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Comparison of human pluripotent stem cell differentiation protocols to generate neuroblastoma tumors. Sci Rep. 2024 10 04; 14(1):23050.
Cheng B, Fang W, Pastor S, March AR, Porras T, Wu HW, Velez M, Parekh C, Maris JM, Asgharzadeh S, Huang M. PMID: 39367051; PMCID: PMC11452544.
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PubMed Mentions: Fields:
Translation:
HumansAnimalsCells
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Identification and characterization of chemotherapy resistant high-risk neuroblastoma persister cells. Cancer Discov. 2024 Jul 31.
Grossmann LD, Chen CH, Uzun Y, Thadi A, Wolpaw AJ, Louault K, Goldstein Y, Surrey LF, Martinez D, Calafatti M, Gerelus M, Gao P, Lee L, Patel K, Kaufman RS, Shani G, Farrel A, Moshitch-Moshkovitz S, Grimaldi P, Shapiro M, Kendsersky NM, Lindsay JM, Casey CE, Krytska K, Scolaro L, Tsang M, Groff D, Matkar S, Kalna JR, Mycek E, McDevitt J, Runbeck E, Patel T, Bernt KM, Asgharzadeh S, DeClerck YA, Mosse YP, Tan K, Maris JM. PMID: 39083807.
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PubMed Mentions: Fields:
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Nuclear factor-κB activation by transforming growth factor-β1 drives tumour microenvironment-mediated drug resistance in neuroblastoma. Br J Cancer. 2024 Jul; 131(1):90-100.
Louault K, Blavier L, Lee MH, Kennedy RJ, Fernandez GE, Pawel BR, Asgharzadeh S, DeClerck YA. PMID: 38806726; PMCID: PMC11231159.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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ALK upregulates POSTN and WNT signaling to drive neuroblastoma. Cell Rep. 2024 Mar 26; 43(3):113927.
Huang M, Fang W, Farrel A, Li L, Chronopoulos A, Nasholm N, Cheng B, Zheng T, Yoda H, Barata MJ, Porras T, Miller ML, Zhen Q, Ghiglieri L, McHenry L, Wang L, Asgharzadeh S, Park J, Gustafson WC, Matthay KK, Maris JM, Weiss WA. PMID: 38451815; PMCID: PMC11101011.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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AF1q is a universal marker of neuroblastoma that sustains N-Myc expression and drives tumorigenesis. Oncogene. 2024 Apr; 43(16):1203-1213.
Oskouian B, Lee JY, Asgharzadeh S, Khan R, Zhang M, Weisbrod JR, Choi YJ, Puri L, Aguilar AE, Zhao P, Saba JD. PMID: 38413795; PMCID: PMC11014797.
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PubMed Mentions: Fields:
Translation:
HumansCells
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Anti-CCL2 antibody combined with etoposide prolongs survival in a minimal residual disease mouse model of neuroblastoma. Sci Rep. 2023 11 14; 13(1):19915.
Lascano D, Zobel MJ, Lee WG, Chen SY, Zamora A, Asuelime GE, Choi SY, Chronopoulos A, Asgharzadeh S, Marachelian A, Park J, Sheard MA, Kim ES. PMID: 37964011; PMCID: PMC10645976.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without MYCN Amplification: A Children's Oncology Group (COG) Report. Clin Cancer Res. 2023 04 14; 29(8):1546-1556.
Pinto N, Naranjo A, Ding X, Zhang FF, Hibbitts E, Kennedy R, Tibbetts R, Wong-Michalak S, Craig DW, Manojlovic Z, Hogarty MD, Kreissman S, Bagatell R, Irwin MS, Park JR, Asgharzadeh S. PMID: 36749880; PMCID: PMC10106446.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children's Oncology Group. J Immunother Cancer. 2023 02; 11(2).
Erbe AK, Diccianni MB, Mody R, Naranjo A, Zhang FF, Birstler J, Kim K, Feils AS, Hung JT, London WB, Shulkin BL, Mathew V, Parisi MT, Servaes S, Asgharzadeh S, Maris JM, Park J, Yu AL, Sondel PM, Bagatell R. PMID: 36822669; PMCID: PMC9950969.
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PubMed Mentions:
4 Fields:
Translation:
HumansCells
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Fibroblasts and macrophages cooperate to create a pro-tumorigenic and immune resistant environment via activation of TGF-β/IL-6 pathway in neuroblastoma. Oncoimmunology. 2022; 11(1):2146860.
Louault K, Porras T, Lee MH, Muthugounder S, Kennedy RJ, Blavier L, Sarte E, Fernandez GE, Yang F, Pawel BR, Shimada H, Asgharzadeh S, DeClerck YA. PMID: 36479153; PMCID: PMC9721439.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimalsCells
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Genome wide DNA methylation analysis identifies novel molecular subgroups and predicts survival in neuroblastoma. Br J Cancer. 2022 11; 127(11):2006-2015.
Lalchungnunga H, Hao W, Maris JM, Asgharzadeh S, Henrich KO, Westermann F, Tweddle DA, Schwalbe EC, Strathdee G. PMID: 36175618; PMCID: PMC9681858.
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PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Expression of neuroblastoma-related genes in bone marrow at end of high-risk neuroblastoma therapy. Pediatr Blood Cancer. 2022 09; 69(9):e29719.
