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Rex A. Moats, PhD

TitleAssociate Professor of Research Pathology and Radiology
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL Mail Stop 81
Off Campus
Los Angeles CA 90089
Phone+1 323 361 8503
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    Other Positions
    TitleScientific Director of Small Animal Research


    Collapse Research 
    Collapse Research Activities and Funding
    Mathematical Modeling and Analysis of Ocular Fluid Dynamics and Transport Phenomena for Retinal Drug Delivery
    NIH/NEI R01EY026599Sep 1, 2016 - Aug 31, 2021
    Role: Co-Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Browne AW, Arnesano C, Harutyunyan N, Khuu T, Martinez JC, Pollack HA, Koos DS, Lee TC, Fraser SE, Moats R, Aparicio JG, Cobrinik D. Structural and Functional Characterization of Human Stem-Cell-Derived Retinal Organoids by Live Imaging. Invest Ophthalmol Vis Sci. 2017 07 01; 58(9):3311-3318. PMID: 28672397.
      View in: PubMed
    2. Barish ME, Herrmann K, Tang Y, Argalian Herculian S, Metz M, Aramburo S, Tirughana R, Gutova M, Annala A, Moats R, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS. Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model. Stem Cells Transl Med. 2017 Jun; 6(6):1522-1532. PMID: 28481046.
      View in: PubMed
    3. Xu J, Ren X, Pathania AS, Fernandez GE, Tran A, Zhang Y, Moats R, Shackleford GM, Erdreich-Epstein A. PID1 increases chemotherapy-induced apoptosis in medulloblastoma and glioblastoma cells in a manner that involves NF?B. Sci Rep. 2017 04 11; 7(1):835. PMID: 28400607.
      View in: PubMed
    4. Schall KA, Holoyda KA, Isani M, Schlieve C, Salisbury T, Khuu T, Debelius JW, Moats R, Pollack HA, Lien CL, Fowler K, Hou X, Knight R, Grikscheit TC. Intestinal adaptation in proximal and distal segments: Two epithelial responses diverge after intestinal separation. Surgery. 2017 04; 161(4):1016-1027. PMID: 28011012.
      View in: PubMed
    5. Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats R, Potter PM, Aboody KS. Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma. Mol Ther Oncolytics. 2017 Mar 17; 4:67-76. PMID: 28345025.
      View in: PubMed
    6. Shackleford GM, Shi XH, Swanson KS, Mahdi MY, Gonzalez-Gomez I, Asgharzadeh S, D'Apuzzo M, Erdreich-Epstein A, Moats R. BarTeL, a Genetically Versatile, Bioluminescent and Granule Neuron Precursor-Targeted Mouse Model for Medulloblastoma. PLoS One. 2016; 11(6):e0156907. PMID: 27310018; PMCID: PMC4911170.
    7. Bonne NX, Vitte J, Chareyre F, Karapetyan G, Khankaldyyan V, Tanaka K, Moats R, Giovannini M. An allograft mouse model for the study of hearing loss secondary to vestibular schwannoma growth. J Neurooncol. 2016 08; 129(1):47-56. PMID: 27177628.
      View in: PubMed
    8. Sims JD, Hwang JY, Wagner S, Alonso-Valenteen F, Hanson C, Taguiam JM, Polo R, Harutyunyan I, Karapetyan G, Sorasaenee K, Ibrahim A, Marban E, Moats R, Gray HB, Gross Z, Medina-Kauwe LK. A corrole nanobiologic elicits tissue-activated MRI contrast enhancement and tumor-targeted toxicity. J Control Release. 2015 Nov 10; 217:92-101. PMID: 26334483; PMCID: PMC4623877 [Available on 11/10/16].
    9. Buckley S, Shi W, Xu W, Frey MR, Moats R, Pardo A, Selman M, Warburton D. Increased alveolar soluble annexin V promotes lung inflammation and fibrosis. Eur Respir J. 2015 Nov; 46(5):1417-29. PMID: 26160872; PMCID: PMC4767328 [Available on 11/01/16].
