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Hidekazu Tsukamoto, PhD

Title(s)Professor of Pathology
Phone+1 323 442 5107
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    Collapse Research 
    Collapse Research Activities and Funding
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH/NIAAA U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    BLR&D Research Career Scientist Award Application
    VA IK6BX004205Apr 1, 2018 - Mar 31, 2025
    Role: Principal Investigator
    Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis
    VA I01BX001991Oct 1, 2013 - Sep 30, 2022
    Role: Principal Investigator
    The dynamics and mechanisms of autophagy in ethanol - induced liver pathogenesis
    NIH/NIAAA R01AA021751Aug 15, 2013 - Jul 31, 2018
    Role: Co-Principal Investigator
    International Symposium of ALPD and Cirrhosis
    NIH/NIAAA R13AA020691Aug 5, 2011 - Apr 30, 2021
    Role: Principal Investigator
    Epigenetic Regulation of Alcoholic Liver Fibrosis
    NIH/NIAAA U01AA018663Sep 1, 2010 - Aug 31, 2020
    Role: Principal Investigator
    15th International Symposium on Cells of the Hepatic Sinusoid
    NIH/NIAAA R13AA019890Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator
    TLR4 and TGF-beta interactions in HCC induced by HCV and alcohol
    NIH/NIAAA RC2AA019392Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    NIH/NIAAA R21AA016682Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    NIH/NIAAA R21AA015162Sep 10, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Integrative Liver Cell Core
    NIH/NIAAA R24AA012885Jun 1, 2001 - May 31, 2021
    Role: Principal Investigator
    NON-PARENCHYMAL LIVER CELL CORE
    NIH/NIAAA R01AA012885Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    Training Program in Alcoholic Liver&Pancreatic Diseases
    NIH/NIAAA T32AA007578May 1, 2000 - Apr 30, 2011
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH/NIAAA P50AA011999Jan 1, 1999 - Dec 31, 2023
    Role: Principal Investigator
    PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH/NIAAA R37AA006603Sep 1, 1991 - Nov 30, 2004
    Role: Principal Investigator
    PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH/NIAAA R01AA006603Jun 1, 1984 - Nov 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Aizawa S, Brar G, Tsukamoto H. Cell Death and Liver Disease. Gut Liver. 2019 Mar 19. PMID: 30917630.
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    2. Gao B, Ahmad MF, Nagy LE, Tsukamoto H. Inflammatory pathways in alcoholic steatohepatitis. J Hepatol. 2019 Feb; 70(2):249-259. PMID: 30658726.
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    3. Brar G, Tsukamoto H. Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science. J Gastroenterol. 2019 Mar; 54(3):218-225. PMID: 30643981.
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    4. Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H. Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology. 2018 11; 68(5):1726-1740. PMID: 29729190.
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    5. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 Aug 28; 4(1):18. PMID: 30154473.
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    6. Kuprys PV, Tsukamoto H, Gao B, Jia L, McGowan J, Coopersmith CM, Moreno MC, Hulsebus H, Meena AS, Souza-Smith FM, Roper P, Foster MT, Raju SV, Marshall SA, Fujita M, Curtis BJ, Wyatt TA, Mandrekar P, Kovacs EJ, Choudhry MA. Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2018 Aug 24; 77:11-18. PMID: 30763905.
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    7. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Alcoholic liver disease. Nat Rev Dis Primers. 2018 Aug 16; 4(1):16. PMID: 30115921.
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    8. Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, Lazaro R, Ansong C, Smith RD, Bataller R, Morgan T, Schnabl B, Tsukamoto H. Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018 05; 67(5):1737-1753. PMID: 29108122.
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    9. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177. PMID: 28942194.
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    10. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1. PLoS One. 2017; 12(8):e0181052. PMID: 28797077.
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    11. McDaniel K, Huang L, Sato K, Wu N, Annable T, Zhou T, Ramos-Lorenzo S, Wan Y, Huang Q, Francis H, Glaser S, Tsukamoto H, Alpini G, Meng F. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem. 2017 07 07; 292(27):11336-11347. PMID: 28536261.
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    12. Yang Z, Liu Y, Qin L, Wu P, Xia Z, Luo M, Zeng Y, Tsukamoto H, Ju Z, Su D, Kang H, Xiao Z, Zheng S, Duan Z, Hu R, Wang Q, Pandol SJ, Han YP. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. Am J Pathol. 2017 Apr; 187(4):781-797. PMID: 28157489.
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    13. Lai KKY, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491. PMID: 28143772.
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    14. Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 01 04; 25(1):218-231. PMID: 28129116.
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    15. Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability. Hepatology. 2017 02; 65(2):678-693. PMID: 28114741.
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    16. Sadio A, Amaral AL, Nunes R, Ricardo S, Sarmento B, Almeida R, Tsukamoto H, das Neves J. A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Front Physiol. 2016; 7:579. PMID: 27965585.
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    17. Su D, Nie Y, Zhu A, Chen Z, Wu P, Zhang L, Luo M, Sun Q, Cai L, Lai Y, Xiao Z, Duan Z, Zheng S, Wu G, Hu R, Tsukamoto H, Lugea A, Liu Z, Pandol SJ, Han YP. Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. Front Physiol. 2016; 7:498. PMID: 27895587.
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    18. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. PMID: 27639178.
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    19. Hasegawa K, Tagawa M, Takagi K, Tsukamoto H, Tomioka Y, Suzuki T, Nishioka Y, Ohrui T, Numasaki M. Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-?2 or IL-29/IFN-?1. Cancer Gene Ther. 2016 08; 23(8):266-77. PMID: 27561689.
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    20. Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. PMID: 27401171; PMCID: PMC5002042.
    21. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-? in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111. PMID: 27214381.
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    22. Mandrekar P, Bataller R, Tsukamoto H, Gao B. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. 2016 10; 64(4):1343-55. PMID: 26940353.
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    23. Puri P, Xu J, Vihervaara T, Katainen R, Ekroos K, Daita K, Min HK, Joyce A, Mirshahi F, Tsukamoto H, Sanyal AJ. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. J Lipid Res. 2016 06; 57(6):1017-28. PMID: 27020313.
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    24. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
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    25. Gao B, Tsukamoto H. Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9. PMID: 26826669.
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    26. Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L. TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016 Feb; 126(2):527-42. PMID: 26784546.
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    27. Adachi N, Adamovitch V, Adjovi Y, Aida K, Akamatsu H, Akiyama S, Akli A, Ando A, Andrault T, Antonietti H, Anzai S, Arkoun G, Avenoso C, Ayrault D, Banasiewicz M, Banaskiewicz M, Bernardini L, Bernard E, Berthet E, Blanchard M, Boreyko D, Boros K, Charron S, Cornette P, Czerkas K, Dameron M, Date I, De Pontbriand M, Demangeau F, Dobaczewski L, Dobrzynski L, Ducouret A, Dziedzic M, Ecalle A, Edon V, Endo K, Endo T, Endo Y, Etryk D, Fabiszewska M, Fang S, Fauchier D, Felici F, Fujiwara Y, Gardais C, Gaul W, Gurin L, Hakoda R, Hamamatsu I, Handa K, Haneda H, Hara T, Hashimoto M, Hashimoto T, Hashimoto K, Hata D, Hattori M, Hayano R, Hayashi R, Higasi H, Hiruta M, Honda A, Horikawa Y, Horiuchi H, Hozumi Y, Ide M, Ihara S, Ikoma T, Inohara Y, Itazu M, Ito A, Janvrin J, Jout I, Kanda H, Kanemori G, Kanno M, Kanomata N, Kato T, Kato S, Katsu J, Kawasaki Y, Kikuchi K, Kilian P, Kimura N, Kiya M, Klepuszewski M, Kluchnikov E, Kodama Y, Kokubun R, Konishi F, Konno A, Kontsevoy V, Koori A, Koutaka A, Kowol A, Koyama Y, Koziol M, Kozue M, Kravtchenko O, Kruczala W, Kudla M, Kudo H, Kumagai R, Kurogome K, Kurosu A, Kuse M, Lacombe A, Lefaillet E, Magara M, Malinowska J, Malinowski M, Maroselli V, Masui Y, Matsukawa K, Matsuya K, Matusik B, Maulny M, Mazur P, Miyake C, Miyamoto Y, Miyata K, Miyata K, Miyazaki M, Mol?da M, Morioka T, Morita E, Muto K, Nadamoto H, Nadzikiewicz M, Nagashima K, Nakade M, Nakayama C, Nakazawa H, Nihei Y, Nikul R, Niwa S, Niwa O, Nogi M, Nomura K, Ogata D, Ohguchi H, Ohno J, Okabe M, Okada M, Okada Y, Omi N, Onodera H, Onodera K, Ooki S, Oonishi K, Oonuma H, Ooshima H, Oouchi H, Orsucci M, Paoli M, Penaud M, Perdrisot C, Petit M, Piskowski A, Plocharski A, Polis A, Polti L, Potsepnia T, Przybylski D, Pytel M, Quillet W, Remy A, Robert C, Sadowski M, Saito M, Sakuma D, Sano K, Sasaki Y, Sato N, Schneider T, Schneider C, Schwartzman K, Selivanov E, Sezaki M, Shiroishi K, Shustava I, Sniecinska A, Stalchenko E, Staron A, Stromboni M, Studzinska W, Sugisaki H, Sukegawa T, Sumida M, Suzuki Y, Suzuki K, Suzuki R, Suzuki H, Suzuki K, Swiderski W, Szudejko M, Szymaszek M, Tada J, Taguchi H, Takahashi K, Tanaka D, Tanaka G, Tanaka S, Tanino K, Tazbir K, Tcesnokova N, Tgawa N, Toda N, Tsuchiya H, Tsukamoto H, Tsushima T, Tsutsumi K, Umemura H, Uno M, Usui A, Utsumi H, Vaucelle M, Wada Y, Watanabe K, Watanabe S, Watase K, Witkowski M, Yamaki T, Yamamoto J, Yamamoto T, Yamashita M, Yanai M, Yasuda K, Yoshida Y, Yoshida A, Yoshimura K, Zmijewska M, Zuclarelli E. Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the 'D-shuttle' project. J Radiol Prot. 2016 Mar; 36(1):49-66. PMID: 26613195.
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    28. Xu J, Chi F, Tsukamoto H. Notch, metabolism and macrophages. Oncotarget. 2015 Aug 21; 6(24):19942-3. PMID: 26343518.
