Hidekazu Tsukamoto, PhD

Title(s)Professor of Pathology
SchoolKeck School of Medicine of Usc
AddressMMR 1333 San Pablo St
Health Sciences Campus
Los Angeles CA 90089-9141
Phone+1 323 442 5107
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    Collapse Research 
    Collapse Research Activities and Funding
    Hepatocyte-derived extracellular vesicles in alcoholic liver disease
    NIH R01AA028134Jul 1, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    Immunosuppressive mechanisms responsible for development of non-viral liver cancer and control of its response to immune checkpoint inhibitors
    NIH U01AA027681Sep 25, 2018 - Aug 31, 2023
    Role: Co-Principal Investigator
    BLR&D Research Career Scientist Award Application
    NIH IK6BX004205Apr 1, 2018 - Mar 31, 2025
    Role: Principal Investigator
    Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis
    NIH I01BX001991Oct 1, 2013 - Sep 30, 2022
    Role: Principal Investigator
    The dynamics and mechanisms of autophagy in ethanol - induced liver pathogenesis
    NIH R01AA021751Aug 15, 2013 - Jul 31, 2019
    Role: Co-Principal Investigator
    International Symposium of ALPD and Cirrhosis
    NIH R13AA020691Aug 5, 2011 - Jul 31, 2021
    Role: Principal Investigator
    Epigenetic Regulation of Alcoholic Liver Fibrosis
    NIH U01AA018663Sep 1, 2010 - Aug 31, 2021
    Role: Principal Investigator
    15th International Symposium on Cells of the Hepatic Sinusoid
    NIH R13AA019890Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator
    TLR4 and TGF-beta interactions in HCC induced by HCV and alcohol
    NIH RC2AA019392Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    NIH R21AA016682Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    NIH R21AA015162Sep 10, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Integrative Liver Cell Core
    NIH R24AA012885Jun 1, 2001 - May 31, 2026
    Role: Principal Investigator
    NIH R01AA012885Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    Training Program in Alcoholic Liver&Pancreatic Diseases
    NIH T32AA007578May 1, 2000 - Apr 30, 2011
    Role: Principal Investigator
    The Southern California Research Center for ALPD and Cirrhosis
    NIH P50AA011999Jan 1, 1999 - Dec 31, 2023
    Role: Principal Investigator
    NIH R37AA006603Sep 1, 1991 - Nov 30, 2004
    Role: Principal Investigator
    NIH R01AA006603Jun 1, 1984 - Nov 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. NOTCH localizes to mitochondria through the TBC1D15-FIS1 interaction and is stabilized via blockade of E3 ligase and CDK8 recruitment to reprogram tumor-initiating cells. Exp Mol Med. 2024 Feb; 56(2):461-477. Choi HY, Zhu Y, Zhao X, Mehta S, Hernandez JC, Lee JJ, Kou Y, Machida R, Giacca M, Del Sal G, Ray R, Eoh H, Tahara SM, Chen L, Tsukamoto H, Machida K. PMID: 38409448; PMCID: PMC10907578.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis. Redox Biol. 2024 Apr; 70:103052. Gutierrez V, Kim-Vasquez D, Shum M, Yang Q, Dikeman D, Louie SG, Shirihai OS, Tsukamoto H, Liesa M. PMID: 38290384; PMCID: PMC10844117.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Protocol for generation of humanized HCC mouse model and cancer-driver mutations using CRISPR-Cas9. STAR Protoc. 2023 Dec 08; 4(4):102389. Zhu Y, Tahara SM, Tsukamoto H, Machida K. PMID: 38103196; PMCID: PMC10751556.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. iScience. 2023 Jul 21; 26(7):107035. Yeh DW, Liu C, Hernandez JC, Tahara SM, Tsukamoto H, Machida K. PMID: 37448562; PMCID: PMC10336160.
      View in: PubMed   Mentions: 1  
    5. Hepatic stellate cell stearoyl co-A desaturase activates leukotriene B4 receptor 2 - β-catenin cascade to promote liver tumorigenesis. Nat Commun. 2023 05 08; 14(1):2651. Sinha S, Aizawa S, Nakano Y, Rialdi A, Choi HY, Shrestha R, Pan SQ, Chen Y, Li M, Kapelanski-Lamoureux A, Yochum G, Sher L, Monga SP, Lazaris A, Machida K, Karin M, Guccione E, Tsukamoto H. PMID: 37156770; PMCID: PMC10167314.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury. Hepatol Commun. 2023 04 01; 7(4). Wan Y, Slevin E, Koyama S, Huang CK, Shetty AK, Li X, Harrison K, Li T, Zhou B, Lorenzo SR, Zhang Y, Salinas JM, Xu W, Klaunig JE, Wu C, Tsukamoto H, Meng F. PMID: 37026704; PMCID: PMC10079357.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. LIN28 and histone H3K4 methylase induce TLR4 to generate tumor-initiating stem-like cells. iScience. 2023 Mar 17; 26(3):106254. Hernandez JC, Chen CL, Machida T, Uthaya Kumar DB, Tahara SM, Montana J, Sher L, Liang J, Jung JU, Tsukamoto H, Machida K. PMID: 36949755; PMCID: PMC10025994.
      View in: PubMed   Mentions:
    8. Circadian regulator BMAL1::CLOCK promotes cell proliferation in hepatocellular carcinoma by controlling apoptosis and cell cycle. Proc Natl Acad Sci U S A. 2023 01 10; 120(2):e2214829120. Qu M, Zhang G, Qu H, Vu A, Wu R, Tsukamoto H, Jia Z, Huang W, Lenz HJ, Rich JN, Kay SA. PMID: 36595671; PMCID: PMC9926257.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    9. Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis. Hepatology. 2023 07 01; 78(1):212-224. Balog S, Fujiwara R, Pan SQ, El-Baradie KB, Choi HY, Sinha S, Yang Q, Asahina K, Chen Y, Li M, Salomon M, Ng SW, Tsukamoto H. PMID: 36181700; PMCID: PMC10977045.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    10. Acetate reprograms gut microbiota during alcohol consumption. Nat Commun. 2022 08 08; 13(1):4630. Martino C, Zaramela LS, Gao B, Embree M, Tarasova J, Parker SJ, Wang Y, Chu H, Chen P, Lee KC, Galzerani DD, Gengatharan JM, Lekbua A, Neal M, Knight R, Tsukamoto H, Metallo CM, Schnabl B, Zengler K. PMID: 35941112; PMCID: PMC9359997.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    11. Cell-to-Cell Communications in Alcohol-Associated Liver Disease. Front Physiol. 2022; 13:831004. Osna NA, Eguchi A, Feldstein AE, Tsukamoto H, Dagur RS, Ganesan M, New-Aaron M, Arumugam MK, Chava S, Ribeiro M, Szabo G, Mueller S, Wang S, Chen C, Weinman SA, Kharbanda KK. PMID: 35264978; PMCID: PMC8899290.