Asgharzadeh S, Marachelian A, Villablanca JG, Liu WY, Kennedy R, Sposto R, Naranjo A, Tenney S, Yu AL, Ozkaynak MF, Sondel PM, Park JR, Seeger RC. PMID: 35441784; PMCID: PMC9329214.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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Adaptation of Imaging Mass Cytometry to Explore the Single Cell Alloimmune Landscape of Liver Transplant Rejection. Front Immunol. 2022; 13:831103.
Ung N, Goldbeck C, Man C, Hoeflich J, Sun R, Barbetta A, Matasci N, Katz J, Lee JSH, Chopra S, Asgharzadeh S, Warren M, Sher L, Kohli R, Akbari O, Genyk Y, Emamaullee J. PMID: 35432320; PMCID: PMC9009043.
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PubMed Mentions:
7 Fields:
Translation:
Humans
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Ultra-High Dose Vitamin D in Pediatric Hematopoietic Stem Cell Transplantation: A Nonrandomized Controlled Trial. Transplant Cell Ther. 2021 12; 27(12):1001.e1-1001.e9.
Bhandari R, Aguayo-Hiraldo P, Malvar J, Cheng K, Sacapano A, Abdel-Azim H, Chi YY, Wallace G, Asgharzadeh S, Jodele S, Orgel E. PMID: 34500127.
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PubMed Mentions:
2 Fields:
Translation:
HumansCTClinical Trials
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Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 10 10; 39(29):3229-3241.
Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. PMID: 34319759; PMCID: PMC8500606.
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PubMed Mentions:
122 Fields:
Translation:
Humans
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Anti-disialoganglioside antibody internalization by neuroblastoma cells as a mechanism of immunotherapy resistance. Cancer Immunol Immunother. 2022 Jan; 71(1):153-164.
Tibbetts R, Yeo KK, Muthugounder S, Lee MH, Jung C, Porras-Corredor T, Sheard MA, Asgharzadeh S. PMID: 34043024; PMCID: PMC10991857.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Myeloablative Busulfan/Melphalan Consolidation following Induction Chemotherapy for Patients with Newly Diagnosed High-Risk Neuroblastoma: Children's Oncology Group Trial ANBL12P1. Transplant Cell Ther. 2021 06; 27(6):490.e1-490.e8.
Granger MM, Naranjo A, Bagatell R, DuBois SG, McCune JS, Tenney SC, Weiss BD, Mosse YP, Asgharzadeh S, Grupp SA, Hogarty MD, Gastier-Foster JM, Mills D, Shulkin BL, Parisi MT, London WB, Han-Chang J, Panoff J, von Allmen D, Jarzembowski JA, Park JR, Yanik GA. PMID: 33823167; PMCID: PMC8855886.
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PubMed Mentions:
12 Fields:
Translation:
Humans
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Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma. Nat Commun. 2021 01 21; 12(1):511.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S. PMID: 33479234; PMCID: PMC7820416.
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PubMed Mentions:
65 Fields:
Translation:
HumansAnimalsCells
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Combined immune checkpoint blockade increases CD8+CD28+PD-1+ effector T cells and provides a therapeutic strategy for patients with neuroblastoma. Oncoimmunology. 2021 01 04; 10(1):1838140.
Shirinbak S, Chan RY, Shahani S, Muthugounder S, Kennedy R, Hung LT, Fernandez GE, Hadjidaniel MD, Moghimi B, Sheard MA, Epstein AL, Fabbri M, Shimada H, Asgharzadeh S. PMID: 33489468; PMCID: PMC7801125.
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PubMed Mentions:
20 Fields:
Translation:
HumansAnimalsCells
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Somatic structural variation targets neurodevelopmental genes and identifies SHANK2 as a tumor suppressor in neuroblastoma. Genome Res. 2020 09; 30(9):1228-1242.
Lopez G, Conkrite KL, Doepner M, Rathi KS, Modi A, Vaksman Z, Farra LM, Hyson E, Noureddine M, Wei JS, Smith MA, Asgharzadeh S, Seeger RC, Khan J, Auvil JG, Gerhard DS, Maris JM, Diskin SJ. PMID: 32796005; PMCID: PMC7545140.
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PubMed Mentions:
17 Fields:
Translation:
HumansCells
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Irinotecan, Temozolomide, and Dinutuximab With GM-CSF in Children With Refractory or Relapsed Neuroblastoma: A Report From the Children's Oncology Group. J Clin Oncol. 2020 07 01; 38(19):2160-2169.
Mody R, Yu AL, Naranjo A, Zhang FF, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Hank JA, Felder M, Birstler J, Sondel PM, Asgharzadeh S, Glade-Bender J, Katzenstein H, Maris JM, Park JR, Bagatell R. PMID: 32343642; PMCID: PMC7325366.
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PubMed Mentions:
58 Fields:
Translation:
HumansCTClinical Trials
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A genome-wide association study on medulloblastoma. J Neurooncol. 2020 Apr; 147(2):309-315.
Dahlin AM, Wibom C, Andersson U, Bybjerg-Grauholm J, Deltour I, Hougaard DM, Scheurer ME, Lau CC, McKean-Cowdin R, Kennedy RJ, Hung LT, Yee J, Margol AS, Barrington-Trimis J, Gauderman WJ, Feychting M, Schüz J, Röösli M, Kjaerheim K, Cefalo Study Group, Januszkiewicz-Lewandowska D, Fichna M, Nowak J, Searles Nielsen S, Asgharzadeh S, Mirabello L, Hjalmars U, Melin B. PMID: 32056145; PMCID: PMC7136185.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Multi-site reproducibility of a human immunophenotyping assay in whole blood and peripheral blood mononuclear cells preparations using CyTOF technology coupled with Maxpar Pathsetter, an automated data analysis system. Cytometry B Clin Cytom. 2020 03; 98(2):146-160.
Bagwell CB, Hunsberger B, Hill B, Herbert D, Bray C, Selvanantham T, Li S, Villasboas JC, Pavelko K, Strausbauch M, Rahman A, Kelly G, Asgharzadeh S, Gomez-Cabrero A, Behbehani G, Chang H, Lyberger J, Montgomery R, Zhao Y, Inokuma M, Goldberger O, Stelzer G. PMID: 31758746; PMCID: PMC7543682.
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PubMed Mentions:
24 Fields:
Translation:
HumansCells
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Prognostic significance of molecular subgroups of medulloblastoma in young children receiving irradiation-sparing regimens. J Neurooncol. 2019 Nov; 145(2):375-383.
Yeo KK, Margol AS, Kennedy RJ, Hung L, Robison NJ, Dhall G, Asgharzadeh S. PMID: 31621042; PMCID: PMC7543681.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Improvements to the Escalation with Overdose Control design and a comparison with the restricted Continual Reassessment Method. Pharm Stat. 2019 11; 18(6):659-670.
Ji L, Lewinger JP, Krailo M, Groshen S, Conti DV, Asgharzadeh S, Sposto R. PMID: 31237419; PMCID: PMC8932137.
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PubMed Mentions: Fields:
Translation:
Humans
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Enhancing Natural Killer and CD8+ T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8+ T Cells with HLA-E Monospecific Monoclonal Antibodies. Monoclon Antib Immunodiagn Immunother. 2019 Apr; 38(2):38-59.
Ravindranath MH, Filippone EJ, Devarajan A, Asgharzadeh S. PMID: 31009335; PMCID: PMC6634170.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Myc and Loss of p53 Cooperate to Drive Formation of Choroid Plexus Carcinoma. Cancer Res. 2019 05 01; 79(9):2208-2219.
Wang J, Merino DM, Light N, Murphy BL, Wang YD, Guo X, Hodges AP, Chau LQ, Liu KW, Dhall G, Asgharzadeh S, Kiehna EN, Shirey RJ, Janda KD, Taylor MD, Malkin D, Ellison DW, VandenBerg SR, Eberhart CG, Sears RC, Roussel MF, Gilbertson RJ, Wechsler-Reya RJ. PMID: 30885981; PMCID: PMC6497574.
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PubMed Mentions:
10 Fields:
Translation:
AnimalsCells
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Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients. J Natl Cancer Inst. 2018 10 01; 110(10):1084-1093.
Depuydt P, Boeva V, Hocking TD, Cannoodt R, Ambros IM, Ambros PF, Asgharzadeh S, Attiyeh EF, Combaret V, Defferrari R, Fischer M, Hero B, Hogarty MD, Irwin MS, Koster J, Kreissman S, Ladenstein R, Lapouble E, Laureys G, London WB, Mazzocco K, Nakagawara A, Noguera R, Ohira M, Park JR, Pötschger U, Theissen J, Tonini GP, Valteau-Couanet D, Varesio L, Versteeg R, Speleman F, Maris JM, Schleiermacher G, De Preter K. PMID: 29514301; PMCID: PMC6186524.
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PubMed Mentions:
48 Fields:
Translation:
HumansCells
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Clinically Relevant Cytotoxic Immune Cell Signatures and Clonal Expansion of T-Cell Receptors in High-Risk MYCN-Not-Amplified Human Neuroblastoma. Clin Cancer Res. 2018 11 15; 24(22):5673-5684.
Wei JS, Kuznetsov IB, Zhang S, Song YK, Asgharzadeh S, Sindiri S, Wen X, Patidar R, Najaraj S, Walton A, Auvil JMG, Gerhard DS, Yuksel A, Catchpoole D, Hewitt SM, Sondel PM, Seeger R, Maris JM, Khan J. PMID: 29784674; PMCID: PMC6504934.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma. Cancer Discov. 2018 05; 8(5):582-599.
Rajbhandari P, Lopez G, Capdevila C, Salvatori B, Yu J, Rodriguez-Barrueco R, Martinez D, Yarmarkovich M, Weichert-Leahey N, Abraham BJ, Alvarez MJ, Iyer A, Harenza JL, Oldridge D, De Preter K, Koster J, Asgharzadeh S, Seeger RC, Wei JS, Khan J, Vandesompele J, Mestdagh P, Versteeg R, Look AT, Young RA, Iavarone A, Lasorella A, Silva JM, Maris JM, Califano A. PMID: 29510988; PMCID: PMC5967627.
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PubMed Mentions:
78 Fields:
Translation:
HumansCells
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Rare MYC-amplified Neuroblastoma With Large Cell Histology. Pediatr Dev Pathol. 2018 Sep-Oct; 21(5):461-466.
