Marc Vermulst

Title(s)Assistant Professor of Gerontology
SchoolSchool of Gerontology
AddressGER 313F
University Park Campus
Los Angeles CA 90089
Phone+1 213 821 2488
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    Collapse Research 
    Collapse Research Activities and Funding
    Targeting the IGF-1/insulin signaling pathway to treat mtDNA disease
    NIH R01GM124532Aug 1, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Understanding the role of transcription errors in aging and disease
    NIH R01AG054641Mar 1, 2017 - Feb 28, 2022
    Role: Principal Investigator
    Non-genetic Mutations in Aging Organisms
    NIH R00AG041809Sep 15, 2013 - Jun 30, 2016
    Role: Principal Investigator
    Non-genetic Mutations in Aging Organisms
    NIH K99AG041809Aug 1, 2012 - Jun 30, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Transcript errors generate amyloid-like proteins in huwman cells. Nat Commun. 2024 Oct 07; 15(1):8676. Chung CS, Kou Y, Shemtov SJ, Verheijen BM, Flores I, Love K, Del Dosso A, Thorwald MA, Liu Y, Hicks D, Sun Y, Toney RG, Carrillo L, Nguyen MM, Biao H, Jin Y, Jauregui AM, Quiroz JD, Head E, Moore DL, Simpson S, Thomas KW, Coba MP, Li Z, Benayoun BA, Rosenthal JJC, Kennedy SR, Quadrato G, Gout JF, Chen L, Vermulst M. PMID: 39375347; PMCID: PMC11458900.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations. Nucleic Acids Res. 2024 Sep 09; 52(16):e76. Vermulst M, Paskvan SL, Chung CS, Franke K, Clegg N, Minot S, Madeoy J, Long AS, Gout JF, Bielas JH. PMID: 39149908; PMCID: PMC11381349.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    3. Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity. Environ Pollut. 2024 Sep 01; 356:124203. Dinep-Schneider O, Appiah E, Dapper A, Patterson S, Vermulst M, Gout JF. PMID: 38830529; PMCID: PMC11321929.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    4. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Apr 03. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38570396.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis. Acta Neuropathol Commun. 2024 02 21; 12(1):30. Verheijen BM, Chung C, Thompson B, Kim H, Nakahara A, Anink JJ, Mills JD, NYGC ALS Consortium, Lee JH, Aronica E, Oyanagi K, Kakita A, Gout JF, Vermulst M. PMID: 38383591; PMCID: PMC10882831.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    6. Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc Natl Acad Sci U S A. 2023 Dec 19; 120(51):e2306767120. Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. PMID: 38100415; PMCID: PMC10743375.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    7. Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging. bioRxiv. 2023 Nov 27. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38077060; PMCID: PMC10705228.
      View in: PubMed   Mentions:
    8. Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity. J Mol Biol. 2023 12 15; 435(24). Wang S, Kim K, Gelvez N, Chung C, Gout JF, Fixman B, Vermulst M, Chen XS. PMID: 38708190; PMCID: PMC11068304.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    9. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv. 2023 Apr 28. Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. PMID: 37162924; PMCID: PMC10168338.
      View in: PubMed   Mentions:
    10. Evolutionary conservation of the fidelity of transcription. Nat Commun. 2023 03 20; 14(1):1547. Chung C, Verheijen BM, Navapanich Z, McGann EG, Shemtov S, Lai GJ, Arora P, Towheed A, Haroon S, Holczbauer A, Chang S, Manojlovic Z, Simpson S, Thomas KW, Kaplan C, van Hasselt P, Timmers M, Erie D, Chen L, Gout JF, Vermulst M. PMID: 36941254; PMCID: PMC10027832.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. The fidelity of transcription in human cells. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2210038120. Chung C, Verheijen BM, Zhang X, Huang B, Coakley A, McGann E, Wade E, Dinep-Schneider O, LaGosh J, Anagnostou ME, Simpson S, Thomas K, Ernst M, Rattray A, Lynch M, Kashlev M, Benayoun BA, Li Z, Strathern J, Gout JF, Vermulst M. PMID: 36696440; PMCID: PMC9945944.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    12. Genome-wide surveillance of transcription errors in response to genotoxic stress. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. PMID: 33443141; PMCID: PMC7817157.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    13. Correction to: Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2020 09; 140(3):415. Verheijen BM, Vermulst M, van Leeuwen FW. PMID: 32632518; PMCID: PMC7423787.
