Pinchas Cohen, MD

Title(s)Dean, USC Leonard C. Davis School of Gerontology
SchoolSchool of Gerontology
AddressGER 103
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1354
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    The University of Southern California and Buck Institute Nathan Shock Center
    NIH P30AG068345Sep 15, 2020 - May 31, 2025
    Role: Co-Principal Investigator
    Metformin-Regulated Mitochondrial Peptides and their Effects on Aging
    NIH R01AG069698Sep 15, 2020 - May 31, 2025
    Role: Principal Investigator
    Ethnic-specific Effects of Mitochondrial DNA Variants and Environmental Factors on Cognitive Functioning and Dementia
    NIH R01AG068405Aug 1, 2020 - Apr 30, 2025
    Role: Principal Investigator
    Ethnic-Specific Mitochondrial DNA Variations that Contribute to Dementia
    NIH R56AG062693Aug 15, 2019 - Jul 31, 2020
    Role: Principal Investigator
    Humanin is an AD resilience factor through its interaction with APOE4
    NIH RF1AG061834Sep 30, 2018 - Mar 31, 2023
    Role: Principal Investigator
    Role of GPR120 and Macrophages in Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer
    NIH R01CA231219Sep 17, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator
    Plasma Mitochondrial Peptide Assays as Biomarkers of Environmental Toxin Exposure
    NIH R01ES020812Sep 19, 2011 - Jun 30, 2016
    Role: Principal Investigator
    Humanin and Type 2 Diabetes
    NIH R21DK089447Sep 1, 2011 - Aug 31, 2013
    Role: Co-Principal Investigator
    Novel Mitochondrially Encoded Peptides and Their Role in Health and Disease
    NIH R01GM090311Sep 30, 2009 - Mar 31, 2016
    Role: Principal Investigator
    A family of novel mitochondrially-encoded peptides and their role in aging
    NIH R01AG034430Jul 15, 2009 - Jun 30, 2014
    Role: Principal Investigator
    The Role of IGF2 in Fetal Growth Restriction
    NIH R01HD047013Jun 1, 2004 - Mar 31, 2010
    Role: Principal Investigator
    IGF-I: A Nutrition-Regulated Target in Prostate Cancer
    NIH R01CA100938Jun 13, 2003 - May 31, 2008
    Role: Principal Investigator
    Genomic and Non-Genomic Effects of IGFBP-3 on Apoptosis
    NIH R01AG020954Sep 30, 2001 - Aug 31, 2006
    Role: Principal Investigator
    IGF AXIS IN ASTHMA
    NIH R01AI040203Apr 1, 1998 - Mar 31, 2004
    Role: Principal Investigator
    IGF AXIS ABNORMALITIES IN BPH
    NIH R01DK047591Sep 30, 1993 - Aug 31, 2002
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology. Aging Cell. 2024 Jul; 23(7):e14153. Miller B, Kim SJ, Cao K, Mehta HH, Thumaty N, Kumagai H, Iida T, McGill C, Pike CJ, Nurmakova K, Levine ZA, Sullivan PM, Yen K, Ertekin-Taner N, Atzmon G, Barzilai N, Cohen P. PMID: 38520065; PMCID: PMC11258485.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    2. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024 Feb 20; 15(1):1309. Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. PMID: 38378685; PMCID: PMC10879164.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    3. Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration. Am J Physiol Endocrinol Metab. 2024 Mar 01; 326(3):E207-E214. Kumagai H, Kim SJ, Miller B, Natsume T, Wan J, Kumagai ME, Ramirez R, Lee SH, Sato A, Mehta HH, Yen K, Cohen P. PMID: 38170165; PMCID: PMC11196098.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. A naturally occurring variant of SHLP2 is a protective factor in Parkinson's disease. Mol Psychiatry. 2024 02; 29(2):505-517. Kim SJ, Miller B, Hartel NG, Ramirez R, Braniff RG, Leelaprachakul N, Huang A, Wang Y, Arpawong TE, Crimmins EM, Wang P, Sun X, Liu C, Levy D, Yen K, Petzinger GM, Graham NA, Jakowec MW, Cohen P. PMID: 38167865; PMCID: PMC11116102.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    5. Effect of omega-3 fatty acid diet on prostate cancer progression and cholesterol efflux in tumor-associated macrophages-dependence on GPR120. Prostate Cancer Prostatic Dis. 2024 Dec; 27(4):700-708. Liang P, Henning SM, Grogan T, Elashoff D, Said J, Cohen P, Aronson WJ. PMID: 37872251; PMCID: PMC11035487.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Correction: Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 Apr; 28(4):1827. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative. PMID: 36658336.
      View in: PubMed   Mentions:    Fields:    
    7. Novel Insights into Mitochondrial DNA: Mitochondrial Microproteins and mtDNA Variants Modulate Athletic Performance and Age-Related Diseases. Genes (Basel). 2023 01 21; 14(2). Kumagai H, Miller B, Kim SJ, Leelaprachakul N, Kikuchi N, Yen K, Cohen P. PMID: 36833212; PMCID: PMC9956216.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. Florida-California Cancer Research, Education and Engagement (CaRE2) Health Equity Center: Structure, Innovations, and Initial Outcomes. Cancer Control. 2023 Jan-Dec; 30:10732748231197878. Reams RR, Odedina FT, Carpten JD, Redda K, Stern MC, Krieger JL, Aparicio J, Hensel B, Askins N, Abreu A, Adams A, Agyare E, Ali J, Allen JM, Aló R, Baezconde-Garbanati L, Brant J, Brown CP, Buxbaum SG, Cohen P, Cozen W, Ezenwa MO, Falzarano S, Fillingim RB, Flores-Rozas H, Fredenburg KM, George T, Han B, Huang Y, Hughes Halbert C, Kiros GE, Lamango NS, Lee JH, Lyon DE, Mitchell DA, Mochona B, Nieva JJ, Offringa IA, Okunieff P, Parker A, Rhie SK, Richey JM, Rogers SC, Salhia B, Schmittgen TD, Segal R, Setiawan VW, Smith U, Su LM, Suther S, Trevino J, Velazquez-Villarreal EI, Webb FJ, Wu AH, Yao Y, Wilkie DJ. PMID: 37703814; PMCID: PMC10501072.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. Cell Rep. 2022 09 27; 40(13):111417. Rangan P, Lobo F, Parrella E, Rochette N, Morselli M, Stephen TL, Cremonini AL, Tagliafico L, Persia A, Caffa I, Monacelli F, Odetti P, Bonfiglio T, Nencioni A, Pigliautile M, Boccardi V, Mecocci P, Pike CJ, Cohen P, LaDu MJ, Pellegrini M, Xia K, Tran K, Ann B, Chowdhury D, Longo VD. PMID: 36170815; PMCID: PMC9648488.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    10. Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE. Mol Psychiatry. 2023 04; 28(4):1813-1826. Miller B, Kim SJ, Mehta HH, Cao K, Kumagai H, Thumaty N, Leelaprachakul N, Braniff RG, Jiao H, Vaughan J, Diedrich J, Saghatelian A, Arpawong TE, Crimmins EM, Ertekin-Taner N, Tubi MA, Hare ET, Braskie MN, Décarie-Spain L, Kanoski SE, Grodstein F, Bennett DA, Zhao L, Toga AW, Wan J, Yen K, Cohen P, Alzheimer’s Disease Neuroimaging Initiative*. PMID: 36127429; PMCID: PMC10027624.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    11. Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities. Prostate. 2022 09; 82(13):1248-1257. Ramirez-Torres A, Reagan AL, Howard LE, Wiggins E, Vidal AC, Wan J, Miller B, Freedland SJ, Cohen P. PMID: 35789022; PMCID: PMC9388542.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    12. Effect of Humanin G (HNG) on inflammation in age-related macular degeneration (AMD). Aging (Albany NY). 2022 05 16; 14(10):4247-4269. Nashine S, Cohen P, Wan J, Kenney MC. PMID: 35576057; PMCID: PMC9186758.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Mitochondria-derived peptides in aging and healthspan. J Clin Invest. 2022 05 02; 132(9). Miller B, Kim SJ, Kumagai H, Yen K, Cohen P. PMID: 35499074; PMCID: PMC9057581.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    14. Bladder cancer cells shift rapidly and spontaneously to cisplatin-resistant oxidative phosphorylation that is trackable in real time. Sci Rep. 2022 04 01; 12(1):5518. Xu T, Junge JA, Delfarah A, Lu YT, Arnesano C, Iqbal M, Delijani K, Hsieh TC, Hodara E, Mehta HH, Cohen P, Graham NA, Fraser SE, Goldkorn A. PMID: 35365706; PMCID: PMC8976067.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    15. Effects of dietary omega-3 fatty acids on orthotopic prostate cancer progression, tumor associated macrophages, angiogenesis and T-cell activation-dependence on GPR120. Prostate Cancer Prostatic Dis. 2022 09; 25(3):539-546. Liang P, Henning SM, Grogan T, Elashoff D, Ye H, Cohen P, Aronson WJ. PMID: 35075215; PMCID: PMC9308823.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    16. The MOTS-c K14Q polymorphism in the mtDNA is associated with muscle fiber composition and muscular performance. Biochim Biophys Acta Gen Subj. 2022 Feb; 1866(2):130048. Kumagai H, Natsume T, Kim SJ, Tobina T, Miyamoto-Mikami E, Shiose K, Ichinoseki-Sekine N, Kakigi R, Tsuzuki T, Miller B, Yen K, Murakami H, Miyachi M, Zempo H, Dobashi S, Machida S, Kobayashi H, Naito H, Cohen P, Fuku N. PMID: 34728329; PMCID: PMC8741734.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Humanin-induced autophagy plays important roles in skeletal muscle function and lifespan extension. Biochim Biophys Acta Gen Subj. 2022 01; 1866(1):130017. Kim SJ, Devgan A, Miller B, Lee SM, Kumagai H, Wilson KA, Wassef G, Wong R, Mehta HH, Cohen P, Yen K. PMID: 34624450; PMCID: PMC8595716.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    18. Extending human healthspan and longevity: a symposium report. Ann N Y Acad Sci. 2022 01; 1507(1):70-83. DeVito LM, Barzilai N, Cuervo AM, Niedernhofer LJ, Milman S, Levine M, Promislow D, Ferrucci L, Kuchel GA, Mannick J, Justice J, Gonzales MM, Kirkland JL, Cohen P, Campisi J. PMID: 34498278; PMCID: PMC10231756.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    19. Plasma mitochondrial derived peptides MOTS-c and SHLP2 positively associate with android and liver fat in people without diabetes. Biochim Biophys Acta Gen Subj. 2021 11; 1865(11):129991. Sequeira IR, Woodhead JST, Chan A, D'Souza RF, Wan J, Hollingsworth KG, Plank LD, Cohen P, Poppitt SD, Merry TL. PMID: 34419510.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    20. Effect of aerobic and resistance exercise on the mitochondrial peptide MOTS-c in Hispanic and Non-Hispanic White breast cancer survivors. Sci Rep. 2021 08 19; 11(1):16916. Dieli-Conwright CM, Sami N, Norris MK, Wan J, Kumagai H, Kim SJ, Cohen P. PMID: 34413391; PMCID: PMC8376922.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    21. Acute endurance exercise stimulates circulating levels of mitochondrial-derived peptides in humans. J Appl Physiol (1985). 2021 09 01; 131(3):1035-1042. von Walden F, Fernandez-Gonzalo R, Norrbom J, Emanuelsson EB, Figueiredo VC, Gidlund EK, Norrbrand L, Liu C, Sandström P, Hansson B, Wan J, Cohen P, Alkner B. PMID: 34351816.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    22. The IL-27 component EBI-3 and its receptor subunit IL-27Rα are essential for the cytoprotective action of humanin on male germ cells†. Biol Reprod. 2021 03 11; 104(3):717-730. Jia Y, Swerdloff RS, Lue Y, Dai-Ju J, Surampudi P, Cohen P, Wang C. PMID: 33330922; PMCID: PMC8527998.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    23. MOTS-c reduces myostatin and muscle atrophy signaling. Am J Physiol Endocrinol Metab. 2021 04 01; 320(4):E680-E690. Kumagai H, Coelho AR, Wan J, Mehta HH, Yen K, Huang A, Zempo H, Fuku N, Maeda S, Oliveira PJ, Cohen P, Kim SJ. PMID: 33554779; PMCID: PMC8238132.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    24. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nat Commun. 2021 01 20; 12(1):470. Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, Cameron-Smith D, Lu R, Cohen P, Graham NA, Benayoun BA, Merry TL, Lee C. PMID: 33473109; PMCID: PMC7817689.
      View in: PubMed   Mentions: 70     Fields:    Translation:HumansAnimalsCells
    25. A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c. Aging (Albany NY). 2021 01 19; 13(2):1692-1717. Zempo H, Kim SJ, Fuku N, Nishida Y, Higaki Y, Wan J, Yen K, Miller B, Vicinanza R, Miyamoto-Mikami E, Kumagai H, Naito H, Xiao J, Mehta HH, Lee C, Hara M, Patel YM, Setiawan VW, Moore TM, Hevener AL, Sutoh Y, Shimizu A, Kojima K, Kinoshita K, Arai Y, Hirose N, Maeda S, Tanaka K, Cohen P. PMID: 33468709; PMCID: PMC7880332.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCells
    26. Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples. Sci Rep. 2021 01 08; 11(1):3. Miller B, Silverstein A, Flores M, Cao K, Kumagai H, Mehta HH, Yen K, Kim SJ, Cohen P. PMID: 33420163; PMCID: PMC7794290.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    27. Nuclear-Encoded lncRNA MALAT1 Epigenetically Controls Metabolic Reprogramming in HCC Cells through the Mitophagy Pathway. Mol Ther Nucleic Acids. 2021 Mar 05; 23:264-276. Zhao Y, Zhou L, Li H, Sun T, Wen X, Li X, Meng Y, Li Y, Liu M, Liu S, Kim SJ, Xiao J, Li L, Zhang S, Li W, Cohen P, Hoffman AR, Hu JF, Cui J. PMID: 33425485; PMCID: PMC7773746.
