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    David Warburton, MD

    TitleProfessor of Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHLA 4650 W. Sunset Blvd.
    Off Campus
    Los Angeles California 90026
    Phone+1 323 361 5422
    Emaildwarburton@chla.usc.edu
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      Professor David Warburton is a world leader in child health and regenerative medicine. Born and medically educated in London, at Harvard and Brown, he has made a broad translational impact in pediatrics. His major contributions range from clinical studies establishing management practices of extreme prematurity, to infants of diabetics, to basic mechanisms of organ morphogenesis, repair and regeneration. He is thus a seminal figure in neonatal- perinatal medicine, developmental biology, stem cell biology and regenerative medicine. His most highly cited work established and leads the field of molecular embryology of the lung, showing how growth factors and matrix molecules direct formation and repair of the gas exchange surface. Active UK collaborations include Liverpool, Cardiff and London, supported by UK Foreign and Commonwealth Office, MRC, BBSRC and build on his NIH and CIRM funded programs. He mentors UK Doctoral and Postdoctoral Fellows (Basic Science and Clinical), supported by funders ranging from MRC and Wellcome Trust to Royal College of Surgeons of England. An elected Fellow of the Royal Colleges of Surgeons, Physicians as well as Paediatrics and Child Health, he regularly gives keynotes at major US and world scientific meetings as well as teaching in Liverpool, Cardiff, Birmingham and London. In Los Angeles, he hosts UK and other foreign scientific delegations including the Ministers of Science, Heads of Welsh and Scottish Parliaments, Lords Mayor of Manchester and London and HRH Prince Andrew. His personal contribution and enthusiastic support for UK/US Science collaboration has been recognized by several awards including, in 2009, the Order of the British Empire. His commitment to the development of science for human benefit is evident from his many scientific and clinical discoveries, his personal mentoring through to his public advising.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Bower DV, Lansdale N, Navarro S, Truong TV, Bower DJ, Featherstone NC, Connell MG, Al-Alam D, Frey MR, Trinh LA, Fernandez GE, Warburton D, Fraser SE, Bennett D, Jesudason EC. SERCA directs cell migration and branching across species and germ layers. Biol Open. 2017 Aug 17. PMID: 28821490.
        View in: PubMed
      2. Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood JS, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N, LungMAP Consortium T. LungMAP: The Molecular Atlas of Lung Development Program. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 10; ajplung.00139.2017. PMID: 28798251.
        View in: PubMed
      3. Navarro S, Reddy R, Lee J, Warburton D, Driscoll B. Inhaled resveratrol treatments slow ageing-related degenerative changes in mouse lung. Thorax. 2017 May; 72(5):451-459. PMID: 28070015.
        View in: PubMed
      4. Turcatel G, Millette K, Thornton M, Leguizamon S, Grubbs B, Shi W, Warburton D. Cartilage rings contribute to the proper embryonic tracheal epithelial differentiation, metabolism, and expression of inflammatory genes. Am J Physiol Lung Cell Mol Physiol. 2017 Feb 01; 312(2):L196-L207. PMID: 27941074.
        View in: PubMed
      5. Li L, Qi X, Sun W, Abdel-Azim H, Lou S, Zhu H, Prasadarao NV, Zhou A, Shimada H, Shudo K, Kim YM, Khazal S, He Q, Warburton D, Wu L. Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and mortality. EMBO Mol Med. 2016 11; 8(11):1340-1359. PMID: 27737899.
        View in: PubMed
      6. Ren S, Luo Y, Chen H, Warburton D, Lam HC, Wang LL, Chen P, Henske EP, Shi W. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. Am J Pathol. 2016 Dec; 186(12):3261-3272. PMID: 27768862.
        View in: PubMed
      7. Bokka KK, Jesudason EC, Warburton D, Lubkin SR. Quantifying cellular and subcellular stretches in embryonic lung epithelia under peristalsis: where to look for mechanosensing. Interface Focus. 2016 Oct 06; 6(5):20160031. PMID: 27708758.
        View in: PubMed
      8. Jakubzick CV, Warburton D. Can Alveolar Macrophages Made from Stem Cells Achieve Functional Rescue of Lung Diseases? Am J Respir Crit Care Med. 2016 Jun 01; 193(11):1187-8. PMID: 27248582; PMCID: PMC4910901 [Available on 06/01/17].
      9. Brennan SC, Wilkinson WJ, Tseng HE, Finney B, Monk B, Dibble H, Quilliam S, Warburton D, Galietta LJ, Kemp PJ, Riccardi D. The extracellular calcium-sensing receptor regulates human fetal lung development via CFTR. Sci Rep. 2016 Feb 25; 6:21975. PMID: 26911344; PMCID: PMC4766410.
      10. Krainock M, Toubat O, Danopoulos S, Beckham A, Warburton D, Kim R. Epicardial Epithelial-to-Mesenchymal Transition in Heart Development and Disease. J Clin Med. 2016 Feb 19; 5(2). PMID: 26907357; PMCID: PMC4773783.
