Zarko Manojlovic

Title(s)Assistant Professor of Research Urology
SchoolKeck School of Medicine of Usc
Address1441 East Lake Avenue
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 1595
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    Dr. Manojlovic in an Assistant Professor in the department of Translational Genomics and the Director of the newly formed Keck Genomics Platform (KGP) at the Keck School of Medicine of University of Southern California. In 2017, with support of Keck Medicine led the creation of the state-of-the-art next generation sequencing center with emphasis on multi-disciplinary collaborative projects. KGP is a service platform designed to support Keck School of Medicine, greater USC, and its affiliates with a complete, high throughput next generation sequencing ecosystem that can support projects at all stages of development. KGP provides support in high quality sample processing, library constructions, and high throughput next generation sequencing of RNA, whole genome, exome, bi-sulfide, methylome, esoteric, and custom targeted assays by utilizing the Illumina platform such as MiSeq and NovaSeq. KGP also leverages high performance computational resources with in-house built pipelines and information management systems vital for a complete research-based precision medicine platform. KGP’s major mission is to build a collaborative environment and provide team-driven research support within the scope of the next generation technologies to ultimately drive advances in translational genomics and pave a way towards personalized medicine.

    Dr. Manojlovic earned his Ph.D. from Florida State University College of Medicine with a focus on delineating clinically actionable fibro-proliferative mechanisms in liver fibrosis and developmental disorders linked to ciliopathies. He then went on to complete his postdoctoral fellowship in the lab of Dr. John D.Carpten. Under Dr. Carpten’s mentorship and a fruitful opportunity of co-mentoring by Drs. Jeff Trent, Jonathan Keats, Winnie Liang, and David W. Craig, resulted in Dr. Manojlovic processing over 250Tbs of raw sequencing data on studies focusing on a wide spectrum of somatic landscapes across melanoma, prostate cancer, multiple myeloma as part of the large Multiple Myeloma Research Foundation Personalized Medicine CoMMpaSS study, colorectal cancer, pediatric sarcomas in collaboration with Dr. Troy A. McEachron and Children Hospital of Orange County, B-cell lymphoma, breast, kidney, prostate, and bladder cancers. He also worked on health disparities research and tumor population heterogeneity. In addition, Dr. Manojlovic helped build the laboratory component that is utilized to support the new Department of Translational Genomics and Keck Genomics Platform where he was promoted to an Assistant Professor of Translational Genomics and Director of Keck Genomics Platform.

    In his role as an Assistant Professor, Dr. Manojlovic has a continued interest in urothelial carcinomas, with a focus on utilizing next generation sequencing and “omics” to elucidate population and tumor heterogeneity, as well as tumor microenvironments at the nexus of informatics and functional biologics with direct clinical implications. Dr. Manojlovic plans to expand profiling and comprehensive molecular analysis of the organ-confined elusive low-grade heterogeneous urothelial carcinomas that escape standard treatments and escalate into aggressive high-risk tumors with a high rate of mortality. Furthermore, building on his previous experiences with continuous collaborations, Dr. Manojlovic is interested in interrogating the ancestral effects on disease progression and outcomes in the urothelial tumors. His group provides opportunities in dual training in functional bioinformatics with emphasis on clinical biologics approaches. Dr. Manojlovic has a major focus on applications of high throughput genomics critical to elucidate the oncogenic transcriptomes and genomes to identify clinically targetable events under the umbrella of precision medicine.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Common mitochondrial deletions in RNA-Seq: evaluation of bulk, single-cell, and spatial transcriptomic datasets. Commun Biol. 2024 Feb 17; 7(1):200. Omidsalar AA, McCullough CG, Xu L, Boedijono S, Gerke D, Webb MG, Manojlovic Z, Sequeira A, Lew MF, Santorelli M, Serrano GE, Beach TG, Limon A, Vawter MP, Hjelm BE. PMID: 38368460; PMCID: PMC10874445.
      View in: PubMed   Mentions: Translation:HumansCells
    2. Construction of high coverage whole-genome sequencing libraries from single colon crypts without DNA extraction or whole-genome amplification. BMC Res Notes. 2023 Apr 27; 16(1):66. Manojlovic Z, Wlodarczyk J, Okitsu C, Jin Y, Van Den Berg D, Lieber MR, Hsieh CL. PMID: 37106434; PMCID: PMC10142246.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN Amplification: A Children's Oncology Group (COG) Report. Clin Cancer Res. 2023 04 14; 29(8):1546-1556. Pinto N, Naranjo A, Ding X, Zhang FF, Hibbitts E, Kennedy R, Tibbetts R, Wong-Michalak S, Craig DW, Manojlovic Z, Hogarty MD, Kreissman S, Bagatell R, Irwin MS, Park JR, Asgharzadeh S. PMID: 36749880; PMCID: PMC10106446.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    4. Evolutionary conservation of the fidelity of transcription. Nat Commun. 2023 03 20; 14(1):1547. Chung C, Verheijen BM, Navapanich Z, McGann EG, Shemtov S, Lai GJ, Arora P, Towheed A, Haroon S, Holczbauer A, Chang S, Manojlovic Z, Simpson S, Thomas KW, Kaplan C, van Hasselt P, Timmers M, Erie D, Chen L, Gout JF, Vermulst M. PMID: 36941254; PMCID: PMC10027832.
