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Pinchas Cohen, MD

Photo of Pinchas Cohen, MD
Title(s)Dean, USC Leonard C. Davis School of Gerontology
SchoolSchool of Gerontology
AddressGER 103
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1354
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    The University of Southern California and Buck Institute Nathan Shock Center
    NIH P30AG068345Sep 15, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Metformin-Regulated Mitochondrial Peptides and their Effects on Aging
    NIH R01AG069698Sep 15, 2020 - May 31, 2025
    Role: Principal Investigator
    Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and Dementia
    NIH R01AG068405Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Ethnic-Specific Mitochondrial DNA Variations that Contribute to Dementia
    NIH R56AG062693Aug 15, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Humanin is an AD resilience factor through its interaction with APOE4
    NIH RF1AG061834Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Role of GPR120 and Macrophages in Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer
    NIH R01CA231219Sep 17, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Plasma Mitochondrial Peptide Assays as Biomarkers of Environmental Toxin Exposure
    NIH R01ES020812Sep 19, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Humanin and Type 2 Diabetes
    NIH R21DK089447Sep 1, 2011 - Aug 31, 2013
    Role: Co-Principal Investigator
    Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
    NIH R01GM090311Sep 30, 2009 - Mar 31, 2016
    Role: Principal Investigator
    A family of novel mitochondrially-encoded peptides and their role in aging
    NIH R01AG034430Jul 15, 2009 - Jun 30, 2014
    Role: Principal Investigator
    The Role of IGF2 in Fetal Growth Restriction
    NIH R01HD047013Jun 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    NIH R01CA100938Jun 13, 2003 - May 31, 2008
    Role: Principal Investigator
    Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    NIH R01AG020954Sep 30, 2001 - Aug 31, 2006
    Role: Principal Investigator
    IGF AXIS IN ASTHMA
    NIH R01AI040203Apr 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    IGF AXIS ABNORMALITIES IN BPH
    NIH R01DK047591Sep 30, 1993 - Aug 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitochondrial-derived microproteins in lung disease: insights and implications. Am J Physiol Lung Cell Mol Physiol. 2026 Mar 01; 330(3):L222-L231. Behan M, Yen K, Cohen P, Kliment CR. PMID: 41569667; PMCID: PMC12961588.
      View in: PubMed   Mentions:
    2. Systemic MOTS-c levels are increased in adults with obesity in association with metabolic dysregulation and remain unchanged after weight loss. J Clin Transl Endocrinol. 2026 Feb; 43:100429. Yoon SH, Yuan F, Zhu X, Tang H, Abdurakhimoova D, Krier J, Eirin A, Lerman A, Cohen P, Lerman LO. PMID: 41551324; PMCID: PMC12807633.
      View in: PubMed   Mentions:
    3. Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer. Neoplasia. 2025 Dec; 70:101245. Soni S, Mittal P, Lo JH, Yang Y, Smbatyan G, Lee K, Wan J, Kumagai H, Yen K, Mehta HH, Miller B, Torres-Gonzalez L, Battaglin F, Shah UH, Bartolini M, Zhang W, Craig DW, Millstein J, Cohen P, Lenz HJ. PMID: 41201920; PMCID: PMC12596543.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Mitochondrial DNA Copy-Number Assessment Is a Potent Predictor for Prostate Cancer in White but Not Black Individuals. Cancer Prev Res (Phila). 2025 Sep 02; 18(9):541-550. Flores MK, Janes JL, Islam M, Wan J, Liu J, Reams RR, Su LM, Yen K, Mehta HH, Reagan A, Howard LE, Wiggins E, Vidal AC, Freedland SJ, Cohen P. PMID: 40358482; PMCID: PMC12354066.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Mitochondrial-derived microproteins: from discovery to function: (Trends in Genetics, 41:2 pp:132-145, 2025). Trends Genet. 2025 Apr; 41(4):357. Yen K, Miller B, Kumagai H, Silverstein A, Cohen P. PMID: 40050129.