      11. George UZ, Bokka KK, Warburton D, Lubkin SR. Quantifying stretch and secretion in the embryonic lung: Implications for morphogenesis. Mech Dev. 2015 Nov; 138 Pt 3:356-63. PMID: 26189687; PMCID: PMC4762038.
      12. Bokka KK, Jesudason EC, Warburton D, Lubkin SR. Morphogenetic implications of peristaltic fluid-tissue dynamics in the embryonic lung. J Theor Biol. 2015 Oct 07; 382:378-85. PMID: 26165454; PMCID: PMC4762031 [Available on 10/07/16].
      13. Buckley S, Shi W, Xu W, Frey MR, Moats R, Pardo A, Selman M, Warburton D. Increased alveolar soluble annexin V promotes lung inflammation and fibrosis. Eur Respir J. 2015 Nov; 46(5):1417-29. PMID: 26160872; PMCID: PMC4767328 [Available on 11/01/16].
      14. Bokka KK, Jesudason EC, Lozoya OA, Guilak F, Warburton D, Lubkin SR. Morphogenetic Implications of Peristalsis-Driven Fluid Flow in the Embryonic Lung. PLoS One. 2015; 10(7):e0132015. PMID: 26147967; PMCID: PMC4493131.
      15. Luo Y, El Agha E, Turcatel G, Chen H, Chiu J, Warburton D, Bellusci S, Qian BP, Menke DB, Shi W. Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. BMC Biol. 2015 Jun 20; 13:42. PMID: 26092405; PMCID: PMC4702410.
      16. Li Y, Trivedi V, Truong TV, Koos DS, Lansford R, Chuong CM, Warburton D, Moats RA, Fraser SE. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015 Apr 13; 6:6798. PMID: 25865282; PMCID: PMC4403347.
      17. Luo Y, Xu W, Chen H, Warburton D, Dong R, Qian B, Selman M, Gauldie J, Kolb M, Shi W. A novel profibrotic mechanism mediated by TGFß-stimulated collagen prolyl hydroxylase expression in fibrotic lung mesenchymal cells. J Pathol. 2015 Jul; 236(3):384-94. PMID: 25779936; PMCID: PMC4457642.
      18. Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015 Mar 15; 142(6):1125-36. PMID: 25758223.
        View in: PubMed
      19. Darehzereshki A, Rubin N, Gamba L, Kim J, Fraser J, Huang Y, Billings J, Mohammadzadeh R, Wood J, Warburton D, Kaartinen V, Lien CL. Differential regenerative capacity of neonatal mouse hearts after cryoinjury. Dev Biol. 2015 Mar 01; 399(1):91-9. PMID: 25555840; PMCID: PMC4339535.
      20. Bower DV, Lee HK, Lansford R, Zinn K, Warburton D, Fraser SE, Jesudason EC. Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission. BMC Biol. 2014 Nov 11; 12:92. PMID: 25385196; PMCID: PMC4255442.
      21. Enkhmaa D, Warburton N, Javzandulam B, Uyanga J, Khishigsuren Y, Lodoysamba S, Enkhtur S, Warburton D. Seasonal ambient air pollution correlates strongly with spontaneous abortion in Mongolia. BMC Pregnancy Childbirth. 2014 Apr 23; 14:146. PMID: 24758249; PMCID: PMC4024019.
      22. Varma S, Mahavadi P, Sasikumar S, Cushing L, Hyland T, Rosser AE, Riccardi D, Lu J, Kalin TV, Kalinichenko VV, Guenther A, Ramirez MI, Pardo A, Selman M, Warburton D. Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 01; 306(5):L405-19. PMID: 24375798; PMCID: PMC3949053.
      23. Turcatel G, Rubin N, Menke DB, Martin G, Shi W, Warburton D. Lung mesenchymal expression of Sox9 plays a critical role in tracheal development. BMC Biol. 2013 Nov 25; 11:117. PMID: 24274029; PMCID: PMC4222279.
      24. Guo Y, Chen TH, Zeng X, Warburton D, Boström KI, Ho CM, Zhao X, Garfinkel A. Branching patterns emerge in a mathematical model of the dynamics of lung development. J Physiol. 2014 Jan 15; 592(2):313-24. PMID: 24247979; PMCID: PMC3922496.
      25. Zhang W, Menke DB, Jiang M, Chen H, Warburton D, Turcatel G, Lu CH, Xu W, Luo Y, Shi W. Spatial-temporal targeting of lung-specific mesenchyme by a Tbx4 enhancer. BMC Biol. 2013 Nov 13; 11:111. PMID: 24225400; PMCID: PMC3907025.
      26. Moodley Y, Thompson P, Warburton D. Stem cells: a recapitulation of development. Respirology. 2013 Nov; 18(8):1167-76. PMID: 24033442.
        View in: PubMed
      27. Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, Roche T, Buckley S, Driscoll B, Perin L, Warburton D. Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage. PLoS One. 2013; 8(8):e71679. PMID: 23967234; PMCID: PMC3742516.