      View in: PubMed   Mentions: 58  
    28. Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system. Transl Med Aging. 2020; 4:132-140. Silverstein AR, Flores MK, Miller B, Kim SJ, Yen K, Mehta HH, Cohen P. PMID: 32844137; PMCID: PMC7441040.
      View in: PubMed   Mentions:
    29. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    30. A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population. Transl Vis Sci Technol. 2020 05; 9(6):25. Miller B, Torres M, Jiang X, McKean-Cowdin R, Nousome D, Kim SJ, Mehta HH, Yen K, Cohen P, Varma R. PMID: 32821522; PMCID: PMC7408807.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    31. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp Cell Res. 2020 08 15; 393(2):112056. Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, Yen K, Cohen P. PMID: 32387288; PMCID: PMC7778388.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    32. High-intensity interval exercise increases humanin, a mitochondrial encoded peptide, in the plasma and muscle of men. J Appl Physiol (1985). 2020 05 01; 128(5):1346-1354. Woodhead JST, D'Souza RF, Hedges CP, Wan J, Berridge MV, Cameron-Smith D, Cohen P, Hickey AJR, Mitchell CJ, Merry TL. PMID: 32271093; PMCID: PMC7717117.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    33. Increased expression of the mitochondrial derived peptide, MOTS-c, in skeletal muscle of healthy aging men is associated with myofiber composition. Aging (Albany NY). 2020 03 17; 12(6):5244-5258. D'Souza RF, Woodhead JST, Hedges CP, Zeng N, Wan J, Kumagai H, Lee C, Cohen P, Cameron-Smith D, Mitchell CJ, Merry TL. PMID: 32182209; PMCID: PMC7138593.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    34. Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective. Horm Res Paediatr. 2019; 92(1):1-14. Collett-Solberg PF, Ambler G, Backeljauw PF, Bidlingmaier M, Biller BMK, Boguszewski MCS, Cheung PT, Choong CSY, Cohen LE, Cohen P, Dauber A, Deal CL, Gong C, Hasegawa Y, Hoffman AR, Hofman PL, Horikawa R, Jorge AAL, Juul A, Kamenický P, Khadilkar V, Kopchick JJ, Kriström B, Lopes MLA, Luo X, Miller BS, Misra M, Netchine I, Radovick S, Ranke MB, Rogol AD, Rosenfeld RG, Saenger P, Wit JM, Woelfle J. PMID: 31514194; PMCID: PMC6979443.
      View in: PubMed   Mentions: 110     Fields:    Translation:Humans
    35. Effect of dietary omega-3 fatty acids on castrate-resistant prostate cancer and tumor-associated macrophages. Prostate Cancer Prostatic Dis. 2020 03; 23(1):127-135. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 31439889; PMCID: PMC7031053.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    36. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 07; 7(13):e14171. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. PMID: 31293078; PMCID: PMC6640593.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    37. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 06 06; 15(6):88. Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. PMID: 31172328; PMCID: PMC6554247.
      View in: PubMed   Mentions: 23     Fields:    Translation:Animals
    38. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. PMID: 30980914; PMCID: PMC6506186.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    39. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 04 03; 8(4). Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. PMID: 30987182; PMCID: PMC6523867.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    40. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 04 03; 9(1):5546. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. PMID: 30944385; PMCID: PMC6447602.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    41. MOTS-c: an equal opportunity insulin sensitizer. J Mol Med (Berl). 2019 04; 97(4):487-490. Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. PMID: 30788534; PMCID: PMC6462348.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    42. Humanin is a novel regulator of Hedgehog signaling and prevents glucocorticoid-induced bone growth impairment. FASEB J. 2019 04; 33(4):4962-4974. Zaman F, Zhao Y, Celvin B, Mehta HH, Wan J, Chrysis D, Ohlsson C, Fadeel B, Cohen P, Sävendahl L. PMID: 30657335; PMCID: PMC6988867.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    43. Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer. J Natl Cancer Inst. 2019 01 01; 111(1):52-59. Liang P, Henning SM, Guan J, Grogan T, Elashoff D, Olefsky JM, Cohen P, Aronson WJ. PMID: 30202902; PMCID: PMC6335116.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    44. Growth hormone therapy in children; research and practice - A review. Growth Horm IGF Res. 2019 02; 44:20-32. Collett-Solberg PF, Jorge AAL, Boguszewski MCS, Miller BS, Choong CSY, Cohen P, Hoffman AR, Luo X, Radovick S, Saenger P. PMID: 30605792.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    45. Mitochondrial biology and prostate cancer ethnic disparity. Carcinogenesis. 2018 12 13; 39(11):1311-1319. Xiao J, Cohen P, Stern MC, Odedina F, Carpten J, Reams R. PMID: 30304372; PMCID: PMC6292412.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    46. Characterizing the protective effects of SHLP2, a mitochondrial-derived peptide, in macular degeneration. Sci Rep. 2018 10 11; 8(1):15175. Nashine S, Cohen P, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 30310092; PMCID: PMC6182005.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    47. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansAnimalsCells
    48. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1127-H1136. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. PMID: 30004252; PMCID: PMC6415743.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    49. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice. Nat Commun. 2018 06 19; 9(1):2394. Mao K, Quipildor GF, Tabrizian T, Novaj A, Guan F, Walters RO, Delahaye F, Hubbard GB, Ikeno Y, Ejima K, Li P, Allison DB, Salimi-Moosavi H, Beltran PJ, Cohen P, Barzilai N, Huffman DM. PMID: 29921922; PMCID: PMC6008442.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    50. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018 Jun 10; 10(6):1239-1256. Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P. PMID: 29886458; PMCID: PMC6046248.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    51. The Oxygen Paradox, the French Paradox, and age-related diseases. Geroscience. 2017 12; 39(5-6):499-550. Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA. PMID: 29270905; PMCID: PMC5745211.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    52. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int J Cardiol. 2018 03 01; 254:23-27. Qin Q, Delrio S, Wan J, Jay Widmer R, Cohen P, Lerman LO, Lerman A. PMID: 29242099.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    53. Phase II prospective randomized trial of weight loss prior to radical prostatectomy. Prostate Cancer Prostatic Dis. 2018 06; 21(2):212-220. Henning SM, Galet C, Gollapudi K, Byrd JB, Liang P, Li Z, Grogan T, Elashoff D, Magyar CE, Said J, Cohen P, Aronson WJ. PMID: 29203893; PMCID: PMC5986584.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCTClinical Trials
    54. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. J Vis Exp. 2017 09 25; (127). Kim SJ, Xiao J, Cohen P, Yen K. PMID: 28994791; PMCID: PMC5752322.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    55. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep. 2017 08 10; 7(1):7802. Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. PMID: 28798389; PMCID: PMC5552803.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCells
    56. Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk. Oncotarget. 2017 Nov 07; 8(55):94900-94909. Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ. PMID: 29212276; PMCID: PMC5706922.
