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Giorgia Quadrato

Title(s)Assistant Professor of Stem Cell Biology and Regenerative Medicine
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    Collapse Overview 
    Collapse Overview
    Dr. Quadrato's laboratory focuses on understanding the cellular and molecular basis of human brain development and disease. By combining the use of emerging models of the human brain with single cell omics approaches, the laboratory is aiming to identify cell type specific disease mechanisms, and above all, new treatments for human neurodevelopmental disorders.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Morsut L, Quadrato G. Guiding human development in a dish. Nat Methods. 2019 07; 16(7):585-586. PMID: 31249404.
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    2. Velasco S, Kedaigle AJ, Simmons SK, Nash A, Rocha M, Quadrato G, Paulsen B, Nguyen L, Adiconis X, Regev A, Levin JZ, Arlotta P. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019 Jun; 570(7762):523-527. PMID: 31168097.
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    3. Brown J, Quadrato G, Arlotta P. Studying the Brain in a Dish: 3D Cell Culture Models of Human Brain Development and Disease. Curr Top Dev Biol. 2018; 129:99-122. PMID: 29801532.
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    4. Quadrato G, Arlotta P. Present and future of modeling human brain development in 3D organoids. Curr Opin Cell Biol. 2017 12; 49:47-52. PMID: 29227864.
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    5. Quadrato G, Nguyen T, Macosko EZ, Sherwood JL, Min Yang S, Berger DR, Maria N, Scholvin J, Goldman M, Kinney JP, Boyden ES, Lichtman JW, Williams ZM, McCarroll SA, Arlotta P. Cell diversity and network dynamics in photosensitive human brain organoids. Nature. 2017 05 04; 545(7652):48-53. PMID: 28445462.
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    6. Quadrato G, Brown J, Arlotta P. The promises and challenges of human brain organoids as models of neuropsychiatric disease. Nat Med. 2016 11; 22(11):1220-1228. PMID: 27783065.
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    7. Quadrato G, Zhang AC, Arlotta P. Stressed out? Healing Tips for Newly Reprogrammed Neurons. Cell Stem Cell. 2016 Mar 03; 18(3):297-9. PMID: 26942845.
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    8. Joshi Y, Sória MG, Quadrato G, Inak G, Zhou L, Hervera A, Rathore KI, Elnaggar M, Cucchiarini M, Magali C, Marine JC, Puttagunta R, Di Giovanni S. The MDM4/MDM2-p53-IGF1 axis controls axonal regeneration, sprouting and functional recovery after CNS injury. Brain. 2015 Jul; 138(Pt 7):1843-62. PMID: 25981963.
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    9. Ottone C, Krusche B, Whitby A, Clements M, Quadrato G, Pitulescu ME, Adams RH, Parrinello S. Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells. Nat Cell Biol. 2014 Nov; 16(11):1045-56. PMID: 25283993.
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    10. Quadrato G, Elnaggar MY, Duman C, Sabino A, Forsberg K, Di Giovanni S. Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4. J Neurosci. 2014 Jun 18; 34(25):8630-45. PMID: 24948817.
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    11. Quadrato G, Elnaggar MY, Di Giovanni S. Adult neurogenesis in brain repair: cellular plasticity vs. cellular replacement. Front Neurosci. 2014; 8:17. PMID: 24574955.
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    12. Forsberg K, Wuttke A, Quadrato G, Chumakov PM, Wizenmann A, Di Giovanni S. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci. 2013 Sep 04; 33(36):14318-30. PMID: 24005285.
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    13. Floriddia EM, Rathore KI, Tedeschi A, Quadrato G, Wuttke A, Lueckmann JM, Kigerl KA, Popovich PG, Di Giovanni S. p53 Regulates the neuronal intrinsic and extrinsic responses affecting the recovery of motor function following spinal cord injury. J Neurosci. 2012 Oct 03; 32(40):13956-70. PMID: 23035104.
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    14. Quadrato G, Di Giovanni S. Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis. Cell Mol Life Sci. 2013 Mar; 70(6):993-1007. PMID: 22899311.
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    15. Ferreira LM, Floriddia EM, Quadrato G, Di Giovanni S. Neural regeneration: lessons from regenerating and non-regenerating systems. Mol Neurobiol. 2012 Oct; 46(2):227-41. PMID: 22717989.
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    16. Quadrato G, Benevento M, Alber S, Jacob C, Floriddia EM, Nguyen T, Elnaggar MY, Pedroarena CM, Molkentin JD, Di Giovanni S. Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus. Proc Natl Acad Sci U S A. 2012 Jun 05; 109(23):E1499-508. PMID: 22586092.
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    17. Quadrato G, Di Giovanni S. Gatekeeper between quiescence and differentiation: p53 in axonal outgrowth and neurogenesis. Int Rev Neurobiol. 2012; 105:71-89. PMID: 23206596.
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    18. Mancini I, Brusa R, Quadrato G, Foglia C, Scandroglio P, Silverman LS, Tulshian D, Reggiani A, Beltramo M. Constitutive activity of cannabinoid-2 (CB2) receptors plays an essential role in the protean agonism of (+)AM1241 and L768242. Br J Pharmacol. 2009 Sep; 158(1):382-91. PMID: 19552692.
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    19. Denis-Donini S, Dellarole A, Crociara P, Francese MT, Bortolotto V, Quadrato G, Canonico PL, Orsetti M, Ghi P, Memo M, Bonini SA, Ferrari-Toninelli G, Grilli M. Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice. J Neurosci. 2008 Apr 09; 28(15):3911-9. PMID: 18400889.
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