      View in: PubMed   Mentions: 8  
    12. Concomitant genetic defects potentiate the adverse impact of prenatal alcohol exposure on cardiac outflow tract maturation. Birth Defects Res. 2022 02; 114(3-4):105-115. Harvey DC, De Zoysa P, Toubat O, Choi J, Kishore J, Tsukamoto H, Kumar SR. PMID: 34859965; PMCID: PMC10033225.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    13. Fate and functional roles of Prominin 1+ cells in liver injury and cancer. Sci Rep. 2020 11 10; 10(1):19412. Wu R, Pan S, Chen Y, Nakano Y, Li M, Balog S, Tsukamoto H. PMID: 33173221; PMCID: PMC7656457.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    14. The 14th International Symposium on Alcoholic Liver and Pancreatic Diseases and Cirrhosis (ISALPDC). Clin Mol Hepatol. 2020 10; 26(4):584-585. Kim DJ, Jeong WI, Tsukamoto H, Gao B. PMID: 33053933; PMCID: PMC7641558.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    15. Comprehensive characterization of hepatocyte-derived extracellular vesicles identifies direct miRNA-based regulation of hepatic stellate cells and DAMP-based hepatic macrophage IL-1β and IL-17 upregulation in alcoholic hepatitis mice. J Mol Med (Berl). 2020 07; 98(7):1021-1034. Eguchi A, Yan R, Pan SQ, Wu R, Kim J, Chen Y, Ansong C, Smith RD, Tempaku M, Ohno-Machado L, Takei Y, Feldstein AE, Tsukamoto H. PMID: 32556367; PMCID: PMC7810220.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    16. p53 destabilizing protein skews asymmetric division and enhances NOTCH activation to direct self-renewal of TICs. Nat Commun. 2020 06 17; 11(1):3084. Choi HY, Siddique HR, Zheng M, Kou Y, Yeh DW, Machida T, Chen CL, Uthaya Kumar DB, Punj V, Winer P, Pita A, Sher L, Tahara SM, Ray RB, Liang C, Chen L, Tsukamoto H, Machida K. PMID: 32555153; PMCID: PMC7299990.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    17. Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol-Related Liver Disease. Alcohol Clin Exp Res. 2020 05; 44(5):1061-1074. Marrero I, Maricic I, Morgan TR, Stolz AA, Schnabl B, Liu ZX, Tsukamoto H, Kumar V. PMID: 32154597; PMCID: PMC7211132.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    18. Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. J Clin Invest. 2020 04 01; 130(4):2129-2145. Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A, Diehl AM. PMID: 31945016; PMCID: PMC7108908.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    19. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. JCI Insight. 2020 02 13; 5(3). Xu J, Ma HY, Liu X, Rosenthal S, Baglieri J, McCubbin R, Sun M, Koyama Y, Geoffroy CG, Saijo K, Shang L, Nishio T, Maricic I, Kreifeldt M, Kusumanchi P, Roberts A, Zheng B, Kumar V, Zengler K, Pizzo DP, Hosseini M, Contet C, Glass CK, Liangpunsakul S, Tsukamoto H, Gao B, Karin M, Brenner DA, Koob GF, Kisseleva T. PMID: 32051339; PMCID: PMC7098802.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    20. Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. Hepatol Commun. 2020 Apr; 4(4):606-626. Liu X, Rosenthal SB, Meshgin N, Baglieri J, Musallam SG, Diggle K, Lam K, Wu R, Pan SQ, Chen Y, Dorko K, Presnell S, Benner C, Hosseini M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 32258954; PMCID: PMC7109347.
      View in: PubMed   Mentions: 10     Fields:    
    21. Cell Death and Liver Disease. Gut Liver. 2020 01 15; 14(1):20-29. Aizawa S, Brar G, Tsukamoto H. PMID: 30917630; PMCID: PMC6974333.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    22. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
      View in: PubMed   Mentions: 69     Fields:    Translation:HumansAnimalsCells
    23. Stearoyl-CoA desaturase and tumorigenesis. Chem Biol Interact. 2020 Jan 25; 316:108917. Kikuchi K, Tsukamoto H. PMID: 31838050; PMCID: PMC6952240.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimalsCells
    24. Moderate alcohol intake promotes pancreatic ductal adenocarcinoma development in mice expressing oncogenic Kras. Am J Physiol Gastrointest Liver Physiol. 2020 02 01; 318(2):G265-G276. Asahina K, Balog S, Hwang E, Moon E, Wan E, Skrypek K, Chen Y, Fernandez J, Romo J, Yang Q, Lai K, French SW, Tsukamoto H. PMID: 31760766; PMCID: PMC7052574.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    25. Inflammatory pathways in alcoholic steatohepatitis. J Hepatol. 2019 02; 70(2):249-259. Gao B, Ahmad MF, Nagy LE, Tsukamoto H. PMID: 30658726; PMCID: PMC6361545.
      View in: PubMed   Mentions: 127     Fields:    Translation:HumansAnimalsCells
    26. Alcoholic and non-alcoholic steatohepatitis: global perspective and emerging science. J Gastroenterol. 2019 Mar; 54(3):218-225. Brar G, Tsukamoto H. PMID: 30643981; PMCID: PMC6394716.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    27. Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology. 2018 11; 68(5):1726-1740. Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H. PMID: 29729190; PMCID: PMC6204108.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 28; 4(1):18. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. PMID: 30154473.
      View in: PubMed   Mentions: 9     Fields:    
    29. Summary of the 2018 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2019 06; 77:11-18. Kuprys PV, Tsukamoto H, Gao B, Jia L, McGowan J, Coopersmith CM, Moreno MC, Hulsebus H, Meena AS, Souza-Smith FM, Roper P, Foster MT, Raju SV, Marshall SA, Fujita M, Curtis BJ, Wyatt TA, Mandrekar P, Kovacs EJ, Choudhry MA. PMID: 30763905; PMCID: PMC6733262.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    30. Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 16; 4(1):16. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. PMID: 30115921.
      View in: PubMed   Mentions: 362     Fields:    Translation:Humans
    31. Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018 05; 67(5):1737-1753. Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, Lazaro R, Ansong C, Smith RD, Bataller R, Morgan T, Schnabl B, Tsukamoto H. PMID: 29108122; PMCID: PMC5906140.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    32. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 04; 14:164-177. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. PMID: 28942194; PMCID: PMC5609874.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    33. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. PLoS One. 2017; 12(8):e0181052. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. PMID: 28797077; PMCID: PMC5552280.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    34. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem. 2017 07 07; 292(27):11336-11347. McDaniel K, Huang L, Sato K, Wu N, Annable T, Zhou T, Ramos-Lorenzo S, Wan Y, Huang Q, Francis H, Glaser S, Tsukamoto H, Alpini G, Meng F. PMID: 28536261; PMCID: PMC5500799.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    35. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. Am J Pathol. 2017 Apr; 187(4):781-797. Yang Z, Liu Y, Qin L, Wu P, Xia Z, Luo M, Zeng Y, Tsukamoto H, Ju Z, Su D, Kang H, Xiao Z, Zheng S, Duan Z, Hu R, Wang Q, Pandol SJ, Han YP. PMID: 28157489; PMCID: PMC5397721.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    36. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491. Lai KKY, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. PMID: 28143772; PMCID: PMC5406249.
      View in: PubMed   Mentions: 84     Fields:    Translation:HumansAnimalsCells
    37. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 01 04; 25(1):218-231. Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. PMID: 28129116; PMCID: PMC5363305.
      View in: PubMed   Mentions: 42     Fields:    Translation:AnimalsCells
    38. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology. 2017 02; 65(2):678-693. Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. PMID: 28114741; PMCID: PMC5432427.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    39. A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Front Physiol. 2016; 7:579. Sadio A, Amaral AL, Nunes R, Ricardo S, Sarmento B, Almeida R, Tsukamoto H, das Neves J. PMID: 27965585; PMCID: PMC5126386.
      View in: PubMed   Mentions: 1  
    40. Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. Front Physiol. 2016; 7:498. Su D, Nie Y, Zhu A, Chen Z, Wu P, Zhang L, Luo M, Sun Q, Cai L, Lai Y, Xiao Z, Duan Z, Zheng S, Wu G, Hu R, Tsukamoto H, Lugea A, Liu Z, Pandol SJ, Han YP. PMID: 27895587; PMCID: PMC5108805.
