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Hidekazu Tsukamoto, PhD

TitleProfessor of Pathology
InstitutionUniversity of Southern California
DepartmentPathology
AddressMMR 1333 San Pablo St
Health Sciences Campus
Los Angeles CA 90089-9141
Phone+1 323 442 5107
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    Collapse Research 
    Collapse Research Activities and Funding
    BLR&D Research Career Scientist Award Application
    VA IK6BX004205Apr 1, 2018 - Mar 31, 2025
    Role: Principal Investigator
    Molecular Mechanisms of Stellate Cell Activation in Liver Fibrosis
    VA I01BX001991Oct 1, 2013 - Sep 30, 2017
    Role: Principal Investigator
    The dynamics and mechanisms of autophagy in ethanol - induced liver pathogenesis
    NIH/NIAAA R01AA021751Aug 15, 2013 - Jul 31, 2018
    Role: Co-Principal Investigator
    International Symposium of ALPD and Cirrhosis
    NIH/NIAAA R13AA020691Aug 5, 2011 - Apr 30, 2021
    Role: Principal Investigator
    Epigenetic Regulation of Alcoholic Liver Fibrosis
    NIH/NIAAA U01AA018663Sep 1, 2010 - Aug 31, 2020
    Role: Principal Investigator
    15th International Symposium on Cells of the Hepatic Sinusoid
    NIH/NIAAA R13AA019890Jul 1, 2010 - Jun 30, 2011
    Role: Principal Investigator
    TLR4 and TGF-beta interactions in HCC induced by HCV and alcohol
    NIH/NIAAA RC2AA019392Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Epigenetic mechanism of HSC transdifferentiation in alcoholic liver fibrosis
    NIH/NIAAA R21AA016682Sep 30, 2006 - Aug 31, 2009
    Role: Principal Investigator
    Iron Signaling/Monocytes/Alcoholic Hepatitis Patients
    NIH/NIAAA R21AA015162Sep 10, 2004 - Aug 31, 2007
    Role: Principal Investigator
    Integrative Liver Cell Core
    NIH/NIAAA R24AA012885Jun 1, 2001 - May 31, 2021
    Role: Principal Investigator
    NON-PARENCHYMAL LIVER CELL CORE
    NIH/NIAAA R01AA012885Jun 1, 2001 - May 31, 2006
    Role: Principal Investigator
    Training Program in Alcoholic Liver&Pancreatic Diseases
    NIH/NIAAA T32AA007578May 1, 2000 - Apr 30, 2011
    Role: Principal Investigator
    Southern California Research Center for ALPD and Cirrhosis
    NIH/NIAAA P50AA011999Jan 1, 1999 - Dec 31, 2018
    Role: Principal Investigator
    PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH/NIAAA R37AA006603Sep 1, 1991 - Nov 30, 2004
    Role: Principal Investigator
    PATHOGENESIS OF ALCOHOL LIVER INJURY
    NIH/NIAAA R01AA006603Jun 1, 1984 - Nov 30, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 Aug 28; 4(1):18. PMID: 30154473.
      View in: PubMed
    2. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Alcoholic liver disease. Nat Rev Dis Primers. 2018 Aug 16; 4(1):16. PMID: 30115921.
      View in: PubMed
    3. Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H. Baicalein targets GTPase-mediated autophagy to eliminate liver tumor initiating stem cell-like cells resistant to mTORC1 inhibition. Hepatology. 2018 May 05. PMID: 29729190.
      View in: PubMed
    4. Khanova E, Wu R, Wang W, Yan R, Chen Y, French SW, Llorente C, Pan SQ, Yang Q, Li Y, Lazaro R, Ansong C, Smith RD, Bataller R, Morgan T, Schnabl B, Tsukamoto H. Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. Hepatology. 2018 May; 67(5):1737-1753. PMID: 29108122.
      View in: PubMed
    5. Baulies A, Montero J, Matías N, Insausti N, Terrones O, Basañez G, Vallejo C, Conde de La Rosa L, Martinez L, Robles D, Morales A, Abian J, Carrascal M, Machida K, Kumar DBU, Tsukamoto H, Kaplowitz N, Garcia-Ruiz C, Fernández-Checa JC. The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading. Redox Biol. 2018 Apr; 14:164-177. PMID: 28942194.
      View in: PubMed
    6. Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkß and Sult1e1. PLoS One. 2017; 12(8):e0181052. PMID: 28797077.