    10. Li Y, Trivedi V, Truong TV, Koos DS, Lansford R, Chuong CM, Warburton D, Moats R, Fraser SE. Dynamic imaging of the growth plate cartilage reveals multiple contributors to skeletal morphogenesis. Nat Commun. 2015 Apr 13; 6:6798. PMID: 25865282; PMCID: PMC4403347.
    11. Gao F, Thompson JR, Petsios E, Erkenbrack E, Moats R, Bottjer DJ, Davidson EH. Juvenile skeletogenesis in anciently diverged sea urchin clades. Dev Biol. 2015 Apr 01; 400(1):148-58. PMID: 25641694.
      View in: PubMed
    12. Hu H, Li D, Liu S, Wang M, Moats R, Conti PS, Li Z. Integrin a2ß1 targeted GdVO4:Eu ultrathin nanosheet for multimodal PET/MR imaging. Biomaterials. 2014 Oct; 35(30):8649-58. PMID: 25043573.
      View in: PubMed
    13. Blumenfeld CM, Sadtler BF, Fernandez GE, Dara L, Nguyen C, Alonso-Valenteen F, Medina-Kauwe L, Moats R, Lewis NS, Grubbs RH, Gray HB, Sorasaenee K. Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate. J Inorg Biochem. 2014 Nov; 140:39-44. PMID: 25061689; PMCID: PMC4998051.
    14. Gutova M, Frank JA, D'Apuzzo M, Khankaldyyan V, Gilchrist MM, Annala AJ, Metz MZ, Abramyants Y, Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Blanchard MS, Lesniak MS, Kim SU, Barish ME, Aboody KS, Moats R. Magnetic resonance imaging tracking of ferumoxytol-labeled human neural stem cells: studies leading to clinical use. Stem Cells Transl Med. 2013 Oct; 2(10):766-75. PMID: 24014682; PMCID: PMC3785261.
    15. Akhtari M, Pope W, Mathern G, Moats R, Frew A, Mandelkern M. Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI. Mol Imaging Biol. 2013 Jun; 15(3):299-306. PMID: 23184607.
      View in: PubMed
    16. Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats R, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J. Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies. Sci Transl Med. 2013 May 08; 5(184):184ra59. PMID: 23658244; PMCID: PMC3864887.
    17. Blumenfeld CM, Grubbs RH, Moats R, Gray HB, Sorasaenee K. Decorating metal oxide surfaces with fluorescent chlorosulfonated corroles. Inorg Chem. 2013 May 06; 52(9):4774-6. PMID: 23611256.
      View in: PubMed
    18. Akhtari M, Bragin A, Moats R, Frew A, Mandelkern M. Imaging brain neuronal activity using functionalized magnetonanoparticles and MRI. Brain Topogr. 2012 Oct; 25(4):374-88. PMID: 22622772.
      View in: PubMed
    19. Xu J, Erdreich-Epstein A, Gonzalez-Gomez I, Melendez EY, Smbatyan G, Moats R, Rosol M, Biegel JA, Reynolds CP. Novel cell lines established from pediatric brain tumors. J Neurooncol. 2012 Apr; 107(2):269-80. PMID: 22120608; PMCID: PMC3379550.
    20. Tang Y, Sharma P, Nelson MD, Simerly R, Moats R. Automatic abdominal fat assessment in obese mice using a segmental shape model. J Magn Reson Imaging. 2011 Oct; 34(4):866-73. PMID: 21769982.
      View in: PubMed
    21. Tang Y, Lee S, Nelson MD, Richard S, Moats R. Adipose segmentation in small animals at 7T: a preliminary study. BMC Genomics. 2010 Dec 01; 11 Suppl 3:S9. PMID: 21143791; PMCID: PMC2999354.
    22. Thu MS, Najbauer J, Kendall SE, Harutyunyan I, Sangalang N, Gutova M, Metz MZ, Garcia E, Frank RT, Kim SU, Moats R, Aboody KS. Iron labeling and pre-clinical MRI visualization of therapeutic human neural stem cells in a murine glioma model. PLoS One. 2009 Sep 29; 4(9):e7218. PMID: 19787043; PMCID: PMC2746284.
