Changhan David Lee, PhD

Title(s)Associate Professor of Gerontology
SchoolSchool of Gerontology
AddressGER B12
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1396
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Regulation of Cellular Proliferation by Novel Mitochondrial-Encoded Tumor Suppressors
    NIH R01GM136837Sep 1, 2020 - May 31, 2024
    Role: Principal Investigator
    Novel Regulators of Aging Metabolism Encoded in the Mitochondrial Genome
    NIH R01AG052558Aug 1, 2016 - Apr 30, 2021
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016 11; 100:182-187. Lee C, Kim KH, Cohen P. PMID: 27216708; PMCID: PMC5116416.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. PMID: 25738459; PMCID: PMC4350682.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansAnimalsCells
    3. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. PMID: 25040290; PMCID: PMC4172517.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    4. Draft Genome Sequence of Pseudomonas aeruginosa SG17M, an Environmental Isolate Belonging to Clone C, Prevalent in Patients and Aquatic Habitats. Genome Announc. 2014 Mar 20; 2(2). Lee C, Peters V, Melefors O, Römling U. PMID: 24652978; PMCID: PMC3961725.
      View in: PubMed   Mentions: 3  
    5. Glyoxal detoxification in Escherichia coli K-12 by NADPH dependent aldo-keto reductases. J Microbiol. 2013 Aug; 51(4):527-30. Lee C, Kim I, Park C. PMID: 23990306.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    6. Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12. Mol Microbiol. 2013 Apr; 88(2):395-412. Lee C, Shin J, Park C. PMID: 23506073.
      View in: PubMed   Mentions: 23     Fields:    Translation:Cells
    7. Mutations upregulating the flhDC operon of Escherichia coli K-12. J Microbiol. 2013 Feb; 51(1):140-4. Lee C, Park C. PMID: 23456724.
      View in: PubMed   Mentions: 15     Fields:    Translation:Cells
    8. Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab. 2013 May; 24(5):222-8. Lee C, Yen K, Cohen P. PMID: 23402768; PMCID: PMC3641182.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    9. The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol. 2013 Feb; 50(1):R11-9. Yen K, Lee C, Mehta H, Cohen P. PMID: 23239898; PMCID: PMC3705736.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    10. Fasting enhances the response of glioma to chemo- and radiotherapy. PLoS One. 2012; 7(9):e44603. Safdie F, Brandhorst S, Wei M, Wang W, Lee C, Hwang S, Conti PS, Chen TC, Longo VD. PMID: 22984531; PMCID: PMC3439413.
      View in: PubMed   Mentions: 97     Fields:    Translation:AnimalsCells
    11. Development of a suicidal vector-cloning system based on butanal susceptibility due to an expression of YqhD aldehyde reductase. J Microbiol. 2012 Apr; 50(2):249-55. Lee C, Park C. PMID: 22538653.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    12. Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):114-22. Lee C, Raffaghello L, Longo VD. PMID: 22391012; PMCID: PMC3573885.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    13. Genomic rearrangements leading to overexpression of aldo-keto reductase YafB of Escherichia coli confer resistance to glyoxal. J Bacteriol. 2012 Apr; 194(8):1979-88. Kwon M, Lee J, Lee C, Park C. PMID: 22328670; PMCID: PMC3318463.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    14. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Sci Transl Med. 2012 Mar 07; 4(124):124ra27. Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Martin-Montalvo A, Pistoia V, Wei M, Hwang S, Merlino A, Emionite L, de Cabo R, Longo VD. PMID: 22323820; PMCID: PMC3608686.
      View in: PubMed   Mentions: 299     Fields:    Translation:HumansAnimalsCells
    15. Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12. J Bacteriol. 2010 Aug; 192(16):4205-14. Lee C, Kim I, Lee J, Lee KL, Min B, Park C. PMID: 20543070; PMCID: PMC2916428.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    16. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res. 2010 Feb 15; 70(4):1564-72. Lee C, Safdie FM, Raffaghello L, Wei M, Madia F, Parrella E, Hwang D, Cohen P, Bianchi G, Longo VD. PMID: 20145127; PMCID: PMC2836202.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    17. Fasting and cancer treatment in humans: A case series report. Aging (Albany NY). 2009 Dec 31; 1(12):988-1007. Safdie FM, Dorff T, Quinn D, Fontana L, Wei M, Lee C, Cohen P, Longo VD. PMID: 20157582; PMCID: PMC2815756.
      View in: PubMed   Mentions: 177     Fields:    Translation:Humans
    18. Surface growth on diluted lattices by a restricted solid-on-solid model. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug; 80(2 Pt 1):021134. Lee C, Lee SB. PMID: 19792104.
      View in: PubMed   Mentions:    Fields:    
    19. T-POP array identifies EcnR and PefI-SrgD as novel regulators of flagellar gene expression. J Bacteriol. 2009 Mar; 191(5):1498-508. Wozniak CE, Lee C, Hughes KT. PMID: 19114490; PMCID: PMC2648201.
      View in: PubMed   Mentions: 32     Fields:    Translation:Cells
    20. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8215-20. Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. PMID: 18378900; PMCID: PMC2448817.
      View in: PubMed   Mentions: 249     Fields:    Translation:HumansAnimalsCells
    21. Screening of genes related to methylglyoxal susceptibility. J Microbiol. 2007 Aug; 45(4):339-43. Kim I, Kim J, Min B, Lee C, Park C. PMID: 17846588.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    22. Genomic screening for regulatory genes using the T-POP transposon. Methods Enzymol. 2007; 421:159-67. Lee C, Wozniak C, Karlinsey JE, Hughes KT. PMID: 17352922.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    23. Depinning transition of the Mullins-Herring equation with an external driving force and quenched random disorder. Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Jan; 73(1 Pt 2):016140. Lee C, Kim JM. PMID: 16486249.
      View in: PubMed   Mentions:    Fields:    
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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