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Anat Erdreich-Epstein, MD, PhD

Title(s)Associate Professor of Pediatrics
AddressCHL Mail Stop 57
Off Campus
Los Angeles CA 90089
Phone+1 323 361 4613
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Reciprocal Induction of MDM2 and MYCN in Neural and Neuroendocrine Cancers. Front Oncol. 2020; 10:563156. Tran HN, Singh HP, Guo W, Cambier L, Riggan L, Shackleford GM, Thornton ME, Grubbs BH, Erdreich-Epstein A, Qi DL, Cobrinik D. PMID: 33425720.
      View in: PubMed   Mentions:
    2. SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors. J Pathol. 2020 Sep; 252(1):77-87. Xue Y, Zhu X, Meehan B, Venneti S, Martinez D, Morin G, Maïga RI, Chen H, Papadakis AI, Johnson RM, O'Sullivan MJ, Erdreich-Epstein A, Gotlieb WH, Park M, Judkins AR, Pelletier J, Foulkes WD, Rak J, Huang S. PMID: 32558936.
      View in: PubMed   Mentions:    Fields:    
    3. GRK2 promotes growth of medulloblastoma cells and protects them from chemotherapy-induced apoptosis. Sci Rep. 2019 09 25; 9(1):13902. Pathania AS, Ren X, Mahdi MY, Shackleford GM, Erdreich-Epstein A. PMID: 31554835.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Rare Pediatric Invasive Gliofibroma Has BRAFV600E Mutation and Transiently Responds to Targeted Therapy Before Progressive Clonal Evolution. JCO Precis Oncol. 2019; 3. Kaneva K, Yeo KK, Hawes D, Ji J, Biegel JA, Nelson MD, Bluml S, Krieger MD, Erdreich-Epstein A. PMID: 31179415.
      View in: PubMed   Mentions:
    5. Continuous and bolus intraventricular topotecan prolong survival in a mouse model of leptomeningeal medulloblastoma. PLoS One. 2019; 14(1):e0206394. Shackleford GM, Mahdi MY, Moats RA, Hawes D, Tran HC, Finlay JL, Hoang TQ, Meng EF, Erdreich-Epstein A. PMID: 30608927.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NF?B. Sci Rep. 2017 04 11; 7(1):835. Xu J, Ren X, Pathania AS, Fernandez GE, Tran A, Zhang Y, Moats RA, Shackleford GM, Erdreich-Epstein A. PMID: 28400607.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study. Oncotarget. 2016 12 13; 7(50):83701-83719. PMID: 27863376.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    8. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors. Cancer Cell. 2016 Dec 12; 30(6):891-908. PMID: 27960086.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    9. Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2017 Aug 08; 8(32):52193-52210. PMID: 28881723.
      View in: PubMed   Mentions: 5     Fields:    
    10. Association of high microvessel avß3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126. Oncotarget. 2016 Nov 16. Erdreich-Epstein A, Singh AR, Joshi S, Vega FM, Guo P, Xu J, Groshen S, Ye W, Millard M, Campan M, Morales G, Garlich JR, Laird PW, Seeger RC, Shimada H, Durden DL. PMID: 27907905.
      View in: PubMed   Mentions:
    11. BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907. PMID: 27310018.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    12. Re-irradiation of Recurrent Pineal Germ Cell Tumors with Radiosurgery: Report of Two Cases and Review of Literature. Cureus. 2016 Apr 25; 8(4):e585. PMID: 27239400.
      View in: PubMed   Mentions:
    13. Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia. Front Oncol. 2015; 5:191. PMID: 26380221.
