Christian Pike, PhD
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Title(s) | Professor |
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Address | 3715 McClintock Ave., Suite 306D University Park Campus Los Angeles CA 90089-0191
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Phone | +1 213 740 4205 |
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vCard | Download vCard |
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Biography Alzheimer's Association | 2000 | | Turken Award |
Overview Research in my lab is broadly focused on Alzheimer’s disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational approaches that will be useful in the prevention and/or treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, wild-type and transgenic rodent models, and cultured cells.
A primary area of focus in my laboratory is the relationship between age-related loss of steroid hormones and the development of AD. For example, our research with postmortem human brain has helped to identify testosterone loss in aging men as a risk factor for AD. In rodent models, we observe that depletion of androgens accelerates development of AD-like neuropathology and increases neuronal vulnerability to toxic insult. Cell culture studies continue to identify the relevant underlying mechanisms for these androgen effects, including investigation of classic genomic actions (e.g., regulation of genes such as neprilysin) as well as activation of rapid cell signaling pathways (e.g., MAPK/ERK, CREB, PKC). In ongoing translational studies, we are building upon our basic science advances to develop specific therapeutic interventions that selectively activate protective androgen pathways (e.g., synthetic testosterone mimetics). Using this general research strategy, we are pursuing conceptually parallel basic science and translational projects to evaluate the interactions between estrogen and progesterone actions in the regulation of neurodegenerative cascades associated with AD.
A new area of research in the lab seeks to understand the relationships between obesity, type 2 diabetes, and AD. Recent epidemiological findings have identified obesity in middle age, and its downstream consequences metabolic syndrome and type 2 diabetes, as significant risk factors for the development of AD in old age. Our efforts are focused at understanding the mechanistic links between these conditions, including the interactive roles of adiposity, neuroinflammation, and age-related changes in testosterone and estrogen.
Research ORNG Applications Bibliographic
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Second to fourth digit ratio (2D:4D) is associated with dementia in women. Early Hum Dev. 2020 Oct; 149:105152.
Jiang J, Young K, Pike CJ. PMID: 32781308.
View in: PubMed Mentions: Fields:
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Dementia risk in women higher in same-sex than opposite-sex twins. Alzheimers Dement (Amst). 2020; 12(1):e12049.
Luo J, Beam CR, Karlsson IK, Pike CJ, Reynolds CA, Gatz M. PMID: 32582836.
View in: PubMed Mentions:
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Aging Reduces Estradiol Protection Against Neural but Not Metabolic Effects of Obesity in Female 3xTg-AD Mice. Front Aging Neurosci. 2020; 12:113.
Christensen A, Liu J, Pike CJ. PMID: 32431604.
View in: PubMed Mentions:
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Staining and Quantification of ß-Amyloid Pathology in Transgenic Mouse Models of Alzheimer's Disease. Methods Mol Biol. 2020; 2144:211-221.
Christensen A, Pike CJ. PMID: 32410038.
View in: PubMed Mentions: Fields:
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APOE genotype affects metabolic and Alzheimer-related outcomes induced by Western diet in female EFAD mice. FASEB J. 2019 03; 33(3):4054-4066.
Christensen A, Pike CJ. PMID: 30509127.
View in: PubMed Mentions: 3 Fields: Translation: Animals
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TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity. J Neuroinflammation. 2018 Nov 05; 15(1):306.
Moser VA, Uchoa MF, Pike CJ. PMID: 30396359.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Effects of aging, high-fat diet, and testosterone treatment on neural and metabolic outcomes in male brown Norway rats. Neurobiol Aging. 2019 01; 73:145-160.
Moser VA, Christensen A, Liu J, Zhou A, Yagi S, Beam CR, Galea L, Pike CJ. PMID: 30359877.
View in: PubMed Mentions: 1 Fields: Translation: Animals
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Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212.
Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
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TSPO ligand PK11195 improves Alzheimer-related outcomes in aged female 3xTg-AD mice. Neurosci Lett. 2018 09 14; 683:7-12.
Christensen A, Pike CJ. PMID: 29925037.
View in: PubMed Mentions: 4 Fields: Translation: Animals
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The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550.
Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905.
View in: PubMed Mentions: 7 Fields: Translation: Humans
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Obesity Accelerates Alzheimer-Related Pathology in APOE4 but not APOE3 Mice. eNeuro. 2017 May-Jun; 4(3).
Moser VA, Pike CJ. PMID: 28612048.
View in: PubMed Mentions: 19 Fields: Translation: HumansAnimals
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Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice. PLoS One. 2017; 12(6):e0178490.
Christensen A, Pike CJ. PMID: 28575011.
View in: PubMed Mentions: 8 Fields: Translation: Animals
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Sex and the development of Alzheimer's disease. J Neurosci Res. 2017 01 02; 95(1-2):671-680.
Pike CJ. PMID: 27870425.
View in: PubMed Mentions: 65 Fields: Translation: HumansAnimals
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Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors. Front Neuroendocrinol. 2016 10; 43:60-82.
Uchoa MF, Moser VA, Pike CJ. PMID: 27651175.
View in: PubMed Mentions: 20 Fields: Translation: HumansAnimals
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Obesity and sex interact in the regulation of Alzheimer's disease. Neurosci Biobehav Rev. 2016 Aug; 67:102-18.
Moser VA, Pike CJ. PMID: 26708713.
View in: PubMed Mentions: 14 Fields: Translation: Humans
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The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging. 2016 Jan; 37:47-57.
Cacciottolo M, Christensen A, Moser A, Liu J, Pike CJ, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC, , Finch CE. PMID: 26686669.
View in: PubMed Mentions: 25 Fields: Translation: HumansAnimals
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Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci. 2015; 7:130.
Christensen A, Pike CJ. PMID: 26217222.
View in: PubMed Mentions:
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The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiol Aging. 2015 Jul; 36(7):2282-2295.
Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike CJ, Mack WJ, Cadenas E, Brinton RD. PMID: 25921624.
View in: PubMed Mentions: 34 Fields: Translation: AnimalsCells
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Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. Endocrinology. 2015 Mar; 156(3):1091-9.
Barron AM, Brown MA, Morgan TE, Pike CJ. PMID: 25514084.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
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Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. J Neuroinflammation. 2014 Sep 16; 11:162.
Jayaraman A, Lent-Schochet D, Pike CJ. PMID: 25224590.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions. Curr Diab Rep. 2014 Apr; 14(4):476.
Jayaraman A, Pike CJ. PMID: 24526623.
View in: PubMed Mentions: 42 Fields: Translation: HumansAnimals
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Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014 Apr; 155(4):1398-406.
Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike CJ. PMID: 24428527.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons. Mol Cell Endocrinol. 2014 Mar 25; 384(1-2):52-60.
Jayaraman A, Pike CJ. PMID: 24424444.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
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Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PLoS One. 2013; 8(10):e78554.
Barron AM, Rosario ER, Elteriefi R, Pike CJ. PMID: 24205258.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013 May 15; 33(20):8891-7.
Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike CJ. PMID: 23678130.
View in: PubMed Mentions: 42 Fields: Translation: HumansAnimals
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Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging. 2013 Apr; 34(4):1080-9.
Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike CJ, Garcia-Segura LM, Melcangi RC. PMID: 23122920.
View in: PubMed Mentions: 23 Fields: Translation: Animals
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17ß-estradiol and progesterone regulate expression of ß-amyloid clearance factors in primary neuron cultures and female rat brain. Endocrinology. 2012 Nov; 153(11):5467-79.
Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike CJ. PMID: 22962256.