      View in: PubMed   Mentions:    Fields:    
    5. Genome Analysis Using Whole-Exome Sequencing of Non-Syndromic Cleft Lip and/or Palate from Malagasy Trios Identifies Variants Associated with Cilium-Related Pathways and Asian Genetic Ancestry. Genes (Basel). 2023 03 07; 14(3). Manojlovic Z, Auslander A, Jin Y, Schmidt RJ, Xu Y, Chang S, Song R, Ingles SA, Nunes A, Vavra KC, Feigelson D, Rakotoarison S, DiBona M, Magee K, Smile O, Ramamonjisoa A, Magee Iii W. PMID: 36980938; PMCID: PMC10048728.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. High prevalence of deleterious mutations in concomitant nonsyndromic cleft and outflow tract heart defects. Am J Med Genet A. 2022 07; 188(7):2082-2095. Munabi NCO, Mikhail S, Toubat O, Webb M, Auslander A, Sanchez-Lara PA, Manojlovic Z, Schmidt RJ, Craig D, Magee WP, Kumar SR. PMID: 35385219; PMCID: PMC9197864.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    7. Analysis of the genomic landscapes of Barbadian and Nigerian women with triple negative breast cancer. Cancer Causes Control. 2022 Jun; 33(6):831-841. Hercules SM, Liu X, Bassey-Archibong BBI, Skeete DHA, Smith Connell S, Daramola A, Banjo AA, Ebughe G, Agan T, Ekanem IO, Udosen J, Obiorah C, Ojule AC, Misauno MA, Dauda AM, Egbujo EC, Hercules JC, Ansari A, Brain I, MacColl C, Xu Y, Jin Y, Chang S, Carpten JD, Bédard A, Pond GR, Blenman KRM, Manojlovic Z, Daniel JM. PMID: 35384527; PMCID: PMC9085672.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    8. Correction: Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Oncogene. 2021 Nov; 40(45):6394. Leonard MK, Puts GS, Pamidimukkala N, Adhikary G, Xu Y, Kwok E, Jin Y, Snyder D, Matsangos N, Novak M, Mahurkar A, Shetty AC, Slominski RM, De Fabo EC, Noonan FP, Day CP, Rigi M, Slominski AT, Webb MG, Craig DW, Merlino G, Eckert RL, Carpten JD, Manojlovic Z, Kaetzel DM. PMID: 34635800.
      View in: PubMed   Mentions:    Fields:    
    9. Wild-Type KRAS Allele Effects on Druggable Targets in KRAS Mutant Lung Adenocarcinomas. Genes (Basel). 2021 09 11; 12(9). Baldelli E, El Gazzah E, Moran JC, Hodge KA, Manojlovic Z, Bassiouni R, Carpten JD, Ludovini V, Baglivo S, Crinò L, Bianconi F, Dong T, Loffredo J, Petricoin EF, Pierobon M. PMID: 34573384; PMCID: PMC8467269.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients. Oncogene. 2021 11; 40(45):6329-6342. Leonard MK, Puts GS, Pamidimukkala N, Adhikary G, Xu Y, Kwok E, Jin Y, Snyder D, Matsangos N, Novak M, Mahurkar A, Shetty AC, Slominski RM, De Fabo EC, Noonan FP, Day CP, Rigi M, Slominski AT, Webb MG, Craig DW, Merlino G, Eckert RL, Carpten JD, Manojlovic Z, Kaetzel DM. PMID: 34433909; PMCID: PMC8595820.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    11. Role of Ki-67, MRE11, and PD-L1 as Predictive Biomarkers for Recurrence Pattern in Muscle-invasive Bladder Cancer. Anticancer Res. 2021 Aug; 41(8):3851-3857. Fossum CC, Xiong Y, Magliocco A, Daneshmand S, Aron M, Mouw KW, Manojlovic Z, McCarthy S, Phuong C, Dorff T, Bhanvadia SK, Ballas LK. PMID: 34281845.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. Imaging of type I procollagen biosynthesis in cells reveals biogenesis in highly organized bodies; Collagenosomes. Matrix Biol Plus. 2021 Dec; 12:100076. Stefanovic B, Stefanovic L, Manojlovic Z. PMID: 34278289; PMCID: PMC8261018.
