Lily Dara, MD

Title(s)Assistant Professor of Medicine
SchoolKeck School of Medicine of Usc
AddressHMR 512 2011 Zonal Avenue Mail Code:9091
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 5576
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    Collapse Biography 
    Collapse Awards and Honors
    American Association for the Study of Liver Disease2007Resident Scholar Award
    American Association for the Study of Liver Disease2011Presidential Poster of Distinction
    Keck School of Medicine of USC2015USC RCLD Junior Faculty Transition Award
    NIH, NIDDK2016  - 2021K08 Mentored Clinical Scientist Development Award

    Collapse Overview 
    Collapse Overview
    Dr. Dara is an NIH funded physician-scientist and clinician. She completed her Gastroenterology training at USC, is board certified in Internal Medicine and Gastroenterology and practices primarily as a hepatologist (liver specialist). Her clinical work is focused on autoimmune liver diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC) and their variant syndromes. She is currently practicing at the Los Angeles General Medical Center where she sees patients with liver disease (including alcohol associated liver disease, fatty liver disease, viral hepatitis, liver failure, cirrhosis of the liver, drug-induced liver disease, metabolic and genetic disorders of the liver among many others) on the inpatient liver service and in the subspeciality liver clinics. At the Keck Hospital of USC she performs procedures such as endoscopies and colonoscopies in the new outpatient endoscopy unit. Her research focuses on disorders of the liver including drug induced liver injury and hepatotoxicity from medications, drugs, toxins, and herbal supplements in translational animal models as well as humans. She participates as an investigator on the NIH’s Drug Induced Liver Injury Network (DILIN) and is a reviewer for the LiverTox website. Additionally, she studies Autoimmune Hepatitis and PBC outcomes in patients with a focus on understanding the impact of ace and ethnicity, in particular Hispanic/Latinx ethnicity on outcomes.