      28. Lu K, Reddy R, Berika M, Warburton D, El-Hashash AH. Abrogation of Eya1/Six1 disrupts the saccular phase of lung morphogenesis and causes remodeling. Dev Biol. 2013 Oct 01; 382(1):110-23. PMID: 23895934.
        View in: PubMed
      29. Wang Y, Huang Z, Nayak PS, Matthews BD, Warburton D, Shi W, Sanchez-Esteban J. Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin a6ß1-ADAM17/tumor necrosis factor-a-converting enzyme (TACE) signaling pathway. J Biol Chem. 2013 Aug 30; 288(35):25646-57. PMID: 23888051; PMCID: PMC3757225.
      30. Choi IS, Yu K, Kim J, De Guzman E, Weisenberger DJ, Oghamian S, Kim HJ, Lee KH, Carroll C, Trinh BN, Kim M, Houshdaran S, Laird PW, Jones PA, Warburton D, Liang G, Koh CJ. Alterations in deoxyribonucleic acid (DNA) methylation patterns of Calca, Timp3, Mmp2, and Igf2r are associated with chronic cystitis in a cyclophosphamide-induced mouse model. Urology. 2013 Jul; 82(1):253.e9-15. PMID: 23806407; PMCID: PMC3697025.
      31. Warburton D, Gilliland F, Dashdendev B. Environmental pollution in Mongolia: effects across the lifespan. Environ Res. 2013 Jul; 124:65-6. PMID: 23673312; PMCID: PMC4043223.
      32. Al Alam D, Warburton D. Wingless: developmentally important genes that respond adversely to smoking. Thorax. 2013 Aug; 68(8):703-4. PMID: 23611881; PMCID: PMC3726201.
      33. Warburton D, Shi W, Xu B. TGF-ß-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development? Am J Physiol Lung Cell Mol Physiol. 2013 Jan 15; 304(2):L83-5. PMID: 23161884; PMCID: PMC4073936.
      34. Warburton D, Garcia O. New ideas in lung regeneration: a personal view from Estoril. Expert Rev Respir Med. 2012 Nov; 6(5):507-8. PMID: 23134244.
        View in: PubMed
      35. Varma S, Cao Y, Tagne JB, Lakshminarayanan M, Li J, Friedman TB, Morell RJ, Warburton D, Kotton DN, Ramirez MI. The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem. 2012 Oct 26; 287(44):37282-95. PMID: 22955271; PMCID: PMC3481326.
      36. Lee YS, Wysocki A, Warburton D, Tuan TL. Wound healing in development. Birth Defects Res C Embryo Today. 2012 Sep; 96(3):213-22. PMID: 23109317; PMCID: PMC3678537.
      37. Al Alam D, Sala FG, Baptista S, Galzote R, Danopoulos S, Tiozzo C, Gage P, Grikscheit T, Warburton D, Frey MR, Bellusci S. FGF9-Pitx2-FGF10 signaling controls cecal formation in mice. Dev Biol. 2012 Sep 15; 369(2):340-8. PMID: 22819677; PMCID: PMC3725282.
      38. Xu W, Lan Q, Chen M, Chen H, Zhu N, Zhou X, Wang J, Fan H, Yan CS, Kuang JL, Warburton D, Togbe D, Ryffel B, Zheng SG, Shi W. Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. PLoS One. 2012; 7(7):e40314. PMID: 22792275; PMCID: PMC3392250.
      39. Garcia O, Buckley S, Navarro S, Driscoll B, Warburton D. Modulating the alveolar milieu to enhance resolution of fibrotic lung injury. Proc Am Thorac Soc. 2012 Jul; 9(3):117-9. PMID: 22802284.
        View in: PubMed
      40. Sanchez-Lara PA, Zhao H, Bajpai R, Abdelhamid AI, Warburton D. Impact of stem cells in craniofacial regenerative medicine. Front Physiol. 2012; 3:188. PMID: 22737127; PMCID: PMC3380335.
      41. El-Hashash AH, Warburton D. Numb expression and asymmetric versus symmetric cell division in distal embryonic lung epithelium. J Histochem Cytochem. 2012 Sep; 60(9):675-82. PMID: 22713487; PMCID: PMC3524558.
      42. El-Hashash AH, Turcatel G, Varma S, Berika M, Al Alam D, Warburton D. Eya1 protein phosphatase regulates tight junction formation in lung distal epithelium. J Cell Sci. 2012 Sep 01; 125(Pt 17):4036-48. PMID: 22685326; PMCID: PMC3482315.
      43. Warburton D. Developmental responses to lung injury: repair or fibrosis. Fibrogenesis Tissue Repair. 2012; 5(Suppl 1):S2. PMID: 23259863; PMCID: PMC3368777.
      44. Xu B, Chen H, Xu W, Zhang W, Buckley S, Zheng SG, Warburton D, Kolb M, Gauldie J, Shi W. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2012 Jul; 303(2):L89-96. PMID: 22610349; PMCID: PMC3404628.
      45. Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. PMID: 22302195; PMCID: PMC3312511.