Matsuno R, Gifford AJ, Fang J, Warren M, Lukeis RE, Trahair T, Sugimoto T, Marachelian A, Asgharzadeh S, Maris JM, Ikegaki N, Shimada H. PMID: 29426276; PMCID: PMC7469889.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group. Oncotarget. 2018 Jan 19; 9(5):6416-6432.
Niemas-Teshiba R, Matsuno R, Wang LL, Tang XX, Chiu B, Zeki J, Coburn J, Ornell K, Naranjo A, Van Ryn C, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Asgharzadeh S, Ikegaki N, Shimada H. PMID: 29464082; PMCID: PMC5814222.
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PubMed Mentions:
17 Fields:
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Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC. Oncotarget. 2017 Oct 31; 8(53):91516-91529.
Hadjidaniel MD, Muthugounder S, Hung LT, Sheard MA, Shirinbak S, Chan RY, Nakata R, Borriello L, Malvar J, Kennedy RJ, Iwakura H, Akamizu T, Sposto R, Shimada H, DeClerck YA, Asgharzadeh S. PMID: 29207662; PMCID: PMC5710942.
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PubMed Mentions:
38 Fields:
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NK Cell-derived Exosomes From NK Cells Previously Exposed to Neuroblastoma Cells Augment the Antitumor Activity of Cytokine-activated NK Cells. J Immunother. 2017 09; 40(7):265-276.
Shoae-Hassani A, Hamidieh AA, Behfar M, Mohseni R, Mortazavi-Tabatabaei SA, Asgharzadeh S. PMID: 28622272; PMCID: PMC7543683.
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PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells. Cancer Res. 2017 09 15; 77(18):5142-5157.
Borriello L, Nakata R, Sheard MA, Fernandez GE, Sposto R, Malvar J, Blavier L, Shimada H, Asgharzadeh S, Seeger RC, DeClerck YA. PMID: 28687621; PMCID: PMC5600847.
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PubMed Mentions:
103 Fields:
Translation:
HumansAnimalsCells
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Expression of Five Neuroblastoma Genes in Bone Marrow or Blood of Patients with Relapsed/Refractory Neuroblastoma Provides a New Biomarker for Disease and Prognosis. Clin Cancer Res. 2017 Sep 15; 23(18):5374-5383.
Marachelian A, Villablanca JG, Liu CW, Liu B, Goodarzian F, Lai HA, Shimada H, Tran HC, Parra JA, Gallego R, Bedrossian N, Young S, Czarnecki S, Kennedy R, Weiss BD, Goldsmith K, Granger M, Matthay KK, Groshen S, Asgharzadeh S, Sposto R, Seeger RC. PMID: 28559462.
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PubMed Mentions:
31 Fields:
Translation:
Humans
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TGFβR1 Blockade with Galunisertib (LY2157299) Enhances Anti-Neuroblastoma Activity of the Anti-GD2 Antibody Dinutuximab (ch14.18) with Natural Killer Cells. Clin Cancer Res. 2017 Feb 01; 23(3):804-813.
Tran HC, Wan Z, Sheard MA, Sun J, Jackson JR, Malvar J, Xu Y, Wang L, Sposto R, Kim ES, Asgharzadeh S, Seeger RC. PMID: 27756784; PMCID: PMC5361893.
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PubMed Mentions:
80 Fields:
Translation:
HumansAnimalsCells
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BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907.
Shackleford GM, Shi XH, Swanson KS, Mahdi MY, Gonzalez-Gomez I, Asgharzadeh S, D'Apuzzo M, Erdreich-Epstein A, Moats RA. PMID: 27310018; PMCID: PMC4911170.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma. Cancer Lett. 2016 Feb 28; 371(2):214-24.
Zhang S, Wei JS, Li SQ, Badgett TC, Song YK, Agarwal S, Coarfa C, Tolman C, Hurd L, Liao H, He J, Wen X, Liu Z, Thiele CJ, Westermann F, Asgharzadeh S, Seeger RC, Maris JM, Guidry Auvil JM, Smith MA, Kolaczyk ED, Shohet J, Khan J. PMID: 26683771; PMCID: PMC4738031.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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More than the genes, the tumor microenvironment in neuroblastoma. Cancer Lett. 2016 09 28; 380(1):304-14.
Borriello L, Seeger RC, Asgharzadeh S, DeClerck YA. PMID: 26597947; PMCID: PMC5558454.
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PubMed Mentions:
45 Fields:
Translation:
HumansAnimalsCells
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A LIN28B-RAN-AURKA Signaling Network Promotes Neuroblastoma Tumorigenesis. Cancer Cell. 2015 Nov 09; 28(5):599-609.
Schnepp RW, Khurana P, Attiyeh EF, Raman P, Chodosh SE, Oldridge DA, Gagliardi ME, Conkrite KL, Asgharzadeh S, Seeger RC, Madison BB, Rustgi AK, Maris JM, Diskin SJ. PMID: 26481147; PMCID: PMC4643330.
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PubMed Mentions:
68 Fields:
Translation:
HumansCells
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Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015; 5:191.
Xu J, Margol AS, Shukla A, Ren X, Finlay JL, Krieger MD, Gilles FH, Couch FJ, Aziz M, Fung ET, Asgharzadeh S, Barrett MT, Erdreich-Epstein A. PMID: 26380221; PMCID: PMC4550790.
