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Kelvin Yen

Title(s)Research Assistant Professor
Address3715 McClintock Avenue, GER B13
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 821 5822
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    Kelvin Yen, Ph.D., attended U.C. Berkeley as an undergraduate where he earned his degree in molecular and cell biology with an emphasis in neurobiology and minored in computer science. He subsequently earned his Ph.D. at Mount Sinai School of Medicine of New York University in Neuroscience in the lab of Dr. Charles Mobbs. Because aging is a nearly universal phenomenon, Dr. Yen is interested in conserved mechanisms to increase healthspan and lifespan such as dietary restriction, temperature manipulation, decreasing insulin/IGF signaling, and specific mitochondrial mutations. He uses worms, mice, and both fly and human cell culture in his research. He is currently studying the signaling pathway between the mitochondria, the cell, and the rest of the body.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mito-Omics and immune function: Applying novel mitochondrial omic techniques to the context of the aging immune system. Transl Med Aging. 2020; 4:132-140. Silverstein AR, Flores MK, Miller B, Kim SJ, Yen K, Mehta HH, Cohen P. PMID: 32844137.
      View in: PubMed   Mentions:
    2. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 Jun 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074.
      View in: PubMed   Mentions:    Fields:    
    3. A Mitochondrial Genome-Wide Association Study of Cataract in a Latino Population. Transl Vis Sci Technol. 2020 May; 9(6):25. Miller B, Torres M, Jiang X, McKean-Cowdin R, Nousome D, Kim SJ, Mehta HH, Yen K, Cohen P, Varma R. PMID: 32821522.
      View in: PubMed   Mentions:
    4. Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications. Exp Cell Res. 2020 May 05; 112056. Miller B, Kim SJ, Kumagai H, Mehta HH, Xiang W, Liu J, Yen K, Cohen P. PMID: 32387288.
      View in: PubMed   Mentions: 1     Fields:    
    5. The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiol Rep. 2019 07; 7(13):e14171. Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, Arpawong TE, Yen K, Cohen P. PMID: 31293078.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    6. Metabolomic profile of diet-induced obesity mice in response to humanin and small humanin-like peptide 2 treatment. Metabolomics. 2019 06 06; 15(6):88. Mehta HH, Xiao J, Ramirez R, Miller B, Kim SJ, Cohen P, Yen K. PMID: 31172328.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    7. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 05; 46:22-29. Breton CV, Song AY, Xiao J, Kim SJ, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. PMID: 30980914.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    8. Comparing the Utility of Mitochondrial and Nuclear DNA to Adjust for Genetic Ancestry in Association Studies. Cells. 2019 04 03; 8(4). Miller B, Arpawong TE, Jiao H, Kim SJ, Yen K, Mehta HH, Wan J, Carpten JC, Cohen P. PMID: 30987182.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    9. GRSF1 is an age-related regulator of senescence. Sci Rep. 2019 04 03; 9(1):5546. Kim SJ, Chun M, Wan J, Lee C, Yen K, Cohen P. PMID: 30944385.
      View in: PubMed   Mentions: 1     Fields:    
    10. MOTS-c: an equal opportunity insulin sensitizer. J Mol Med (Berl). 2019 04; 97(4):487-490. Kim SJ, Miller B, Kumagai H, Yen K, Cohen P. PMID: 30788534.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    11. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1127-H1136. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. PMID: 30004252.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment. J Vis Exp. 2017 09 25; (127). Kim SJ, Xiao J, Cohen P, Yen K. PMID: 28994791.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    14. The Mitochondrial-Derived Peptides, HumaninS14G and Small Humanin-like Peptide 2, Exhibit Chaperone-like Activity. Sci Rep. 2017 08 10; 7(1):7802. Okada AK, Teranishi K, Lobo F, Isas JM, Xiao J, Yen K, Cohen P, Langen R. PMID: 28798389.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    15. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 11 01; 595(21):6613-6621. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. PMID: 28574175.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    16. Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production. Cell Metab. 2017 Jun 06; 25(6):1320-1333.e5. Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR. PMID: 28591635.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    17. The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget. 2016 Jul 26; 7(30):46899-46912. Kim SJ, Guerrero N, Wassef G, Xiao J, Mehta HH, Cohen P, Yen K. PMID: 27384491.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    18. Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY). 2016 04; 8(4):796-809. Cobb LJ, Lee C, Xiao J, Yen K, Wong RG, Nakamura HK, Mehta HH, Gao Q, Ashur C, Huffman DM, Wan J, Muzumdar R, Barzilai N, Cohen P. PMID: 27070352.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    19. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci. 2016 Mar; 57(3):1238-53. Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. PMID: 26990160.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    20. Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):E277-86. Bansal A, Zhu LJ, Yen K, Tissenbaum HA. PMID: 25561524.
