Andrew Mackay, PhD

Title(s)Associate Professor
SchoolUSC School of Pharmacy
Address1985 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 4118
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    Collapse Overview 
    Collapse Overview
    Our lab engineers innovative protein-polymer tools and drug carriers that respond to their environment. Cancer and ocular drug delivery are our primary focus; however, we also develop biomaterials that modulate cell signaling and trafficking. Protein-polymers are repetitive polypeptides that can be expressed in cells, fused to functional peptides, and tuned to respond to cues such as temperature, concentration, or nanoassembly. Composed from genetically-engineered biomaterials, their sequence and behavior can be precisely tailored at the genetic level. Drug delivery in the eye and cancer is often limited by access to and retention at the target site. In addition, many small molecules are dose-limited by toxicity at peripheral sites in the body. Our strategy is to repackage drugs and functional peptides into protein-polymers that control release and reduce toxicity. Successful carrier strategies are being formulated and evaluated for translation to the clinic. Using these biomaterials, our group has recently made significant breakthroughs by assembling 'microdomains' inside living cells. When decorated with functional proteins, these microdomains are helping us to precisely modulate cellular biology. To explore the potential for these new tools, we explore fundamental relationships between microdomain phase behavior and interactions with other proteins, membranes, organelles, and cells. Please explore our lab website to learn more about our work.

    Dr. MacKay received his SB in chemical engineering and biology from the Massachusetts Institute of Technology in 1999. A Howard Hughes Medical Institute Predoctoral Fellow, he completed his PhD at the University of California at San Francisco and Berkeley in the joint graduate group in Bioengineering in 2005. As a Kirschstein National Research Service Award Postdoctoral Fellow, Dr. MacKay studied at Duke University in the Department of Biomedical Engineering. In 2008 Dr. MacKay joined the faculty at the University of Southern California. Dr. MacKay is a full member of the USC Norris Comprehensive Cancer Center. He has authored over 49 peer-reviewed publications. His work is and has been supported by the US Army, NIH/NIGMS, NIH/NIBIB, NIH/NEI, StopCancer, USC Ming Hsieh Institute, and the USC Whittier Foundation. His group explores biomolecular engineering and nanomedicine. At the USC School of Pharmacy, Dr. MacKay has deep expertise teaching drug delivery, nanoscience, and pharmacokinetics.

    Collapse Research 
    Collapse Research Activities and Funding
    Protein-polymer nanomedicine for Sjogren's Syndrome
    NIH R01EY026635Mar 1, 2017 - Feb 28, 2022
    Role: Co-Principal Investigator
    Intracellular switching using genetically engineered protein microdomains
    NIH R01GM114839Apr 1, 2015 - Mar 31, 2021
    Role: Principal Investigator
    A rapid, reversible switch for controlling intracellular trafficking
    NIH R21EB012281Jul 1, 2010 - Jun 30, 2013
    Role: Principal Investigator
    pH sensitive elastin-like-peptides for tumor targeting
    NIH F32CA123889Jul 1, 2006 - Jun 30, 2008
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Steric stabilization of bioactive nanoparticles using elastin-like polypeptides. Adv Drug Deliv Rev. 2024 Mar; 206:115189. Phan A, MacKay JA. PMID: 38281625.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Noncovalent Conjugation of OVA323 to ELP Micelles Increases Immune Response. Biomacromolecules. 2024 Feb 12; 25(2):1027-1037. van Strien J, Makurat M, Zeng Y, Olsthoorn R, Schneider GF, Slütter B, MacKay JA, Jiskoot W, Kros A. PMID: 38166400; PMCID: PMC10865353.
      View in: PubMed   Mentions:    Fields:    
    3. αB-Crystallin Peptide Fused with Elastin-like Polypeptide: Intracellular Activity in Retinal Pigment Epithelial Cells Challenged with Oxidative Stress. Antioxidants (Basel). 2023 Sep 30; 12(10). Attia SA, Truong AT, Phan A, Lee SJ, Abanmai M, Markanovic M, Avila H, Luo H, Ali A, Sreekumar PG, Kannan R, MacKay JA. PMID: 37891896; PMCID: PMC10604459.
