Ebrahim Zandi, PhD

Title(s)Associate Professor of Molecular Microbiology & Immunology
SchoolKeck School of Medicine of Usc
AddressNTT 6429 1441 Eastlake Avenue
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 865 0644
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    Dr. Ebrahim (Ebi) Zandi is Associate Professor of Molecular Microbiology & immunology at USC Keck School of Medicine. He received his Ph.D. in Biochemistry in 1995 from the California Institute of Technology (CalTech, Pasadena, CA). He has made significant contributions to the field of NF-kB and IKK signal transduction pathways. He has been honored with several awards including Leukemia and Lymphoma Society of America Special Fellow Award, The V Foundation, and Stop Cancer. In addition, he is the first PEW Scholar Fellow (2001-2004) at USC. Furthermore, He has established Mass Spectrometry-based Proteomics at KSOM, and is the founding director of the USC Proteomics Center of Excellence. Currently, his research involves the use of proteomics and other omic technologies to understand the function of microbiome in Ulcerative Colitis as well as chemo- and immune-therapy in cancer patients.

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    Mechanisms of IkappaB Kinase Regulation
    NIH R01GM065325Aug 1, 2002 - Jul 31, 2009
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Midlife Study of the Louisville Twins: Connecting Cognitive Development to Biological and Cognitive Aging. Behav Genet. 2020 03; 50(2):73-83. Beam CR, Turkheimer E, Finkel D, Levine ME, Zandi E, Guterbock TM, Giangrande EJ, Ryan L, Pasquenza N, Davis DW. PMID: 31820295; PMCID: PMC7033012.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    2. Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-β signaling. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4245-E4254. Tsai YL, Ha DP, Zhao H, Carlos AJ, Wei S, Pun TK, Wu K, Zandi E, Kelly K, Lee AS. PMID: 29654145; PMCID: PMC5939063.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    3. A perillyl alcohol-conjugated analog of 3-bromopyruvate without cellular uptake dependency on monocarboxylate transporter 1 and with activity in 3-BP-resistant tumor cells. Cancer Lett. 2017 08 01; 400:161-174. Chen TC, Yu J, Nouri Nigjeh E, Wang W, Myint PT, Zandi E, Hofman FM, Schönthal AH. PMID: 28450161.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    4. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez SF, Zandi E. PMID: 26807013; PMCID: PMC4720167.
      View in: PubMed   Mentions: 6  
    5. Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis. Immunity. 2015 Aug 18; 43(2):251-63. Yang R, Qu C, Zhou Y, Konkel JE, Shi S, Liu Y, Chen C, Liu S, Liu D, Chen Y, Zandi E, Chen W, Zhou Y, Shi S. PMID: 26275994; PMCID: PMC4731232.
      View in: PubMed   Mentions: 175     Fields:    Translation:HumansAnimalsCells
    6. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. PMID: 26221961; PMCID: PMC4519330.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    7. Viral pseudo-enzymes activate RIG-I via deamidation to evade cytokine production. Mol Cell. 2015 Apr 02; 58(1):134-46. He S, Zhao J, Song S, He X, Minassian A, Zhou Y, Zhang J, Brulois K, Wang Y, Cabo J, Zandi E, Liang C, Jung JU, Zhang X, Feng P. PMID: 25752576; PMCID: PMC4385502.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    8. Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression. PLoS One. 2015; 10(2):e0117758. Patel N, Itakura T, Jeong S, Liao CP, Roy-Burman P, Zandi E, Groshen S, Pinski J, Coetzee GA, Gross ME, Fini ME. PMID: 25693195; PMCID: PMC4333349.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    9. Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. Antioxid Redox Signal. 2015 Jan 20; 22(3):259-74. Yang H, Li TW, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 25226451; PMCID: PMC4283066.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    10. Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration. Cell Stem Cell. 2014 Jul 03; 15(1):66-78. Liu Y, Yang R, Liu X, Zhou Y, Qu C, Kikuiri T, Wang S, Zandi E, Du J, Ambudkar IS, Shi S. PMID: 24726192; PMCID: PMC4082757.
