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Enrique Cadenas, MD, PhD

TitleProfessor
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 612
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1418
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    Collapse Overview 
    Collapse Overview
    Dr. Cadenas received his M.D. and Ph.D. degrees from the University of Buenos Aires. He served as a research fellow at the Universities of Dundee (Scotland), Pennsylvania (USA) and Dusseldorf (Germany). Prior to coming to USC in 1989, Dr. Cadenas was an associate professor of pathology at the University of Linkoping (Sweden). Currently, he is a professor of molecular pharmacology and toxicology (USC School of Pharmacy) and professor of biochemistry (USC Keck School of Medicine).

    Research Interests:

    The anomalous regulation of apoptosis has been recognized as a pathological process that occurs in a variety of conditions comprising neurodegenerative diseases, autoimmune disorders, and various cancers. We are interested in elucidating the molecular mechanisms underlying cell signaling pathways inherent in mitochondrion-dependent apoptosis and with implications for neurodegenerative- and age-related disorders.

    Ongoing research projects within these long-term goals are: (a) the study of the potential biological role of mitochondria as an important cellular target of pro-apoptotic JNK signalling involving modulation of Bcl-2 family members; (b) the regulation of mitochondrial functions by nitric oxide and the mitochondrial nitric oxide synthase and how they impinge on the cellular redox state; (c) analysis of the mitochondrial proteome for post-translational modifications caused by JNK activity and exposure to oxidative and nitrosative stress; (d) the analysis of the mechanism of actions of neuroprotective agents in terms of preserving mitochondrion functional integrity through activation of ligand-independent signaling pathways and universal transcription factors.


    Collapse Research 
    Collapse Research Activities and Funding
    2013 Oxidative Stress and Disease Gordon Research Conference &Seminar
    NIH/NIA R13AG044908Mar 15, 2013 - Feb 28, 2014
    Role: Principal Investigator
    XIIIth Biennial Meeting of the Society for Free Radical Research International
    NIH/NCI R13CA124282Aug 1, 2006 - Jul 31, 2007
    Role: Principal Investigator
    Mitochondrial oxidative damage in dopaminergic cells
    NIH/NIEHS R01ES011342Jul 11, 2001 - Jun 30, 2007
    Role: Principal Investigator
    Oxidative Stress, Mitochondrial Dysfunction and Aging
    NIH/NIA R01AG016718Apr 1, 1999 - May 31, 2011
    Role: Principal Investigator
    BIOCHEMICAL TOXICOLOGY OF MYOGLOBIN OXIDATION STATES
    NIH/NHLBI R01HL053467Jul 1, 1995 - Jun 30, 1999
    Role: Principal Investigator
    MODULATION OF QUINONE TOXICITY BY TWO-ELECTRON TRANSFERS
    NIH/NIEHS R01ES005423Jul 1, 1990 - Jun 30, 1996
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. PMID: 29270905.
      View in: PubMed
    2. Liu Z, Patil I, Sancheti H, Yin F, Cadenas E. Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and 13C-NMR Study. Sci Rep. 2017 Jul 14; 7(1):5391. PMID: 28710347.
      View in: PubMed
    3. Yin F, Yao J, Brinton RD, Cadenas E. Editorial: The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration. Front Aging Neurosci. 2017; 9:209. PMID: 28701949.
      View in: PubMed
    4. McDougall M, Choi J, Kim HK, Bobe G, Stevens JF, Cadenas E, Tanguay R, Traber MG. Lipid quantitation and metabolomics data from vitamin E-deficient and -sufficient zebrafish embryos from 0 to 120 hours-post-fertilization. Data Brief. 2017 Apr; 11:432-441. PMID: 28280764.
      View in: PubMed
    5. McDougall M, Choi J, Kim HK, Bobe G, Stevens JF, Cadenas E, Tanguay R, Traber MG. Lethal dysregulation of energy metabolism during embryonic vitamin E deficiency. Free Radic Biol Med. 2017 03; 104:324-332. PMID: 28095320.
      View in: PubMed
    6. Han D, Johnson HS, Rao MP, Martin G, Sancheti H, Silkwood KH, Decker CW, Nguyen KT, Casian JG, Cadenas E, Kaplowitz N. Mitochondrial remodeling in the liver following chronic alcohol feeding to rats. Free Radic Biol Med. 2017 01; 102:100-110. PMID: 27867097.
