Steve Kay, PhD

TitleProvost Professor of Neurology, Biomedical Engineering and Biological Sciences, Director of Convergent Bioscience
InstitutionUniversity of Southern California
DepartmentZilkha Neurogenetic Institute
AddressKAM 500
Health Sciences Campus
Los Angeles CA 90089-4012
Phone+1 323 442 1900
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Perrella G, Davidson MLH, O'Donnell L, Nastase AM, Herzyk P, Breton G, Pruneda-Paz JL, Kay S, Chory J, Kaiserli E. ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis. Proc Natl Acad Sci U S A. 2018 May 08; 115(19):E4503-E4511. PMID: 29686058.
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    2. Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay S, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptácek LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Guidelines for Genome-Scale Analysis of Biological Rhythms. J Biol Rhythms. 2017 Oct; 32(5):380-393. PMID: 29098954.
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    3. Li X, Yang H, Sun H, Lu R, Zhang C, Gao N, Meng Q, Wu S, Wang S, Aschner M, Wu J, Tang B, Gu A, Kay S, Chen R. Taurine ameliorates particulate matter-induced emphysema by switching on mitochondrial NADH dehydrogenase genes. Proc Natl Acad Sci U S A. 2017 Nov 07; 114(45):E9655-E9664. PMID: 29078374.
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    4. Xiao J, Jin R, Yu X, Shen M, Wagner JD, Pai A, Song C, Zhuang M, Klasfeld S, He C, Santos AM, Helliwell C, Pruneda-Paz JL, Kay S, Lin X, Cui S, Garcia MF, Clarenz O, Goodrich J, Zhang X, Austin RS, Bonasio R, Wagner D. Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Nat Genet. 2017 Oct; 49(10):1546-1552. PMID: 28825728.
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    5. Tripathi P, Pruneda-Paz JL, Kay S. A Modified Yeast-one Hybrid System for Heteromeric Protein Complex-DNA Interaction Studies. J Vis Exp. 2017 07 24; (125). PMID: 28784944.
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    6. Kubota A, Ito S, Shim JS, Johnson RS, Song YH, Breton G, Goralogia GS, Kwon MS, Laboy Cintrón D, Koyama T, Ohme-Takagi M, Pruneda-Paz JL, Kay S, MacCoss MJ, Imaizumi T. TCP4-dependent induction of CONSTANS transcription requires GIGANTEA in photoperiodic flowering in Arabidopsis. PLoS Genet. 2017 Jun; 13(6):e1006856. PMID: 28628608.
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    7. Shani E, Salehin M, Zhang Y, Sanchez SE, Doherty C, Wang R, Mangado CC, Song L, Tal I, Pisanty O, Ecker JR, Kay S, Pruneda-Paz J, Estelle M. Plant Stress Tolerance Requires Auxin-Sensitive Aux/IAA Transcriptional Repressors. Curr Biol. 2017 Feb 06; 27(3):437-444. PMID: 28111153.
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    8. Boyle G, Richter K, Priest HD, Traver D, Mockler TC, Chang JT, Kay S, Breton G. Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes. PLoS One. 2017; 12(1):e0169923. PMID: 28076377.
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    9. Tripathi P, Carvallo M, Hamilton EE, Preuss S, Kay S. Arabidopsis B-BOX32 interacts with CONSTANS-LIKE3 to regulate flowering. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):172-177. PMID: 27999181.
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    10. Nohales MA, Kay S. Molecular mechanisms at the core of the plant circadian oscillator. Nat Struct Mol Biol. 2016 Dec; 23(12):1061-1069. PMID: 27922614.
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    11. Sanchez SE, Kay S. The Plant Circadian Clock: From a Simple Timekeeper to a Complex Developmental Manager. Cold Spring Harb Perspect Biol. 2016 Dec 01; 8(12). PMID: 27663772.
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    12. Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR, Kay S, Downes M, Evans RM. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBa Degradation. Cell. 2016 Jun 16; 165(7):1644-1657. PMID: 27238018; PMCID: PMC4912445 [Available on 06/16/17].
    13. Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay S, Craig EA, Mogk A, Bukau B, Joazeiro CA. The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. Elife. 2016 Mar 04; 5:e11794. PMID: 26943317; PMCID: PMC4805532.
