Leonardo Morsut

Title(s)Assistant Professor of Stem Cell Biology and Regenerative Medicine
SchoolKeck School of Medicine of Usc
AddressBCC 507 1425 San Pablo St
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 4363
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Synthetic development: dissection of morphogenetic programs via reconstructive and perturbative approaches
    NIH R35GM138256Sep 15, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact
    NIH R00EB021030Aug 1, 2017 - Apr 30, 2021
    Role: Principal Investigator
    Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact Signals
    NIH K99EB021030Aug 5, 2015 - Jul 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 Aug 01; 15(1):6490. Garibyan M, Hoffman T, Makaske T, Do SK, Wu Y, Williams BA, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson B, Santoso JW, Khademhosseini A, Thomson M, Li S, McCain ML, Morsut L. PMID: 39090120; PMCID: PMC11294467.
      View in: PubMed   Mentions:    Fields:    
    2. Engineering programmable material-to-cell pathways via synthetic notch receptors to spatially control differentiation in multicellular constructs. Nat Commun. 2024 Jul 13; 15(1):5891. Garibyan M, Hoffman T, Makaske T, Do SK, Wu Y, Williams BA, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson B, Santoso JW, Khademhosseini A, Thomson M, Li S, McCain ML, Morsut L. PMID: 39003263; PMCID: PMC11246427.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Parsing patterns: Emerging roles of tissue self-organization in health and disease. Cell. 2024 Jun 20; 187(13):3165-3186. Ramos R, Swedlund B, Ganesan AK, Morsut L, Maini PK, Monuki ES, Lander AD, Chuong CM, Plikus MV. PMID: 38906093; PMCID: PMC11299420.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Programming Juxtacrine-Based Synthetic Signaling Networks in a Cellular Potts Framework. Methods Mol Biol. 2024; 2760:283-307. Lam C, Morsut L. PMID: 38468095.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Engineering Programmable Material-To-Cell Pathways Via Synthetic Notch Receptors To Spatially Control Cellular Phenotypes In Multi-Cellular Constructs. bioRxiv. 2023 May 20. Garibyan M, Hoffman T, Makaske T, Do S, March AR, Cho N, Pedroncelli N, Lima RE, Soto J, Jackson B, Khademhosseini A, Li S, McCain M, Morsut L. PMID: 37293089; PMCID: PMC10245658.
      View in: PubMed   Mentions:
    6. The sound of silence: Transgene silencing in mammalian cell engineering. Cell Syst. 2022 12 21; 13(12):950-973. Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS, Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. PMID: 36549273; PMCID: PMC9880859.
      View in: PubMed   Mentions: 22     Fields:    Translation:Animals
    7. Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion. ACS Synth Biol. 2022 04 15; 11(4):1417-1439. Lam C, Saluja S, Courcoubetis G, Yu D, Chung C, Courte J, Morsut L. PMID: 35363477; PMCID: PMC10389258.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. The living interface between synthetic biology and biomaterial design. Nat Mater. 2022 04; 21(4):390-397. Liu AP, Appel EA, Ashby PD, Baker BM, Franco E, Gu L, Haynes K, Joshi NS, Kloxin AM, Kouwer PHJ, Mittal J, Morsut L, Noireaux V, Parekh S, Schulman R, Tang SKY, Valentine MT, Vega SL, Weber W, Stephanopoulos N, Chaudhuri O. PMID: 35361951; PMCID: PMC10265650.
      View in: PubMed   Mentions: 29     Fields:    
    9. The evolution of synthetic receptor systems. Nat Chem Biol. 2022 03; 18(3):244-255. Manhas J, Edelstein HI, Leonard JN, Morsut L. PMID: 35058646; PMCID: PMC9041813.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    10. Novel synthetic biology approaches for developmental systems. Stem Cell Reports. 2021 05 11; 16(5):1051-1064. Ho C, Morsut L. PMID: 33979593; PMCID: PMC8185972.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
    11. How Has the COVID-19 Pandemic Changed How You Will Approach Research and Lab Work in the Future? Cell Syst. 2020 12 16; 11(6):550-554. Haynes K, Yau C, Bild A, Laughney A, Morsut L, Yang X, Zaugg J, Hsu P, Pancaldi V, Iyer-Biswas S. PMID: 33333028; PMCID: PMC7833873.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    12. Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 09 25; 9(3):221-227. Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE. PMID: 31557453; PMCID: PMC7577355.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    13. Guiding human development in a dish. Nat Methods. 2019 07; 16(7):585-586. Morsut L, Quadrato G. PMID: 31249404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    14. Synthetic development: building mammalian multicellular structures with artificial genetic programs. Curr Opin Biotechnol. 2019 10; 59:130-140. Santorelli M, Lam C, Morsut L. PMID: 31128430; PMCID: PMC6778502.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    15. Tissue Patterning: The Winner Takes It All, the Losers Standing Small. Curr Biol. 2019 05 06; 29(9):R334-R337. Dupont S, Morsut L. PMID: 31063728.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    16. Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science. 2018 07 13; 361(6398):156-162. Toda S, Blauch LR, Tang SKY, Morsut L, Lim WA. PMID: 29853554; PMCID: PMC6492944.
      View in: PubMed   Mentions: 156     Fields:    Translation:Cells
    17. Engineering multicellular systems: using synthetic biology to control tissue self-organization. Curr Opin Biomed Eng. 2017 Dec; 4:163-173. Johnson MB, March AR, Morsut L. PMID: 29308442; PMCID: PMC5749256.
      View in: PubMed   Mentions: 22  
    18. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. PMID: 27693353; PMCID: PMC5072533.
      View in: PubMed   Mentions: 271     Fields:    Translation:HumansCells
    19. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. PMID: 26830878; PMCID: PMC4752866.
      View in: PubMed   Mentions: 387     Fields:    Translation:HumansAnimalsCells
    20. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. PMID: 26830879; PMCID: PMC4752902.
      View in: PubMed   Mentions: 436     Fields:    Translation:HumansAnimalsCells
    21. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. PMID: 23849981; PMCID: PMC3770145.
      View in: PubMed   Mentions: 1644     Fields:    Translation:HumansAnimalsCells
    22. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 2011 Sep 25; 13(11):1368-75. Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S. PMID: 21947082.
      View in: PubMed   Mentions: 113     Fields:    Translation:HumansAnimalsCells
    23. Role of YAP/TAZ in mechanotransduction. Nature. 2011 Jun 08; 474(7350):179-83. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S. PMID: 21654799.
      View in: PubMed   Mentions: 2543     Fields:    Translation:HumansAnimalsCells
    24. Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 01; 137(15):2571-8. Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S. PMID: 20573697.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    25. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009 Jan 09; 136(1):123-35. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S. PMID: 19135894.
      View in: PubMed   Mentions: 271     Fields:    Translation:AnimalsCells
    26. MicroRNA control of Nodal signalling. Nature. 2007 Sep 13; 449(7159):183-8. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O, Piccolo S. PMID: 17728715.
      View in: PubMed   Mentions: 91     Fields:    Translation:AnimalsCells
    27. Microvascular patterns in human medullary tegmentum at the level of the area postrema. J Anat. 2005 Apr; 206(4):405-10. Porzionato A, Macchi V, Morsut L, Parenti A, De Caro R. PMID: 15817108; PMCID: PMC1571483.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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