      View in: PubMed   Mentions: 83  
    41. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. PMID: 27639178; PMCID: PMC5407075.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansAnimalsCells
    42. Anti-tumor immunity elicited by direct intratumoral administration of a recombinant adenovirus expressing either IL-28A/IFN-λ2 or IL-29/IFN-λ1. Cancer Gene Ther. 2016 Aug; 23(8):266-77. Hasegawa K, Tagawa M, Takagi K, Tsukamoto H, Tomioka Y, Suzuki T, Nishioka Y, Ohrui T, Numasaki M. PMID: 27561689.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    43. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. PMID: 27401171; PMCID: PMC5002042.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    44. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-γ in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. PMID: 27214381; PMCID: PMC4877088.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    45. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. 2016 10; 64(4):1343-55. Mandrekar P, Bataller R, Tsukamoto H, Gao B. PMID: 26940353; PMCID: PMC5010788.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansAnimals
    46. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. J Lipid Res. 2016 06; 57(6):1017-28. Puri P, Xu J, Vihervaara T, Katainen R, Ekroos K, Daita K, Min HK, Joyce A, Mirshahi F, Tsukamoto H, Sanyal AJ. PMID: 27020313; PMCID: PMC4878186.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    47. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. PMID: 27239399; PMCID: PMC4878828.
      View in: PubMed   Mentions: 15  
    48. Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9. Gao B, Tsukamoto H. PMID: 26826669; PMCID: PMC4887345.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    49. TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016 Feb; 126(2):527-42. Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L. PMID: 26784546; PMCID: PMC4731168.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    50. Measurement and comparison of individual external doses of high-school students living in Japan, France, Poland and Belarus-the 'D-shuttle' project. J Radiol Prot. 2016 Mar; 36(1):49-66. Adachi N, Adamovitch V, Adjovi Y, Aida K, Akamatsu H, Akiyama S, Akli A, Ando A, Andrault T, Antonietti H, Anzai S, Arkoun G, Avenoso C, Ayrault D, Banasiewicz M, Banaskiewicz M, Bernardini L, Bernard E, Berthet E, Blanchard M, Boreyko D, Boros K, Charron S, Cornette P, Czerkas K, Dameron M, Date I, De Pontbriand M, Demangeau F, Dobaczewski L, Dobrzynski L, Ducouret A, Dziedzic M, Ecalle A, Edon V, Endo K, Endo T, Endo Y, Etryk D, Fabiszewska M, Fang S, Fauchier D, Felici F, Fujiwara Y, Gardais C, Gaul W, Gurin L, Hakoda R, Hamamatsu I, Handa K, Haneda H, Hara T, Hashimoto M, Hashimoto T, Hashimoto K, Hata D, Hattori M, Hayano R, Hayashi R, Higasi H, Hiruta M, Honda A, Horikawa Y, Horiuchi H, Hozumi Y, Ide M, Ihara S, Ikoma T, Inohara Y, Itazu M, Ito A, Janvrin J, Jout I, Kanda H, Kanemori G, Kanno M, Kanomata N, Kato T, Kato S, Katsu J, Kawasaki Y, Kikuchi K, Kilian P, Kimura N, Kiya M, Klepuszewski M, Kluchnikov E, Kodama Y, Kokubun R, Konishi F, Konno A, Kontsevoy V, Koori A, Koutaka A, Kowol A, Koyama Y, Koziol M, Kozue M, Kravtchenko O, Kruczala W, Kudla M, Kudo H, Kumagai R, Kurogome K, Kurosu A, Kuse M, Lacombe A, Lefaillet E, Magara M, Malinowska J, Malinowski M, Maroselli V, Masui Y, Matsukawa K, Matsuya K, Matusik B, Maulny M, Mazur P, Miyake C, Miyamoto Y, Miyata K, Miyata K, Miyazaki M, Mol?da M, Morioka T, Morita E, Muto K, Nadamoto H, Nadzikiewicz M, Nagashima K, Nakade M, Nakayama C, Nakazawa H, Nihei Y, Nikul R, Niwa S, Niwa O, Nogi M, Nomura K, Ogata D, Ohguchi H, Ohno J, Okabe M, Okada M, Okada Y, Omi N, Onodera H, Onodera K, Ooki S, Oonishi K, Oonuma H, Ooshima H, Oouchi H, Orsucci M, Paoli M, Penaud M, Perdrisot C, Petit M, Piskowski A, Plocharski A, Polis A, Polti L, Potsepnia T, Przybylski D, Pytel M, Quillet W, Remy A, Robert C, Sadowski M, Saito M, Sakuma D, Sano K, Sasaki Y, Sato N, Schneider T, Schneider C, Schwartzman K, Selivanov E, Sezaki M, Shiroishi K, Shustava I, Sniecinska A, Stalchenko E, Staron A, Stromboni M, Studzinska W, Sugisaki H, Sukegawa T, Sumida M, Suzuki Y, Suzuki K, Suzuki R, Suzuki H, Suzuki K, Swiderski W, Szudejko M, Szymaszek M, Tada J, Taguchi H, Takahashi K, Tanaka D, Tanaka G, Tanaka S, Tanino K, Tazbir K, Tcesnokova N, Tgawa N, Toda N, Tsuchiya H, Tsukamoto H, Tsushima T, Tsutsumi K, Umemura H, Uno M, Usui A, Utsumi H, Vaucelle M, Wada Y, Watanabe K, Watanabe S, Watase K, Witkowski M, Yamaki T, Yamamoto J, Yamamoto T, Yamashita M, Yanai M, Yasuda K, Yoshida Y, Yoshida A, Yoshimura K, Zmijewska M, Zuclarelli E. PMID: 26613195.
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    51. Notch, metabolism and macrophages. Oncotarget. 2015 Aug 21; 6(24):19942-3. Xu J, Chi F, Tsukamoto H. PMID: 26343518; PMCID: PMC4652967.
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    52. Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 2015 Aug; 44(6):882-7. Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M. PMID: 26166469; PMCID: PMC4503385.
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    53. Morphogen-related therapeutic targets for liver fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. Fung E, Tsukamoto H. PMID: 26206577; PMCID: PMC4687970.
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    54. ALPD 2015, Preface. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. Strauss E, Parise ER, Tsukamoto H. PMID: 26206575.
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    55. Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. Xu J, Chi F, Tsukamoto H. PMID: 26189984; PMCID: PMC4656026.
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    56. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. PMID: 26198936; PMCID: PMC4512299.
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    57. Reply: To PMID 25132354. Hepatology. 2015 Jul; 62(1):324. Lazaro R, Wu R, Tsukamoto H. PMID: 25302605.
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    58. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest. 2015 Apr; 125(4):1579-90. Xu J, Chi F, Guo T, Punj V, Lee WN, French SW, Tsukamoto H. PMID: 25798621; PMCID: PMC4396469.
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    59. Metabolic reprogramming and cell fate regulation in alcoholic liver disease. Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. Tsukamoto H. PMID: 25800177; PMCID: PMC4515387.
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    60. TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Adv Exp Med Biol. 2015; 815:131-44. Machida K, Feldman DE, Tsukamoto H. PMID: 25427905; PMCID: PMC10578031.
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    61. Low intracellular iron increases the stability of matriptase-2. J Biol Chem. 2015 Feb 13; 290(7):4432-46. Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. PMID: 25550162; PMCID: PMC4326848.
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    62. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology. 2015 Jan; 61(1):129-40. Lazaro R, Wu R, Lee S, Zhu NL, Chen CL, French SW, Xu J, Machida K, Tsukamoto H. PMID: 25132354; PMCID: PMC4280361.
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    63. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97. Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. PMID: 25457206; PMCID: PMC4629846.