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    29. Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M. Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 2015 Aug; 44(6):882-7. PMID: 26166469.
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    30. Fung E, Tsukamoto H. Morphogen-related therapeutic targets for liver fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. PMID: 26206577.
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    31. Strauss E, Parise ER, Tsukamoto H. ALPD 2015, Preface. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. PMID: 26206575.
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    32. Xu J, Chi F, Tsukamoto H. Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. PMID: 26189984.
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    33. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. PMID: 26198936.
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    34. Lazaro R, Wu R, Tsukamoto H. Reply: To PMID 25132354. Hepatology. 2015 Jul; 62(1):324. PMID: 25302605.
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    35. Xu J, Chi F, Guo T, Punj V, Lee WN, French SW, Tsukamoto H. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest. 2015 Apr; 125(4):1579-90. PMID: 25798621.
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    36. Tsukamoto H. Metabolic reprogramming and cell fate regulation in alcoholic liver disease. Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. PMID: 25800177.
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    37. Machida K, Feldman DE, Tsukamoto H. TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Adv Exp Med Biol. 2015; 815:131-44. PMID: 25427905.
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    38. Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. Low intracellular iron increases the stability of matriptase-2. J Biol Chem. 2015 Feb 13; 290(7):4432-46. PMID: 25550162.
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    39. Lazaro R, Wu R, Lee S, Zhu NL, Chen CL, French SW, Xu J, Machida K, Tsukamoto H. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology. 2015 Jan; 61(1):129-40. PMID: 25132354.
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    40. Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97. PMID: 25457206.
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    41. Chen P, Torralba M, Tan J, Embree M, Zengler K, Stärkel P, van Pijkeren JP, DePew J, Loomba R, Ho SB, Bajaj JS, Mutlu EA, Keshavarzian A, Tsukamoto H, Nelson KE, Fouts DE, Schnabl B. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan; 148(1):203-214.e16. PMID: 25239591.
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    42. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. PMID: 26594598.
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    43. Chen CL, Tsukamoto H, Machida K. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014 Jul; 8(3):330-8. PMID: 26202636.
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    44. Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. PMID: 24730561; PMCID: PMC4047166.
    45. Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014 Mar; 59(3):1118-29. PMID: 24122827.
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    46. Tsukamoto H, Mishra L, Machida K. Alcohol, TLR4-TGF-ß antagonism, and liver cancer. Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. PMID: 26201318.
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    47. Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49. PMID: 23921128.
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    48. Kagawa T, Orii R, Hirose S, Arase Y, Shiraishi K, Mizutani A, Tsukamoto H, Mine T. Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells. J Gastroenterol. 2014 May; 49(5):890-9. PMID: 23722250.
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    49. Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013 Jul; 58(1):108-19. PMID: 23408358; PMCID: PMC3695050.
    50. Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One. 2013; 8(4):e60534. PMID: 23565256.
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    51. Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H. Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3. PMID: 23499284.
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    52. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. PMID: 23086958.
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    53. Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology. 2012 Sep; 56(3):1129-39. PMID: 22488473.
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    54. Huang B, Takahashi K, Sakata-Goto T, Kiso H, Togo Y, Saito K, Tsukamoto H, Sugai M, Akira S, Shimizu A, Bessho K. Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process. Oral Dis. 2013 Mar; 19(2):144-50. PMID: 22849712.
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    55. Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G. Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 2012 Sep; 181(3):804-17. PMID: 22841474.
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    56. Zhong S, Xu J, Li P, Tsukamoto H. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84. PMID: 22829592.
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    57. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. PMID: 22687340; PMCID: PMC3445734.
    58. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629; PMCID: PMC3386114.
    59. Ueno A, Lazaro R, Wang PY, Higashiyama R, Machida K, Tsukamoto H. Mouse intragastric infusion (iG) model. Nat Protoc. 2012 Mar 29; 7(4):771-81. PMID: 22461066.
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    60. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. PMID: 22320911.
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    61. Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. PMID: 22320925.
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    62. Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. PMID: 22095555.
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    63. Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-67. PMID: 22298767.
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    68. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
    69. Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. PMID: 21294146.
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    70. Xu J, Lai KKY, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682. PMID: 21256905.
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    71. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. PMID: 21254165; PMCID: PMC3059122.
    72. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. PMID: 21134374.
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    73. Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood. 2011 Feb 03; 117(5):1687-99. PMID: 21115976.
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    74. Zhong S, Machida K, Tsukamoto H, Johnson DL. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. PMID: 21106530.
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    75. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. PMID: 20683948; PMCID: PMC3107125.
    76. Zhu NL, Wang J, Tsukamoto H. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. J Biol Chem. 2010 Oct 01; 285(40):30463-71. PMID: 20663865.
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    77. Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. PMID: 20427470.
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    78. Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar; 51(3):932-41. PMID: 19957376; PMCID: PMC2898175.
    79. Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Hepatology. 2010 Mar; 51(3):986-95. PMID: 20043323.
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    80. Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol. 2010 Mar; 52(3):407-16. PMID: 20129692.
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    81. Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010 Feb; 138(2):705-14, 714.e1-4. PMID: 19843474.
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    82. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. PMID: 19828633.
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    83. Yeligar S, Tsukamoto H, Kalra VK. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. PMID: 19783678.
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    84. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. PMID: 19444874.