      View in: PubMed
    7. Bolaños JP, Cadenas E, Duchen MR, Hampton MB, Mann GE, Murphy MP. Introduction to Special Issue on Mitochondrial Redox Signaling in Health and Disease. Free Radic Biol Med. 2016 11; 100:1-4. PMID: 27502830.
      View in: PubMed
    8. Yin F, Sancheti H, Patil I, Cadenas E. Energy metabolism and inflammation in brain aging and Alzheimer's disease. Free Radic Biol Med. 2016 11; 100:108-122. PMID: 27154981.
      View in: PubMed
    9. Cadenas E, Packer L, Traber MG. Antioxidants, oxidants, and redox impacts on cell function - A tribute to Helmut Sies. Arch Biochem Biophys. 2016 Apr 01; 595:94-9. PMID: 27095223.
      View in: PubMed
    10. Murali K, Kang D, Nazari H, Scianmarello N, Cadenas E, Tai YC, Kashani A, Humayun M. Spatial Variations in Vitreous Oxygen Consumption. PLoS One. 2016; 11(3):e0149961. PMID: 26930281; PMCID: PMC4773158.
    11. Yu R, Deochand C, Krotow A, Leão R, Tong M, Agarwal AR, Cadenas E, de la Monte SM. Tobacco Smoke-Induced Brain White Matter Myelin Dysfunction: Potential Co-Factor Role of Smoking in Neurodegeneration. J Alzheimers Dis. 2016; 50(1):133-48. PMID: 26639972.
      View in: PubMed
    12. Deochand C, Tong M, Agarwal AR, Cadenas E, de la Monte SM. Tobacco Smoke Exposure Impairs Brain Insulin/IGF Signaling: Potential Co-Factor Role in Neurodegeneration. J Alzheimers Dis. 2016; 50(2):373-86. PMID: 26682684.
      View in: PubMed
    13. Nunez K, Kay J, Krotow A, Tong M, Agarwal AR, Cadenas E, de la Monte SM. Cigarette Smoke-Induced Alterations in Frontal White Matter Lipid Profiles Demonstrated by MALDI-Imaging Mass Spectrometry: Relevance to Alzheimer's Disease. J Alzheimers Dis. 2016; 51(1):151-63. PMID: 26836183.
      View in: PubMed
    14. Yin F, Sancheti H, Liu Z, Cadenas E. Mitochondrial function in ageing: coordination with signalling and transcriptional pathways. J Physiol. 2016 Apr 15; 594(8):2025-42. PMID: 26293414; PMCID: PMC4933098 [Available on 04/15/17].
    15. Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles BL, Yin F, Cadenas E. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274. PMID: 26023930.
      View in: PubMed
    16. Brinton RD, Yao J, Yin F, Mack WJ, Cadenas E. Perimenopause as a neurological transition state. Nat Rev Endocrinol. 2015 Jul; 11(7):393-405. PMID: 26007613.
      View in: PubMed
    17. Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiol Aging. 2015 Jul; 36(7):2282-2295. PMID: 25921624; PMCID: PMC4416218.
    18. Yin F, Cadenas E. Mitochondria: the cellular hub of the dynamic coordinated network. Antioxid Redox Signal. 2015 Apr 20; 22(12):961-4. PMID: 25746686; PMCID: PMC4390188.
    19. Cadenas E, Packer L. Preface. Methods Enzymol. 2015; 554:xv. PMID: 25725528.
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    20. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. PMID: 25314656.
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    21. Cadenas E, Packer L. Methods in Enzymology. Hydrogen sulfide in redox biology, part B. Preface. Methods Enzymol. 2015; 555:xv. PMID: 25747487.
      View in: PubMed
    22. Jiang T, Cadenas E. Astrocytic metabolic and inflammatory changes as a function of age. Aging Cell. 2014 Dec; 13(6):1059-67. PMID: 25233945; PMCID: PMC4244278.
    23. Sancheti H, Patil I, Kanamori K, Díaz Brinton R, Zhang W, Lin AL, Cadenas E. Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study. J Cereb Blood Flow Metab. 2014 Nov; 34(11):1749-60. PMID: 25099753; PMCID: PMC4269751.
    24. Agarwal AR, Yin F, Cadenas E. Short-term cigarette smoke exposure leads to metabolic alterations in lung alveolar cells. Am J Respir Cell Mol Biol. 2014 Aug; 51(2):284-93. PMID: 24625219.
      View in: PubMed
    25. Lourenço CF, Santos RM, Barbosa RM, Cadenas E, Radi R, Laranjinha J. Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide. Free Radic Biol Med. 2014 Aug; 73:421-9. PMID: 24887095.
      View in: PubMed
    26. Chang AH, Sancheti H, Garcia J, Kaplowitz N, Cadenas E, Han D. Respiratory substrates regulate S-nitrosylation of mitochondrial proteins through a thiol-dependent pathway. Chem Res Toxicol. 2014 May 19; 27(5):794-804. PMID: 24716714; PMCID: PMC4033640.
    27. Li B, Iglesias-Pedraz JM, Chen LY, Yin F, Cadenas E, Reddy S, Comai L. Downregulation of the Werner syndrome protein induces a metabolic shift that compromises redox homeostasis and limits proliferation of cancer cells. Aging Cell. 2014 Apr; 13(2):367-78. PMID: 24757718; PMCID: PMC3999508.
    28. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. PMID: 24508265.
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    29. Sancheti H, Kanamori K, Patil I, Díaz Brinton R, Ross BD, Cadenas E. Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. J Cereb Blood Flow Metab. 2014 Feb; 34(2):288-96. PMID: 24220168; PMCID: PMC3915206.
    30. Agarwal AR, Yin F, Cadenas E. Metabolic shift in lung alveolar cell mitochondria following acrolein exposure. Am J Physiol Lung Cell Mol Physiol. 2013 Nov 15; 305(10):L764-73. PMID: 24056970.
      View in: PubMed
    31. Jiang T, Yin F, Yao J, Brinton RD, Cadenas E. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1a transcriptional pathway. Aging Cell. 2013 Dec; 12(6):1021-31. PMID: 23815272; PMCID: PMC3819405.
    32. Sancheti H, Akopian G, Yin F, Brinton RD, Walsh JP, Cadenas E. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PLoS One. 2013; 8(7):e69830. PMID: 23875003; PMCID: PMC3714252.
    33. Li Y, He L, Zeng N, Sahu D, Cadenas E, Shearn C, Li W, Stiles BL. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa). J Biol Chem. 2013 Aug 30; 288(35):25007-24. PMID: 23836899; PMCID: PMC3757167.
    34. Yin F, Jiang T, Cadenas E. Metabolic triad in brain aging: mitochondria, insulin/IGF-1 signalling and JNK signalling. Biochem Soc Trans. 2013 Feb 01; 41(1):101-5. PMID: 23356266.
      View in: PubMed
    35. Li C, Li Y, He L, Agarwal AR, Zeng N, Cadenas E, Stiles BL. PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40. PMID: 23376468; PMCID: PMC3654039.
    36. Marinho HS, Cyrne L, Cadenas E, Antunes F. H2O2 delivery to cells: steady-state versus bolus addition. Methods Enzymol. 2013; 526:159-73. PMID: 23791100.
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    37. Marinho HS, Cyrne L, Cadenas E, Antunes F. The cellular steady-state of H2O2: latency concepts and gradients. Methods Enzymol. 2013; 527:3-19. PMID: 23830623.
      View in: PubMed
    38. Cadenas E, Packer L. Methods in Enzymology. Hydrogen peroxide and cell signaling, part C. Preface. Methods Enzymol. 2013; 528:xv. PMID: 23849873.
      View in: PubMed
    39. Cadenas E, Packer L. Methods in Enzymology. Hydrogen peroxide and cell signaling, part B. Preface. Methods Enzymol. 2013; 527:xv. PMID: 23830638.
      View in: PubMed
    40. Cadenas E, Packer L. Preface. Hydrogen peroxide and cell signaling, part A. Methods Enzymol. 2013; 526:xv. PMID: 23791105.
      View in: PubMed
    41. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. PMID: 23086958; PMCID: PMC3516762.
    42. Agarwal AR, Zhao L, Sancheti H, Sundar IK, Rahman I, Cadenas E. Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 15; 303(10):L889-98. PMID: 23064950.