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    64. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan; 148(1):203-214.e16. Chen P, Torralba M, Tan J, Embree M, Zengler K, Stärkel P, van Pijkeren JP, DePew J, Loomba R, Ho SB, Bajaj JS, Mutlu EA, Keshavarzian A, Tsukamoto H, Nelson KE, Fouts DE, Schnabl B. PMID: 25239591; PMCID: PMC4274236.
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    65. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. PMID: 26594598; PMCID: PMC4648354.
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    66. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014 Jul; 8(3):330-8. Chen CL, Tsukamoto H, Machida K. PMID: 26202636; PMCID: PMC10560513.
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    67. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. PMID: 24730561; PMCID: PMC4047166.
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    68. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014 Mar; 59(3):1118-29. Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. PMID: 24122827; PMCID: PMC3943742.
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    69. Alcohol, TLR4-TGF-β antagonism, and liver cancer. Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. Tsukamoto H, Mishra L, Machida K. PMID: 26201318; PMCID: PMC4900455.
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    71. Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells. J Gastroenterol. 2014 May; 49(5):890-9. Kagawa T, Orii R, Hirose S, Arase Y, Shiraishi K, Mizutani A, Tsukamoto H, Mine T. PMID: 23722250.
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    72. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013 Jul; 58(1):108-19. Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. PMID: 23408358; PMCID: PMC3695050.
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    73. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One. 2013; 8(4):e60534. Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. PMID: 23565256; PMCID: PMC3615098.
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    74. Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3. Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H. PMID: 23499284.
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    75. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. PMID: 23086958; PMCID: PMC3516762.
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    76. Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology. 2012 Sep; 56(3):1129-39. Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. PMID: 22488473; PMCID: PMC3430805.
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    77. Phenotypes of CCAAT/enhancer-binding protein beta deficiency: hyperdontia and elongated coronoid process. Oral Dis. 2013 Mar; 19(2):144-50. Huang B, Takahashi K, Sakata-Goto T, Kiso H, Togo Y, Saito K, Tsukamoto H, Sugai M, Akira S, Shimizu A, Bessho K. PMID: 22849712.
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    78. Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 2012 Sep; 181(3):804-17. Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G. PMID: 22841474; PMCID: PMC3432440.
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    79. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84. Zhong S, Xu J, Li P, Tsukamoto H. PMID: 22829592; PMCID: PMC3442538.
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    80. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. PMID: 22687340; PMCID: PMC3445734.
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    81. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. PMID: 22566629; PMCID: PMC3386114.
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    82. Mouse intragastric infusion (iG) model. Nat Protoc. 2012 Mar 29; 7(4):771-81. Ueno A, Lazaro R, Wang PY, Higashiyama R, Machida K, Tsukamoto H. PMID: 22461066; PMCID: PMC4197794.
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    83. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. PMID: 22320911; PMCID: PMC3306127.
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    84. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. PMID: 22320925; PMCID: PMC3337168.
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    85. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. PMID: 22095555; PMCID: PMC3302956.
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    86. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-10367. Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. PMID: 22298767; PMCID: PMC3322997.
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    87. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. PMID: 22207628; PMCID: PMC3271911.
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    88. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb; 61(2):172-8. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. PMID: 22115911; PMCID: PMC3245897.
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    89. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207; PMCID: PMC4388239.
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    90. Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82. Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. PMID: 21504520; PMCID: PMC4321904.
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    91. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. PMID: 21463341; PMCID: PMC3131439.
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    92. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. Asahina K, Zhou B, Pu WT, Tsukamoto H. PMID: 21294146; PMCID: PMC3078645.
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    93. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682. Xu J, Lai KKY, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. PMID: 21256905; PMCID: PMC3094601.
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    94. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. PMID: 21254165; PMCID: PMC3059122.
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    95. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. PMID: 21134374; PMCID: PMC3049833.
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    96. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood. 2011 Feb 03; 117(5):1687-99. Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. PMID: 21115976; PMCID: PMC3056593.
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    97. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. Zhong S, Machida K, Tsukamoto H, Johnson DL. PMID: 21106530; PMCID: PMC3024733.
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    98. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. PMID: 20683948; PMCID: PMC3107125.
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    99. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. J Biol Chem. 2010 Oct 01; 285(40):30463-71. Zhu NL, Wang J, Tsukamoto H. PMID: 20663865; PMCID: PMC2945539.
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    100. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. PMID: 20427470; PMCID: PMC2904160.
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    101. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar; 51(3):932-41. Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. PMID: 19957376; PMCID: PMC2898175.
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    102. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Hepatology. 2010 Mar; 51(3):986-95. Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC. PMID: 20043323; PMCID: PMC2905860.
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    103. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol. 2010 Mar; 52(3):407-16. Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. PMID: 20129692.
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    104. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010 Feb; 138(2):705-14, 714.e1-4. Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA. PMID: 19843474; PMCID: PMC2819585.
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    105. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. PMID: 19828633; PMCID: PMC3633447.
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    106. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. Yeligar S, Tsukamoto H, Kalra VK. PMID: 19783678; PMCID: PMC3622549.
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    107. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. PMID: 19444874; PMCID: PMC2754739.
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    108. Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem. 2009 Aug 21; 284(34):22580-9. Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA. PMID: 19564337; PMCID: PMC2755665.
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    109. "Second hit" models of alcoholic liver disease. Semin Liver Dis. 2009 May; 29(2):178-87. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. PMID: 19387917; PMCID: PMC4197797.
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    110. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009 Mar; 9(3):217-27. Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. PMID: 19254567; PMCID: PMC2673483.
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    111. Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas. 2009 Mar; 38(2):e47-52. Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. PMID: 19248221; PMCID: PMC4662660.
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    112. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. PMID: 19085956; PMCID: PMC2673117.
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    113. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. PMID: 19171902; PMCID: PMC2635765.
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    114. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology. 2009 May; 136(5):1783-95.e10. Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, Kojima S. PMID: 19208340; PMCID: PMC4960455.
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    115. C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. Oncogene. 2008 Dec 04; 27(53):6749-60. Matsushita H, Nakajima H, Nakamura Y, Tsukamoto H, Tanaka Y, Jin G, Yabe M, Asai S, Ono R, Nosaka T, Sugita K, Morimoto A, Hayashi Y, Hotta T, Ando K, Miyachi H. PMID: 18776924.
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    116. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. PMID: 18782341; PMCID: PMC3369540.
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    117. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. Mello T, Nakatsuka A, Fears S, Davis W, Tsukamoto H, Bosron WF, Sanghani SP. PMID: 18639528; PMCID: PMC2566784.
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    118. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. Xiong S, She H, Zhang AS, Wang J, Mkrtchyan H, Dynnyk A, Gordeuk VR, French SW, Enns CA, Tsukamoto H. PMID: 18599584; PMCID: PMC2536779.
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    119. Fat paradox of steatohepatitis. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. Tsukamoto H, She H, Hazra S, Cheng J, Wang J. PMID: 18336651.
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    120. Intragastric ethanol infusion model in rodents. Methods Mol Biol. 2008; 447:33-48. Tsukamoto H, Mkrtchyan H, Dynnyk A. PMID: 18369909.
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    121. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. PMID: 18006602.
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    122. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. PMID: 17668871; PMCID: PMC3494299.
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    123. A rat model reproducing key pathological responses of alcoholic chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Hong PP, Jung YJ, Deng QG, French BA, Lungo W, French SW, Tsukamoto H, Pandol SJ. PMID: 17884979.
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    124. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. J Gastroenterol. 2007 Aug; 42(8):603-9. Tsukamoto H. PMID: 17701122.
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    125. A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem. 2007 Apr 27; 282(17):12928-39. Han YP, Yan C, Zhou L, Qin L, Tsukamoto H. PMID: 17322299; PMCID: PMC2376818.