      View in: PubMed   Mentions: 1     Fields:    
    14. Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. BMC Biol. 2020 02 24; 18(1):18. Alexander-Floyd J, Haroon S, Ying M, Entezari AA, Jaeger C, Vermulst M, Gidalevitz T. PMID: 32093691; PMCID: PMC7038566.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    15. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019 10 01; 125:110675. Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S. PMID: 31344454; PMCID: PMC6857812.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    16. Oxygen Consumption Measurements in Caenorhabditis elegans Using the Seahorse XF24. Bio Protoc. 2019 Jul 05; 9(13):e3288. Haroon S, Vermulst M. PMID: 33654802; PMCID: PMC7854111.
      View in: PubMed   Mentions: 1  
    17. Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms. J Vis Exp. 2018 09 13; (139). Fritsch C, Gout JP, Vermulst M. PMID: 30272673; PMCID: PMC6235186.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metab. 2019 01 08; 29(1):78-90.e5. McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC. PMID: 30174309; PMCID: PMC6717513.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    19. Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 06; 135(6):811-826. Verheijen BM, Vermulst M, van Leeuwen FW. PMID: 29705908; PMCID: PMC5954077.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    20. Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Rep. 2018 03 20; 22(12):3115-3125. Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M. PMID: 29562168; PMCID: PMC6106782.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    21. The landscape of transcription errors in eukaryotic cells. Sci Adv. 2017 10; 3(10):e1701484. Gout JF, Li W, Fritsch C, Li A, Haroon S, Singh L, Hua D, Fazelinia H, Smith Z, Seeholzer S, Thomas K, Lynch M, Vermulst M. PMID: 29062891; PMCID: PMC5650487.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    22. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017; 12(2):e0171159. Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. PMID: 28158260; PMCID: PMC5291490.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    23. Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 06; 38:68-74. Haroon S, Vermulst M. PMID: 27235806.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    24. Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Oct 14; 6:8738. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. PMID: 26465398.
      View in: PubMed   Mentions:    Fields:    
    25. Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Aug 25; 6:8065. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Mosely AM, Thompson JW, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. PMID: 26304740; PMCID: PMC4684168.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    26. Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet. 2012; 8(6):e1002689. Ericson NG, Kulawiec M, Vermulst M, Sheahan K, O'Sullivan J, Salk JJ, Bielas JH. PMID: 22685414; PMCID: PMC3369930.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    27. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010 Apr 16; 141(2):280-9. Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. PMID: 20403324; PMCID: PMC2876819.
      View in: PubMed   Mentions: 591     Fields:    Translation:AnimalsCells
    28. On mitochondria, mutations, and methodology. Cell Metab. 2009 Dec; 10(6):437. Vermulst M, Wanagat J, Loeb LA. PMID: 19945399.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    29. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 2009 Jun 02; 119(21):2789-97. Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. PMID: 19451351; PMCID: PMC2858759.
      View in: PubMed   Mentions: 263     Fields:    Translation:AnimalsCells
    30. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec; 46(4):263-8. Vermulst M, Bielas JH, Loeb LA. PMID: 18948200; PMCID: PMC2615251.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    31. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr; 40(4):392-4. Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. PMID: 18311139.
      View in: PubMed   Mentions: 207     Fields:    Translation:AnimalsCells
    32. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr; 39(4):540-3. Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. PMID: 17334366.
      View in: PubMed   Mentions: 198     Fields:    Translation:AnimalsCells
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