    14. Kay S, Remigereau MS. Cultivated tomato clock runs slow. Nat Genet. 2016 Jan; 48(1):8-9. PMID: 26711110.
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    15. Breton G, Kay S, Pruneda-Paz JL. Identification of Arabidopsis Transcriptional Regulators by Yeast One-Hybrid Screens Using a Transcription Factor ORFeome. Methods Mol Biol. 2016; 1398:107-18. PMID: 26867619.
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    16. Kaiserli E, Páldi K, O'Donnell L, Batalov O, Pedmale UV, Nusinow DA, Kay S, Chory J. Integration of Light and Photoperiodic Signaling in Transcriptional Nuclear Foci. Dev Cell. 2015 Nov 09; 35(3):311-21. PMID: 26555051; PMCID: PMC4654455 [Available on 11/09/16].
    17. Huang H, Alvarez S, Bindbeutel R, Shen Z, Naldrett MJ, Evans BS, Briggs SP, Hicks LM, Kay S, Nusinow DA. Identification of Evening Complex Associated Proteins in Arabidopsis by Affinity Purification and Mass Spectrometry. Mol Cell Proteomics. 2016 Jan; 15(1):201-17. PMID: 26545401; PMCID: PMC4762519.
    18. Nagel DH, Doherty CJ, Pruneda-Paz JL, Schmitz RJ, Ecker JR, Kay S. Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):E4802-10. PMID: 26261339; PMCID: PMC4553765.
    19. Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay S. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. ChemMedChem. 2015 Sep; 10(9):1489-97. PMID: 26174033; PMCID: PMC4576822.
    20. Waadt R, Manalansan B, Rauniyar N, Munemasa S, Booker MA, Brandt B, Waadt C, Nusinow DA, Kay S, Kunz HH, Schumacher K, DeLong A, Yates JR, Schroeder JI. Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses. Plant Physiol. 2015 Sep; 169(1):760-79. PMID: 26175513; PMCID: PMC4577397.
    21. Zheng XY, Zhou M, Yoo H, Pruneda-Paz JL, Spivey NW, Kay S, Dong X. Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):9166-73. PMID: 26139525; PMCID: PMC4522758.
    22. Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay S, Yoshimura T, Itami K. C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock. Angew Chem Int Ed Engl. 2015 Jun 08; 54(24):7193-7. PMID: 25960183.
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    23. Tang B, He H, Ding Q, Kay S. A parametric classification rule based on the exponentially embedded family. IEEE Trans Neural Netw Learn Syst. 2015 Feb; 26(2):367-77. PMID: 25585428.
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    24. Hirota T, Kay S. Identification of small-molecule modulators of the circadian clock. Methods Enzymol. 2015; 551:267-82. PMID: 25662461.
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    25. Endo M, Shimizu H, Nohales MA, Araki T, Kay S. Tissue-specific clocks in Arabidopsis show asymmetric coupling. Nature. 2014 Nov 20; 515(7527):419-22. PMID: 25363766; PMCID: PMC4270698.
    26. Kolmos E, Chow BY, Pruneda-Paz JL, Kay S. HsfB2b-mediated repression of PRR7 directs abiotic stress responses of the circadian clock. Proc Natl Acad Sci U S A. 2014 Nov 11; 111(45):16172-7. PMID: 25352668; PMCID: PMC4234549.
    27. Zhou Y, Liu X, Engstrom EM, Nimchuk ZL, Pruneda-Paz JL, Tarr PT, Yan A, Kay S, Meyerowitz EM. Control of plant stem cell function by conserved interacting transcriptional regulators. Nature. 2015 Jan 15; 517(7534):377-80. PMID: 25363783; PMCID: PMC4297503.
    28. Guan P, Wang R, Nacry P, Breton G, Kay S, Pruneda-Paz JL, Davani A, Crawford NM. Nitrate foraging by Arabidopsis roots is mediated by the transcription factor TCP20 through the systemic signaling pathway. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15267-72. PMID: 25288754; PMCID: PMC4210337.
    29. Nagel DH, Pruneda-Paz JL, Kay S. FBH1 affects warm temperature responses in the Arabidopsis circadian clock. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14595-600. PMID: 25246594; PMCID: PMC4210019.
    30. Pruneda-Paz JL, Breton G, Nagel DH, Kang SE, Bonaldi K, Doherty CJ, Ravelo S, Galli M, Ecker JR, Kay S. A genome-scale resource for the functional characterization of Arabidopsis transcription factors. Cell Rep. 2014 Jul 24; 8(2):622-32. PMID: 25043187; PMCID: PMC4125603.
    31. Chow BY, Sanchez SE, Breton G, Pruneda-Paz JL, Krogan NT, Kay S. Transcriptional regulation of LUX by CBF1 mediates cold input to the circadian clock in Arabidopsis. Curr Biol. 2014 Jul 07; 24(13):1518-24. PMID: 24954045; PMCID: PMC4090264.
    32. Matos DA, Cole BJ, Whitney IP, MacKinnon KJ, Kay S, Hazen SP. Daily changes in temperature, not the circadian clock, regulate growth rate in Brachypodium distachyon. PLoS One. 2014; 9(6):e100072. PMID: 24927130; PMCID: PMC4057399.
    33. St John PC, Hirota T, Kay S, Doyle FJ. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):2040-5. PMID: 24449901; PMCID: PMC3918757.
    34. Weger M, Weger BD, Diotel N, Rastegar S, Hirota T, Kay S, Strähle U, Dickmeis T. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Dev Biol. 2013 Aug 15; 380(2):259-73. PMID: 23665472.
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    35. Niwa M, Daimon Y, Kurotani K, Higo A, Pruneda-Paz JL, Breton G, Mitsuda N, Kay S, Ohme-Takagi M, Endo M, Araki T. BRANCHED1 interacts with FLOWERING LOCUS T to repress the floral transition of the axillary meristems in Arabidopsis. Plant Cell. 2013 Apr; 25(4):1228-42. PMID: 23613197; PMCID: PMC3663264.
    36. Chow BY, Kay S. Global approaches for telling time: omics and the Arabidopsis circadian clock. Semin Cell Dev Biol. 2013 May; 24(5):383-92. PMID: 23435351; PMCID: PMC3759395.
    37. Doherty CJ, Kay S. Circadian surprise--it's not all about transcription. Science. 2012 Oct 19; 338(6105):338-40. PMID: 23087238.
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    38. Lai AG, Doherty CJ, Mueller-Roeber B, Kay S, Schippers JH, Dijkwel PP. CIRCADIAN CLOCK-ASSOCIATED 1 regulates ROS homeostasis and oxidative stress responses. Proc Natl Acad Sci U S A. 2012 Oct 16; 109(42):17129-34. PMID: 23027948; PMCID: PMC3479464.
    39. Nagel DH, Kay S. Complexity in the wiring and regulation of plant circadian networks. Curr Biol. 2012 Aug 21; 22(16):R648-57. PMID: 22917516; PMCID: PMC3427731.
    40. Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay S. Identification of small molecule activators of cryptochrome. Science. 2012 Aug 31; 337(6098):1094-7. PMID: 22798407; PMCID: PMC3589997.
    41. Li L, Ljung K, Breton G, Schmitz RJ, Pruneda-Paz J, Cowing-Zitron C, Cole BJ, Ivans LJ, Pedmale UV, Jung HS, Ecker JR, Kay S, Chory J. Linking photoreceptor excitation to changes in plant architecture. Genes Dev. 2012 Apr 15; 26(8):785-90. PMID: 22508725; PMCID: PMC3337452.
    42. Gendron JM, Pruneda-Paz JL, Doherty CJ, Gross AM, Kang SE, Kay S. Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3167-72. PMID: 22315425; PMCID: PMC3286946.
    43. Sawa M, Kay S. [Circadian clocks and photoperiodism]. Fukuoka Igaku Zasshi. 2012 Feb; 103(2):29-34. PMID: 22568125.
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    44. Atwood A, Kay S. Cell-autonomous hepatic circadian clock regulates polyamine synthesis. Cell Cycle. 2012 Feb 01; 11(3):422-3. PMID: 22262187.
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    45. Chow BY, Helfer A, Nusinow DA, Kay S. ELF3 recruitment to the PRR9 promoter requires other Evening Complex members in the Arabidopsis circadian clock. Plant Signal Behav. 2012 Feb; 7(2):170-3. PMID: 22307044; PMCID: PMC3405715.
    46. Taton A, Lis E, Adin DM, Dong G, Cookson S, Kay S, Golden SS, Golden JW. Gene transfer in Leptolyngbya sp. strain BL0902, a cyanobacterium suitable for production of biomass and bioproducts. PLoS One. 2012; 7(1):e30901. PMID: 22292073.
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    47. Atwood A, DeConde R, Wang SS, Mockler TC, Sabir JS, Ideker T, Kay S. Cell-autonomous circadian clock of hepatocytes drives rhythms in transcription and polyamine synthesis. Proc Natl Acad Sci U S A. 2011 Nov 08; 108(45):18560-5. PMID: 22042857; PMCID: PMC3215069.
    48. Gaudinier A, Zhang L, Reece-Hoyes JS, Taylor-Teeples M, Pu L, Liu Z, Breton G, Pruneda-Paz JL, Kim D, Kay S, Walhout AJ, Ware D, Brady SM. Enhanced Y1H assays for Arabidopsis. Nat Methods. 2011 Oct 30; 8(12):1053-5. PMID: 22037706; PMCID: PMC3821074.
    49. Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay S. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angew Chem Int Ed Engl. 2011 Nov 04; 50(45):10608-11. PMID: 21954091; PMCID: PMC3755734.
    50. Nusinow DA, Helfer A, Hamilton EE, King JJ, Imaizumi T, Schultz TF, Farré EM, Kay S. The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth. Nature. 2011 Jul 13; 475(7356):398-402. PMID: 21753751.
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    51. Sawa M, Kay S. GIGANTEA directly activates Flowering Locus T in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11698-703. PMID: 21709243; PMCID: PMC3136272.
    52. Filichkin SA, Breton G, Priest HD, Dharmawardhana P, Jaiswal P, Fox SE, Michael TP, Chory J, Kay S, Mockler TC. Global profiling of rice and poplar transcriptomes highlights key conserved circadian-controlled pathways and cis-regulatory modules. PLoS One. 2011; 6(6):e16907. PMID: 21694767; PMCID: PMC3111414.
    53. Cole B, Kay S, Chory J. Automated analysis of hypocotyl growth dynamics during shade avoidance in Arabidopsis. Plant J. 2011 Mar; 65(6):991-1000. PMID: 21288269; PMCID: PMC3076959.
    54. Helfer A, Nusinow DA, Chow BY, Gehrke AR, Bulyk ML, Kay S. LUX ARRHYTHMO encodes a nighttime repressor of circadian gene expression in the Arabidopsis core clock. Curr Biol. 2011 Jan 25; 21(2):126-33. PMID: 21236673; PMCID: PMC3057456.
    55. Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay S. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIa as a clock regulatory kinase. PLoS Biol. 2010 Dec 14; 8(12):e1000559. PMID: 21179498; PMCID: PMC3001897.
    56. Zhang EE, Kay S. Clocks not winding down: unravelling circadian networks. Nat Rev Mol Cell Biol. 2010 Nov; 11(11):764-76. PMID: 20966970.
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    57. Ko CH, Yamada YR, Welsh DK, Buhr ED, Liu AC, Zhang EE, Ralph MR, Kay S, Forger DB, Takahashi JS. Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol. 2010 Oct 12; 8(10):e1000513. PMID: 20967239; PMCID: PMC2953532.
    58. Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay S. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nat Med. 2010 Oct; 16(10):1152-6. PMID: 20852621; PMCID: PMC2952072.
    59. Pruneda-Paz JL, Kay S. An expanding universe of circadian networks in higher plants. Trends Plant Sci. 2010 May; 15(5):259-65. PMID: 20382065; PMCID: PMC2866796.
    60. Baudry A, Ito S, Song YH, Strait AA, Kiba T, Lu S, Henriques R, Pruneda-Paz JL, Chua NH, Tobin EM, Kay S, Imaizumi T. F-box proteins FKF1 and LKP2 act in concert with ZEITLUPE to control Arabidopsis clock progression. Plant Cell. 2010 Mar; 22(3):606-22. PMID: 20354196; PMCID: PMC2861467.
    61. Doherty CJ, Kay S. Circadian control of global gene expression patterns. Annu Rev Genet. 2010; 44:419-44. PMID: 20809800; PMCID: PMC4251774.
