Maria C. Edman-Woolcott, PhD

Title(s)Assistant Professor of Research Ophthalmology
SchoolKeck School of Medicine of Usc
AddressMCA 351 1333 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
Phone+1 323 442 7998
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    Collapse Biography 
    Collapse Education and Training
    USC School of Pharmacy, Los Angeles, CAPost-Doc2010
    Kalmar University, Växjö, SwedenPhD2007Biological Sciences
    Linköping University, Linköping, SwedenBS2002Medical Biology
    Collapse Awards and Honors
    Sjögren’s Syndrome Foundation2015  - 2017Sjögren’s Syndrome Foundation Research Award

    Collapse Overview 
    Collapse Overview
    Maria Edman has a background in biomedical research with a B.Sc in Medical Biology from Linköping University, Sweden, and a PhD in Biomedical Sciences from Kalmar University, Sweden. During her graduate studies she focused on the regulation of secretion of tears from the lacrimal gland, particularly the role of the purinergic adenosine receptors. After receiving her PhD, she continued her work in lacrimal gland biology under guidance of Dr. Sarah Hamm-Alvarez at the USC School of Pharmacy. Her initial postdoctoral studies were focused on the vesicular networks responsible for protein secretion from the lacrimal gland. Dr. Edman joined the Roski Eye institute in 2015, as a research associate.

    In recent years her research focus has shifted more towards Sjögren’s Syndrome, a systemic autoimmune disease that causes inflammation in exocrine glands, including the lacrimal gland. Patients with this disease suffer from dry eye and dry mouth in addition to systemic symptoms including joint pain and fatigue. Although Sjögren’s Syndrome is the second most common autoimmune disease, affecting up to 4 million Americans, it is unfortunately an underserved disease, which is both hard to diagnose due to an overlap of symptoms with other autoimmune and dry eye conditions and a and hard to treat due to a lack of specific therapies. Utilizing mouse models of Sjögren’s Syndrome Dr. Edman has been exploring the tear protein composition and identified several proteins that have an altered abundance or activity in the Sjögren’s Syndrome mice compared to healthy mice. The potential of these proteins as diagnostic biomarkers for Sjögren’s Syndrome has been confirmed in Sjögren’s patients. In collaboration with Dr. Hamm-Alvarez and Dr. Mackay from the USC School of Pharmacy, she has been exploring several new drug delivery strategies of traditional immunosuppressing drugs that specifically target the lacrimal glands. These delivery systems may reduce the systemic toxicity of the drugs and make them more effective for Sjögren’s Syndrome treatment.

    Research Interests:
    Dr. Edman’s primary research interest to increase the understanding of the interplay between the diseased lacrimal gland, the tears and the ocular surface, as well as identifying new biomarkers and therapeutic targets for Sjögren’s Syndrome and other dry eye conditions.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multidimensional Separation Using HILIC and SCX Pre-fractionation for RP LC-MS/MS Platform with Automated Exclusion List-based MS Data Acquisition with Increased Protein Quantification. J Proteomics Bioinform. 2015 Nov; 8(11):260-265. Zhou Y, Meng Z, Edman-Woolcott M, Hamm-Alvarez SF, Zandi E. PMID: 26807013; PMCID: PMC4720167.
      View in: PubMed   Mentions: 5  
    2. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. PMID: 25530855; PMCID: PMC4270104.
      View in: PubMed   Mentions: 24     Fields: