Michael A Schumacher

Title(s)Assistant Professor of Research Pediatrics
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
ORCID ORCID Icon0000-0003-3353-0414 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    NIDDK2022  - 2025NIH K01
    CHLA TSRI2022  - 2024Ellison RCDA
    Crohn's and Colitis Foundation2018  - 2021CDA
    Crohn's and Colitis Foundation2015  - 2018RFA
    Albert J Ryan Foundation2012  - 2014Ryan Fellowship

    Collapse Overview 
    Collapse Overview
    My lab studies fundamental immune and epithelial drivers of tissue remodeling & regeneration in the gut with a focus on discovering new ways to treat inflammatory disease like ulcerative colitis & Crohn's disease.

    Using large-scale transcriptomic datasets paired with organoid experiments and in vivo analysis, our studies address how immune signals in the intestinal tract interact with stem and crypt base secretory cells (e.g., deep crypt secretory cells) to promote intestinal health and the response to disease.
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity. Immunity. 2024 Feb 13; 57(2):319-332.e6. Eshleman EM, Rice T, Potter C, Waddell A, Hashimoto-Hill S, Woo V, Field S, Engleman L, Lim HW, Schumacher MA, Frey MR, Denson LA, Finkelman FD, Alenghat T. PMID: 38295798; PMCID: PMC10901458.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    2. Deletion of Endogenous Neuregulin-4 Limits Adaptive Immunity During Interleukin-10 Receptor-Neutralizing Colitis. Inflamm Bowel Dis. 2023 11 02; 29(11):1778-1792. Bernard JK, Bucar EB, Liu CY, Katada K, Washington MK, Schumacher MA, Frey MR. PMID: 37265326; PMCID: PMC10628918.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. The emerging roles of deep crypt secretory cells in colonic physiology. Am J Physiol Gastrointest Liver Physiol. 2023 12 01; 325(6):G493-G500. Schumacher MA. PMID: 37697924; PMCID: PMC10887841.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Deep Crypt Secretory Cell Differentiation in the Colonic Epithelium Is Regulated by Sprouty2 and Interleukin 13. Cell Mol Gastroenterol Hepatol. 2023; 15(4):971-984. Schumacher MA, Liu CY, Katada K, Thai MH, Hsieh JJ, Hansten BJ, Waddell A, Rosen MJ, Frey MR. PMID: 36414210; PMCID: PMC9982040.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    5. Sonic Hedgehog acts as a macrophage chemoattractant during regeneration of the gastric epithelium. NPJ Regen Med. 2022 Jan 12; 7(1):3. Chakrabarti J, Dua-Awereh M, Schumacher M, Engevik A, Hawkins J, Helmrath MA, Zavros Y. PMID: 35022438; PMCID: PMC8755719.
      View in: PubMed   Mentions: 7  
    6. NRG4-ErbB4 signaling represses proinflammatory macrophage activity. Am J Physiol Gastrointest Liver Physiol. 2021 06 01; 320(6):G990-G1001. Schumacher MA, Dennis IC, Liu CY, Robinson C, Shang J, Bernard JK, Washington MK, Polk DB, Frey MR. PMID: 33826403; PMCID: PMC8285586.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    7. Sprouty2 limits intestinal tuft and goblet cell numbers through GSK3β-mediated restriction of epithelial IL-33. Nat Commun. 2021 02 05; 12(1):836. Schumacher MA, Hsieh JJ, Liu CY, Appel KL, Waddell A, Almohazey D, Katada K, Bernard JK, Bucar EB, Gadeock S, Maselli KM, Washington MK, Grikscheit TC, Warburton D, Rosen MJ, Frey MR. PMID: 33547321; PMCID: PMC7864916.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    8. Growth Factors in the Intestinal Tract in Physiology of the Gastrointestinal Tract. 2018; 71-101. Michael A Schumacher, Soula Danopoulos, Denise Al Alam, Mark R Frey.
    9. The ErbB3 receptor tyrosine kinase negatively regulates Paneth cells by PI3K-dependent suppression of Atoh1. Cell Death Differ. 2017 05; 24(5):855-865. Almohazey D, Lo YH, Vossler CV, Simmons AJ, Hsieh JJ, Bucar EB, Schumacher MA, Hamilton KE, Lau KS, Shroyer NF, Frey MR. PMID: 28304405; PMCID: PMC5423110.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    10. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 02 23; 8(2):e2622. Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. PMID: 28230865; PMCID: PMC5386486.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansAnimalsCells
    11. Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells. Methods Mol Biol. 2016; 1422:23-31. Bertaux-Skeirik N, Centeno J, Feng R, Schumacher MA, Shivdasani RA, Zavros Y. PMID: 27246019.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    12. Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid. Sci Rep. 2015 Nov 24; 5:17185. Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH. PMID: 26597788; PMCID: PMC4665766.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    13. The use of murine-derived fundic organoids in studies of gastric physiology. J Physiol. 2015 Apr 15; 593(8):1809-27. Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y. PMID: 25605613; PMCID: PMC4405744.