      46. Turcatel G, Rubin N, El-Hashash A, Warburton D. MIR-99a and MIR-99b modulate TGF-ß induced epithelial to mesenchymal plasticity in normal murine mammary gland cells. PLoS One. 2012; 7(1):e31032. PMID: 22299047; PMCID: PMC3267767.
      47. Garcia O, Carraro G, Navarro S, Bertoncello I, McQualter J, Driscoll B, Jesudason E, Warburton D. Cell-based therapies for lung disease. Br Med Bull. 2012; 101:147-61. PMID: 22279079; PMCID: PMC3695661.
      48. Driscoll B, Kikuchi A, Lau AN, Lee J, Reddy R, Jesudason E, Kim CF, Warburton D. Isolation and characterization of distal lung progenitor cells. Methods Mol Biol. 2012; 879:109-22. PMID: 22610556; PMCID: PMC3710291.
      49. Matthews JA, Sala FG, Speer AL, Warburton D, Grikscheit TC. VEGF optimizes the formation of tissue-engineered small intestine. Regen Med. 2011 Sep; 6(5):559-67. PMID: 21916592.
        View in: PubMed
      50. Al Alam D, Green M, Tabatabai Irani R, Parsa S, Danopoulos S, Sala FG, Branch J, El Agha E, Tiozzo C, Voswinckel R, Jesudason EC, Warburton D, Bellusci S. Contrasting expression of canonical Wnt signaling reporters TOPGAL, BATGAL and Axin2(LacZ) during murine lung development and repair. PLoS One. 2011; 6(8):e23139. PMID: 21858009; PMCID: PMC3153464.
      51. Farkas L, Farkas D, Warburton D, Gauldie J, Shi W, Stampfli MR, Voelkel NF, Kolb M. Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L391-401. PMID: 21743024.
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      52. Buckley S, Shi W, Carraro G, Sedrakyan S, Da Sacco S, Driscoll BA, Perin L, De Filippo RE, Warburton D. The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. PMID: 21700959; PMCID: PMC3262671.
      53. Weiss DJ, Bertoncello I, Borok Z, Kim C, Panoskaltsis-Mortari A, Reynolds S, Rojas M, Stripp B, Warburton D, Prockop DJ. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc. 2011 Jun; 8(3):223-72. PMID: 21653527; PMCID: PMC3132784.
      54. Lazarus A, Del-Moral PM, Ilovich O, Mishani E, Warburton D, Keshet E. A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development. 2011 Jun; 138(11):2359-68. PMID: 21558382; PMCID: PMC3091498.
      55. Matthews JA, Sala FG, Speer AL, Li Y, Warburton D, Grikscheit TC. Mesenchymal-specific inhibition of vascular endothelial growth factor (VEGF) attenuates growth in neonatal mice. J Surg Res. 2012 Jan; 172(1):40-7. PMID: 21696760.
        View in: PubMed
      56. Dashdendev B, Fukushima LK, Woo MS, Ganbaatar E, Warburton D. Carbon monoxide pollution and lung function in urban compared with rural Mongolian children. Respirology. 2011 May; 16(4):653-8. PMID: 21362106.
        View in: PubMed
      57. El-Hashash AH, Turcatel G, Al Alam D, Buckley S, Tokumitsu H, Bellusci S, Warburton D. Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development. 2011 Apr; 138(7):1395-407. PMID: 21385765; PMCID: PMC3050666.
      58. Jackson SR, Lee J, Reddy R, Williams GN, Kikuchi A, Freiberg Y, Warburton D, Driscoll B. Partial pneumonectomy of telomerase null mice carrying shortened telomeres initiates cell growth arrest resulting in a limited compensatory growth response. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L898-909. PMID: 21460122; PMCID: PMC3119124.
      59. El-Hashash AH, Al Alam D, Turcatel G, Rogers O, Li X, Bellusci S, Warburton D. Six1 transcription factor is critical for coordination of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 May 15; 353(2):242-58. PMID: 21385574; PMCID: PMC3114882.
      60. El-Hashash AH, Warburton D. Cell polarity and spindle orientation in the distal epithelium of embryonic lung. Dev Dyn. 2011 Feb; 240(2):441-5. PMID: 21246661; PMCID: PMC3023987.
      61. Frey MR, Carraro G, Batra RK, Polk DB, Warburton D. Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty. Cancer Biol Ther. 2011 Jan 01; 11(1):122-4. PMID: 21124074.
        View in: PubMed
      62. Jackson SR, Williams GN, Lee J, Baer JF, Warburton D, Driscoll B. A modified technique for partial pneumonectomy in the mouse. J Invest Surg. 2011; 24(2):81-6. PMID: 21345008.
        View in: PubMed
      63. Sala FG, Del Moral PM, Tiozzo C, Alam DA, Warburton D, Grikscheit T, Veltmaat JM, Bellusci S. FGF10 controls the patterning of the tracheal cartilage rings via Shh. Development. 2011 Jan; 138(2):273-82. PMID: 21148187; PMCID: PMC3005603.
      64. El-Hashash AH, Al Alam D, Turcatel G, Bellusci S, Warburton D. Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung. Dev Biol. 2011 Feb 01; 350(1):112-26. PMID: 21129374; PMCID: PMC3022116.