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PubMed Mentions:
10
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Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol. 2016 Jan; 18(1):126-31.
Blüml S, Margol AS, Sposto R, Kennedy RJ, Robison NJ, Vali M, Hung LT, Muthugounder S, Finlay JL, Erdreich-Epstein A, Gilles FH, Judkins AR, Krieger MD, Dhall G, Nelson MD, Asgharzadeh S. PMID: 26254476; PMCID: PMC4677409.
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PubMed Mentions:
34 Fields:
Translation:
Humans
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Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations. Nat Genet. 2015 08; 47(8):864-71.
Eleveld TF, Oldridge DA, Bernard V, Koster J, Colmet Daage L, Diskin SJ, Schild L, Bentahar NB, Bellini A, Chicard M, Lapouble E, Combaret V, Legoix-Né P, Michon J, Pugh TJ, Hart LS, Rader J, Attiyeh EF, Wei JS, Zhang S, Naranjo A, Gastier-Foster JM, Hogarty MD, Asgharzadeh S, Smith MA, Guidry Auvil JM, Watkins TB, Zwijnenburg DA, Ebus ME, van Sluis P, Hakkert A, van Wezel E, van der Schoot CE, Westerhout EM, Schulte JH, Tytgat GA, Dolman ME, Janoueix-Lerosey I, Gerhard DS, Caron HN, Delattre O, Khan J, Versteeg R, Schleiermacher G, Molenaar JJ, Maris JM. PMID: 26121087; PMCID: PMC4775079.
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PubMed Mentions:
272 Fields:
Translation:
HumansAnimalsCells
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Comparison of RNA-seq and microarray-based models for clinical endpoint prediction. Genome Biol. 2015 Jun 25; 16:133.
Zhang W, Yu Y, Hertwig F, Thierry-Mieg J, Zhang W, Thierry-Mieg D, Wang J, Furlanello C, Devanarayan V, Cheng J, Deng Y, Hero B, Hong H, Jia M, Li L, Lin SM, Nikolsky Y, Oberthuer A, Qing T, Su Z, Volland R, Wang C, Wang MD, Ai J, Albanese D, Asgharzadeh S, Avigad S, Bao W, Bessarabova M, Brilliant MH, Brors B, Chierici M, Chu TM, Zhang J, Grundy RG, He MM, Hebbring S, Kaufman HL, Lababidi S, Lancashire LJ, Li Y, Lu XX, Luo H, Ma X, Ning B, Noguera R, Peifer M, Phan JH, Roels F, Rosswog C, Shao S, Shen J, Theissen J, Tonini GP, Vandesompele J, Wu PY, Xiao W, Xu J, Xu W, Xuan J, Yang Y, Ye Z, Dong Z, Zhang KK, Yin Y, Zhao C, Zheng Y, Wolfinger RD, Shi T, Malkas LH, Berthold F, Wang J, Tong W, Shi L, Peng Z, Fischer M. PMID: 26109056; PMCID: PMC4506430.
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PubMed Mentions:
210 Fields:
Translation:
HumansCells
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CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. Cancer Res. 2015 Aug 01; 75(15):3155-66.
Russell MR, Penikis A, Oldridge DA, Alvarez-Dominguez JR, McDaniel L, Diamond M, Padovan O, Raman P, Li Y, Wei JS, Zhang S, Gnanchandran J, Seeger R, Asgharzadeh S, Khan J, Diskin SJ, Maris JM, Cole KA. PMID: 26100672; PMCID: PMC4526355.
View in:
PubMed Mentions:
101 Fields:
Translation:
HumansCells
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Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study. Br J Cancer. 2015 Jun 30; 113(1):57-63.
Wang LL, Teshiba R, Ikegaki N, Tang XX, Naranjo A, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Asgharzadeh S, Shimada H. PMID: 26035700; PMCID: PMC4647535.
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PubMed Mentions:
62 Fields:
Translation:
Humans
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Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy. J Natl Cancer Inst. 2015 Jul; 107(7).
Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. PMID: 25972604; PMCID: PMC4651042.
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PubMed Mentions:
194 Fields:
Translation:
HumansCells
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Preservation of high glycolytic phenotype by establishing new acute lymphoblastic leukemia cell lines at physiologic oxygen concentration. Exp Cell Res. 2015 May 15; 334(1):78-89.
Sheard MA, Ghent MV, Cabral DJ, Lee JC, Khankaldyyan V, Ji L, Wu SQ, Kang MH, Sposto R, Asgharzadeh S, Reynolds CP. PMID: 25845499; PMCID: PMC8219348.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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View in:
PubMed Mentions:
31 Fields:
Translation:
HumansCells
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Tumor-associated macrophages in SHH subgroup of medulloblastomas. Clin Cancer Res. 2015 Mar 15; 21(6):1457-65.
Margol AS, Robison NJ, Gnanachandran J, Hung LT, Kennedy RJ, Vali M, Dhall G, Finlay JL, Erdreich-Epstein A, Krieger MD, Drissi R, Fouladi M, Gilles FH, Judkins AR, Sposto R, Asgharzadeh S. PMID: 25344580; PMCID: PMC7654723.
