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Marc Vermulst

Title(s)Assistant Professor
Phone+1 213 821 2488
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the IGF-1/insulin signaling pathway to treat mtDNA disease
    NIH/NIGMS R01GM124532Aug 1, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Understanding the role of transcription errors in aging and disease
    NIH/NIA R01AG054641Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Non-genetic Mutations in Aging Organisms
    NIH/NIA R00AG041809Sep 15, 2013 - Jun 30, 2016
    Role: Principal Investigator
    Non-genetic Mutations in Aging Organisms
    NIH/NIA K99AG041809Aug 1, 2012 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019 Jul 22; 110675. PMID: 31344454.
      View in: PubMed
    2. Fritsch C, Gout JP, Vermulst M. Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms. J Vis Exp. 2018 09 13; (139). PMID: 30272673.
      View in: PubMed
    3. McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metab. 2019 Jan 08; 29(1):78-90.e5. PMID: 30174309.
      View in: PubMed
    4. Verheijen BM, Vermulst M, van Leeuwen FW. Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 06; 135(6):811-826. PMID: 29705908.
      View in: PubMed
    5. Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M. Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Rep. 2018 03 20; 22(12):3115-3125. PMID: 29562168.
      View in: PubMed
    6. Gout JF, Li W, Fritsch C, Li A, Haroon S, Singh L, Hua D, Fazelinia H, Smith Z, Seeholzer S, Thomas K, Lynch M, Vermulst M. The landscape of transcription errors in eukaryotic cells. Sci Adv. 2017 10; 3(10):e1701484. PMID: 29062891.
      View in: PubMed
    7. Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017; 12(2):e0171159. PMID: 28158260.
      View in: PubMed
    8. Haroon S, Vermulst M. Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 06; 38:68-74. PMID: 27235806.
      View in: PubMed
    9. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Oct 14; 6:8738. PMID: 26465398.
      View in: PubMed
    10. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Mosely AM, Thompson JW, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Aug 25; 6:8065. PMID: 26304740.
      View in: PubMed
    11. Ericson NG, Kulawiec M, Vermulst M, Sheahan K, O'Sullivan J, Salk JJ, Bielas JH. Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet. 2012; 8(6):e1002689. PMID: 22685414.
      View in: PubMed
    12. Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010 Apr 16; 141(2):280-9. PMID: 20403324.
      View in: PubMed
    13. Vermulst M, Wanagat J, Loeb LA. On mitochondria, mutations, and methodology. Cell Metab. 2009 Dec; 10(6):437. PMID: 19945399.
      View in: PubMed
    14. Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 2009 Jun 02; 119(21):2789-97. PMID: 19451351.
      View in: PubMed
    15. Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec; 46(4):263-8. PMID: 18948200.
      View in: PubMed
    16. Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr; 40(4):392-4. PMID: 18311139.
      View in: PubMed
    17. Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr; 39(4):540-3. PMID: 17334366.
      View in: PubMed
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