    62. Welsh DK, Takahashi JS, Kay S. Suprachiasmatic nucleus: cell autonomy and network properties. Annu Rev Physiol. 2010; 72:551-77. PMID: 20148688; PMCID: PMC3758475.
    63. Hirota T, Kay S. High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chem Biol. 2009 Sep 25; 16(9):921-7. PMID: 19778719; PMCID: PMC2835411.
    64. Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB, Kay S. A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell. 2009 Oct 02; 139(1):199-210. PMID: 19765810; PMCID: PMC2777987.
    65. Mirsky HP, Liu AC, Welsh DK, Kay S, Doyle FJ. A model of the cell-autonomous mammalian circadian clock. Proc Natl Acad Sci U S A. 2009 Jul 07; 106(27):11107-12. PMID: 19549830; PMCID: PMC2699375.
    66. Hung HC, Kay S, Weber F. HSP90, a capacitor of behavioral variation. J Biol Rhythms. 2009 Jun; 24(3):183-92. PMID: 19465695.
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    67. Pan Y, Michael TP, Hudson ME, Kay S, Chory J, Schuler MA. Cytochrome P450 monooxygenases as reporters for circadian-regulated pathways. Plant Physiol. 2009 Jun; 150(2):858-78. PMID: 19386812; PMCID: PMC2689971.
    68. Pruneda-Paz JL, Breton G, Para A, Kay S. A functional genomics approach reveals CHE as a component of the Arabidopsis circadian clock. Science. 2009 Mar 13; 323(5920):1481-5. PMID: 19286557; PMCID: PMC4259050.
    69. Hazen SP, Naef F, Quisel T, Gendron JM, Chen H, Ecker JR, Borevitz JO, Kay S. Exploring the transcriptional landscape of plant circadian rhythms using genome tiling arrays. Genome Biol. 2009 Feb 11; 10(2):R17. PMID: 19210792.
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    70. Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay S. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2097-103. PMID: 19196968; PMCID: PMC2650114.
    71. Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay S. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20746-51. PMID: 19104043; PMCID: PMC2606900.
    72. Hamilton EE, Kay S. SnapShot: circadian clock proteins. Cell. 2008 Oct 17; 135(2):368-368.e1. PMID: 18957209.
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    73. Michael TP, Breton G, Hazen SP, Priest H, Mockler TC, Kay S, Chory J. A morning-specific phytohormone gene expression program underlying rhythmic plant growth. PLoS Biol. 2008 Sep 16; 6(9):e225. PMID: 18798691; PMCID: PMC2535664.
    74. Covington MF, Maloof JN, Straume M, Kay S, Harmer SL. Global transcriptome analysis reveals circadian regulation of key pathways in plant growth and development. Genome Biol. 2008; 9(8):R130. PMID: 18710561; PMCID: PMC2575520.
    75. Sawa M, Kay S. [Molecular mechanism by which plant determines flowering timing with circadian clock]. Tanpakushitsu Kakusan Koso. 2008 May; 53(6):739-46. PMID: 18453150.
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    76. Sawa M, Kay S, Imaizumi T. Photoperiodic flowering occurs under internal and external coincidence. Plant Signal Behav. 2008 Apr; 3(4):269-71. PMID: 19704651; PMCID: PMC2634199.
    77. Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay S. Redundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythms. PLoS Genet. 2008 Feb 29; 4(2):e1000023. PMID: 18454201; PMCID: PMC2265523.
    78. Michael TP, Mockler TC, Breton G, McEntee C, Byer A, Trout JD, Hazen SP, Shen R, Priest HD, Sullivan CM, Givan SA, Yanovsky M, Hong F, Kay S, Chory J. Network discovery pipeline elucidates conserved time-of-day-specific cis-regulatory modules. PLoS Genet. 2008 Feb; 4(2):e14. PMID: 18248097; PMCID: PMC2222925.
    79. Para A, Farré EM, Imaizumi T, Pruneda-Paz JL, Harmon FG, Kay S. PRR3 Is a vascular regulator of TOC1 stability in the Arabidopsis circadian clock. Plant Cell. 2007 Nov; 19(11):3462-73. PMID: 18055606; PMCID: PMC2174887.
    80. Imaizumi T, Kay S, Schroeder JI. Circadian rhythms. Daily watch on metabolism. Science. 2007 Dec 14; 318(5857):1730-1. PMID: 18006706; PMCID: PMC3725277.
    81. Liu AC, Lewis WG, Kay S. Mammalian circadian signaling networks and therapeutic targets. Nat Chem Biol. 2007 Oct; 3(10):630-9. PMID: 17876320.
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    82. Farré EM, Kay S. PRR7 protein levels are regulated by light and the circadian clock in Arabidopsis. Plant J. 2007 Nov; 52(3):548-60. PMID: 17877705.
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    83. Sawa M, Nusinow DA, Kay S, Imaizumi T. FKF1 and GIGANTEA complex formation is required for day-length measurement in Arabidopsis. Science. 2007 Oct 12; 318(5848):261-5. PMID: 17872410; PMCID: PMC3709017.
    84. Breton G, Kay S. Plant biology: time for growth. Nature. 2007 Jul 19; 448(7151):265-6. PMID: 17637650.
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    85. Hung HC, Maurer C, Kay S, Weber F. Circadian transcription depends on limiting amounts of the transcription co-activator nejire/CBP. J Biol Chem. 2007 Oct 26; 282(43):31349-57. PMID: 17635913.
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    86. Borevitz JO, Hazen SP, Michael TP, Morris GP, Baxter IR, Hu TT, Chen H, Werner JD, Nordborg M, Salt DE, Kay S, Chory J, Weigel D, Jones JD, Ecker JR. Genome-wide patterns of single-feature polymorphism in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12057-62. PMID: 17626786; PMCID: PMC1914337.
    87. Imaizumi T, Schroeder JI, Kay S. In SYNC: the ins and outs of circadian oscillations in calcium. Sci STKE. 2007 Jun 12; 2007(390):pe32. PMID: 17565121; PMCID: PMC3737242.
    88. Liu AC, Welsh DK, Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker K, Verma IM, Doyle FJ, Takahashi JS, Kay S. Intercellular coupling confers robustness against mutations in the SCN circadian clock network. Cell. 2007 May 04; 129(3):605-16. PMID: 17482552; PMCID: PMC3749832.
    89. Fernández MP, Chu J, Villella A, Atkinson N, Kay S, Ceriani MF. Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5650-5. PMID: 17369364; PMCID: PMC1838506.
    90. Faigón-Soverna A, Harmon FG, Storani L, Karayekov E, Staneloni RJ, Gassmann W, Más P, Casal JJ, Kay S, Yanovsky MJ. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell. 2006 Nov; 18(11):2919-28. PMID: 17114357; PMCID: PMC1693933.
    91. Zeilinger MN, Farré EM, Taylor SR, Kay S, Doyle FJ. A novel computational model of the circadian clock in Arabidopsis that incorporates PRR7 and PRR9. Mol Syst Biol. 2006; 2:58. PMID: 17102803; PMCID: PMC1682023.
    92. Imaizumi T, Kay S. Photoperiodic control of flowering: not only by coincidence. Trends Plant Sci. 2006 Nov; 11(11):550-8. PMID: 17035069.
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    93. Allen T, Koustenis A, Theodorou G, Somers DE, Kay S, Whitelam GC, Devlin PF. Arabidopsis FHY3 specifically gates phytochrome signaling to the circadian clock. Plant Cell. 2006 Oct; 18(10):2506-16. PMID: 17012604; PMCID: PMC1626623.
    94. Weber F, Hung HC, Maurer C, Kay S. Second messenger and Ras/MAPK signalling pathways regulate CLOCK/CYCLE-dependent transcription. J Neurochem. 2006 Jul; 98(1):248-57. PMID: 16805811.
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    95. Breton G, Kay S. Circadian rhythms lit up in Chlamydomonas. Genome Biol. 2006; 7(4):215. PMID: 16677428; PMCID: PMC1557987.
    96. Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay S, Ueda HR, Hogenesch JB. Feedback repression is required for mammalian circadian clock function. Nat Genet. 2006 Mar; 38(3):312-9. PMID: 16474406; PMCID: PMC1994933.