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PubMed Mentions:
63 Fields:
Translation:
HumansCells
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Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling. PLoS One. 2014; 9(10):e108818.
Lee S, Rahnenführer J, Lang M, De Preter K, Mestdagh P, Koster J, Versteeg R, Stallings RL, Varesio L, Asgharzadeh S, Schulte JH, Fielitz K, Schwermer M, Morik K, Schramm A. PMID: 25295525; PMCID: PMC4190101.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Revised risk estimation and treatment stratification of low- and intermediate-risk neuroblastoma patients by integrating clinical and molecular prognostic markers. Clin Cancer Res. 2015 Apr 15; 21(8):1904-15.
Oberthuer A, Juraeva D, Hero B, Volland R, Sterz C, Schmidt R, Faldum A, Kahlert Y, Engesser A, Asgharzadeh S, Seeger R, Ohira M, Nakagawara A, Scaruffi P, Tonini GP, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Speleman F, Noguera R, Piqueras M, Bénard J, Valent A, Avigad S, Yaniv I, Grundy RG, Ortmann M, Shao C, Schwab M, Eils R, Simon T, Theissen J, Berthold F, Westermann F, Brors B, Fischer M. PMID: 25231397.
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PubMed Mentions:
42 Fields:
Translation:
Humans
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MYCN-dependent expression of sulfatase-2 regulates neuroblastoma cell survival. Cancer Res. 2014 Nov 01; 74(21):5999-6009.
Solari V, Borriello L, Turcatel G, Shimada H, Sposto R, Fernandez GE, Asgharzadeh S, Yates EA, Turnbull JE, DeClerck YA. PMID: 25164011; PMCID: PMC4216758.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Clin Cancer Res. 2014 Feb 15; 20(4):827-36.
Erdreich-Epstein A, Robison N, Ren X, Zhou H, Xu J, Davidson TB, Schur M, Gilles FH, Ji L, Malvar J, Shackleford GM, Margol AS, Krieger MD, Judkins AR, Jones DT, Pfister SM, Kool M, Sposto R, Asgharzadeh S, Asgharazadeh S. PMID: 24300787; PMCID: PMC3962776.
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PubMed Mentions:
19 Fields:
Translation:
HumansCells
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Lenalidomide overcomes suppression of human natural killer cell anti-tumor functions by neuroblastoma microenvironment-associated IL-6 and TGFβ1. Cancer Immunol Immunother. 2013 Oct; 62(10):1637-48.
Xu Y, Sun J, Sheard MA, Tran HC, Wan Z, Liu WY, Asgharzadeh S, Sposto R, Wu HW, Seeger RC. PMID: 23982484; PMCID: PMC3907789.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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View in:
PubMed Mentions:
34 Fields:
Translation:
Humans
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Medulloblastoma expresses CD1d and can be targeted for immunotherapy with NKT cells. Clin Immunol. 2013 Oct; 149(1):55-64.
Liu D, Song L, Brawley VS, Robison N, Wei J, Gao X, Tian G, Margol A, Ahmed N, Asgharzadeh S, Metelitsa LS. PMID: 23891738; PMCID: PMC3809126.
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PubMed Mentions:
40 Fields:
Translation:
HumansAnimalsCells
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Membrane-bound TRAIL supplements natural killer cell cytotoxicity against neuroblastoma cells. J Immunother. 2013 Jun; 36(5):319-29.
Sheard MA, Asgharzadeh S, Liu Y, Lin TY, Wu HW, Ji L, Groshen S, Lee DA, Seeger RC. PMID: 23719242; PMCID: PMC4064791.
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PubMed Mentions:
29 Fields:
Translation:
HumansCells
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The genetic landscape of high-risk neuroblastoma. Nat Genet. 2013 Mar; 45(3):279-84.
Pugh TJ, Morozova O, Attiyeh EF, Asgharzadeh S, Wei JS, Auclair D, Carter SL, Cibulskis K, Hanna M, Kiezun A, Kim J, Lawrence MS, Lichenstein L, McKenna A, Pedamallu CS, Ramos AH, Shefler E, Sivachenko A, Sougnez C, Stewart C, Ally A, Birol I, Chiu R, Corbett RD, Hirst M, Jackman SD, Kamoh B, Khodabakshi AH, Krzywinski M, Lo A, Moore RA, Mungall KL, Qian J, Tam A, Thiessen N, Zhao Y, Cole KA, Diamond M, Diskin SJ, Mosse YP, Wood AC, Ji L, Sposto R, Badgett T, London WB, Moyer Y, Gastier-Foster JM, Smith MA, Guidry Auvil JM, Gerhard DS, Hogarty MD, Jones SJ, Lander ES, Gabriel SB, Getz G, Seeger RC, Khan J, Marra MA, Meyerson M, Maris JM. PMID: 23334666; PMCID: PMC3682833.
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PubMed Mentions:
614 Fields:
Translation:
HumansCells
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Copy number variation signature to predict human ancestry. BMC Bioinformatics. 2012 Dec 27; 13:336.
Pronold M, Vali M, Pique-Regi R, Asgharzadeh S. PMID: 23270563; PMCID: PMC3598683.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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TARGETgene: a tool for identification of potential therapeutic targets in cancer. PLoS One. 2012; 7(8):e43305.