      View in: PubMed
    7. McDaniel K, Huang L, Sato K, Wu N, Annable T, Zhou T, Ramos-Lorenzo S, Wan Y, Huang Q, Francis H, Glaser S, Tsukamoto H, Alpini G, Meng F. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury. J Biol Chem. 2017 07 07; 292(27):11336-11347. PMID: 28536261.
      View in: PubMed
    8. Yang Z, Liu Y, Qin L, Wu P, Xia Z, Luo M, Zeng Y, Tsukamoto H, Ju Z, Su D, Kang H, Xiao Z, Zheng S, Duan Z, Hu R, Wang Q, Pandol SJ, Han YP. Cathepsin H-Mediated Degradation of HDAC4 for Matrix Metalloproteinase Expression in Hepatic Stellate Cells: Implications of Epigenetic Suppression of Matrix Metalloproteinases in Fibrosis through Stabilization of Class IIa Histone Deacetylases. Am J Pathol. 2017 Apr; 187(4):781-797. PMID: 28157489.
      View in: PubMed
    9. Lai KKY, Kweon SM, Chi F, Hwang E, Kabe Y, Higashiyama R, Qin L, Yan R, Wu RP, Lai K, Fujii N, French S, Xu J, Wang JY, Murali R, Mishra L, Lee JS, Ntambi JM, Tsukamoto H. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by Stabilization of Low-Density Lipoprotein-Receptor-Related Proteins 5 and 6. Gastroenterology. 2017 05; 152(6):1477-1491. PMID: 28143772.
      View in: PubMed
    10. Zeybel M, Luli S, Sabater L, Hardy T, Oakley F, Leslie J, Page A, Moran Salvador E, Sharkey V, Tsukamoto H, Chu DCK, Singh US, Ponzoni M, Perri P, Di Paolo D, Mendivil EJ, Mann J, Mann DA. A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A. Mol Ther. 2017 01 04; 25(1):218-231. PMID: 28129116.
      View in: PubMed
    11. Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, Davila M, Nguyen BN, Stroehlein JR, Chen J, Kim SS, Levin H, Machida K, Tsukamoto H, Michaely P, Tzatsos A, Mishra B, Amdur R, Mishra L. Loss of the transforming growth factor-ß effector ß2-Spectrin promotes genomic instability. Hepatology. 2017 Feb; 65(2):678-693. PMID: 28114741.
      View in: PubMed
    12. Sadio A, Amaral AL, Nunes R, Ricardo S, Sarmento B, Almeida R, Tsukamoto H, das Neves J. A Mouse Intra-Intestinal Infusion Model and its Application to the Study of Nanoparticle Distribution. Front Physiol. 2016; 7:579. PMID: 27965585.
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    13. Su D, Nie Y, Zhu A, Chen Z, Wu P, Zhang L, Luo M, Sun Q, Cai L, Lai Y, Xiao Z, Duan Z, Zheng S, Wu G, Hu R, Tsukamoto H, Lugea A, Liu Z, Pandol SJ, Han YP. Vitamin D Signaling through Induction of Paneth Cell Defensins Maintains Gut Microbiota and Improves Metabolic Disorders and Hepatic Steatosis in Animal Models. Front Physiol. 2016; 7:498. PMID: 27895587.
      View in: PubMed
    14. Eguchi A, Lazaro RG, Wang J, Kim J, Povero D, Willliams B, Ho SB, Stärkel P, Schnabl B, Ohno-Machado L, Tsukamoto H, Feldstein AE. Extracellular vesicles released by hepatocytes from gastric infusion model of alcoholic liver disease contain a MicroRNA barcode that can be detected in blood. Hepatology. 2017 02; 65(2):475-490. PMID: 27639178.
      View in: PubMed
    15. Harrall KK, Kechris KJ, Tabakoff B, Hoffman PL, Hines LM, Tsukamoto H, Pravenec M, Printz M, Saba LM. Uncovering the liver's role in immunity through RNA co-expression networks. Mamm Genome. 2016 10; 27(9-10):469-84. PMID: 27401171; PMCID: PMC5002042.
    16. Kweon SM, Chi F, Higashiyama R, Lai K, Tsukamoto H. Wnt Pathway Stabilizes MeCP2 Protein to Repress PPAR-? in Activation of Hepatic Stellate Cells. PLoS One. 2016; 11(5):e0156111. PMID: 27214381; PMCID: PMC4877088.
    17. Mandrekar P, Bataller R, Tsukamoto H, Gao B. Alcoholic hepatitis: Translational approaches to develop targeted therapies. Hepatology. 2016 10; 64(4):1343-55. PMID: 26940353; PMCID: PMC5010788 [Available on 10/01/17].