      View in: PubMed   Mentions:    Fields:    
    6. Mitochondrial-derived microproteins: from discovery to function. Trends Genet. 2025 Feb; 41(2):132-145. Yen K, Miller B, Kumagai H, Silverstein A, Cohen P. PMID: 39690001; PMCID: PMC11794013.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    7. High Omega-3, Low Omega-6 Diet With Fish Oil for Men With Prostate Cancer on Active Surveillance: The CAPFISH-3 Randomized Clinical Trial. J Clin Oncol. 2025 Mar; 43(7):800-809. Aronson WJ, Grogan T, Liang P, Jardack P, Liddell AR, Perez C, Elashoff D, Said J, Cohen P, Marks LS, Henning SM. PMID: 39671538; PMCID: PMC11869882.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    8. MOTS-c modulates skeletal muscle function by directly binding and activating CK2. iScience. 2024 Nov 15; 27(11):111212. Kumagai H, Kim SJ, Miller B, Zempo H, Tanisawa K, Natsume T, Lee SH, Wan J, Leelaprachakul N, Kumagai ME, Ramirez R, Mehta HH, Cao K, Oh TJ, Wohlschlegel JA, Sha J, Nishida Y, Fuku N, Dobashi S, Miyamoto-Mikami E, Takaragawa M, Fuku M, Yoshihara T, Naito H, Kawakami R, Torii S, Midorikawa T, Oka K, Hara M, Iwasaka C, Yamada Y, Higaki Y, Tanaka K, Yen K, Cohen P. PMID: 39559755; PMCID: PMC11570452.
      View in: PubMed   Mentions: 3  
    9. Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology. Aging Cell. 2024 Jul; 23(7):e14153. Miller B, Kim SJ, Cao K, Mehta HH, Thumaty N, Kumagai H, Iida T, McGill C, Pike CJ, Nurmakova K, Levine ZA, Sullivan PM, Yen K, Ertekin-Taner N, Atzmon G, Barzilai N, Cohen P. PMID: 38520065; PMCID: PMC11258485.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    10. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024 Feb 20; 15(1):1309. Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. PMID: 38378685; PMCID: PMC10879164.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    11. A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Mol Psychiatry. 2024 02; 29(2):505-517. Kim SJ, Miller B, Hartel NG, Ramirez R, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. PMID: 38167865; PMCID: PMC11116102.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration. Am J Physiol Endocrinol Metab. 2024 Mar 01; 326(3):E207-E214. Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R, Lee SH, Sato A, Mehta HH, Yen K, Cohen P. PMID: 38170165; PMCID: PMC11196098.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    13. Effect of omega-3 fatty acid diet on prostate cancer progression and cholesterol efflux in tumor-associated macrophages-dependence on GPR120. Prostate Cancer Prostatic Dis. 2024 Dec; 27(4):700-708. Liang P, Henning SM, Grogan T, Elashoff D, Said J, Cohen P, Aronson WJ. PMID: 37872251; PMCID: PMC11035487.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr; 28(4):1827. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36658336.