View in: PubMed Mentions: 20 Fields: Translation: AnimalsCells
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Evaluation of the effects of testosterone and luteinizing hormone on regulation of ß-amyloid in male 3xTg-AD mice. Brain Res. 2012 Jul 23; 1466:137-45.
Rosario ER, Carroll JC, Pike CJ. PMID: 22587890.
View in: PubMed Mentions: 9 Fields: Translation: Animals
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Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav. 2013 Feb; 63(2):301-7.
Vest RS, Pike CJ. PMID: 22554955.
View in: PubMed Mentions: 53 Fields: Translation: HumansAnimals
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Caspase activation contributes to astrogliosis. Brain Res. 2012 Apr 23; 1450:102-15.
Aras R, Barron AM, Pike CJ. PMID: 22436850.
View in: PubMed Mentions: 11 Fields: Translation: AnimalsCells
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Continuous versus cyclic progesterone exposure differentially regulates hippocampal gene expression and functional profiles. PLoS One. 2012; 7(2):e31267.
Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike CJ, Mack WJ, Brinton RD. PMID: 22393359.
View in: PubMed Mentions: 22 Fields: Translation: AnimalsCells
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Sex hormones, aging, and Alzheimer's disease. Front Biosci (Elite Ed). 2012 Jan 01; 4:976-97.
Barron AM, Pike CJ. PMID: 22201929.
View in: PubMed Mentions: 53 Fields: Translation: Humans
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Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-ß. J Neurochem. 2010 Dec; 115(5):1277-87.
Aguirre C, Jayaraman A, Pike C, Baudry M. PMID: 20977477.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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Sex differences in ß-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res. 2010 Dec 17; 1366:233-45.
Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, Pike CJ. PMID: 20934413.
View in: PubMed Mentions: 66 Fields: Translation: HumansAnimals
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Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010 Nov 04; 1359:281-90.
Rosario ER, Carroll J, Pike CJ. PMID: 20807511.
View in: PubMed Mentions: 36 Fields: Translation: AnimalsCells
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Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 2010 Jun; 151(6):2713-22.
Carroll JC, Rosario ER, Villamagna A, Pike CJ. PMID: 20410196.
View in: PubMed Mentions: 40 Fields: Translation: AnimalsCells
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Age-related changes in serum and brain levels of androgens in male Brown Norway rats. Neuroreport. 2009 Nov 25; 20(17):1534-7.
Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike CJ. PMID: 19829160.
View in: PubMed Mentions: 14 Fields: Translation: AnimalsCells
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Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons. Brain Res. 2009 Nov 17; 1298:1-12.
Nguyen TV, Yao M, Pike CJ. PMID: 19729001.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
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Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging. 2011 Apr; 32(4):604-13.
Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike CJ. PMID: 19428144.
View in: PubMed Mentions: 76 Fields: Translation: Humans
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Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol. 2009 Jul; 30(2):239-58.
Pike CJ, Carroll JC, Rosario ER, Barron AM. PMID: 19427328.
View in: PubMed Mentions: 136 Fields: Translation: HumansAnimals
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Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats. Neurosci Lett. 2008 Nov 21; 445(3):229-32.
Carroll JC, Rosario ER, Pike CJ. PMID: 18790007.
View in: PubMed Mentions: 19 Fields: Translation: AnimalsCells
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Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem. 2008 Jun 01; 105(6):2477-88.
Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike CJ. PMID: 18346198.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimalsCells
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Progesterone receptors: form and function in brain. Front Neuroendocrinol. 2008 May; 29(2):313-39.
Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike CJ, Mack WJ, Stanczyk FZ, Nilsen J. PMID: 18374402.
View in: PubMed Mentions: 156 Fields: Translation: HumansAnimalsCells
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Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology. 2008 May; 149(5):2607-11.
Carroll JC, Pike CJ. PMID: 18276750.
View in: PubMed Mentions: 35 Fields: Translation: Animals
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Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007 Nov 28; 27(48):13357-65.
Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike CJ. PMID: 18045930.
