naman L, Sarma A, Teekappanavar N, Kim AY, Madrigal S, Singh S, Ortiz E, Christianakis S, Arkfeld DG, Mack WJ, Heur M, Stohl W, Hamm-Alvarez SF. Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren's Syndrome patients. Sci Rep. 2018 07 23; 8(1):11044. PMID: 30038391.
      View in: PubMed
    14. Hawley D, Tang X, Zyrianova T, Shah M, Janga S, Letourneau A, Schicht M, Paulsen F, Hamm-Alvarez S, Makarenkova HP, Zoukhri D. Myoepithelial cell-driven acini contraction in response to oxytocin receptor stimulation is impaired in lacrimal glands of Sjögren's syndrome animal models. Sci Rep. 2018 07 02; 8(1):9919. PMID: 29967327.
      View in: PubMed
    15. Meng Z, Klinngam W, Edman MC, Hamm-Alvarez SF. Interferon-? treatment in vitro elicits some of the changes in cathepsin S and antigen presentation characteristic of lacrimal glands and corneas from the NOD mouse model of Sjögren's Syndrome. PLoS One. 2017; 12(9):e0184781. PMID: 28902875.
      View in: PubMed
    16. Aluri HS, Samizadeh M, Edman MC, Hawley DR, Armaos HL, Janga SR, Meng Z, Sendra VG, Hamrah P, Kublin CL, Hamm-Alvarez SF, Zoukhri D. Delivery of Bone Marrow-Derived Mesenchymal Stem Cells Improves Tear Production in a Mouse Model of Sjögren's Syndrome. Stem Cells Int. 2017; 2017:3134543. PMID: 28348600.
      View in: PubMed
    17. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. PMID: 28122086.
      View in: PubMed
    18. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 06 01; 310(11):C942-54. PMID: 27076615.
      View in: PubMed
    19. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez SF, Zandi E. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. PMID: 26807013.
      View in: PubMed
    20. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 10 28; 240:93-108. PMID: 26578439.
      View in: PubMed
    21. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. PMID: 25523518.
      View in: PubMed
    22. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. PMID: 25530855.
      View in: PubMed
    23. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. PMID: 25481446.
      View in: PubMed
    24. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
      View in: PubMed
    25. Hamm-Alvarez SF, Janga SR, Edman MC, Madrigal S, Shah M, Frousiakis SE, Renduchintala K, Zhu J, Bricel S, Silka K, Bach D, Heur M, Christianakis S, Arkfeld DG, Irvine J, Mack WJ, Stohl W. Tear cathepsin S as a candidate biomarker for Sjögren's syndrome. Arthritis Rheumatol. 2014 Jul; 66(7):1872-81. PMID: 24644101.
      View in: PubMed
    26. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. PMID: 23892265.
      View in: PubMed
    27. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742.
      View in: PubMed
    28. Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms. Nanomedicine. 2013 Aug; 9(6):786-94. PMID: 23454523.
      View in: PubMed
    29. Gonzalez JM, Hamm-Alvarez S, Tan JC. Analyzing live cellularity in the human trabecular meshwork. Invest Ophthalmol Vis Sci. 2013 Feb 05; 54(2):1039-47. PMID: 23249706.
      View in: PubMed
    30. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632.
      View in: PubMed
    31. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. PMID: 23026636.
      View in: PubMed
    32. Tan JC, Gonzalez JM, Hamm-Alvarez S, Song J. In situ autofluorescence visualization of human trabecular meshwork structure. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2080-8. PMID: 22410566.
      View in: PubMed
    33. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. PMID: 22363685.
      View in: PubMed
    34. Chiang L, Karvar S, Hamm-Alvarez SF. Direct imaging of RAB27B-enriched secretory vesicle biogenesis in lacrimal acinar cells reveals origins on a nascent vesicle budding site. PLoS One. 2012; 7(2):e31789. PMID: 22363735.
      View in: PubMed
    35. Contreras J, Hsueh PY, Pei H, Hamm-Alvarez SF. Use of nucleofection to efficiently transfect primary rabbit lacrimal gland acinar cells. Cytotechnology. 2012 Mar; 64(2):149-56. PMID: 22138892.
      View in: PubMed
    36. Fazlollahi F, Sipos A, Kim YH, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Translocation of PEGylated quantum dots across rat alveolar epithelial cell monolayers. Int J Nanomedicine. 2011; 6:2849-57. PMID: 22131830.
      View in: PubMed
    37. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810.
      View in: PubMed
    38. Contreras J, Elnagar AY, Hamm-Alvarez SF, Camarero JA. Cellular uptake of cyclotide MCoTI-I follows multiple endocytic pathways. J Control Release. 2011 Oct 30; 155(2):134-43. PMID: 21906641.
      View in: PubMed
    39. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. PMID: 21699930.
      View in: PubMed
    40. Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF. Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C507-21. PMID: 21525430.
      View in: PubMed
    41. Fazlollahi F, Angelow S, Yacobi NR, Marchelletta R, Yu AS, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across MDCK-II. Nanomedicine. 2011 Oct; 7(5):588-94. PMID: 21310266.
      View in: PubMed
    42. Kim YH, Fazlollahi F, Kennedy IM, Yacobi NR, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Alveolar epithelial cell injury due to zinc oxide nanoparticle exposure. Am J Respir Crit Care Med. 2010 Dec 01; 182(11):1398-409. PMID: 20639441.
      View in: PubMed
    43. Contreras J, Xie J, Chen YJ, Pei H, Zhang G, Fraser CL, Hamm-Alvarez SF. Intracellular uptake and trafficking of difluoroboron dibenzoylmethane-polylactide nanoparticles in HeLa cells. ACS Nano. 2010 May 25; 4(5):2735-47. PMID: 20420413.
      View in: PubMed
    44. Li X, Wu K, Edman M, Schenke-Layland K, MacVeigh-Aloni M, Janga SR, Schulz B, Hamm-Alvarez SF. Increased expression of cathepsins and obesity-induced proinflammatory cytokines in lacrimal glands of male NOD mouse. Invest Ophthalmol Vis Sci. 2010 Oct; 51(10):5019-29. PMID: 20463324.
      View in: PubMed
    45. Schenke-Layland K, Xie J, Magnusson M, Angelis E, Li X, Wu K, Reinhardt DP, Maclellan WR, Hamm-Alvarez SF. Lymphocytic infiltration leads to degradation of lacrimal gland extracellular matrix structures in NOD mice exhibiting a Sjögren's syndrome-like exocrinopathy. Exp Eye Res. 2010 Feb; 90(2):223-37. PMID: 19852957.
      View in: PubMed
    46. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. PMID: 19835920.
      View in: PubMed
    47. Yacobi NR, Malmstadt N, Fazlollahi F, DeMaio L, Marchelletta R, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Mechanisms of alveolar epithelial translocation of a defined population of nanoparticles. Am J Respir Cell Mol Biol. 2010 May; 42(5):604-14. PMID: 19574531.
      View in: PubMed
    48. Wu K, Joffre C, Li X, MacVeigh-Aloni M, Hom M, Hwang J, Ding C, Gregoire S, Bretillon L, Zhong JF, Hamm-Alvarez SF. Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland. Exp Eye Res. 2009 Sep; 89(3):319-32. PMID: 19345210.
      View in: PubMed
    49. Xie J, Marchelletta RR, Thomas PB, Jacobs DT, Yarber FA, Cheney RE, Hamm-Alvarez SF, Trousdale MD. Transduced viral IL-10 is exocytosed from lacrimal acinar secretory vesicles in a myosin-dependent manner in response to carbachol. Exp Eye Res. 2009 Mar; 88(3):467-78. PMID: 19056381.
      View in: PubMed
    50. Joo KI, Lei Y, Lee CL, Lo J, Xie J, Hamm-Alvarez SF, Wang P. Site-specific labeling of enveloped viruses with quantum dots for single virus tracking. ACS Nano. 2008 Aug; 2(8):1553-62. PMID: 19079775.
      View in: PubMed
    51. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. PMID: 18692102.
      View in: PubMed
    52. Brockbank KG, MacLellan WR, Xie J, Hamm-Alvarez SF, Chen ZZ, Schenke-Layland K. Quantitative second harmonic generation imaging of cartilage damage. Cell Tissue Bank. 2008 Dec; 9(4):299-307. PMID: 18431689.