    23. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. PMID: 19444874; PMCID: PMC2754739.
    24. Tang Y, Jackson H, Lee S, Nelson M, Moats R. Shape-aided kidney extraction in MR urography. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5781-4. PMID: 19963658.
      View in: PubMed
    25. Wen X, Zou Y, Luo W, Goldberg M, Moats R, Conti PS, Snead ML, Paine ML. Biglycan overexpression on tooth enamel formation in transgenic mice. Anat Rec (Hoboken). 2008 Oct; 291(10):1246-53. PMID: 18727043; PMCID: PMC2562349.
    26. Wood JC, Aguilar M, Otto-Duessel M, Nick H, Nelson MD, Moats R. Influence of iron chelation on R1 and R2 calibration curves in gerbil liver and heart. Magn Reson Med. 2008 Jul; 60(1):82-9. PMID: 18581418; PMCID: PMC2525452.
    27. Akhtari M, Bragin A, Cohen M, Moats R, Brenker F, Lynch MD, Vinters HV, Engel J. Functionalized magnetonanoparticles for MRI diagnosis and localization in epilepsy. Epilepsia. 2008 Aug; 49(8):1419-30. PMID: 18479391; PMCID: PMC2685186.
    28. Otto-Duessel M, Aguilar M, Moats R, Wood JC. Antioxidant-mediated effects in a gerbil model of iron overload. Acta Haematol. 2007; 118(4):193-9. PMID: 17940334; PMCID: PMC2892915.
    29. Peng H, Sohara Y, Moats R, Nelson MD, Groshen SG, Ye W, Reynolds CP, DeClerck YA. The activity of zoledronic Acid on neuroblastoma bone metastasis involves inhibition of osteoclasts and tumor cell survival and proliferation. Cancer Res. 2007 Oct 01; 67(19):9346-55. PMID: 17909043.
      View in: PubMed
    30. Liao CP, Zhong C, Saribekyan G, Bading J, Park R, Conti PS, Moats R, Berns A, Shi W, Zhou Z, Nikitin AY, Roy-Burman P. Mouse models of prostate adenocarcinoma with the capacity to monitor spontaneous carcinogenesis by bioluminescence or fluorescence. Cancer Res. 2007 Aug 01; 67(15):7525-33. PMID: 17671224.
      View in: PubMed
    31. Otto-Duessel M, Aguilar M, Nick H, Moats R, Wood JC. Comparison of twice-daily vs once-daily deferasirox dosing in a gerbil model of iron cardiomyopathy. Exp Hematol. 2007 Jul; 35(7):1069-73. PMID: 17588475; PMCID: PMC2892931.
    32. Wood JC, Otto-Duessel M, Gonzalez I, Aguilar MI, Shimada H, Nick H, Nelson M, Moats R. Deferasirox and deferiprone remove cardiac iron in the iron-overloaded gerbil. Transl Res. 2006 Nov; 148(5):272-80. PMID: 17145573; PMCID: PMC2896322.
    33. Sodir NM, Chen X, Park R, Nickel AE, Conti PS, Moats R, Bading JR, Shibata D, Laird PW. Smad3 deficiency promotes tumorigenesis in the distal colon of ApcMin/+ mice. Cancer Res. 2006 Sep 01; 66(17):8430-8. PMID: 16951153.
      View in: PubMed
    34. Mouchess ML, Sohara Y, Nelson MD, DeCLerck YA, Moats R. Multimodal imaging analysis of tumor progression and bone resorption in a murine cancer model. J Comput Assist Tomogr. 2006 May-Jun; 30(3):525-34. PMID: 16778634.
      View in: PubMed
    35. Chen X, Park R, Khankaldyyan V, Gonzales-Gomez I, Tohme M, Moats R, Bading JR, Laug WE, Conti PS. Longitudinal microPET imaging of brain tumor growth with F-18-labeled RGD peptide. Mol Imaging Biol. 2006 Jan-Feb; 8(1):9-15. PMID: 16315003.