      View in: PubMed   Mentions: 1     Fields:    
    15. Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases. Genes (Basel). 2023 01 21; 14(2). Kumagai H, Miller B, Kim SJ, Leelaprachakul N, Kikuchi N, Yen K, Cohen P. PMID: 36833212; PMCID: PMC9956216.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    16. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes. Cancer Control. 2023 Jan-Dec; 30:10732748231197878. Reams RR, Odedina FT, Carpten JD, Redda K, Stern MC, Krieger JL, Aparicio J, Hensel B, Askins N, Abreu A, Adams A, Agyare E, Ali J, Allen JM, Aló R, Baezconde-Garbanati L, Brant J, Brown CP, Buxbaum SG, Cohen P, Cozen W, Ezenwa MO, Falzarano S, Fillingim RB, Flores-Rozas H, Fredenburg KM, George T, Han B, Huang Y, Hughes Halbert C, Kiros GE, Lamango NS, Lee JH, Lyon DE, Mitchell DA, Mochona B, Nieva JJ, Offringa IA, Okunieff P, Parker A, Rhie SK, Richey JM, Rogers SC, Salhia B, Schmittgen TD, Segal R, Setiawan VW, Smith U, Su LM, Suther S, Trevino J, Velazquez-Villarreal EI, Webb FJ, Wu AH, Yao Y, Wilkie DJ. PMID: 37703814; PMCID: PMC10501072.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    17. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022 09 27; 40(13):111417. Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, Boccardi V, Mecocci P, Pike CJ, Cohen P, LaDu MJ, Pellegrini M, Xia K, Tran K, Ann B, Chowdhury D, Longo VD. PMID: 36170815; PMCID: PMC9648488.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    18. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 04; 28(4):1813-1826. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*. PMID: 36127429; PMCID: PMC10027624.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    19. Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities. Prostate. 2022 09; 82(13):1248-1257. Ramirez-Torres A, Reagan AL, Howard LE, Wiggins E, Vidal AC, Wan J, Miller B, Freedland SJ, Cohen P. PMID: 35789022; PMCID: PMC9388542.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). Aging (Albany NY). 2022 05 16; 14(10):4247-4269. Nashine S, Cohen P, Wan J, Kenney MC. PMID: 35576057; PMCID: PMC9186758.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    21. Mitochondria-derived peptides in aging and healthspan. J Clin Invest. 2022 05 02; 132(9). Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. PMID: 35499074; PMCID: PMC9057581.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    22. Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time. Sci Rep. 2022 04 01; 12(1):5518. Xu T, Junge JA, Delfarah A, Lu YT, Arnesano C, Iqbal M, Delijani K, Hsieh TC, Hodara E, Mehta HH, Cohen P, Graham NA, Fraser SE, Goldkorn A. PMID: 35365706; PMCID: PMC8976067.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    23. Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120. Prostate Cancer Prostatic Dis. 2022 09; 25(3):539-546. Liang P, Henning SM, Grogan T, Elashoff D, Ye H, Cohen P, Aronson WJ. PMID: 35075215; PMCID: PMC9308823.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    24. The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj. 2022 Feb; 1866(2):130048. Kumagai H, Natsume T, Kim SJ, Tobina T, Miyamoto-Mikami E, Shiose K, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Miller B, Yen K, Murakami H, Miyachi M, Zempo H, Dobashi S, Machida S, Kobayashi H, Naito H, Cohen P, Fuku N. PMID: 34728329; PMCID: PMC8741734.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    25. Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension. Biochim Biophys Acta Gen Subj. 2022 01; 1866(1):130017. Kim SJ, Devgan A, Miller B, Lee SM, Kumagai H, Wilson KA, Wassef G, Wong R, Mehta HH, Cohen P, Yen K. PMID: 34624450; PMCID: PMC8595716.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 01; 1507(1):70-83. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. PMID: 34498278; PMCID: PMC10231756.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    27. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. Biochim Biophys Acta Gen Subj. 2021 11; 1865(11):129991. Sequeira IR, Woodhead JST, Chan A, D'Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, Merry TL. PMID: 34419510.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    28. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021 08 19; 11(1):16916. Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, Cohen P. PMID: 34413391; PMCID: PMC8376922.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    29. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. J Appl Physiol (1985). 2021 09 01; 131(3):1035-1042. von Walden F, Fernandez-Gonzalo R, Norrbom J, Emanuelsson EB, Figueiredo VC, Gidlund EK, Norrbrand L, Liu C, Sandström P, Hansson B, Wan J, Cohen P, Alkner B. PMID: 34351816.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    30. The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†. Biol Reprod. 2021 03 11; 104(3):717-730. Jia Y, Swerdloff RS, Lue Y, Dai-Ju J, Surampudi P, Cohen P, Wang C. PMID: 33330922; PMCID: PMC8527998.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    31. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E680-E690. Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. PMID: 33554779; PMCID: PMC8238132.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    32. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 01 20; 12(1):470. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. PMID: 33473109; PMCID: PMC7817689.
