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    Christian Pike, PhD

    TitleProfessor
    SchoolSchool of Gerontology
    DepartmentGerontology
    AddressGER 306C
    University Park Campus
    Los Angeles California 90089-0191
    Phone+1 213 740 4205
    Emailcjpike@usc.edu
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      Research in my lab is broadly focused on Alzheimer’s disease (AD), with the general goals of elucidating factors that regulate AD pathogenesis and pursuing translational approaches that will be useful in the prevention and/or treatment of the disease. Our approach to investigating research questions involves the use of complementary cellular, biochemical and molecular techniques to analyze relationships in human tissues, wild-type and transgenic rodent models, and cultured cells.

      A primary area of focus in my laboratory is the relationship between age-related loss of steroid hormones and the development of AD. For example, our research with postmortem human brain has helped to identify testosterone loss in aging men as a risk factor for AD. In rodent models, we observe that depletion of androgens accelerates development of AD-like neuropathology and increases neuronal vulnerability to toxic insult. Cell culture studies continue to identify the relevant underlying mechanisms for these androgen effects, including investigation of classic genomic actions (e.g., regulation of genes such as neprilysin) as well as activation of rapid cell signaling pathways (e.g., MAPK/ERK, CREB, PKC). In ongoing translational studies, we are building upon our basic science advances to develop specific therapeutic interventions that selectively activate protective androgen pathways (e.g., synthetic testosterone mimetics). Using this general research strategy, we are pursuing conceptually parallel basic science and translational projects to evaluate the interactions between estrogen and progesterone actions in the regulation of neurodegenerative cascades associated with AD.

      A new area of research in the lab seeks to understand the relationships between obesity, type 2 diabetes, and AD. Recent epidemiological findings have identified obesity in middle age, and its downstream consequences metabolic syndrome and type 2 diabetes, as significant risk factors for the development of AD in old age. Our efforts are focused at understanding the mechanistic links between these conditions, including the interactive roles of adiposity, neuroinflammation, and age-related changes in testosterone and estrogen.


      Collapse Biography 
      Collapse Awards and Honors
      Alzheimer's Association2000Turken Award