      65. Farkas L, Farkas D, Gauldie J, Warburton D, Shi W, Kolb M. Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):870-8. PMID: 20705941; PMCID: PMC3135847.
      66. Jesudason EC, Keshet E, Warburton D. Entrained pulmonary clocks: epithelium and vasculature keeping pace. Am J Physiol Lung Cell Mol Physiol. 2010 Oct; 299(4):L453-4. PMID: 20693313.
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      67. Carraro G, del Moral PM, Warburton D. Mouse embryonic lung culture, a system to evaluate the molecular mechanisms of branching. J Vis Exp. 2010 Jun 30; (40). PMID: 20644505; PMCID: PMC3156062.
      68. Batra RK, Warburton D. On the derivation and clinical implications of "driver" mutations in lung cancer. Am J Respir Crit Care Med. 2010 Jul 01; 182(1):4-5. PMID: 20463175.
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      69. Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. PMID: 20195358; PMCID: PMC2827539.
      70. Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol. 2010 Mar; 183(3):1193-200. PMID: 20096867; PMCID: PMC3174101.
      71. Chung S, Kang DO, Yamzon J, Warburton D, Koh CJ. O-GlcNAc mediated glycosylation down-regulation in mice with cyclophosphamide induced cystitis. J Urol. 2010 Jan; 183(1):351-6. PMID: 19914650; PMCID: PMC2840040.
      72. Del Moral PM, Warburton D. Explant culture of mouse embryonic whole lung, isolated epithelium, or mesenchyme under chemically defined conditions as a system to evaluate the molecular mechanism of branching morphogenesis and cellular differentiation. Methods Mol Biol. 2010; 633:71-9. PMID: 20204620; PMCID: PMC3120103.
      73. Warburton D, El-Hashash A, Carraro G, Tiozzo C, Sala F, Rogers O, De Langhe S, Kemp PJ, Riccardi D, Torday J, Bellusci S, Shi W, Lubkin SR, Jesudason E. Lung organogenesis. Curr Top Dev Biol. 2010; 90:73-158. PMID: 20691848; PMCID: PMC3340128.
      74. Maciewicz RA, Warburton D, Rennard SI. Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2009 Dec 01; 6(7):614-7. PMID: 19934358.
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      75. Rennard SI, Warburton D. Introduction: Ninth Lund COPD Symposium. Proc Am Thorac Soc. 2009 Dec 01; 6(7):557. PMID: 19934348.
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      76. Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST. A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med. 2010 Feb 15; 181(4):328-36. PMID: 19926868; PMCID: PMC2822972.
      77. Tiozzo C, De Langhe S, Carraro G, Alam DA, Nagy A, Wigfall C, Hajihosseini MK, Warburton D, Minoo P, Bellusci S. Fibroblast growth factor 10 plays a causative role in the tracheal cartilage defects in a mouse model of Apert syndrome. Pediatr Res. 2009 Oct; 66(4):386-90. PMID: 19581825; PMCID: PMC3725279.
      78. El-Hashash AH, Warburton D, Kimber SJ. Genes and signals regulating murine trophoblast cell development. Mech Dev. 2010 Jan-Feb; 127(1-2):1-20. PMID: 19755154; PMCID: PMC2865247.
      79. Cunnick JM, Schmidhuber S, Chen G, Yu M, Yi SJ, Cho YJ, Kaartinen V, Minoo P, Warburton D, Groffen J, Heisterkamp N. Bcr and Abr cooperate in negatively regulating acute inflammatory responses. Mol Cell Biol. 2009 Nov; 29(21):5742-50. PMID: 19703997; PMCID: PMC2772743.
      80. Shi W, Xu J, Warburton D. Development, repair and fibrosis: what is common and why it matters. Respirology. 2009 Jul; 14(5):656-65. PMID: 19659647; PMCID: PMC2747658.
      81. Carraro G, El-Hashash A, Guidolin D, Tiozzo C, Turcatel G, Young BM, De Langhe SP, Bellusci S, Shi W, Parnigotto PP, Warburton D. miR-17 family of microRNAs controls FGF10-mediated embryonic lung epithelial branching morphogenesis through MAPK14 and STAT3 regulation of E-Cadherin distribution. Dev Biol. 2009 Sep 15; 333(2):238-50. PMID: 19559694; PMCID: PMC2735610.
      82. Gupte VV, Ramasamy SK, Reddy R, Lee J, Weinreb PH, Violette SM, Guenther A, Warburton D, Driscoll B, Minoo P, Bellusci S. Overexpression of fibroblast growth factor-10 during both inflammatory and fibrotic phases attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med. 2009 Sep 01; 180(5):424-36. PMID: 19498056; PMCID: PMC2742760.
      83. Wang Y, Maciejewski BS, Soto-Reyes D, Lee HS, Warburton D, Sanchez-Esteban J. Mechanical stretch promotes fetal type II epithelial cell differentiation via shedding of HB-EGF and TGF-alpha. J Physiol. 2009 Apr 15; 587(Pt 8):1739-53. PMID: 19237431; PMCID: PMC2683961.