      View in: PubMed
    53. Marchelletta RR, Jacobs DT, Schechter JE, Cheney RE, Hamm-Alvarez SF. The class V myosin motor, myosin 5c, localizes to mature secretory vesicles and facilitates exocytosis in lacrimal acini. Am J Physiol Cell Physiol. 2008 Jul; 295(1):C13-28. PMID: 18434623.
      View in: PubMed
    54. Yacobi NR, Demaio L, Xie J, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED. Polystyrene nanoparticle trafficking across alveolar epithelium. Nanomedicine. 2008 Jun; 4(2):139-45. PMID: 18375191.
      View in: PubMed
    55. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724.
      View in: PubMed
    56. Norouziyan F, Shen WC, Hamm-Alvarez SF. Tyrphostin A8 stimulates a novel trafficking pathway of apically endocytosed transferrin through Rab11-enriched compartments in Caco-2 cells. Am J Physiol Cell Physiol. 2008 Jan; 294(1):C7-21. PMID: 17959726.
      View in: PubMed
    57. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Mircheff AK, Schechter JE. Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells. Exp Eye Res. 2007 Dec; 85(6):749-61. PMID: 17904551.
      View in: PubMed
    58. Schenke-Layland K, Xie J, Angelis E, Starcher B, Wu K, Riemann I, MacLellan WR, Hamm-Alvarez SF. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjögren's syndrome. Matrix Biol. 2008 Jan; 27(1):53-66. PMID: 17689946.
      View in: PubMed
    59. Schenke-Layland K, Xie J, Heydarkhan-Hagvall S, Hamm-Alvarez SF, Stock UA, Brockbank KG, MacLellan WR. Optimized preservation of extracellular matrix in cardiac tissues: implications for long-term graft durability. Ann Thorac Surg. 2007 May; 83(5):1641-50. PMID: 17462373.
      View in: PubMed
    60. Wang Y, Chiu CT, Nakamura T, Walker AM, Petridou B, Trousdale MD, Hamm-Alvarez SF, Schechter JE, Mircheff AK. Elevated prolactin redirects secretory vesicle traffic in rabbit lacrimal acinar cells. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1122-34. PMID: 17164431.
      View in: PubMed
    61. Xie J, Chiang L, Contreras J, Wu K, Garner JA, Medina-Kauwe L, Hamm-Alvarez SF. Novel fiber-dependent entry mechanism for adenovirus serotype 5 in lacrimal acini. J Virol. 2006 Dec; 80(23):11833-51. PMID: 16987972.
      View in: PubMed
    62. Selvam S, Thomas PB, Hamm-Alvarez SF, Schechter JE, Stevenson D, Mircheff AK, Trousdale MD. Current status of gene delivery and gene therapy in lacrimal gland using viral vectors. Adv Drug Deliv Rev. 2006 Nov 15; 58(11):1243-57. PMID: 17056149.
      View in: PubMed
    63. Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez SF, Medina-Kauwe LK. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006 May; 13(10):821-36. PMID: 16482205.
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    64. Andersson SV, Hamm-Alvarez SF, Gierow JP. Integrin adhesion in regulation of lacrimal gland acinar cell secretion. Exp Eye Res. 2006 Sep; 83(3):543-53. PMID: 16631165.
      View in: PubMed
    65. Wu K, Jerdeva GV, da Costa SR, Sou E, Schechter JE, Hamm-Alvarez SF. Molecular mechanisms of lacrimal acinar secretory vesicle exocytosis. Exp Eye Res. 2006 Jul; 83(1):84-96. PMID: 16530759.
      View in: PubMed
    66. Ding C, MacVeigh M, Pidgeon M, da Costa SR, Wu K, Hamm-Alvarez SF, Schechter JE. Unique ultrastructure of exorbital lacrimal glands in male NOD and BALB/c mice. Curr Eye Res. 2006 Jan; 31(1):13-22. PMID: 16421015.
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    67. Medina-Kauwe LK, Xie J, Hamm-Alvarez S. Intracellular trafficking of nonviral vectors. Gene Ther. 2005 Dec; 12(24):1734-51. PMID: 16079885.
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    68. Jerdeva GV, Wu K, Yarber FA, Rhodes CJ, Kalman D, Schechter JE, Hamm-Alvarez SF. Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells. J Cell Sci. 2005 Oct 15; 118(Pt 20):4797-812. PMID: 16219687.
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    69. Mircheff AK, Wang Y, Jean Mde S, Ding C, Trousdale MD, Hamm-Alvarez SF, Schechter JE. Mucosal immunity and self-tolerance in the ocular surface system. Ocul Surf. 2005 Oct; 3(4):182-92. PMID: 17131026.
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    70. da Costa SR, Wu K, Veigh MM, Pidgeon M, Ding C, Schechter JE, Hamm-Alvarez SF. Male NOD mouse external lacrimal glands exhibit profound changes in the exocytotic pathway early in postnatal development. Exp Eye Res. 2006 Jan; 82(1):33-45. PMID: 16005870.
      View in: PubMed
    71. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141.
      View in: PubMed
    72. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. PMID: 15483666.
      View in: PubMed
    73. Rose CM, Qian L, Hakim L, Wang Y, Jerdeva GY, Marchelletta R, Nakamura T, Hamm-Alvarez SF, Mircheff AK. Accumulation of catalytically active proteases in lacrimal gland acinar cell endosomes during chronic ex vivo muscarinic receptor stimulation. Scand J Immunol. 2005 Jan; 61(1):36-50. PMID: 15644121.
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    74. Qian L, Xie J, Rose CM, Sou E, Zeng H, Hamm-Alvarez SF, Mircheff AK. Altered traffic to the lysosome in an ex vivo lacrimal acinar cell model for chronic muscarinic receptor stimulation. Exp Eye Res. 2004 Nov; 79(5):665-75. PMID: 15500825.
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    75. Chu C, Okamoto CT, Hamm-Alvarez SF, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
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    76. Wang Y, Xie J, Yarber FA, Mazurek C, Trousdale MD, Medina-Kauwe LK, Kasahara N, Hamm-Alvarez SF. Adenoviral capsid modulates secretory compartment organization and function in acinar epithelial cells from rabbit lacrimal gland. Gene Ther. 2004 Jun; 11(12):970-81. PMID: 15029229.
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    77. Xie J, Qian L, Wang Y, Hamm-Alvarez SF, Mircheff AK. Role of the microtubule cytoskeleton in traffic of EGF through the lacrimal acinar cell endomembrane network. Exp Eye Res. 2004 Jun; 78(6):1093-106. PMID: 15109916.
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    78. Xie J, Qian L, Wang Y, Rose CM, Yang T, Nakamura T, Hamm-Alvarez SF, Mircheff AK. Novel biphasic traffic of endocytosed EGF to recycling and degradative compartments in lacrimal gland acinar cells. J Cell Physiol. 2004 Apr; 199(1):108-25. PMID: 14978740.
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    79. Hamm-Alvarez SF, Xie J, Wang Y, Medina-Kauwe LK. Modulation of secretory functions in epithelia by adenovirus capsid proteins. J Control Release. 2003 Dec 05; 93(2):129-40. PMID: 14636719.
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    80. da Costa SR, Okamoto CT, Hamm-Alvarez SF. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
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    81. Qian L, Wang Y, Xie J, Rose CM, Yang T, Nakamura T, Sandberg M, Zeng H, Schechter JE, Chow RH, Hamm-Alvarez SF, Mircheff AK. Biochemical changes contributing to functional quiescence in lacrimal gland acinar cells after chronic ex vivo exposure to a muscarinic agonist. Scand J Immunol. 2003 Nov; 58(5):550-65. PMID: 14629627.
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    82. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279.
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    83. Wang Y, Jerdeva G, Yarber FA, da Costa SR, Xie J, Qian L, Rose CM, Mazurek C, Kasahara N, Mircheff AK, Hamm-Alvarez SF. Cytoplasmic dynein participates in apically targeted stimulated secretory traffic in primary rabbit lacrimal acinar epithelial cells. J Cell Sci. 2003 May 15; 116(Pt 10):2051-65. PMID: 12679381.