Wu CC, D'Argenio D, Asgharzadeh S, Triche T. PMID: 22952662; PMCID: PMC3432038.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Clinical significance of tumor-associated inflammatory cells in metastatic neuroblastoma. J Clin Oncol. 2012 Oct 01; 30(28):3525-32.
Asgharzadeh S, Salo JA, Ji L, Oberthuer A, Fischer M, Berthold F, Hadjidaniel M, Liu CW, Metelitsa LS, Pique-Regi R, Wakamatsu P, Villablanca JG, Kreissman SG, Matthay KK, Shimada H, London WB, Sposto R, Seeger RC. PMID: 22927533; PMCID: PMC3675667.
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PubMed Mentions:
161 Fields:
Translation:
HumansCells
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IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity. J Clin Invest. 2012 Jun; 122(6):2221-33.
Liu D, Song L, Wei J, Courtney AN, Gao X, Marinova E, Guo L, Heczey A, Asgharzadeh S, Kim E, Dotti G, Metelitsa LS. PMID: 22565311; PMCID: PMC3366399.
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Novel pathways to erythropoiesis induced by dimerization of intracellular C-Mpl in human hematopoietic progenitors. Stem Cells. 2012 Apr; 30(4):697-708.
Parekh C, Sahaghian A, Kim W, Scholes J, Ge S, Zhu Y, Asgharzadeh S, Hollis R, Kohn D, Ji L, Malvar J, Wang X, Crooks G. PMID: 22290824; PMCID: PMC3973153.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. Cancer Res. 2012 Apr 15; 72(8):2068-78.
Bosse KR, Diskin SJ, Cole KA, Wood AC, Schnepp RW, Norris G, Nguyen le B, Jagannathan J, Laquaglia M, Winter C, Diamond M, Hou C, Attiyeh EF, Mosse YP, Pineros V, Dizin E, Zhang Y, Asgharzadeh S, Seeger RC, Capasso M, Pawel BR, Devoto M, Hakonarson H, Rappaport EF, Irminger-Finger I, Maris JM. PMID: 22350409; PMCID: PMC3328617.
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PubMed Mentions:
62 Fields:
Translation:
HumansAnimalsCells
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Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 2012 Nov 15; 31(46):4859-67.
Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Vigny M, Mazot P, Asgharzadeh S, Seeger RC, Zhao H, Guo R, Christensen JG, Orange JS, Pawel BR, Lemmon MA, Mossé YP. PMID: 22266870; PMCID: PMC3730824.
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PubMed Mentions:
33 Fields:
Translation:
HumansCells
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Neuroblastoma: issues in transplantation. Biol Blood Marrow Transplant. 2012 Jan; 18(1 Suppl):S92-100.
Grupp SA, Asgharzadeh S, Yanik GA. PMID: 22226119; PMCID: PMC3260463.
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PubMed Mentions:
5 Fields:
Translation:
Humans
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Bioinformatics for copy number variation data. Methods Mol Biol. 2011; 719:235-49.
Warden M, Pique-Regi R, Ortega A, Asgharzadeh S. PMID: 21370087.
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PubMed Mentions:
2 Fields:
Translation:
Humans
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NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome. Cell. 2010 Jul 23; 142(2):218-29.
Hölzel M, Huang S, Koster J, Ora I, Lakeman A, Caron H, Nijkamp W, Xie J, Callens T, Asgharzadeh S, Seeger RC, Messiaen L, Versteeg R, Bernards R. PMID: 20655465; PMCID: PMC2913027.
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PubMed Mentions:
99 Fields:
Translation:
HumansCells
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Prognostic impact of gene expression-based classification for neuroblastoma. J Clin Oncol. 2010 Jul 20; 28(21):3506-15.
Oberthuer A, Hero B, Berthold F, Juraeva D, Faldum A, Kahlert Y, Asgharzadeh S, Seeger R, Scaruffi P, Tonini GP, Janoueix-Lerosey I, Delattre O, Schleiermacher G, Vandesompele J, Vermeulen J, Speleman F, Noguera R, Piqueras M, Bénard J, Valent A, Avigad S, Yaniv I, Weber A, Christiansen H, Grundy RG, Schardt K, Schwab M, Eils R, Warnat P, Kaderali L, Simon T, Decarolis B, Theissen J, Westermann F, Brors B, Fischer M. PMID: 20567016.
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PubMed Mentions:
55 Fields:
Translation:
Humans
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Prediction of human functional genetic networks from heterogeneous data using RVM-based ensemble learning. Bioinformatics. 2010 Mar 15; 26(6):807-13.
Wu CC, Asgharzadeh S, Triche TJ, D'Argenio DZ. PMID: 20134029; PMCID: PMC2832827.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages. J Clin Invest. 2009 Jun; 119(6):1524-36.
Song L, Asgharzadeh S, Salo J, Engell K, Wu HW, Sposto R, Ara T, Silverman AM, DeClerck YA, Seeger RC, Metelitsa LS. PMID: 19411762; PMCID: PMC2689106.
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PubMed Mentions:
168 Fields:
Translation:
HumansAnimalsCells
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Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. Nat Genet. 2009 Jun; 41(6):718-23.
Capasso M, Devoto M, Hou C, Asgharzadeh S, Glessner JT, Attiyeh EF, Mosse YP, Kim C, Diskin SJ, Cole KA, Bosse K, Diamond M, Laudenslager M, Winter C, Bradfield JP, Scott RH, Jagannathan J, Garris M, McConville C, London WB, Seeger RC, Grant SF, Li H, Rahman N, Rappaport E, Hakonarson H, Maris JM. PMID: 19412175; PMCID: PMC2753610.
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PubMed Mentions:
169 Fields:
Translation:
HumansCells
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ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell. 2009 Apr 07; 15(4):328-40.
Huang S, Laoukili J, Epping MT, Koster J, Hölzel M, Westerman BA, Nijkamp W, Hata A, Asgharzadeh S, Seeger RC, Versteeg R, Beijersbergen RL, Bernards R. PMID: 19345331; PMCID: PMC2693316.
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PubMed Mentions:
85 Fields:
Translation:
HumansCells
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Joint estimation of copy number variation and reference intensities on multiple DNA arrays using GADA. Bioinformatics. 2009 May 15; 25(10):1223-30.
Pique-Regi R, Ortega A, Asgharzadeh S. PMID: 19276152; PMCID: PMC2732310.
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PubMed Mentions:
18 Fields:
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Intensive induction chemotherapy followed by high dose chemotherapy with autologous hematopoietic progenitor cell rescue in young children newly diagnosed with central nervous system atypical teratoid rhabdoid tumors. Pediatr Blood Cancer. 2008 Aug; 51(2):235-40.
Gardner SL, Asgharzadeh S, Green A, Horn B, McCowage G, Finlay J. PMID: 18381756.
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PubMed Mentions:
54 Fields:
Translation:
Humans
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An integrated cross-platform prognosis study on neuroblastoma patients. Genomics. 2008 Oct; 92(4):195-203.
Chen QR, Song YK, Wei JS, Bilke S, Asgharzadeh S, Seeger RC, Khan J. PMID: 18598751; PMCID: PMC2562635.
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PubMed Mentions:
32 Fields:
Translation:
Humans
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Chromosome 6p22 locus associated with clinically aggressive neuroblastoma. N Engl J Med. 2008 Jun 12; 358(24):2585-93.
Maris JM, Mosse YP, Bradfield JP, Hou C, Monni S, Scott RH, Asgharzadeh S, Attiyeh EF, Diskin SJ, Laudenslager M, Winter C, Cole KA, Glessner JT, Kim C, Frackelton EC, Casalunovo T, Eckert AW, Capasso M, Rappaport EF, McConville C, London WB, Seeger RC, Rahman N, Devoto M, Grant SF, Li H, Hakonarson H. PMID: 18463370; PMCID: PMC2742373.
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PubMed Mentions:
157 Fields:
Translation:
HumansCells
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Intensive chemotherapy followed by consolidative myeloablative chemotherapy with autologous hematopoietic cell rescue (AuHCR) in young children with newly diagnosed supratentorial primitive neuroectodermal tumors (sPNETs): report of the Head Start I and II experience. Pediatr Blood Cancer. 2008 Feb; 50(2):312-8.
Fangusaro J, Finlay J, Sposto R, Ji L, Saly M, Zacharoulis S, Asgharzadeh S, Abromowitch M, Olshefski R, Halpern S, Dubowy R, Comito M, Diez B, Kellie S, Hukin J, Rosenblum M, Dunkel I, Miller DC, Allen J, Gardner S. PMID: 17668858.
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PubMed Mentions:
48 Fields:
Translation:
HumansCTClinical Trials
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Sparse representation and Bayesian detection of genome copy number alterations from microarray data. Bioinformatics. 2008 Feb 01; 24(3):309-18.
Pique-Regi R, Monso-Varona J, Ortega A, Seeger RC, Triche TJ, Asgharzadeh S. PMID: 18203770; PMCID: PMC2704547.
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PubMed Mentions:
62 Fields:
Translation:
Humans
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Outcome for young children newly diagnosed with ependymoma, treated with intensive induction chemotherapy followed by myeloablative chemotherapy and autologous stem cell rescue. Pediatr Blood Cancer. 2007 Jul; 49(1):34-40.
Zacharoulis S, Levy A, Chi SN, Gardner S, Rosenblum M, Miller DC, Dunkel I, Diez B, Sposto R, Ji L, Asgharzadeh S, Hukin J, Belasco J, Dubowy R, Kellie S, Termuhlen A, Finlay J. PMID: 16874765.
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PubMed Mentions:
37 Fields:
Translation:
Humans
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Prognostic significance of gene expression profiles of metastatic neuroblastomas lacking MYCN gene amplification. J Natl Cancer Inst. 2006 Sep 06; 98(17):1193-203.
Asgharzadeh S, Pique-Regi R, Sposto R, Wang H, Yang Y, Shimada H, Matthay K, Buckley J, Ortega A, Seeger RC. PMID: 16954472.
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PubMed Mentions:
126 Fields:
Translation:
Humans
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Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2. J Exp Med. 2004 May 03; 199(9):1213-21.
Metelitsa LS, Wu HW, Wang H, Yang Y, Warsi Z, Asgharzadeh S, Groshen S, Wilson SB, Seeger RC. PMID: 15123743; PMCID: PMC2211904.
View in:
PubMed Mentions:
119 Fields:
Translation:
HumansCells