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    85. Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA. Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem. 2009 Aug 21; 284(34):22580-9. PMID: 19564337.
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    86. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. "Second hit" models of alcoholic liver disease. Semin Liver Dis. 2009 May; 29(2):178-87. PMID: 19387917.
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    87. Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009 Mar; 9(3):217-27. PMID: 19254567.
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    88. Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas. 2009 Mar; 38(2):e47-52. PMID: 19248221; PMCID: PMC4662660.
    89. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. PMID: 19085956.
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    90. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. PMID: 19171902; PMCID: PMC2635765.
    91. Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, Kojima S. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology. 2009 May; 136(5):1783-95.e10. PMID: 19208340; PMCID: PMC4960455.
    92. Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R, Nosaka T, Sugita K, Morimoto A, Hayashi Y, Hotta T, Ando K, Miyachi H. C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Oncogene. 2008 Dec 04; 27(53):6749-60. PMID: 18776924.
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    93. Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. PMID: 18782341.
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    94. Mello T, Nakatsuka A, Fears S, Davis W, Tsukamoto H, Bosron WF, Sanghani SP. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. PMID: 18639528.
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    95. Xiong S, She H, Zhang AS, Wang J, Mkrtchyan H, Dynnyk A, Gordeuk VR, French SW, Enns CA, Tsukamoto H. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. PMID: 18599584.
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    97. Tsukamoto H, Mkrtchyan H, Dynnyk A. Intragastric ethanol infusion model in rodents. Methods Mol Biol. 2008; 447:33-48. PMID: 18369909.
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    98. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. PMID: 18006602.
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    99. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. PMID: 17668871; PMCID: PMC3494299.
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    101. Tsukamoto H. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. J Gastroenterol. 2007 Aug; 42(8):603-9. PMID: 17701122.
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    102. Han YP, Yan C, Zhou L, Qin L, Tsukamoto H. A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem. 2007 Apr 27; 282(17):12928-39. PMID: 17322299.
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    103. Chen L, Xiong S, She H, Lin SW, Wang J, Tsukamoto H. Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. J Biol Chem. 2007 Feb 23; 282(8):5582-8. PMID: 17172471.
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    109. Yavrom S, Chen L, Xiong S, Wang J, Rippe RA, Tsukamoto H. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem. 2005 Dec 09; 280(49):40650-9. PMID: 16216869.
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    110. Deng QG, She H, Cheng JH, French SW, Koop DR, Xiong S, Tsukamoto H. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology. 2005 Oct; 42(4):905-14. PMID: 16175602.
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    111. Tsukamoto H, Nagafuji K, Horiuchi T, Miyamoto T, Aoki K, Takase K, Henzan H, Himeji D, Koyama T, Miyake K, Inoue Y, Nakashima H, Otsuka T, Tanaka Y, Nagasawa K, Harada M. A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease. Ann Rheum Dis. 2006 Apr; 65(4):508-14. PMID: 16126798.
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    112. Yang MD, Deng QG, Chen S, Xiong S, Koop D, Tsukamoto H. Hepatoprotective mechanisms of Yan-gan-wan. Hepatol Res. 2005 Aug; 32(4):202-12. PMID: 16107322.
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    113. Sussman S, Runyon BA, Hernandez R, Magallanes M, Mendler M, Yuan JM, Tsukamoto H. A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease. Addict Behav. 2005 Mar; 30(3):465-73. PMID: 15718064.
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    114. She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005 Feb 11; 280(6):4959-67. PMID: 15537655.
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    115. Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. PMID: 15131799.
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    116. Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. PMID: 15064230.
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    117. Xiong S, She H, Tsukamoto H. Signaling role of iron in NF-kappa B activation in hepatic macrophages. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. PMID: 14960188.
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    118. Hazra S, Miyahara T, Rippe RA, Tsukamoto H. PPAR Gamma and Hepatic Stellate Cells. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. PMID: 14960159.
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    119. Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, Chatterjee K, Tsukamoto H. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem. 2004 Mar 19; 279(12):11392-401. PMID: 14702344.
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    120. Sung CK, She H, Xiong S, Tsukamoto H. Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. PMID: 14656714.
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    121. Han YP, Zhou L, Wang J, Xiong S, Garner WL, French SW, Tsukamoto H. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem. 2004 Feb 06; 279(6):4820-8. PMID: 14617627; PMCID: PMC2430939.
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    123. Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 2004 Feb 15; 103(4):1509-14. PMID: 14563638.
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    124. Xiong S, She H, Sung CK, Tsukamoto H. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol. 2003 Jun; 30(2):107-13. PMID: 12957294.
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    125. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. PMID: 12637578.
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    126. Sawabe T, Horiuchi T, Koga R, Tsukamoto H, Kojima T, Harashima S, Kikuchi Y, Otsuka J, Mitoma H, Yoshizawa S, Niho Y, Watanabe T. Aberrant HS1 molecule in a patient with systemic lupus erythematosus. Genes Immun. 2003 Mar; 4(2):122-31. PMID: 12618860.
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    127. Tsukamoto H. Redox regulation of cytokine expression in Kupffer cells. Antioxid Redox Signal. 2002 Oct; 4(5):741-8. PMID: 12470501.
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    128. Neuman MG, Katz GG, Malkiewicz IM, Mathurin P, Tsukamoto H, Adachi M, Ishii H, Colell A, García-Ruiz C, Fernández-Checa JC, Casey CA. Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol. 2002 Oct; 28(2):117-28. PMID: 12457943.
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    129. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. PMID: 12181188.
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    130. Lu SC, Tsukamoto H, Mato JM. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol. 2002 Jul; 27(3):155-62. PMID: 12163143.
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    131. Mathurin P, Xiong S, Kharbanda KK, Veal N, Miyahara T, Motomura K, Rippe RA, Bachem MG, Tsukamoto H. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. PMID: 12016123.
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    132. Tsukamoto H. Iron regulation of hepatic macrophage TNFalpha expression. Free Radic Biol Med. 2002 Feb 15; 32(4):309-13. PMID: 11841920.
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    133. Sussman S, Dent CW, Skara S, de Calice P, Tsukamoto H. Alcoholic liver disease (ALD): a new domain for prevention efforts. Subst Use Misuse. 2002; 37(14):1887-904. PMID: 12511057.
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    134. Morita C, Horiuchi T, Tsukamoto H, Hatta N, Kikuchi Y, Arinobu Y, Otsuka T, Sawabe T, Harashima S, Nagasawa K, Niho Y. Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis. Arthritis Rheum. 2001 Dec; 44(12):2819-27. PMID: 11762942.
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    135. Hishinuma T, Tsukamoto H, Suzuki K, Mizugaki M. Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins Leukot Essent Fatty Acids. 2001 Oct; 65(4):191-6. PMID: 11728171.
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    136. Motomura K, Ohata M, Satre M, Tsukamoto H. Destabilization of TNF-alpha mRNA by retinoic acid in hepatic macrophages: implications for alcoholic liver disease. Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E420-9. PMID: 11500296.
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    137. Yamane T, Kunisada T, Tsukamoto H, Yamazaki H, Niwa H, Takada S, Hayashi SI. Wnt signaling regulates hemopoiesis through stromal cells. J Immunol. 2001 Jul 15; 167(2):765-72. PMID: 11441081.
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    138. Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima SI, Tsuchiya T, Nakano S. Defect of lck in a patient with common variable immunodeficiency. Int J Mol Med. 2001 Jun; 7(6):609-14. PMID: 11351273.
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    139. Tsukamoto H, Lu SC. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J. 2001 Jun; 15(8):1335-49. PMID: 11387231.
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    140. Crabb DW, Pinairs J, Hasanadka R, Fang M, Leo MA, Lieber CS, Tsukamoto H, Motomura K, Miyahara T, Ohata M, Bosron W, Sanghani S, Kedishvili N, Shiraishi H, Yokoyama H, Miyagi M, Ishii H, Bergheim I, Menzl I, Parlesak A, Bode C. Alcohol and retinoids. Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):207S-217S. PMID: 11391073.
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    141. Tsukamoto H, Takei Y, McClain CJ, Joshi-Barve S, Hill D, Schmidt J, Deaciuc I, Barve S, Colell A, Garcia-Ruiz C, Kaplowitz N, Fernandez-Checa JC, Yokoyama H, Okamura Y, Nakamura Y, Ishii H, Chawla RK, Barve S, Joshi-Barve S, Watson W, Nelson W, Lin M, Ohata M, Motomura K, Enomoto N, Ikejima K, Kitamura T, Oide H, Hirose M, Bradford BU, Rivera CA, Kono H, Peter S, Yamashina S, Konno A, Ishikawa M, Shimizu H, Sato N, Thurman R. How is the liver primed or sensitized for alcoholic liver disease? Alcohol Clin Exp Res. 2001 May; 25(5 Suppl ISBRA):171S-181S. PMID: 11391068.
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    142. Rose ML, Bradford BU, Germolec DR, Lin M, Tsukamoto H, Thurman RG. Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha. Toxicol Appl Pharmacol. 2001 Jan 01; 170(1):39-45. PMID: 11141354.
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    143. Harashima S, Horiuchi T, Hatta N, Morita C, Higuchi M, Sawabe T, Tsukamoto H, Tahira T, Hayashi K, Fujita S, Niho Y. Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells. J Immunol. 2001 Jan 01; 166(1):130-6. PMID: 11123285.
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    144. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solís-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. PMID: 11093957.
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    145. Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF, Motomura K, Anania FA, Willson TM, Tsukamoto H. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem. 2000 Nov 17; 275(46):35715-22. PMID: 10969082.
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    146. Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H. Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology. 2000 Nov; 32(5):1008-17. PMID: 11050051.
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    147. Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. PMID: 10898761.
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    148. Tsukamoto H. Cyp2e1 and ALD. Hepatology. 2000 Jul; 32(1):154-6. PMID: 10869305.
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    149. Horiuchi T, Himeji D, Tsukamoto H, Harashima S, Hashimura C, Hayashi K. Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. PMID: 10860845.
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    150. Ohata M, Yamauchi M, Takeda K, Toda G, Kamimura S, Motomura K, Xiong S, Tsukamoto H. RAR and RXR expression by Kupffer cells. Exp Mol Pathol. 2000 Feb; 68(1):13-20. PMID: 10640450.
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    151. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am J Physiol. 1999 12; 277(6):G1240-50. PMID: 10600822.
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    152. Lu SC, Huang ZZ, Yang H, Tsukamoto H. Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat. Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. PMID: 10486302.
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    153. Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Zong Y, Solomon TE, Gukovskaya AS, Tsukamoto H. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. Gastroenterology. 1999 Sep; 117(3):706-16. PMID: 10464148.
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    154. Lu SC, Huang ZZ, Yang JM, Tsukamoto H. Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat. Hepatology. 1999 Jul; 30(1):209-14. PMID: 10385658.
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    155. Tsukamoto H. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin Exp Res. 1999 May; 23(5):911-6. PMID: 10371413.
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    156. Nagata N, Watanabe N, Tsuda M, Tsukamoto H, Matsuzaki S. Relationship between serum levels of anti-low-density lipoprotein-acetaldehyde-adduct antibody and aldehyde dehydrogenase 2 heterozygotes in patients with alcoholic liver injury. Alcohol Clin Exp Res. 1999 Apr; 23(4 Suppl):24S-28S. PMID: 10235274.
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    157. Tsukamoto H. Is interleukin-10 antifibrogenic in chronic liver injury? Hepatology. 1998 Dec; 28(6):1707-9. PMID: 9828239.
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    158. Boado RJ, Tsukamoto H, Pardridge WM. Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. J Pharm Sci. 1998 Nov; 87(11):1308-15. PMID: 9811482.
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    159. Cheng XJ, Tsukamoto H, Kaneda Y, Tachibana H. Identification of the 150-kDa surface antigen of Entamoeba histolytica as a galactose- and N-acetyl-D-galactosamine-inhibitable lectin. Parasitol Res. 1998 Aug; 84(8):632-9. PMID: 9747935.
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    160. Tsukamoto H. Molecular mechanism of induced hepatic macrophage cytokine gene expression in experimental alcoholic liver injury. Alcohol Clin Exp Res. 1998 Aug; 22(5 Suppl):253S-254S. PMID: 9727646.
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    161. Tsukamoto H, Hamada Y, Wu D, Boado RJ, Pardridge WM. GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues. Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):170-7. PMID: 9685631.
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    162. Rusyn I, Tsukamoto H, Thurman RG. WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes. Carcinogenesis. 1998 Jul; 19(7):1217-22. PMID: 9683180.
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    163. Yano N, Asakura K, Endoh M, Abe Y, Nomoto Y, Sakai H, Kurokawa K, Tsukamoto H. Polymorphism in the Ialpha1 germ-line transcript regulatory region and IgA productivity in patients with IgA nephropathy. J Immunol. 1998 May 15; 160(10):4936-42. PMID: 9590241.
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    164. Katsumi A, Kojima T, Senda T, Yamazaki T, Tsukamoto H, Sugiura I, Kobayashi S, Miyata T, Umeyama H, Saito H. The carboxyl-terminal region of protein C is essential for its secretion. Blood. 1998 May 15; 91(10):3784-91. PMID: 9573015.
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    165. Kikuchi S, Tsukamoto H, Mieno H, Sato K, Kobayashi N, Shimao H, Sakakibara Y, Hiki Y, Kakita A. Results of resection of gastric cancer with distant metastases. Hepatogastroenterology. 1998 Mar-Apr; 45(20):592-6. PMID: 9638458.
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    166. Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem. 1998 Jan 02; 273(1):302-8. PMID: 9417080.
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    167. Lin M, Rippe RA, Niemelä O, Brittenham G, Tsukamoto H. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1355-64. PMID: 9227470.
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    168. Tsukamoto H, Boado RJ, Pardridge WM. Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression. J Neurochem. 1997 Jun; 68(6):2587-92. PMID: 9166756.
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    169. Horne WI, Tandler B, Dubick MA, Niemelä O, Brittenham GM, Tsukamoto H. Iron overload in the rat pancreas following portacaval shunting and dietary iron supplementation. Exp Mol Pathol. 1997 Apr; 64(2):90-102. PMID: 9316587.
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    170. Ohata M, Lin M, Satre M, Tsukamoto H. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol. 1997 Mar; 272(3 Pt 1):G589-96. PMID: 9124579.
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    171. Yanagisawa J, Tsuda M, Ohkubo T, Hiyoshi M, Kamiguchi H, Tsukamoto H, Yamamura M, Kocha T, Aoyagi T. A new type of major aminopeptidase in bovine brain. Biochem Mol Med. 1996 Dec; 59(2):161-8. PMID: 8986639.
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    172. Boado RJ, Tsukamoto H, Pardridge WM. Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA. J Neurochem. 1996 Oct; 67(4):1335-43. PMID: 8858913.
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    173. Wang SC, Tsukamoto H, Brenner DA, Rippe RA. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 1996 Sep; 24(3):670-6. PMID: 8781341.
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    174. Tsukamoto H, Tousson A, Marchase RB, Volanakis JE. Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA. J Immunol. 1996 Jun 15; 156(12):4901-8. PMID: 8648140.
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    175. Tsukamoto H, Boado RJ, Pardridge WM. Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. J Clin Invest. 1996 Jun 15; 97(12):2823-32. PMID: 8675694.
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    176. Tandler B, Horne WI, Brittenham GM, Tsukamoto H. Giant mitochondria induced in rat pancreatic exocrine cells by ethanol and iron. Anat Rec. 1996 May; 245(1):65-75. PMID: 8731042.
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    177. Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, Nakazawa H. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res. 1996 May; 24(5):361-7. PMID: 8733940.
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    178. Tsukamoto H, Cheng S, Blaner WS. Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation. Am J Physiol. 1996 Apr; 270(4 Pt 1):G581-6. PMID: 8928787.
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    179. Sakai N, Inui K, Tatsumi N, Fukushima H, Nishigaki T, Taniike M, Nishimoto J, Tsukamoto H, Yanagihara I, Ozono K, Okada S. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. J Neurochem. 1996 Mar; 66(3):1118-24. PMID: 8769874.
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    180. Ohwada M, Suzuki M, Sato I, Tsukamoto H, Watanabe K. Glutathione peroxidase activity in endometrium: effects of sex hormones and cancer. Gynecol Oncol. 1996 Feb; 60(2):277-82. PMID: 8631551.
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    181. Kaplowitz N, Tsukamoto H. Oxidative stress and liver disease. Prog Liver Dis. 1996; 14:131-59. PMID: 9055577.
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    182. Kamimura S, Tsukamoto H. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology. 1995 Oct; 22(4 Pt 1):1304-9. PMID: 7557885.
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    183. Tatsumi N, Inui K, Sakai N, Fukushima H, Nishimoto J, Yanagihara I, Nishigaki T, Tsukamoto H, Fu L, Taniike M. Molecular defects in Krabbe disease. Hum Mol Genet. 1995 Oct; 4(10):1865-8. PMID: 8595408.
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    184. Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, Brittenham GM. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 1995 Jul; 96(1):620-30. PMID: 7615836.
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    185. Kaysen GA, Sun X, Jones H, Martin VI, Joles JA, Tsukamoto H, Couser WG, al-Bander H. Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat. Kidney Int. 1995 Apr; 47(4):1068-77. PMID: 7783403.
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    186. Hattori K, Tsukamoto H, Ohta S, Yabe M, Yabe H, Kato S, Takakura I, Ueda R, Habu S, Nishimura T. Bispecific antibody-mediated cytotoxicity by CD4+ and CD8(+)-activated T cells generated from leukemia patients after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1995 Feb; 15(2):193-8. PMID: 7773208.
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    187. Ohta S, Tsukamoto H, Watanabe K, Makino K, Kuge S, Hanai N, Habu S, Nishimura T. Tumor-associated glycoantigen, sialyl Lewis(a) as a target for bispecific antibody-directed adoptive tumor immunotherapy. Immunol Lett. 1995 Jan; 44(1):35-40. PMID: 7721341.
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    188. Tsukamoto H, Rippe R, Niemelä O, Lin M. Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis. J Gastroenterol Hepatol. 1995; 10 Suppl 1:S50-3. PMID: 8589343.
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    189. Moriyama A, Shimamura R, Igarashi H, Tsukamoto H, Takii M, Okubo H, Toyoshima S. [A case of nodular regenerative hyperplasia (NRH) of the liver associated with recurrent hepatic encephalopathy due to splenorenal shunt]. Nihon Shokakibyo Gakkai Zasshi. 1994 Jun; 91(6):1136-40. PMID: 8028207.
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    190. Horne WI, Tsukamoto H. Dietary modulation of alcohol-induced pancreatic injury. Alcohol. 1993 Nov-Dec; 10(6):481-4. PMID: 8123204.
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    191. Tsukamoto H, French SW. Evolution of intragastric ethanol infusion model. Alcohol. 1993 Nov-Dec; 10(6):437-41. PMID: 8123196.
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    192. Fernández-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 1993 Nov-Dec; 10(6):469-75. PMID: 8123202.
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    193. Tsukamoto H. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis. Alcohol. 1993 Nov-Dec; 10(6):465-7. PMID: 8123201.
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    194. Tsukamoto H, Nakamura Y, Masuko T, Hashimoto Y, Habu S, Nishimura T. Specific targeting of in vitro-activated human antitumour effector cells using anti-CD3 x anti-c-erbB-2 bispecific antibody. Immunol Cell Biol. 1993 Apr; 71 ( Pt 2):109-15. PMID: 8098011.
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    195. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 1992 Dec; 16(6):1423-7. PMID: 1446896.
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    196. Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology. 1992 Oct; 16(4):992-6. PMID: 1398507.
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    197. Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology. 1992 Aug; 16(2):448-53. PMID: 1639354.
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    198. Taniike M, Fukushima H, Yanagihara I, Tsukamoto H, Tanaka J, Fujimura H, Nagai T, Sano T, Yamaoka K, Inui K. Mitochondrial tRNA(Ile) mutation in fatal cardiomyopathy. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):47-53. PMID: 1632786.
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    199. Nakamura Y, Tokuda Y, Iwasawa M, Tsukamoto H, Kidokoro M, Kobayashi N, Kato S, Mitomi T, Habu S, Nishimura T. Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumour immunotherapy. Br J Cancer. 1992 Jul; 66(1):20-6. PMID: 1353365.
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    200. Smith SM, Tsukamoto H. Time dependency of IgA nephropathy induction in alcohol ingestion. Alcohol Clin Exp Res. 1992 Jun; 16(3):471-3. PMID: 1626647.
