Stefano Da Sacco

Title(s)Assistant Professor Of Research Urology
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
ORCID ORCID Icon0000-0001-9654-6822 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University Of Padova, ItalyMS2006Pharmaceutical Chemistry
    University Of Padova/USC, Italy/USCPhD2009Tissue Engineering and Regenerative Medicine

    Collapse Overview 
    Collapse Overview
    Dr. Stefano Da Sacco is an Assistant Professor of Research Urology at the University of Southern California and an Investigator at Children's Hospital Los Angeles. He earned his PhD in tissue engineering through a joint program between the University of Padua, Italy, and the University of Southern California. Dr. Da Sacco completed his postdoctoral training in the laboratory of Dr. Roger De Filippo and Dr. Laura Perin.

    Dr. Da Sacco's research focuses on understanding the mechanisms of kidney development and disease, with a particular emphasis on the role of renal stem cells in kidney repair and regeneration. His laboratory aims to identify novel therapeutic targets and develop regenerative medicine approaches to treat kidney diseases.

    Dr. Da Sacco's lab has developed a functional glomerulus-on-a-chip platform, which models the human glomerular filtration barrier using human podocytes and glomerular endothelial cells. This innovative system allows for the study of disease mechanisms, drug testing, and biomarker discovery in a controlled environment. The glomerulus-on-a-chip has been instrumental in advancing our understanding of renal pathophysiology and holds promise for high-throughput screening of therapeutic compounds.

    Dr. Da Sacco has received research awards from NIH, ASF, and CIRM and is currently supported by NIH/NIDDK RO1s, a PNRC grant award, and Industry collaborations.

    Dr. Da Sacco is a member of several professional societies, including the American Society of Nephrology, the International Society of Glomerular Diseases, The Pediatric Nephrology Research Consortium, and ISSNAF. He serves as a reviewer for NIH study sections and the Italian Ministry of Health among others. He has published extensively in leading scientific journals and is a reviewer for several peer-reviewed publications.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of CD93 in podocytopathies.
    NEPHCURE/PNRC Grant Award Jan 1, 2025 - Dec 31, 2025
    Role: Co-PI
    Mechanisms involved in podocyte damage in Alport Syndrome
    NIH R01DK133459Aug 15, 2022 - May 31, 2027
    Role: Principal Investigator
    Novel mechanisms of glomerular injury in primary membranous nephropathy
    NIH R01DK123234Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Faculty Mentoring
    Collapse Required Scholarly Project Mentor