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    84. Mircheff AK, Xie J, Qian L, Hamm-Alvarez SF. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002 May-Jun; 21(5-6):435-42. PMID: 12167246.
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    85. Yang L, Leong PK, Chen JO, Patel N, Hamm-Alvarez SF, McDonough AA. Acute hypertension provokes internalization of proximal tubule NHE3 without inhibition of transport activity. Am J Physiol Renal Physiol. 2002 Apr; 282(4):F730-40. PMID: 11880335.
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    86. Hamm-Alvarez SF. Focus on "EGF receptor downregulation depends on a trafficking motif in the distal tyrosine kinase domain". Am J Physiol Cell Physiol. 2002 Mar; 282(3):C417-9. PMID: 11832326.
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    87. Xie J, Qian L, Hamm-Alvarez SF, Mircheff AK. Epidermal growth factor traffic in lacrimal acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):213-7. PMID: 12613910.
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    88. Qian L, Yang T, Chen H, Xie J, Zeng H, Warren DW, MacVeigh M, Meneray MA, Hamm-Alvarez SF, Mircheff AK. Heterotrimeric GTP-binding proteins in the lacrimal acinar cell endomembrane system. Exp Eye Res. 2002 Jan; 74(1):7-22. PMID: 11878814.
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    89. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
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    90. Mircheff AK, Qian L, Xie J, Wang Y, Hamm-Alvarez SF. M3 receptor autoimmunity: losing tolerance to a familiar protein. Adv Exp Med Biol. 2002; 506(Pt A):51-8. PMID: 12613888.
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    91. Hamm-Alvarez SF, Chang A, Wang Y, Jerdeva G, Lin HH, Kim KJ, Ann DK. Etk/Bmx activation modulates barrier function in epithelial cells. Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1657-68. PMID: 11350762.
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    92. Lindberg J, Fernandez MA, Ropp JD, Hamm-Alvarez SF. Nocodazole treatment of CV-1 cells enhances nuclear/perinuclear accumulation of lipid-DNA complexes and increases gene expression. Pharm Res. 2001 Feb; 18(2):246-9. PMID: 11405299.
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    93. da Costa SR, Wang Y, Vilalta PM, Schönthal AH, Hamm-Alvarez SF. Changes in cytoskeletal organization in polyoma middle T antigen-transformed fibroblasts: involvement of protein phosphatase 2A and src tyrosine kinases. Cell Motil Cytoskeleton. 2000 Dec; 47(4):253-68. PMID: 11093247.
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    94. Wang Y, Duncan R, Ann DK, Hamm-Alvarez SF. Identification of a novel taxol-sensitive kinase activity associated with the cytoskeleton. Biochem Biophys Res Commun. 2000 Nov 02; 277(3):525-30. PMID: 11061987.
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    95. Zhang L, da Costa SR, Yarber FA, Runnegar M, Hamm-Alvarez SF. Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini. Curr Eye Res. 2000 May; 20(5):373-83. PMID: 10855032.
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    96. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 01; 62(1-2):129-40. PMID: 10518644.
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    97. Runnegar MT, Wei X, Hamm-Alvarez SF. Increased protein phosphorylation of cytoplasmic dynein results in impaired motor function. Biochem J. 1999 Aug 15; 342 ( Pt 1):1-6. PMID: 10432292.
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    98. Sonee M, Barrón E, Yarber FA, Hamm-Alvarez SF. Taxol inhibits endosomal-lysosomal membrane trafficking at two distinct steps in CV-1 cells. Am J Physiol. 1998 12; 275(6):C1630-9. PMID: 9843725.
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    99. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VH. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. PMID: 9811478.
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    100. Hamm-Alvarez SF, Sheetz MP. Microtubule-dependent vesicle transport: modulation of channel and transporter activity in liver and kidney. Physiol Rev. 1998 Oct; 78(4):1109-29. PMID: 9790571.
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    101. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. PMID: 9735340.
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    102. Vilalta PM, Zhang L, Hamm-Alvarez SF. A novel taxol-induced vimentin phosphorylation and stabilization revealed by studies on stable microtubules and vimentin intermediate filaments. J Cell Sci. 1998 Jul; 111 ( Pt 13):1841-52. PMID: 9625747.