      View in: PubMed   Mentions: 24     Fields:    
    57. Feeling misguided: a comment on the US guidelines on growth hormone and insulin-like growth factor-I treatment in children and adolescents. Curr Opin Pediatr. 2017 08; 29(4):472-474. Saenger P, Cohen P. PMID: 28604412.
      View in: PubMed   Mentions: Translation:Humans
    58. Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis. 2017 07 20; 8(7):e2951. Nashine S, Cohen P, Chwa M, Lu S, Nesburn AB, Kuppermann BD, Kenney MC. PMID: 28726777; PMCID: PMC5550888.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCellsCTClinical Trials
    59. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 11 01; 595(21):6613-6621. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. PMID: 28574175; PMCID: PMC5663826.
      View in: PubMed   Mentions: 75     Fields:    Translation:HumansAnimalsCells
    60. The GH receptor exon 3 deletion is a marker of male-specific exceptional longevity associated with increased GH sensitivity and taller stature. Sci Adv. 2017 06; 3(6):e1602025. Ben-Avraham D, Govindaraju DR, Budagov T, Fradin D, Durda P, Liu B, Ott S, Gutman D, Sharvit L, Kaplan R, Bougnères P, Reiner A, Shuldiner AR, Cohen P, Barzilai N, Atzmon G. PMID: 28630896; PMCID: PMC5473676.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    61. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635; PMCID: PMC5722247.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    62. Mitochondrial DNA Hypomethylation Is a Biomarker Associated with Induced Senescence in Human Fetal Heart Mesenchymal Stem Cells. Stem Cells Int. 2017; 2017:1764549. Yu D, Du Z, Pian L, Li T, Wen X, Li W, Kim SJ, Xiao J, Cohen P, Cui J, Hoffman AR, Hu JF. PMID: 28484495; PMCID: PMC5397648.
      View in: PubMed   Mentions: 24  
    63. Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes. Cell. 2017 02 23; 168(5):775-788.e12. Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD. PMID: 28235195; PMCID: PMC5357144.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    64. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. PMID: 28202779; PMCID: PMC6816332.
      View in: PubMed   Mentions: 220     Fields:    Translation:Humans
    65. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    66. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. PLoS One. 2016; 11(10):e0165150. Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton DR. PMID: 27783653; PMCID: PMC5081188.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    67. Lower circulating insulin-like growth factor-I is associated with better cognition in females with exceptional longevity without compromise to muscle mass and function. Aging (Albany NY). 2016 10 14; 8(10):2414-2424. Perice L, Barzilai N, Verghese J, Weiss EF, Holtzer R, Cohen P, Milman S. PMID: 27744417; PMCID: PMC5115897.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    68. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. PMID: 27384491; PMCID: PMC5216912.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    69. Effect of Dietary Omega-3 Fatty Acids on Tumor-Associated Macrophages and Prostate Cancer Progression. Prostate. 2016 10; 76(14):1293-302. Liang P, Henning SM, Schokrpur S, Wu L, Doan N, Said J, Grogan T, Elashoff D, Cohen P, Aronson WJ. PMID: 27338236; PMCID: PMC5081258.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    70. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 06 14; 23(6):1093-1112. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. PMID: 27304509; PMCID: PMC4911707.
      View in: PubMed   Mentions: 236     Fields:    Translation:AnimalsCells
    71. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. PMID: 27282289; PMCID: PMC4901417.
      View in: PubMed   Mentions: 94     Fields:    Translation:Humans
    72. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 11; 100:182-187. Lee C, Kim KH, Cohen P. PMID: 27216708; PMCID: PMC5116416.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    73. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 04; 8(4):796-809. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. PMID: 27070352; PMCID: PMC4925829.
      View in: PubMed   Mentions: 126     Fields:    Translation:HumansAnimalsCells
    74. Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations. Eur J Endocrinol. 2016 Jun; 174(6):C1-8. Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K. PMID: 27009113; PMCID: PMC5081743.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    75. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. PMID: 26990160; PMCID: PMC4811181.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansCells
    76. Central insulin-like growth factor-1 (IGF-1) restores whole-body insulin action in a model of age-related insulin resistance and IGF-1 decline. Aging Cell. 2016 Feb; 15(1):181-6. Huffman DM, Farias Quipildor G, Mao K, Zhang X, Wan J, Apontes P, Cohen P, Barzilai N. PMID: 26534869; PMCID: PMC4717281.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    77. The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology. 2015 Dec; 156(12):4511-21. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C. PMID: 26384090; PMCID: PMC4655208.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    78. Status of long-acting-growth hormone preparations--2015. Growth Horm IGF Res. 2015 Oct; 25(5):201-6. Høybye C, Cohen P, Hoffman AR, Ross R, Biller BM, Christiansen JS, Growth Hormone Research Society. PMID: 26187188.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    79. Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production. Mol Cell Endocrinol. 2015 Sep 15; 413:96-100. Paharkova V, Alvarez G, Nakamura H, Cohen P, Lee KW. PMID: 26116236.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    80. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
      View in: PubMed   Mentions: 387     Fields:    Translation:HumansAnimals
    81. The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis. 2015 Apr; 20(4):551-61. Jia Y, Ohanyan A, Lue YH, Swerdloff RS, Liu PY, Cohen P, Wang C. PMID: 25666707; PMCID: PMC4351164.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    82. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. PMID: 25738459; PMCID: PMC4350682.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansAnimalsCells
    83. The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus. Can J Physiol Pharmacol. 2015 Apr; 93(4):239-43. Lytvyn Y, Wan J, Lai V, Cohen P, Cherney DZ. PMID: 25615723.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    84. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    85. IGF1R blockade with ganitumab results in systemic effects on the GH-IGF axis in mice. J Endocrinol. 2014 Apr; 221(1):145-55. Moody G, Beltran PJ, Mitchell P, Cajulis E, Chung YA, Hwang D, Kendall R, Radinsky R, Cohen P, Calzone FJ. PMID: 24492468; PMCID: PMC4160154.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    86. Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell. 2014 Aug; 13(4):769-71. Milman S, Atzmon G, Huffman DM, Wan J, Crandall JP, Cohen P, Barzilai N. PMID: 24618355; PMCID: PMC4116456.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    87. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
      View in: PubMed   Mentions: 390     Fields:    Translation:HumansAnimalsCells
    88. New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. J Natl Cancer Inst. 2014 Mar; 106(3):dju006. Cohen P. PMID: 24586106; PMCID: PMC3982780.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimals
    89. Dose-sparing and safety-enhancing effects of an IGF-I-based dosing regimen in short children treated with growth hormone in a 2-year randomized controlled trial: therapeutic and pharmacoeconomic considerations. Clin Endocrinol (Oxf). 2014 Jul; 81(1):71-6. Cohen P, Weng W, Rogol AD, Rosenfeld RG, Kappelgaard AM, Germak J. PMID: 24428305; PMCID: PMC4160145.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    90. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology. 2013 Oct; 154(10):3739-44. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P. PMID: 23836030; PMCID: PMC3776863.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    91. Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts. Int J Mol Sci. 2013 Jul 03; 14(7):13782-95. Galet C, Gray A, Said JW, Castor B, Wan J, Beltran PJ, Calzone FJ, Elashoff D, Cohen P, Aronson WJ. PMID: 23823800; PMCID: PMC3742217.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    92. Prepubertal children with growth hormone deficiency treated for four years with growth hormone experience dose-dependent increase in height, but not in the rate of puberty initiation. Horm Res Paediatr. 2013; 80(1):28-37. Rogol AD, Cohen P, Weng W, Kappelgaard AM, Germak JA. PMID: 23816571.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    93. Response of the insulin-like growth factor (IGF) system to IGF-IR inhibition and androgen deprivation in a neoadjuvant prostate cancer trial: effects of obesity and androgen deprivation. J Clin Endocrinol Metab. 2013 May; 98(5):E820-8. Dean JP, Sprenger CC, Wan J, Haugk K, Ellis WJ, Lin DW, Corman JM, Dalkin BL, Mostaghel E, Nelson PS, Cohen P, Montgomery B, Plymate SR. PMID: 23533230; PMCID: PMC4430583.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    94. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. PMID: 23362919; PMCID: PMC3982836.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    95. Efficacy of IGF-based growth hormone (GH) dosing in nonGH-deficient (nonGHD) short stature children with low IGF-I is not related to basal IGF-I levels. Clin Endocrinol (Oxf). 2013 Mar; 78(3):405-14. Cohen P, Rogol AD, Weng W, Kappelgaard AM, Rosenfeld RG, Germak J, American Norditropin Study Group. PMID: 22924571.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    96. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. Lee C, Yen K, Cohen P. PMID: 23402768; PMCID: PMC3641182.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    97. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. Yen K, Lee C, Mehta H, Cohen P. PMID: 23239898; PMCID: PMC3705736.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    98. Resveratrol worsens survival in SCID mice with prostate cancer xenografts in a cell-line specific manner, through paradoxical effects on oncogenic pathways. Prostate. 2013 May; 73(7):754-62. Klink JC, Tewari AK, Masko EM, Antonelli J, Febbo PG, Cohen P, Dewhirst MW, Pizzo SV, Freedland SJ. PMID: 23192356; PMCID: PMC3628095.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    99. Growth hormone receptor (GHR) exon 3 polymorphism status detection by dual-enzyme-linked immunosorbent assay (ELISA). J Clin Endocrinol Metab. 2013 Jan; 98(1):E77-81. Wan J, Atzmon G, Hwang D, Barzlai N, Kratzsch J, Cohen P. PMID: 23162096; PMCID: PMC3537082.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    100. IGFBP-3 nuclear localization predicts human prostate cancer recurrence. Horm Cancer. 2013 Feb; 4(1):12-23. Seligson DB, Yu H, Tze S, Said J, Pantuck AJ, Cohen P, Lee KW. PMID: 23011725; PMCID: PMC3541441.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    101. Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life Sci. 2012 Sep 04; 91(5-6):199-206. Zhang X, Urbieta-Caceres VH, Eirin A, Bell CC, Crane JA, Tang H, Jordan KL, Oh YK, Zhu XY, Korsmo MJ, Bachar AR, Cohen P, Lerman A, Lerman LO. PMID: 22820173; PMCID: PMC3703734.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    102. How useful are serum IGF-I measurements for managing GH replacement therapy in adults and children? Pituitary. 2012 Jun; 15(2):126-34. Pawlikowska-Haddal A, Cohen P, Cook DM. PMID: 21909971.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    103. Effect of a low-fat diet combined with IGF-1 receptor blockade on 22Rv1 prostate cancer xenografts. Mol Cancer Ther. 2012 Jul; 11(7):1539-46. Konijeti R, Koyama S, Gray A, Barnard RJ, Said JW, Castor B, Elashoff D, Wan J, Beltran PJ, Calzone FJ, Cohen P, Galet C, Aronson WJ. PMID: 22562985; PMCID: PMC3392522.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    104. Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. PLoS One. 2012; 7(2):e31065. Zacharias DG, Kim SG, Massat AE, Bachar AR, Oh YK, Herrmann J, Rodriguez-Porcel M, Cohen P, Lerman LO, Lerman A. PMID: 22328926; PMCID: PMC3273477.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    105. Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab. 2012 Jan; 97(1):68-72. Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM. PMID: 22174422.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansPHPublic Health
    106. Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res (Phila). 2011 Dec; 4(12):2062-71. Aronson WJ, Kobayashi N, Barnard RJ, Henning S, Huang M, Jardack PM, Liu B, Gray A, Wan J, Konijeti R, Freedland SJ, Castor B, Heber D, Elashoff D, Said J, Cohen P, Galet C. PMID: 22027686; PMCID: PMC3232341.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    107. Global Igfbp1 deletion does not affect prostate cancer development in a c-Myc transgenic mouse model. J Endocrinol. 2011 Dec; 211(3):297-304. Gray A, Aronson WJ, Barnard RJ, Mehta H, Wan J, Said J, Cohen P, Galet C. PMID: 21903863; PMCID: PMC3271951.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    108. Insulin-like growth factor (IGF)-I and IGF-II contribute differentially to the phenotype of pregnancy associated plasma protein-A knock-out mice. Growth Horm IGF Res. 2011 Oct; 21(5):243-7. Mason EJ, Grell JA, Wan J, Cohen P, Conover CA. PMID: 21802327; PMCID: PMC3171618.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    109. Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 2011 Nov; 219(1):65-73. Oh YK, Bachar AR, Zacharias DG, Kim SG, Wan J, Cobb LJ, Lerman LO, Cohen P, Lerman A. PMID: 21763658; PMCID: PMC3885346.
      View in: PubMed   Mentions: 59     Fields:    Translation:Animals
    110. IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res. 2011 Aug 01; 71(15):5154-63. Mehta HH, Gao Q, Galet C, Paharkova V, Wan J, Said J, Sohn JJ, Lawson G, Cohen P, Cobb LJ, Lee KW. PMID: 21697285; PMCID: PMC3148406.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    111. Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med. 2011 Feb 16; 3(70):70ra13. Guevara-Aguirre J, Balasubramanian P, Guevara-Aguirre M, Wei M, Madia F, Cheng CW, Hwang D, Martin-Montalvo A, Saavedra J, Ingles S, de Cabo R, Cohen P, Longo VD. PMID: 21325617; PMCID: PMC3357623.
