Sebastian Brandhorst

Title(s)Associate Professor Of Gerontology, Co-Director of the Aging Murine Phenotyping Core
SchoolSchool of Gerontology
AddressGER 313E
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 2034
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    Collapse Research 
    Collapse Research Activities and Funding
    Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH P01AG055369Feb 15, 2018 - Jan 31, 2023
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resist Updat. 2024 Dec 06; 101182. Brandhorst S, Longo VD. PMID: 39665873.
      View in: PubMed   Mentions:
    2. International consensus on fasting terminology. Cell Metab. 2024 Aug 06; 36(8):1779-1794.e4. Koppold DA, Breinlinger C, Hanslian E, Kessler C, Cramer H, Khokhar AR, Peterson CM, Tinsley G, Vernieri C, Bloomer RJ, Boschmann M, Bragazzi NL, Brandhorst S, Gabel K, Goldhamer AC, Grajower MM, Harvie M, Heilbronn L, Horne BD, Karras SN, Langhorst J, Lischka E, Madeo F, Mitchell SJ, Papagiannopoulos-Vatopaidinos IE, Papagiannopoulou M, Pijl H, Ravussin E, Ritzmann-Widderich M, Varady K, Adamidou L, Chihaoui M, de Cabo R, Hassanein M, Lessan N, Longo V, Manoogian ENC, Mattson MP, Muhlestein JB, Panda S, Papadopoulou SK, Rodopaios NE, Stange R, Michalsen A. PMID: 39059384; PMCID: PMC11504329.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Exploring juventology: unlocking the secrets of youthspan and longevity programs. Front Aging. 2024; 5:1379289. Brandhorst S, Longo VD. PMID: 38638872; PMCID: PMC11024265.
      View in: PubMed   Mentions:
    4. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nat Commun. 2024 Feb 20; 15(1):1309. Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. PMID: 38378685; PMCID: PMC10879164.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    5. The Effects of Dietary Interventions on Brain Aging and Neurological Diseases. Nutrients. 2022 Nov 30; 14(23). Lobo F, Haase J, Brandhorst S. PMID: 36501116; PMCID: PMC9740746.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    6. Breakfast keeps hunger in check. Cell Metab. 2022 10 04; 34(10):1420-1421. Brandhorst S, Longo VD. PMID: 36198286.
      View in: PubMed   Mentions: 1     Fields:    
    7. Diet composition influences the metabolic benefits of short cycles of very low caloric intake. Nat Commun. 2021 11 09; 12(1):6463. Diaz-Ruiz A, Rhinesmith T, Pomatto-Watson LCD, Price NL, Eshaghi F, Ehrlich MR, Moats JM, Carpenter M, Rudderow A, Brandhorst S, Mattison JA, Aon MA, Bernier M, Longo VD, de Cabo R. PMID: 34753921; PMCID: PMC8578605.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    8. Fasting-mimicking diet prevents high-fat diet effect on cardiometabolic risk and lifespan. Nat Metab. 2021 10; 3(10):1342-1356. Mishra A, Mirzaei H, Guidi N, Vinciguerra M, Mouton A, Linardic M, Rappa F, Barone R, Navarrete G, Wei M, Brandhorst S, Di Biase S, Morgan TE, Ram Kumar S, Conti PS, Pellegrini M, Bernier M, de Cabo R, Longo VD. PMID: 34650272.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    9. Time-Restricted Eating, Intermittent Fasting, and Fasting-Mimicking Diets in Weight Loss. Curr Obes Rep. 2021 Jun; 10(2):70-80. Fanti M, Mishra A, Longo VD, Brandhorst S. PMID: 33512641.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    10. Fasting and fasting-mimicking diets for chemotherapy augmentation. Geroscience. 2021 06; 43(3):1201-1216. Brandhorst S. PMID: 33410090; PMCID: PMC8190229.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    11. Periodic and Intermittent Fasting in Diabetes and Cardiovascular Disease. Curr Diab Rep. 2020 12 10; 20(12):83. Crupi AN, Haase J, Brandhorst S, Longo VD. PMID: 33301104.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    12. Author Correction: Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020 Dec; 588(7839):E33. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. PMID: 33273708.
      View in: PubMed   Mentions: 3     Fields:    
    13. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature. 2020 07; 583(7817):620-624. Caffa I, Spagnolo V, Vernieri C, Valdemarin F, Becherini P, Wei M, Brandhorst S, Zucal C, Driehuis E, Ferrando L, Piacente F, Tagliafico A, Cilli M, Mastracci L, Vellone VG, Piazza S, Cremonini AL, Gradaschi R, Mantero C, Passalacqua M, Ballestrero A, Zoppoli G, Cea M, Arrighi A, Odetti P, Monacelli F, Salvadori G, Cortellino S, Clevers H, De Braud F, Sukkar SG, Provenzani A, Longo VD, Nencioni A. PMID: 32669709; PMCID: PMC7881940.