      View in: PubMed   Mentions: 95     Fields:    Translation:HumansAnimalsCells
    33. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY). 2021 01 19; 13(2):1692-1717. Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. PMID: 33468709; PMCID: PMC7880332.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansAnimalsCells
    34. Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples. Sci Rep. 2021 01 08; 11(1):3. Miller B, Silverstein A, Flores M, Cao K, Kumagai H, Mehta HH, Yen K, Kim SJ, Cohen P. PMID: 33420163; PMCID: PMC7794290.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    35. Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway. Mol Ther Nucleic Acids. 2021 Mar 05; 23:264-276. Zhao Y, Zhou L, Li H, Sun T, Wen X, Li X, Meng Y, Li Y, Liu M, Liu S, Kim SJ, Xiao J, Li L, Zhang S, Li W, Cohen P, Hoffman AR, Hu JF, Cui J. PMID: 33425485; PMCID: PMC7773746.
      View in: PubMed   Mentions: 74  
    36. Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system. Transl Med Aging. 2020; 4:132-140. Silverstein AR, Flores MK, Miller B, Kim SJ, Yen K, Mehta HH, Cohen P. PMID: 32844137; PMCID: PMC7441040.
      View in: PubMed   Mentions: 1  
    37. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    38. A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population. Transl Vis Sci Technol. 2020 05; 9(6):25. Miller B, Torres M, Jiang X, McKean-Cowdin R, Nousome D, Kim SJ, Mehta HH, Yen K, Cohen P, Varma R. PMID: 32821522; PMCID: PMC7408807.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    39. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp Cell Res. 2020 08 15; 393(2):112056. Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, Yen K, Cohen P. PMID: 32387288; PMCID: PMC7778388.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    40. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985). 2020 05 01; 128(5):1346-1354. Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL. PMID: 32271093; PMCID: PMC7717117.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimals
    41. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY). 2020 03 17; 12(6):5244-5258. D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. PMID: 32182209; PMCID: PMC7138593.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    42. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019; 92(1):1-14. Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J. PMID: 31514194; PMCID: PMC6979443.
      View in: PubMed   Mentions: 152     Fields:    Translation:Humans
    43. Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages. Prostate Cancer Prostatic Dis. 2020 03; 23(1):127-135. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 31439889; PMCID: PMC7031053.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    44. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 07; 7(13):e14171. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. PMID: 31293078; PMCID: PMC6640593.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    45. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 06 06; 15(6):88. Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. PMID: 31172328; PMCID: PMC6554247.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    46. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. PMID: 30980914; PMCID: PMC6506186.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    47. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 04 03; 8(4). Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. PMID: 30987182; PMCID: PMC6523867.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    48. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 04 03; 9(1):5546. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. PMID: 30944385; PMCID: PMC6447602.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    49. MOTS-c: an equal opportunity insulin sensitizer. J Mol Med (Berl). 2019 04; 97(4):487-490. Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. PMID: 30788534; PMCID: PMC6462348.
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    50. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. FASEB J. 2019 04; 33(4):4962-4974. Zaman F, Zhao Y, Celvin B, Mehta HH, Wan J, Chrysis D, Ohlsson C, Fadeel B, Cohen P, Sävendahl L. PMID: 30657335; PMCID: PMC6988867.
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    51. Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. J Natl Cancer Inst. 2019 01 01; 111(1):52-59. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ. PMID: 30202902; PMCID: PMC6335116.
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    52. Growth hormone therapy in children; research and practice - A review. Growth Horm IGF Res. 2019 02; 44:20-32. Collett-Solberg PF, Jorge AAL, Boguszewski MCS, Miller BS, Choong CSY, Cohen P, Hoffman AR, Luo X, Radovick S, Saenger P. PMID: 30605792.
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    53. Mitochondrial biology and prostate cancer ethnic disparity. Carcinogenesis. 2018 12 13; 39(11):1311-1319. Xiao J, Cohen P, Stern MC, Odedina F, Carpten J, Reams R. PMID: 30304372; PMCID: PMC6292412.
