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Kelvin Yen

Title(s)Research Assistant Professor
Phone+1 213 821 5822
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    Kelvin Yen, Ph.D., attended U.C. Berkeley as an undergraduate where he earned his degree in molecular and cell biology with an emphasis in neurobiology and minored in computer science. He subsequently earned his Ph.D. at Mount Sinai School of Medicine of New York University in Neuroscience in the lab of Dr. Charles Mobbs. Because aging is a nearly universal phenomenon, Dr. Yen is interested in conserved mechanisms to increase healthspan and lifespan such as dietary restriction, temperature manipulation, decreasing insulin/IGF signaling, and specific mitochondrial mutations. He uses worms, mice, and both fly and human cell culture in his research. He is currently studying the signaling pathway between the mitochondria, the cell, and the rest of the body.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 Jul; 7(13):e14171. PMID: 31293078.
      View in: PubMed
    2. Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 Jun 06; 15(6):88. PMID: 31172328.
      View in: PubMed
    3. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. PMID: 30980914.
      View in: PubMed
    4. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 Apr 03; 9(1):5546. PMID: 30944385.
      View in: PubMed
    5. Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 Apr 03; 8(4). PMID: 30987182.
      View in: PubMed
    6. Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. MOTS-c: an equal opportunity insulin sensitizer. J Mol Med (Berl). 2019 Apr; 97(4):487-490. PMID: 30788534.
      View in: PubMed
    7. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 Sep 21; 8(1):14212. PMID: 30242290.
      View in: PubMed
    8. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 Nov 01; 315(5):H1127-H1136. PMID: 30004252.
      View in: PubMed
    9. Kim SJ, Xiao J, Cohen P, Yen K. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. J Vis Exp. 2017 09 25; (127). PMID: 28994791.
      View in: PubMed
    10. Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep. 2017 08 10; 7(1):7802. PMID: 28798389.
      View in: PubMed
    11. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 11 01; 595(21):6613-6621. PMID: 28574175.
      View in: PubMed
    12. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. PMID: 28591635.
      View in: PubMed
    13. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. PMID: 27384491.
      View in: PubMed
    14. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 04; 8(4):796-809. PMID: 27070352.
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    15. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. PMID: 26990160.
      View in: PubMed
    16. Bansal A, Zhu LJ, Yen K, Tissenbaum HA. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E277-86. PMID: 25561524.
      View in: PubMed
    17. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. PMID: 25040290.
      View in: PubMed
    18. Lee C, Yen K, Cohen P. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. PMID: 23402768.
      View in: PubMed
    19. Yen K, Lee C, Mehta H, Cohen P. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. PMID: 23239898.
      View in: PubMed
    20. Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012 Apr 15; 302(8):E987-91. PMID: 22318949.
      View in: PubMed
    21. Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One. 2011; 6(11):e27762. PMID: 22114686.
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    22. Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA. PDP-1 links the TGF-ß and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet. 2011 Apr; 7(4):e1001377. PMID: 21533078.
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    23. Yen K, Narasimhan SD, Tissenbaum HA. DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal. 2011 Feb 15; 14(4):623-34. PMID: 20673162.
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    24. Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One. 2010 Sep 16; 5(9). PMID: 20862331.
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    25. Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. A new DAF-16 isoform regulates longevity. Nature. 2010 Jul 22; 466(7305):498-502. PMID: 20613724.
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    26. Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 2009 Nov; 7(11):e1000245. PMID: 19924292.
      View in: PubMed
    27. Narasimhan SD, Yen K, Tissenbaum HA. Converging pathways in lifespan regulation. Curr Biol. 2009 Aug 11; 19(15):R657-66. PMID: 19674551.
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    28. Yen K, Mobbs CV. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr). 2010 Mar; 32(1):39-49. PMID: 19662517.
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    29. Yen K, Patel HB, Lublin AL, Mobbs CV. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mech Ageing Dev. 2009 Mar; 130(3):173-8. PMID: 19059428.
      View in: PubMed
    30. Yen K, Steinsaltz D, Mobbs CV. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Exp Gerontol. 2008 Dec; 43(12):1044-51. PMID: 18832022.
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    31. Yen K, Mobbs CV. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Exp Gerontol. 2008 Dec; 43(12):1058-60. PMID: 18790043.
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    32. Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdiscip Top Gerontol. 2007; 35:39-68. PMID: 17063032.
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    33. Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite. 2007 Mar; 48(2):135-8. PMID: 17141367.
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    34. Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis. Physiol Behav. 2005 May 19; 85(1):3-23. PMID: 15924903.
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    35. Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res. 2004 Jun; 29(6):1093-103. PMID: 15176466.
      View in: PubMed
    36. Yen K, Mastitis JW, Mobbs CV. Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans. Exp Gerontol. 2004 Jun; 39(6):947-9. PMID: 15217699.
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