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    126. Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. J Biol Chem. 2007 Feb 23; 282(8):5582-8. Chen L, Xiong S, She H, Lin SW, Wang J, Tsukamoto H. PMID: 17172471.
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    127. Epigenetic mechanism of stellate cell trans-differentiation. J Hepatol. 2007 Feb; 46(2):352-3. Tsukamoto H. PMID: 17161490.
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    128. Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. Pandol SJ, Tsukamoto H. PMID: 16958661.
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    129. Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. Tsukamoto H, She H, Hazra S, Cheng J, Miyahara T. PMID: 16958658.
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    130. Fat paradox in liver disease. Keio J Med. 2005 Dec; 54(4):190-2. Tsukamoto H. PMID: 16452829.
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    131. Adipogenic phenotype of hepatic stellate cells. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. Tsukamoto H. PMID: 16344597.
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    132. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem. 2005 Dec 09; 280(49):40650-9. Yavrom S, Chen L, Xiong S, Wang J, Rippe RA, Tsukamoto H. PMID: 16216869.
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    133. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology. 2005 Oct; 42(4):905-14. Deng QG, She H, Cheng JH, French SW, Koop DR, Xiong S, Tsukamoto H. PMID: 16175602.
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    134. A phase I-II trial of autologous peripheral blood stem cell transplantation in the treatment of refractory autoimmune disease. Ann Rheum Dis. 2006 Apr; 65(4):508-14. Tsukamoto H, Nagafuji K, Horiuchi T, Miyamoto T, Aoki K, Takase K, Henzan H, Himeji D, Koyama T, Miyake K, Inoue Y, Nakashima H, Otsuka T, Tanaka Y, Nagasawa K, Harada M. PMID: 16126798; PMCID: PMC1798095.
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    135. Hepatoprotective mechanisms of Yan-gan-wan. Hepatol Res. 2005 Aug; 32(4):202-12. Yang MD, Deng QG, Chen S, Xiong S, Koop D, Tsukamoto H. PMID: 16107322.
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    136. A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease. Addict Behav. 2005 Mar; 30(3):465-73. Sussman S, Runyon BA, Hernandez R, Magallanes M, Mendler M, Yuan JM, Tsukamoto H. PMID: 15718064.
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    137. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005 Feb 11; 280(6):4959-67. She H, Xiong S, Hazra S, Tsukamoto H. PMID: 15537655.
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    138. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. PMID: 15131799.
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    139. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. PMID: 15064230.
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    140. Signaling role of iron in NF-kappa B activation in hepatic macrophages. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. Xiong S, She H, Tsukamoto H. PMID: 14960188; PMCID: PMC2410254.
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    141. PPAR Gamma and Hepatic Stellate Cells. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. Hazra S, Miyahara T, Rippe RA, Tsukamoto H. PMID: 14960159; PMCID: PMC2410230.
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    142. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem. 2004 Mar 19; 279(12):11392-401. Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, Chatterjee K, Tsukamoto H. PMID: 14702344.
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    143. Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. Sung CK, She H, Xiong S, Tsukamoto H. PMID: 14656714.
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    144. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem. 2004 Feb 06; 279(6):4820-8. Han YP, Zhou L, Wang J, Xiong S, Garner WL, French SW, Tsukamoto H. PMID: 14617627; PMCID: PMC2430939.
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    145. Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county. Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. Tao N, Sussman S, Nieto J, Tsukamoto H, Yuan JM. PMID: 14634496.
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    146. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 2004 Feb 15; 103(4):1509-14. Zhang AS, Xiong S, Tsukamoto H, Enns CA. PMID: 14563638.
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    147. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol. 2003 Jun; 30(2):107-13. Xiong S, She H, Sung CK, Tsukamoto H. PMID: 12957294.
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    148. A novel polymorphism of the human APRIL gene is associated with systemic lupus erythematosus. Rheumatology (Oxford). 2003 Aug; 42(8):980-5. Koyama T, Tsukamoto H, Masumoto K, Himeji D, Hayashi K, Harada M, Horiuchi T. PMID: 12730512.
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    149. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. PMID: 12637578.
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    150. Aberrant HS1 molecule in a patient with systemic lupus erythematosus. Genes Immun. 2003 Mar; 4(2):122-31. Sawabe T, Horiuchi T, Koga R, Tsukamoto H, Kojima T, Harashima S, Kikuchi Y, Otsuka J, Mitoma H, Yoshizawa S, Niho Y, Watanabe T. PMID: 12618860.
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    151. Redox regulation of cytokine expression in Kupffer cells. Antioxid Redox Signal. 2002 Oct; 4(5):741-8. Tsukamoto H. PMID: 12470501.
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    152. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. PMID: 12181188.
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    153. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol. 2002 Jul; 27(3):155-62. Lu SC, Tsukamoto H, Mato JM. PMID: 12163143.
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    154. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. Mathurin P, Xiong S, Kharbanda KK, Veal N, Miyahara T, Motomura K, Rippe RA, Bachem MG, Tsukamoto H. PMID: 12016123.
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    155. Alcoholic liver disease (ALD): a new domain for prevention efforts. Subst Use Misuse. 2002; 37(14):1887-904. Sussman S, Dent CW, Skara S, de Calice P, Tsukamoto H. PMID: 12511057.
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    156. Association of tumor necrosis factor receptor type II polymorphism 196R with Systemic lupus erythematosus in the Japanese: molecular and functional analysis. Arthritis Rheum. 2001 Dec; 44(12):2819-27. Morita C, Horiuchi T, Tsukamoto H, Hatta N, Kikuchi Y, Arinobu Y, Otsuka T, Sawabe T, Harashima S, Nagasawa K, Niho Y. PMID: 11762942.
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    157. Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications. Prostaglandins Leukot Essent Fatty Acids. 2001 Oct; 65(4):191-6. Hishinuma T, Tsukamoto H, Suzuki K, Mizugaki M. PMID: 11728171.
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    158. Wnt signaling regulates hemopoiesis through stromal cells. J Immunol. 2001 Jul 15; 167(2):765-72. Yamane T, Kunisada T, Tsukamoto H, Yamazaki H, Niwa H, Takada S, Hayashi SI. PMID: 11441081.
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    159. Defect of lck in a patient with common variable immunodeficiency. Int J Mol Med. 2001 Jun; 7(6):609-14. Sawabe T, Horiuchi T, Nakamura M, Tsukamoto H, Nakahara K, Harashima SI, Tsuchiya T, Nakano S. PMID: 11351273.
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    160. Gadolinium chloride-induced hepatocyte proliferation is prevented by antibodies to tumor necrosis factor alpha. Toxicol Appl Pharmacol. 2001 Jan 01; 170(1):39-45. Rose ML, Bradford BU, Germolec DR, Lin M, Tsukamoto H, Thurman RG. PMID: 11141354.
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    161. Outside-to-inside signal through the membrane TNF-alpha induces E-selectin (CD62E) expression on activated human CD4+ T cells. J Immunol. 2001 Jan 01; 166(1):130-6. Harashima S, Horiuchi T, Hatta N, Morita C, Higuchi M, Sawabe T, Tsukamoto H, Tahira T, Hayashi K, Fujita S, Niho Y. PMID: 11123285.
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    162. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. Am J Physiol Gastrointest Liver Physiol. 2000 Dec; 279(6):G1333-42. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Solís-Herruzo JA, Tsukamoto H, Brenner DA, Rippe RA. PMID: 11093957.
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    163. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem. 2000 Nov 17; 275(46):35715-22. Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF, Motomura K, Anania FA, Willson TM, Tsukamoto H. PMID: 10969082.