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    54. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 10 11; 8(1):15175. Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 30310092; PMCID: PMC6182005.
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    55. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
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    56. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1127-H1136. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. PMID: 30004252; PMCID: PMC6415743.
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    57. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun. 2018 06 19; 9(1):2394. Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM. PMID: 29921922; PMCID: PMC6008442.
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    58. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018 Jun 10; 10(6):1239-1256. Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P. PMID: 29886458; PMCID: PMC6046248.
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    59. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905; PMCID: PMC5745211.
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    60. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018 03 01; 254:23-27. Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. PMID: 29242099.
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    61. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis. 2018 06; 21(2):212-220. Henning SM, Galet C, Gollapudi K, Byrd JB, Liang P, Li Z, Grogan T, Elashoff D, Magyar CE, Said J, Cohen P, Aronson WJ. PMID: 29203893; PMCID: PMC5986584.
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    62. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. J Vis Exp. 2017 09 25; (127). Kim SJ, Xiao J, Cohen P, Yen K. PMID: 28994791; PMCID: PMC5752322.
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    63. Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk. Oncotarget. 2017 Nov 07; 8(55):94900-94909. Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ. PMID: 29212276; PMCID: PMC5706922.
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    64. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep. 2017 08 10; 7(1):7802. Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. PMID: 28798389; PMCID: PMC5552803.
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    65. Feeling misguided: a comment on the US guidelines on growth hormone and insulin-like growth factor-I treatment in children and adolescents. Curr Opin Pediatr. 2017 08; 29(4):472-474. Saenger P, Cohen P. PMID: 28604412.
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    66. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 07 20; 8(7):e2951. Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 28726777; PMCID: PMC5550888.
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    68. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017 06; 3(6):e1602025. Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, Atzmon G. PMID: 28630896; PMCID: PMC5473676.
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    69. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635; PMCID: PMC5722247.
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    70. Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells. Stem Cells Int. 2017; 2017:1764549. Yu D, Du Z, Pian L, Li T, Wen X, Li W, Kim SJ, Xiao J, Cohen P, Cui J, Hoffman AR, Hu JF. PMID: 28484495; PMCID: PMC5397648.
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    73. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
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    74. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton DR. PMID: 27783653; PMCID: PMC5081188.
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    76. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. PMID: 27384491; PMCID: PMC5216912.
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    77. Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression. Prostate. 2016 10; 76(14):1293-302. Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 27338236; PMCID: PMC5081258.
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    78. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 06 14; 23(6):1093-1112. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. PMID: 27304509; PMCID: PMC4911707.
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    81. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 04; 8(4):796-809. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. PMID: 27070352; PMCID: PMC4925829.
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    83. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. PMID: 26990160; PMCID: PMC4811181.
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    84. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell. 2016 Feb; 15(1):181-6. Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N. PMID: 26534869; PMCID: PMC4717281.
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    85. The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology. 2015 Dec; 156(12):4511-21. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C. PMID: 26384090; PMCID: PMC4655208.
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    87. Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Mol Cell Endocrinol. 2015 Sep 15; 413:96-100. Paharkova V, Alvarez G, Nakamura H, Cohen P, Lee KW. PMID: 26116236.
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    92. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
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    93. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Apr; 221(1):145-55. Moody G, Beltran PJ, Mitchell P, Cajulis E, Chung YA, Hwang D, Kendall R, Radinsky R, Cohen P, Calzone FJ. PMID: 24492468; PMCID: PMC4160154.
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    95. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
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    96. New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. J Natl Cancer Inst. 2014 Mar; 106(3):dju006. Cohen P. PMID: 24586106; PMCID: PMC3982780.
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    112. Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts. Mol Cancer Ther. 2012 Jul; 11(7):1539-46. Konijeti R, Koyama S, Gray A, Barnard RJ, Said JW, Castor B, Elashoff D, Wan J, Beltran PJ, Calzone FJ, Cohen P, Galet C, Aronson WJ. PMID: 22562985; PMCID: PMC3392522.