      View in: PubMed   Mentions: 76     Fields:    Translation:Animals
    21. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    22. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. Lee C, Yen K, Cohen P. PMID: 23402768.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
    23. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. Yen K, Lee C, Mehta H, Cohen P. PMID: 23239898.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimalsCells
    24. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012 Apr 15; 302(8):E987-91. Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. PMID: 22318949.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    25. FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. PLoS One. 2011; 6(11):e27762. Lublin A, Isoda F, Patel H, Yen K, Nguyen L, Hajje D, Schwartz M, Mobbs C. PMID: 22114686.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    26. PDP-1 links the TGF-ß and IIS pathways to regulate longevity, development, and metabolism. PLoS Genet. 2011 Apr; 7(4):e1001377. Narasimhan SD, Yen K, Bansal A, Kwon ES, Padmanabhan S, Tissenbaum HA. PMID: 21533078.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    27. DAF-16/Forkhead box O transcription factor: many paths to a single Fork(head) in the road. Antioxid Redox Signal. 2011 Feb 15; 14(4):623-34. Yen K, Narasimhan SD, Tissenbaum HA. PMID: 20673162.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    28. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One. 2010 Sep 16; 5(9). Yen K, Le TT, Bansal A, Narasimhan SD, Cheng JX, Tissenbaum HA. PMID: 20862331.
      View in: PubMed   Mentions: 69     Fields:    Translation:AnimalsCells
    29. A new DAF-16 isoform regulates longevity. Nature. 2010 Jul 22; 466(7305):498-502. Kwon ES, Narasimhan SD, Yen K, Tissenbaum HA. PMID: 20613724.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    30. Role of CBP and SATB-1 in aging, dietary restriction, and insulin-like signaling. PLoS Biol. 2009 Nov; 7(11):e1000245. Zhang M, Poplawski M, Yen K, Cheng H, Bloss E, Zhu X, Patel H, Mobbs CV. PMID: 19924292.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    31. Converging pathways in lifespan regulation. Curr Biol. 2009 Aug 11; 19(15):R657-66. Narasimhan SD, Yen K, Tissenbaum HA. PMID: 19674551.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    32. Evidence for only two independent pathways for decreasing senescence in Caenorhabditis elegans. Age (Dordr). 2010 Mar; 32(1):39-49. Yen K, Mobbs CV. PMID: 19662517.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. SOD isoforms play no role in lifespan in ad lib or dietary restricted conditions, but mutational inactivation of SOD-1 reduces life extension by cold. Mech Ageing Dev. 2009 Mar; 130(3):173-8. Yen K, Patel HB, Lublin AL, Mobbs CV. PMID: 19059428.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    34. Validated analysis of mortality rates demonstrates distinct genetic mechanisms that influence lifespan. Exp Gerontol. 2008 Dec; 43(12):1044-51. Yen K, Steinsaltz D, Mobbs CV. PMID: 18832022.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    35. Chemosensory and caloric mechanisms influence distinct components of mortality rate. Exp Gerontol. 2008 Dec; 43(12):1058-60. Yen K, Mobbs CV. PMID: 18790043.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    36. Secrets of the lac operon. Glucose hysteresis as a mechanism in dietary restriction, aging and disease. Interdiscip Top Gerontol. 2007; 35:39-68. Mobbs CV, Mastaitis JW, Zhang M, Isoda F, Cheng H, Yen K. PMID: 17063032.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    37. Low-carbohydrate diets cause obesity, low-carbohydrate diets reverse obesity: a metabolic mechanism resolving the paradox. Appetite. 2007 Mar; 48(2):135-8. Mobbs CV, Mastaitis J, Yen K, Schwartz J, Mohan V, Poplawski M, Isoda F. PMID: 17141367.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    38. Impaired glucose signaling as a cause of obesity and the metabolic syndrome: the glucoadipostatic hypothesis. Physiol Behav. 2005 May 19; 85(1):3-23. Mobbs CV, Isoda F, Makimura H, Mastaitis J, Mizuno T, Shu IW, Yen K, Yang XJ. PMID: 15924903.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    39. Mining microarrays for metabolic meaning: nutritional regulation of hypothalamic gene expression. Neurochem Res. 2004 Jun; 29(6):1093-103. Mobbs CV, Yen K, Mastaitis J, Nguyen H, Watson E, Wurmbach E, Sealfon SC, Brooks A, Salton SR. PMID: 15176466.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    40. Lifespan is not determined by metabolic rate: evidence from fishes and C. elegans. Exp Gerontol. 2004 Jun; 39(6):947-9. Yen K, Mastitis JW, Mobbs CV. PMID: 15217699.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
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