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    164. Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology. 2000 Nov; 32(5):1008-17. Mathurin P, Deng QG, Keshavarzian A, Choudhary S, Holmes EW, Tsukamoto H. PMID: 11050051.
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    165. Changes in methionine adenosyltransferase and S-adenosylmethionine homeostasis in alcoholic rat liver. Am J Physiol Gastrointest Liver Physiol. 2000 Jul; 279(1):G178-85. Lu SC, Huang ZZ, Yang H, Mato JM, Avila MA, Tsukamoto H. PMID: 10898761.
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    166. Cyp2e1 and ALD. Hepatology. 2000 Jul; 32(1):154-6. Tsukamoto H. PMID: 10869305.
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    167. Dominant expression of a novel splice variant of caspase-8 in human peripheral blood lymphocytes. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):877-81. Horiuchi T, Himeji D, Tsukamoto H, Harashima S, Hashimura C, Hayashi K. PMID: 10860845.
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    168. Meningitis carcinomatosa originating from an alpha fetoprotein-producing gastric cancer. Intern Med. 2000 Mar; 39(3):223-7. Tsujikawa T, Tsukamoto H, Itoh A, Andoh A, Sasaki M, Koyama S, Fujiyama Y, Bamba T. PMID: 10772124.
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    169. RAR and RXR expression by Kupffer cells. Exp Mol Pathol. 2000 Feb; 68(1):13-20. Ohata M, Yamauchi M, Takeda K, Toda G, Kamimura S, Motomura K, Xiong S, Tsukamoto H. PMID: 10640450.
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    170. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am J Physiol. 1999 12; 277(6):G1240-50. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. PMID: 10600822.
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    171. Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the Rat. Toxicol Appl Pharmacol. 1999 Sep 15; 159(3):161-8. Lu SC, Huang ZZ, Yang H, Tsukamoto H. PMID: 10486302.
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    172. Ethanol diet increases the sensitivity of rats to pancreatitis induced by cholecystokinin octapeptide. Gastroenterology. 1999 Sep; 117(3):706-16. Pandol SJ, Periskic S, Gukovsky I, Zaninovic V, Jung Y, Zong Y, Solomon TE, Gukovskaya AS, Tsukamoto H. PMID: 10464148.
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    173. Effect of ethanol and high-fat feeding on hepatic gamma-glutamylcysteine synthetase subunit expression in the rat. Hepatology. 1999 Jul; 30(1):209-14. Lu SC, Huang ZZ, Yang JM, Tsukamoto H. PMID: 10385658.
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    174. Cytokine regulation of hepatic stellate cells in liver fibrosis. Alcohol Clin Exp Res. 1999 May; 23(5):911-6. Tsukamoto H. PMID: 10371413.
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    175. Relationship between serum levels of anti-low-density lipoprotein-acetaldehyde-adduct antibody and aldehyde dehydrogenase 2 heterozygotes in patients with alcoholic liver injury. Alcohol Clin Exp Res. 1999 Apr; 23(4 Suppl):24S-28S. Nagata N, Watanabe N, Tsuda M, Tsukamoto H, Matsuzaki S. PMID: 10235274.
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    176. Is interleukin-10 antifibrogenic in chronic liver injury? Hepatology. 1998 Dec; 28(6):1707-9. Tsukamoto H. PMID: 9828239.
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    177. Drug delivery of antisense molecules to the brain for treatment of Alzheimer's disease and cerebral AIDS. J Pharm Sci. 1998 Nov; 87(11):1308-15. Boado RJ, Tsukamoto H, Pardridge WM. PMID: 9811482.
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    178. Identification of the 150-kDa surface antigen of Entamoeba histolytica as a galactose- and N-acetyl-D-galactosamine-inhibitable lectin. Parasitol Res. 1998 Aug; 84(8):632-9. Cheng XJ, Tsukamoto H, Kaneda Y, Tachibana H. PMID: 9747935.
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    179. Molecular mechanism of induced hepatic macrophage cytokine gene expression in experimental alcoholic liver injury. Alcohol Clin Exp Res. 1998 Aug; 22(5 Suppl):253S-254S. Tsukamoto H. PMID: 9727646.
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    180. GLUT1 glucose transporter: differential gene transcription and mRNA binding to cytosolic and polysome proteins in brain and peripheral tissues. Brain Res Mol Brain Res. 1998 Jul 15; 58(1-2):170-7. Tsukamoto H, Hamada Y, Wu D, Boado RJ, Pardridge WM. PMID: 9685631.
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    181. WY-14 643 rapidly activates nuclear factor kappaB in Kupffer cells before hepatocytes. Carcinogenesis. 1998 Jul; 19(7):1217-22. Rusyn I, Tsukamoto H, Thurman RG. PMID: 9683180.
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    182. Polymorphism in the Ialpha1 germ-line transcript regulatory region and IgA productivity in patients with IgA nephropathy. J Immunol. 1998 May 15; 160(10):4936-42. Yano N, Asakura K, Endoh M, Abe Y, Nomoto Y, Sakai H, Kurokawa K, Tsukamoto H. PMID: 9590241.
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    183. The carboxyl-terminal region of protein C is essential for its secretion. Blood. 1998 May 15; 91(10):3784-91. Katsumi A, Kojima T, Senda T, Yamazaki T, Tsukamoto H, Sugiura I, Kobayashi S, Miyata T, Umeyama H, Saito H. PMID: 9573015.
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    184. Molecular mechanisms of type II factor XIII deficiency: novel Gly562-Arg mutation and C-terminal truncation of the A subunit cause factor XIII deficiency as characterized in a mammalian expression system. Blood. 1998 Apr 15; 91(8):2830-8. Takahashi N, Tsukamoto H, Umeyama H, Castaman G, Rodeghiero F, Ichinose A. PMID: 9531593.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    185. Results of resection of gastric cancer with distant metastases. Hepatogastroenterology. 1998 Mar-Apr; 45(20):592-6. Kikuchi S, Tsukamoto H, Mieno H, Sato K, Kobayashi N, Shimao H, Sakakibara Y, Hiki Y, Kakita A. PMID: 9638458.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    186. Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem. 1998 Jan 02; 273(1):302-8. Wang SC, Ohata M, Schrum L, Rippe RA, Tsukamoto H. PMID: 9417080.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    187. Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages. Am J Physiol. 1997 Jun; 272(6 Pt 1):G1355-64. Lin M, Rippe RA, Niemelä O, Brittenham G, Tsukamoto H. PMID: 9227470.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    188. Site-directed deletion of a 10-nucleotide domain of the 3'-untranslated region of the GLUT1 glucose transporter mRNA eliminates cytosolic protein binding in human brain tumors and induction of reporter gene expression. J Neurochem. 1997 Jun; 68(6):2587-92. Tsukamoto H, Boado RJ, Pardridge WM. PMID: 9166756.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    189. Iron overload in the rat pancreas following portacaval shunting and dietary iron supplementation. Exp Mol Pathol. 1997 Apr; 64(2):90-102. Horne WI, Tandler B, Dubick MA, Niemelä O, Brittenham GM, Tsukamoto H. PMID: 9316587.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    190. Diminished retinoic acid signaling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol. 1997 Mar; 272(3 Pt 1):G589-96. Ohata M, Lin M, Satre M, Tsukamoto H. PMID: 9124579.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    191. A new type of major aminopeptidase in bovine brain. Biochem Mol Med. 1996 Dec; 59(2):161-8. Yanagisawa J, Tsuda M, Ohkubo T, Hiyoshi M, Kamiguchi H, Tsukamoto H, Yamamura M, Kocha T, Aoyagi T. PMID: 8986639.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    192. Evidence for translational control elements within the 5'-untranslated region of GLUT1 glucose transporter mRNA. J Neurochem. 1996 Oct; 67(4):1335-43. Boado RJ, Tsukamoto H, Pardridge WM. PMID: 8858913.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    193. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology. 1996 Sep; 24(3):670-6. Wang SC, Tsukamoto H, Brenner DA, Rippe RA. PMID: 8781341.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    194. Down-regulation of secretion of human complement component C2 by the product of an alternatively spliced C2 messenger RNA. J Immunol. 1996 Jun 15; 156(12):4901-8. Tsukamoto H, Tousson A, Marchase RB, Volanakis JE. PMID: 8648140.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    195. Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. J Clin Invest. 1996 Jun 15; 97(12):2823-32. Tsukamoto H, Boado RJ, Pardridge WM. PMID: 8675694; PMCID: PMC507376.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    196. Giant mitochondria induced in rat pancreatic exocrine cells by ethanol and iron. Anat Rec. 1996 May; 245(1):65-75. Tandler B, Horne WI, Brittenham GM, Tsukamoto H. PMID: 8731042.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    197. Effect of MCI-186 on postischemic reperfusion injury in isolated rat heart. Free Radic Res. 1996 May; 24(5):361-7. Minhaz U, Tanaka M, Tsukamoto H, Watanabe K, Koide S, Shohtsu A, Nakazawa H. PMID: 8733940.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    198. Effects of dietary polyunsaturated fat on ethanol-induced Ito cell activation. Am J Physiol. 1996 Apr; 270(4 Pt 1):G581-6. Tsukamoto H, Cheng S, Blaner WS. PMID: 8928787.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    199. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease. J Neurochem. 1996 Mar; 66(3):1118-24. Sakai N, Inui K, Tatsumi N, Fukushima H, Nishigaki T, Taniike M, Nishimoto J, Tsukamoto H, Yanagihara I, Ozono K, Okada S. PMID: 8769874.
      View in: PubMed   Mentions: 77     Fields:    Translation:HumansAnimalsCells
    200. Glutathione peroxidase activity in endometrium: effects of sex hormones and cancer. Gynecol Oncol. 1996 Feb; 60(2):277-82. Ohwada M, Suzuki M, Sato I, Tsukamoto H, Watanabe K. PMID: 8631551.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    201. Oxidative stress and liver disease. Prog Liver Dis. 1996; 14:131-59. Kaplowitz N, Tsukamoto H. PMID: 9055577.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    202. Molecular defects in Krabbe disease. Hum Mol Genet. 1995 Oct; 4(10):1865-8. Tatsumi N, Inui K, Sakai N, Fukushima H, Nishimoto J, Yanagihara I, Nishigaki T, Tsukamoto H, Fu L, Taniike M, et al. PMID: 8595408.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    203. Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology. 1995 Oct; 22(4 Pt 1):1304-9. Kamimura S, Tsukamoto H. PMID: 7557885.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    204. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest. 1995 Jul; 96(1):620-30. Tsukamoto H, Horne W, Kamimura S, Niemelä O, Parkkila S, Ylä-Herttuala S, Brittenham GM. PMID: 7615836; PMCID: PMC185237.
      View in: PubMed   Mentions: 119     Fields:    Translation:AnimalsCells
    205. Non-iron mediated alteration in hepatic transferrin gene expression in the nephrotic rat. Kidney Int. 1995 Apr; 47(4):1068-77. Kaysen GA, Sun X, Jones H, Martin VI, Joles JA, Tsukamoto H, Couser WG, al-Bander H. PMID: 7783403.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    206. Bispecific antibody-mediated cytotoxicity by CD4+ and CD8(+)-activated T cells generated from leukemia patients after allogeneic bone marrow transplantation. Bone Marrow Transplant. 1995 Feb; 15(2):193-8. Hattori K, Tsukamoto H, Ohta S, Yabe M, Yabe H, Kato S, Takakura I, Ueda R, Habu S, Nishimura T. PMID: 7773208.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    207. Roles of oxidative stress in activation of Kupffer and Ito cells in liver fibrogenesis. J Gastroenterol Hepatol. 1995; 10 Suppl 1:S50-3. Tsukamoto H, Rippe R, Niemelä O, Lin M. PMID: 8589343.
      View in: PubMed   Mentions: 24     Fields:    Translation:AnimalsCells
    208. Tumor-associated glycoantigen, sialyl Lewis(a) as a target for bispecific antibody-directed adoptive tumor immunotherapy. Immunol Lett. 1995 Jan; 44(1):35-40. Ohta S, Tsukamoto H, Watanabe K, Makino K, Kuge S, Hanai N, Habu S, Nishimura T. PMID: 7721341.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    209. Fatty Liver, Hepatitus, and Cirrhosis in Sub-Human Primates Fed Ethanol. Alcohol Health Res World. 1995; 19(1):42-43. Tsukamoto H. PMID: 31798089; PMCID: PMC6875784.
      View in: PubMed   Mentions:    Fields:    
    210. [A case of nodular regenerative hyperplasia (NRH) of the liver associated with recurrent hepatic encephalopathy due to splenorenal shunt]. Nihon Shokakibyo Gakkai Zasshi. 1994 Jun; 91(6):1136-40. Moriyama A, Shimamura R, Igarashi H, Tsukamoto H, Takii M, Okubo H, Toyoshima S. PMID: 8028207.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    211. Dietary modulation of alcohol-induced pancreatic injury. Alcohol. 1993 Nov-Dec; 10(6):481-4. Horne WI, Tsukamoto H. PMID: 8123204.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    212. Evolution of intragastric ethanol infusion model. Alcohol. 1993 Nov-Dec; 10(6):437-41. Tsukamoto H, French SW. PMID: 8123196.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    213. Mitochondrial glutathione depletion in alcoholic liver disease. Alcohol. 1993 Nov-Dec; 10(6):469-75. Fernández-Checa JC, Hirano T, Tsukamoto H, Kaplowitz N. PMID: 8123202.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    214. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis. Alcohol. 1993 Nov-Dec; 10(6):465-7. Tsukamoto H. PMID: 8123201.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    215. Specific targeting of in vitro-activated human antitumour effector cells using anti-CD3 x anti-c-erbB-2 bispecific antibody. Immunol Cell Biol. 1993 Apr; 71 ( Pt 2):109-15. Tsukamoto H, Nakamura Y, Masuko T, Hashimoto Y, Habu S, Nishimura T. PMID: 8098011.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    216. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology. 1992 Dec; 16(6):1423-7. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. PMID: 1446896.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    217. Role of cytochrome P-450 2E1 in ethanol-, carbon tetrachloride- and iron-dependent microsomal lipid peroxidation. Hepatology. 1992 Oct; 16(4):992-6. Castillo T, Koop DR, Kamimura S, Triadafilopoulos G, Tsukamoto H. PMID: 1398507.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    218. Mucosal immune dysfunction associated with alcoholic IgA nephropathy. Clin Immunol Immunopathol. 1992 Sep; 64(3):205-9. Smith SM, Tokuda S, Tsukamoto H. PMID: 1643753.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    219. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology. 1992 Aug; 16(2):448-53. Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. PMID: 1639354.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    220. Mitochondrial tRNA(Ile) mutation in fatal cardiomyopathy. Biochem Biophys Res Commun. 1992 Jul 15; 186(1):47-53. Taniike M, Fukushima H, Yanagihara I, Tsukamoto H, Tanaka J, Fujimura H, Nagai T, Sano T, Yamaoka K, Inui K, et al. PMID: 1632786.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    221. Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumour immunotherapy. Br J Cancer. 1992 Jul; 66(1):20-6. Nakamura Y, Tokuda Y, Iwasawa M, Tsukamoto H, Kidokoro M, Kobayashi N, Kato S, Mitomi T, Habu S, Nishimura T. PMID: 1353365; PMCID: PMC1977880.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    222. Time dependency of IgA nephropathy induction in alcohol ingestion. Alcohol Clin Exp Res. 1992 Jun; 16(3):471-3. Smith SM, Tsukamoto H. PMID: 1626647.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    223. Human c-erbB-2 proto-oncogene product as a target for bispecific-antibody-directed adoptive tumor immunotherapy. Int J Cancer. 1992 Mar 12; 50(5):800-4. Nishimura T, Nakamura Y, Tsukamoto H, Takeuchi Y, Tokuda Y, Iwasawa M, Yamamoto T, Masuko T, Hashimoto Y, Habu S. PMID: 1347516.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    224. Localization of sex steroid receptor cells, with special reference to thymulin (FTS)-producing cells in female rat thymus. Thymus. 1991 Sep; 18(2):79-93. Kawashima I, Sakabe K, Seiki K, Fujii-Hanamoto H, Akatsuka A, Tsukamoto H. PMID: 1926294.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    225. Glutathione peroxidase and glutathione S-transferase, class alpha, in rat intestine. Immunohistochemical and immunoblotting studies on changes in expression of these antilipoperoxidative enzymes during normal development. Acta Pathol Jpn. 1991 Aug; 41(8):573-80. Tauchi K, Tsutsumi Y, Tsukamoto H, Hasegawa H, Yoshimura S, Watanabe K. PMID: 1750355.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    226. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology. 1990 Sep; 12(3 Pt 1):599-608. Tsukamoto H, Gaal K, French SW. PMID: 2205558.
