Laurie D. De Leve, MD, PhD

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
AddressHMR 603
Health Sciences Campus
Los Angeles CA 90089-9091
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    Other Positions
    Title(s)Vice Chair for Scientific Affairs, DOM


    Collapse Biography 
    Collapse Awards and Honors
    Alpha Omega Alpha2005Teaching Award
    Western Society for Clinical Investigation2008Outstanding Investigator Award
    USC2015Mellon Mentoring Award for Faculty Mentoring Faculty

    Collapse Overview 
    Collapse Overview
    Dr. DeLeve's clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

    Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.

    Collapse Research 
    Collapse Research Activities and Funding
    Liver Sinusoidal Endothelial Cell Progenitor Cells (sprocs) and Chronic Liver Disease
    NIH R01DK100580Aug 1, 2014 - Dec 31, 2023
    Role: Principal Investigator
    Determinants of Sinusoidal Endothelial Cell Phenotype.
    NIH R01DK066423Aug 15, 2003 - Jun 30, 2012
    Role: Principal Investigator
    Liver Sinusoidal Endothelial Cell Progenitor Cells.
    NIH R01DK046357Jan 1, 1994 - Mar 31, 2019
    Role: Principal Investigator
    MECHANISMS OF TOXICITY IN SINUSOIDAL ENDOTHELIAL CELLS
    NIH R29DK046357Jan 1, 1994 - Dec 31, 1998
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Susceptibility of Rat Steatotic Liver to Ischemia-Reperfusion Is Treatable With Liver-Selective Matrix Metalloproteinase Inhibition. Hepatology. 2020 11; 72(5):1771-1785. Wang X, Walkey CJ, Maretti-Mira AC, Wang L, Johnson DL, DeLeve LD. PMID: 32060938; PMCID: PMC7523533.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    2. Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program. Clin Trials. 2019 06; 16(3):253-262. Shavadia JS, Sharma A, Gu X, Neaton J, DeLeve L, Holmes D, Home P, Eckel RH, Watkins PB, Granger CB. PMID: 30880443.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    3. Sinusoids as Drivers of Liver Development: More Than Simple Chemistry. Hepatology. 2019 08; 70(2):737-739. Maretti-Mira AC, DeLeve LD. PMID: 30681732.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    4. Incomplete Differentiation of Engrafted Bone Marrow Endothelial Progenitor Cells Initiates Hepatic Fibrosis in the Rat. Hepatology. 2019 03; 69(3):1259-1272. Maretti-Mira AC, Wang X, Wang L, DeLeve LD. PMID: 30141211; PMCID: PMC6387651.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    5. Liver Complications Following Treatment of Hematologic Malignancy With Anti-CD22-Calicheamicin (Inotuzumab Ozogamicin). Hepatology. 2019 02; 69(2):831-844. McDonald GB, Freston JW, Boyer JL, DeLeve LD. PMID: 30120894; PMCID: PMC6351187.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCTClinical Trials
    6. Liver-Selective MMP-9 Inhibition in the Rat Eliminates Ischemia-Reperfusion Injury and Accelerates Liver Regeneration. Hepatology. 2019 01; 69(1):314-328. Wang X, Maretti-Mira AC, Wang L, DeLeve LD. PMID: 30019419; PMCID: PMC6325019.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    7. Liver Sinusoidal Endothelial Cell: An Update. Semin Liver Dis. 2017 11; 37(4):377-387. DeLeve LD, Maretti-Mira AC. PMID: 29272898; PMCID: PMC6005648.
      View in: PubMed   Mentions: 72     Fields:    Translation:HumansAnimalsCells
    8. VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 05 01; 310(9):G739-46. DeLeve LD, Wang X, Wang L. PMID: 26939868; PMCID: PMC4867332.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    9. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6. DeLeve LD. PMID: 25131509; PMCID: PMC4333127.
      View in: PubMed   Mentions: 190     Fields:    Translation:HumansCells
    10. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. PMID: 25016969; PMCID: PMC4327866.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest. 2013 May; 123(5):1861-6. DeLeve LD. PMID: 23635783; PMCID: PMC3635729.
      View in: PubMed   Mentions: 102     Fields:    Translation:HumansAnimalsCells
    12. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Int J Hematol. 2013 Apr; 97(4):456-64. Tallman MS, McDonald GB, DeLeve LD, Baer MR, Cook MN, Graepel GJ, Kollmer C. PMID: 23460018.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    13. Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology. 2012 Dec; 143(6):1555-1563.e2. Wang L, Wang X, Wang L, Chiu JD, van de Ven G, Gaarde WA, Deleve LD. PMID: 22902870; PMCID: PMC3505224.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    14. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest. 2012 Apr; 122(4):1567-73. Wang L, Wang X, Xie G, Wang L, Hill CK, DeLeve LD. PMID: 22406533; PMCID: PMC3314456.
      View in: PubMed   Mentions: 86     Fields:    Translation:AnimalsCells
    15. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927.e6. Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve LD. PMID: 22178212; PMCID: PMC3618963.
      View in: PubMed   Mentions: 169     Fields:    Translation:AnimalsCells
    16. The effects of old age on hepatic stellate cells. Curr Gerontol Geriatr Res. 2011; 2011:439835. Warren A, Cogger VC, Fraser R, Deleve LD, McCuskey RS, Le Couteur DG. PMID: 21687587; PMCID: PMC3114409.
      View in: PubMed   Mentions: 21  
    17. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. PMID: 21645207; PMCID: PMC4388239.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    18. Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. Xie G, Wang L, Wang X, Wang L, DeLeve LD. PMID: 20813915; PMCID: PMC2993174.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    19. Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol. 2010 Sep; 171(3):382-8. Cogger VC, McNerney GP, Nyunt T, DeLeve LD, McCourt P, Smedsrød B, Le Couteur DG, Huser TR. PMID: 20570732; PMCID: PMC3043550.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    20. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. Harb R, Xie G, Lutzko C, Guo Y, Wang X, Hill CK, Kanel GC, DeLeve LD. PMID: 19447108; PMCID: PMC2747805.
      View in: PubMed   Mentions: 49     Fields:    Translation:AnimalsCells
    21. Vascular disorders of the liver. Hepatology. 2009 May; 49(5):1729-64. DeLeve LD, Valla DC, Garcia-Tsao G, American Association for the Study Liver Diseases. PMID: 19399912; PMCID: PMC6697263.
      View in: PubMed   Mentions: 261     Fields:    Translation:Humans
    22. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. PMID: 18772330; PMCID: PMC2543068.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    23. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 2008 Sep; 48(3):920-30. Deleve LD, Wang X, Guo Y. PMID: 18613151; PMCID: PMC2695448.
      View in: PubMed   Mentions: 159     Fields:    Translation:AnimalsCells
    24. Sinusoidal obstruction syndrome. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. Deleve LD. PMID: 21904484; PMCID: PMC3088834.
      View in: PubMed   Mentions: 3  
    25. Hepatic microvasculature in liver injury. Semin Liver Dis. 2007 Nov; 27(4):390-400. DeLeve LD. PMID: 17979075.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimals
    26. Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. DeLeve LD, Wang X, McCuskey MK, McCuskey RS. PMID: 16782698.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    27. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 2005 Mar; 42(3):371-7. McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, Ito Y, DeLeve LD. PMID: 15710220.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    28. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. DeLeve LD, Wang X, Hu L, McCuskey MK, McCuskey RS. PMID: 15191879.
      View in: PubMed   Mentions: 123     Fields:    Translation:AnimalsCells
    29. Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004 May; 39(5):1204-12. Adams PC, Arthur MJ, Boyer TD, DeLeve LD, Di Bisceglie AM, Hall M, Levin TR, Provenzale D, Seeff L. PMID: 15122748.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansPHPublic Health
    30. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. DeLeve LD, Wang X, Kanel GC, Ito Y, Bethea NW, McCuskey MK, Tokes ZA, Tsai J, McCuskey RS. PMID: 14512877.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    31. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. Deleve LD, Wang X, Tsai J, Kanel G, Strasberg S, Tokes ZA. PMID: 12949732.
      View in: PubMed   Mentions: 52     Fields:    Translation:Animals
    32. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc. 2003 May; 78(5):589-98. Kumar S, DeLeve LD, Kamath PS, Tefferi A. PMID: 12744547.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    33. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X, McCuskey RS. PMID: 12584111.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    34. Vascular liver diseases. Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. DeLeve LD. PMID: 12530950.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    35. Hepatic circulatory diseases associated with chronic myeloid disorders. Clin Liver Dis. 2002 Nov; 6(4):909-31. Poreddy V, DeLeve LD. PMID: 12516199.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002 Feb; 22(1):27-42. DeLeve LD, Shulman HM, McDonald GB. PMID: 11928077.
      View in: PubMed   Mentions: 158     Fields:    Translation:HumansAnimals
    37. Hepatic venoocclusive disease: a major complication of hematopoietic stem cell transplantation in cancer patients. Tumori. 2001 Mar-Apr; 87(2):S27-9. DeLeve LD. PMID: 11401220.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes. Pharmacology. 2000 Apr; 60(3):143-54. DeLeve LD, Wang X. PMID: 10754451.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    39. Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34. Wang X, Kanel GC, DeLeve LD. PMID: 10655267.
      View in: PubMed   Mentions: 31     Fields:    Translation:Animals
    40. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91. DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel GC. PMID: 10347121.
      View in: PubMed   Mentions: 81     Fields:    Translation:Animals
    41. Glutathione defense in non-parenchymal cells. Semin Liver Dis. 1998; 18(4):403-13. DeLeve LD. PMID: 9875557.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    42. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. PMID: 9214695.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    43. Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethane-induced genotoxicity in human fibroblasts. Mutat Res. 1997 Mar 17; 389(2-3):291-7. DeLeve LD. PMID: 9093395.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    44. Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts. Mutat Res. 1996 Nov 04; 371(1-2):105-8. DeLeve LD. PMID: 8950355.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    45. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology. 1996 Oct; 24(4):830-7. DeLeve LD. PMID: 8855185.
      View in: PubMed   Mentions: 43     Fields:    Translation:Animals
    46. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. PMID: 8617441.
      View in: PubMed   Mentions: 45     Fields:    Translation:AnimalsCells
    47. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. DeLeve LD, Kaplowitz N. PMID: 8749899.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    48. Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 1995 Apr; 273(1):545-53. Runnegar MT, Maddatu T, Deleve LD, Berndt N, Govindarajan S. PMID: 7714810.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    49. Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther. 1994 Mar; 268(3):1261-70. Deleve LD. PMID: 8138939.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    50. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. DeLeve LD, Kaplowitz N. PMID: 1820580.
      View in: PubMed   Mentions: 82     Fields:    Translation:HumansAnimalsCells
    51. Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. DeLeve LD, Kaplowitz N. PMID: 2281333.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    52. Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity. Clin Pharmacol Ther. 1989 Sep; 46(3):279-90. Reeves RA, Boer WH, DeLeve L, Leenen FH. PMID: 2550167.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCTClinical Trials
    53. Plasma concentration-response relationships of two formulations of propranolol. J Clin Pharmacol. 1985 Apr; 25(3):182-6. DeLeve LD, Endrenyi L, Leenen FH. PMID: 3998198.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man. Clin Pharmacol Ther. 1984 Apr; 35(4):461-6. Reeves RA, Boer WH, DeLeve L, Leenen FH. PMID: 6705443.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    55. Nonselective beta-receptor stimulation and blockade and left ventricular function. Clin Pharmacol Ther. 1983 Nov; 34(5):570-5. Leenen FH, Smith DL, DeLeve L. PMID: 6138177.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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