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Rayudu Gopalakrishna, PhD

Title(s)Associate Professor of Integrative Anatomical Sciences
Phone+1 323 442 1770
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    Collapse Biography 
    Collapse Education and Training
    Andhra University, Visakhapatnam, IndiaB.S.09/1973Biology
    Andhra University, Visakhapatnam, IndiaM.S.09/1975Biochemistry
    University of Madras, Chennai, IndiaPh.D.08/1979Biochemistry
    University of Madras, Chennai, IndiaPost-doc12/1981Biochemistry
    National Cancer Institute, NIH, Bethesda, MDPost-doc11/1983Pathophysiology
    Collapse Awards and Honors
    National Cancer Institute, NIH1988  - 1993FIRST Award
    Keck School of Medicine of USC1995Excellence in Teaching Certificate
    Keck School of Medicine of USC1996Outstanding Teaching Award (year II med))
    Keck School of Medicine of USC2000Outstanding Teaching Award (year II med)
    Keck School of Medicine of USC2003Outstanding Teaching Award (year I med)
    Keck School of Medicine of USC2004Outstanding teaching Award (year II med)
    Keck School of Medicine of USC2006Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2008Outstanding Teaching Award (Year II med)
    Keck School of Medicine of USC2008Master Teacher
    Alpha Omega Alpha2010Membership
    Keck School of Medicine of USC2011Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year I med)
    Keck School of Medicine of USC2014Outstanding Teaching Award (Year II med)

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Prostate cancer prevention by selenium supplementation
    NIH/NCI R01CA099216Jul 1, 2009 - May 31, 2014
    Role: Principal Investigator
    CANCER PREVENTION &IMBALANCE IN PROTEIN PHOSPHORYLATION
    NIH/NCI R01CA062146Dec 15, 1993 - Nov 30, 1998
    Role: Principal Investigator
    TUMOR PROMOTERS AND PROTEIN KINASE C IN CANCER METASTASI
    NIH/NCI R29CA047142May 1, 1988 - May 31, 1994
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gopalakrishna R, Bhat NR, Zhou S, Mack WJ. Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases. Neural Regen Res. 2019 Sep; 14(9):1513-1514. PMID: 31089044.
      View in: PubMed
    2. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Holmgren A. Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. Free Radic Biol Med. 2018 11 01; 127:55-61. PMID: 29775743.
      View in: PubMed
    3. Maniar KH, Jones IA, Gopalakrishna R, Vangsness CT. Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 02; 19(2):93-102. PMID: 29212381.
      View in: PubMed
    4. Gopalakrishna R, Gundimeda U, Zhou S, Bui H, Davis A, McNeill T, Mack W. Laminin-1 induces endocytosis of 67KDa laminin receptor and protects Neuroscreen-1 cells against death induced by serum withdrawal. Biochem Biophys Res Commun. 2018 01 01; 495(1):230-237. PMID: 29108990.
      View in: PubMed
    5. Gopalakrishna R, Gundimeda U, Zhou S, Zung K, Forell K, Holmgren A. Imbalance in Protein Thiol Redox Regulation and Cancer-Preventive Efficacy of Selenium. React Oxyg Species (Apex). 2016; 2(4):272-289. PMID: 29795790.
      View in: PubMed
    6. Fan TK, Gundimeda U, Mack WJ, Gopalakrishna R. Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products. Neural Regen Res. 2016 Apr; 11(4):545-6. PMID: 27212904.
      View in: PubMed
    7. Gundimeda U, McNeill TH, Barseghian BA, Tzeng WS, Rayudu DV, Cadenas E, Gopalakrishna R. Polyphenols from green tea prevent antineuritogenic action of Nogo-A via 67-kDa laminin receptor and hydrogen peroxide. J Neurochem. 2015 Jan; 132(1):70-84. PMID: 25314656.
      View in: PubMed
    8. Gundimeda U, McNeill TH, Fan TK, Deng R, Rayudu D, Chen Z, Cadenas E, Gopalakrishna R. Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: role of 67-kDa laminin receptor and hydrogen peroxide. Biochem Biophys Res Commun. 2014 Feb 28; 445(1):218-24. PMID: 24508265.
      View in: PubMed
    9. Gopalakrishna R, McNeill TH, Elhiani AA, Gundimeda U. Methods for studying oxidative regulation of protein kinase C. Methods Enzymol. 2013; 528:79-98. PMID: 23849860.
      View in: PubMed
    10. Gundimeda U, McNeill TH, Elhiani AA, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols precondition against cell death induced by oxygen-glucose deprivation via stimulation of laminin receptor, generation of reactive oxygen species, and activation of protein kinase Ce. J Biol Chem. 2012 Oct 05; 287(41):34694-708. PMID: 22879598.
      View in: PubMed
    11. Gundimeda U, McNeill TH, Schiffman JE, Hinton DR, Gopalakrishna R. Green tea polyphenols potentiate the action of nerve growth factor to induce neuritogenesis: possible role of reactive oxygen species. J Neurosci Res. 2010 Dec; 88(16):3644-55. PMID: 20936703.
      View in: PubMed
    12. Gundimeda U, Schiffman JE, Gottlieb SN, Roth BI, Gopalakrishna R. Negation of the cancer-preventive actions of selenium by over-expression of protein kinase Cepsilon and selenoprotein thioredoxin reductase. Carcinogenesis. 2009 Sep; 30(9):1553-61. PMID: 19578042.
      View in: PubMed
    13. Gundimeda U, Schiffman JE, Chhabra D, Wong J, Wu A, Gopalakrishna R. Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31. PMID: 18922790.
      View in: PubMed
    14. Gopalakrishna R, Gundimeda U, Schiffman JE, McNeill TH. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44. PMID: 18375950.