      View in: PubMed   Mentions: 370     Fields:    Translation:HumansCells
    112. Endocrine actions of myostatin: systemic regulation of the IGF and IGF binding protein axis. Endocrinology. 2011 Jan; 152(1):172-80. Williams NG, Interlichia JP, Jackson MF, Hwang D, Cohen P, Rodgers BD. PMID: 21147879; PMCID: PMC3219050.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    113. Chemoprevention of prostate cancer with lycopene in the TRAMP model. Prostate. 2010 Oct 01; 70(14):1547-54. Konijeti R, Henning S, Moro A, Sheikh A, Elashoff D, Shapiro A, Ku M, Said JW, Heber D, Cohen P, Aronson WJ. PMID: 20687227; PMCID: PMC2930120.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    114. Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. Prostate. 2010 Jul 01; 70(10):1037-43. Buschemeyer WC, Klink JC, Mavropoulos JC, Poulton SH, Demark-Wahnefried W, Hursting SD, Cohen P, Hwang D, Johnson TL, Freedland SJ. PMID: 20166128.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    115. Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res. 2010 Nov 01; 88(2):360-6. Bachar AR, Scheffer L, Schroeder AS, Nakamura HK, Cobb LJ, Oh YK, Lerman LO, Pagano RE, Cohen P, Lerman A. PMID: 20562421; PMCID: PMC2952532.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansCells
    116. Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children. J Clin Endocrinol Metab. 2010 May; 95(5):2089-98. Cohen P, Germak J, Rogol AD, Weng W, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group. PMID: 20207829.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    117. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. PMID: 20145127; PMCID: PMC2836202.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    118. Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. J Urol. 2010 Jan; 183(1):345-50. Aronson WJ, Barnard RJ, Freedland SJ, Henning S, Elashoff D, Jardack PM, Cohen P, Heber D, Kobayashi N. PMID: 19914662; PMCID: PMC3089950.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    119. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. PMID: 20157582; PMCID: PMC2815756.
      View in: PubMed   Mentions: 177     Fields:    Translation:Humans
    120. Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology. 2010 Jan; 151(1):350-7. Lue Y, Swerdloff R, Liu Q, Mehta H, Hikim AS, Lee KW, Jia Y, Hwang D, Cobb LJ, Cohen P, Wang C. PMID: 19952275.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    121. Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem. 2010 Jan 15; 285(3):1726-32. Jia Y, Lee KW, Swerdloff R, Hwang D, Cobb LJ, Sinha Hikim A, Lue YH, Cohen P, Wang C. PMID: 19887447; PMCID: PMC2804330.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    122. Pomegranate extract induces apoptosis in human prostate cancer cells by modulation of the IGF-IGFBP axis. Growth Horm IGF Res. 2010 Feb; 20(1):55-62. Koyama S, Cobb LJ, Mehta HH, Seeram NP, Heber D, Pantuck AJ, Cohen P. PMID: 19853487; PMCID: PMC2815223.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    123. The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism. 2010 Mar; 59(3):343-9. Hoang PT, Park P, Cobb LJ, Paharkova-Vatchkova V, Hakimi M, Cohen P, Lee KW. PMID: 19800083; PMCID: PMC2932671.
      View in: PubMed   Mentions: 72     Fields:    Translation:AnimalsCells
    124. Humanin: a novel central regulator of peripheral insulin action. PLoS One. 2009 Jul 22; 4(7):e6334. Muzumdar RH, Huffman DM, Atzmon G, Buettner C, Cobb LJ, Fishman S, Budagov T, Cui L, Einstein FH, Poduval A, Hwang D, Barzilai N, Cohen P. PMID: 19623253; PMCID: PMC2709436.
      View in: PubMed   Mentions: 131     Fields:    Translation:Animals
    125. Enhancing the apoptotic potential of insulin-like growth factor-binding protein-3 in prostate cancer by modulation of CK2 phosphorylation. Mol Endocrinol. 2009 Oct; 23(10):1624-33. Cobb LJ, Mehta H, Cohen P. PMID: 19556345; PMCID: PMC2754899.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    126. The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila). 2009 Jun; 2(6):557-65. Mavropoulos JC, Buschemeyer WC, Tewari AK, Rokhfeld D, Pollak M, Zhao Y, Febbo PG, Cohen P, Hwang D, Devi G, Demark-Wahnefried W, Westman EC, Peterson BL, Pizzo SV, Freedland SJ. PMID: 19470786; PMCID: PMC3774034.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    127. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem. 2009 Jul 24; 284(30):19937-44. Fan Y, Menon RK, Cohen P, Hwang D, Clemens T, DiGirolamo DJ, Kopchick JJ, Le Roith D, Trucco M, Sperling MA. PMID: 19460757; PMCID: PMC2740419.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    128. Optimizing growth hormone dosing in children with idiopathic short stature. Horm Res. 2009 Jan; 71 Suppl 1:70-4. Keni J, Cohen P. PMID: 19153511.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    129. PAPA-1 Is a nuclear binding partner of IGFBP-2 and modulates its growth-promoting actions. Mol Endocrinol. 2009 Feb; 23(2):169-75. Miyako K, Cobb LJ, Francis M, Huang A, Peng B, Pintar JE, Ariga H, Cohen P. PMID: 19095771; PMCID: PMC2646620.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    130. Surprising new height regulating genes: beyond growth hormone and IGF-I. Pediatr Res. 2008 Nov; 64(5):461. Hernández MI, Cohen P. PMID: 18931612.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    131. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. PMID: 18952711; PMCID: PMC2653987.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    132. Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression. Cancer Res. 2008 May 01; 68(9):3342-9. Anzo M, Cobb LJ, Hwang DL, Mehta H, Said JW, Yakar S, LeRoith D, Cohen P. PMID: 18451161; PMCID: PMC2928555.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    133. Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model. Cancer Res. 2008 Apr 15; 68(8):3066-73. Kobayashi N, Barnard RJ, Said J, Hong-Gonzalez J, Corman DM, Ku M, Doan NB, Gui D, Elashoff D, Cohen P, Aronson WJ. PMID: 18413778; PMCID: PMC2902987.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    134. Statement 1: a serum insulin-like growth factor I (IGF-I) level should be part of the evaluation of children with short stature. Pediatr Endocrinol Rev. 2008 Apr; 5 Suppl 3:834-6. Cohen P. PMID: 18438325.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    135. Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3438-42. Suh Y, Atzmon G, Cho MO, Hwang D, Liu B, Leahy DJ, Barzilai N, Cohen P. PMID: 18316725; PMCID: PMC2265137.
