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Zarko Manojlovic

TitleAssistant Professor of Research Translational Genomics, Director of Keck Genomics Platform
InstitutionUniversity of Southern California
DepartmentDepartment of Translational Genomics
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 865 1595
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    Dr. Manojlovic in an Assistant Professor in the department of Translational Genomics and the Director of the newly formed Keck Genomics Platform (KGP) at the Keck School of Medicine of University of Southern California. In 2017, with support of Keck Medicine led the creation of the state-of-the-art next generation sequencing center with emphasis on multi-disciplinary collaborative projects. KGP is a service platform designed to support Keck School of Medicine, greater USC, and its affiliates with a complete, high throughput next generation sequencing ecosystem that can support projects at all stages of development. KGP provides support in high quality sample processing, library constructions, and high throughput next generation sequencing of RNA, whole genome, exome, bi-sulfide, methylome, esoteric, and custom targeted assays by utilizing the Illumina platform such as MiSeq and NovaSeq. KGP also leverages high performance computational resources with in-house built pipelines and information management systems vital for a complete research-based precision medicine platform. KGP’s major mission is to build a collaborative environment and provide team-driven research support within the scope of the next generation technologies to ultimately drive advances in translational genomics and pave a way towards personalized medicine.

    Dr. Manojlovic earned his Ph.D. from Florida State University College of Medicine with a focus on delineating clinically actionable fibro-proliferative mechanisms in liver fibrosis and developmental disorders linked to ciliopathies. He then went on to complete his postdoctoral fellowship in the lab of Dr. John D.Carpten. Under Dr. Carpten’s mentorship and a fruitful opportunity of co-mentoring by Drs. Jeff Trent, Jonathan Keats, Winnie Liang, and David W. Craig, resulted in Dr. Manojlovic processing over 250Tbs of raw sequencing data on studies focusing on a wide spectrum of somatic landscapes across melanoma, prostate cancer, multiple myeloma as part of the large Multiple Myeloma Research Foundation Personalized Medicine CoMMpaSS study, colorectal cancer, pediatric sarcomas in collaboration with Dr. Troy A. McEachron and Children Hospital of Orange County, B-cell lymphoma, breast, kidney, prostate, and bladder cancers. He also worked on health disparities research and tumor population heterogeneity. In addition, Dr. Manojlovic helped build the laboratory component that is utilized to support the new Department of Translational Genomics and Keck Genomics Platform where he was promoted to an Assistant Professor of Translational Genomics and Director of Keck Genomics Platform.

