Sargis Sedrakyan

Title(s)Assistant Professor Of Research Urology
SchoolKeck School of Medicine of Usc
Address4640 West Sunset Blvd
Off Campus
Los Angeles CA 90027
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    Brooklyn College, CUNY, New YorkBS06/2003Biological Sciences
    University of Padova & USC, Italy/USAPhD04/2012Tissue Engineering and Regenerative Medicine

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    Glomerular endothelial damage: a new role of the lipids in Alport syndrome
    NIH NIDDK 1R01DK135806Dec 16, 2023 - Nov 30, 2027
    Role: Principle Investigator
    Description: This study aims to examine the role of lipids in glomerular endothelial cell dysfunction and contribution to the initiation and progression of glomerular failure in Alport syndrome. Additionally, it explores the potential of extracellular vesicles derived from amniotic fluid stem cells to rebalance lipid levels, with the ultimate goal of restoring proper function to the glomerular filtration barrier.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kidney Endothelial Cell Biology in Health and Disease. J Am Soc Nephrol. 2024 Apr 08. Sedrakyan S. PMID: 38588513.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The spatially resolved transcriptome signatures of glomeruli in chronic kidney disease. JCI Insight. 2024 Mar 22; 9(6). Clair G, Soloyan H, Cravedi P, Angeletti A, Salem F, Al-Rabadi L, De Filippo RE, Da Sacco S, Lemley KV, Sedrakyan S, Perin L. PMID: 38516889.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy. JCI Insight. 2024 Jan 16; 9(4). Zhang Q, Bin S, Budge K, Petrosyan A, Villani V, Aguiari P, Vink C, Wetzels J, Soloyan H, La Manna G, Podestà MA, Molinari P, Sedrakyan S, Lemley KV, De Filippo RE, Perin L, Cravedi P, Da Sacco S. PMID: 38227377.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Extracellular vesicles in kidney development and pediatric kidney diseases. Pediatr Nephrol. 2023 Sep 29. Ergunay T, Collino F, Bianchi G, Sedrakyan S, Perin L, Bussolati B. PMID: 37775581.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Mitochondria Transplantation Mitigates Damage in an In Vitro Model of Renal Tubular Injury and in an Ex Vivo Model of DCD Renal Transplantation. Ann Surg. 2023 12 01; 278(6):e1313-e1326. Rossi A, Asthana A, Riganti C, Sedrakyan S, Byers LN, Robertson J, Senger RS, Montali F, Grange C, Dalmasso A, Porporato PE, Palles C, Thornton ME, Da Sacco S, Perin L, Ahn B, McCully J, Orlando G, Bussolati B. PMID: 37450698; PMCID: PMC10631499.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    6. Identification and Characterization of the Wilms Tumor Cancer Stem Cell. Adv Sci (Weinh). 2023 07; 10(20):e2206787. Petrosyan A, Villani V, Aguiari P, Thornton ME, Wang Y, Rajewski A, Zhou S, Cravedi P, Grubbs BH, De Filippo RE, Sedrakyan S, Lemley KV, Csete M, Da Sacco S, Perin L. PMID: 37114795; PMCID: PMC10369255.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Intravital imaging reveals glomerular capillary distension and endothelial and immune cell activation early in Alport syndrome. JCI Insight. 2022 01 11; 7(1). Gyarmati G, Shroff UN, Izuhara A, Hou X, Da Sacco S, Sedrakyan S, Lemley KV, Amann K, Perin L, Peti-Peterdi J. PMID: 34793332; PMCID: PMC8765042.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    8. Emerging Technologies to Study the Glomerular Filtration Barrier. Front Med (Lausanne). 2021; 8:772883. Gong E, Perin L, Da Sacco S, Sedrakyan S. PMID: 34901088; PMCID: PMC8655839.
      View in: PubMed   Mentions: 1  
    9. The spatially resolved transcriptional profile of acute T cell-mediated rejection in a kidney allograft. Kidney Int. 2022 01; 101(1):131-136. Salem F, Perin L, Sedrakyan S, Angeletti A, Ghiggeri GM, Coccia MC, Ross M, Fribourg M, Cravedi P. PMID: 34555393; PMCID: PMC9387544.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    10. Glomerular endothelial cell heterogeneity in Alport syndrome. Sci Rep. 2020 07 10; 10(1):11414. Soloyan H, Thornton M, Villani V, Khatchadourian P, Cravedi P, Angeletti A, Grubbs B, De Filippo R, Perin L, Sedrakyan S. PMID: 32651395; PMCID: PMC7351764.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    11. Amniotic fluid stem cell-derived vesicles protect from VEGF-induced endothelial damage. Sci Rep. 2017 12 04; 7(1):16875. Sedrakyan S, Villani V, Da Sacco S, Tripuraneni N, Porta S, Achena A, Lavarreda-Pearce M, Petrosyan A, Soloyan H, Filippo RE, Bussolati B, Perin L. PMID: 29203902; PMCID: PMC5715019.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    12. Thyroid Hormone Receptor Alpha is Essential to Maintain the Satellite Cell Niche During Skeletal Muscle Injury and Sarcopenia of Aging. Thyroid. 2017 10; 27(10):1316-1322. Milanesi A, Lee JW, Yang A, Liu YY, Sedrakyan S, Cheng SY, Perin L, Brent GA. PMID: 28847239; PMCID: PMC5649408.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    13. Amniotic fluid cells: current progress and emerging challenges in renal regeneration. Pediatr Nephrol. 2018 06; 33(6):935-945. Da Sacco S, Perin L, Sedrakyan S. PMID: 28620747.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    14. Direct Isolation and Characterization of Human Nephron Progenitors. Stem Cells Transl Med. 2017 02; 6(2):419-433. Da Sacco S, Thornton ME, Petrosyan A, Lavarreda-Pearce M, Sedrakyan S, Grubbs BH, De Filippo RE, Perin L. PMID: 28191781; PMCID: PMC5442819.