    18. Puri P, Xu J, Vihervaara T, Katainen R, Ekroos K, Daita K, Min HK, Joyce A, Mirshahi F, Tsukamoto H, Sanyal AJ. Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese. J Lipid Res. 2016 06; 57(6):1017-28. PMID: 27020313; PMCID: PMC4878186 [Available on 06/01/17].
    19. Ma HY, Xu J, Liu X, Zhu Y, Gao B, Karin M, Tsukamoto H, Jeste DV, Grant I, Roberts AJ, Contet C, Geoffroy C, Zheng B, Brenner D, Kisseleva T. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. PMID: 27239399.
      View in: PubMed
    20. Gao B, Tsukamoto H. Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe? Gastroenterology. 2016 06; 150(8):1704-9. PMID: 26826669.
      View in: PubMed
    21. Chen J, Yao ZX, Chen JS, Gi YJ, Muñoz NM, Kundra S, Herlong HF, Jeong YS, Goltsov A, Ohshiro K, Mistry NA, Zhang J, Su X, Choufani S, Mitra A, Li S, Mishra B, White J, Rashid A, Wang AY, Javle M, Davila M, Michaely P, Weksberg R, Hofstetter WL, Finegold MJ, Shay JW, Machida K, Tsukamoto H, Mishra L. TGF-ß/ß2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome. J Clin Invest. 2016 Feb; 126(2):527-42. PMID: 26784546; PMCID: PMC4731168.
    22. Xu J, Chi F, Tsukamoto H. Notch, metabolism and macrophages. Oncotarget. 2015 Aug 21; 6(24):19942-3. PMID: 26343518; PMCID: PMC4652967.
    23. Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M. Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis. Pancreas. 2015 Aug; 44(6):882-7. PMID: 26166469; PMCID: PMC4503385.
    24. Fung E, Tsukamoto H. Morphogen-related therapeutic targets for liver fibrosis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S69-74. PMID: 26206577; PMCID: PMC4687970.
    25. Strauss E, Parise ER, Tsukamoto H. ALPD 2015, Preface. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S1. PMID: 26206575.
      View in: PubMed
    26. Xu J, Chi F, Tsukamoto H. Notch signaling and M1 macrophage activation in obesity-alcohol synergism. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S24-8. PMID: 26189984; PMCID: PMC4656026.
    27. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. PMID: 26198936; PMCID: PMC4512299.
    28. Lazaro R, Wu R, Tsukamoto H. Reply: To PMID 25132354. Hepatology. 2015 Jul; 62(1):324. PMID: 25302605.
      View in: PubMed
    29. Xu J, Chi F, Guo T, Punj V, Lee WN, French SW, Tsukamoto H. NOTCH reprograms mitochondrial metabolism for proinflammatory macrophage activation. J Clin Invest. 2015 Apr; 125(4):1579-90. PMID: 25798621; PMCID: PMC4396469.
    30. Tsukamoto H. Metabolic reprogramming and cell fate regulation in alcoholic liver disease. Pancreatology. 2015 Jul; 15(4 Suppl):S61-5. PMID: 25800177; PMCID: PMC4515387.
    31. Machida K, Feldman DE, Tsukamoto H. TLR4-dependent tumor-initiating stem cell-like cells (TICs) in alcohol-associated hepatocellular carcinogenesis. Adv Exp Med Biol. 2015; 815:131-44. PMID: 25427905.
      View in: PubMed
    32. Zhao N, Nizzi CP, Anderson SA, Wang J, Ueno A, Tsukamoto H, Eisenstein RS, Enns CA, Zhang AS. Low intracellular iron increases the stability of matriptase-2. J Biol Chem. 2015 Feb 13; 290(7):4432-46. PMID: 25550162; PMCID: PMC4326848.
    33. Lazaro R, Wu R, Lee S, Zhu NL, Chen CL, French SW, Xu J, Machida K, Tsukamoto H. Osteopontin deficiency does not prevent but promotes alcoholic neutrophilic hepatitis in mice. Hepatology. 2015 Jan; 61(1):129-40. PMID: 25132354; PMCID: PMC4280361.
    34. Page A, Paoli PP, Hill SJ, Howarth R, Wu R, Kweon SM, French J, White S, Tsukamoto H, Mann DA, Mann J. Alcohol directly stimulates epigenetic modifications in hepatic stellate cells. J Hepatol. 2015 Feb; 62(2):388-97. PMID: 25457206.