      View in: PubMed
    43. Yin F, Boveris A, Cadenas E. Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration. Antioxid Redox Signal. 2014 Jan 10; 20(2):353-71. PMID: 22793257; PMCID: PMC3887431.
    44. Yin F, Sancheti H, Cadenas E. Mitochondrial thiols in the regulation of cell death pathways. Antioxid Redox Signal. 2012 Dec 15; 17(12):1714-27. PMID: 22530585; PMCID: PMC3474184.
    45. Ermak G, Sojitra S, Yin F, Cadenas E, Cuervo AM, Davies KJ. Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem. 2012 Apr 20; 287(17):14088-98. PMID: 22389495; PMCID: PMC3340208.
    46. Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One. 2012; 7(2):e31267. PMID: 22393359; PMCID: PMC3290616.
    47. Yin F, Sancheti H, Cadenas E. Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells. Biochim Biophys Acta. 2012 Mar; 1817(3):401-9. PMID: 22198343; PMCID: PMC3269566.
    48. Yao J, Rettberg JR, Klosinski LP, Cadenas E, Brinton RD. Shift in brain metabolism in late onset Alzheimer's disease: implications for biomarkers and therapeutic interventions. Mol Aspects Med. 2011 Aug; 32(4-6):247-57. PMID: 22024249; PMCID: PMC3658304.
    49. Yao J, Chen S, Mao Z, Cadenas E, Brinton RD. 2-Deoxy-D-glucose treatment induces ketogenesis, sustains mitochondrial function, and reduces pathology in female mouse model of Alzheimer's disease. PLoS One. 2011; 6(7):e21788. PMID: 21747957; PMCID: PMC3128612.
    50. Santos RM, Lourenço CF, Gerhardt GA, Cadenas E, Laranjinha J, Barbosa RM. Evidence for a pathway that facilitates nitric oxide diffusion in the brain. Neurochem Int. 2011 Aug; 59(1):90-6. PMID: 21672575.
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    51. Yao J, Irwin R, Chen S, Hamilton R, Cadenas E, Brinton RD. Ovarian hormone loss induces bioenergetic deficits and mitochondrial ß-amyloid. Neurobiol Aging. 2012 Aug; 33(8):1507-21. PMID: 21514693; PMCID: PMC3181273.
    52. Iñarrea P, Casanova A, Alava MA, Iturralde M, Cadenas E. Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free Radic Biol Med. 2011 Jun 01; 50(11):1575-81. PMID: 21397009; PMCID: PMC3144380.
    53. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr. 2011 Jan; 48(1):26-32. PMID: 21297908; PMCID: PMC3022059.
    54. Irwin RW, Yao J, Ahmed SS, Hamilton RT, Cadenas E, Brinton RD. Medroxyprogesterone acetate antagonizes estrogen up-regulation of brain mitochondrial function. Endocrinology. 2011 Feb; 152(2):556-67. PMID: 21159850; PMCID: PMC3157324.
    55. Yao J, Chen S, Cadenas E, Brinton RD. Estrogen protection against mitochondrial toxin-induced cell death in hippocampal neurons: antagonism by progesterone. Brain Res. 2011 Mar 16; 1379:2-10. PMID: 21134358; PMCID: PMC3200366.
    56. Galli F, Cadenas E. Protein post-translational modifications in cell signalling and disease. Free Radic Res. 2011 Jan; 45(1):1-2. PMID: 21047170.
      View in: PubMed
    57. Garcia J, Han D, Sancheti H, Yap LP, Kaplowitz N, Cadenas E. Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54. PMID: 20937819; PMCID: PMC3000945.
    58. Yao J, Hamilton RT, Cadenas E, Brinton RD. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochim Biophys Acta. 2010 Oct; 1800(10):1121-6. PMID: 20538040; PMCID: PMC3200365.
    59. Yap LP, Garcia JV, Han DS, Cadenas E. Role of nitric oxide-mediated glutathionylation in neuronal function: potential regulation of energy utilization. Biochem J. 2010 Apr 28; 428(1):85-93. PMID: 20210787; PMCID: PMC3042800.
    60. Lourenço CF, Santos R, Barbosa RM, Gerhardt G, Cadenas E, Laranjinha J. In vivo modulation of nitric oxide concentration dynamics upon glutamatergic neuronal activation in the hippocampus. Hippocampus. 2011 Jun; 21(6):622-30. PMID: 20169537.
      View in: PubMed
    61. Ledo A, Barbosa R, Cadenas E, Laranjinha J. Dynamic and interacting profiles of *NO and O2 in rat hippocampal slices. Free Radic Biol Med. 2010 Apr 15; 48(8):1044-50. PMID: 20100565; PMCID: PMC2839026.
    62. Yap LP, Sancheti H, Ybanez MD, Garcia J, Cadenas E, Han D. Determination of GSH, GSSG, and GSNO using HPLC with electrochemical detection. Methods Enzymol. 2010; 473:137-47. PMID: 20513475; PMCID: PMC3040068.
    63. Antico Arciuch VG, Galli S, Franco MC, Lam PY, Cadenas E, Carreras MC, Poderoso JJ. Akt1 intramitochondrial cycling is a crucial step in the redox modulation of cell cycle progression. PLoS One. 2009 Oct 21; 4(10):e7523. PMID: 19844585; PMCID: PMC2761088.
    64. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and therapeutics, Part II. Preface. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1233. PMID: 19835920.
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    65. Yap LP, Garcia JV, Han D, Cadenas E. The energy-redox axis in aging and age-related neurodegeneration. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1283-98. PMID: 19716388; PMCID: PMC2784280.
    66. Lam PY, Yin F, Hamilton RT, Boveris A, Cadenas E. Elevated neuronal nitric oxide synthase expression during ageing and mitochondrial energy production. Free Radic Res. 2009 May; 43(5):431-9. PMID: 19347761; PMCID: PMC3319075.
    67. Zhou Q, Lam PY, Han D, Cadenas E. Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett. 2009 Apr 02; 583(7):1132-40. PMID: 19272379; PMCID: PMC2672565.
    68. Golden EB, Lam PY, Kardosh A, Gaffney KJ, Cadenas E, Louie SG, Petasis NA, Chen TC, Schönthal AH. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood. 2009 Jun 04; 113(23):5927-37. PMID: 19190249.
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    69. Lam PY, Cadenas E. Compromised proteasome degradation elevates neuronal nitric oxide synthase levels and induces apoptotic cell death. Arch Biochem Biophys. 2008 Oct 15; 478(2):181-6. PMID: 18706882; PMCID: PMC2614914.
    70. Hamm-Alvarez S, Cadenas E. Mitochondrial medicine and mitochondrion-based therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1437-8. PMID: 18692102.
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    71. Galli S, Antico Arciuch VG, Poderoso C, Converso DP, Zhou Q, Bal de Kier Joffé E, Cadenas E, Boczkowski J, Carreras MC, Poderoso JJ. Tumor cell phenotype is sustained by selective MAPK oxidation in mitochondria. PLoS One. 2008 Jun 11; 3(6):e2379. PMID: 18545666; PMCID: PMC2398776.
    72. Viteri C, Codina M, Cobaleda S, Lahuerta J, Barriga J, Barrera S, Morales MD. [Validation of the Spanish version of the QOLIE-10 quality of life in epilepsy questionnaire]. Neurologia. 2008 Apr; 23(3):157-67. PMID: 18370335.
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    73. Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nilsen J. Progesterone and estrogen regulate oxidative metabolism in brain mitochondria. Endocrinology. 2008 Jun; 149(6):3167-75. PMID: 18292191; PMCID: PMC2408802.
    74. Navarro A, López-Cepero JM, Bández MJ, Sánchez-Pino MJ, Gómez C, Cadenas E, Boveris A. Hippocampal mitochondrial dysfunction in rat aging. Am J Physiol Regul Integr Comp Physiol. 2008 Feb; 294(2):R501-9. PMID: 18077512.
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    75. Zhou Q, Lam PY, Han D, Cadenas E. c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem. 2008 Jan; 104(2):325-35. PMID: 17949412.
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    76. Vauzour D, Vafeiadou K, Rice-Evans C, Cadenas E, Spencer JP. Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway. Arch Biochem Biophys. 2007 Dec 15; 468(2):159-66. PMID: 17976513.