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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Pike C. Sex and the development of Alzheimer's disease. J Neurosci Res. 2017 Jan 2; 95(1-2):671-680. PMID: 27870425.
        View in: PubMed
      2. Uchoa MF, Moser VA, Pike C. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors. Front Neuroendocrinol. 2016 Sep 17. PMID: 27651175.
        View in: PubMed
      3. Moser VA, Pike C. Obesity and sex interact in the regulation of Alzheimer's disease. Neurosci Biobehav Rev. 2016 Aug; 67:102-18. PMID: 26708713.
        View in: PubMed
      4. Cacciottolo M, Christensen A, Moser A, Liu J, Pike C, Smith C, LaDu MJ, Sullivan PM, Morgan TE, Dolzhenko E, Charidimou A, Wahlund LO, Wiberg MK, Shams S, Chiang GC. The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer's disease of humans and mice. Neurobiol Aging. 2016 Jan; 37:47-57. PMID: 26686669.
        View in: PubMed
      5. Christensen A, Pike C. Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease. Front Aging Neurosci. 2015; 7:130. PMID: 26217222.
        View in: PubMed
      6. Yin F, Yao J, Sancheti H, Feng T, Melcangi RC, Morgan TE, Finch CE, Pike C, Mack WJ, Cadenas E, Brinton RD. The perimenopausal aging transition in the female rat brain: decline in bioenergetic systems and synaptic plasticity. Neurobiol Aging. 2015 Jul; 36(7):2282-95. PMID: 25921624.
        View in: PubMed
      7. Barron AM, Brown MA, Morgan TE, Pike C. Impact of continuous versus discontinuous progesterone on estradiol regulation of neuron viability and sprouting after entorhinal cortex lesion in female rats. Endocrinology. 2015 Mar; 156(3):1091-9. PMID: 25514084.
        View in: PubMed
      8. Jayaraman A, Lent-Schochet D, Pike C. Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function. J Neuroinflammation. 2014; 11(1):162. PMID: 25224590.
        View in: PubMed
      9. Jayaraman A, Pike C. Alzheimer's disease and type 2 diabetes: multiple mechanisms contribute to interactions. Curr Diab Rep. 2014 Apr; 14(4):476. PMID: 24526623.
        View in: PubMed
      10. Jayaraman A, Christensen A, Moser VA, Vest RS, Miller CP, Hattersley G, Pike C. Selective Androgen Receptor Modulator RAD140 Is Neuroprotective in Cultured Neurons and Kainate-Lesioned Male Rats. Endocrinology. 2014 Apr; 155(4):1398-406. PMID: 24428527.
        View in: PubMed
      11. Jayaraman A, Pike C. Differential effects of synthetic progestagens on neuron survival and estrogen neuroprotection in cultured neurons. Mol Cell Endocrinol. 2014 Mar 25; 384(1-2):52-60. PMID: 24424444.
        View in: PubMed
      12. Barron AM, Rosario ER, Elteriefi R, Pike C. Sex-Specific Effects of High Fat Diet on Indices of Metabolic Syndrome in 3xTg-AD Mice: Implications for Alzheimer's Disease. PLoS One. 2013; 8(10):e78554. PMID: 24205258.
        View in: PubMed
      13. Barron AM, Garcia-Segura LM, Caruso D, Jayaraman A, Lee JW, Melcangi RC, Pike C. Ligand for translocator protein reverses pathology in a mouse model of Alzheimer's disease. J Neurosci. 2013 May 15; 33(20):8891-7. PMID: 23678130.
        View in: PubMed
      14. Caruso D, Barron AM, Brown MA, Abbiati F, Carrero P, Pike C, Garcia-Segura LM, Melcangi RC. Age-related changes in neuroactive steroid levels in 3xTg-AD mice. Neurobiol Aging. 2013 Apr; 34(4):1080-9. PMID: 23122920.
        View in: PubMed
      15. Jayaraman A, Carroll JC, Morgan TE, Lin S, Zhao L, Arimoto JM, Murphy MP, Beckett TL, Finch CE, Brinton RD, Pike C. 17ß-Estradiol and Progesterone Regulate Expression of ß-Amyloid Clearance Factors in Primary Neuron Cultures and Female Rat Brain. Endocrinology. 2012 Nov; 153(11):5467-79. PMID: 22962256.
        View in: PubMed
      16. Rosario ER, Carroll JC, Pike C. Evaluation of the effects of testosterone and luteinizing hormone on regulation of ß-amyloid in male 3xTg-AD mice. Brain Res. 2012 Jul 23; 1466:137-45. PMID: 22587890.
        View in: PubMed
      17. Vest RS, Pike C. Gender, sex steroid hormones, and Alzheimer's disease. Horm Behav. 2013 Feb; 63(2):301-7. PMID: 22554955.
        View in: PubMed
      18. Aras R, Barron AM, Pike C. Caspase activation contributes to astrogliosis. Brain Res. 2012 Apr 23; 1450:102-15. PMID: 22436850.
        View in: PubMed
      19. Zhao L, Morgan TE, Mao Z, Lin S, Cadenas E, Finch CE, Pike C, Mack WJ, Brinton RD. Continuous versus Cyclic Progesterone Exposure Differentially Regulates Hippocampal Gene Expression and Functional Profiles. PLoS One. 2012; 7(2):e31267. PMID: 22393359.
        View in: PubMed
      20. Barron AM, Pike C. Sex hormones, aging, and Alzheimer's disease. Front Biosci (Elite Ed). 2012; 4:976-97. PMID: 22201929.
        View in: PubMed
      21. Aguirre C, Jayaraman A, Pike C, Baudry M. Progesterone inhibits estrogen-mediated neuroprotection against excitotoxicity by down-regulating estrogen receptor-ß. J Neurochem. 2010 Dec; 115(5):1277-87. PMID: 20977477.
        View in: PubMed
      22. Carroll JC, Rosario ER, Kreimer S, Villamagna A, Gentzschein E, Stanczyk FZ, Pike C. Sex differences in ß-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposure. Brain Res. 2010 Dec 17; 1366:233-45. PMID: 20934413.
        View in: PubMed
      23. Rosario ER, Carroll J, Pike C. Testosterone regulation of Alzheimer-like neuropathology in male 3xTg-AD mice involves both estrogen and androgen pathways. Brain Res. 2010 Nov 4; 1359:281-90. PMID: 20807511.
        View in: PubMed