      View in: PubMed   Mentions:
    14. Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy. Neuro Oncol. 2016 Jan; 18(1):126-31. PMID: 26254476.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    15. Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target. Oncotarget. 2015 Feb 20; 6(5):3165-77. PMID: 25638158.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. The chromatin-modifying protein HMGA2 promotes atypical teratoid/rhabdoid cell tumorigenicity. J Neuropathol Exp Neurol. 2015 Feb; 74(2):177-85. PMID: 25575139.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    17. Pediatric brain tumor cell lines. J Cell Biochem. 2015 Feb; 116(2):218-24. PMID: 25211508.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    18. Tumor-associated macrophages in SHH subgroup of medulloblastomas. Clin Cancer Res. 2015 Mar 15; 21(6):1457-65. PMID: 25344580.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    19. Wnt pathway in atypical teratoid rhabdoid tumors. Neuro Oncol. 2015 Apr; 17(4):526-35. PMID: 25246426.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    20. Novel paracrine modulation of Notch-DLL4 signaling by fibulin-3 promotes angiogenesis in high-grade gliomas. Cancer Res. 2014 Oct 01; 74(19):5435-5448. PMID: 25139440.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    21. A retrospective analysis of recurrent intracranial ependymoma. Pediatr Blood Cancer. 2014 Jul; 61(7):1195-201. PMID: 24615997.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCTClinical Trials
    22. A novel tumor-promoting role for nuclear factor IA in glioblastomas is mediated through negative regulation of p53, p21, and PAI1. Neuro Oncol. 2014 Jan; 16(2):191-203. PMID: 24305710.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    23. PID1 (NYGGF4), a new growth-inhibitory gene in embryonal brain tumors and gliomas. Clin Cancer Res. 2014 Feb 15; 20(4):827-36. PMID: 24300787.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    24. c-Abl is an upstream regulator of acid sphingomyelinase in apoptosis induced by inhibition of integrins avß3 and avß5. PLoS One. 2012; 7(8):e42291. PMID: 22879933.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    25. Heparanase-induced GEF-H1 signaling regulates the cytoskeletal dynamics of brain metastatic breast cancer cells. Mol Cancer Res. 2012 Jun; 10(6):689-702. PMID: 22513363.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    26. Microdeletion del(22)(q12.2) encompassing the facial development-associated gene, MN1 (meningioma 1) in a child with Pierre-Robin sequence (including cleft palate) and neurofibromatosis 2 (NF2): a case report and review of the literature. BMC Med Genet. 2012 Mar 22; 13:19. PMID: 22436304.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    27. Novel cell lines established from pediatric brain tumors. J Neurooncol. 2012 Apr; 107(2):269-80. PMID: 22120608.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    28. Gliovascular and cytokine interactions modulate brain endothelial barrier in vitro. J Neuroinflammation. 2011 Nov 23; 8:162. PMID: 22112345.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    29. Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: the Children's Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer. 2012 Jun; 58(6):905-9. PMID: 21990040.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    30. Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimen. J Neurooncol. 2011 Jul; 103(3):673-80. Parekh C, Jubran R, Erdreich-Epstein A, Panigrahy A, Bluml S, Finlay J, Dhall G. PMID: 21038110.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    31. Novel cancer vaccine based on genes of Salmonella pathogenicity island 2. Int J Cancer. 2010 Jun 01; 126(11):2622-34. Xiong G, Husseiny MI, Song L, Erdreich-Epstein A, Shackleford GM, Seeger RC, Jäckel D, Hensel M, Metelitsa LS. PMID: 19824039.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. c-Abl mediates endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 and by disruption of actin. Blood. 2010 Apr 01; 115(13):2709-18. Xu J, Millard M, Ren X, Cox OT, Erdreich-Epstein A. PMID: 20124512.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    33. Nuclear factor IA is expressed in astrocytomas and is associated with improved survival. Neuro Oncol. 2010 Feb; 12(2):122-32. Song HR, Gonzalez-Gomez I, Suh GS, Commins DL, Sposto R, Gilles FH, Deneen B, Erdreich-Epstein A. PMID: 20150379.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    34. Metabolism of orthotopic mouse brain tumor models. Mol Imaging. 2009 Jul-Aug; 8(4):199-208. Rosol M, Harutyunyan I, Xu J, Melendez E, Smbatyan G, Finlay JL, Krieger MD, Gonzalez-Gomez I, Reynolds CP, Nelson MD, Erdreich-Epstein A, Blüml S. PMID: 19728974.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    35. High-dose chemotherapy and autologous hematopoietic progenitor cell rescue in children with recurrent medulloblastoma and supratentorial primitive neuroectodermal tumors: the impact of prior radiotherapy on outcome. Cancer. 2009 Jul 01; 115(13):2956-63. Butturini AM, Jacob M, Aguajo J, Vander-Walde NA, Villablanca J, Jubran R, Erdreich-Epstein A, Marachelian A, Dhall G, Finlay JL. PMID: 19402050.