      View in: PubMed   Mentions: 57     Fields:    Translation:AnimalsCells
    14. CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation. PLoS Pathog. 2015 Feb; 11(2):e1004663. Bertaux-Skeirik N, Feng R, Schumacher MA, Li J, Mahe MM, Engevik AC, Javier JE, Peek RM, Ottemann K, Orian-Rousseau V, Boivin GP, Helmrath MA, Zavros Y. PMID: 25658601; PMCID: PMC4450086.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    15. Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NFκB pathway activation: the use of a novel in vitro model to study epithelial response to infection. Helicobacter. 2015 Feb; 20(1):19-28. Schumacher MA, Feng R, Aihara E, Engevik AC, Montrose MH, Ottemann KM, Zavros Y. PMID: 25495001; PMCID: PMC4871133.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    16. Crosstalks between cytokines and Sonic Hedgehog in Helicobacter pylori infection: a mathematical model. PLoS One. 2014; 9(11):e111338. Marwaha S, Schumacher MA, Zavros Y, Eghbalnia HR. PMID: 25364910; PMCID: PMC4218723.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    17. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature. 2014 Dec 18; 516(7531):400-4. McCracken KW, Catá EM, Crawford CM, Sinagoga KL, Schumacher M, Rockich BE, Tsai YH, Mayhew CN, Spence JR, Zavros Y, Wells JM. PMID: 25363776; PMCID: PMC4270898.
      View in: PubMed   Mentions: 441     Fields:    Translation:HumansCells
    18. Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells. Gut. 2015 May; 64(5):720-30. Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM. PMID: 25123931; PMCID: PMC4329117.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    19. Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori. PLoS Pathog. 2014 Jul; 10(7):e1004275. Aihara E, Closson C, Matthis AL, Schumacher MA, Engevik AC, Zavros Y, Ottemann KM, Montrose MH. PMID: 25033386; PMCID: PMC4102597.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    20. Establishment of Gastrointestinal Epithelial Organoids. Curr Protoc Mouse Biol. 2013 Dec 19; 3(4):217-40. Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF. PMID: 25105065; PMCID: PMC4120977.
      View in: PubMed   Mentions: 160     Fields:    
    21. Gastritis promotes an activated bone marrow-derived mesenchymal stem cell with a phenotype reminiscent of a cancer-promoting cell. Dig Dis Sci. 2014 Mar; 59(3):569-82. Donnelly JM, Engevik AC, Engevik M, Schumacher MA, Xiao C, Yang L, Worrell RT, Zavros Y. PMID: 24202649; PMCID: PMC4301577.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    22. Sonic Hedgehog contributes to gastric mucosal restitution after injury. Lab Invest. 2013 Jan; 93(1):96-111. Xiao C, Feng R, Engevik AC, Martin JR, Tritschler JA, Schumacher M, Koncar R, Roland J, Nam KT, Goldenring JR, Zavros Y. PMID: 23090636; PMCID: PMC3730822.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. Chronic maternal infusion of full-length adiponectin in pregnant mice down-regulates placental amino acid transporter activity and expression and decreases fetal growth. J Physiol. 2012 Mar 15; 590(6):1495-509. Rosario FJ, Schumacher MA, Jiang J, Kanai Y, Powell TL, Jansson T. PMID: 22289908; PMCID: PMC3382336.
      View in: PubMed   Mentions: 51     Fields:    Translation:AnimalsCells
    24. Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology. 2012 May; 142(5):1150-1159.e6. Schumacher MA, Donnelly JM, Engevik AC, Xiao C, Yang L, Kenny S, Varro A, Hollande F, Samuelson LC, Zavros Y. PMID: 22285806; PMCID: PMC3335966.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    25. Techniques for following labeled cells in vivo: use of X/Y FISH, techniques to optimize fluorescent detection, and beta-galactosidase detection. Methods Mol Biol. 2012; 921:227-38. Craig M, Schumacher M, Zavros Y. PMID: 23015508; PMCID: PMC5030818.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    26. Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions. Am J Physiol Gastrointest Liver Physiol. 2010 Dec; 299(6):G1252-65. Xiao C, Ogle SA, Schumacher MA, Schilling N, Tokhunts RA, Orr-Asman MA, Miller ML, Robbins DJ, Hollande F, Zavros Y. PMID: 20847300; PMCID: PMC3006246.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    27. Loss of parietal cell expression of Sonic hedgehog induces hypergastrinemia and hyperproliferation of surface mucous cells. Gastroenterology. 2010 Feb; 138(2):550-61, 561.e1-8. Xiao C, Ogle SA, Schumacher MA, Orr-Asman MA, Miller ML, Lertkowit N, Varro A, Hollande F, Zavros Y. PMID: 19909751; PMCID: PMC4269486.
      View in: PubMed   Mentions: 52     Fields:    Translation:AnimalsCells
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