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    77. Antunes F, Boveris A, Cadenas E. On the biologic role of the reaction of NO with oxidized cytochrome c oxidase. Antioxid Redox Signal. 2007 Oct; 9(10):1569-79. PMID: 17665969.
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    78. Packer L, Cadenas E. Oxidants and antioxidants revisited. New concepts of oxidative stress. Free Radic Res. 2007 Sep; 41(9):951-2. PMID: 17729110.
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    79. Iñarrea P, Moini H, Han D, Rettori D, Aguiló I, Alava MA, Iturralde M, Cadenas E. Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis. Biochem J. 2007 Jul 01; 405(1):173-9. PMID: 17394422; PMCID: PMC1925252.
    80. Packer L, Cadenas E, Davies KJ. Free radicals and exercise: an introduction. Free Radic Biol Med. 2008 Jan 15; 44(2):123-5. PMID: 18191747.
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    81. Schroeter H, Bahia P, Spencer JP, Sheppard O, Rattray M, Cadenas E, Rice-Evans C, Williams RJ. (-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons. J Neurochem. 2007 Jun; 101(6):1596-606. PMID: 17298385.
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    82. Antunes F, Cadenas E. The mechanism of cytochrome C oxidase inhibition by nitric oxide. Front Biosci. 2007 Jan 01; 12:975-85. PMID: 17127353.
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    83. Navarro A, Sánchez-Pino MJ, Gómez C, Bández MJ, Cadenas E, Boveris A. Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice. Antioxid Redox Signal. 2007 Jan; 9(1):131-41. PMID: 17115892.
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    84. Hsiai TK, Hwang J, Barr ML, Correa A, Hamilton R, Alavi M, Rouhanizadeh M, Cadenas E, Hazen SL. Hemodynamics influences vascular peroxynitrite formation: Implication for low-density lipoprotein apo-B-100 nitration. Free Radic Biol Med. 2007 Feb 15; 42(4):519-29. PMID: 17275684; PMCID: PMC2561143.
    85. Nguyen DT, Hernandez-Montes E, Vauzour D, Schönthal AH, Rice-Evans C, Cadenas E, Spencer JP. The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway. Free Radic Biol Med. 2006 Oct 15; 41(8):1225-39. PMID: 17015169.
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    86. Ledo A, Barbosa RM, Gerhardt GA, Cadenas E, Laranjinha J. Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17483-8. PMID: 16293699; PMCID: PMC1297656.
    87. Han D, Canali R, Garcia J, Aguilera R, Gallaher TK, Cadenas E. Sites and mechanisms of aconitase inactivation by peroxynitrite: modulation by citrate and glutathione. Biochemistry. 2005 Sep 13; 44(36):11986-96. PMID: 16142896.
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    88. Ghafourifar P, Cadenas E. Mitochondrial nitric oxide synthase. Trends Pharmacol Sci. 2005 Apr; 26(4):190-5. PMID: 15808343.
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    89. Iñarrea P, Moini H, Rettori D, Han D, Martínez J, García I, Fernández-Vizarra E, Iturralde M, Cadenas E. Redox activation of mitochondrial intermembrane space Cu,Zn-superoxide dismutase. Biochem J. 2005 Apr 01; 387(Pt 1):203-9. PMID: 15537389; PMCID: PMC1134948.
    90. Antunes F, Nunes C, Laranjinha J, Cadenas E. Redox interactions of nitric oxide with dopamine and its derivatives. Toxicology. 2005 Mar 15; 208(2):207-12. PMID: 15691585.
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    91. Siems W, Grune T, Sommerburg O, Flohé L, Cadenas E. HNE and Further Lipid Peroxidation Products. Biofactors. 2005; 24(1-4):1-4. PMID: 16403958.
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    92. Remião F, Rettori D, Han D, Carvalho F, Bastos ML, Cadenas E. Leucoisoprenochrome-o-semiquinone formation in freshly isolated adult rat cardiomyocytes. Chem Res Toxicol. 2004 Dec; 17(12):1584-90. PMID: 15606133.
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    93. Antunes F, Boveris A, Cadenas E. On the mechanism and biology of cytochrome oxidase inhibition by nitric oxide. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16774-9. PMID: 15546991; PMCID: PMC534717.
    94. Bustamante J, Di Libero E, Fernandez-Cobo M, Monti N, Cadenas E, Boveris A. Kinetic analysis of thapsigargin-induced thymocyte apoptosis. Free Radic Biol Med. 2004 Nov 01; 37(9):1490-8. PMID: 15454289.
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    95. Cadenas E. Mitochondrial free radical production and cell signaling. Mol Aspects Med. 2004 Feb-Apr; 25(1-2):17-26. PMID: 15051313.
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    96. Schroeter H, Boyd CS, Ahmed R, Spencer JP, Duncan RF, Rice-Evans C, Cadenas E. c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis. Biochem J. 2003 Jun 01; 372(Pt 2):359-69. PMID: 12614194; PMCID: PMC1223409.
    97. Han D, Antunes F, Canali R, Rettori D, Cadenas E. Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem. 2003 Feb 21; 278(8):5557-63. PMID: 12482755.
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    98. Antunes F, Han D, Rettori D, Cadenas E. Mitochondrial damage by nitric oxide is potentiated by dopamine in PC12 cells. Biochim Biophys Acta. 2002 Dec 02; 1556(2-3):233-8. PMID: 12460681.
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    99. Antunes F, Han D, Cadenas E. Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions. Free Radic Biol Med. 2002 Nov 01; 33(9):1260-7. PMID: 12398934.
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    100. Rettori D, Tang Y, Dias LC, Cadenas E. Pathways of dopamine oxidation mediated by nitric oxide. Free Radic Biol Med. 2002 Sep 01; 33(5):685-90. PMID: 12208355.
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    101. Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E. Reverse micelles in organic solvents: a medium for the biotechnological use of extreme halophilic enzymes at low salt concentration. Archaea. 2002 Sep; 1(2):105-11. PMID: 15803648; PMCID: PMC2685557.
    102. Schroeter H, Boyd C, Spencer JP, Williams RJ, Cadenas E, Rice-Evans C. MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide. Neurobiol Aging. 2002 Sep-Oct; 23(5):861-80. PMID: 12392791.
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    103. Riobo NA, Melani M, Sanjuan N, Fiszman ML, Gravielle MC, Carreras MC, Cadenas E, Poderoso JJ. The modulation of mitochondrial nitric-oxide synthase activity in rat brain development. J Biol Chem. 2002 Nov 08; 277(45):42447-55. PMID: 12202479.
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    104. Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E. Mechanism of adaptation of an atypical alkaline p-nitrophenyl phosphatase from the archaeon Halobacterium salinarum at low-water environments. Biotechnol Bioeng. 2002 Jun 05; 78(5):497-502. PMID: 12115118.
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    105. Piera-Velázquez S, Marhuenda-Egea F, Cadenas E. Increased stability of malate dehydrogenase from Halobacterium salinarum at low salt concentration in reverse micelles. Extremophiles. 2002 Oct; 6(5):407-12. PMID: 12382117.
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    106. Laranjinha J, Cadenas E. Oxidation of DOPAC by nitric oxide: effect of superoxide dismutase. J Neurochem. 2002 May; 81(4):892-900. PMID: 12065648.
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    107. Boyd CS, Cadenas E. Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis. Biol Chem. 2002 Mar-Apr; 383(3-4):411-23. PMID: 12033432.
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    108. Marhuenda-Egea FC, Piera-Velázquez S, Cadenas C, Cadenas E. An extreme halophilic enzyme active at low salt in reversed micelles. J Biotechnol. 2002 Feb 14; 93(2):159-64. PMID: 11738722.
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    109. Riobó NA, Schöpfer FJ, Boveris AD, Cadenas E, Poderoso JJ. The reaction of nitric oxide with 6-hydroxydopamine: implications for Parkinson's disease. Free Radic Biol Med. 2002 Jan 15; 32(2):115-21. PMID: 11796199.
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    110. Han D, Antunes F, Daneri F, Cadenas E. Mitochondrial superoxide anion production and release into intermembrane space. Methods Enzymol. 2002; 349:271-80. PMID: 11912916.
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    111. Shahrzad S, Cadenas E, Sevanian A, Packer L. Impact of water-dispersible beadlets as a vehicle for the delivery of carotenoids to cultured cells. Biofactors. 2002; 16(3-4):83-91. PMID: 14530596.
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