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    114. Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab. 2012 Jan; 97(1):68-72. Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM. PMID: 22174422.
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    115. Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res (Phila). 2011 Dec; 4(12):2062-71. Aronson WJ, Kobayashi N, Barnard RJ, Henning S, Huang M, Jardack PM, Liu B, Gray A, Wan J, Konijeti R, Freedland SJ, Castor B, Heber D, Elashoff D, Said J, Cohen P, Galet C. PMID: 22027686; PMCID: PMC3232341.
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    116. Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model. J Endocrinol. 2011 Dec; 211(3):297-304. Gray A, Aronson WJ, Barnard RJ, Mehta H, Wan J, Said J, Cohen P, Galet C. PMID: 21903863; PMCID: PMC3271951.
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    117. Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice. Growth Horm IGF Res. 2011 Oct; 21(5):243-7. Mason EJ, Grell JA, Wan J, Cohen P, Conover CA. PMID: 21802327; PMCID: PMC3171618.
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    118. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 2011 Nov; 219(1):65-73. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A. PMID: 21763658; PMCID: PMC3885346.
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    119. IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 2011 Aug 01; 71(15):5154-63. Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW. PMID: 21697285; PMCID: PMC3148406.
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    120. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. PMID: 21325617; PMCID: PMC3357623.
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    121. Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis. Endocrinology. 2011 Jan; 152(1):172-80. Williams NG, Interlichia JP, Jackson MF, Hwang D, Cohen P, Rodgers BD. PMID: 21147879; PMCID: PMC3219050.
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    122. Chemoprevention of prostate cancer with lycopene in the TRAMP model. Prostate. 2010 Oct 01; 70(14):1547-54. Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, Shapiro A, Ku M, Said JW, Heber D, Cohen P, Aronson WJ. PMID: 20687227; PMCID: PMC2930120.
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    123. Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. Prostate. 2010 Jul 01; 70(10):1037-43. Buschemeyer WC, Klink JC, Mavropoulos JC, Poulton SH, Demark-Wahnefried W, Hursting SD, Cohen P, Hwang D, Johnson TL, Freedland SJ. PMID: 20166128.
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    124. Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res. 2010 Nov 01; 88(2):360-6. Bachar AR, Scheffer L, Schroeder AS, Nakamura HK, Cobb LJ, Oh YK, Lerman LO, Pagano RE, Cohen P, Lerman A. PMID: 20562421; PMCID: PMC2952532.
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    125. Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children. J Clin Endocrinol Metab. 2010 May; 95(5):2089-98. Cohen P, Germak J, Rogol AD, Weng W, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group. PMID: 20207829.
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    126. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. PMID: 20145127; PMCID: PMC2836202.
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    127. Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. J Urol. 2010 Jan; 183(1):345-50. Aronson WJ, Barnard RJ, Freedland SJ, Henning S, Elashoff D, Jardack PM, Cohen P, Heber D, Kobayashi N. PMID: 19914662; PMCID: PMC3089950.
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    128. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. PMID: 20157582; PMCID: PMC2815756.
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    129. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010 Jan; 151(1):350-7. Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. PMID: 19952275.
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    130. Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem. 2010 Jan 15; 285(3):1726-32. Jia Y, Lee KW, Swerdloff R, Hwang D, Cobb LJ, Sinha Hikim A, Lue YH, Cohen P, Wang C. PMID: 19887447; PMCID: PMC2804330.
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    131. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm IGF Res. 2010 Feb; 20(1):55-62. Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. PMID: 19853487; PMCID: PMC2815223.
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    132. The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism. 2010 Mar; 59(3):343-9. Hoang PT, Park P, Cobb LJ, Paharkova-Vatchkova V, Hakimi M, Cohen P, Lee KW. PMID: 19800083; PMCID: PMC2932671.
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    133. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22; 4(7):e6334. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. PMID: 19623253; PMCID: PMC2709436.
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    134. Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation. Mol Endocrinol. 2009 Oct; 23(10):1624-33. Cobb LJ, Mehta H, Cohen P. PMID: 19556345; PMCID: PMC2754899.