      View in: PubMed   Mentions: 119     Fields:    Translation:HumansAnimalsCells
    11. CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features. Mol Cancer Res. 2014 Apr; 12(4):607-21. Geary LA, Nash KA, Adisetiyo H, Liang M, Liao CP, Jeong JH, Zandi E, Roy-Burman P. PMID: 24464914; PMCID: PMC3989391.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    12. Novel Phosphorylations of IKKγ/NEMO. mBio. 2012 Nov 06; 3(6):e00411-12. Lee SH, Toth Z, Wong LY, Brulois K, Nguyen J, Lee JY, Zandi E, Jung JU. PMID: 23131831; PMCID: PMC3487776.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    13. Site-specific modification of adeno-associated viruses via a genetically engineered aldehyde tag. Small. 2013 Feb 11; 9(3):421-9. Liu Y, Fang Y, Zhou Y, Zandi E, Lee CL, Joo KI, Wang P. PMID: 23038676.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    14. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012 Oct 02; 109(40):16348-53. Xu S, Butkevich AN, Yamada R, Zhou Y, Debnath B, Duncan R, Zandi E, Petasis NA, Neamati N. PMID: 22988091; PMCID: PMC3479552.
      View in: PubMed   Mentions: 103     Fields:    Translation:HumansAnimalsCells
    15. Autophagy protein Rubicon mediates phagocytic NADPH oxidase activation in response to microbial infection or TLR stimulation. Cell Host Microbe. 2012 Mar 15; 11(3):264-76. Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. PMID: 22423966; PMCID: PMC3616771.
      View in: PubMed   Mentions: 89     Fields:    Translation:HumansAnimalsCells
    16. Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs). J Med Chem. 2011 Apr 28; 54(8):2902-14. Yamada R, Cao X, Butkevich AN, Millard M, Odde S, Mordwinkin N, Gundla R, Zandi E, Louie SG, Petasis NA, Neamati N. PMID: 21443194.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    17. Novel function and intracellular localization of methionine adenosyltransferase 2beta splicing variants. J Biol Chem. 2010 Jun 25; 285(26):20015-21. Xia M, Chen Y, Wang LC, Zandi E, Yang H, Bemanian S, Martínez-Chantar ML, Mato JM, Lu SC. PMID: 20421296; PMCID: PMC2888413.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    18. DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst). 2010 Apr 04; 9(4):429-37. Gu J, Li S, Zhang X, Wang LC, Niewolik D, Schwarz K, Legerski RJ, Zandi E, Lieber MR. PMID: 20117966; PMCID: PMC2847011.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    19. Regulation of I(kappa)B kinase complex by phosphorylation of (gamma)-binding domain of I(kappa)B kinase (beta) by Polo-like kinase 1. J Biol Chem. 2008 Dec 19; 283(51):35354-67. Higashimoto T, Chan N, Lee YK, Zandi E. PMID: 18957422; PMCID: PMC2602907.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    20. A simple and inexpensive on-column frit fabrication method for fused-silica capillaries for increased capacity and versatility in LC-MS/MS applications. Proteomics. 2008 May; 8(9):1758-61. Wang LC, Okitsu CY, Kochounian H, Rodriguez A, Hsieh CL, Zandi E. PMID: 18384106.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    21. Identification of galectin-3-binding protein as a factor secreted by tumor cells that stimulates interleukin-6 expression in the bone marrow stroma. J Biol Chem. 2008 Jul 04; 283(27):18573-81. Fukaya Y, Shimada H, Wang LC, Zandi E, DeClerck YA. PMID: 18450743.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansCells
    22. A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity. J Biol Chem. 2007 Jul 20; 282(29):21487-96. Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y. PMID: 17526490.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    23. DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem. 2006 Nov 10; 281(45):33900-9. Niewolik D, Pannicke U, Lu H, Ma Y, Wang LC, Kulesza P, Zandi E, Lieber MR, Schwarz K. PMID: 16914548.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    24. TNFalpha induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways. Cytokine. 2006 Apr; 34(1-2):39-50. Higashimoto T, Panopoulos A, Hsieh CL, Zandi E. PMID: 16723255.
      View in: PubMed   Mentions: 9  Translation:HumansCells
    25. Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta. J Biol Chem. 2006 Jun 02; 281(22):15268-76. Schomer-Miller B, Higashimoto T, Lee YK, Zandi E. PMID: 16597623.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    26. Identification of post-translational modifications by blind search of mass spectra. Nat Biotechnol. 2005 Dec; 23(12):1562-7. Tsur D, Tanner S, Zandi E, Bafna V, Pevzner PA. PMID: 16311586.
      View in: PubMed   Mentions: 89     Fields:    Translation:Cells
    27. InsPecT: identification of posttranslationally modified peptides from tandem mass spectra. Anal Chem. 2005 Jul 15; 77(14):4626-39. Tanner S, Shu H, Frank A, Wang LC, Zandi E, Mumby M, Pevzner PA, Bafna V. PMID: 16013882.
      View in: PubMed   Mentions: 245     Fields:    Translation:Cells
    28. Identification of post-translational modifications via blind search of mass-spectra. Proc IEEE Comput Syst Bioinform Conf. 2005; 157-66. Tsur D, Tanner S, Zandi E, Bafna V, Pevzner PA. PMID: 16447973.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    29. Tumor necrosis factor alpha-dependent drug resistance to purine and pyrimidine analogues in human colon tumor cells mediated through IKK. J Biol Chem. 2005 Mar 04; 280(9):7634-44. Wang LC, Okitsu CY, Zandi E. PMID: 15611081.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    30. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28; 280(4):2912-23. Panopoulos A, Harraz M, Engelhardt JF, Zandi E. PMID: 15550384.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    31. Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem. 2003 May 16; 278(20):17646-54. Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi C, Tsukamoto H. PMID: 12637578.
      View in: PubMed   Mentions: 67     Fields:    Translation:AnimalsCells
    32. Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G719-26. She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. PMID: 12181188.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    33. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001 Sep 28; 276(39):36320-6. Miller BS, Zandi E. PMID: 11470787.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    34. Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. J Biol Chem. 2001 Aug 10; 276(32):30188-98. Sanlioglu S, Williams CM, Samavati L, Butler NS, Wang G, McCray PB, Ritchie TC, Hunninghake GW, Zandi E, Engelhardt JF. PMID: 11402028.
      View in: PubMed   Mentions: 132     Fields:    Translation:HumansAnimalsCells
    35. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol. 1999 Jul; 19(7):4547-51. Zandi E, Karin M. PMID: 10373503; PMCID: PMC84252.
      View in: PubMed   Mentions: 77     Fields:    Translation:Humans
    36. Fluid shear stress activation of IkappaB kinase is integrin-dependent. J Biol Chem. 1998 Nov 13; 273(46):30544-9. Bhullar IS, Li YS, Miao H, Zandi E, Kim M, Shyy JY, Chien S. PMID: 9804824.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    37. IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature. 1998 Sep 17; 395(6699):297-300. Rothwarf DM, Zandi E, Natoli G, Karin M. PMID: 9751060.
      View in: PubMed   Mentions: 278     Fields:    Translation:HumansCells
    38. Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate. Science. 1998 Aug 28; 281(5381):1360-3. Zandi E, Chen Y, Karin M. PMID: 9721103.
      View in: PubMed   Mentions: 137     Fields:    Translation:HumansAnimalsCells
    39. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J Biol Chem. 1998 Aug 14; 273(33):21132-6. Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. PMID: 9694868.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansCells
    40. The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell. 1997 Oct 17; 91(2):243-52. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. PMID: 9346241.
      View in: PubMed   Mentions: 490     Fields:    Translation:HumansCells
    41. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature. 1997 Aug 07; 388(6642):548-54. DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. PMID: 9252186.
      View in: PubMed   Mentions: 566     Fields:    Translation:HumansCells
    42. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Mol Cell Biol. 1997 Aug; 17(8):4687-95. Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. PMID: 9234725; PMCID: PMC232321.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    43. Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. Mol Cell Biol. 1997 Jun; 17(6):3094-102. Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. PMID: 9154808; PMCID: PMC232162.
      View in: PubMed   Mentions: 158     Fields:    Translation:AnimalsCells
    44. Nuclear entry, oligomerization, and DNA binding of the Drosophila heat shock transcription factor are regulated by a unique nuclear localization sequence. Genes Dev. 1997 May 15; 11(10):1299-314. Zandi E, Tran TN, Chamberlain W, Parker CS. PMID: 9171374.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    45. AP-1 function and regulation. Curr Opin Cell Biol. 1997 Apr; 9(2):240-6. Karin M, Liu Zg, Zandi E. PMID: 9069263.
      View in: PubMed   Mentions: 705     Fields:    Translation:HumansAnimals
    46. The yeast and mammalian Ras pathways control transcription of heat shock genes independently of heat shock transcription factor. Mol Cell Biol. 1994 Jul; 14(7):4929-37. Engelberg D, Zandi E, Parker CS, Karin M. PMID: 8007989; PMCID: PMC358865.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    47. Zinc finger mutations that alter domain interactions in the glucocorticoid receptor. J Mol Biol. 1993 Mar 05; 230(1):124-36. Zandi E, Galli I, Döbbeling U, Rusconi S. PMID: 8450530.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
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