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Laurie D. De Leve, MD, PhD

TitleProfessor of Medicine
InstitutionUniversity of Southern California
DepartmentMedicine
AddressHMR 603
Health Sciences Campus
Los Angeles CA 90089-9091
Phone+1 323 442 3248
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    Other Positions
    TitleSenior Associate Chair For Scientific Affairs, Department of Medicine


    Collapse Biography 
    Collapse Awards and Honors
    Alpha Omega Alpha2005Teaching Award
    Western Society for Clinical Investigation2008Outstanding Investigator Award
    USC2015Mellon Mentoring Award for Faculty Mentoring Faculty

    Collapse Overview 
    Collapse Overview
    Dr. DeLeve's clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

    Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.


    Collapse Research 
    Collapse Research Activities and Funding
    Liver sinusoidal endothelial cells and fibrosis.
    NIH/NIDDK R01DK100580Aug 1, 2014 - Jul 31, 2018
    Role: Principal Investigator
    Determinants of Sinusoidal Endothelial Cell Phenotype.
    NIH/NIDDK R01DK066423Aug 15, 2003 - Jun 30, 2012
    Role: Principal Investigator
    Liver Sinusoidal Endothelial Cell Progenitor Cells.
    NIH/NIDDK R01DK046357Jan 1, 1994 - Mar 31, 2018
    Role: Principal Investigator
    MECHANISMS OF TOXICITY IN SINUSOIDAL ENDOTHELIAL CELLS
    NIH/NIDDK R29DK046357Jan 1, 1994 - Dec 31, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Wang X, Maretti-Mira AC, Wang L, DeLeve LD. Liver-selective mmp-9 inhibition in the rat eliminates ischemia-reperfusion injury and accelerates liver regeneration. Hepatology. 2018 Jul 17. PMID: 30019419.
      View in: PubMed
    2. DeLeve LD, Maretti-Mira AC. Liver Sinusoidal Endothelial Cell: An Update. Semin Liver Dis. 2017 Nov; 37(4):377-387. PMID: 29272898.
      View in: PubMed
    3. DeLeve LD, Wang X, Wang L. VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 May 01; 310(9):G739-46. PMID: 26939868; PMCID: PMC4867332 [Available on 05/01/17].
    4. DeLeve LD. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6. PMID: 25131509; PMCID: PMC4333127.
    5. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. PMID: 25016969; PMCID: PMC4327866.
    6. DeLeve LD. Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest. 2013 May; 123(5):1861-6. PMID: 23635783; PMCID: PMC3635729.
    7. Tallman MS, McDonald GB, DeLeve LD, Baer MR, Cook MN, Graepel GJ, Kollmer C. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Int J Hematol. 2013 Apr; 97(4):456-64. PMID: 23460018.
      View in: PubMed
    8. Wang L, Wang X, Wang L, Chiu JD, van de Ven G, Gaarde WA, Deleve L. Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology. 2012 Dec; 143(6):1555-1563.e2. PMID: 22902870.
      View in: PubMed
    9. Wang L, Wang X, Xie G, Wang L, Hill CK, DeLeve LD. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest. 2012 Apr; 122(4):1567-73. PMID: 22406533; PMCID: PMC3314456.
    10. Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve L. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927.e6. PMID: 22178212; PMCID: PMC3618963.
    11. Warren A, Cogger VC, Fraser R, Deleve L, McCuskey RS, Le Couteur DG. The effects of old age on hepatic stellate cells. Curr Gerontol Geriatr Res. 2011; 2011:439835. PMID: 21687587; PMCID: PMC3114409.
    12. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
    13. Xie G, Wang L, Wang X, Wang L, DeLeve LD. Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. PMID: 20813915; PMCID: PMC2993174.
    14. Cogger VC, McNerney GP, Nyunt T, DeLeve LD, McCourt P, Smedsrød B, Le Couteur DG, Huser TR. Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol. 2010 Sep; 171(3):382-8. PMID: 20570732; PMCID: PMC3043550.
    15. Harb R, Xie G, Lutzko C, Guo Y, Wang X, Hill CK, Kanel GC, DeLeve LD. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. PMID: 19447108; PMCID: PMC2747805.
    16. DeLeve LD, Valla DC, Garcia-Tsao G. Vascular disorders of the liver. Hepatology. 2009 May; 49(5):1729-64. PMID: 19399912.
      View in: PubMed
    17. DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. PMID: 18772330; PMCID: PMC2543068.