      View in: PubMed
    35. Chen P, Torralba M, Tan J, Embree M, Zengler K, Stärkel P, van Pijkeren JP, DePew J, Loomba R, Ho SB, Bajaj JS, Mutlu EA, Keshavarzian A, Tsukamoto H, Nelson KE, Fouts DE, Schnabl B. Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice. Gastroenterology. 2015 Jan; 148(1):203-214.e16. PMID: 25239591.
      View in: PubMed
    36. Xu J, Liu X, Gao B, Karin M, Tsukamoto H, Brenner D, Kisseleva T. New Approaches for Studying Alcoholic Liver Disease. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. PMID: 26594598.
      View in: PubMed
    37. Chen CL, Tsukamoto H, Machida K. Oncogenic signaling pathways and origins of tumor-initiating stem-like cells of hepatocellular carcinomas induced by hepatitis C virus, alcohol and/or obesity. Hepatol Int. 2014 Jul; 8(3):330-8. PMID: 26202636.
      View in: PubMed
    38. Medici V, Schroeder DI, Woods R, LaSalle JM, Geng Y, Shibata NM, Peerson J, Hodzic E, Dayal S, Tsukamoto H, Kharbanda KK, Tillman B, French SW, Halsted CH. Methylation and gene expression responses to ethanol feeding and betaine supplementation in the cystathionine beta synthase-deficient mouse. Alcohol Clin Exp Res. 2014 Jun; 38(6):1540-9. PMID: 24730561; PMCID: PMC4047166.
    39. Chen L, Charrier A, Zhou Y, Chen R, Yu B, Agarwal K, Tsukamoto H, Lee LJ, Paulaitis ME, Brigstock DR. Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells. Hepatology. 2014 Mar; 59(3):1118-29. PMID: 24122827; PMCID: PMC3943742.
    40. Tsukamoto H, Mishra L, Machida K. Alcohol, TLR4-TGF-ß antagonism, and liver cancer. Hepatol Int. 2014 Sep; 8 Suppl 2:408-12. PMID: 26201318; PMCID: PMC4900455.
    41. Chen CL, Tsukamoto H, Liu JC, Kashiwabara C, Feldman D, Sher L, Dooley S, French SW, Mishra L, Petrovic L, Jeong JH, Machida K. Reciprocal regulation by TLR4 and TGF-ß in tumor-initiating stem-like cells. J Clin Invest. 2013 Jul; 123(7):2832-49. PMID: 23921128; PMCID: PMC3696549.
    42. Kagawa T, Orii R, Hirose S, Arase Y, Shiraishi K, Mizutani A, Tsukamoto H, Mine T. Ursodeoxycholic acid stabilizes the bile salt export pump in the apical membrane in MDCK II cells. J Gastroenterol. 2014 May; 49(5):890-9. PMID: 23722250.
      View in: PubMed
    43. Hartmann P, Chen P, Wang HJ, Wang L, McCole DF, Brandl K, Stärkel P, Belzer C, Hellerbrand C, Tsukamoto H, Ho SB, Schnabl B. Deficiency of intestinal mucin-2 ameliorates experimental alcoholic liver disease in mice. Hepatology. 2013 Jul; 58(1):108-19. PMID: 23408358; PMCID: PMC3695050.
    44. Enns CA, Ahmed R, Wang J, Ueno A, Worthen C, Tsukamoto H, Zhang AS. Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway. PLoS One. 2013; 8(4):e60534. PMID: 23565256; PMCID: PMC3615098.
    45. Sugano K, Podolsky DK, Brenner DA, Michalopoulos G, Tsukamoto H. Kenji Fujiwara, MD, PhD. Gastroenterology. 2013 Apr; 144(4):661-3. PMID: 23499284.
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    46. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. PMID: 23086958; PMCID: PMC3516762.
    47. Perugorria MJ, Wilson CL, Zeybel M, Walsh M, Amin S, Robinson S, White SA, Burt AD, Oakley F, Tsukamoto H, Mann DA, Mann J. Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation. Hepatology. 2012 Sep; 56(3):1129-39. PMID: 22488473; PMCID: PMC3430805.
    48. Meng F, Glaser SS, Francis H, Yang F, Han Y, Stokes A, Staloch D, McCarra J, Liu J, Venter J, Zhao H, Liu X, Francis T, Swendsen S, Liu CG, Tsukamoto H, Alpini G. Epigenetic regulation of miR-34a expression in alcoholic liver injury. Am J Pathol. 2012 Sep; 181(3):804-17. PMID: 22841474; PMCID: PMC3432440.
    49. Zhong S, Xu J, Li P, Tsukamoto H. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84. PMID: 22829592; PMCID: PMC3442538.
    50. von Montfort C, Matias N, Fernandez A, Fucho R, Conde de la Rosa L, Martinez-Chantar ML, Mato JM, Machida K, Tsukamoto H, Murphy MP, Mansouri A, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial GSH determines the toxic or therapeutic potential of superoxide scavenging in steatohepatitis. J Hepatol. 2012 Oct; 57(4):852-9. PMID: 22687340; PMCID: PMC3445734.
    51. Kisseleva T, Cong M, Paik Y, Scholten D, Jiang C, Benner C, Iwaisako K, Moore-Morris T, Scott B, Tsukamoto H, Evans SM, Dillmann W, Glass CK, Brenner DA. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A. 2012 Jun 12; 109(24):9448-53. PMID: 22566629; PMCID: PMC3386114.
    52. Ueno A, Lazaro R, Wang PY, Higashiyama R, Machida K, Tsukamoto H. Mouse intragastric infusion (iG) model. Nat Protoc. 2012 Mar 29; 7(4):771-81. PMID: 22461066; PMCID: PMC4197794.
    53. Machida K, Chen CL, Liu JC, Kashiwabara C, Feldman D, French SW, Sher L, Hyeongnam JJ, Tsukamoto H. Cancer stem cells generated by alcohol, diabetes, and hepatitis C virus. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:19-22. PMID: 22320911; PMCID: PMC3306127.
    54. Tsukamoto H, Zhu NL, Wang J, Asahina K, Machida K. Morphogens and hepatic stellate cell fate regulation in chronic liver disease. J Gastroenterol Hepatol. 2012 Mar; 27 Suppl 2:94-8. PMID: 22320925; PMCID: PMC3337168.
    55. Yang MD, Chiang YM, Higashiyama R, Asahina K, Mann DA, Mann J, Wang CC, Tsukamoto H. Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor ? in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81. PMID: 22095555; PMCID: PMC3302956.
    56. Zhu NL, Asahina K, Wang J, Ueno A, Lazaro R, Miyaoka Y, Miyajima A, Tsukamoto H. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem. 2012 Mar 23; 287(13):10355-67. PMID: 22298767; PMCID: PMC3322997.
    57. Feldman DE, Chen C, Punj V, Tsukamoto H, Machida K. Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):829-34. PMID: 22207628; PMCID: PMC3271911.
    58. Erkan M, Adler G, Apte MV, Bachem MG, Buchholz M, Detlefsen S, Esposito I, Friess H, Gress TM, Habisch HJ, Hwang RF, Jaster R, Kleeff J, Klöppel G, Kordes C, Logsdon CD, Masamune A, Michalski CW, Oh J, Phillips PA, Pinzani M, Reiser-Erkan C, Tsukamoto H, Wilson J. StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut. 2012 Feb; 61(2):172-8. PMID: 22115911; PMCID: PMC3245897.
    59. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
    60. Tsukamoto H, Zhu NL, Asahina K, Mann DA, Mann J. Epigenetic cell fate regulation of hepatic stellate cells. Hepatol Res. 2011 Jul; 41(7):675-82. PMID: 21504520; PMCID: PMC4321904.
    61. Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol Clin Exp Res. 2011 Aug; 35(8):1509-18. PMID: 21463341; PMCID: PMC3131439.
    62. Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology. 2011 Mar; 53(3):983-95. PMID: 21294146; PMCID: PMC3078645.
    63. Xu J, Lai KKY, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-682. PMID: 21256905; PMCID: PMC3094601.
    64. Yan AW, Fouts DE, Brandl J, Stärkel P, Torralba M, Schott E, Tsukamoto H, Nelson KE, Brenner DA, Schnabl B. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology. 2011 Jan; 53(1):96-105. PMID: 21254165; PMCID: PMC3059122.
    65. Beaven SW, Wroblewski K, Wang J, Hong C, Bensinger S, Tsukamoto H, Tontonoz P. Liver X receptor signaling is a determinant of stellate cell activation and susceptibility to fibrotic liver disease. Gastroenterology. 2011 Mar; 140(3):1052-62. PMID: 21134374; PMCID: PMC3049833.
    66. Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, Ahmed R, Nizzi CP, Eisenstein RS, Tsukamoto H, Enns CA. Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood. 2011 Feb 03; 117(5):1687-99. PMID: 21115976; PMCID: PMC3056593.
    67. Zhong S, Machida K, Tsukamoto H, Johnson DL. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. PMID: 21106530; PMCID: PMC3024733.