    Collapse Research 
    Collapse Research Activities and Funding
    Role of RIPK1 and RIPK3 in liver injury.
    NIH K08DK109141Jul 1, 2016 - Nov 30, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors. Hepatol Commun. 2024 09 01; 8(9). Fontana RJ, Li YJ, Chen V, Kleiner D, Stolz A, Odin J, Vuppalanchi R, Gu J, Dara L, Barnhart H, Drug-Induced Liver Injury Network. PMID: 39185906; PMCID: PMC11357698.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. Evaluation of markers of immunity in different metastatic immune microenvironments suggests more suppression within breast to liver metastases in breast cancer. Breast Cancer Res Treat. 2024 Jul; 206(2):245-259. Hsu R, Al-Zubeidy B, Flores D, Nazarian A, Baugh A, Gonzalez E, Castanon S, Xiu J, Kang I, Spicer D, Lenz HJ, Dara L, Ademuyiwa FO, Korn WM, Irshad S, Chan IS, Roussos Torres ET. PMID: 38643348; PMCID: PMC11182800.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    3. Innate and adaptive immune cell interaction drives inflammasome activation and hepatocyte apoptosis in murine liver injury from immune checkpoint inhibitors. Cell Death Dis. 2024 Feb 14; 15(2):140. Shojaie L, Bogdanov JM, Alavifard H, Mohamed MG, Baktash A, Ali M, Mahov S, Murray S, Kanel GC, Liu ZX, Ito F, In GK, Merchant A, Stohl W, Dara L. PMID: 38355725; PMCID: PMC10866933.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. A 68-Year-Old Woman With Unexplained Liver Enzyme Elevation and Active Chronic Hepatitis: Beware of Drug-Induced Autoimmune-Like Hepatitis. Gastroenterology. 2024 02; 166(2):259-266.e1. Dara L, Ghabril M, Phillips E, Kleiner D, Chalasani N. PMID: 37797776.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Etiology of end-stage liver cirrhosis impacts hepatic natural killer cell heterogenicity. Front Immunol. 2023; 14:1137034. Maretti-Mira AC, Salomon MP, Hsu AM, Dara L, Golden-Mason L. PMID: 37063898; PMCID: PMC10098346.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. No Necroptosis in Hepatocytes: The Final Nail in the Coffin? Gastroenterology. 2022 12; 163(6):1492-1495. Dara L. PMID: 36155192.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Autophagy impairment in liver CD11c+ cells promotes non-alcoholic fatty liver disease through production of IL-23. Nat Commun. 2022 03 17; 13(1):1440. Galle-Treger L, Helou DG, Quach C, Howard E, Hurrell BP, Muench GRA, Shafiei-Jahani P, Painter JD, Iorga A, Dara L, Emamaullee J, Golden-Mason L, Rosen HR, Soroosh P, Akbari O. PMID: 35301333; PMCID: PMC8931085.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    8. Acute Hepatitis A and Hepatitis B Coinfection. ACG Case Rep J. 2021 Nov; 8(11):e00702. Hiramoto B, Liu Y, Dara L, Zhou K. PMID: 34820469; PMCID: PMC8608259.
      View in: PubMed   Mentions: 2  
    9. Mechanisms of immune checkpoint inhibitor-mediated liver injury. Acta Pharm Sin B. 2021 Dec; 11(12):3727-3739. Shojaie L, Ali M, Iorga A, Dara L. PMID: 35024302; PMCID: PMC8727893.
      View in: PubMed   Mentions: 21  
    10. We Are Not Immune: Racial and Ethnic Disparities in Autoimmune Liver Diseases. Hepatology. 2021 11; 74(5):2876-2887. Lee BT, Tana MM, Kahn JA, Dara L. PMID: 34056734.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    11. Interaction of RIPK1 and A20 modulates MAPK signaling in murine acetaminophen toxicity. J Biol Chem. 2021 Jan-Jun; 296:100300. Iorga A, Donovan K, Shojaie L, Johnson H, Kwok J, Suda J, Lee BT, Aghajan M, Shao L, Liu ZX, Dara L. PMID: 33460648; PMCID: PMC7948960.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. Cell Death in Liver Diseases: A Review. Int J Mol Sci. 2020 Dec 18; 21(24). Shojaie L, Iorga A, Dara L. PMID: 33353156; PMCID: PMC7766597.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    13. IgG:IgM Ratios of Liver Plasma Cells Reveal Similar Phenotypes of Primary Biliary Cholangitis With and Without Features of Autoimmune Hepatitis. Clin Gastroenterol Hepatol. 2021 02; 19(2):397-399. Lee BT, Wang Y, Yang A, Han H, Yuan L, Donovan J, Kaplowitz N, Kanel G, Kahn J, Dara L. PMID: 31751773; PMCID: PMC7231645.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    14. Cell death in drug-induced liver injury. Adv Pharmacol. 2019; 85:31-74. Iorga A, Dara L. PMID: 31307591.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    15. The Receptor Interacting Protein Kinases in the Liver. Semin Liver Dis. 2018 02; 38(1):73-86. Dara L. PMID: 29471568; PMCID: PMC5864113.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis. Int J Mol Sci. 2017 May 09; 18(5). Iorga A, Dara L, Kaplowitz N. PMID: 28486401; PMCID: PMC5454931.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    17. Questions and controversies: the role of necroptosis in liver disease. Cell Death Discov. 2016; 2:16089. Dara L, Liu ZX, Kaplowitz N. PMID: 27924226; PMCID: PMC5136616.
      View in: PubMed   Mentions: 52  
    18. A murder mystery in the liver: who done it and how? J Clin Invest. 2016 11 01; 126(11):4068-4071. Dara L, Liu ZX, Kaplowitz N. PMID: 27760053; PMCID: PMC5096892.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    19. Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-κB. J Immunol. 2016 10 15; 197(8):3120-3129. Suda J, Dara L, Yang L, Aghajan M, Song Y, Kaplowitz N, Liu ZX. PMID: 27605011; PMCID: PMC5101131.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    20. The many faces of RIPK3: What about NASH? Hepatology. 2016 11; 64(5):1411-1413. Dara L, Kaplowitz N. PMID: 27338154; PMCID: PMC5074903.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    21. Randomized trial of 1-week versus 2-week intervals for endoscopic ligation in the treatment of patients with esophageal variceal bleeding. Hepatology. 2016 08; 64(2):549-55. Sheibani S, Khemichian S, Kim JJ, Hou L, Yan AW, Buxbaum J, Dara L, Laine L. PMID: 27082942; PMCID: PMC4956532.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    22. Reply. Hepatology. 2016 07; 64(1):312-3. Dara L, Kaplowitz N. PMID: 26418131.
      View in: PubMed   Mentions:    Fields:    
    23. Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int. 2016 Feb; 36(2):158-65. Dara L, Liu ZX, Kaplowitz N. PMID: 26484420; PMCID: PMC4718752.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    24. Reply. Hepatology. 2016 07; 64(1):308-9. Dara L, Kaplowitz N. PMID: 26390377.
      View in: PubMed   Mentions:    Fields:    
    25. Receptor interacting protein kinase 1 mediates murine acetaminophen toxicity independent of the necrosome and not through necroptosis. Hepatology. 2015 Dec; 62(6):1847-57. Dara L, Johnson H, Suda J, Win S, Gaarde W, Han D, Kaplowitz N. PMID: 26077809; PMCID: PMC4681652.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    26. Targeting signal transduction pathways which regulate necrosis in acetaminophen hepatotoxicity. J Hepatol. 2015 Jul; 63(1):5-7. Kaplowitz N, Win S, Than TA, Liu ZX, Dara L. PMID: 25770661.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    27. Cellular uptake and cytotoxicity of a near-IR fluorescent corrole-TiO2 nanoconjugate. J Inorg Biochem. 2014 Nov; 140:39-44. Blumenfeld CM, Sadtler BF, Fernandez GE, Dara L, Nguyen C, Alonso-Valenteen F, Medina-Kauwe L, Moats RA, Lewis NS, Grubbs RH, Gray HB, Sorasaenee K. PMID: 25061689; PMCID: PMC4998051.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    28. MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. Hepatology. 2013 Jun; 57(6):2299-313. Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC. PMID: 23325601; PMCID: PMC3642222.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansCells
    29. Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria. Trends Pharmacol Sci. 2013 Apr; 34(4):243-53. Han D, Dara L, Win S, Than TA, Yuan L, Abbasi SQ, Liu ZX, Kaplowitz N. PMID: 23453390; PMCID: PMC3622802.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    30. Dynamic adaptation of liver mitochondria to chronic alcohol feeding in mice: biogenesis, remodeling, and functional alterations. J Biol Chem. 2012 Dec 07; 287(50):42165-79. Han D, Ybanez MD, Johnson HS, McDonald JN, Mesropyan L, Sancheti H, Martin G, Martin A, Lim AM, Dara L, Cadenas E, Tsukamoto H, Kaplowitz N. PMID: 23086958; PMCID: PMC3516762.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    31. The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63. Dara L, Ji C, Kaplowitz N. PMID: 21384408; PMCID: PMC3082587.
      View in: PubMed   Mentions: 156     Fields:    Translation:HumansAnimalsCells
    32. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 07; 14(45):6999-7004. Dara L, Hewett J, Lim JK. PMID: 19058338; PMCID: PMC2773866.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans