-
Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol- and glycosaminoglycan-binding sites in the laminin receptor. Neural Regen Res. 2025 Mar 01; 20(3):819-820.
Gopalakrishna R, Aguilar J, Lee E, Mack WJ. PMID: 38886954.
View in:
PubMed Mentions:
-
Resveratrol and its metabolites elicit neuroprotection via high-affinity binding to the laminin receptor at low nanomolar concentrations. FEBS Lett. 2024 May; 598(9):995-1007.
Gopalakrishna R, Aguilar J, Oh A, Lee E, Hou L, Lee T, Xu E, Nguyen J, Mack WJ. PMID: 38413095; PMCID: PMC11087200.
View in:
PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
-
Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer's disease prevention. Neural Regen Res. 2023 Dec; 18(12):2675-2676.
Gopalakrishna R, Oh A, Bhat NR, Mack WJ. PMID: 37449618; PMCID: PMC10358646.
View in:
PubMed Mentions:
2
-
Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation. Biochem Biophys Res Commun. 2023 09 03; 671:116-123.
Gopalakrishna R, Oh A, Hou L, Lee E, Aguilar J, Li A, Mack WJ. PMID: 37300941; PMCID: PMC10527810.
View in:
PubMed Mentions:
2 Fields:
-
cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-β uptake and amyloid-β-induced neuronal cell death. FEBS Lett. 2022 11; 596(22):2914-2927.
Gopalakrishna R, Lin CY, Oh A, Le C, Yang S, Hicks A, Kindy MS, Mack WJ, Bhat NR. PMID: 35971617; PMCID: PMC9712173.
View in:
PubMed Mentions:
2 Fields:
-
Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke. Neural Regen Res. 2022 Jan; 17(1):91-92.
Gopalakrishna R, Lin C, Kindy MS, Mack WJ. PMID: 34100435; PMCID: PMC8451563.
View in:
PubMed Mentions:
-
Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Biophys Res Commun. 2020 03 12; 523(3):678-684.
Gopalakrishna R, Mades A, Oh A, Zhu A, Nguyen J, Lin C, Kindy MS, Mack WJ. PMID: 31948754.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases. Neural Regen Res. 2019 Sep; 14(9):1513-1514.
Gopalakrishna R, Bhat NR, Zhou S, Mack WJ. PMID: 31089044; PMCID: PMC6557114.
View in:
PubMed Mentions:
1
-
Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. Free Radic Biol Med. 2018 11 01; 127:55-61.
Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Holmgren A. PMID: 29775743.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimalsCells
-
Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 02; 19(2):93-102.
Maniar KH, Jones IA, Gopalakrishna R, Vangsness CT. PMID: 29212381.
View in:
PubMed Mentions:
24 Fields:
Translation:
Humans
-
Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237.
Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Davis A, McNeill T, Mack W. PMID: 29108990.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansCells
-
Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium. React Oxyg Species (Apex). 2016; 2(4):272-289.
Gopalakrishna R, Gundimeda U, Zhou S, Zung K, Forell K, Holmgren A. PMID: 29795790; PMCID: PMC5961735.
View in:
PubMed Mentions:
8
-
Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6.
Fan TK, Gundimeda U, Mack WJ, Gopalakrishna R. PMID: 27212904; PMCID: PMC4870900.
View in:
PubMed Mentions:
2
-
Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84.
Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. PMID: 25314656.
View in:
PubMed Mentions:
16 Fields:
Translation:
AnimalsCells
-
Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24.
Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. PMID: 24508265.
View in:
PubMed Mentions:
33 Fields:
Translation:
AnimalsCells
-
Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98.
Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. PMID: 23849860.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
-
Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Cε. J Biol Chem. 2012 Oct 05; 287(41):34694-708.
Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. PMID: 22879598; PMCID: PMC3464573.
View in:
PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
-
Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55.
Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. PMID: 20936703; PMCID: PMC2965808.
View in:
PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
-
Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61.
Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. PMID: 19578042.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansCells
-
Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31.
Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. PMID: 18922790; PMCID: PMC3259896.
View in:
PubMed Mentions:
19 Fields:
Translation:
HumansCells
-
A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44.
Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. PMID: 18375950; PMCID: PMC2386917.
View in:
PubMed Mentions:
18 Fields:
Translation:
AnimalsCells
-
The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9.
Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 15837589.
View in:
PubMed Mentions:
6 Fields:
Translation:
AnimalsCells
-
Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8.
Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 12614334.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S.
Gopalakrishna R, Gundimeda U. PMID: 12468631.
View in:
PubMed Mentions:
27 Fields:
Translation:
HumansAnimals
-
Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63.
Gopalakrishna R, Gundimeda U. PMID: 11799924.
View in:
PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
-
Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61.
Gopalakrishna R, Jaken S. PMID: 10924854.
View in:
PubMed Mentions:
177 Fields:
Translation:
HumansAnimalsCells
-
Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58.
Gopalakrishna R, Gundimeda U, Anderson WB, Colburn NH, Slaga TJ. PMID: 10068446.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51.
Gopalakrishna R, Gundimeda U, Fontana JA, Clarke R. PMID: 10355743.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
-
Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86.
Kaul N, Gopalakrishna R, Gundimeda U, Choi J, Forman HJ. PMID: 9466823.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 01; 348(1):37-48.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 9390172.
View in:
PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
-
Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 01; 348(1):25-36.
Gopalakrishna R, Gundimeda U, Chen ZH. PMID: 9390171.
View in:
PubMed Mentions:
15 Fields:
Translation:
AnimalsCells
-
Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72.
Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton DR, Ryan SJ. PMID: 9330847.
View in:
PubMed Mentions: Fields:
Translation:
AnimalsCells
-
Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34.
Hamilton HB, Hinton DR, Law RE, Gopalakrishna R, Su YZ, Chen ZH, Weiss MH, Couldwell WT. PMID: 8755764.
View in:
PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
-
Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 07; 271(23):13504-14.
Gundimeda U, Chen ZH, Gopalakrishna R. PMID: 8662863.
View in:
PubMed Mentions:
43 Fields:
Translation:
HumansAnimalsCells
-
Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6.
Zhang W, Anker L, Law RE, Hinton DR, Gopalakrishna R, Pu Q, Gundimeda U, Weiss MH, Couldwell WT. PMID: 9816239.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606.
Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. PMID: 8595959.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6.
Couldwell WT, Law RE, Hinton DR, Gopalakrishna R, Yong VW, Weiss MH. PMID: 8738488.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansCells
-
Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107.
Sweetman LL, Zhang NY, Peterson H, Gopalakrishna R, Sevanian A. PMID: 7487079.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 7476346.
View in:
PubMed Mentions:
14 Fields:
Translation:
Cells
-
Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12233-7.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 7991611; PMCID: PMC45411.
View in:
PubMed Mentions:
22 Fields:
Translation:
AnimalsCells
-
Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701.
Sheu SJ, Sakamoto T, Osusky R, Wang HM, Ogden TE, Ryan SJ, Hinton DR, Gopalakrishna R. PMID: 7531168.
View in:
PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
-
Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10.
Couldwell WT, Gopalakrishna R, Hinton DR, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. PMID: 7808614.
View in:
PubMed Mentions:
6 Fields:
Translation:
HumansCells
-
Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 8262958.
View in:
PubMed Mentions:
34 Fields:
Translation:
AnimalsCells
-
Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9.
Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH. PMID: 8396364.
View in:
PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
-
Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30.
Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R. PMID: 8424690.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 1472068.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
-
Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54.
Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 1281116.
View in:
PubMed Mentions:
20 Fields:
Translation:
Cells
-
Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35.
Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB. PMID: 1456438.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
-
Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7.
Gopalakrishna R, Anderson WB. PMID: 1654774.
View in:
PubMed Mentions:
12 Fields:
Translation:
Cells