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease. JCI Insight. 2024 Mar 22; 9(6). Clair G, Soloyan H, Cravedi P, Angeletti A, Salem F, Al-Rabadi L, De Filippo RE, Da Sacco S, Lemley KV, Sedrakyan S, Perin L. PMID: 38516889; PMCID: PMC11063942.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy. JCI Insight. 2024 Jan 16; 9(4). Zhang Q, Bin S, Budge K, Petrosyan A, Villani V, Aguiari P, Vink C, Wetzels J, Soloyan H, La Manna G, Podestà MA, Molinari P, Sedrakyan S, Lemley KV, De Filippo RE, Perin L, Cravedi P, Da Sacco S. PMID: 38227377; PMCID: PMC11143932.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation. Ann Surg. 2023 12 01; 278(6):e1313-e1326. Rossi A, Asthana A, Riganti C, Sedrakyan S, Byers LN, Robertson J, Senger RS, Montali F, Grange C, Dalmasso A, Porporato PE, Palles C, Thornton ME, Da Sacco S, Perin L, Ahn B, McCully J, Orlando G, Bussolati B. PMID: 37450698; PMCID: PMC10631499.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    4. Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Adv Sci (Weinh). 2023 07; 10(20):e2206787. Petrosyan A, Villani V, Aguiari P, Thornton ME, Wang Y, Rajewski A, Zhou S, Cravedi P, Grubbs BH, De Filippo RE, Sedrakyan S, Lemley KV, Csete M, Da Sacco S, Perin L. PMID: 37114795; PMCID: PMC10369255.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    5. Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome. JCI Insight. 2022 01 11; 7(1). Gyarmati G, Shroff UN, Izuhara A, Hou X, Da Sacco S, Sedrakyan S, Lemley KV, Amann K, Perin L, Peti-Peterdi J. PMID: 34793332; PMCID: PMC8765042.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    6. Generation of a Glomerular Filtration Barrier on a Glomerulus-on-a-Chip Platform. Methods Mol Biol. 2022; 2373:121-131. Perin L, Da Sacco S. PMID: 34520010; PMCID: PMC10148750.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    7. Emerging Technologies to Study the Glomerular Filtration Barrier. Front Med (Lausanne). 2021; 8:772883. Gong E, Perin L, Da Sacco S, Sedrakyan S. PMID: 34901088; PMCID: PMC8655839.
      View in: PubMed   Mentions: 1  
    8. Loss of decay-accelerating factor triggers podocyte injury and glomerulosclerosis. J Exp Med. 2020 09 07; 217(9). Angeletti A, Cantarelli C, Petrosyan A, Andrighetto S, Budge K, D'Agati VD, Hartzell S, Malvi D, Donadei C, Thurman JM, Galešic-Ljubanovic D, He JC, Xiao W, Campbell KN, Wong J, Fischman C, Manrique J, Zaza G, Fiaccadori E, La Manna G, Fribourg M, Leventhal J, Da Sacco S, Perin L, Heeger PS, Cravedi P. PMID: 32717081; PMCID: PMC7478737.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    9. Author Correction: A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nat Commun. 2019 Oct 21; 10(1):4791. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. PMID: 31636254; PMCID: PMC6803622.
      View in: PubMed   Mentions: 3     Fields:    
    10. A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Nat Commun. 2019 08 13; 10(1):3656. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. PMID: 31409793; PMCID: PMC6692336.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansCells
    11. Circulating B Cells With Memory and Antibody-Secreting Phenotypes Are Detectable in Pediatric Kidney Transplant Recipients Before the Development of Antibody-Mediated Rejection. Transplant Direct. 2019 Sep; 5(9):e481. Fischman C, Fribourg M, Fabrizio G, Cioni M, Comoli P, Nocera A, Cardillo M, Cantarelli C, Gallon L, Petrosyan A, Da Sacco S, Perin L, Cravedi P. PMID: 31579809; PMCID: PMC6739044.
      View in: PubMed   Mentions: 7  
    12. Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep. 2017 12 04; 7(1):16875. Sedrakyan S, Villani V, Da Sacco S, Tripuraneni N, Porta S, Achena A, Lavarreda-Pearce M, Petrosyan A, Soloyan H, Filippo RE, Bussolati B, Perin L. PMID: 29203902; PMCID: PMC5715019.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    13. Amniotic fluid cells: current progress and emerging challenges in renal regeneration. Pediatr Nephrol. 2018 06; 33(6):935-945. Da Sacco S, Perin L, Sedrakyan S. PMID: 28620747.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    14. Direct Isolation and Characterization of Human Nephron Progenitors. Stem Cells Transl Med. 2017 02; 6(2):419-433. Da Sacco S, Thornton ME, Petrosyan A, Lavarreda-Pearce M, Sedrakyan S, Grubbs BH, De Filippo RE, Perin L. PMID: 28191781; PMCID: PMC5442819.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. A step towards clinical application of acellular matrix: A clue from macrophage polarization. Matrix Biol. 2017 01; 57-58:334-346. Petrosyan A, Da Sacco S, Tripuraneni N, Kreuser U, Lavarreda-Pearce M, Tamburrini R, De Filippo RE, Orlando G, Cravedi P, Perin L. PMID: 27575985; PMCID: PMC6717660.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    16. Decellularized Renal Matrix and Regenerative Medicine of the Kidney: A Different Point of View. Tissue Eng Part B Rev. 2016 06; 22(3):183-92. Petrosyan A, Zanusso I, Lavarreda-Pearce M, Leslie S, Sedrakyan S, De Filippo RE, Orlando G, Da Sacco S, Perin L. PMID: 26653996.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. Renal Extracellular Matrix Scaffolds From Discarded Kidneys Maintain Glomerular Morphometry and Vascular Resilience and Retains Critical Growth Factors. Transplantation. 2015 Sep; 99(9):1807-16. Peloso A, Petrosyan A, Da Sacco S, Booth C, Zambon JP, O'Brien T, Aardema C, Robertson J, De Filippo RE, Soker S, Stratta RJ, Perin L, Orlando G. PMID: 26018349.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    18. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell. 2014 Jun 05; 14(6):810-23. Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD. PMID: 24905167; PMCID: PMC4102383.
      View in: PubMed   Mentions: 227     Fields:    Translation:AnimalsCells
    19. A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. PMID: 24349133; PMCID: PMC3861313.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    20. Amniotic fluid stem cells prevent β-cell injury. Cytotherapy. 2014 Jan; 16(1):41-55. Villani V, Milanesi A, Sedrakyan S, Da Sacco S, Angelow S, Conconi MT, Di Liddo R, De Filippo R, Perin L. PMID: 24210784; PMCID: PMC4374982.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    21. β-Cell regeneration mediated by human bone marrow mesenchymal stem cells. PLoS One. 2012; 7(8):e42177. Milanesi A, Lee JW, Li Z, Da Sacco S, Villani V, Cervantes V, Perin L, Yu JS. PMID: 22879915; PMCID: PMC3413696.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    22. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. PMID: 22302195; PMCID: PMC3312511.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    23. The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. Buckley S, Shi W, Carraro G, Sedrakyan S, Da Sacco S, Driscoll BA, Perin L, De Filippo RE, Warburton D. PMID: 21700959; PMCID: PMC3262671.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Amniotic fluid as a source of pluripotent and multipotent stem cells for organ regeneration. Curr Opin Organ Transplant. 2011 Feb; 16(1):101-5. Da Sacco S, De Filippo RE, Perin L. PMID: 21157345.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    25. Regenerative medicine of the kidney. Adv Drug Deliv Rev. 2011 Apr 30; 63(4-5):379-87. Perin L, Da Sacco S, De Filippo RE. PMID: 21145933.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    26. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. PMID: 20195358; PMCID: PMC2827539.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    27. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol. 2010 Mar; 183(3):1193-200. Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. PMID: 20096867; PMCID: PMC3174101.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    28. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatr Res. 2008 May; 63(5):467-71. Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. PMID: 18427289.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    29. Characterization of human amniotic fluid stem cells and their pluripotential capability. Methods Cell Biol. 2008; 86:85-99. Perin L, Sedrakyan S, Da Sacco S, De Filippo R. PMID: 18442645.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
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