      24. Carroll JC, Rosario ER, Villamagna A, Pike C. Continuous and cyclic progesterone differentially interact with estradiol in the regulation of Alzheimer-like pathology in female 3xTransgenic-Alzheimer's disease mice. Endocrinology. 2010 Jun; 151(6):2713-22. PMID: 20410196.
        View in: PubMed
      25. Rosario ER, Chang L, Beckett TL, Carroll JC, Paul Murphy M, Stanczyk FZ, Pike C. Age-related changes in serum and brain levels of androgens in male Brown Norway rats. Neuroreport. 2009 Nov 25; 20(17):1534-7. PMID: 19829160.
        View in: PubMed
      26. Nguyen TV, Yao M, Pike C. Dihydrotestosterone activates CREB signaling in cultured hippocampal neurons. Brain Res. 2009 Nov 17; 1298:1-12. PMID: 19729001.
        View in: PubMed
      27. Rosario ER, Chang L, Head EH, Stanczyk FZ, Pike C. Brain levels of sex steroid hormones in men and women during normal aging and in Alzheimer's disease. Neurobiol Aging. 2011 Apr; 32(4):604-13. PMID: 19428144.
        View in: PubMed
      28. Pike C, Carroll JC, Rosario ER, Barron AM. Protective actions of sex steroid hormones in Alzheimer's disease. Front Neuroendocrinol. 2009 Jul; 30(2):239-58. PMID: 19427328.
        View in: PubMed
      29. Carroll JC, Rosario ER, Pike C. Progesterone blocks estrogen neuroprotection from kainate in middle-aged female rats. Neurosci Lett. 2008 Nov 21; 445(3):229-32. PMID: 18790007.
        View in: PubMed
      30. Yao M, Nguyen TV, Rosario ER, Ramsden M, Pike C. Androgens regulate neprilysin expression: role in reducing beta-amyloid levels. J Neurochem. 2008 Jun 1; 105(6):2477-88. PMID: 18346198.
        View in: PubMed
      31. Brinton RD, Thompson RF, Foy MR, Baudry M, Wang J, Finch CE, Morgan TE, Pike C, Mack WJ, Stanczyk FZ, Nilsen J. Progesterone receptors: form and function in brain. Front Neuroendocrinol. 2008 May; 29(2):313-39. PMID: 18374402.
        View in: PubMed
      32. Carroll JC, Pike C. Selective estrogen receptor modulators differentially regulate Alzheimer-like changes in female 3xTg-AD mice. Endocrinology. 2008 May; 149(5):2607-11. PMID: 18276750.
        View in: PubMed
      33. Carroll JC, Rosario ER, Chang L, Stanczyk FZ, Oddo S, LaFerla FM, Pike C. Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice. J Neurosci. 2007 Nov 28; 27(48):13357-65. PMID: 18045930.
        View in: PubMed
      34. Pike C, Nguyen TV, Ramsden M, Yao M, Murphy MP, Rosario ER. Androgen cell signaling pathways involved in neuroprotective actions. Horm Behav. 2008 May; 53(5):693-705. PMID: 18222446.
        View in: PubMed
      35. Rosario ER, Pike C. Androgen regulation of beta-amyloid protein and the risk of Alzheimer's disease. Brain Res Rev. 2008 Mar; 57(2):444-53. PMID: 17658612.
        View in: PubMed
      36. Nguyen TV, Yao M, Pike C. Flutamide and cyproterone acetate exert agonist effects: induction of androgen receptor-dependent neuroprotection. Endocrinology. 2007 Jun; 148(6):2936-43. PMID: 17347309.
        View in: PubMed
      37. Yao M, Nguyen TV, Pike C. Estrogen regulates Bcl-w and Bim expression: role in protection against beta-amyloid peptide-induced neuronal death. J Neurosci. 2007 Feb 7; 27(6):1422-33. PMID: 17287517.
        View in: PubMed
      38. Rosario ER, Carroll JC, Oddo S, LaFerla FM, Pike C. Androgens regulate the development of neuropathology in a triple transgenic mouse model of Alzheimer's disease. J Neurosci. 2006 Dec 20; 26(51):13384-9. PMID: 17182789.
        View in: PubMed
      39. Rosario ER, Ramsden M, Pike C. Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Res. 2006 Jul 12; 1099(1):206-10. PMID: 16793026.
        View in: PubMed
      40. Pike C, Rosario ER, Nguyen TV. Androgens, aging, and Alzheimer's disease. Endocrine. 2006 Apr; 29(2):233-41. PMID: 16785599.
        View in: PubMed
      41. Cordey M, Pike C. Conventional protein kinase C isoforms mediate neuroprotection induced by phorbol ester and estrogen. J Neurochem. 2006 Jan; 96(1):204-17. PMID: 16336227.
        View in: PubMed
      42. Nguyen TV, Yao M, Pike C. Androgens activate mitogen-activated protein kinase signaling: role in neuroprotection. J Neurochem. 2005 Sep; 94(6):1639-51. PMID: 16011741.
        View in: PubMed
      43. Cordey M, Gundimeda U, Gopalakrishna R, Pike C. The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9. PMID: 15837589.
        View in: PubMed
      44. Cordey M, Pike C. Neuroprotective properties of selective estrogen receptor agonists in cultured neurons. Brain Res. 2005 May 31; 1045(1-2):217-23. PMID: 15910780.
        View in: PubMed
      45. Yao M, Nguyen TV, Pike C. Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci. 2005 Feb 2; 25(5):1149-58. PMID: 15689551.
        View in: PubMed
      46. Rosario ER, Chang L, Stanczyk FZ, Pike C. Age-related testosterone depletion and the development of Alzheimer disease. JAMA. 2004 Sep 22; 292(12):1431-2. PMID: 15383512.
        View in: PubMed
      47. Ramsden M, Berchtold NC, Patrick Kesslak J, Cotman CW, Pike C. Exercise increases the vulnerability of rat hippocampal neurons to kainate lesion. Brain Res. 2003 May 9; 971(2):239-44. PMID: 12706240.
        View in: PubMed
      48. Cordey M, Gundimeda U, Gopalakrishna R, Pike C. Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8. PMID: 12614334.
        View in: PubMed
      49. Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Med. 2002; 1(1):81-94. PMID: 12025818.
        View in: PubMed
      50. Pike C. Testosterone attenuates beta-amyloid toxicity in cultured hippocampal neurons. Brain Res. 2001 Nov 16; 919(1):160-5. PMID: 11689174.
        View in: PubMed
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