      View in: PubMed   Mentions: 354     Fields:    Translation:HumansCells
    136. Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate. 2008 Jan 01; 68(1):11-9. Freedland SJ, Mavropoulos J, Wang A, Darshan M, Demark-Wahnefried W, Aronson WJ, Cohen P, Hwang D, Peterson B, Fields T, Pizzo SV, Isaacs WB. PMID: 17999389; PMCID: PMC3959866.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimalsCells
    137. Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res. 2007 Nov 15; 67(22):11083-91. Raina K, Blouin MJ, Singh RP, Majeed N, Deep G, Varghese L, Glodé LM, Greenberg NM, Hwang D, Cohen P, Pollak MN, Agarwal R. PMID: 18006855.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    138. The somatomedin hypothesis 2007: 50 years later. J Clin Endocrinol Metab. 2007 Dec; 92(12):4529-35. Kaplan SA, Cohen P. PMID: 17986643.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimals
    139. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. Eur J Cancer Prev. 2007 Oct; 16(5):415-21. Barnard RJ, Leung PS, Aronson WJ, Cohen P, Golding LA. PMID: 17923812.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    140. Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth Horm IGF Res. 2008 Feb; 18(1):65-74. Hwang DL, Lee PD, Cohen P. PMID: 17719253; PMCID: PMC2276237.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    141. Treatment perspectives in idiopathic short stature with a focus on IGF-I deficiency. Pediatr Endocrinol Rev. 2007 May; 4 Suppl 2:252-71. Rosenthal S, Cohen P, Clayton P, Backeljauw P, Bang P, Ten S. PMID: 17581497.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    142. Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3. Carcinogenesis. 2007 Aug; 28(8):1653-8. Lee KW, Cobb LJ, Paharkova-Vatchkova V, Liu B, Milbrandt J, Cohen P. PMID: 17434920.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    143. Insulin growth factor-based dosing of growth hormone therapy in children: a randomized, controlled study. J Clin Endocrinol Metab. 2007 Jul; 92(7):2480-6. Cohen P, Rogol AD, Howard CP, Bright GM, Kappelgaard AM, Rosenfeld RG, American Norditropin Study Group. PMID: 17356043.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    144. Insulin-like growth factor binding protein-3 induces insulin resistance in adipocytes in vitro and in rats in vivo. Pediatr Res. 2007 Feb; 61(2):159-64. Kim HS, Ali O, Shim M, Lee KW, Vuguin P, Muzumdar R, Barzilai N, Cohen P. PMID: 17237715.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    145. Growth hormone therapy improves bone mineral density in children with cerebral palsy: a preliminary pilot study. J Clin Endocrinol Metab. 2007 Mar; 92(3):932-7. Ali O, Shim M, Fowler E, Greenberg M, Perkins D, Oppenheim W, Cohen P. PMID: 17179200.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    146. Phosphorylation by DNA-dependent protein kinase is critical for apoptosis induction by insulin-like growth factor binding protein-3. Cancer Res. 2006 Nov 15; 66(22):10878-84. Cobb LJ, Liu B, Lee KW, Cohen P. PMID: 17108124.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    147. Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. Diabetes. 2006 Oct; 55(10):2788-96. Muzumdar RH, Ma X, Fishman S, Yang X, Atzmon G, Vuguin P, Einstein FH, Hwang D, Cohen P, Barzilai N. PMID: 17003344.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    148. Controversy in clinical endocrinology: problems with reclassification of insulin-like growth factor I production and action disorders. J Clin Endocrinol Metab. 2006 Nov; 91(11):4235-6. Cohen P. PMID: 16954153.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    149. Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. Int J Cancer. 2006 Sep 01; 119(5):1039-46. Benini S, Zuntini M, Manara MC, Cohen P, Nicoletti G, Nanni P, Oh Y, Picci P, Scotlandi K. PMID: 16570284.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    150. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 2006 Aug 01; 12(15):4662-70. Kobayashi N, Barnard RJ, Henning SM, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J, Gui D, Seeram NP, Popoviciu LM, Bagga D, Heber D, Glaspy JA, Aronson WJ. PMID: 16899616; PMCID: PMC3410648.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    151. Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis. J Cell Physiol. 2006 Aug; 208(2):373-85. Colón E, Strand ML, Carlsson-Skwirut C, Wahlgren A, Svechnikov KV, Cohen P, Söder O. PMID: 16619233.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    152. Advances in pediatric growth hormone therapy: IGF-I-based dosing. Indian Pediatr. 2006 Jul; 43(7):577-81. Pawlikowska-Haddal A, Cohen P. PMID: 16891676.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    153. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006 May; 189(2):289-99. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. PMID: 16648296.
      View in: PubMed   Mentions: 44     Fields:    Translation:AnimalsCells
    154. Insulin-like growth factor binding protein-3: insulin-like growth factor independence comes of age. Endocrinology. 2006 May; 147(5):2109-11. Cohen P. PMID: 16617154.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    155. Overview of the IGF-I system. Horm Res. 2006; 65 Suppl 1:3-8. Cohen P. PMID: 16508327.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    156. Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3. Endocrinology. 2006 May; 147(5):2138-46. Oufattole M, Lin SW, Liu B, Mascarenhas D, Cohen P, Rodgers BD. PMID: 16455777.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    157. Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma. Clin Cancer Res. 2006 Jan 15; 12(2):653-61. Oh SH, Kim WY, Kim JH, Younes MN, El-Naggar AK, Myers JN, Kies M, Cohen P, Khuri F, Hong WK, Lee HY. PMID: 16428512.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    158. Racial differences in prognostic value of adult height for biochemical progression following radical prostatectomy. Clin Cancer Res. 2005 Nov 01; 11(21):7735-42. Freedland SJ, Aronson WJ, Trock B, Cohen P, Kane CJ, Amling CL, Presti JC, Terris MK, Shared Equal Access Regional Cancer Hospital Database Study Group. PMID: 16278394.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    159. Control of aging and longevity by IGF-I signaling. Exp Gerontol. 2005 Nov; 40(11):867-72. Yang J, Anzo M, Cohen P. PMID: 16154307.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    160. The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab. 2005 Sep-Oct; 86(1-2):84-90. Randhawa R, Cohen P. PMID: 16165387.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
    161. Insulin-like growth factor I (IGF-I) measurements in growth hormone (GH) therapy of idiopathic short stature (ISS). Growth Horm IGF Res. 2005 Jul; 15 Suppl A:S13-20. Park P, Cohen P. PMID: 16039893.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    162. Combination therapy of insulin-like growth factor binding protein-3 and retinoid X receptor ligands synergize on prostate cancer cell apoptosis in vitro and in vivo. Clin Cancer Res. 2005 Jul 01; 11(13):4851-6. Liu B, Lee KW, Li H, Ma L, Lin GL, Chandraratna RA, Cohen P. PMID: 16000583.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    163. Pharmacodynamic considerations with recombinant human insulin-like growth factor-I in children. Horm Res. 2005; 63(5):220-7. Ferry RJ, Cohen P, Levitt Katz LE. PMID: 15886488; PMCID: PMC3102299.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    164. p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab. 2005 Jun; 90(6):3568-74. Grimberg A, Coleman CM, Burns TF, Himelstein BP, Koch CJ, Cohen P, El-Deiry WS. PMID: 15769996; PMCID: PMC4145590.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    165. Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J Biol Chem. 2005 Apr 29; 280(17):16942-8. Lee KW, Ma L, Yan X, Liu B, Zhang XK, Cohen P. PMID: 15731112.