      View in: PubMed   Mentions: 32     Fields:    Translation:AnimalsCells
    227. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 1990 Apr; 11(4):599-605. Matsuoka M, Tsukamoto H. PMID: 2328954.
      View in: PubMed   Mentions: 75     Fields:    Translation:AnimalsCells
    228. IgA nephropathy in alcohol abuse. An animal model. Lab Invest. 1990 Feb; 62(2):179-84. Smith SM, Yu GS, Tsukamoto H. PMID: 2304330.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    229. Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis. Hepatology. 1990 Feb; 11(2):173-82. Matsuoka M, Zhang MY, Tsukamoto H. PMID: 2307396.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    230. Experimental models of hepatic fibrosis: a review. Semin Liver Dis. 1990 Feb; 10(1):56-65. Tsukamoto H, Matsuoka M, French SW. PMID: 2110685.
      View in: PubMed   Mentions: 73     Fields:    Translation:Animals
    231. Influence of differences in tumor vascularity upon the effects of hyperthermia. Urol Res. 1990; 18(5):313-8. Onishi T, Machida T, Iizuka N, Nakauchi K, Shirakawa H, Masuda F, Mochizuki S, Tsukamoto H, Harada N. PMID: 2256231.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    232. Animal models for alcoholic liver disease. Hepatology. 1989 Nov; 10(5):898-9. French SW, Tsukamoto H. PMID: 2807174.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    233. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease. Exp Mol Pathol. 1989 Oct; 51(2):141-8. Nanji AA, Tsukamoto H, French SW. PMID: 2806468.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    234. Differential effects of interleukin-1 alpha, tumor necrosis factor alpha, and transforming growth factor beta 1 on cell proliferation and collagen formation by cultured fat-storing cells. Liver. 1989 Apr; 9(2):71-8. Matsuoka M, Pham NT, Tsukamoto H. PMID: 2785237.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    235. Hyperthermia with simultaneous administration of interferon using established human renal carcinoma heterotransplanted in nude mice. Br J Urol. 1989 Mar; 63(3):227-32. Onishi T, Machida T, Mori Y, Iizuka N, Masuda F, Mochizuki S, Tsukamoto H, Harada N. PMID: 2495145.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    236. Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis. Hepatology. 1989 Feb; 9(2):302-6. Tsukamoto H, Xi XP. PMID: 2912830.
      View in: PubMed   Mentions: 17     Fields:    Translation:Animals
    237. [Abnormal cholecystokinin-acinar function coupling in atrophied pancreatic acini from rats fed ethanol and a high-fat diet]. Arukoru Kenkyuto Yakubutsu Ison. 1988 Dec; 23(4):332-50. Tsukamoto H, Otsuki M, Baba S, Mizoi Y. PMID: 2472128.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    238. Potentiation of ethanol-induced pancreatic injury by dietary fat. Induction of chronic pancreatitis by alcohol in rats. Am J Pathol. 1988 May; 131(2):246-57. Tsukamoto H, Towner SJ, Yu GS, French SW. PMID: 3358454; PMCID: PMC1880607.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    239. Lack of evidence for increased lipid peroxidation in ethanol-induced centrilobular necrosis of rat liver. Liver. 1987 Aug; 7(4):233-9. Inomata T, Rao GA, Tsukamoto H. PMID: 3683096.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    240. Increased pancreatic acinar content and secretion of cationic trypsinogen following 30-day continuous ethanol intoxication in rats. Biochem Pharmacol. 1986 Oct 15; 35(20):3623-9. Tsukamoto H, Sankaran H, Delgado G, Reidelberger RD, Deveney CW, Largman C. PMID: 3768045.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    241. Ethanol-induced liver fibrosis in rats fed high fat diet. Hepatology. 1986 Sep-Oct; 6(5):814-22. Tsukamoto H, Towner SJ, Ciofalo LM, French SW. PMID: 3758935.
      View in: PubMed   Mentions: 50     Fields:    Translation:Animals
    242. Ethanol-induced hepatic fibrosis in the rat: role of the amount of dietary fat. Alcohol Clin Exp Res. 1986; 10(6 Suppl):13S-19S. French SW, Miyamoto K, Tsukamoto H. PMID: 3544925.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    243. Comparison of tyrosine phosphorylation of proteins by membrane fractions from mouse liver, Ehrlich ascites tumor and MH134 hepatoma. FEBS Lett. 1985 May 06; 184(1):60-4. Usui H, Yoshikawa K, Imazu M, Tsukamoto H, Takeda M. PMID: 3872813.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    244. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology. 1985 Mar-Apr; 5(2):224-32. Tsukamoto H, French SW, Benson N, Delgado G, Rao GA, Larkin EC, Largman C. PMID: 3979954.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    245. Cyclical pattern of blood alcohol levels during continuous intragastric ethanol infusion in rats. Alcohol Clin Exp Res. 1985 Jan-Feb; 9(1):31-7. Tsukamoto H, French SW, Reidelberger RD, Largman C. PMID: 3887966.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimals
    246. Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol. 1984 Sep; 247(3 Pt 2):R595-9. Tsukamoto H, Reidelberger RD, French SW, Largman C. PMID: 6433728.
      View in: PubMed   Mentions: 33     Fields:    Translation:Animals
    247. Hepatic origin of triglycerides in fatty livers produced by the continuous intragastric infusion of an ethanol diet. Lipids. 1984 Jun; 19(6):419-22. Tsukamoto H, Lew G, Larkin EC, Largman C, Rao GA. PMID: 6738318.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    248. [Studies on the direct extraction method for determination of lead in blood by atomic absorption spectrophotometry (author's transl)]. Rinsho Byori. 1978 Jul; 26(7):611-4. Matsumoto T, Kitamura T, Abe H, Tsukamoto H. PMID: 713098.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    249. Activation and isolation of mitochondrial adenosine triphosphatase by ultrasonic irradiation. Acta Med Okayama (1952). 1970 Feb; 24(1):49-64. Yamamoto G, Oda T, Tsukamoto H. PMID: 4246831.
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