    97. Hazen SP, Schultz TF, Pruneda-Paz JL, Borevitz JO, Ecker JR, Kay S. LUX ARRHYTHMO encodes a Myb domain protein essential for circadian rhythms. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10387-92. PMID: 16006522; PMCID: PMC1177380.
    98. Imaizumi T, Schultz TF, Harmon FG, Ho LA, Kay S. FKF1 F-box protein mediates cyclic degradation of a repressor of CONSTANS in Arabidopsis. Science. 2005 Jul 08; 309(5732):293-7. PMID: 16002617.
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    99. Harmer SL, Kay S. Positive and negative factors confer phase-specific circadian regulation of transcription in Arabidopsis. Plant Cell. 2005 Jul; 17(7):1926-40. PMID: 15923346; PMCID: PMC1167542.
    100. Hazen SP, Borevitz JO, Harmon FG, Pruneda-Paz JL, Schultz TF, Yanovsky MJ, Liljegren SJ, Ecker JR, Kay S. Rapid array mapping of circadian clock and developmental mutations in Arabidopsis. Plant Physiol. 2005 Jun; 138(2):990-7. PMID: 15908595; PMCID: PMC1150413.
    101. Welsh DK, Kay S. Bioluminescence imaging in living organisms. Curr Opin Biotechnol. 2005 Feb; 16(1):73-8. PMID: 15722018.
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    102. Farré EM, Harmer SL, Harmon FG, Yanovsky MJ, Kay S. Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock. Curr Biol. 2005 Jan 11; 15(1):47-54. PMID: 15649364.
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    103. Welsh DK, Imaizumi T, Kay S. Real-time reporting of circadian-regulated gene expression by luciferase imaging in plants and mammalian cells. Methods Enzymol. 2005; 393:269-88. PMID: 15817294.
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    104. Welsh DK, Yoo SH, Liu AC, Takahashi JS, Kay S. Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression. Curr Biol. 2004 Dec 29; 14(24):2289-95. PMID: 15620658; PMCID: PMC3777438.
    105. Flechner SM, Kurian SM, Head SR, Sharp SM, Whisenant TC, Zhang J, Chismar JD, Horvath S, Mondala T, Gilmartin T, Cook DJ, Kay S, Walker JR, Salomon DR. Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant. 2004 Sep; 4(9):1475-89. PMID: 15307835; PMCID: PMC2041877.
    106. Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay S, Hogenesch JB. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004 Aug 19; 43(4):527-37. PMID: 15312651.
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    107. Ueda HR, Hayashi S, Matsuyama S, Yomo T, Hashimoto S, Kay S, Hogenesch JB, Iino M. Universality and flexibility in gene expression from bacteria to human. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3765-9. PMID: 14999098; PMCID: PMC374318.
    108. Weber F, Kay S. A PERIOD inhibitor buffer introduces a delay mechanism for CLK/CYC-activated transcription. FEBS Lett. 2003 Dec 04; 555(2):341-5. PMID: 14644439.
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    109. Más P, Kim WY, Somers DE, Kay S. Targeted degradation of TOC1 by ZTL modulates circadian function in Arabidopsis thaliana. Nature. 2003 Dec 04; 426(6966):567-70. PMID: 14654842.
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    110. Harmon FG, Kay S. The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling. Curr Biol. 2003 Dec 02; 13(23):2091-6. PMID: 14653999.
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    111. Devlin PF, Yanovsky MJ, Kay S. A genomic analysis of the shade avoidance response in Arabidopsis. Plant Physiol. 2003 Dec; 133(4):1617-29. PMID: 14645734; PMCID: PMC300718.
    112. Imaizumi T, Tran HG, Swartz TE, Briggs WR, Kay S. FKF1 is essential for photoperiodic-specific light signalling in Arabidopsis. Nature. 2003 Nov 20; 426(6964):302-6. PMID: 14628054.
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    113. Maxwell BB, Andersson CR, Poole DS, Kay S, Chory J. HY5, Circadian Clock-Associated 1, and a cis-element, DET1 dark response element, mediate DET1 regulation of chlorophyll a/b-binding protein 2 expression. Plant Physiol. 2003 Dec; 133(4):1565-77. PMID: 14563928; PMCID: PMC300714.
