Giorgia Quadrato

Title(s)Assistant Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of Usc
Address1425 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Dr. Quadrato's laboratory focuses on understanding the cellular and molecular basis of human brain development and disease. By combining the use of emerging models of the human brain with single cell omics approaches, the laboratory is aiming to identify cell type specific disease mechanisms, and above all, new treatments for human neurodevelopmental disorders.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Human cerebellar organoids with functional Purkinje cells. Cell Stem Cell. 2024 01 04; 31(1):39-51.e6. Atamian A, Birtele M, Hosseini N, Nguyen T, Seth A, Del Dosso A, Paul S, Tedeschi N, Taylor R, Coba MP, Samarasinghe R, Lois C, Quadrato G. PMID: 38181749.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis. Nat Neurosci. 2023 Dec; 26(12):2090-2103. Birtele M, Del Dosso A, Xu T, Nguyen T, Wilkinson B, Hosseini N, Nguyen S, Urenda JP, Knight G, Rojas C, Flores I, Atamian A, Moore R, Sharma R, Pirrotte P, Ashton RS, Huang EJ, Rumbaugh G, Coba MP, Quadrato G. PMID: 37946050.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    3. Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids. Biol Psychiatry. 2023 04 01; 93(7):606-615. Urenda JP, Del Dosso A, Birtele M, Quadrato G. PMID: 36759258.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Organoids as tools for fundamental discovery and translation-a Keystone Symposia report. Ann N Y Acad Sci. 2022 12; 1518(1):196-208. Cable J, Lutolf MP, Fu J, Park SE, Apostolou A, Chen S, Song CJ, Spence JR, Liberali P, Lancaster M, Meier AB, Pek NMQ, Wells JM, Capeling MM, Uzquiano A, Musah S, Huch M, Gouti M, Hombrink P, Quadrato G, Urenda JP. PMID: 36177906.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    5. Not all cortical organoids are created equal. Nat Cell Biol. 2022 06; 24(6):805-806. Atamian A, Birtele M, Quadrato G. PMID: 35697780.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    6. Autism genes converge on asynchronous development of shared neuron classes. Nature. 2022 02; 602(7896):268-273. Paulsen B, Velasco S, Kedaigle AJ, Pigoni M, Quadrato G, Deo AJ, Adiconis X, Uzquiano A, Sartore R, Yang SM, Simmons SK, Symvoulidis P, Kim K, Tsafou K, Podury A, Abbate C, Tucewicz A, Smith SN, Albanese A, Barrett L, Sanjana NE, Shi X, Chung K, Lage K, Boyden ES, Regev A, Levin JZ, Arlotta P. PMID: 35110736; PMCID: PMC8852827.
      View in: PubMed   Mentions: 97     Fields:    Translation:HumansCells
    7. Upgrading the Physiological Relevance of Human Brain Organoids. Neuron. 2020 09 23; 107(6):1014-1028. Del Dosso A, Urenda JP, Nguyen T, Quadrato G. PMID: 32970996; PMCID: PMC10042151.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    8. Taming human brain organoids one cell at a time. Semin Cell Dev Biol. 2021 03; 111:23-31. Atamian A, Cordón-Barris L, Quadrato G. PMID: 32718852.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    9. Guiding human development in a dish. Nat Methods. 2019 07; 16(7):585-586. Morsut L, Quadrato G. PMID: 31249404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    10. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019 06; 570(7762):523-527. Velasco S, Kedaigle AJ, Simmons SK, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin JZ, Arlotta P. PMID: 31168097; PMCID: PMC6906116.
      View in: PubMed   Mentions: 369     Fields:    Translation:HumansCells
    11. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr Top Dev Biol. 2018; 129:99-122. Brown J, Quadrato G, Arlotta P. PMID: 29801532.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    12. Present and future of modeling human brain development in 3D organoids. Curr Opin Cell Biol. 2017 12; 49:47-52. Quadrato G, Arlotta P. PMID: 29227864.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansCells
    13. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017 05 04; 545(7652):48-53. Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, Maria N, Scholvin J, Goldman M, Kinney JP, Boyden ES, Lichtman JW, Williams ZM, McCarroll SA, Arlotta P. PMID: 28445462; PMCID: PMC5659341.
      View in: PubMed   Mentions: 504     Fields:    Translation:HumansCells
    14. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016 11; 22(11):1220-1228. Quadrato G, Brown J, Arlotta P. PMID: 27783065.
      View in: PubMed   Mentions: 125     Fields:    Translation:HumansCells
    15. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016 Mar 03; 18(3):297-9. Quadrato G, Zhang AC, Arlotta P. PMID: 26942845.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    16. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015 Jul; 138(Pt 7):1843-62. Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Magali C, Marine JC, Puttagunta R, Di Giovanni S. PMID: 25981963.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    17. Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol. 2014 Nov; 16(11):1045-56. Ottone C, Krusche B, Whitby A, Clements M, Quadrato G, Pitulescu ME, Adams RH, Parrinello S. PMID: 25283993; PMCID: PMC4298702.
      View in: PubMed   Mentions: 141     Fields:    Translation:HumansAnimalsCells
    18. Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4. J Neurosci. 2014 Jun 18; 34(25):8630-45. Quadrato G, Elnaggar MY, Duman C, Sabino A, Forsberg K, Di Giovanni S. PMID: 24948817; PMCID: PMC6608211.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    19. Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement. Front Neurosci. 2014; 8:17. Quadrato G, Elnaggar MY, Di Giovanni S. PMID: 24574955; PMCID: PMC3921569.
      View in: PubMed   Mentions: 14  
    20. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci. 2013 Sep 04; 33(36):14318-30. Forsberg K, Wuttke A, Quadrato G, Chumakov PM, Wizenmann A, Di Giovanni S. PMID: 24005285; PMCID: PMC6618388.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    21. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J Neurosci. 2012 Oct 03; 32(40):13956-70. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S. PMID: 23035104; PMCID: PMC6704782.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    22. Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis. Cell Mol Life Sci. 2013 Mar; 70(6):993-1007. Quadrato G, Di Giovanni S. PMID: 22899311.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    23. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobiol. 2012 Oct; 46(2):227-41. Ferreira LM, Floriddia EM, Quadrato G, Di Giovanni S. PMID: 22717989.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimals
    24. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):E1499-508. Quadrato G, Benevento M, Alber S, Jacob C, Floriddia EM, Nguyen T, Elnaggar MY, Pedroarena CM, Molkentin JD, Di Giovanni S. PMID: 22586092; PMCID: PMC3384134.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    25. Gatekeeper between quiescence and differentiation: p53 in axonal outgrowth and neurogenesis. Int Rev Neurobiol. 2012; 105:71-89. Quadrato G, Di Giovanni S. PMID: 23206596.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    26. Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242. Br J Pharmacol. 2009 Sep; 158(1):382-91. Mancini I, Brusa R, Quadrato G, Foglia C, Scandroglio P, Silverman LS, Tulshian D, Reggiani A, Beltramo M. PMID: 19552692; PMCID: PMC2795250.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    27. Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice. J Neurosci. 2008 Apr 09; 28(15):3911-9. Denis-Donini S, Dellarole A, Crociara P, Francese MT, Bortolotto V, Quadrato G, Canonico PL, Orsetti M, Ghi P, Memo M, Bonini SA, Ferrari-Toninelli G, Grilli M. PMID: 18400889; PMCID: PMC6670458.
      View in: PubMed   Mentions: 79     Fields:    Translation:AnimalsCells
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