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    103. da Costa SR, Yarber FA, Zhang L, Sonee M, Hamm-Alvarez SF. Microtubules facilitate the stimulated secretion of beta-hexosaminidase in lacrimal acinar cells. J Cell Sci. 1998 May; 111 ( Pt 9):1267-76. PMID: 9547304.
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    104. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez SF, Okamoto CT, Bachmann M. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. PMID: 10076804.
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    105. Hamm-Alvarez SF, da Costa SR, Sonee M, Warren DW, Mircheff AK. Kinesin activation drives the retrieval of secretory membranes following secretion in rabbit lacrimal acinar cells. Adv Exp Med Biol. 1998; 438:177-80. PMID: 9634883.
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    106. Runnegar M, Wei X, Berndt N, Hamm-Alvarez SF. Transferrin receptor recycling in rat hepatocytes is regulated by protein phosphatase 2A, possibly through effects on microtubule-dependent transport. Hepatology. 1997 Jul; 26(1):176-85. PMID: 9214467.
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    107. Hamm-Alvarez SF, Da Costa S, Yang T, Wei X, Gierow JP, Mircheff AK. Cholinergic stimulation of lacrimal acinar cells promotes redistribution of membrane-associated kinesin and the secretory protein, beta-hexosaminidase, and increases kinesin motor activity. Exp Eye Res. 1997 Feb; 64(2):141-56. PMID: 9176047.
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    108. Sussman MA, Hamm-Alvarez SF, Vilalta PM, Welch S, Kedes L. Involvement of phosphorylation in doxorubicin-mediated myofibril degeneration. An immunofluorescence microscopy analysis. Circ Res. 1997 Jan; 80(1):52-61. PMID: 8978322.
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    109. Hamm-Alvarez SF, Sonee M, Loran-Goss K, Shen WC. Paclitaxel and nocodazole differentially alter endocytosis in cultured cells. Pharm Res. 1996 Nov; 13(11):1647-56. PMID: 8956329.
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    110. Hamm-Alvarez SF, Wei X, Berndt N, Runnegar M. Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am J Physiol. 1996 Sep; 271(3 Pt 1):C929-43. PMID: 8843724.
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    111. Hamm-Alvarez SF. Microtubule-based motor proteins: new targets for enhancing drug delivery? Pharm Res. 1996 Apr; 13(4):489-96. PMID: 8710737.
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    112. Hamm-Alvarez SF, Alayof BE, Himmel HM, Kim PY, Crews AL, Strauss HC, Sheetz MP. Coordinate depression of bradykinin receptor recycling and microtubule-dependent transport by taxol. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7812-6. PMID: 7914372.
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    113. McIlvain JM, Burkhardt JK, Hamm-Alvarez S, Argon Y, Sheetz MP. Regulation of kinesin activity by phosphorylation of kinesin-associated proteins. J Biol Chem. 1994 Jul 22; 269(29):19176-82. PMID: 8034676.
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    114. Hamm-Alvarez SF, Kim PY, Sheetz MP. Regulation of vesicle transport in CV-1 cells and extracts. J Cell Sci. 1993 Nov; 106 ( Pt 3):955-66. PMID: 7905879.
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    115. Hamm-Alvarez S, Sancar A, Rajagopalan KV. The folate cofactor of Escherichia coli DNA photolyase acts catalytically. J Biol Chem. 1990 Oct 25; 265(30):18656-62. PMID: 2211728.
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    116. Hamm-Alvarez SF, Sancar A, Rajagopalan KV. The presence and distribution of reduced folates in Escherichia coli dihydrofolate reductase mutants. J Biol Chem. 1990 Jun 15; 265(17):9850-6. PMID: 2190985.
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    117. Hamm-Alvarez S, Sancar A, Rajagopalan KV. Role of enzyme-bound 5,10-methenyltetrahydropteroylpolyglutamate in catalysis by Escherichia coli DNA photolyase. J Biol Chem. 1989 Jun 05; 264(16):9649-56. PMID: 2656701.
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    118. Johnson JL, Hamm-Alvarez S, Payne G, Sancar GB, Rajagopalan KV, Sancar A. Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2046-50. PMID: 2895469.
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