      View in: PubMed   Mentions: 140     Fields:    Translation:HumansAnimalsCells
    14. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 06 23; 12(12):11185-11199. Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. PMID: 32575074; PMCID: PMC7343442.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    15. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nat Commun. 2020 05 11; 11(1):2332. Di Tano M, Raucci F, Vernieri C, Caffa I, Buono R, Fanti M, Brandhorst S, Curigliano G, Nencioni A, de Braud F, Longo VD. PMID: 32393788; PMCID: PMC7214421.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    16. Assessing Insulin and Glucose Tolerance in the Aging Mouse. Methods Mol Biol. 2020; 2144:125-129. Buono R, Brandhorst S. PMID: 32410030.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    17. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Adv Nutr. 2019 11 01; 10(Suppl_4):S340-S350. Brandhorst S, Longo VD. PMID: 31728501; PMCID: PMC6855936.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    18. Personalized Nutrition: Translating the Science of NutriGenomics Into Practice: Proceedings From the 2018 American College of Nutrition Meeting. J Am Coll Nutr. 2019 May-Jun; 38(4):287-301. Aruoma OI, Hausman-Cohen S, Pizano J, Schmidt MA, Minich DM, Joffe Y, Brandhorst S, Evans SJ, Brady DM. PMID: 31099726.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    19. Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease. Circ Res. 2019 03 15; 124(6):952-965. Brandhorst S, Longo VD. PMID: 30870119.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    20. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 03 05; 26(10):2704-2719.e6. Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. PMID: 30840892; PMCID: PMC6528490.
      View in: PubMed   Mentions: 107     Fields:    Translation:HumansAnimals
    21. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 09 21; 8(1):14212. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. PMID: 30242290; PMCID: PMC6154958.
      View in: PubMed   Mentions: 54     Fields:    Translation:HumansAnimalsCells
    22. Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1127-H1136. Qin Q, Mehta H, Yen K, Navarrete G, Brandhorst S, Wan J, Delrio S, Zhang X, Lerman LO, Cohen P, Lerman A. PMID: 30004252; PMCID: PMC6415743.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    23. Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 May; 15(5):e1002603. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28459830; PMCID: PMC5411024.
      View in: PubMed   Mentions: 1     Fields:    
    24. Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy. PLoS Biol. 2017 03; 15(3):e2001951. Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD. PMID: 28358805; PMCID: PMC5373519.
      View in: PubMed   Mentions: 34     Fields:    Translation:Animals
    25. Protective effects of short-term dietary restriction in surgical stress and chemotherapy. Ageing Res Rev. 2017 Oct; 39:68-77. Brandhorst S, Harputlugil E, Mitchell JR, Longo VD. PMID: 28216454; PMCID: PMC5722209.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    26. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Sci Transl Med. 2017 02 15; 9(377). Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. PMID: 28202779; PMCID: PMC6816332.
      View in: PubMed   Mentions: 217     Fields:    Translation:Humans
    27. Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice. Sci Rep. 2017 02 01; 7:40919. Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L. PMID: 28145503; PMCID: PMC5286507.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    28. Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity. Cancer Cell. 2016 07 11; 30(1):136-146. Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD. PMID: 27411588; PMCID: PMC5388544.
      View in: PubMed   Mentions: 176     Fields:    Translation:HumansAnimalsCells
    29. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer. 2016 06 10; 16:360. Dorff TB, Groshen S, Garcia A, Shah M, Tsao-Wei D, Pham H, Cheng CW, Brandhorst S, Cohen P, Wei M, Longo V, Quinn DI. PMID: 27282289; PMCID: PMC4901417.
      View in: PubMed   Mentions: 95     Fields:    Translation:Humans
    30. A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms. Cell Rep. 2016 06 07; 15(10):2136-2146. Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD. PMID: 27239035; PMCID: PMC4899145.
      View in: PubMed   Mentions: 201     Fields:    Translation:HumansAnimalsCells
    31. Fasting and Caloric Restriction in Cancer Prevention and Treatment. Recent Results Cancer Res. 2016; 207:241-66. Brandhorst S, Longo VD. PMID: 27557543; PMCID: PMC7476366.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    32. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 07; 22(1):86-99. Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. PMID: 26094889; PMCID: PMC4509734.
      View in: PubMed   Mentions: 389     Fields:    Translation:HumansAnimals
    33. Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells. Cancer Res. 2015 Mar 15; 75(6):1056-67. Shim HS, Wei M, Brandhorst S, Longo VD. PMID: 25614517; PMCID: PMC4359966.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    34. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. PMID: 24606898; PMCID: PMC3988204.
      View in: PubMed   Mentions: 391     Fields:    Translation:HumansAnimalsCells
    35. Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression. Exp Gerontol. 2013 Oct; 48(10):1120-8. Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD. PMID: 23454633; PMCID: PMC3762887.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    36. Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways. Cell Death Dis. 2012 Oct 11; 3:e401. Minois N, Carmona-Gutierrez D, Bauer MA, Rockenfeller P, Eisenberg T, Brandhorst S, Sigrist SJ, Kroemer G, Madeo F. PMID: 23059820; PMCID: PMC3481127.
      View in: PubMed   Mentions: 49     Fields:    Translation:Animals
    37. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603. Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. PMID: 22984531; PMCID: PMC3439413.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    38. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012 Mar 07; 4(124):124ra27. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. PMID: 22323820; PMCID: PMC3608686.
      View in: PubMed   Mentions: 300     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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