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    135. The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila). 2009 Jun; 2(6):557-65. Mavropoulos JC, Buschemeyer WC, Tewari AK, Rokhfeld D, Pollak M, Zhao Y, Febbo PG, Cohen P, Hwang D, Devi G, Demark-Wahnefried W, Westman EC, Peterson BL, Pizzo SV, Freedland SJ. PMID: 19470786; PMCID: PMC3774034.
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    136. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 2009 Jul 24; 284(30):19937-44. Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA. PMID: 19460757; PMCID: PMC2740419.
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    137. Optimizing growth hormone dosing in children with idiopathic short stature. Horm Res. 2009 Jan; 71 Suppl 1:70-4. Keni J, Cohen P. PMID: 19153511.
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    138. PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions. Mol Endocrinol. 2009 Feb; 23(2):169-75. Miyako K, Cobb LJ, Francis M, Huang A, Peng B, Pintar JE, Ariga H, Cohen P. PMID: 19095771; PMCID: PMC2646620.
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    139. Surprising new height regulating genes: beyond growth hormone and IGF-I. Pediatr Res. 2008 Nov; 64(5):461. Hernández MI, Cohen P. PMID: 18931612.
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    140. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. PMID: 18952711; PMCID: PMC2653987.
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    141. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res. 2008 May 01; 68(9):3342-9. Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. PMID: 18451161; PMCID: PMC2928555.
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    143. Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature. Pediatr Endocrinol Rev. 2008 Apr; 5 Suppl 3:834-6. Cohen P. PMID: 18438325.
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    144. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3438-42. Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. PMID: 18316725; PMCID: PMC2265137.
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    146. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007 Nov 15; 67(22):11083-91. Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R. PMID: 18006855.
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    148. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. Eur J Cancer Prev. 2007 Oct; 16(5):415-21. Barnard RJ, Leung PS, Aronson WJ, Cohen P, Golding LA. PMID: 17923812.
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    149. Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth Horm IGF Res. 2008 Feb; 18(1):65-74. Hwang DL, Lee PD, Cohen P. PMID: 17719253; PMCID: PMC2276237.
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    150. Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency. Pediatr Endocrinol Rev. 2007 May; 4 Suppl 2:252-71. Rosenthal S, Cohen P, Clayton P, Backeljauw P, Bang P, Ten S. PMID: 17581497.
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    151. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007 Aug; 28(8):1653-8. Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P. PMID: 17434920.
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    154. Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study. J Clin Endocrinol Metab. 2007 Mar; 92(3):932-7. Ali O, Shim M, Fowler E, Greenberg M, Perkins D, Oppenheim W, Cohen P. PMID: 17179200.
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    155. Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res. 2006 Nov 15; 66(22):10878-84. Cobb LJ, Liu B, Lee KW, Cohen P. PMID: 17108124.
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    158. Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. Int J Cancer. 2006 Sep 01; 119(5):1039-46. Benini S, Zuntini M, Manara MC, Cohen P, Nicoletti G, Nanni P, Oh Y, Picci P, Scotlandi K. PMID: 16570284.
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    159. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 2006 Aug 01; 12(15):4662-70. Kobayashi N, Barnard RJ, Henning SM, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J, Gui D, Seeram NP, Popoviciu LM, Bagga D, Heber D, Glaspy JA, Aronson WJ. PMID: 16899616; PMCID: PMC3410648.
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    162. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006 May; 189(2):289-99. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. PMID: 16648296.
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    166. Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma. Clin Cancer Res. 2006 Jan 15; 12(2):653-61. Oh SH, Kim WY, Kim JH, Younes MN, El-Naggar AK, Myers JN, Kies M, Cohen P, Khuri F, Hong WK, Lee HY. PMID: 16428512.
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    179. Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells. Growth Horm IGF Res. 2004 Jun; 14(3):216-25. Shim ML, Levitt Katz LE, Davis J, Dotzler WC, Cohen P, Ferry RJ. PMID: 15125883; PMCID: PMC3315378.
