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Leonardo Morsut

Title(s)Assistant Professor of Stem Cell Biology and Regenerative Medicine
Phone+1 323 442 4363
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact
    NIH/NIBIB R00EB021030Aug 1, 2017 - Apr 30, 2020
    Role: Principal Investigator
    Engineering Synthetic Receptor Systems That Can Detect Specific Cell-Cell Contact Signals
    NIH/NIBIB K99EB021030Aug 5, 2015 - Jul 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yu W, Marshall WF, Metzger RJ, Brakeman PR, Morsut L, Lim W, Mostov KE. Simple Rules Determine Distinct Patterns of Branching Morphogenesis. Cell Syst. 2019 Sep 25; 9(3):221-227. PMID: 31557453.
      View in: PubMed
    2. Morsut L, Quadrato G. Guiding human development in a dish. Nat Methods. 2019 07; 16(7):585-586. PMID: 31249404.
      View in: PubMed
    3. Santorelli M, Lam C, Morsut L. Synthetic development: building mammalian multicellular structures with artificial genetic programs. Curr Opin Biotechnol. 2019 May 22; 59:130-140. PMID: 31128430.
      View in: PubMed
    4. Dupont S, Morsut L. Tissue Patterning: The Winner Takes It All, the Losers Standing Small. Curr Biol. 2019 May 06; 29(9):R334-R337. PMID: 31063728.
      View in: PubMed
    5. Toda S, Blauch LR, Tang SKY, Morsut L, Lim WA. Programming self-organizing multicellular structures with synthetic cell-cell signaling. Science. 2018 07 13; 361(6398):156-162. PMID: 29853554.
      View in: PubMed
    6. Johnson MB, March AR, Morsut L. Engineering multicellular systems: using synthetic biology to control tissue self-organization. Curr Opin Biomed Eng. 2017 Dec; 4:163-173. PMID: 29308442.
      View in: PubMed
    7. Roybal KT, Williams JZ, Morsut L, Rupp LJ, Kolinko I, Choe JH, Walker WJ, McNally KA, Lim WA. Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell. 2016 Oct 06; 167(2):419-432.e16. PMID: 27693353.
      View in: PubMed
    8. Morsut L, Roybal KT, Xiong X, Gordley RM, Coyle SM, Thomson M, Lim WA. Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors. Cell. 2016 Feb 11; 164(4):780-91. PMID: 26830878.
      View in: PubMed
    9. Roybal KT, Rupp LJ, Morsut L, Walker WJ, McNally KA, Park JS, Lim WA. Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits. Cell. 2016 Feb 11; 164(4):770-9. PMID: 26830879.
      View in: PubMed
    10. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981.
      View in: PubMed
    11. Inui M, Manfrin A, Mamidi A, Martello G, Morsut L, Soligo S, Enzo E, Moro S, Polo S, Dupont S, Cordenonsi M, Piccolo S. USP15 is a deubiquitylating enzyme for receptor-activated SMADs. Nat Cell Biol. 2011 Sep 25; 13(11):1368-75. PMID: 21947082.
      View in: PubMed
    12. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S. Role of YAP/TAZ in mechanotransduction. Nature. 2011 Jun 08; 474(7350):179-83. PMID: 21654799.
      View in: PubMed
    13. Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S. Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 01; 137(15):2571-8. PMID: 20573697.
      View in: PubMed
    14. Dupont S, Mamidi A, Cordenonsi M, Montagner M, Zacchigna L, Adorno M, Martello G, Stinchfield MJ, Soligo S, Morsut L, Inui M, Moro S, Modena N, Argenton F, Newfeld SJ, Piccolo S. FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination. Cell. 2009 Jan 09; 136(1):123-35. PMID: 19135894.
      View in: PubMed
    15. Martello G, Zacchigna L, Inui M, Montagner M, Adorno M, Mamidi A, Morsut L, Soligo S, Tran U, Dupont S, Cordenonsi M, Wessely O, Piccolo S. MicroRNA control of Nodal signalling. Nature. 2007 Sep 13; 449(7159):183-8. PMID: 17728715.
      View in: PubMed
    16. Porzionato A, Macchi V, Morsut L, Parenti A, De Caro R. Microvascular patterns in human medullary tegmentum at the level of the area postrema. J Anat. 2005 Apr; 206(4):405-10. PMID: 15817108.
      View in: PubMed