View in: PubMed Mentions: 128 Fields: Translation: Animals
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Androgen cell signaling pathways involved in neuroprotective actions. Horm Behav. 2008 May; 53(5):693-705.
Pike CJ, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER. PMID: 18222446.
View in: PubMed Mentions: 53 Fields: Translation: HumansCells
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Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Res Rev. 2008 Mar; 57(2):444-53.
Rosario ER, Pike CJ. PMID: 17658612.
View in: PubMed Mentions: 27 Fields: Translation: HumansAnimals
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Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology. 2007 Jun; 148(6):2936-43.
Nguyen TV, Yao M, Pike CJ. PMID: 17347309.
View in: PubMed Mentions: 26 Fields: Translation: AnimalsCells
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Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. J Neurosci. 2007 Feb 07; 27(6):1422-33.
Yao M, Nguyen TV, Pike CJ. PMID: 17287517.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
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Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci. 2006 Dec 20; 26(51):13384-9.
Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike CJ. PMID: 17182789.
View in: PubMed Mentions: 54 Fields: Translation: Animals
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Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Res. 2006 Jul 12; 1099(1):206-10.
Rosario ER, Ramsden M, Pike CJ. PMID: 16793026.
View in: PubMed Mentions: 32 Fields: Translation: Animals
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Androgens, aging, and Alzheimer's disease. Endocrine. 2006 Apr; 29(2):233-41.
Pike CJ, Rosario ER, Nguyen TV. PMID: 16785599.
View in: PubMed Mentions: 26 Fields: Translation: HumansAnimalsCells
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Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. J Neurochem. 2006 Jan; 96(1):204-17.
Cordey M, Pike CJ. PMID: 16336227.
View in: PubMed Mentions: 10 Fields: Translation: AnimalsCells
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Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. J Neurochem. 2005 Sep; 94(6):1639-51.
Nguyen TV, Yao M, Pike CJ. PMID: 16011741.
View in: PubMed Mentions: 69 Fields: Translation: AnimalsCells
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The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9.
Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 15837589.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
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Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Res. 2005 May 31; 1045(1-2):217-23.
Cordey M, Pike CJ. PMID: 15910780.
View in: PubMed Mentions: 21 Fields: Translation: AnimalsCells
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Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci. 2005 Feb 02; 25(5):1149-58.
Yao M, Nguyen TV, Pike CJ. PMID: 15689551.
View in: PubMed Mentions: 46 Fields: Translation: HumansAnimalsCells
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Age-related testosterone depletion and the development of Alzheimer disease. JAMA. 2004 Sep 22; 292(12):1431-2.
Rosario ER, Chang L, Stanczyk FZ, Pike CJ. PMID: 15383512.
View in: PubMed Mentions: 58 Fields: Translation: Humans
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Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 2003 May 09; 971(2):239-44.
Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike CJ. PMID: 12706240.
View in: PubMed Mentions: 15 Fields: Translation: AnimalsCells
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Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8.
Cordey M, Gundimeda U, Gopalakrishna R, Pike CJ. PMID: 12614334.
View in: PubMed Mentions: 27 Fields: Translation: AnimalsCells
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The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94.
Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. PMID: 12025818.
View in: PubMed Mentions: 3 Fields: Translation: HumansCells
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Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. Brain Res. 2001 Nov 16; 919(1):160-5.
Pike CJ. PMID: 11689174.
View in: PubMed Mentions: 64 Fields: Translation: AnimalsCells
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Year | Publications |
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2001 | 1 | 2002 | 1 | 2003 | 2 | 2004 | 1 | 2005 | 5 | 2006 | 3 | 2007 | 5 | 2008 | 4 | 2009 | 4 | 2010 | 4 | 2012 | 7 | 2013 | 2 | 2014 | 5 | 2015 | 4 | 2016 | 1 | 2017 | 4 | 2018 | 5 | 2020 | 4 |
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