      View in: PubMed
    15. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. PMID: 15837589.
      View in: PubMed
    16. Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. PMID: 12614334.
      View in: PubMed
    17. Gopalakrishna R, Gundimeda U. Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S. PMID: 12468631.
      View in: PubMed
    18. Gopalakrishna R, Gundimeda U. Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63. PMID: 11799924.
      View in: PubMed
    19. Gopalakrishna R, Jaken S. Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61. PMID: 10924854.
      View in: PubMed
    20. Gopalakrishna R, Gundimeda U, Anderson WB, Colburn NH, Slaga TJ. Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58. PMID: 10068446.
      View in: PubMed
    21. Gopalakrishna R, Gundimeda U, Fontana JA, Clarke R. Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51. PMID: 10355743.
      View in: PubMed
    22. Kaul N, Gopalakrishna R, Gundimeda U, Choi J, Forman HJ. Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86. PMID: 9466823.
      View in: PubMed
    23. Gopalakrishna R, Chen ZH, Gundimeda U. Selenocompounds induce a redox modulation of protein kinase C in the cell, compartmentally independent from cytosolic glutathione: its role in inhibition of tumor promotion. Arch Biochem Biophys. 1997 Dec 01; 348(1):37-48. PMID: 9390172.
      View in: PubMed
    24. Gopalakrishna R, Gundimeda U, Chen ZH. Cancer-preventive selenocompounds induce a specific redox modification of cysteine-rich regions in Ca(2+)-dependent isoenzymes of protein kinase C. Arch Biochem Biophys. 1997 Dec 01; 348(1):25-36. PMID: 9390171.
      View in: PubMed
    25. Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton DR, Ryan SJ. Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Curr Eye Res. 1997 Oct; 16(10):967-72. PMID: 9330847.
      View in: PubMed
    26. Hamilton HB, Hinton DR, Law RE, Gopalakrishna R, Su YZ, Chen ZH, Weiss MH, Couldwell WT. Inhibition of cellular growth and induction of apoptosis in pituitary adenoma cell lines by the protein kinase C inhibitor hypericin: potential therapeutic application. J Neurosurg. 1996 Aug; 85(2):329-34. PMID: 8755764.
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    27. Gundimeda U, Chen ZH, Gopalakrishna R. Tamoxifen modulates protein kinase C via oxidative stress in estrogen receptor-negative breast cancer cells. J Biol Chem. 1996 Jun 07; 271(23):13504-14. PMID: 8662863.
      View in: PubMed
    28. Zhang W, Anker L, Law RE, Hinton DR, Gopalakrishna R, Pu Q, Gundimeda U, Weiss MH, Couldwell WT. Enhancement of radiosensitivity in human malignant glioma cells by hypericin in vitro. Clin Cancer Res. 1996 May; 2(5):843-6. PMID: 9816239.
      View in: PubMed
    29. Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1996 Mar; 37(4):597-606. PMID: 8595959.
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    30. Couldwell WT, Law RE, Hinton DR, Gopalakrishna R, Yong VW, Weiss MH. Protein kinase C and growth regulation of pituitary adenomas. Acta Neurochir Suppl. 1996; 65:22-6. PMID: 8738488.
      View in: PubMed
    31. Sweetman LL, Zhang NY, Peterson H, Gopalakrishna R, Sevanian A. Effect of linoleic acid hydroperoxide on endothelial cell calcium homeostasis and phospholipid hydrolysis. Arch Biochem Biophys. 1995 Oct 20; 323(1):97-107. PMID: 7487079.
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    32. Gopalakrishna R, Chen ZH, Gundimeda U. Modifications of cysteine-rich regions in protein kinase C induced by oxidant tumor promoters and enzyme-specific inhibitors. Methods Enzymol. 1995; 252:132-46. PMID: 7476346.
      View in: PubMed
    33. Gopalakrishna R, Chen ZH, Gundimeda U. Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):12233-7. PMID: 7991611.
      View in: PubMed
    34. Sheu SJ, Sakamoto T, Osusky R, Wang HM, Ogden TE, Ryan SJ, Hinton DR, Gopalakrishna R. Transforming growth factor-beta regulates human retinal pigment epithelial cell phagocytosis by influencing a protein kinase C-dependent pathway. Graefes Arch Clin Exp Ophthalmol. 1994 Nov; 232(11):695-701. PMID: 7531168.
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    35. Couldwell WT, Gopalakrishna R, Hinton DR, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. Hypericin: a potential antiglioma therapy. Neurosurgery. 1994 Oct; 35(4):705-9; discussion 709-10. PMID: 7808614.
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    36. Gopalakrishna R, Chen ZH, Gundimeda U. Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem. 1993 Dec 25; 268(36):27180-5. PMID: 8262958.
      View in: PubMed
    37. Gopalakrishna R, Gundimeda U, Wilson JC, Chen ZH. Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem. 1993 Jul; 212(1):296-9. PMID: 8396364.
      View in: PubMed
    38. Gundimeda U, Hara SK, Anderson WB, Gopalakrishna R. Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys. 1993 Jan; 300(1):526-30. PMID: 8424690.
      View in: PubMed
    39. Gopalakrishna R, Chen ZH, Gundimeda U. Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):950-7. PMID: 1472068.
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    40. Gopalakrishna R, Chen ZH, Gundimeda U. Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett. 1992 Dec 14; 314(2):149-54. PMID: 1281116.
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    41. Gopalakrishna R, Chen ZH, Gundimeda U, Wilson JC, Anderson WB. Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem. 1992 Oct; 206(1):24-35. PMID: 1456438.
      View in: PubMed
    42. Gopalakrishna R, Anderson WB. Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys. 1991 Mar; 285(2):382-7. PMID: 1654774.
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