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Junxiang Wan, MD, PhD

TitleResearch Assistant Professor
InstitutionUniversity of Southern California
DepartmentGerontology
Address3715 McClintock Avenue, GER B1B
University Park Campus
Los Angeles CA 90089-0191
Phone+1 213 740 1398
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    Dr. Wan has extensive training in molecular biology, cell biology and immunology. She is an expert in the field of novel assay development, and has extensive experience in academic research work. Dr. Wan mastered novel ELISA assays for the entire murine IGF/IGFBP system and for human and murine humanin and have done lots of IGFs, IGFBPs and humanin assays with the other collaborators, and developed new assays for mitochondria small peptides (MDPs). She has directed core facilities at UCLA and USC, focusing on translation of assays and novel assay development.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P. Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans. Sci Rep. 2018 Sep 21; 8(1):14212. PMID: 30242290.
      View in: PubMed
    2. Kim SJ, Mehta HH, Wan J, Kuehnemann C, Chen J, Hu JF, Hoffman AR, Cohen P. Mitochondrial peptides modulate mitochondrial function during cellular senescence. Aging (Albany NY). 2018 Jun 10. PMID: 29886458.
      View in: PubMed
    3. Xiao J, Howard L, Wan J, Wiggins E, Vidal A, Cohen P, Freedland SJ. Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk. Oncotarget. 2017 Nov 07; 8(55):94900-94909. PMID: 29212276.
      View in: PubMed
    4. Kim SJ, Xiao J, Wan J, Cohen P, Yen K. Mitochondrially derived peptides as novel regulators of metabolism. J Physiol. 2017 Nov 01; 595(21):6613-6621. PMID: 28574175.
      View in: PubMed
    5. Lue Y, Swerdloff R, Wan J, Xiao J, French S, Atienza V, Canela V, Bruhn KW, Stone B, Jia Y, Cohen P, Wang C. The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology. 2015 Dec; 156(12):4511-21. PMID: 26384090; PMCID: PMC4655208 [Available on 12/01/16].
    6. Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, Cohen P. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015 Mar 03; 21(3):443-54. PMID: 25738459; PMCID: PMC4350682.
    7. Lee C, Wan J, Miyazaki B, Fang Y, Guevara-Aguirre J, Yen K, Longo V, Bartke A, Cohen P. IGF-I regulates the age-dependent signaling peptide humanin. Aging Cell. 2014 Oct; 13(5):958-61. PMID: 25040290; PMCID: PMC4172517.
    8. Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metab. 2014 Mar 04; 19(3):407-17. PMID: 24606898; PMCID: PMC3988204.
    9. Chin YP, Keni J, Wan J, Mehta H, Anene F, Jia Y, Lue YH, Swerdloff R, Cobb LJ, Wang C, Cohen P. Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology. 2013 Oct; 154(10):3739-44. PMID: 23836030; PMCID: PMC3776863.
    10. Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging Cell. 2013 Apr; 12(2):257-68. PMID: 23362919; PMCID: PMC3982836.