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    Kelvin Yen

    TitleResearch Assistant Professor
    SchoolSchool of Gerontology
    DepartmentGerontology
    AddressGER 103
    University Park Campus
    Los Angeles California 90089-0191
    Phone+1 213 740 1354
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      Collapse Overview
      Kelvin Yen, Ph.D., attended U.C. Berkeley as an undergraduate where he earned his degree in molecular and cell biology with an emphasis in neurobiology and minored in computer science. He subsequently earned his Ph.D. at Mount Sinai School of Medicine of New York University in Neuroscience in the lab of Dr. Charles Mobbs. Because aging is a nearly universal phenomenon, Dr. Yen is interested in conserved mechanisms to increase healthspan and lifespan such as dietary restriction, temperature manipulation, decreasing insulin/IGF signaling, and specific mitochondrial mutations. He uses worms, mice, and both fly and human cell culture in his research. He is currently studying the signaling pathway between the mitochondria, the cell, and the rest of the body.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. PMID: 27384491.
        View in: PubMed
      2. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 Apr; 8(4):796-809. PMID: 27070352.
        View in: PubMed
      3. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar 1; 57(3):1238-53. PMID: 26990160.
        View in: PubMed
      4. Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E277-86. PMID: 25561524.
        View in: PubMed
      5. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. PMID: 25040290.
        View in: PubMed
      6. Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. PMID: 23402768.
        View in: PubMed
      7. Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. PMID: 23239898.
        View in: PubMed
      8. Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012 Apr 15; 302(8):E987-91. PMID: 22318949.
        View in: PubMed
      9. Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One. 2011; 6(11):e27762. PMID: 22114686.
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      10. Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA. PDP-1 links the TGF-ß and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet. 2011 Apr; 7(4):e1001377. PMID: 21533078.
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      11. Yen K, Narasimhan SD, Tissenbaum HA. DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal. 2011 Feb 15; 14(4):623-34. PMID: 20673162.
        View in: PubMed
      12. Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One. 2010; 5(9). PMID: 20862331.
        View in: PubMed
      13. Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. A new DAF-16 isoform regulates longevity. Nature. 2010 Jul 22; 466(7305):498-502. PMID: 20613724.
        View in: PubMed
      14. Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 2009 Nov; 7(11):e1000245. PMID: 19924292.
        View in: PubMed
      15. Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Curr Biol. 2009 Aug 11; 19(15):R657-66. PMID: 19674551.
        View in: PubMed
      16. Yen K, Mobbs CV. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr). 2010 Mar; 32(1):39-49. PMID: 19662517.
        View in: PubMed
      17. Yen K, Patel HB, Lublin AL, Mobbs CV. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mech Ageing Dev. 2009 Mar; 130(3):173-8. PMID: 19059428.
        View in: PubMed
      18. Yen K, Steinsaltz D, Mobbs CV. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Exp Gerontol. 2008 Dec; 43(12):1044-51. PMID: 18832022.
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      19. Yen K, Mobbs CV. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Exp Gerontol. 2008 Dec; 43(12):1058-60. PMID: 18790043.
        View in: PubMed
      20. Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdiscip Top Gerontol. 2007; 35:39-68. PMID: 17063032.
        View in: PubMed
      21. Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite. 2007 Mar; 48(2):135-8. PMID: 17141367.
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      22. Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis. Physiol Behav. 2005 May 19; 85(1):3-23. PMID: 15924903.
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      23. Yen K, Mastitis JW, Mobbs CV. Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans. Exp Gerontol. 2004 Jun; 39(6):947-9. PMID: 15217699.
        View in: PubMed
      24. Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res. 2004 Jun; 29(6):1093-103. PMID: 15176466.
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