Rayudu Gopalakrishna, PhD

TitleAssociate Professor of Integrative Anatomical Sciences
InstitutionUniversity of Southern California
DepartmentIntegrative Anatomical Sciences
AddressBMT 306 A 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1770
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    Collapse Biography 
    Collapse Education and Training
    Andhra University, Visakhapatnam, IndiaB.S.09/1973Biology
    Andhra University, Visakhapatnam, IndiaM.S.09/1975Biochemistry
    University of Madras, Chennai, IndiaPh.D.08/1979Biochemistry
    University of Madras, Chennai, IndiaPost-doc12/1981Biochemistry
    National Cancer Institute, NIH, Bethesda, MDPost-doc11/1983Pathophysiology
    Collapse Awards and Honors
    National Cancer Institute, NIH1988  - 1993FIRST Award
    Keck School of Medicine of USC1995Excellence in Teaching Certificate
    Keck School of Medicine of USC1996Outstanding Teaching Award (year II med))
    Keck School of Medicine of USC2000Outstanding Teaching Award (year II med)
    Keck School of Medicine of USC2003Outstanding Teaching Award (year I med)
    Keck School of Medicine of USC2004Outstanding teaching Award (year II med)
    Keck School of Medicine of USC2006Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2008Outstanding Teaching Award (Year II med)
    Keck School of Medicine of USC2008Master Teacher
    Alpha Omega Alpha2010Membership
    Keck School of Medicine of USC2011Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year II med)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Prostate cancer prevention by selenium supplementation
    NIH/NCI R01CA099216Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    NIH/NCI R01CA062146Dec 15, 1993 - Nov 30, 1998
    Role: Principal Investigator
    NIH/NCI R29CA047142May 1, 1988 - May 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Maniar KH, Jones IA, Gopalakrishna R, Vangsness CT. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 Feb; 19(2):93-102. PMID: 29212381.
      View in: PubMed
    2. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Davis A, McNeill T, Mack W. Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. PMID: 29108990.
      View in: PubMed
    3. Fan TK, Gundimeda U, Mack WJ, Gopalakrishna R. Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. PMID: 27212904; PMCID: PMC4870900.
    4. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. PMID: 25314656.
      View in: PubMed
    5. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. PMID: 24508265.
      View in: PubMed
    6. Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. PMID: 23849860.
      View in: PubMed
    7. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. PMID: 22879598; PMCID: PMC3464573.
    8. Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. PMID: 20936703; PMCID: PMC2965808.
    9. Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61. PMID: 19578042.
      View in: PubMed
    10. Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31. PMID: 18922790; PMCID: PMC3259896.
    11. Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. PMID: 18375950; PMCID: PMC2386917.
    12. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. PMID: 15837589.
      View in: PubMed
    13. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. PMID: 12614334.
      View in: PubMed
    14. Gopalakrishna R, Gundimeda U. Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S. PMID: 12468631.
      View in: PubMed
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