    18. Deleve L, Wang X, Guo Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 2008 Sep; 48(3):920-30. PMID: 18613151; PMCID: PMC2695448.
    19. Deleve L. Sinusoidal obstruction syndrome. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. PMID: 21904484; PMCID: PMC3088834.
    20. DeLeve LD. Hepatic microvasculature in liver injury. Semin Liver Dis. 2007 Nov; 27(4):390-400. PMID: 17979075.
      View in: PubMed
    21. DeLeve LD, Wang X, McCuskey MK, McCuskey RS. Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. PMID: 16782698.
      View in: PubMed
    22. McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, Ito Y, DeLeve LD. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 2005 Mar; 42(3):371-7. PMID: 15710220.
      View in: PubMed
    23. DeLeve LD, Wang X, Hu L, McCuskey MK, McCuskey RS. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. PMID: 15191879.
      View in: PubMed
    24. Adams PC, Arthur MJ, Boyer TD, DeLeve LD, Di Bisceglie AM, Hall M, Levin TR, Provenzale D, Seeff L. Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004 May; 39(5):1204-12. PMID: 15122748.
      View in: PubMed
    25. DeLeve LD, Wang X, Kanel GC, Ito Y, Bethea NW, McCuskey MK, Tokes ZA, Tsai J, McCuskey RS. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. PMID: 14512877.
      View in: PubMed
    26. Deleve L, Wang X, Tsai J, Kanel G, Strasberg S, Tokes ZA. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. PMID: 12949732.
      View in: PubMed
    27. Kumar S, DeLeve LD, Kamath PS, Tefferi A. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc. 2003 May; 78(5):589-98. PMID: 12744547.
      View in: PubMed
    28. DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X, McCuskey RS. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. PMID: 12584111.
      View in: PubMed
    29. DeLeve LD. Vascular liver diseases. Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. PMID: 12530950.
      View in: PubMed
    30. Poreddy V, DeLeve LD. Hepatic circulatory diseases associated with chronic myeloid disorders. Clin Liver Dis. 2002 Nov; 6(4):909-31. PMID: 12516199.
      View in: PubMed
    31. DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002 Feb; 22(1):27-42. PMID: 11928077.
      View in: PubMed
    32. DeLeve LD. Hepatic venoocclusive disease: a major complication of hematopoietic stem cell transplantation in cancer patients. Tumori. 2001 Mar-Apr; 87(2):S27-9. PMID: 11401220.
      View in: PubMed
    33. DeLeve LD, Wang X. Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes. Pharmacology. 2000 Apr; 60(3):143-54. PMID: 10754451.
      View in: PubMed
    34. Wang X, Kanel GC, DeLeve LD. Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34. PMID: 10655267.
      View in: PubMed
    35. DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel GC. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91. PMID: 10347121.
      View in: PubMed
    36. DeLeve LD. Glutathione defense in non-parenchymal cells. Semin Liver Dis. 1998; 18(4):403-13. PMID: 9875557.
      View in: PubMed
    37. DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. PMID: 9214695.
      View in: PubMed
    38. DeLeve LD. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology. 1996 Oct; 24(4):830-7. PMID: 8855185.
      View in: PubMed
    39. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. PMID: 8617441.
      View in: PubMed
    40. DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. PMID: 8749899.
      View in: PubMed
    41. Runnegar MT, Maddatu T, Deleve L, Berndt N, Govindarajan S. Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 1995 Apr; 273(1):545-53. PMID: 7714810.
      View in: PubMed
    42. Deleve L. Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther. 1994 Mar; 268(3):1261-70. PMID: 8138939.
      View in: PubMed
    43. DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. PMID: 1820580.
      View in: PubMed
    44. DeLeve LD, Kaplowitz N. Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. PMID: 2281333.
      View in: PubMed
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