    68. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 2010 Aug; 52(2):480-92. PMID: 20683948; PMCID: PMC3107125.
    69. Zhu NL, Wang J, Tsukamoto H. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. J Biol Chem. 2010 Oct 01; 285(40):30463-71. PMID: 20663865; PMCID: PMC2945539.
    70. Subramanian VS, Subramanya SB, Tsukamoto H, Said HM. Effect of chronic alcohol feeding on physiological and molecular parameters of renal thiamin transport. Am J Physiol Renal Physiol. 2010 Jul; 299(1):F28-34. PMID: 20427470; PMCID: PMC2904160.
    71. Esfandiari F, Medici V, Wong DH, Jose S, Dolatshahi M, Quinlivan E, Dayal S, Lentz SR, Tsukamoto H, Zhang YH, French SW, Halsted CH. Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. Hepatology. 2010 Mar; 51(3):932-41. PMID: 19957376; PMCID: PMC2898175.
    72. Ramani K, Yang H, Kuhlenkamp J, Tomasi L, Tsukamoto H, Mato JM, Lu SC. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation. Hepatology. 2010 Mar; 51(3):986-95. PMID: 20043323; PMCID: PMC2905860.
    73. Ciuclan L, Ehnert S, Ilkavets I, Weng HL, Gaitantzi H, Tsukamoto H, Ueberham E, Meindl-Beinker NM, Singer MV, Breitkopf K, Dooley S. TGF-beta enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I. J Hepatol. 2010 Mar; 52(3):407-16. PMID: 20129692.
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    74. Mann J, Chu DC, Maxwell A, Oakley F, Zhu NL, Tsukamoto H, Mann DA. MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis. Gastroenterology. 2010 Feb; 138(2):705-14, 714.e1-4. PMID: 19843474.
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    75. Yeligar SM, Machida K, Tsukamoto H, Kalra VK. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol. 2009 Nov 01; 183(9):5964-76. PMID: 19828633; PMCID: PMC3633447.
    76. Yeligar S, Tsukamoto H, Kalra VK. Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199. J Immunol. 2009 Oct 15; 183(8):5232-43. PMID: 19783678; PMCID: PMC3622549.
    77. Lu SC, Ramani K, Ou X, Lin M, Yu V, Ko K, Park R, Bottiglieri T, Tsukamoto H, Kanel G, French SW, Mato JM, Moats R, Grant E. S-adenosylmethionine in the chemoprevention and treatment of hepatocellular carcinoma in a rat model. Hepatology. 2009 Aug; 50(2):462-71. PMID: 19444874; PMCID: PMC2754739.
    78. Zhang AS, Yang F, Wang J, Tsukamoto H, Enns CA. Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. J Biol Chem. 2009 Aug 21; 284(34):22580-9. PMID: 19564337; PMCID: PMC2755665.
    79. Tsukamoto H, Machida K, Dynnyk A, Mkrtchyan H. "Second hit" models of alcoholic liver disease. Semin Liver Dis. 2009 May; 29(2):178-87. PMID: 19387917; PMCID: PMC4197797.
    80. Gao J, Chen J, Kramer M, Tsukamoto H, Zhang AS, Enns CA. Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab. 2009 Mar; 9(3):217-27. PMID: 19254567; PMCID: PMC2673483.
    81. Boros LG, Deng Q, Pandol SJ, Tsukamoto H, Go VL, Lee WN. Ethanol diversely alters palmitate, stearate, and oleate metabolism in the liver and pancreas of rats using the deuterium oxide single tracer. Pancreas. 2009 Mar; 38(2):e47-52. PMID: 19248221; PMCID: PMC4662660.
    82. Asahina K, Tsai SY, Li P, Ishii M, Maxson RE, Sucov HM, Tsukamoto H. Mesenchymal origin of hepatic stellate cells, submesothelial cells, and perivascular mesenchymal cells during mouse liver development. Hepatology. 2009 Mar; 49(3):998-1011. PMID: 19085956; PMCID: PMC2673117.
    83. Machida K, Tsukamoto H, Mkrtchyan H, Duan L, Dynnyk A, Liu HM, Asahina K, Govindarajan S, Ray R, Ou JH, Seki E, Deshaies R, Miyake K, Lai MM. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci U S A. 2009 Feb 03; 106(5):1548-53. PMID: 19171902; PMCID: PMC2635765.