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    180. Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood. 2004 Jul 01; 104(1):237-42. Ikezoe T, Tanosaki S, Krug U, Liu B, Cohen P, Taguchi H, Koeffler HP. PMID: 15026318.
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    181. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4531-6. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML. PMID: 15070752; PMCID: PMC384781.
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    182. The role of insulin-like growth factor I monitoring in growth hormone-treated children. Horm Res. 2004; 62 Suppl 1:59-65. Park P, Cohen P. PMID: 15761234.
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    183. Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem. 2004 Jan 02; 279(1):469-76. Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P. PMID: 14576164.
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    184. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):13042-7. Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, Nishimoto I, Cohen P. PMID: 14561895; PMCID: PMC240741.
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    185. A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis. 2004 Jan; 25(1):47-59. Mikheev AM, Mikheeva SA, Liu B, Cohen P, Zarbl H. PMID: 14555616.
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    186. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr. 2003 Oct; 143(4):415-21. Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P, Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. PMID: 14571209.
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    187. Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. J Clin Endocrinol Metab. 2003 Jul; 88(7):3354-9. Wetterau LA, Francis MJ, Ma L, Cohen P. PMID: 12843187.
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    188. Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clin Cancer Res. 2003 Jul; 9(7):2734-43. Ngo TH, Barnard RJ, Cohen P, Freedland S, Tran C, deGregorio F, Elshimali YI, Heber D, Aronson WJ. PMID: 12855654.
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    189. Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology. 2003 Jun; 144(6):2319-24. Ngo TH, Barnard RJ, Leung PS, Cohen P, Aronson WJ. PMID: 12746292.
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    190. Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int J Cancer. 2003 May 20; 105(1):14-9. Moore MG, Wetterau LA, Francis MJ, Peehl DM, Cohen P. PMID: 12672024.
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    191. Individualized growth hormone therapy in children: advances beyond weight-based dosing. J Pediatr Endocrinol Metab. 2003 May; 16 Suppl 3:625-30. Lee KW, Cohen P. PMID: 12795364.
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    192. Type Ialpha collagen is an IGFBP-3 binding protein. Growth Horm IGF Res. 2003 Apr-Jun; 13(2-3):89-97. Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P. PMID: 12735930.
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    193. Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. J Clin Endocrinol Metab. 2003 Feb; 88(2):900-7. Franklin SL, Ferry RJ, Cohen P. PMID: 12574231; PMCID: PMC3314536.
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    194. Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy. Horm Res. 2003; 60 Suppl 3:115-23. Ali O, Cohen P. PMID: 14671408.
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    195. Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control. 2002 Dec; 13(10):929-35. Ngo TH, Barnard RJ, Tymchuk CN, Cohen P, Aronson WJ. PMID: 12588089.
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    196. Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis. J Clin Endocrinol Metab. 2002 Oct; 87(10):4817-20. Moran A, Jacobs DR, Steinberger J, Cohen P, Hong CP, Prineas R, Sinaiko AR. PMID: 12364479.
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    197. Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children. Growth Horm IGF Res. 2002 Oct; 12(5):323-41. Tanaka T, Cohen P, Clayton PE, Laron Z, Hintz RL, Sizonenko PC. PMID: 12213187.
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    198. IGFs and IGFBPs: role in health and disease. Best Pract Res Clin Endocrinol Metab. 2002 Sep; 16(3):433-47. Monzavi R, Cohen P. PMID: 12464227.
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    199. Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res. 2002 Jun 15; 62(12):3530-7. Lee HY, Chun KH, Liu B, Wiehle SA, Cristiano RJ, Hong WK, Cohen P, Kurie JM. PMID: 12068000.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    200. Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell Growth Differ. 2002 Apr; 13(4):163-71. Rajah R, Lee KW, Cohen P. PMID: 11971816.
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    201. Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. J Clin Endocrinol Metab. 2002 Jan; 87(1):90-8. Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG, American Norditropin Clinical Trials Group. PMID: 11788629.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCTClinical Trials
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