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    36. Progress in the treatment of childhood brain tumors: no room for complacency. Pediatr Hematol Oncol. 2007 Jan-Feb; 24(1):79-84. Finlay JL, Erdreich-Epstein A, Packer RJ. PMID: 17130118.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    37. Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis. Brain Behav Immun. 2007 May; 21(4):395-408. Rosenne E, Shakhar G, Melamed R, Schwartz Y, Erdreich-Epstein A, Ben-Eliyahu S. PMID: 17240115.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    38. Androgen inducibility of Fgf8 in Shionogi carcinoma 115 cells correlates with an adjacent t(5;19) translocation. Genes Chromosomes Cancer. 2006 Feb; 45(2):169-81. Erdreich-Epstein A, Ganguly AK, Shi XH, Zimonjic DB, Shackleford GM. PMID: 16252261.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    39. Bone marrow mesenchymal stem cells provide an alternate pathway of osteoclast activation and bone destruction by cancer cells. Cancer Res. 2005 Feb 15; 65(4):1129-35. Sohara Y, Shimada H, Minkin C, Erdreich-Epstein A, Nolta JA, DeClerck YA. PMID: 15734993.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    40. Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood. 2005 Jun 01; 105(11):4353-61. Erdreich-Epstein A, Tran LB, Cox OT, Huang EY, Laug WE, Shimada H, Millard M. PMID: 15705795.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    41. Approaches to treatment for extraocular retinoblastoma: Children's Hospital Los Angeles experience. J Pediatr Hematol Oncol. 2004 Jan; 26(1):31-4. Jubran RF, Erdreich-Epstein A, Butturini A, Murphree AL, Villablanca JG. PMID: 14707710.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    42. Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors. Lab Invest. 2003 Dec; 83(12):1787-98. Stins MF, Pearce D, Di Cello F, Erdreich-Epstein A, Pardo CA, Sik Kim K. PMID: 14691297.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    43. Placenta growth factor activates monocytes and correlates with sickle cell disease severity. Blood. 2003 Aug 15; 102(4):1506-14. Perelman N, Selvaraj SK, Batra S, Luck LR, Erdreich-Epstein A, Coates TD, Kalra VK, Malik P. PMID: 12714517.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCells
    44. Ceramide signaling in fenretinide-induced endothelial cell apoptosis. J Biol Chem. 2002 Dec 20; 277(51):49531-7. Erdreich-Epstein A, Tran LB, Bowman NN, Wang H, Cabot MC, Durden DL, Vlckova J, Reynolds CP, Stins MF, Groshen S, Millard M. PMID: 12388538.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    45. Successful multimodality therapy of recurrent multifocal juvenile granulosa cell tumor of the ovary. J Pediatr Hematol Oncol. 2002 Mar-Apr; 24(3):229-33. Erdreich-Epstein A, Monforte HL, Lavey RS, Joshi S, Phillips JD, Villablanca JG. PMID: 11990313.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    46. Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res. 2001 Jul 15; 61(14):5587-94. Isogai C, Laug WE, Shimada H, Declerck PJ, Stins MF, Durden DL, Erdreich-Epstein A, DeClerck YA. PMID: 11454712.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    47. Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide. Cancer Res. 2000 Feb 01; 60(3):712-21. Erdreich-Epstein A, Shimada H, Groshen S, Liu M, Metelitsa LS, Kim KS, Stins MF, Seeger RC, Durden DL. PMID: 10676658.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansCells
    48. High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase. J Immunol. 1999 Dec 01; 163(11):6023-34. Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL. PMID: 10570290.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    49. Cbl functions downstream of Src kinases in Fc gamma RI signaling in primary human macrophages. J Leukoc Biol. 1999 Apr; 65(4):523-34. Erdreich-Epstein A, Liu M, Kant AM, Izadi KD, Nolta JA, Durden DL. PMID: 10204582.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    50. Characterization of Cbl-Nck and Nck-Pak1 interactions in myeloid FcgammaRII signaling. Exp Cell Res. 1998 Dec 15; 245(2):330-42. Izadi KD, Erdreich-Epstein A, Liu Y, Durden DL. PMID: 9851874.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    51. Differential expression of Wnt genes in normal and flat variants of PC12 cells, a cell line responsive to ectopic Wnt1 expression. Growth Factors. 1998; 15(2):149-58. Erdreich-Epstein A, Shackleford GM. PMID: 9505170.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    52. Protein tyrosine phosphatase inhibitors in Fc gamma RI-induced myeloid oxidant signaling. Exp Cell Res. 1997 Dec 15; 237(2):288-95. Erdreich-Epstein A, Liu M, Liu Y, Durden DL. PMID: 9434624.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    53. Prolonged clinical response to vincristine treatment in two patients with idiopathic hypereosinophilic syndrome. Am J Pediatr Hematol Oncol. 1992 Nov; 14(4):348-51. Sakamoto K, Erdreich-Epstein A, deClerck Y, Coates T. PMID: 1456402.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
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