    84. Tatsukawa H, Fukaya Y, Frampton G, Martinez-Fuentes A, Suzuki K, Kuo TF, Nagatsuma K, Shimokado K, Okuno M, Wu J, Iismaa S, Matsuura T, Tsukamoto H, Zern MA, Graham RM, Kojima S. Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1. Gastroenterology. 2009 May; 136(5):1783-95.e10. PMID: 19208340; PMCID: PMC4960455.
    85. Gordeuk VR, Diaz SF, Onojobi GO, Kasvosve I, Debebe Z, Edossa A, Pantin JM, Xiong S, Nekhai S, Nouraie M, Tsukamoto H, Taylor RE. Ferroportin Q248h, dietary iron, and serum ferritin in community African-Americans with low to high alcohol consumption. Alcohol Clin Exp Res. 2008 Nov; 32(11):1947-53. PMID: 18782341; PMCID: PMC3369540.
    86. Mello T, Nakatsuka A, Fears S, Davis W, Tsukamoto H, Bosron WF, Sanghani SP. Expression of carboxylesterase and lipase genes in rat liver cell-types. Biochem Biophys Res Commun. 2008 Sep 26; 374(3):460-4. PMID: 18639528; PMCID: PMC2566784.
    87. Xiong S, She H, Zhang AS, Wang J, Mkrtchyan H, Dynnyk A, Gordeuk VR, French SW, Enns CA, Tsukamoto H. Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Sep; 295(3):G512-21. PMID: 18599584; PMCID: PMC2536779.
    88. Tsukamoto H, She H, Hazra S, Cheng J, Wang J. Fat paradox of steatohepatitis. J Gastroenterol Hepatol. 2008 Mar; 23 Suppl 1:S104-7. PMID: 18336651.
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    89. Tsukamoto H, Mkrtchyan H, Dynnyk A. Intragastric ethanol infusion model in rodents. Methods Mol Biol. 2008; 447:33-48. PMID: 18369909.
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    90. Cheng JH, She H, Han YP, Wang J, Xiong S, Asahina K, Tsukamoto H. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G39-49. PMID: 18006602.
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    91. Berg T, Rountree CB, Lee L, Estrada J, Sala FG, Choe A, Veltmaat JM, De Langhe S, Lee R, Tsukamoto H, Crooks GM, Bellusci S, Wang KS. Fibroblast growth factor 10 is critical for liver growth during embryogenesis and controls hepatoblast survival via beta-catenin activation. Hepatology. 2007 Oct; 46(4):1187-97. PMID: 17668871; PMCID: PMC3494299.
    92. Gukovsky I, Lugea A, Shahsahebi M, Cheng JH, Hong PP, Jung YJ, Deng QG, French BA, Lungo W, French SW, Tsukamoto H, Pandol SJ. A rat model reproducing key pathological responses of alcoholic chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2008 Jan; 294(1):G68-79. PMID: 17884979.
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    93. Tsukamoto H. Conceptual importance of identifying alcoholic liver disease as a lifestyle disease. J Gastroenterol. 2007 Aug; 42(8):603-9. PMID: 17701122.
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    94. Han YP, Yan C, Zhou L, Qin L, Tsukamoto H. A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem. 2007 Apr 27; 282(17):12928-39. PMID: 17322299; PMCID: PMC2376818.
    95. Chen L, Xiong S, She H, Lin SW, Wang J, Tsukamoto H. Iron causes interactions of TAK1, p21ras, and phosphatidylinositol 3-kinase in caveolae to activate IkappaB kinase in hepatic macrophages. J Biol Chem. 2007 Feb 23; 282(8):5582-8. PMID: 17172471.
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    96. Tsukamoto H. Epigenetic mechanism of stellate cell trans-differentiation. J Hepatol. 2007 Feb; 46(2):352-3. PMID: 17161490.
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    97. Pandol SJ, Tsukamoto H. Action plan for enhancing global collaboration on alcoholic liver and pancreatic diseases: white paper. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S109-10. PMID: 16958661.
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    98. Tsukamoto H, She H, Hazra S, Cheng J, Miyahara T. Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. J Gastroenterol Hepatol. 2006 Oct; 21 Suppl 3:S102-5. PMID: 16958658.
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    99. Tsukamoto H. Fat paradox in liver disease. Keio J Med. 2005 Dec; 54(4):190-2. PMID: 16452829.
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    100. Tsukamoto H. Adipogenic phenotype of hepatic stellate cells. Alcohol Clin Exp Res. 2005 Nov; 29(11 Suppl):132S-133S. PMID: 16344597.
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    101. Yavrom S, Chen L, Xiong S, Wang J, Rippe RA, Tsukamoto H. Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem. 2005 Dec 09; 280(49):40650-9. PMID: 16216869.
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    102. Deng QG, She H, Cheng JH, French SW, Koop DR, Xiong S, Tsukamoto H. Steatohepatitis induced by intragastric overfeeding in mice. Hepatology. 2005 Oct; 42(4):905-14. PMID: 16175602.
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    103. Yang MD, Deng QG, Chen S, Xiong S, Koop D, Tsukamoto H. Hepatoprotective mechanisms of Yan-gan-wan. Hepatol Res. 2005 Aug; 32(4):202-12. PMID: 16107322.
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    104. Sussman S, Runyon BA, Hernandez R, Magallanes M, Mendler M, Yuan JM, Tsukamoto H. A pilot study of an alcoholic liver disease recurrence prevention education program in hospitalized patients with advanced liver disease. Addict Behav. 2005 Mar; 30(3):465-73. PMID: 15718064.
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    105. She H, Xiong S, Hazra S, Tsukamoto H. Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem. 2005 Feb 11; 280(6):4959-67. PMID: 15537655.
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    106. Minagawa M, Deng Q, Liu ZX, Tsukamoto H, Dennert G. Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-alpha during alcohol consumption. Gastroenterology. 2004 May; 126(5):1387-99. PMID: 15131799.
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    107. Veal N, Hsieh CL, Xiong S, Mato JM, Lu S, Tsukamoto H. Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol. 2004 Aug; 287(2):G352-62. PMID: 15064230.
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    108. Xiong S, She H, Tsukamoto H. Signaling role of iron in NF-kappa B activation in hepatic macrophages. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S36. PMID: 14960188.
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    109. Hazra S, Miyahara T, Rippe RA, Tsukamoto H. PPAR Gamma and Hepatic Stellate Cells. Comp Hepatol. 2004 Jan 14; 3 Suppl 1:S7. PMID: 14960159.
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    110. Hazra S, Xiong S, Wang J, Rippe RA, Krishna V, Chatterjee K, Tsukamoto H. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem. 2004 Mar 19; 279(12):11392-401. PMID: 14702344.
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    111. Sung CK, She H, Xiong S, Tsukamoto H. Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2004 May; 286(5):G722-9. PMID: 14656714.
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    112. Han YP, Zhou L, Wang J, Xiong S, Garner WL, French SW, Tsukamoto H. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem. 2004 Feb 06; 279(6):4820-8. PMID: 14617627; PMCID: PMC2430939.
    113. Tao N, Sussman S, Nieto J, Tsukamoto H, Yuan JM. Demographic characteristics of hospitalized patients with alcoholic liver disease and pancreatitis in los angeles county. Alcohol Clin Exp Res. 2003 Nov; 27(11):1798-804. PMID: 14634496.
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    114. Zhang AS, Xiong S, Tsukamoto H, Enns CA. Localization of iron metabolism-related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes. Blood. 2004 Feb 15; 103(4):1509-14. PMID: 14563638.
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    115. Xiong S, She H, Sung CK, Tsukamoto H. Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol. 2003 Jun; 30(2):107-13. PMID: 12957294.
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    116. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. PMID: 12637578.
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    117. Tsukamoto H. Redox regulation of cytokine expression in Kupffer cells. Antioxid Redox Signal. 2002 Oct; 4(5):741-8. PMID: 12470501.
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    118. Neuman MG, Katz GG, Malkiewicz IM, Mathurin P, Tsukamoto H, Adachi M, Ishii H, Colell A, García-Ruiz C, Fernández-Checa JC, Casey CA. Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol. 2002 Oct; 28(2):117-28. PMID: 12457943.
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    119. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. PMID: 12181188.
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    120. Lu SC, Tsukamoto H, Mato JM. Role of abnormal methionine metabolism in alcoholic liver injury. Alcohol. 2002 Jul; 27(3):155-62. PMID: 12163143.
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    121. Mathurin P, Xiong S, Kharbanda KK, Veal N, Miyahara T, Motomura K, Rippe RA, Bachem MG, Tsukamoto H. IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2002 Jun; 282(6):G981-90. PMID: 12016123.
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    122. Tsukamoto H. Iron regulation of hepatic macrophage TNFalpha expression. Free Radic Biol Med. 2002 Feb 15; 32(4):309-13. PMID: 11841920.
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    123. Sussman S, Dent CW, Skara S, de Calice P, Tsukamoto H. Alcoholic liver disease (ALD): a new domain for prevention efforts. Subst Use Misuse. 2002; 37(14):1887-904. PMID: 12511057.
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