      View in: PubMed   Mentions: 68     Fields:    Translation:AnimalsCells
    166. Overexpression of gly56/gly80/gly81-mutant insulin-like growth factor-binding protein-3 in transgenic mice. Endocrinology. 2005 Mar; 146(3):1523-31. Silha JV, Gui Y, Mishra S, Leckstrom A, Cohen P, Murphy LJ. PMID: 15550509.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    167. Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol. 2005 Mar; 20(3):255-60. Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC. PMID: 15549416.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    168. EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol. 2004 Aug; 24(16):7275-83. Prieur A, Tirode F, Cohen P, Delattre O. PMID: 15282325; PMCID: PMC479730.
      View in: PubMed   Mentions: 182     Fields:    Translation:HumansCells
    169. Is treatment with growth hormone effective in children with cerebral palsy? Dev Med Child Neurol. 2004 Aug; 46(8):569-71. Shim ML, Moshang T, Oppenheim WL, Cohen P. PMID: 15287249.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    170. Insulin-like growth factor binding protein-3 is a novel mediator of apoptosis in insulin-secreting cells. Growth Horm IGF Res. 2004 Jun; 14(3):216-25. Shim ML, Levitt Katz LE, Davis J, Dotzler WC, Cohen P, Ferry RJ. PMID: 15125883; PMCID: PMC3315378.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    171. Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells. Blood. 2004 Jul 01; 104(1):237-42. Ikezoe T, Tanosaki S, Krug U, Liu B, Cohen P, Taguchi H, Koeffler HP. PMID: 15026318.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    172. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4531-6. Licinio J, Caglayan S, Ozata M, Yildiz BO, de Miranda PB, O'Kirwan F, Whitby R, Liang L, Cohen P, Bhasin S, Krauss RM, Veldhuis JD, Wagner AJ, DePaoli AM, McCann SM, Wong ML. PMID: 15070752; PMCID: PMC384781.
      View in: PubMed   Mentions: 138     Fields:    Translation:Humans
    173. The role of insulin-like growth factor I monitoring in growth hormone-treated children. Horm Res. 2004; 62 Suppl 1:59-65. Park P, Cohen P. PMID: 15761234.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    174. Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem. 2004 Jan 02; 279(1):469-76. Lee KW, Liu B, Ma L, Li H, Bang P, Koeffler HP, Cohen P. PMID: 14576164.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    175. Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):13042-7. Ikonen M, Liu B, Hashimoto Y, Ma L, Lee KW, Niikura T, Nishimoto I, Cohen P. PMID: 14561895; PMCID: PMC240741.
      View in: PubMed   Mentions: 131     Fields:    Translation:HumansAnimalsCells
    176. A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis. 2004 Jan; 25(1):47-59. Mikheev AM, Mikheeva SA, Liu B, Cohen P, Zarbl H. PMID: 14555616.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    177. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr. 2003 Oct; 143(4):415-21. Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P, Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. PMID: 14571209.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    178. Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. J Clin Endocrinol Metab. 2003 Jul; 88(7):3354-9. Wetterau LA, Francis MJ, Ma L, Cohen P. PMID: 12843187.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    179. Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clin Cancer Res. 2003 Jul; 9(7):2734-43. Ngo TH, Barnard RJ, Cohen P, Freedland S, Tran C, deGregorio F, Elshimali YI, Heber D, Aronson WJ. PMID: 12855654.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    180. Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology. 2003 Jun; 144(6):2319-24. Ngo TH, Barnard RJ, Leung PS, Cohen P, Aronson WJ. PMID: 12746292.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    181. Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int J Cancer. 2003 May 20; 105(1):14-9. Moore MG, Wetterau LA, Francis MJ, Peehl DM, Cohen P. PMID: 12672024.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    182. Individualized growth hormone therapy in children: advances beyond weight-based dosing. J Pediatr Endocrinol Metab. 2003 May; 16 Suppl 3:625-30. Lee KW, Cohen P. PMID: 12795364.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    183. Type Ialpha collagen is an IGFBP-3 binding protein. Growth Horm IGF Res. 2003 Apr-Jun; 13(2-3):89-97. Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P. PMID: 12735930.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    184. Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. J Clin Endocrinol Metab. 2003 Feb; 88(2):900-7. Franklin SL, Ferry RJ, Cohen P. PMID: 12574231; PMCID: PMC3314536.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    185. Insulin-like growth factors and their binding proteins in children born small for gestational age: implication for growth hormone therapy. Horm Res. 2003; 60 Suppl 3:115-23. Ali O, Cohen P. PMID: 14671408.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    186. Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control. 2002 Dec; 13(10):929-35. Ngo TH, Barnard RJ, Tymchuk CN, Cohen P, Aronson WJ. PMID: 12588089.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    187. Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis. J Clin Endocrinol Metab. 2002 Oct; 87(10):4817-20. Moran A, Jacobs DR, Steinberger J, Cohen P, Hong CP, Prineas R, Sinaiko AR. PMID: 12364479.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    188. Diagnosis and management of growth hormone deficiency in childhood and adolescence--part 2: growth hormone treatment in growth hormone deficient children. Growth Horm IGF Res. 2002 Oct; 12(5):323-41. Tanaka T, Cohen P, Clayton PE, Laron Z, Hintz RL, Sizonenko PC. PMID: 12213187.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    189. IGFs and IGFBPs: role in health and disease. Best Pract Res Clin Endocrinol Metab. 2002 Sep; 16(3):433-47. Monzavi R, Cohen P. PMID: 12464227.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    190. Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res. 2002 Jun 15; 62(12):3530-7. Lee HY, Chun KH, Liu B, Wiehle SA, Cristiano RJ, Hong WK, Cohen P, Kurie JM. PMID: 12068000.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    191. Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell Growth Differ. 2002 Apr; 13(4):163-71. Rajah R, Lee KW, Cohen P. PMID: 11971816.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    192. Effects of dose and gender on the growth and growth factor response to GH in GH-deficient children: implications for efficacy and safety. J Clin Endocrinol Metab. 2002 Jan; 87(1):90-8. Cohen P, Bright GM, Rogol AD, Kappelgaard AM, Rosenfeld RG, American Norditropin Clinical Trials Group. PMID: 11788629.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCTClinical Trials
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