      View in: PubMed   Mentions:
    4. Biomimetic SARS-CoV-2 Spike Protein Nanoparticles. Biomacromolecules. 2023 05 08; 24(5):2030-2041. Phan A, Avila H, MacKay JA. PMID: 37001147.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model. Front Immunol. 2022; 13:1006776. van Strien J, Warmenhoven H, Logiantara A, Makurat M, Aglas L, Bethanis A, Leboux R, van Rijt L, MacKay JA, van Schijndel JW, Schneider G, Olsthoorn R, Jiskoot W, van Ree R, Kros A. PMID: 36275650; PMCID: PMC9583423.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    6. Protein and polypeptide mediated delivery to the eye. Adv Drug Deliv Rev. 2022 09; 188:114441. Attia SA, MacKay JA. PMID: 35817213; PMCID: PMC10049092.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Hydra-Elastin-like Polypeptides Increase Rapamycin Potency When Targeting Cell Surface GRP78. Biomacromolecules. 2022 08 08; 23(8):3116-3129. Avila H, Yu J, Boddu G, Phan A, Truong A, Peddi S, Guo H, Lee SJ, Alba M, Canfield E, Yamamoto V, Paton JC, Paton AW, Lee AS, MacKay JA. PMID: 35786858; PMCID: PMC10231879.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    8. Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren's syndrome. Biomaterials. 2022 04; 283:121441. Guo H, Ju Y, Choi M, Edman MC, Louie SG, Hamm-Alvarez SF, MacKay JA. PMID: 35306230; PMCID: PMC8982551.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    9. Intracellular Dynamin Elastin-like Polypeptides Assemble into Rodlike, Spherical, and Reticular Dynasomes. Biomacromolecules. 2022 01 10; 23(1):265-275. Avila H, Truong A, Tyrpak D, Park SJ, Lei S, Li Y, Okamoto C, Hamm-Alvarez S, MacKay JA. PMID: 34914359; PMCID: PMC9159747.
      View in: PubMed   Mentions: 1     Fields:    
    10. Single-Cell Quantification of the Transition Temperature of Intracellular Elastin-like Polypeptides. ACS Biomater Sci Eng. 2021 02 08; 7(2):428-440. Tyrpak DR, Li Y, Lei S, Avila H, MacKay JA. PMID: 33455201; PMCID: PMC8375696.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    11. Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren's Syndrome. Biomacromolecules. 2021 03 08; 22(3):1102-1114. Ju Y, Edman MC, Guo H, Janga SR, Peddi S, Louie SG, Junge JA, MacKay JA, Hamm-Alvarez SF. PMID: 33356170; PMCID: PMC8015671.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    12. SIAL: A simple image analysis library for wet-lab scientists. J Open Source Softw. 2020; 5(56). Tyrpak DR, Li Y, Lei S, MacKay JA. PMID: 34414350; PMCID: PMC8373214.
      View in: PubMed   Mentions: 3  
    13. Live long and active: Polypeptide-mediated assembly of antibody variable fragments. Adv Drug Deliv Rev. 2020 12; 167:1-18. Lee C, Choi M, MacKay JA. PMID: 33129938; PMCID: PMC8382037.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Adaptable antibody Nanoworms designed for non-Hodgkin lymphoma. Biomaterials. 2020 12; 262:120338. Lee C, Peddi S, Anderson C, Su H, Cui H, Epstein AL, MacKay JA. PMID: 32916604; PMCID: PMC8386582.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    15. Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium. Int J Mol Sci. 2020 Aug 26; 21(17). Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA. PMID: 32859014; PMCID: PMC7504496.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    16. Berunda Polypeptides Carrying Rapalogues Inhibit Tumor mTORC1 Better than Oral Everolimus. Biomacromolecules. 2020 08 10; 21(8):3038-3046. Peddi S, MacKay JA. PMID: 32484665; PMCID: PMC8386583.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimals
    17. Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia. Nanomedicine. 2020 10; 29:102236. Vaikari VP, Park M, Keossayan L, MacKay JA, Alachkar H. PMID: 32535112; PMCID: PMC7508895.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    18. Anti-FLT3 nanoparticles for acute myeloid leukemia: Preclinical pharmacology and pharmacokinetics. J Control Release. 2020 08 10; 324:317-329. Park M, Vaikari VP, Lam AT, Zhang Y, MacKay JA, Alachkar H. PMID: 32428520; PMCID: PMC7473778.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    19. Human Granulocyte-Macrophage Colony-Stimulating Factor Fused to Elastin-Like Polypeptides Assembles Biologically-Active Nanoparticles. Bioconjug Chem. 2020 05 20; 31(5):1551-1561. Park M, Vaikari VP, Dhandhukia JP, Alachkar H, MacKay JA. PMID: 32319752; PMCID: PMC7489497.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. A Multivalent ICAM-1 Binding Nanoparticle which Inhibits ICAM-1 and LFA-1 Interaction Represents a New Tool for the Investigation of Autoimmune-Mediated Dry Eye. Int J Mol Sci. 2020 Apr 15; 21(8). Hsueh PY, Ju Y, Vega A, Edman MC, MacKay JA, Hamm-Alvarez SF. PMID: 32326657; PMCID: PMC7216292.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    21. Evaluation of extracellular matrix mimetic laminin bioactive peptide and elastin-like polypeptide. FASEB J. 2020 05; 34(5):6729-6740. Truong AT, Hamada K, Yamada Y, Guo H, Kikkawa Y, Okamoto CT, MacKay JA, Nomizu M. PMID: 32248607.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    22. Nanotoxicology of an Elastin-like Polypeptide Rapamycin Formulation for Breast Cancer. Biomacromolecules. 2020 03 09; 21(3):1091-1102. Peddi S, Roberts SK, MacKay JA. PMID: 31927993; PMCID: PMC7219203.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    23. Advanced drug delivery 2020 - Parts 1,2 and 3. Adv Drug Deliv Rev. 2020; 156:1-2. Ghandehari H, Chan HK, Harashima H, MacKay JA, Minko T, Schenke-Layland K, Shen Y, Vicent MJ. PMID: 33308449.
      View in: PubMed   Mentions: 1     Fields:    
    24. Caveolin elastin-like polypeptide fusions mediate temperature-dependent assembly of caveolar microdomains. ACS Biomater Sci Eng. 2020 01 13; 6(1):198-204. Tyrpak DR, Wang Y, Avila H, Guo H, Fu R, Truong AT, Park M, Okamoto CT, Hamm-Alvarez SF, MacKay JA. PMID: 32542186; PMCID: PMC7295141.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    25. The humanin peptide mediates ELP nanoassembly and protects human retinal pigment epithelial cells from oxidative stress. Nanomedicine. 2020 02; 24:102111. Li Z, Sreekumar PG, Peddi S, Hinton DR, Kannan R, MacKay JA. PMID: 31655204; PMCID: PMC7263384.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    26. Molecular Targeting of Immunosuppressants Using a Bifunctional Elastin-Like Polypeptide. Bioconjug Chem. 2019 09 18; 30(9):2358-2372. Ju Y, Guo H, Yarber F, Edman MC, Peddi S, Janga SR, MacKay JA, Hamm-Alvarez SF. PMID: 31408605; PMCID: PMC6980866.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Generation of a Monoclonal Antibody to Detect Elastin-like Polypeptides. Biomacromolecules. 2019 08 12; 20(8):2942-2952. Kouhi A, Yao Z, Zheng L, Li Z, Hu P, Epstein AL, MacKay JA. PMID: 31276401; PMCID: PMC7219198.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsPHPublic Health
    28. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome. Sci Rep. 2019 07 02; 9(1):9559. Klinngam W, Janga SR, Lee C, Ju Y, Yarber F, Shah M, Guo H, Wang D, MacKay JA, Edman MC, Hamm-Alvarez SF. PMID: 31267034; PMCID: PMC6606642.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    29. Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease. Mol Pharm. 2019 07 01; 16(7):3024-3039. Lee C, Guo H, Klinngam W, Janga SR, Yarber F, Peddi S, Edman MC, Tiwari N, Liu S, Louie SG, Hamm-Alvarez SF, MacKay JA. PMID: 31095909; PMCID: PMC6957305.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    30. Thermally-Responsive Loading and Release of Elastin-Like Polypeptides from Contact Lenses. Pharmaceutics. 2019 May 07; 11(5). Wang W, Lee C, Pastuszka M, Laurie GW, MacKay JA. PMID: 31067782; PMCID: PMC6572635.