      View in: PubMed
    36. Chaudhari AJ, Darvas F, Bading JR, Moats R, Conti PS, Smith DJ, Cherry SR, Leahy RM. Hyperspectral and multispectral bioluminescence optical tomography for small animal imaging. Phys Med Biol. 2005 Dec 07; 50(23):5421-41. PMID: 16306643.
      View in: PubMed
    37. Møller LB, Paulsen M, Koch R, Moats R, Guldberg P, Güttler F. Inter-individual variation in brain phenylalanine concentration in patients with PKU is not caused by genetic variation in the 4F2hc/LAT1 complex. Mol Genet Metab. 2005 Dec; 86 Suppl 1:S119-23. PMID: 16176881.
      View in: PubMed
    38. Wood JC, Otto-Duessel M, Aguilar M, Nick H, Nelson MD, Coates TD, Pollack H, Moats R. Cardiac iron determines cardiac T2*, T2, and T1 in the gerbil model of iron cardiomyopathy. Circulation. 2005 Jul 26; 112(4):535-43. PMID: 16027257; PMCID: PMC2896311.
    39. Kobayashi H, Carbonaro D, Pepper K, Petersen D, Ge S, Jackson H, Shimada H, Moats R, Kohn DB. Neonatal gene therapy of MPS I mice by intravenous injection of a lentiviral vector. Mol Ther. 2005 May; 11(5):776-89. PMID: 15851016.
      View in: PubMed
    40. Reynolds CP, Sun BC, DeClerck YA, Moats R. Assessing growth and response to therapy in murine tumor models. Methods Mol Med. 2005; 111:335-50. PMID: 15911989.
      View in: PubMed
    41. Wood JC, Enriquez C, Ghugre N, Otto-Duessel M, Aguilar M, Nelson MD, Moats R, Coates TD. Physiology and pathophysiology of iron cardiomyopathy in thalassemia. Ann N Y Acad Sci. 2005; 1054:386-95. PMID: 16339687; PMCID: PMC2892916.
    42. Chen X, Conti PS, Moats R. In vivo near-infrared fluorescence imaging of integrin alphavbeta3 in brain tumor xenografts. Cancer Res. 2004 Nov 01; 64(21):8009-14. PMID: 15520209.
      View in: PubMed
    43. Chen X, Park R, Shahinian AH, Tohme M, Khankaldyyan V, Bozorgzadeh MH, Bading JR, Moats R, Laug WE, Conti PS. 18F-labeled RGD peptide: initial evaluation for imaging brain tumor angiogenesis. Nucl Med Biol. 2004 Feb; 31(2):179-89. PMID: 15013483.
      View in: PubMed
    44. Moats R, Moseley KD, Koch R, Nelson M. Brain phenylalanine concentrations in phenylketonuria: research and treatment of adults. Pediatrics. 2003 Dec; 112(6 Pt 2):1575-9. PMID: 14654668.
      View in: PubMed
    45. Moats R, Velan-Mullan S, Jacobs R, Gonzalez-Gomez I, Dubowitz DJ, Taga T, Khankaldyyan V, Schultz L, Fraser S, Nelson MD, Laug WE. Micro-MRI at 11.7 T of a murine brain tumor model using delayed contrast enhancement. Mol Imaging. 2003 Jul; 2(3):150-8. PMID: 14649058.
      View in: PubMed
    46. Koch R, Moseley KD, Yano S, Nelson M, Moats R. Large neutral amino acid therapy and phenylketonuria: a promising approach to treatment. Mol Genet Metab. 2003 Jun; 79(2):110-3. PMID: 12809641.
      View in: PubMed
    47. Zhang X, Kuroda S, Carpenter D, Nishimura I, Soo C, Moats R, Iida K, Wisner E, Hu FY, Miao S, Beanes S, Dang C, Vastardis H, Longaker M, Tanizawa K, Kanayama N, Saito N, Ting K. Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest. 2002 Sep; 110(6):861-70. PMID: 12235118; PMCID: PMC151127.
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