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    201. Nishimura T, Nakamura Y, Tsukamoto H, Takeuchi Y, Tokuda Y, Iwasawa M, Yamamoto T, Masuko T, Hashimoto Y, Habu S. Human c-erbB-2 proto-oncogene product as a target for bispecific-antibody-directed adoptive tumor immunotherapy. Int J Cancer. 1992 Mar 12; 50(5):800-4. PMID: 1347516.
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    202. Kawashima I, Sakabe K, Seiki K, Fujii-Hanamoto H, Akatsuka A, Tsukamoto H. Localization of sex steroid receptor cells, with special reference to thymulin (FTS)-producing cells in female rat thymus. Thymus. 1991 Sep; 18(2):79-93. PMID: 1926294.
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    203. Tauchi K, Tsutsumi Y, Tsukamoto H, Hasegawa H, Yoshimura S, Watanabe K. Glutathione peroxidase and glutathione S-transferase, class alpha, in rat intestine. Immunohistochemical and immunoblotting studies on changes in expression of these antilipoperoxidative enzymes during normal development. Acta Pathol Jpn. 1991 Aug; 41(8):573-80. PMID: 1750355.
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    204. Tsukamoto H, Gaal K, French SW. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology. 1990 Sep; 12(3 Pt 1):599-608. PMID: 2205558.
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    205. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 1990 Apr; 11(4):599-605. PMID: 2328954.
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    206. Smith SM, Yu GS, Tsukamoto H. IgA nephropathy in alcohol abuse. An animal model. Lab Invest. 1990 Feb; 62(2):179-84. PMID: 2304330.
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    207. Tsukamoto H, Matsuoka M, French SW. Experimental models of hepatic fibrosis: a review. Semin Liver Dis. 1990 Feb; 10(1):56-65. PMID: 2110685.
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    208. Matsuoka M, Zhang MY, Tsukamoto H. Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis. Hepatology. 1990 Feb; 11(2):173-82. PMID: 2307396.
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    209. French SW, Tsukamoto H. Animal models for alcoholic liver disease. Hepatology. 1989 Nov; 10(5):898-9. PMID: 2807174.
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    210. Nanji AA, Tsukamoto H, French SW. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease. Exp Mol Pathol. 1989 Oct; 51(2):141-8. PMID: 2806468.
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    211. Matsuoka M, Pham NT, Tsukamoto H. Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 1989 Apr; 9(2):71-8. PMID: 2785237.
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    212. Tsukamoto H, Xi XP. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. Hepatology. 1989 Feb; 9(2):302-6. PMID: 2912830.
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    213. Tsukamoto H, Otsuki M, Baba S, Mizoi Y. [Abnormal cholecystokinin-acinar function coupling in atrophied pancreatic acini from rats fed ethanol and a high-fat diet]. Arukoru Kenkyuto Yakubutsu Ison. 1988 Dec; 23(4):332-50. PMID: 2472128.
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    214. Tsukamoto H, Towner SJ, Yu GS, French SW. Potentiation of ethanol-induced pancreatic injury by dietary fat. Induction of chronic pancreatitis by alcohol in rats. Am J Pathol. 1988 May; 131(2):246-57. PMID: 3358454.
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    215. Inomata T, Rao GA, Tsukamoto H. Lack of evidence for increased lipid peroxidation in ethanol-induced centrilobular necrosis of rat liver. Liver. 1987 Aug; 7(4):233-9. PMID: 3683096.
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    216. Tsukamoto H, Sankaran H, Delgado G, Reidelberger RD, Deveney CW, Largman C. Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats. Biochem Pharmacol. 1986 Oct 15; 35(20):3623-9. PMID: 3768045.
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    217. Tsukamoto H, Towner SJ, Ciofalo LM, French SW. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology. 1986 Sep-Oct; 6(5):814-22. PMID: 3758935.
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    218. French SW, Miyamoto K, Tsukamoto H. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res. 1986; 10(6 Suppl):13S-19S. PMID: 3544925.
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    219. Usui H, Yoshikawa K, Imazu M, Tsukamoto H, Takeda M. Comparison of tyrosine phosphorylation of proteins by membrane fractions from mouse liver, Ehrlich ascites tumor and MH134 hepatoma. FEBS Lett. 1985 May 06; 184(1):60-4. PMID: 3872813.
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    220. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, Largman C. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology. 1985 Mar-Apr; 5(2):224-32. PMID: 3979954.
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    221. Tsukamoto H, French SW, Reidelberger RD, Largman C. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcohol Clin Exp Res. 1985 Jan-Feb; 9(1):31-7. PMID: 3887966.
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    222. Tsukamoto H, Reidelberger RD, French SW, Largman C. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol. 1984 Sep; 247(3 Pt 2):R595-9. PMID: 6433728.
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    223. Tsukamoto H, Lew G, Larkin EC, Largman C, Rao GA. Hepatic origin of triglycerides in fatty livers produced by the continuous intragastric infusion of an ethanol diet. Lipids. 1984 Jun; 19(6):419-22. PMID: 6738318.
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    224. Matsumoto T, Kitamura T, Abe H, Tsukamoto H. [Studies on the direct extraction method for determination of lead in blood by atomic absorption spectrophotometry (author's transl)]. Rinsho Byori. 1978 Jul; 26(7):611-4. PMID: 713098.
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