      View in: PubMed   Mentions: 1  
    13. What Genes Can Tell: A Closer Look at Vestibular Schwannoma. Otol Neurotol. 2020 04; 41(4):522-529. Aaron KA, Manojlovic Z, Tu N, Xu Y, Jin Y, Chang S, Kwok E, Webb M, Hurth K, Friedman RA. PMID: 32176142.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    14. Cancer transcriptomic profiling from rapidly enriched circulating tumor cells. Int J Cancer. 2020 05 15; 146(10):2845-2854. Morrison GJ, Cunha AT, Jojo N, Xu Y, Xu Y, Kwok E, Robinson P, Dorff T, Quinn D, Carpten J, Manojlovic Z, Goldkorn A. PMID: 32037533; PMCID: PMC7451020.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    15. Histological Validation of 11Carbon-Acetate Positron Emission Tomography/Computerized Tomography in Detecting Lymph Node Metastases in Prostate Cancer. J Urol. 2019 02; 201(2):332-341. Rajarubendra N, Almeida F, Manojlovic Z, Ohe C, Ahmadi N, Cacciamani G, Qiu M, Abreu A, Cai J, Miranda G, Stern MC, Carpten J, Kuhn P, Amin MB, Gill PS, Aron M, Gill IS. PMID: 30218760; PMCID: PMC9504582.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Discovery and evaluation of inhibitor of LARP6 as specific antifibrotic compound. Sci Rep. 2019 01 23; 9(1):326. Stefanovic B, Manojlovic Z, Vied C, Badger CD, Stefanovic L. PMID: 30674965; PMCID: PMC6344531.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis. 2018 12 13; 39(11):1331-1341. Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T, Salhia B, Carpten J, Llor X, Ellis NA. PMID: 30239619; PMCID: PMC6292413.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    18. Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases. PLoS Genet. 2017 Nov; 13(11):e1007087. Manojlovic Z, Christofferson A, Liang WS, Aldrich J, Washington M, Wong S, Rohrer D, Jewell S, Kittles RA, Derome M, Auclair D, Craig DW, Keats J, Carpten JD. PMID: 29166413; PMCID: PMC5699827.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    19. A method to reduce ancestry related germline false positives in tumor only somatic variant calling. BMC Med Genomics. 2017 10 19; 10(1):61. Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, Craig DW. PMID: 29052513; PMCID: PMC5649057.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    20. Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. Genome Res. 2017 04; 27(4):524-532. Liang WS, Hendricks W, Kiefer J, Schmidt J, Sekar S, Carpten J, Craig DW, Adkins J, Cuyugan L, Manojlovic Z, Halperin RF, Helland A, Nasser S, Legendre C, Hurley LH, Sivaprakasam K, Johnson DB, Crandall H, Busam KJ, Zismann V, Deluca V, Lee J, Sekulic A, Ariyan CE, Sosman J, Trent J. PMID: 28373299; PMCID: PMC5378171.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    21. La-related protein 6 controls ciliated cell differentiation. Cilia. 2017; 6:4. Manojlovic Z, Earwood R, Kato A, Perez D, Cabrera OA, Didier R, Megraw TL, Stefanovic B, Kato Y. PMID: 28344782; PMCID: PMC5364628.
      View in: PubMed   Mentions: 5  
    22. Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. J Adolesc Young Adult Oncol. 2016 09; 5(3):297-302. McEachron TA, Sender LS, Zabokrtsky KB, Kaltenecker B, Holmes WN, Cherni I, Manojlovic Z, Liao SY, Craig DW, Carpten JD, Torno LR. PMID: 26974246.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    23. RFX7 is required for the formation of cilia in the neural tube. Mech Dev. 2014 May; 132:28-37. Manojlovic Z, Earwood R, Kato A, Stefanovic B, Kato Y. PMID: 24530844; PMCID: PMC3976564.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    24. Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs. Mol Cell Biol. 2013 Oct; 33(19):3893-906. Vukmirovic M, Manojlovic Z, Stefanovic B. PMID: 23918805; PMCID: PMC3811873.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    25. Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. PLoS One. 2013; 8(6):e65897. Manojlovic Z, Blackmon J, Stefanovic B. PMID: 23755290; PMCID: PMC3670911.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    26. A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs. RNA. 2012 Feb; 18(2):321-34. Manojlovic Z, Stefanovic B. PMID: 22190748; PMCID: PMC3264918.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    27. Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J Neurosci. 2010 Jun 02; 30(22):7652-63. Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA. PMID: 20519540; PMCID: PMC2895424.
      View in: PubMed   Mentions: 59     Fields:    Translation:AnimalsCells
    28. Nicotine exposure during adolescence induces a depression-like state in adulthood. Neuropsychopharmacology. 2009 May; 34(6):1609-24. Iñiguez SD, Warren BL, Parise EM, Alcantara LF, Schuh B, Maffeo ML, Manojlovic Z, Bolaños-Guzmán CA. PMID: 19092782; PMCID: PMC2692426.
      View in: PubMed   Mentions: 75     Fields:    Translation:Animals
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