      84. Warburton D, Chiu A, Lee KA, Chung HM, Cha KY, Kim KS. The 2nd International Collaborative Symposium on Stem Cell Research. Regen Med. 2009 Jan; 4(1):129-31. PMID: 19105622; PMCID: PMC2865236.
      85. Finney BA, del Moral PM, Wilkinson WJ, Cayzac S, Cole M, Warburton D, Kemp PJ, Riccardi D. Regulation of mouse lung development by the extracellular calcium-sensing receptor, CaR. J Physiol. 2008 Dec 15; 586(24):6007-19. PMID: 18955379; PMCID: PMC2655418.
      86. Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. PMID: 18719226; PMCID: PMC3174105.
      87. Ding W, Warburton D. Down-regulation of Sprouty2 via p38 MAPK plays a key role in the induction of cellular apoptosis by tumor necrosis factor-alpha. Biochem Biophys Res Commun. 2008 Oct 24; 375(3):460-4. PMID: 18713620; PMCID: PMC2575769.
      88. Warburton D, Perin L, Defilippo R, Bellusci S, Shi W, Driscoll B. Stem/progenitor cells in lung development, injury repair, and regeneration. Proc Am Thorac Soc. 2008 Aug 15; 5(6):703-6. PMID: 18684721; PMCID: PMC2645263.
      89. Warburton D. Developmental biology: order in the lung. Nature. 2008 Jun 05; 453(7196):733-5. PMID: 18528385; PMCID: PMC2865228.
      90. Heisterkamp N, Groffen J, Warburton D, Sneddon TP. The human gamma-glutamyltransferase gene family. Hum Genet. 2008 May; 123(4):321-32. PMID: 18357469.
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      91. Shan L, Subramaniam M, Emanuel RL, Degan S, Johnston P, Tefft D, Warburton D, Sunday ME. Centrifugal migration of mesenchymal cells in embryonic lung. Dev Dyn. 2008 Mar; 237(3):750-7. PMID: 18297731; PMCID: PMC3340126.
      92. Sun J, Chen H, Chen C, Whitsett JA, Mishina Y, Bringas P, Ma JC, Warburton D, Shi W. Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol. 2008 Mar; 172(3):571-82. PMID: 18258849; PMCID: PMC2258256.
      93. Unbekandt M, del Moral PM, Sala FG, Bellusci S, Warburton D, Fleury V. Tracheal occlusion increases the rate of epithelial branching of embryonic mouse lung via the FGF10-FGFR2b-Sprouty2 pathway. Mech Dev. 2008 Mar-Apr; 125(3-4):314-24. PMID: 18082381; PMCID: PMC2275719.
      94. Warburton D, Kaartinen V. When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation? J Physiol. 2007 Oct 15; 584(Pt 2):365. PMID: 17932141; PMCID: PMC2277164.
      95. Ask K, Bonniaud P, Maass K, Eickelberg O, Margetts PJ, Warburton D, Groffen J, Gauldie J, Kolb M. Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol. 2008; 40(3):484-95. PMID: 17931953; PMCID: PMC2350199.
      96. Ding W, Shi W, Bellusci S, Groffen J, Heisterkamp N, Minoo P, Warburton D. Sprouty2 downregulation plays a pivotal role in mediating crosstalk between TGF-beta1 signaling and EGF as well as FGF receptor tyrosine kinase-ERK pathways in mesenchymal cells. J Cell Physiol. 2007 Sep; 212(3):796-806. PMID: 17516543.
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      97. Moeller A, Ask K, Warburton D, Gauldie J, Kolb M. The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol. 2008; 40(3):362-82. PMID: 17936056; PMCID: PMC2323681.
      98. Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R. TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 2007 Sep 05; 26(17):3957-67. PMID: 17673906; PMCID: PMC1994119.
      99. Shi W, Bellusci S, Warburton D. Lung development and adult lung diseases. Chest. 2007 Aug; 132(2):651-6. PMID: 17699136.
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      100. Ramasamy SK, Mailleux AA, Gupte VV, Mata F, Sala FG, Veltmaat JM, Del Moral PM, De Langhe S, Parsa S, Kelly LK, Kelly R, Shia W, Keshet E, Minoo P, Warburton D, Bellusci S. Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev Biol. 2007 Jul 15; 307(2):237-47. PMID: 17560563; PMCID: PMC3714306.
      101. Zhu NL, Li C, Huang HH, Sebald M, Londhe VA, Heisterkamp N, Warburton D, Bellusci S, Minoo P. TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells. Gene. 2007 May 15; 393(1-2):70-80. PMID: 17350185; PMCID: PMC1945170.
      102. Warburton D, Koh C, Chung HM, Cha KR, Kim KS. Meeting report: the first international collaborative symposium on stem cell research, Seoul, Korea. Stem Cells. 2007 May; 25(5):1337-8. PMID: 17272495.
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      103. Warburton D, Gauldie J, Bellusci S, Shi W. Lung development and susceptibility to chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Nov; 3(8):668-72. PMID: 17065371.