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    15. Decellularized Renal Matrix and Regenerative Medicine of the Kidney: A Different Point of View. Tissue Eng Part B Rev. 2016 06; 22(3):183-92. Petrosyan A, Zanusso I, Lavarreda-Pearce M, Leslie S, Sedrakyan S, De Filippo RE, Orlando G, Da Sacco S, Perin L. PMID: 26653996.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Thyroid Hormone Receptor α Plays an Essential Role in Male Skeletal Muscle Myoblast Proliferation, Differentiation, and Response to Injury. Endocrinology. 2016 Jan; 157(1):4-15. Milanesi A, Lee JW, Kim NH, Liu YY, Yang A, Sedrakyan S, Kahng A, Cervantes V, Tripuraneni N, Cheng SY, Perin L, Brent GA. PMID: 26451739; PMCID: PMC4701883.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    17. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
      View in: PubMed   Mentions: 366     Fields:    Translation:HumansAnimals
    18. A novel source of cultured podocytes. PLoS One. 2013; 8(12):e81812. Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L. PMID: 24349133; PMCID: PMC3861313.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    19. Amniotic fluid stem cells prevent β-cell injury. Cytotherapy. 2014 Jan; 16(1):41-55. Villani V, Milanesi A, Sedrakyan S, Da Sacco S, Angelow S, Conconi MT, Di Liddo R, De Filippo R, Perin L. PMID: 24210784; PMCID: PMC4374982.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    20. Amniotic fluid stem cells inhibit the progression of bleomycin-induced pulmonary fibrosis via CCL2 modulation in bronchoalveolar lavage. PLoS One. 2013; 8(8):e71679. Garcia O, Carraro G, Turcatel G, Hall M, Sedrakyan S, Roche T, Buckley S, Driscoll B, Perin L, Warburton D. PMID: 23967234; PMCID: PMC3742516.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    21. Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. 2012 Apr; 23(4):661-73. Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L. PMID: 22302195; PMCID: PMC3312511.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    22. Stem cells as a therapeutic approach to chronic kidney diseases. Curr Urol Rep. 2012 Feb; 13(1):47-54. Sedrakyan S, Angelow S, De Filippo RE, Perin L. PMID: 22127675.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    23. The milieu of damaged alveolar epithelial type 2 cells stimulates alveolar wound repair by endogenous and exogenous progenitors. Am J Respir Cell Mol Biol. 2011 Dec; 45(6):1212-21. Buckley S, Shi W, Carraro G, Sedrakyan S, Da Sacco S, Driscoll BA, Perin L, De Filippo RE, Warburton D. PMID: 21700959; PMCID: PMC3262671.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    24. Protective effect of human amniotic fluid stem cells in an immunodeficient mouse model of acute tubular necrosis. PLoS One. 2010 Feb 24; 5(2):e9357. Perin L, Sedrakyan S, Giuliani S, Da Sacco S, Carraro G, Shiri L, Lemley KV, Rosol M, Wu S, Atala A, Warburton D, De Filippo RE. PMID: 20195358; PMCID: PMC2827539.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    25. Human amniotic fluid as a potential new source of organ specific precursor cells for future regenerative medicine applications. J Urol. 2010 Mar; 183(3):1193-200. Da Sacco S, Sedrakyan S, Boldrin F, Giuliani S, Parnigotto P, Habibian R, Warburton D, De Filippo RE, Perin L. PMID: 20096867; PMCID: PMC3174101.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    26. Human amniotic fluid stem cells can integrate and differentiate into epithelial lung lineages. Stem Cells. 2008 Nov; 26(11):2902-11. Carraro G, Perin L, Sedrakyan S, Giuliani S, Tiozzo C, Lee J, Turcatel G, De Langhe SP, Driscoll B, Bellusci S, Minoo P, Atala A, De Filippo RE, Warburton D. PMID: 18719226; PMCID: PMC3174105.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    27. Stem cell and regenerative science applications in the development of bioengineering of renal tissue. Pediatr Res. 2008 May; 63(5):467-71. Perin L, Giuliani S, Sedrakyan S, DA Sacco S, De Filippo RE. PMID: 18427289.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    28. Characterization of human amniotic fluid stem cells and their pluripotential capability. Methods Cell Biol. 2008; 86:85-99. Perin L, Sedrakyan S, Da Sacco S, De Filippo R. PMID: 18442645.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    29. Renal differentiation of amniotic fluid stem cells. Cell Prolif. 2007 Dec; 40(6):936-48. Perin L, Giuliani S, Jin D, Sedrakyan S, Carraro G, Habibian R, Warburton D, Atala A, De Filippo RE. PMID: 18021180; PMCID: PMC6495686.
      View in: PubMed   Mentions: 65     Fields:    Translation:HumansAnimalsCells
    30. Ex vivo whole embryonic kidney culture: a novel method for research in development, regeneration and transplantation. J Urol. 2008 Jan; 179(1):365-70. Giuliani S, Perin L, Sedrakyan S, Kokorowski P, Jin D, De Filippo R. PMID: 18006007.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    31. Tissue engineering of a small hand phalanx with a porously casted polylactic acid-polyglycolic acid copolymer. Tissue Eng. 2006 Sep; 12(9):2675-83. Sedrakyan S, Zhou ZY, Perin L, Leach K, Mooney D, Kim TH. PMID: 16995801.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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