    In his role as an Assistant Professor, Dr. Manojlovic has a continued interest in urothelial carcinomas, with a focus on utilizing next generation sequencing and “omics” to elucidate population and tumor heterogeneity, as well as tumor microenvironments at the nexus of informatics and functional biologics with direct clinical implications. Dr. Manojlovic plans to expand profiling and comprehensive molecular analysis of the organ-confined elusive low-grade heterogeneous urothelial carcinomas that escape standard treatments and escalate into aggressive high-risk tumors with a high rate of mortality. Furthermore, building on his previous experiences with continuous collaborations, Dr. Manojlovic is interested in interrogating the ancestral effects on disease progression and outcomes in the urothelial tumors. His group provides opportunities in dual training in functional bioinformatics with emphasis on clinical biologics approaches. Dr. Manojlovic has a major focus on applications of high throughput genomics critical to elucidate the oncogenic transcriptomes and genomes to identify clinically targetable events under the umbrella of precision medicine.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xicola RM, Manojlovic Z, Augustus GJ, Kupfer SS, Emmadi R, Alagiozian-Angelova V, Triche T, Salhia B, Carpten J, Llor X, Ellis NA. Lack of APC somatic mutation is associated with early-onset colorectal cancer in African Americans. Carcinogenesis. 2018 Sep 15. PMID: 30239619.
      View in: PubMed
    2. Rajarubendra N, Almeida F, Manojlovic Z, Ohe C, Ahmadi N, Cacciamani G, Qiu M, Abreu A, Cai J, Miranda G, Stern MC, Carpten J, Kuhn P, Amin MB, Gill PS, Aron M, Gill IS. Histologic Validation of 11Carbon-Acetate Positron Emission Tomography/Computer Tomography in Detecting Lymph Node Metastases in Prostate Cancer. J Urol. 2018 Sep 12. PMID: 30218760.
      View in: PubMed
    3. Manojlovic Z, Christofferson A, Liang WS, Aldrich J, Washington M, Wong S, Rohrer D, Jewell S, Kittles RA, Derome M, Auclair D, Craig DW, Keats J, Carpten JD. Comprehensive molecular profiling of 718 Multiple Myelomas reveals significant differences in mutation frequencies between African and European descent cases. PLoS Genet. 2017 Nov; 13(11):e1007087. PMID: 29166413.
      View in: PubMed
    4. Halperin RF, Carpten JD, Manojlovic Z, Aldrich J, Keats J, Byron S, Liang WS, Russell M, Enriquez D, Claasen A, Cherni I, Awuah B, Oppong J, Wicha MS, Newman LA, Jaigge E, Kim S, Craig DW. A method to reduce ancestry related germline false positives in tumor only somatic variant calling. BMC Med Genomics. 2017 Oct 19; 10(1):61. PMID: 29052513.
      View in: PubMed
    5. Liang WS, Hendricks W, Kiefer J, Schmidt J, Sekar S, Carpten J, Craig DW, Adkins J, Cuyugan L, Manojlovic Z, Halperin RF, Helland A, Nasser S, Legendre C, Hurley LH, Sivaprakasam K, Johnson DB, Crandall H, Busam KJ, Zismann V, Deluca V, Lee J, Sekulic A, Ariyan CE, Sosman J, Trent J. Integrated genomic analyses reveal frequent TERT aberrations in acral melanoma. Genome Res. 2017 04; 27(4):524-532. PMID: 28373299.
      View in: PubMed
    6. Manojlovic Z, Earwood R, Kato A, Perez D, Cabrera OA, Didier R, Megraw TL, Stefanovic B, Kato Y. La-related protein 6 controls ciliated cell differentiation. Cilia. 2017; 6:4. PMID: 28344782.
      View in: PubMed
    7. McEachron TA, Sender LS, Zabokrtsky KB, Kaltenecker B, Holmes WN, Cherni I, Manojlovic Z, Liao SY, Craig DW, Carpten JD, Torno LR. Molecular Genetic Profiling of Adolescent Glassy Cell Carcinoma of the Cervix Reveals Targetable EGFR Amplification with Potential Therapeutic Implications. J Adolesc Young Adult Oncol. 2016 Sep; 5(3):297-302. PMID: 26974246.
      View in: PubMed
    8. Manojlovic Z, Earwood R, Kato A, Stefanovic B, Kato Y. RFX7 is required for the formation of cilia in the neural tube. Mech Dev. 2014 May; 132:28-37. PMID: 24530844; PMCID: PMC3976564.
    9. Vukmirovic M, Manojlovic Z, Stefanovic B. Serine-threonine kinase receptor-associated protein (STRAP) regulates translation of type I collagen mRNAs. Mol Cell Biol. 2013 Oct; 33(19):3893-906. PMID: 23918805; PMCID: PMC3811873.
    10. Manojlovic Z, Blackmon J, Stefanovic B. Tacrolimus (FK506) prevents early stages of ethanol induced hepatic fibrosis by targeting LARP6 dependent mechanism of collagen synthesis. PLoS One. 2013; 8(6):e65897. PMID: 23755290.
      View in: PubMed
    11. Manojlovic Z, Stefanovic B. A novel role of RNA helicase A in regulation of translation of type I collagen mRNAs. RNA. 2012 Feb; 18(2):321-34. PMID: 22190748; PMCID: PMC3264918.
    12. Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA. Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress. J Neurosci. 2010 Jun 02; 30(22):7652-63. PMID: 20519540; PMCID: PMC2895424.
    13. Iñiguez SD, Warren BL, Parise EM, Alcantara LF, Schuh B, Maffeo ML, Manojlovic Z, Bolaños-Guzmán CA. Nicotine exposure during adolescence induces a depression-like state in adulthood. Neuropsychopharmacology. 2009 May; 34(6):1609-24. PMID: 19092782; PMCID: PMC2692426.
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