    114. Hazen SP, Kay S. Gene arrays are not just for measuring gene expression. Trends Plant Sci. 2003 Sep; 8(9):413-6. PMID: 13678907.
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    115. Schultz TF, Kay S. Circadian clocks in daily and seasonal control of development. Science. 2003 Jul 18; 301(5631):326-8. PMID: 12869749.
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    116. Panda S, Provencio I, Tu DC, Pires SS, Rollag MD, Castrucci AM, Pletcher MT, Sato TK, Wiltshire T, Andahazy M, Kay S, Van Gelder RN, Hogenesch JB. Melanopsin is required for non-image-forming photic responses in blind mice. Science. 2003 Jul 25; 301(5632):525-7. PMID: 12829787.
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    117. Sato TK, Panda S, Kay S, Hogenesch JB. DNA arrays: applications and implications for circadian biology. J Biol Rhythms. 2003 Apr; 18(2):96-105. PMID: 12693865.
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    118. Yanovsky MJ, Kay S. Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol. 2003 Apr; 4(4):265-75. PMID: 12671649.
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    119. Wiltshire T, Pletcher MT, Batalov S, Barnes SW, Tarantino LM, Cooke MP, Wu H, Smylie K, Santrosyan A, Copeland NG, Jenkins NA, Kalush F, Mural RJ, Glynne RJ, Kay S, Adams MD, Fletcher CF. Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3380-5. PMID: 12612341; PMCID: PMC152301.
    120. Más P, Alabadí D, Yanovsky MJ, Oyama T, Kay S. Dual role of TOC1 in the control of circadian and photomorphogenic responses in Arabidopsis. Plant Cell. 2003 Jan; 15(1):223-36. PMID: 12509533; PMCID: PMC143493.
    121. Panda S, Hogenesch JB, Kay S. Circadian light input in plants, flies and mammals. Novartis Found Symp. 2003; 253:73-82; discussion 82-8, 102-9, 281-4. PMID: 14712915.
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    122. Hogenesch JB, Panda S, Kay S, Takahashi JS. Circadian transcriptional output in the SCN and liver of the mouse. Novartis Found Symp. 2003; 253:171-80; discussion 52-5, 102-9, 180-3 passim. PMID: 14712921.
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    123. Panda S, Sato TK, Castrucci AM, Rollag MD, DeGrip WJ, Hogenesch JB, Provencio I, Kay S. Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting. Science. 2002 Dec 13; 298(5601):2213-6. PMID: 12481141.
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    124. Beachy R, Bennetzen JL, Chassy BM, Chrispeels M, Chory J, Ecker JR, Noel JP, Kay S, Dean C, Lamb C, Jones J, Santerre CR, Schroeder JI, Umen J, Yanofsky M, Wessler S, Zhao Y, Parrott W. Divergent perspectives on GM food. Nat Biotechnol. 2002 Dec; 20(12):1195-6; author reply 1197. PMID: 12454665.
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    125. Ceriani MF, Hogenesch JB, Yanovsky M, Panda S, Straume M, Kay S. Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior. J Neurosci. 2002 Nov 01; 22(21):9305-19. PMID: 12417656.
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    126. Yanovsky MJ, Kay S. Molecular basis of seasonal time measurement in Arabidopsis. Nature. 2002 Sep 19; 419(6904):308-12. PMID: 12239570.
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    127. Panda S, Poirier GG, Kay S. tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator. Dev Cell. 2002 Jul; 3(1):51-61. PMID: 12110167.
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    128. Panda S, Hogenesch JB, Kay S. Circadian rhythms from flies to human. Nature. 2002 May 16; 417(6886):329-35. PMID: 12015613.
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    129. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay S, Takahashi JS, Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell. 2002 May 03; 109(3):307-20. PMID: 12015981.
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    130. Alabadí D, Yanovsky MJ, Más P, Harmer SL, Kay S. Critical role for CCA1 and LHY in maintaining circadian rhythmicity in Arabidopsis. Curr Biol. 2002 Apr 30; 12(9):757-61. PMID: 12007421.
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    131. Scully AL, Zelhof AC, Kay S. A P element with a novel fusion of reporters identifies regular, a C2H2 zinc-finger gene downstream of the circadian clock. Mol Cell Neurosci. 2002 Apr; 19(4):501-14. PMID: 11988018.
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