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      104. Gauldie J, Kolb M, Ask K, Martin G, Bonniaud P, Warburton D. Smad3 signaling involved in pulmonary fibrosis and emphysema. Proc Am Thorac Soc. 2006 Nov; 3(8):696-702. PMID: 17065376; PMCID: PMC2647655.
      105. Li WY, Huang EY, Dudas M, Kaartinen V, Warburton D, Tuan TL. Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction. Wound Repair Regen. 2006 Sep-Oct; 14(5):516-25. PMID: 17014662.
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      106. Sala FG, Curtis JL, Veltmaat JM, Del Moral PM, Le LT, Fairbanks TJ, Warburton D, Ford H, Wang K, Burns RC, Bellusci S. Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev Biol. 2006 Nov 15; 299(2):373-85. PMID: 16956603.
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      107. Sun J, Zhuang FF, Mullersman JE, Chen H, Robertson EJ, Warburton D, Liu YH, Shi W. BMP4 activation and secretion are negatively regulated by an intracellular gremlin-BMP4 interaction. J Biol Chem. 2006 Sep 29; 281(39):29349-56. PMID: 16880207.
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      108. De Langhe SP, Carraro G, Warburton D, Hajihosseini MK, Bellusci S. Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev Biol. 2006 Nov 01; 299(1):52-62. PMID: 16989802.
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      109. del Moral PM, De Langhe SP, Sala FG, Veltmaat JM, Tefft D, Wang K, Warburton D, Bellusci S. Differential role of FGF9 on epithelium and mesenchyme in mouse embryonic lung. Dev Biol. 2006 May 01; 293(1):77-89. PMID: 16494859.
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      110. Fairbanks TJ, Sala FG, Kanard R, Curtis JL, Del Moral PM, De Langhe S, Warburton D, Anderson KD, Bellusci S, Burns RC. The fibroblast growth factor pathway serves a regulatory role in proliferation and apoptosis in the pathogenesis of intestinal atresia. J Pediatr Surg. 2006 Jan; 41(1):132-6; discussion 132-6. PMID: 16410122.
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      111. Del Moral PM, Sala FG, Tefft D, Shi W, Keshet E, Bellusci S, Warburton D. VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev Biol. 2006 Feb 01; 290(1):177-88. PMID: 16375885.
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      112. Warburton D, Shi W. Lo, and the niche is knit: lysyl oxidase activity and maintenance of lung, aorta, and skin integrity. Am J Pathol. 2005 Oct; 167(4):921-2. PMID: 16192627; PMCID: PMC1603670.
      113. Tefft D, De Langhe SP, Del Moral PM, Sala F, Shi W, Bellusci S, Warburton D. A novel function for the protein tyrosine phosphatase Shp2 during lung branching morphogenesis. Dev Biol. 2005 Jun 15; 282(2):422-31. PMID: 15950607.
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      114. Warburton D, Bellusci S, De Langhe S, Del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W. Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res. 2005 May; 57(5 Pt 2):26R-37R. PMID: 15817505.
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      115. Phagoo SB, Reddi K, Silvallana BJ, Leeb-Lundberg LM, Warburton D. Infection-induced kinin B1 receptors in human pulmonary fibroblasts: role of intact pathogens and p38 mitogen-activated protein kinase-dependent signaling. J Pharmacol Exp Ther. 2005 Jun; 313(3):1231-8. PMID: 15743925.
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      116. Kanard RC, Fairbanks TJ, De Langhe SP, Sala FG, Del Moral PM, Lopez CA, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor-10 serves a regulatory role in duodenal development. J Pediatr Surg. 2005 Feb; 40(2):313-6. PMID: 15750921.
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      117. Fairbanks TJ, Kanard RC, Del Moral PM, Sala FG, De Langhe SP, Lopez CA, Veltmaat JM, Warburton D, Anderson KD, Bellusci S, Burns RC. Colonic atresia without mesenteric vascular occlusion. The role of the fibroblast growth factor 10 signaling pathway. J Pediatr Surg. 2005 Feb; 40(2):390-6. PMID: 15750935.
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      118. Chen C, Chen H, Sun J, Bringas P, Chen Y, Warburton D, Shi W. Smad1 expression and function during mouse embryonic lung branching morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1033-9. PMID: 15681399.
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      119. De Langhe SP, Sala FG, Del Moral PM, Fairbanks TJ, Yamada KM, Warburton D, Burns RC, Bellusci S. Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol. 2005 Jan 15; 277(2):316-31. PMID: 15617677.
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      120. Chen H, Sun J, Buckley S, Chen C, Warburton D, Wang XF, Shi W. Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L683-91. PMID: 15591413.
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      121. Fairbanks TJ, Kanard R, Del Moral PM, Sala FG, De Langhe S, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor receptor 2 IIIb invalidation--a potential cause of familial duodenal atresia. J Pediatr Surg. 2004 Jun; 39(6):872-4. PMID: 15185216.