      View in: PubMed   Mentions: 6  
    31. A novel elastin-like polypeptide drug carrier for cyclosporine A improves tear flow in a mouse model of Sjögren's syndrome. J Control Release. 2018 12 28; 292:183-195. Guo H, Lee C, Shah M, Janga SR, Edman MC, Klinngam W, Hamm-Alvarez SF, MacKay JA. PMID: 30359668; PMCID: PMC6294338.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    32. Intracellular Delivery of Rapamycin From FKBP Elastin-Like Polypeptides Is Consistent With Macropinocytosis. Front Pharmacol. 2018; 9:1184. Peddi S, Pan X, MacKay JA. PMID: 30386244; PMCID: PMC6199897.
      View in: PubMed   Mentions: 8  
    33. Tunable assembly of protein-microdomains in living vertebrate embryos. Adv Biosyst. 2018 10; 2(10). Li Z, Tyrpak DR, Lien CL, MacKay JA. PMID: 31840042; PMCID: PMC6910210.
      View in: PubMed   Mentions: 4     Fields:    
    34. NOD and NOR mice exhibit comparable development of lacrimal gland secretory dysfunction but NOD mice have more severe autoimmune dacryoadenitis. Exp Eye Res. 2018 11; 176:243-251. Ju Y, Janga SR, Klinngam W, MacKay JA, Hawley D, Zoukhri D, Edman MC, Hamm-Alvarez SF. PMID: 30201519; PMCID: PMC6215720.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    35. A new temperature-dependent strategy to modulate the epidermal growth factor receptor. Biomaterials. 2018 11; 183:319-330. Li Z, Tyrpak DR, Park M, Okamoto CT, MacKay JA. PMID: 30196151; PMCID: PMC6338443.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    36. Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration. J Control Release. 2018 08 10; 283:94-104. Sreekumar PG, Li Z, Wang W, Spee C, Hinton DR, Kannan R, MacKay JA. PMID: 29778783; PMCID: PMC6368441.
      View in: PubMed   Mentions: 19     Fields:    Translation:Animals
    37. Bifunctional Elastin-like Polypeptide Nanoparticles Bind Rapamycin and Integrins and Suppress Tumor Growth in Vivo. Bioconjug Chem. 2017 11 15; 28(11):2715-2728. Dhandhukia JP, Shi P, Peddi S, Li Z, Aluri S, Ju Y, Brill D, Wang W, Janib SM, Lin YA, Liu S, Cui H, MacKay JA. PMID: 28937754; PMCID: PMC5779105.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    38. Berunda Polypeptides: Multi-Headed Fusion Proteins Promote Subcutaneous Administration of Rapamycin to Breast Cancer In Vivo. Theranostics. 2017; 7(16):3856-3872. Dhandhukia JP, Li Z, Peddi S, Kakan S, Mehta A, Tyrpak D, Despanie J, MacKay JA. PMID: 29109782; PMCID: PMC5667409.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    39. Elastin-like polypeptide switches: A design strategy to detect multimeric proteins. Protein Sci. 2017 Sep; 26(9):1785-1795. Dhandhukia JP, Brill DA, Kouhi A, Pastuszka MK, MacKay JA. PMID: 28639381; PMCID: PMC5563140.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    40. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay JA, Hamm-Alvarez SF. PMID: 28122086; PMCID: PMC5270623.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    41. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 10 28; 240:93-108. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay JA. PMID: 26578439; PMCID: PMC5767577.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    42. Image-driven pharmacokinetics: nanomedicine concentration across space and time. Nanomedicine (Lond). 2015; 10(18):2861-79. Brill DA, MacKay JA. PMID: 26370694.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    43. Engineering structure and function using thermoresponsive biopolymers. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan-Feb; 8(1):123-38. Pastuszka MK, MacKay JA. PMID: 26112277; PMCID: PMC4732732.
      View in: PubMed   Mentions: 4     Fields:    
    44. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay JA. PMID: 25523518; PMCID: PMC4456098.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    45. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B. 2014 Dec 14; 2(46):8131-8141. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA. PMID: 25530855; PMCID: PMC4270104.
