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Rayudu Gopalakrishna, PhD

Title(s)Associate Professor of Integrative Anatomical Sciences
AddressBMT 306 A 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 1770
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    Collapse Biography 
    Collapse Education and Training
    Andhra University, Visakhapatnam, IndiaB.S.09/1973Biology
    Andhra University, Visakhapatnam, IndiaM.S.09/1975Biochemistry
    University of Madras, Chennai, IndiaPh.D.08/1979Biochemistry
    University of Madras, Chennai, IndiaPost-doc12/1981Biochemistry
    National Cancer Institute, NIH, Bethesda, MDPost-doc11/1983Pathophysiology
    Collapse Awards and Honors
    National Cancer Institute, NIH1988  - 1993FIRST Award
    Keck School of Medicine of USC1995Excellence in Teaching Certificate
    Keck School of Medicine of USC1996Outstanding Teaching Award (year II med))
    Keck School of Medicine of USC2000Outstanding Teaching Award (year II med)
    Keck School of Medicine of USC2003Outstanding Teaching Award (year I med)
    Keck School of Medicine of USC2004Outstanding teaching Award (year II med)
    Keck School of Medicine of USC2006Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2008Outstanding Teaching Award (Year II med)
    Keck School of Medicine of USC2008Master Teacher
    Alpha Omega Alpha2010Membership
    Keck School of Medicine of USC2011Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year II med)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Translational potential of the internalization of Nogo-A receptor to enhance axonal regeneration after stroke
    NIH/NINDS R21NS116720Jul 1, 2020 - Jun 30, 2022
    Role: Principal Investigator
    Prostate cancer prevention by selenium supplementation
    NIH/NCI R01CA099216Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    CANCER PREVENTION &IMBALANCE IN PROTEIN PHOSPHORYLATION
    NIH/NCI R01CA062146Dec 15, 1993 - Nov 30, 1998
    Role: Principal Investigator
    TUMOR PROMOTERS AND PROTEIN KINASE C IN CANCER METASTASI
    NIH/NCI R29CA047142May 1, 1988 - May 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Biophys Res Commun. 2020 03 12; 523(3):678-684. Gopalakrishna R, Mades A, Oh A, Zhu A, Nguyen J, Lin C, Kindy MS, Mack WJ. PMID: 31948754.
      View in: PubMed   Mentions:    Fields:    
    2. Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases. Neural Regen Res. 2019 Sep; 14(9):1513-1514. Gopalakrishna R, Bhat NR, Zhou S, Mack WJ. PMID: 31089044.
      View in: PubMed   Mentions:
    3. Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. Free Radic Biol Med. 2018 11 01; 127:55-61. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Holmgren A. PMID: 29775743.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 02; 19(2):93-102. Maniar KH, Jones IA, Gopalakrishna R, Vangsness CT. PMID: 29212381.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Davis A, McNeill T, Mack W. PMID: 29108990.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium. React Oxyg Species (Apex). 2016; 2(4):272-289. Gopalakrishna R, Gundimeda U, Zhou S, Zung K, Forell K, Holmgren A. PMID: 29795790.
      View in: PubMed   Mentions:
    7. Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. Fan TK, Gundimeda U, Mack WJ, Gopalakrishna R. PMID: 27212904.
      View in: PubMed   Mentions:
    8. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. PMID: 25314656.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    9. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. PMID: 24508265.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    10. Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. PMID: 23849860.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    11. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. PMID: 22879598.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    12. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. PMID: 20936703.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    13. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61. Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. PMID: 19578042.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31. Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. PMID: 18922790.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    15. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. PMID: 18375950.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    16. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 15837589.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    17. Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 12614334.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    18. Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S. Gopalakrishna R, Gundimeda U. PMID: 12468631.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    19. Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63. Gopalakrishna R, Gundimeda U. PMID: 11799924.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    20. Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61. Gopalakrishna R, Jaken S. PMID: 10924854.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    21. Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58. Gopalakrishna R, Gundimeda U, Anderson WB, Colburn NH, Slaga TJ. PMID: 10068446.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    22. Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51. Gopalakrishna R, Gundimeda U, Fontana JA, Clarke R. PMID: 10355743.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86. Kaul N, Gopalakrishna R, Gundimeda U, Choi J, Forman HJ. PMID: 9466823.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 01; 348(1):25-36. Gopalakrishna R, Gundimeda U, Chen ZH. PMID: 9390171.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    25. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 01; 348(1):37-48. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 9390172.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    26. Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72. Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton DR, Ryan SJ. PMID: 9330847.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    27. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34. Hamilton HB, Hinton DR, Law RE, Gopalakrishna R, Su YZ, Chen ZH, Weiss MH, Couldwell WT. PMID: 8755764.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    28. Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 07; 271(23):13504-14. Gundimeda U, Chen ZH, Gopalakrishna R. PMID: 8662863.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    29. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6. Zhang W, Anker L, Law RE, Hinton DR, Gopalakrishna R, Pu Q, Gundimeda U, Weiss MH, Couldwell WT. PMID: 9816239.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    30. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. PMID: 8595959.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    31. Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6. Couldwell WT, Law RE, Hinton DR, Gopalakrishna R, Yong VW, Weiss MH. PMID: 8738488.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    32. Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107. Sweetman LL, Zhang NY, Peterson H, Gopalakrishna R, Sevanian A. PMID: 7487079.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    33. Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 7476346.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    34. Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12233-7. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 7991611.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    35. Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701. Sheu SJ, Sakamoto T, Osusky R, Wang HM, Ogden TE, Ryan SJ, Hinton DR, Gopalakrishna R. PMID: 7531168.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    36. Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10. Couldwell WT, Gopalakrishna R, Hinton DR, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. PMID: 7808614.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    37. Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 8262958.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    38. Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9. Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH. PMID: 8396364.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    39. Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30. Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R. PMID: 8424690.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    40. Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 1472068.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    41. Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54. Gopalakrishna R, Chen ZH, Gundimeda U. PMID: 1281116.
      View in: PubMed   Mentions: 18     Fields:    Translation:Cells
    42. Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35. Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB. PMID: 1456438.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    43. Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7. Gopalakrishna R, Anderson WB. PMID: 1654774.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
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