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      122. Fairbanks TJ, De Langhe S, Sala FG, Warburton D, Anderson KD, Bellusci S, Burns RC. Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J Pediatr Surg. 2004 Mar; 39(3):360-5; discussion 360-5. PMID: 15017552.
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      123. Ding W, Bellusci S, Shi W, Warburton D. Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L52-9. PMID: 14977631.
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      124. Shi W, Chen H, Sun J, Chen C, Zhao J, Wang YL, Anderson KD, Warburton D. Overexpression of Smurf1 negatively regulates mouse embryonic lung branching morphogenesis by specifically reducing Smad1 and Smad5 proteins. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L293-300. PMID: 14711801.
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      125. Warburton D, Berberich MA, Driscoll B. Stem/progenitor cells in lung morphogenesis, repair, and regeneration. Curr Top Dev Biol. 2004; 64:1-16. PMID: 15563941.
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      126. Warburton D, Bellusci S. The molecular genetics of lung morphogenesis and injury repair. Paediatr Respir Rev. 2004; 5 Suppl A:S283-7. PMID: 14980285.
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      127. Ding W, Bellusci S, Shi W, Warburton D. Functional analysis of the human Sprouty2 gene promoter. Gene. 2003 Dec 11; 322:175-85. PMID: 14644509.
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      128. Gauldie J, Galt T, Bonniaud P, Robbins C, Kelly M, Warburton D. Transfer of the active form of transforming growth factor-beta 1 gene to newborn rat lung induces changes consistent with bronchopulmonary dysplasia. Am J Pathol. 2003 Dec; 163(6):2575-84. PMID: 14633629; PMCID: PMC3278797.
      129. Shi W, Chen H, Sun J, Buckley S, Zhao J, Anderson KD, Williams RG, Warburton D. TACE is required for fetal murine cardiac development and modeling. Dev Biol. 2003 Sep 15; 261(2):371-80. PMID: 14499647.
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      130. Reddy R, Buckley S, Doerken M, Barsky L, Weinberg K, Anderson KD, Warburton D, Driscoll B. Isolation of a putative progenitor subpopulation of alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2004 Apr; 286(4):L658-67. PMID: 12922980.
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      131. Warburton D, Bellusci S, Del Moral PM, Kaartinen V, Lee M, Tefft D, Shi W. Growth factor signaling in lung morphogenetic centers: automaticity, stereotypy and symmetry. Respir Res. 2003; 4:5. PMID: 12818006; PMCID: PMC185249.
      132. Reddi K, Phagoo SB, Anderson KD, Warburton D. Burkholderia cepacia-induced IL-8 gene expression in an alveolar epithelial cell line: signaling through CD14 and mitogen-activated protein kinase. Pediatr Res. 2003 Sep; 54(3):297-305. PMID: 12761358.
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      133. Kaartinen V, Warburton D. Fibrillin controls TGF-beta activation. Nat Genet. 2003 Mar; 33(3):331-2. PMID: 12610545.
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      134. Flores-Delgado G, Anderson KD, Warburton D. Nongenomic estrogen action regulates tyrosine phosphatase activity and tuberin stability. Mol Cell Endocrinol. 2003 Jan 31; 199(1-2):143-51. PMID: 12581886.
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      135. Huang EY, Wu H, Island ER, Chong SS, Warburton D, Anderson KD, Tuan TL. Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds. Wound Repair Regen. 2002 Nov-Dec; 10(6):387-96. PMID: 12453143.
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      136. Leinwand MJ, Tefft JD, Zhao J, Coleman C, Anderson KD, Warburton D. Nitrofen inhibition of pulmonary growth and development occurs in the early embryonic mouse. J Pediatr Surg. 2002 Sep; 37(9):1263-8. PMID: 12194114.
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      137. Leinwand MJ, Zhao J, Tefft JD, Anderson KD, Warburton D. Murine nitrofen-induced pulmonary hypoplasia does not involve induction of TGF-beta signaling. J Pediatr Surg. 2002 Aug; 37(8):1123-7. PMID: 12149686.
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      138. Warburton D. Sound the tocsin! Beware adverse effects of lung inflammation early in gestation. Am J Respir Crit Care Med. 2002 Mar 15; 165(6):741-2. PMID: 11897634.
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      139. Zhao J, Shi W, Wang YL, Chen H, Bringas P, Datto MB, Frederick JP, Wang XF, Warburton D. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002 Mar; 282(3):L585-93. PMID: 11839555.
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      140. Warburton D, Tefft D, Mailleux A, Bellusci S, Thiery JP, Zhao J, Buckley S, Shi W, Driscoll B. Do lung remodeling, repair, and regeneration recapitulate respiratory ontogeny? Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S59-62. PMID: 11734468.
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      141. Warburton D, Zhao J, Berberich MA, Bernfield M. Molecular embryology of the lung: then, now, and in the future. Am J Physiol. 1999 May; 276(5 Pt 1):L697-704. PMID: 10330024.
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      142. Warburton D, Wuenschell C, Flores-Delgado G, Anderson K. Commitment and differentiation of lung cell lineages. Biochem Cell Biol. 1998; 76(6):971-95. PMID: 10392710.
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