      View in: PubMed   Mentions: 24     Fields:    
    46. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay JA. PMID: 25481446; PMCID: PMC4456095.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    47. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. PMID: 25419208; PMCID: PMC4235962.
      View in: PubMed   Mentions: 13  
    48. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. PMID: 25016969; PMCID: PMC4327866.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    49. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 2014 Jul 14; 15(7):2347-58. Janib SM, Gustafson JA, Minea RO, Swenson SD, Liu S, Pastuszka MK, Lock LL, Cui H, Markland FS, Conti PS, Li Z, MacKay JA. PMID: 24871936; PMCID: PMC4098058.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    50. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014 Oct 10; 191:4-14. Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay JA. PMID: 24780268; PMCID: PMC4222838.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    51. Genetically engineered nanocarriers for drug delivery. Int J Nanomedicine. 2014; 9:1617-26. Shi P, Gustafson JA, MacKay JA. PMID: 24741309; PMCID: PMC3970941.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    52. A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody. ACS Nano. 2014 Mar 25; 8(3):2064-76. Aluri SR, Shi P, Gustafson JA, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, MacKay JA. PMID: 24484356; PMCID: PMC4004287.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    53. A quantitative recipe for engineering protein polymer nanoparticles. Polym Chem. 2014 Jan; 5(5):1614-1625. Janib SM, Pastuszka M, Aluri S, Folchman-Wagner Z, Hsueh PY, Shi P, Cui H, Mackay JA. PMID: 24511327; PMCID: PMC3916011.
      View in: PubMed   Mentions: 41  
    54. Triggered sorting and co-assembly of genetically engineered protein microdomains in the cytoplasm. Adv Mater. 2014 Jan 22; 26(3):449-54. Shi P, Lin YA, Pastuszka M, Cui H, Mackay JA. PMID: 24136711; PMCID: PMC3947098.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    55. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. PMID: 23892265; PMCID: PMC3796004.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    56. Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. J Control Release. 2013 Nov 10; 171(3):330-8. Shi P, Aluri S, Lin YA, Shah M, Edman M, Dhandhukia J, Cui H, MacKay JA. PMID: 23714121; PMCID: PMC3795821.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    57. Switchable elastin-like polypeptides that respond to chemical inducers of dimerization. Biomacromolecules. 2013 Apr 08; 14(4):976-85. Dhandhukia J, Weitzhandler I, Wang W, MacKay JA. PMID: 23406497; PMCID: PMC3721738.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    58. Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integr Biol (Camb). 2013 Jan; 5(1):183-94. Janib SM, Liu S, Park R, Pastuszka MK, Shi P, Moses AS, Orosco MM, Lin YA, Cui H, Conti PS, Li Z, MacKay JA. PMID: 23093022; PMCID: PMC3762326.
      View in: PubMed   Mentions: 22     Fields:    Translation:Cells
    59. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. PMID: 23088632; PMCID: PMC3500625.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    60. Elastin-like peptide amphiphiles form nanofibers with tunable length. Biomacromolecules. 2012 Sep 10; 13(9):2645-54. Aluri S, Pastuszka MK, Moses AS, MacKay JA. PMID: 22849577; PMCID: PMC3461336.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    61. Biodegradation of elastin-like polypeptide nanoparticles. Protein Sci. 2012 Jun; 21(6):743-50. Shah M, Hsueh PY, Sun G, Chang HY, Janib SM, MacKay JA. PMID: 22434766; PMCID: PMC3403411.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    62. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, MacKay JA. PMID: 21699930; PMCID: PMC3196066.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    63. NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS. Technol Innov. 2011 Jan 01; 13(1):5-25. Chen M, McDaniel JR, Mackay JA, Chilkoti A. PMID: 24077873; PMCID: PMC3784687.
      View in: PubMed   Mentions: 1  
    64. Proceedings of the National Academy of Inventors. Nanoscale Self-Assembly for Delivery of Therapeutics and Imaging Agents. 2011; 1(13):5-25. Chen M, McDaniel JR, MacKay JA, Chilkoti, A.
    65. Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides. Biomacromolecules. 2010 Nov 08; 11(11):2873-9. Mackay JA, Callahan DJ, Fitzgerald KN, Chilkoti A. PMID: 20925333; PMCID: PMC3032028.
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    66. Theranostic agents that co-deliver therapeutic and imaging agents? Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1003-4. MacKay JA, Li Z. PMID: 20937334.
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    67. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1052-1063. Janib SM, Moses AS, MacKay JA. PMID: 20709124; PMCID: PMC3769170.
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    68. Biomolecular engineering of intracellular switches in eukaryotes. J Drug Deliv Sci Technol. 2010 May; 20(3):163-169. Pastuszka MK, Mackay JA. PMID: 21209849; PMCID: PMC3013508.
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    69. Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes. Biomacromolecules. 2010 Apr 12; 11(4):944-52. McDaniel JR, Mackay JA, Quiroz FG, Chilkoti A. PMID: 20184309; PMCID: PMC2862688.
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    70. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J Control Release. 2010 May 21; 144(1):2-9. Liu W, MacKay JA, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR, Chilkoti A. PMID: 20117157; PMCID: PMC2862899.
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    71. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection. Nat Mater. 2009 Dec; 8(12):993-9. MacKay JA, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A. PMID: 19898461; PMCID: PMC2862348.
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    72. In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics. Proc Natl Acad Sci U S A. 2009 Sep 08; 106(36):15231-6. Gao W, Liu W, Mackay JA, Zalutsky MR, Toone EJ, Chilkoti A. PMID: 19706892; PMCID: PMC2731796.
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    73. Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev. 2009 Sep 30; 61(11):940-52. Aluri S, Janib SM, Mackay JA. PMID: 19628014; PMCID: PMC2757494.
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    74. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules. 2009 Jan 12; 10(1):19-24. Wu Y, MacKay JA, McDaniel JR, Chilkoti A, Clark RL. PMID: 19072041; PMCID: PMC2820340.
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    75. Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. Int J Hyperthermia. 2008 Sep; 24(6):483-95. Mackay JA, Chilkoti A. PMID: 18608590; PMCID: PMC2820342.
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    76. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther. 2008 May; 16(5):893-900. MacKay JA, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. PMID: 18388927.
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    77. Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. Biomacromolecules. 2007 May; 8(5):1417-24. Lim DW, Trabbic-Carlson K, Mackay JA, Chilkoti A. PMID: 17407348; PMCID: PMC2562536.
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    78. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Curr Opin Chem Biol. 2006 Dec; 10(6):652-7. Chilkoti A, Christensen T, MacKay JA. PMID: 17055770; PMCID: PMC3732176.
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    79. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11; 128(1):60-1. Huang Z, Guo X, Li W, MacKay JA, Szoka FC. PMID: 16390121; PMCID: PMC3280609.
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    80. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec; 23(12):1517-26. Lee CC, MacKay JA, Fréchet JM, Szoka FC. PMID: 16333296.
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    81. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar; 11(3):409-17. Huang Z, Li W, MacKay JA, Szoka FC. PMID: 15727937.
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    82. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. PMID: 15707893.
      View in: PubMed   Mentions: 188     Fields:    Translation:HumansAnimalsCells
    83. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28; 1035(2):139-53. MacKay JA, Deen DF, Szoka FC. PMID: 15722054.
      View in: PubMed   Mentions: 65     Fields:    Translation:Animals
    84. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan; 7(1):67-79. Li W, Huang Z, MacKay JA, Grube S, Szoka FC. PMID: 15515149.
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    85. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar; 84(3):1784-95. Guo X, MacKay JA, Szoka FC. PMID: 12609880; PMCID: PMC1302747.
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    86. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr; 14(2):420-9. Choi JS, MacKay JA, Szoka FC. PMID: 12643753.
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    87. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. J Dispers Sci Technol. 2003; 24(3):465-473. Mackay JA, Szoka FC. PMID: 20808712; PMCID: PMC2929673.
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    88. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 2001 May; 55(2):229-35. Martin I, Shastri VP, Padera RF, Yang J, Mackay AJ, Langer R, Vunjak-Novakovic G, Freed LE. PMID: 11255174.
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